metaM tststerones c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: testosterone sulfate
constant: false
is: HMDB02833
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
initial concentration: 1.0
boundary condition: false

metaM ipdp c
is: HMDB01347
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: Isopentenyl diphosphate
has only substance units: false
initial concentration: 1.0
is: C00129
is: SBO:0000247
constant: false
is: CHEBI:128769
initial amount: NaN
type: Species

metaR HAS1
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reactant: MODEL1310110035#
type: Reaction
name: hyaluronan synthase
product: MODEL1310110035#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6ce2dcb4_ec91_41d8_a5c9_7a3c0a5c46c9
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q86VV3
is: SBO:0000252
is encoded by: hsa:953
name: ENTPD1

metaM tststerone c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species
name: testosterone
is: HMDB00234
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17347

metaM ddsmsterol r
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
has only substance units: false
initial amount: NaN
is: CHEBI:27910
type: Species
is: HMDB03896
name: 7-dehydrodesmosterol
initial concentration: 1.0

metaM HC02214 e
name: prostaglandin-f1alpha
initial concentration: 1.0
has only substance units: false
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR S6TASE11ly
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR B3GNT31g
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
product: MODEL1310110035#
is: SBO:0000176
fast: false
is described by: ECO:0000269

metaR RTOTAL2FATPc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR RE2626C
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
name: RE2626
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
fast: false

metaR r0463
reactant: MODEL1310110035#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9e881b29_6bde_4c03_95ca_595fdca5b8dd
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57171
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DOLPP1
type: Species
is: Q86YN1
constant: false

metaM ksi pre7 g
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 7
boundary condition: false
is: C00130
is: CHEBI:58053
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C115H187N8O85SX CHARGE: -2
initial amount: NaN
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110035#_ed89ab64_4eff_48c7_8728_a39269673029
initial concentration: NaN
is: O60476
is encoded by: hsa:10905
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: MAN1A2

metaR r0093
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
modifier: MODEL1310110035#
reversible: false
is: SBO:0000176

metaR PRO Dtde
name: D-proline transport, extracellular
is described by: ECO:0000134
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
fast: false
reversible: true

metaR FUT910g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
reactant: MODEL1310110035#
type: Reaction
name: Alpha-(1,3)-fucosyltransferase
is described by: ECO:0000269
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is: SBO:0000176

metaR URAt
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110035#
fast: false
name: uracil transport via facilated diffusion
reactant: MODEL1310110035#

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM so4 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: sulfate
is: HMDB01448
has only substance units: false
type: Species
is: CHEBI:16189
constant: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR H2Otm
reversible: true
fast: false
product: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
name: H2O transport, mitochondrial
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_88924e28_b951_459a_824a_1895c6ee9f9c
type: Species
is: P61457
constant: false
is: SBO:0000252
name: PCBD1
boundary condition: true
has only substance units: false
is encoded by: hsa:5092
initial concentration: NaN
initial amount: NaN

metaR r0618
is described by: ECO:0000000
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
fast: false
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_0d19d6de_0262_4369_8f1f_337df0ab9789
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: Q3SYC2
has only substance units: false
name: MOGAT2
is encoded by: hsa:80168
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_81fd12d5_8b71_4c03_bd07_e5e6d8f66ae0
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E9PHN8
is encoded by: hsa:9843
type: Species
name: HEPH

metaR S6TASE15ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110035#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110035#

metaM tststerones e
boundary condition: false
type: Species
constant: false
name: testosterone sulfate
has only substance units: false
is: HMDB02833
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_7852787c_c80a_407b_9ba0_bd43fe79b68a
is encoded by: hsa:2235
type: Species
is: SBO:0000252
is: P22830
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: FECH

http://identifiers.org/biomodels.db/MODEL1310110035#_1b8e050b_48f3_4935_baaa_255763e2e8d1
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR DURAD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110035#
name: dihydrouracil dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110035#

metaR ECOAH9m
reactant: MODEL1310110035#
is described by: ECO:0000304
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110035#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR H2Otn
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: H2O transport, nuclear
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110035#

metaM HC02214 c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
name: prostaglandin-f1alpha

metaM pchol hs r
has only substance units: false
boundary condition: false
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: Phosphatidylcholine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_39d554b0_c151_4b8a_b2a1_152f14e2dbc1
type: Species
is: Q16850
name: CYP51A1
is encoded by: hsa:1595
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_d2dafaac_cb7f_4779_ba14_edfcd19d25a4
name: INPP5J
constant: false
is encoded by: hsa:27124
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_a0adf6bd_6f3e_4754_ba93_51703a9ea93a
has part: Q9BQL0
initial concentration: NaN
name: DBT:DLD:BCKDHA:BCKDHB
is encoded by: hsa:594
is: SBO:0000297
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_be24f625_804d_45bf_a7b7_380486285697
type: Species
constant: false
is: SBO:0000297
initial concentration: NaN
has only substance units: false
is encoded by: hsa:522
has part: Q6IB54
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true

metaR r1736
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2799C
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_84a7d50d_72b4_4945_969e_443b1a697383
initial concentration: NaN
is: P00390
boundary condition: true
name: GSR
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2936

metaR GLXtp
is described by: ECO:0000000
fast: false
type: Reaction
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_339d497a_93cd_493c_8b43_ba54e89b50d8
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7296
name: TXNRD1
has only substance units: false
initial amount: NaN
constant: false

metaM so4 c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: sulfate
has only substance units: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
is: CHEBI:16189

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_9ba0b6dc_1810_4eb3_aa30_ef85e3a46495
is: SBO:0000252
initial amount: NaN
name: ADA
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: P00813
is encoded by: hsa:100

metaR r1735
is: SBO:0000185
reversible: false
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_b3c9e39f_51b1_4650_a1e2_9098fc53400a
constant: false
type: Species
initial amount: NaN
name: PIGA
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5277

metaR AICART
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
fast: false
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaM prist c
is: HMDB00795
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial concentration: 1.0
initial amount: NaN
name: pristanic acid
is: CHEBI:51340
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM lneldccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247
boundary condition: false
is: HMDB06461
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: Linoelaidyl carnitine

metaR ETF
kinetic law: MODEL1310110035#
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000000
name: electron transfer flavoprotein
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
product: MODEL1310110035#
type: Reaction
fast: false

metaR r0616
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
fast: false

metaR BDMT L
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.142
type: Reaction
fast: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110035#

metaR r1590
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110035#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR ALAASNNaEx
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110035#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57449
type: Species
has only substance units: false
is: SBO:0000247
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
constant: false

metaR CLPNDCOAtx
name: fatty acid intracellular transport
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110035#

metaM pail3p hs c
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: CHEBI:58088
is: SBO:0000247

metaM HC00361 c
is: CHEBI:58335
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1d155f8d_3cfd_4213_896b_ca6eeb07a0a6
initial concentration: NaN
is encoded by: hsa:4023
constant: false
boundary condition: true
is: P06858
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: LPL

http://identifiers.org/biomodels.db/MODEL1310110035#_655f572f_68d1_4a26_b4e3_5f82a9a99bbc
is encoded by: hsa:53354
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PANK1
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_7cf7336e_7589_4eb2_b7d2_b21d121058fa
initial concentration: NaN
is encoded by: hsa:2544
has only substance units: false
name: _2544_1_c
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM glyb m
constant: false
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
initial amount: NaN
is: CHEBI:17750
name: glycine betaine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00043
has only substance units: false

metaR TAUBETAtc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by beta transport system
type: Reaction

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:15355
name: acetylcholine
is: HMDB00895
initial concentration: 1.0
constant: false

metaM prostgd2 r
initial amount: NaN
constant: false
type: Species
is: HMDB01403
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: prostaglandin D2(1-)
is: SBO:0000247

metaM pentcoa m
is: SBO:0000247
constant: false
is: HMDB13037
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: pentanoylcoa
boundary condition: false
is: C00888
notes: FORMULA: C26H40N7O17P3S CHARGE: -4

metaR r0617
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176

metaM leuktrA4 c
constant: false
is: CHEBI:57463
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01337
has only substance units: false
name: leukotriene A4(1-)

metaM hexc c
initial amount: NaN
constant: false
is: CHEBI:31013
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
is: HMDB02356
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: cerotate

metaR FAOXC163C142x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_2045b6e7_4be6_48bb_81f5_267c491a57bc
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q8N3E9
type: Species
is encoded by: hsa:113026
name: PLCD3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c60ac8e1_1f7c_4531_bee1_932b5733bd74
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: Q9Y666
type: Species
has only substance units: false
is encoded by: hsa:10723
name: SLC12A7
initial amount: NaN

metaR FAOXC225C226m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM for e
constant: false
has only substance units: false
name: formate
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15740
boundary condition: false
is: HMDB00142
initial concentration: 1.0

metaM 4mzym int2 r
is: HMDB06838
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: SBO:0000247
constant: false
initial amount: NaN
name: 4-Methylzymosterol intermediate 2
has only substance units: false

metaR r0614
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_f5d1f0c3_b2f9_4624_a4e6_773e6aa9293e
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC2A9
is encoded by: hsa:56606

metaR MAGt
name: monoacylglycerol 2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110035#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#

metaM etfrd m
has only substance units: false
type: Species
is: HMDB00145
initial amount: NaN
notes: FORMULA: RH2 CHARGE: 0
boundary condition: false
is: CHEBI:17263
name: Electron transfer flavoprotein reduced
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR GLXtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
name: glyoxylate transport, mitochondrial
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_2557f0e4_a350_4a40_be74_c51d06a1e424
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: SLC8A2
is encoded by: hsa:6543
is: Q9UPR5
type: Species
initial amount: NaN

metaR r1592
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR GGH 5DHFe
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
reversible: false

metaR MGSA
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
name: methylglyoxal synthase

http://identifiers.org/biomodels.db/MODEL1310110035#_4bdfa7ee_37d5_4403_b312_7a9a2fad9c2c
boundary condition: true
initial amount: NaN
name: CMPK1
is encoded by: hsa:51727
is: B2R6S5
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaM fe2 m
is: CHEBI:29033
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: Fe2+
is: SBO:0000247
boundary condition: false
is: HMDB00692
is: C00023

metaR AG13T12g
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
product: MODEL1310110035#

metaR r1591
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_6bec012f_224f_4f17_8275_f9ee12e3878a
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SULT1A3
initial concentration: NaN
constant: false
is encoded by: hsa:6818
boundary condition: true

metaR r0615
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
type: Reaction
reversible: true
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.168
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaR HAS2
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_f630cc2d_fa09_4571_b9dc_968141060ebe
is: Q9BZV2
type: Species
constant: false
is encoded by: hsa:80704
is: SBO:0000252
name: SLC19A3
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_8fd3fed9_b948_4cfc_8197_d0db7239c42b
constant: false
initial amount: NaN
name: HSD17B8
type: Species
is: Q92506
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7923

http://identifiers.org/biomodels.db/MODEL1310110035#_cb250944_4ca9_4ff9_a024_fd1fa13c082f
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: P22352
name: GPX3
is encoded by: hsa:2878

metaR M4MPDOL Lter
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: false
name: m4mpdol flippase
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM leuktrA4 e
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
name: leukotriene A4(1-)
has only substance units: false
is: HMDB01337
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57463
type: Species

metaM for c
constant: false
type: Species
name: Formate
boundary condition: false
initial amount: NaN
is: CHEBI:15740
is: C00058
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
has only substance units: false

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
name: Phosphatidylcholine
initial concentration: 1.0
has only substance units: false
is: CHEBI:16110
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaM ser L m
initial concentration: 1.0
is: CHEBI:17115
initial amount: NaN
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
type: Species
is: SBO:0000247
name: L-serine
boundary condition: false
constant: false

metaM amet m
is: HMDB01185
initial amount: NaN
is: CHEBI:15414
is: SBO:0000247
constant: false
name: S-Adenosyl-L-methionine
initial concentration: 1.0
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
boundary condition: false
has only substance units: false

metaR CYTK10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
name: cytidylate kinase (CMP,dGTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r2535
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaM thbpt c
type: Species
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
boundary condition: false
has only substance units: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
is: HMDB00027
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:15372

http://identifiers.org/biomodels.db/MODEL1310110035#_c82bfce1_1bfd_4c34_9aba_579403428277
is: Q13093
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7941
boundary condition: true
initial amount: NaN
type: Species
name: PLA2G7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR S6T1g
reversible: false
type: Reaction
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false

metaR UAG2EMAi
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false

metaR TETHEX3t
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110035#_d3a9a1eb_5302_4ae5_a44d_d8d463822efe
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:205
initial amount: NaN
type: Species
name: AK4

metaM so4 l
has only substance units: false
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
constant: false
name: sulfate
initial amount: NaN
is: HMDB01448
initial concentration: 1.0
is: CHEBI:16189

metaM glyald c
boundary condition: false
name: D-Glyceraldehyde
is: CHEBI:17378
is: HMDB01051
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00577
type: Species
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false

metaR r1594
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM hdcea e
is: HMDB03229
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: Hexadecenoate (n-C16:1)

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: retinoic acid transport
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_97609aa0_d3e5_43de_b70e_45586e91f439
name: UAP1
initial concentration: NaN
initial amount: NaN
constant: false
is: Q16222
is encoded by: hsa:6675
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_95518d33_4e4b_4d63_a547_6d618d7915e4
type: Species
name: ETNK1
initial amount: NaN
has only substance units: false
constant: false
is: Q9HBU6
is encoded by: hsa:55500
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR FAOXC123m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaM HC02202 c
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
type: Species
is: CHEBI:57398
name: prostaglandin A1(1-)
initial amount: NaN

metaM so4 m
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16189
constant: false
initial concentration: 1.0
initial amount: NaN
name: sulfate
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110035#_1b22fbc6_0dac_440e_9656_33ae25c60fee
is: P14410
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: SI
type: Species
initial amount: NaN
is encoded by: hsa:6476
has only substance units: false

metaR r1593
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110035#

metaR P5CR
name: pyrroline-5-carboxylate reductase
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000134
reversible: false

metaR CRNt
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
name: L-carnitine reversible transport
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110035#

metaM pail hs n
is: CHEBI:57880
constant: false
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
boundary condition: false

metaM datp c
boundary condition: false
is: CHEBI:61404
constant: false
name: dATP
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00131
is: HMDB01532

metaR CYTK12
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
fast: false
modifier: MODEL1310110035#

metaM ksi pre12 g
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 12
is: C00130
is: HMDB00175
type: Species
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
has only substance units: false
is: CHEBI:58053

metaR GLNASNNaEx
reversible: false
reactant: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110035#
is described by: ECO:0000269
modifier: MODEL1310110035#

metaR SERPT
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.50
kinetic law: MODEL1310110035#
reversible: false
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
name: serine C-palmitoyltransferase

metaM lneldccrn m
boundary condition: false
name: Linoelaidyl carnitine
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB06461
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial concentration: 1.0

metaR H3ETer
is described by: ECO:0000304
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false
is: SBO:0000176

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM h x
is: http://identifiers.org/pubchem.compound/3380
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
type: Species
is: C00080
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR r1596
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000

metaR HSPASEly
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
kinetic law: MODEL1310110035#

metaM hdcea c
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
is: SBO:0000247
constant: false
is: CHEBI:32372
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: Hexadecenoate (n-C16:1)

metaR r0909
fast: false
type: Reaction
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110035#

metaR GALt2 2
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
fast: false
reactant: MODEL1310110035#
type: Reaction
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000185
name: D-galactose transport via proton symport

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110035#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR 4NPHte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
name: xenobiotic transport
is described by: ECO:0000000
is: SBO:0000185

metaR CYTK11
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
name: cytidylate kinase (dCMP,dGTP)
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110035#_5123f727_8638_476b_8cb8_57d0244d6ce0
is encoded by: hsa:8527
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DGKD
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_67bb3501_23f5_43ab_8ccd_5e31f96dbedd
boundary condition: true
constant: false
is: Q13370
is: SBO:0000252
type: Species
is encoded by: hsa:5140
initial concentration: NaN
initial amount: NaN
name: PDE3B
has only substance units: false

metaR SGALSIDEtg
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: sgalside hs intracellular transport
fast: false

metaM HC01603 c
has only substance units: false
constant: false
is: C00234
type: Species
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_c8035d96_280f_4ee0_bb70_18a26f5148c9
has only substance units: false
is encoded by: hsa:4247
is: Q10469
constant: false
name: MGAT2
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_93e6f8c0_7f88_403d_818c_a4fcf241df84
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: DGKB
initial amount: NaN
is encoded by: hsa:1607
has only substance units: false
type: Species

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR r2141
fast: false
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110035#
type: Reaction
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM lnlncg e
is: SBO:0000247
is: HMDB03073
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:32391
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
has only substance units: false
initial amount: NaN

metaR r1595
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false

metaR FAOXC225C226x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaM 2decdicoa x
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,7-decadienoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e30188bf_dd8b_42b8_972a_a85bea115aaa
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P24311
is encoded by: hsa:1349
boundary condition: true
name: COX7B
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_af606429_540e_4e7c_aaf0_056ac09d2415
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: FUK
is: Q8N0W3
constant: false
is encoded by: hsa:197258
is: SBO:0000252
has only substance units: false
type: Species

metaR TYRPHELAT2tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM h r
is: C00080
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:24636

metaM HC01415 m
boundary condition: false
name: (2E)-Octenoyl-CoA
constant: false
is: CHEBI:27537
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM nrpphrsf e
boundary condition: false
constant: false
name: Sulfate derivative of norepinephrine
is: HMDB02062
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/123747

metaR CYTK14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110035#
is: SBO:0000176

metaR r2539
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
name: Postulated transport reaction

metaR FE3R2e
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
name: Fe(III) reduction (ascorbate)
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
product: MODEL1310110035#
type: Reaction
fast: false

metaR H2Otp
product: MODEL1310110035#
is: SBO:0000185
name: H2O transport, peroxisomal
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true

metaR NaKt
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
reversible: false
fast: false
product: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.3.9
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Na+/K+ exchanging ATPase

metaM ttdca c
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: myristate
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: HMDB00806
is: CHEBI:30807
initial amount: NaN

metaR r1598
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#

metaM amet r
is: SBO:0000247
boundary condition: false
constant: false
name: S-adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
has only substance units: false
is: CHEBI:15414
is: HMDB01185
initial concentration: 1.0
initial amount: NaN

metaR RE0944E
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110035#
name: RE0944
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110035#

metaR CYTK13
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
type: Reaction
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f13e93bf_b099_4506_abbb_439166609d9c
initial concentration: NaN
is: O43488
is: SBO:0000252
has only substance units: false
constant: false
name: AKR7A2
type: Species
initial amount: NaN
is encoded by: hsa:8574
boundary condition: true

metaM lnlncg c
initial amount: NaN
has only substance units: false
name: gamma-linolenate
boundary condition: false
is: CHEBI:32391
is: SBO:0000247
constant: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
type: Species

metaR r0354
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
is: SBO:0000176

metaM glyb e
is: SBO:0000247
initial amount: NaN
name: glycine betaine
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
is: HMDB00043
has only substance units: false
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6a128fda_2733_4cc1_96f5_65a91fd4cf8e
is: P48067
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6536
has only substance units: false
name: SLC6A9
initial amount: NaN

metaR r1597
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_4053fca9_5d4d_4980_b64a_c11318725154
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:115286
has only substance units: false
is: Q70HW3
name: SLC25A26

metaR RE2349C
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
fast: false
name: RE2349
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction

metaM cs e deg3 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00127
is: CHEBI:15748
type: Species

metaM Sfglutth c
is: HMDB01550
has only substance units: false
is: CHEBI:57688
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false
name: S-formylglutathionate(1-)
is: SBO:0000247

metaR r2537
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110035#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_62d57a2f_c0a5_43e5_a676_9274659c47b6
is encoded by: hsa:55512
is: A8K0T6
name: SMPD3
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_994b5d3d_cd4c_4555_96ab_0793d2083a4a
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:284273
is: Q4G1C4
name: ZADH2
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_431d2507_2cd4_4a49_9cdb_4f63d99d119e
name: GMPR2
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: Q86T14
constant: false
is encoded by: hsa:51292
initial amount: NaN
has only substance units: false

metaR TAURtcx
is: SBO:0000185
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
modifier: MODEL1310110035#
name: taurine transport (sodium symport) (cytosol to peroxisome)
type: Reaction
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB

metaM lneldccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
name: linoelaidyl coenzyme A
constant: false
is: HMDB06521
boundary condition: false
is: SBO:0000247

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR r1844
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaM tddedi2coa m
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
name: trans2,6dodecadienoylcoa
is: HMDB00672
type: Species
is: C08260
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_220cab12_1249_43b3_9289_51f76cb9932c
is: Q8IW54
boundary condition: true
name: PDE2A
initial amount: NaN
is encoded by: hsa:5138
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaM octd11ecoa m
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: 11-octadecenoylcoa
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06294
boundary condition: false
initial concentration: 1.0

metaR r2538
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true

metaR r1599
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_7ce79f32_2936_4e52_a1d1_b5182035a35e
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10195
name: ALG3
has only substance units: false
type: Species
initial concentration: NaN

metaM glyb c
type: Species
constant: false
name: glycine betaine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
is: CHEBI:17750
has only substance units: false
is: HMDB00043
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ffb601fd_6c2e_4522_8f95_e088adb40e46
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _AA788780_1_c
initial amount: NaN
is encoded by: hsa:AA788780
initial concentration: NaN
has only substance units: false

metaR SERTHRNaEx
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
product: MODEL1310110035#
reversible: false
is described by: ECO:0000269

metaR RE2079R
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
name: RE2079
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true
type: Reaction
fast: false

metaR r2361
type: Reaction
reversible: true
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaM h2o2 m
is: CHEBI:16240
is: C00027
is: HMDB03125
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
has only substance units: false
type: Species
is: SBO:0000247

metaR r1400
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110035#
is: SBO:0000185

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR S3TASE3ly
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is: SBO:0000176

metaR FACOAL200
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110035#

metaR SIAASE4ly
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110035#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction

metaR ALAGLNexR
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110035#
type: Reaction
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110035#

metaM 2hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02288
type: Species
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false

metaR r1589
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_903efea4_bf32_460f_b4ca_1b10c1f8efd8
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: PYGL
is: P06737
is encoded by: hsa:5836
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_45f82419_f419_413f_a605_40c2f27736df
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9ULD0
name: OGDHL
is encoded by: hsa:55753
initial concentration: NaN
type: Species
has only substance units: false

metaM fe2 c
type: Species
initial concentration: 1.0
is: CHEBI:29033
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
is: SBO:0000247
is: HMDB00692
is: C00023
name: Fe2+
has only substance units: false
constant: false

metaR r0345
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is described by: ECO:0000000
reversible: true
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110035#

metaR PROSTGD2t
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: true
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110035#

metaR r2362
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM ksi deg15 l
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
type: Species
boundary condition: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
name: keratan sulfate I, degradation product 15
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR P45039A1r
notes: GENE_ASSOCIATION: (51302.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - by analogy/similarity to xol hydrolase reactions (NADPH w/ O2 - NADH also noted to be cofactor if needed)
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.13.99
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: oxysterol 7-alpha-hydroxylase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_159691d6_b153_4492_a0f4_b44537a4ddae
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5498
boundary condition: true
initial concentration: NaN
is: P50336
is: SBO:0000252
constant: false
name: PPOX

metaR r0915
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
product: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000

metaM phe L c
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: L-phenylalanine
is: CHEBI:17295
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
is: HMDB00159

metaM dtmp m
has only substance units: false
boundary condition: false
is: C00364
initial amount: NaN
name: dTMP
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
is: CHEBI:26999
is: SBO:0000247
constant: false
is: HMDB01227

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
type: Reaction
name: RE3347
is: SBO:0000176
product: MODEL1310110035#
reversible: true

metaM dcmp c
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
is: C00239
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:57566
name: dCMP
initial amount: NaN
initial concentration: 1.0
is: HMDB01202

metaM coa x
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: Coenzyme A
initial concentration: 1.0
is: SBO:0000247
is: C00010
is: HMDB01423
boundary condition: false

metaM HC01405 m
initial amount: NaN
initial concentration: 1.0
type: Species
name: (S)-Hydroxyoctanoyl-CoA
constant: false
has only substance units: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
is: SBO:0000247
is: CHEBI:28632

metaR 3HKYNAKGAT
fast: false
product: MODEL1310110035#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110035#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110035#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7

http://identifiers.org/biomodels.db/MODEL1310110035#_8bff02d7_5849_4bc8_8dc7_8bc9b9e96c91
is: Q99755
initial amount: NaN
is encoded by: hsa:8394
constant: false
type: Species
boundary condition: true
has only substance units: false
name: PIP5K1A
initial concentration: NaN
is: SBO:0000252

metaR 13DAMPPOX
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110035#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000212
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
type: Reaction
product: MODEL1310110035#

metaR ASNtm
fast: false
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
name: L-asparagine transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110035#_0bb5251c_c3a4_47f5_b15e_6dba61bfcf8d
name: INPPL1
is encoded by: hsa:3636
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O15357
constant: false
is: SBO:0000252
type: Species

metaR r1020
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM sbt D c
name: D-glucitol
is: SBO:0000247
type: Species
is: CHEBI:17924
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
constant: false
is: HMDB00247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_f4ede15c_2ca2_49d5_9040_1dbf1cb22a9b
has only substance units: false
boundary condition: true
is: Q9NY65
is: SBO:0000252
is encoded by: hsa:1962
name: EHHADH
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1848
name: Y+LAT2 Utilized transport
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaR H2O2syn
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: Hydrogen peroxide synthesis (NADPH dependent)
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.6.3.1
is: SBO:0000176
reversible: false

metaM ttdca e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial amount: NaN
has only substance units: false
name: tetradecanoate (n-C14:0)
boundary condition: false
is: C06424
is: CHEBI:30807
is: HMDB00806
constant: false
type: Species

metaR r2360
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaM lnlncg l
boundary condition: false
is: HMDB03073
constant: false
type: Species
is: CHEBI:32391
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate
has only substance units: false
initial concentration: 1.0

metaR r0913
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM nrpphrsf c
is: http://identifiers.org/pubchem.compound/123747
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
has only substance units: false
name: Sulfate derivative of norepinephrine
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false

metaM gluside hs l
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:18368
constant: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
has only substance units: false
boundary condition: false

metaR FUT15g
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1

metaR UGALGTg
product: MODEL1310110035#
is: SBO:0000176
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110035#
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD

metaM pacald c
name: phenylacetaldehyde
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06236
is: CHEBI:16424

metaM phe L e
is: CHEBI:17295
is: HMDB00159
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaR PI4PP
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol-4-phosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#

metaM ac e
initial concentration: 1.0
constant: false
is: HMDB00042
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: SBO:0000247
is: CHEBI:30089
type: Species
has only substance units: false
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110035#_2871e0a2_a48b_430a_a999_0cfcdf4a2e42
is: F5H8B1
name: PCYT2
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5833
boundary condition: true

metaR RE1519M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: RE1519
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110035#
type: Reaction
fast: false

metaM leu L m
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
has only substance units: false
name: L-leucine
initial amount: NaN
constant: false
is: HMDB00687
is: CHEBI:15603

metaR MI1P Dtn
name: inositol 1-phosphate nuclear transport (diffusion)
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM methf c
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
has only substance units: false
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate
constant: false
is: C00445
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaR r2365
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110035#
fast: false
reversible: true

metaM ribflv c
is: C00255
constant: false
initial amount: NaN
name: Riboflavin
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244
boundary condition: false
is: SBO:0000247
is: CHEBI:3554

metaR ABUTD
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
name: Aminobutyraldehyde dehydrogenase
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
kinetic law: MODEL1310110035#

metaR FAOXC225C204x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM tethex3coa c
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
has only substance units: false
initial amount: NaN
is: C16168
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB06243
is: http://identifiers.org/pubchem.compound/47205478
name: tetracosahexaenoyl coenzyme A
is: SBO:0000247

metaM coa r
boundary condition: false
is: C00010
initial concentration: 1.0
is: CHEBI:57287
is: HMDB01423
name: Coenzyme A
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaM CE2416 x
name: (2R,6S,10S)-pristanate
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57923
initial concentration: 1.0
type: Species
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416

metaM ksii core4 deg2 l
has only substance units: false
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false
is: HMDB00143
type: Species
constant: false
is: SBO:0000247

metaR FAOXC184C164x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR NRVNCCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
type: Reaction

metaM lneldccoa m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01064
constant: false
name: linoelaidyl coenzyme A
type: Species
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_6ab209e0_d276_4f1c_bcc3_ced403595026
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: LDHA
is: P00338
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3939

metaM sbt D e
constant: false
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
name: D-glucitol
is: SBO:0000247

metaR FACOAL204
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true

metaM HC01397 x
name: (S)-3-Hydroxyhexadecanoyl-CoA
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
fast: false

metaR r2140
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110035#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_fed25d97_7aff_4b92_bd63_8d9fd4853fd7
initial amount: NaN
initial concentration: NaN
constant: false
name: COX6A1
is: P12074
boundary condition: true
is encoded by: hsa:1337
has only substance units: false
is: SBO:0000252
type: Species

metaM man1p c
has only substance units: false
is: CHEBI:35374
is: SBO:0000247
type: Species
constant: false
name: D-Mannose 1-phosphate
is: HMDB06330
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial concentration: 1.0
boundary condition: false

metaR LGTHL
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
name: lactoylglutathione lyase
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.4.1.5
reactant: MODEL1310110035#
is: SBO:0000176

metaM hs deg13 l
has only substance units: false
constant: false
is: HMDB06210
boundary condition: false
type: Species
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 13

http://identifiers.org/biomodels.db/MODEL1310110035#_86e621d2_bf3c_497b_8494_afdea4b13545
constant: false
initial concentration: NaN
name: BCKDHB
boundary condition: true
is: SBO:0000252
is encoded by: hsa:594
has only substance units: false
type: Species
initial amount: NaN
is: P21953

metaM pail hs c
is: CHEBI:57880
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
initial amount: NaN
boundary condition: false

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00042
is: CHEBI:30089
has only substance units: false
name: acetate
initial concentration: 1.0
type: Species
boundary condition: false

metaR FACOAL203
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#

metaM acgam6p c
is: HMDB01062
has only substance units: false
is: CHEBI:57513
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
type: Species
boundary condition: false

metaM ksi deg33 l
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 33
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: HMDB00143
is: CHEBI:12936
boundary condition: false

metaM ribflv e
is: C00255
name: Riboflavin
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:3554
constant: false
boundary condition: false
is: HMDB00244
initial concentration: 1.0
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110035#_56799f3f_cf0d_4555_8e11_919345a8e175
boundary condition: true
name: SULT1A1
is: SBO:0000252
type: Species
is encoded by: hsa:6817
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM lnlncacoa c
is: HMDB06290
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:51985
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
type: Species
name: alpha-Linolenoyl-CoA
initial amount: NaN
is: SBO:0000247

metaR r0033
product: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_11fcf883_a5fe_4738_8dc9_435f6f85fd8d
name: GUCY1A3
has only substance units: false
initial concentration: NaN
constant: false
is: D6RDW3
boundary condition: true
is encoded by: hsa:2982
is: SBO:0000252
initial amount: NaN
type: Species

metaM 4mzym int1 r
is: HMDB06927
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
name: 4-Methylzymosterol intermediate 1
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaR r2363
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR G14T21g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110035#_a1032af1_86af_48ca_9e9d_9a2324983a35
is: SBO:0000252
is: P11166
name: SLC2A1
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6513
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_4ca79b25_fff8_4c2d_a8e6_173e66d6ae94
is: SBO:0000252
is: Q96RV2
type: Species
has only substance units: false
name: HAS3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3038
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_eff95c8e_6e98_49a2_88df_8435d667b1ce
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC4A3
is encoded by: hsa:6508
type: Species
has only substance units: false
is: SBO:0000252

metaR G13MT L
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.132
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_03782afd_95e9_4eda_bc26_907e150ba28d
is: Q9UGH3
boundary condition: true
constant: false
is encoded by: hsa:9962
initial concentration: NaN
has only substance units: false
name: SLC23A2
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_af07b9d6_bef4_4a15_a217_5329bbb5cfde
initial amount: NaN
name: ACAA2
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:10449
is: P42765

http://identifiers.org/biomodels.db/MODEL1310110035#_ef11a38f_09cd_4e0e_9314_c2a914f371ee
has only substance units: false
type: Species
is: SBO:0000252
name: IDUA
boundary condition: true
is encoded by: hsa:3425
is: P35475
initial concentration: NaN
initial amount: NaN
constant: false

metaR FACOAL206
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110035#
name: fatty-acid--CoA ligase
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: true
reactant: MODEL1310110035#
is: SBO:0000176

metaM gluside hs r
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0917
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM glyald m
is: HMDB01051
is: SBO:0000247
boundary condition: false
is: CHEBI:17378
initial amount: NaN
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
has only substance units: false
type: Species
constant: false

metaR r2364
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_9f753c29_bf30_4f62_bf6f_a61c6c6d3ed4
name: SUCLA2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: E5KS60
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:8803

metaM tststerone r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
initial amount: NaN
is: HMDB00234
name: testosterone
constant: false
boundary condition: false
type: Species
is: CHEBI:17347

metaR S6T17g
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_ebb8f049_5136_4527_8610_4b830a1a1f55
name: HAL
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3034
initial amount: NaN
is: SBO:0000252
is: B4E0V8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d0d6538b_0d2f_4f40_b2b8_8bbabadcf1f4
constant: false
name: GCK
is: P35557
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2645

metaR FACOAL205
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110035#
name: fatty-acid--CoA ligase

metaR 3MOBte
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110035#
fast: false
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true

metaM xu1p D c
name: D-Xylulose 1-phosphate
constant: false
is: HMDB06534
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR DIDPtn
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR RE2626M
modifier: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: RE2626
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_1223c913_3a36_4734_b3be_3d95d6fe8938
is: P14672
is encoded by: hsa:6517
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: SLC2A4
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR FAOXC122x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000134
name: glutathione peroxidase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
product: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_206f405d_0065_4c93_8bb3_e7f9e8392873
is encoded by: hsa:AA854479
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _AA854479_1_m
constant: false
is: SBO:0000252

metaR DESAT16 2
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
is described by: ECO:0000000
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110035#
reversible: false
is: SBO:0000176
type: Reaction

metaM gluside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

metaR 5ADTSTSTERONESte
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110035#
is: SBO:0000185
name: sulfonated testosterone transport
type: Reaction

metaM coa n
is: HMDB01423
type: Species
constant: false
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
boundary condition: false
is: CHEBI:57287
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7e9e5aff_8a86_4a77_903a_52c615f51745
type: Species
initial concentration: NaN
is encoded by: hsa:28976
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: ACAD9
is: Q9H845

metaM pchol hs g
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
name: Phosphatidylcholine
is: CHEBI:16110
type: Species
initial concentration: 1.0
has only substance units: false

metaR r2369
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110035#
type: Reaction

metaM leu L c
name: L-leucine
is: CHEBI:15603
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00687
has only substance units: false

metaR GTHO
reversible: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
fast: false
product: MODEL1310110035#
name: glutathione oxidoreductase

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaR PRASCS
modifier: MODEL1310110035#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.3.2.6
type: Reaction
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110035#
fast: false
is: SBO:0000176

metaM h2o2 c
is: HMDB03125
constant: false
name: Hydrogen peroxide
is: CHEBI:16240
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00027

metaR FAOXC161802m
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaM xan c
is: HMDB00292
is: CHEBI:17712
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00385
initial amount: NaN
type: Species
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385

metaM dtmp e
type: Species
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP(2-)
initial concentration: 1.0
is: CHEBI:26999
has only substance units: false
is: SBO:0000247
is: HMDB01227
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fcc8a2d4_b0eb_4f57_a869_5449f7a20a50
is encoded by: hsa:2523
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: FUT1
has only substance units: false
initial amount: NaN
is: Q6IZA2

metaR RE3272N
fast: false
name: RE3272
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaM ura e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
initial amount: NaN
is: HMDB00300
boundary condition: false
constant: false
is: CHEBI:17568
name: uracil
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_f7b7b50a_fabd_4d0c_b5e1_135882467066
has only substance units: false
is encoded by: hsa:2348
boundary condition: true
initial concentration: NaN
name: FOLR1
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaM HC02203 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: CHEBI:27820
has only substance units: false
constant: false
name: prostaglandin-a2
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_8bb77d76_3b52_49f2_b9dc_0e69a6322159
is: Q9NX14
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:54539
name: NDUFB11

metaR CSAPASEly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110035#
fast: false
reversible: false

metaR CSPG Atly
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
name: chondroitin sulfate A transport, extracellular to lysosome
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR TETPENT6COAtx
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
fast: false
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000

metaR GPIAT
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: glucosaminylphosphatidyl inositol acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110035#_5588832e_014c_466b_bd19_ec4710ba32b6
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: Q38G75
boundary condition: true
initial concentration: NaN
name: GALE
is encoded by: hsa:2582

metaR SQLEr
type: Reaction
reactant: MODEL1310110035#
name: Squalene epoxidase, endoplasmic reticular (NADP)
is version of: http://identifiers.org/ec-code/1.14.13.132
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000134
reversible: false
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM cyan m
name: hydrogen cyanide
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18407
type: Species
is: HMDB02084
has only substance units: false
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
is: SBO:0000247

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

MODEL1310110035
reaction: metaR r0475
species: metaM ksi deg26 l
reaction: metaR r1647
reaction: metaR sink pre prot LPAREN r RPAREN
reaction: metaR ALCD21 D
reaction: metaR ETHAK
species: metaM xol7ah2al m
species: metaM ksii core2 pre5 g
reaction: metaR GLCAASE1ly
reaction: metaR r2092
reaction: metaR LGTHL
species: metaM sphings l
reaction: metaR EX 34hpp
species: metaM cit c
species: metaM mi14p c
species: metaM oh1 c
reaction: metaR VALt5m
reaction: metaR EX Rtotal3 LPAREN e RPAREN
reaction: metaR r2084
reaction: metaR r1681
reaction: metaR ACGALtly
reaction: metaR ADKd
species: metaM val L e
species: metaM dcmp n
species: metaM taur e
reaction: metaR S6TASE24ly
reaction: metaR PSDm hs
species: metaM hyptaur c
species: metaM pail4p hs n
reaction: metaR G14T2g
reaction: metaR 4HPRO LTte
reaction: metaR NADtn
reaction: metaR EX leuleu LPAREN e RPAREN
species: metaM uacgam c
species: metaM hexdiac r
reaction: metaR FACOAL245 1
reaction: metaR NTP3e
reaction: metaR F1PGT
reaction: metaR BAMPPALDOX
species: metaM val L c
reaction: metaR DOLPMT L
species: metaM ttdca e
species: metaM prostgh2 e
species: metaM 3oddcoa x
species: metaM gpi hs r
species: metaM 1glyc hs e
reaction: metaR r1736
reaction: metaR r1588
reaction: metaR NACHEX27ly
reaction: metaR B3GNT39g
species: metaM dsmsterol r
reaction: metaR ADSK
reaction: metaR AMANK
reaction: metaR 3AIBtm
reaction: metaR r2353
reaction: metaR GALASE20ly
reaction: metaR CSNATm
reaction: metaR SRTNt6 2 r
reaction: metaR DOPASFt
reaction: metaR ESTRONEtr
reaction: metaR EX lnlnca LPAREN e RPAREN
species: metaM strch2 e
reaction: metaR r2327
reaction: metaR PROSTGE1t
species: metaM camp c
species: metaM HC01104 e
reaction: metaR GALASE14ly
reaction: metaR PPDOx
reaction: metaR S6TASE21ly
reaction: metaR G12MT2 L
reaction: metaR CSPG Etly
species: metaM ksi pre11 g
species: metaM dcyt c
reaction: metaR q10tm
species: metaM mag hs c
reaction: metaR FAOXC164C143x
species: metaM biliverd c
reaction: metaR EX tetpent6 LPAREN e RPAREN
reaction: metaR LINOFATPtc
reaction: metaR EX 10fthf5glu LPAREN e RPAREN

metaR SCP21x
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: Sterol carrier protein 2
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110035#
reactant: MODEL1310110035#

metaR H2Otg
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110035#
name: H2O transport, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110035#_d33c133c_ce36_43c5_afe5_d480aa70b35f
boundary condition: true
has only substance units: false
initial amount: NaN
name: ACSL6
is: B2RB13
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:23305
type: Species

metaR r2367
kinetic law: MODEL1310110035#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110035#_d47ee632_043f_430c_8a2a_555054b39b8a
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:498
name: ATP5A1
is: A8K092

metaM leu L e
has only substance units: false
constant: false
name: L-leucine
is: CHEBI:15603
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
initial concentration: 1.0
boundary condition: false

metaM ksi pre27 g
is: HMDB00175
initial amount: NaN
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 27
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
constant: false

metaM h2o2 e
name: hydrogen peroxide
is: SBO:0000247
is: HMDB03125
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0456
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
product: MODEL1310110035#
type: Reaction
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110035#
fast: false

metaR LINKDEG2ly
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR G14T14g
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is described by: ECO:0000000

metaR FERO
modifier: MODEL1310110035#
fast: false
is: SBO:0000176
name: ferroxidase
product: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110035#

metaM HC02203 c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
is: CHEBI:27820
initial amount: NaN
name: prostaglandin-a2
type: Species
constant: false

metaM aprgstrn c
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (20S)-20-hydroxypregn-4-en-3-one
boundary condition: false
is: CHEBI:28453
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
initial amount: NaN
constant: false
is: HMDB03069

metaM ura c
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: C00106
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00300
is: CHEBI:17568
initial concentration: 1.0
constant: false
has only substance units: false

metaR r2368
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110035#

metaR COt
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: CO transporter via diffusion
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
reversible: true

metaR URCN
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.49
reversible: false
modifier: MODEL1310110035#
name: URCN
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110035#

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
is: HMDB02288
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaR OCD11CRNCACT
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM coa m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00010
is: SBO:0000247
name: Coenzyme A
is: CHEBI:57287
initial amount: NaN
is: HMDB01423
type: Species
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM hs deg5 l
boundary condition: false
is: HMDB00158
has only substance units: false
is: CHEBI:17895
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11

metaR ORPT
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
name: orotate phosphoribosyltransferase
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110035#

metaR SCPx
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
name: peroxisomal thiolase 2

metaM dgcholcoa x
is: SBO:0000247
has only substance units: false
is: HMDB06897
name: Chenodeoxyglycocholoyl-CoA
constant: false
initial amount: NaN
is: C05461
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461

metaM galgalgalthcrm hs e
type: Species
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
is: CHEBI:0
initial amount: NaN
is: SBO:0000247
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: HMDB00143
initial concentration: 1.0
is: C00124
constant: false
has only substance units: false
boundary condition: false

metaR PI4P3K
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.154

metaR r1698
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaM gluside hs g
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
type: Species
is: CHEBI:18368
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaM cs b deg2 l
is: CHEBI:16953
is: HMDB00812
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
notes: FORMULA: C37H54NO41S3 CHARGE: -5
constant: false

metaM pchol hs c
name: Phosphatidylcholine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:16110
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b57caef7_d839_46a9_9b58_c18bba2fb89f
has part: P23378
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2653
initial amount: NaN
has part: P23434
is: SBO:0000297
is encoded by: hsa:275
is encoded by: hsa:2731
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
has part: P48728
type: Species

metaM grdp x
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
boundary condition: false
name: geranyl diphosphate(3-)
is: CHEBI:58057
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

metaM ksi pre34 g
type: Species
is: CHEBI:58053
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
is: C00130
is: HMDB00175
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C241H385N17O202S10X CHARGE: -11

metaM hdcea r
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB03229
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32372
constant: false
has only substance units: false
name: palmitoleate
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

http://identifiers.org/biomodels.db/MODEL1310110035#_dce6f7f7_a81b_49fb_a9ae_1ec894c9f3d6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: ACOX3
boundary condition: true
is: O15254
has only substance units: false
is encoded by: hsa:8310

metaM aprgstrn e
name: (20S)-20-hydroxypregn-4-en-3-one
boundary condition: false
type: Species
is: CHEBI:28453
initial amount: NaN
is: HMDB03069
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_12b1a7f0_e984_4d5f_954a_4a25e1812018
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5332
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PLCB4
is: Q15147

metaR RTOTALt
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110035#
name: RTOTAL transport

http://identifiers.org/biomodels.db/MODEL1310110035#_e868c729_fd11_4094_b6f5_928dbf6b2a00
initial concentration: NaN
constant: false
type: Species
name: GBA
is: B7Z5G2
is encoded by: hsa:2629
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR KSII CORE2tly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110035#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: false

metaM gar c
has only substance units: false
is: HMDB02022
is: CHEBI:58457
constant: false
type: Species
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: C03838
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_0eedc3fb_668f_49b1_a77f_a7bea0b774bd
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: Q16348
initial concentration: NaN
has only substance units: false
name: SLC15A2
is encoded by: hsa:6565

metaR It
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: Iodide uniport
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_160b295b_3438_433d_9a11_ff616255117a
initial amount: NaN
has only substance units: false
name: PTGDS
initial concentration: NaN
is encoded by: hsa:5730
is: SBO:0000252
boundary condition: true
type: Species
is: P41222
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_435fd6b5_bbcf_4417_9467_ee66b0d80eca
initial concentration: NaN
is: P02730
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: SLC4A1
is encoded by: hsa:6521
initial amount: NaN
constant: false

metaM octa e
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
initial amount: NaN
constant: false
type: Species
name: octanoate (n-C8:0)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00482
is: C06423
has only substance units: false

metaR r0911
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaM thr L c
initial amount: NaN
is: CHEBI:16857
initial concentration: 1.0
is: HMDB00167
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
name: L-threonine
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaR FAOXC225C204m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_1f6ccef2_2ae8_4bf0_a504_94d5fa85a45a
type: Species
initial concentration: NaN
is encoded by: hsa:5372
boundary condition: true
initial amount: NaN
name: PMM1
is: SBO:0000252
is: A8K003
constant: false
has only substance units: false

metaM lnlncg r
boundary condition: false
is: HMDB03073
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: gamma-linolenate

metaM ipdp x
type: Species
name: isopentenyl diphosphate(3-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01347
is: CHEBI:128769

metaM galgalgalthcrm hs g
is: CHEBI:26174
boundary condition: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
constant: false
initial concentration: 1.0
type: Species

metaM pchol hs e
constant: false
name: Phosphatidylcholine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
boundary condition: false
type: Species

metaM methf m
is: HMDB01354
is: SBO:0000247
is: CHEBI:57455
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_9251eb72_69b2_4a98_8b67_7e526d312950
initial amount: NaN
initial concentration: NaN
constant: false
has part: B4E3E9
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX
is: SBO:0000297
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_cf95ab5a_0ac4_415a_9e96_a375701bf933
initial amount: NaN
type: Species
is encoded by: hsa:521
is: P56385
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5I
has only substance units: false

metaR DOLPMT4 Uer
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_fec5752f_7416_4666_ae63_07074d262367
initial amount: NaN
type: Species
name: SLCO4A1
is: SBO:0000252
constant: false
has only substance units: false
is: Q96BD0
initial concentration: NaN
is encoded by: hsa:28231
boundary condition: true

metaM octa c
is: HMDB00482
name: octanoate (n-C8:0)
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C06423
is: CHEBI:25646
notes: FORMULA: C8H15O2 CHARGE: -1

metaM dtmp c
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:26999
name: dTMP
initial concentration: 1.0
is: HMDB01227

http://identifiers.org/biomodels.db/MODEL1310110035#_32516e4b_716b_409f_9152_56310fee80dc
is: SBO:0000252
constant: false
is encoded by: hsa:6541
type: Species
name: SLC7A1
has only substance units: false
initial amount: NaN
is: P30825
boundary condition: true
initial concentration: NaN

metaM amet c
boundary condition: false
has only substance units: false
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
name: S-Adenosyl-L-methionine
is: CHEBI:15414
constant: false
is: SBO:0000247
is: C00019
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_6cbeea46_4ae4_4d4f_b782_cc94b6480f66
name: PIP5K1B
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: O14986
is encoded by: hsa:8395

http://identifiers.org/biomodels.db/MODEL1310110035#_da4c6d97_95c0_425a_b45a_03dd81259210
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2109
name: ETFB
initial concentration: NaN

metaM fe2 e
is: HMDB00692
is: C00023
name: Fe2+
is: CHEBI:29033
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaR TYMSFt
product: MODEL1310110035#
type: Reaction
name: Tyramine O-sulfate transport (diffusion)
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110035#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_6ddb1ed8_bde2_4d21_b93a_7f3ce3098f6c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1593
name: CYP27A1
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: Q02318
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_5941cf5d_cc64_4dd3_b844_d507ccd7fa24
is: P15531
initial concentration: NaN
name: NME1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4830
has only substance units: false
constant: false

metaM thr L e
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is: HMDB00167
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16857
name: L-threonine
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_a6714a9b_7c50_4ddf_a14f_950b045a3b40
type: Species
has part: B4DY56
is encoded by: hsa:498
constant: false
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
initial amount: NaN
has only substance units: false
boundary condition: true

metaR GACPAILter
name: glucosaminyl-acylphosphatidylinositol ER flippase
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_e785a019_ef7c_494d_a269_4be3dfd8495c
is: SBO:0000252
is encoded by: hsa:5315
type: Species
has only substance units: false
name: PKM2
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaR r0472
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ebdb8e21_a852_4dc4_8a35_e226ca65acae
initial concentration: NaN
initial amount: NaN
is: P18283
constant: false
is: SBO:0000252
name: GPX2
boundary condition: true
is encoded by: hsa:2877
type: Species
has only substance units: false

metaM 3docopencoa x
boundary condition: false
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_b8f9c69f_5549_4858_9b23_7d8ce727adf4
is: O14734
name: ACOT8
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10005
initial amount: NaN

metaM pcrn m
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
name: propionyl-carnitine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
is: HMDB00824

http://identifiers.org/biomodels.db/MODEL1310110035#_27028046_26d4_433b_b2be_1e27b13fb5a0
constant: false
name: DCK
is: P27707
initial amount: NaN
is encoded by: hsa:1633
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR KSItly
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: false
name: keratan sulfate I transport, extracellular to lysosome
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction

metaR OMHPALTD
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_76026202_b683_4998_bad5_3472dcde8e03
constant: false
name: HSD17B4
is encoded by: hsa:3295
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: E9PB82

metaM chol c
has only substance units: false
is: HMDB00097
is: CHEBI:15354
boundary condition: false
name: Choline
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR B3GNT32g
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110035#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_1805f067_fdc2_4987_bdb8_55993312742d
initial amount: NaN
name: AGL
constant: false
has only substance units: false
is encoded by: hsa:178
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_00eebd38_a353_4d0d_80d4_1131238d41bb
is encoded by: hsa:3906
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: LALBA
boundary condition: true
type: Species
is: P00709
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_26f63ace_dfa5_4628_8ad7_cd049500bace
is: SBO:0000252
is: B7Z9T9
boundary condition: true
is encoded by: hsa:5158
initial concentration: NaN
name: PDE6B
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
is: CHEBI:57847
has only substance units: false
name: Type IIIA glycolipid
type: Species
boundary condition: false
is: HMDB00304
is: SBO:0000247
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false

metaR r0083
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
reversible: true
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9010c094_3fc0_4ef2_8370_d50ccec55b91
is: SBO:0000252
constant: false
name: PLCXD2
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q0VAA5
is encoded by: hsa:257068

metaR r2137
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false

metaM etfox m
name: Electron transfer flavoprotein oxidized
type: Species
is: HMDB00145
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: R CHARGE: 0
constant: false
boundary condition: false
is: CHEBI:17263
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a20f30b4_594e_4780_81d3_8a04e5af50f0
is: SBO:0000252
type: Species
initial amount: NaN
name: HSD17B4
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82

metaR VD3
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
name: Vitamin D3 formation
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000134

metaR PRISTtx
is described by: ECO:0000000
product: MODEL1310110035#
name: prist peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_612aafe7_fcd7_402f_93d2_d83f32956b33
type: Species
boundary condition: true
is encoded by: hsa:196883
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: ADCY4
is: Q8NFM4
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_e6a7bf29_09ef_4816_ad11_f4b35d4a0f55
is: A1L4Q0
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:8526
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: DGKE

http://identifiers.org/biomodels.db/MODEL1310110035#_4bc27406_200a_4adc_9649_ec8c8fe1d74e
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFA8
is encoded by: hsa:4702
has only substance units: false
is: B1AM93
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_b5786fbb_9574_4dba_ab0d_8c89420e06a5
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:5052
initial amount: NaN
name: PRDX1
initial concentration: NaN
constant: false

metaM nadp c
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58349
boundary condition: false
is: HMDB00217
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: C00006

metaM pmtcrn m
boundary condition: false
name: L-palmitoylcarnitine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17490
is: HMDB00222
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR DNDPt27m
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: dCDP transport via dTDP antiport
modifier: MODEL1310110035#
reversible: false
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction

metaR FAOXC163C164x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaM cyan e
constant: false
is: CHEBI:18407
is: HMDB02084
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b3efb62c_98c8_4c99_829c_7e57b3a749ed
is: SBO:0000252
is encoded by: hsa:54675
boundary condition: true
initial concentration: NaN
is: Q9UJA2
type: Species
initial amount: NaN
name: CRLS1
constant: false
has only substance units: false

metaR GALSGLT1le
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR NADPHtxu
name: NADPH transporter, peroxisome
reversible: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
kinetic law: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c9c4fabc_9285_4112_b9b8_3c5143f72e68
is: SBO:0000252
is encoded by: hsa:54511
constant: false
name: HMGCLL1
is: Q9NT06
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r0474
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110035#_41b254a4_5371_4342_b166_3261b1bdc725
is encoded by: hsa:122622
initial amount: NaN
type: Species
is: Q8N142
name: ADSSL1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaM malthp e
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
has only substance units: false
name: maltoheptaose
is: C01936
boundary condition: false
constant: false
initial amount: NaN

metaR r1726
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport

metaR GALtly
name: galactose efflux from lysosome
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110035#

metaM tre e
is: C01083
has only substance units: false
is: HMDB00975
type: Species
is: SBO:0000247
initial amount: NaN
name: Trehalose
constant: false
initial concentration: 1.0
is: CHEBI:16551
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_06b9ea25_5cbb_4fd1_a6b7_ef3f7a5fb8be
is encoded by: hsa:AI824319
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI824319_1_r
type: Species
initial concentration: NaN
is: SBO:0000252

metaR GluForTx
is: SBO:0000176
reversible: false
name: Glutamate formimidoyltransferase
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000269
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB

metaM ksii core2 deg2 l
constant: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: HMDB00143
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:12936

metaM 4hpro LT m
boundary condition: false
is: HMDB00725
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: trans-4-hydroxy-L-proline
type: Species
constant: false
initial amount: NaN
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

http://identifiers.org/biomodels.db/MODEL1310110035#_bb9b9fee_079c_4b45_bbfe_03d037102a87
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: HSD17B4
is encoded by: hsa:3295
initial concentration: NaN
is: SBO:0000252
is: E9PB82

metaR BTNt4i
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110035#
is described by: ECO:0000269
reversible: false
name: Biotin uptake (antiport)
product: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e341b740_7b60_483b_9f7c_3ab5d0263c66
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI469183
is: SBO:0000252
type: Species
constant: false
name: _AI469183_1_x
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_23778f3d_8f95_46a9_8df6_e8abb6a5a7ed
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:56922
initial concentration: NaN
is: SBO:0000252
name: MCCC1
constant: false
is: Q96RQ3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
is: CHEBI:15347
initial concentration: 1.0
is: HMDB01659
boundary condition: false

metaR AG13T11g
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR r0081
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
type: Reaction
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR r0475
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110035#
is: SBO:0000176

metaM msa m
initial amount: NaN
type: Species
name: 3-oxopropanoate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
constant: false
initial concentration: 1.0
is: CHEBI:33190
has only substance units: false
is: HMDB11111

metaR r1725
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaM cyan c
is: CHEBI:18407
constant: false
name: hydrogen cyanide
initial concentration: 1.0
is: HMDB02084
boundary condition: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR C3STKR2r
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000134
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reactant: MODEL1310110035#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110035#

metaM cs e deg2 l
is: HMDB00812
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16953
boundary condition: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
initial concentration: 1.0
initial amount: NaN

metaR A4GALTg
modifier: MODEL1310110035#
name: Lactosylceramide 4-alpha-galactosyltransferase
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.228
fast: false
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR r2139
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_9902aa80_86f9_4c89_b626_b79c192b88e2
type: Species
initial concentration: NaN
boundary condition: true
name: _M68895_1_c
is encoded by: hsa:M68895
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaM biocyt e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
constant: false
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
is: HMDB03134
is: SBO:0000247
initial amount: NaN
is: C05552
type: Species
boundary condition: false

metaR BILDGLCURt
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110035#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
is: SBO:0000185

metaR RE1807C
kinetic law: MODEL1310110035#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_d13457ad_d8ff_484a_84d5_80b8ccedda53
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3613
name: IMPA2
boundary condition: true
initial concentration: NaN
is: O14732
type: Species
constant: false

metaM ppa e
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: CHEBI:17272
initial concentration: 1.0
constant: false
is: HMDB00237
initial amount: NaN
name: propionate

metaM mal L m
name: (S)-malate(2-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
constant: false
is: CHEBI:15589
initial concentration: 1.0
is: HMDB00156
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3defcda7_6948_4822_b735_a9d9d881a29a
boundary condition: true
name: IDH2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:3418
is: P48735
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_aba09a37_f2d4_482b_82ab_bcbfa29341e0
constant: false
initial amount: NaN
has only substance units: false
name: _AA526438_1_m
boundary condition: true
is encoded by: hsa:AA526438
is: SBO:0000252
type: Species
initial concentration: NaN

metaM ps hs e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
type: Species
name: phosphatidylserine
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR 4ABUTtm
product: MODEL1310110035#
name: 4-aminobutanoate mitochondrial transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reactant: MODEL1310110035#

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110035#
reversible: false
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false

metaM lald D c
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06458
initial amount: NaN
is: CHEBI:17167
initial concentration: 1.0
constant: false

metaM chol g
is: HMDB00097
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
has only substance units: false
is: CHEBI:15354

metaM pmtcrn r
name: L-palmitoylcarnitine
boundary condition: false
type: Species
is: CHEBI:17490
constant: false
is: HMDB00222
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_b9a223f3_4a7c_41f4_9d83_dbc71f829f29
is encoded by: hsa:6648
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: P04179
name: SOD2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_a851b06b_3cfa_43fb_81d6_61525e1ab505
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: ACSL5
is: Q9ULC5
is encoded by: hsa:51703
constant: false
initial concentration: NaN

metaR HMGCOASim
reversible: false
type: Reaction
reactant: MODEL1310110035#
name: Hydroxymethylglutaryl CoA synthase (ir)
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_19e20f13_5bc1_4139_b4cb_04fe00198a0b
is: SBO:0000252
type: Species
is encoded by: hsa:2629
boundary condition: true
name: GBA
initial amount: NaN
has only substance units: false
is: P04062
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4375a77e_53dd_493b_9e3e_38cc7004db02
name: ACOX2
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8309
is: SBO:0000252
initial amount: NaN
constant: false
is: Q99424
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_1f138f2a_5768_4b80_b63b_6316b77ce77d
type: Species
is: SBO:0000252
name: _AI373818_1_m
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI373818
initial amount: NaN

metaR r0627
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
type: Reaction
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#

metaM thmpp m
is: CHEBI:45931
is: SBO:0000247
type: Species
constant: false
is: HMDB01372
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Thiamine diphosphate
initial amount: NaN
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: HMDB06211
initial concentration: 1.0
is: C04640
constant: false
is: CHEBI:58478

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_123c9712_99c5_42fd_a733_201937812d62
has only substance units: false
initial concentration: NaN
name: ADSL
is: SBO:0000252
constant: false
is: P30566
boundary condition: true
initial amount: NaN
is encoded by: hsa:158
type: Species

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR Htg
kinetic law: MODEL1310110035#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR CHOLD2m
fast: false
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.1
is described by: ECO:0000269
name: choline dehydrogenase (FAD acceptor), mitochondrial
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
type: Reaction

metaR PROGLYPRO1c
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of glycylproline in the small intestine for cellular uptake
type: Reaction

metaM ppa c
is: HMDB00237
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: propionate
is: CHEBI:17272
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e02bae17_ccc1_49d3_8938_2d26b4f9ff04
is: Q96P26
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:93034
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NT5C1B

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03125
has only substance units: false
is: CHEBI:16240
is: C00027
initial amount: NaN
boundary condition: false
constant: false

metaM chol e
is: SBO:0000247
is: HMDB00097
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Choline
type: Species
is: C00114
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: CHEBI:15354

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.61
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: false
modifier: MODEL1310110035#
type: Reaction
fast: false
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110035#_b79459c4_a423_4266_a420_7b24ff419dde
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN
constant: false
type: Species
name: PDE9A
boundary condition: true
has only substance units: false
initial amount: NaN

metaM m8masn r
constant: false
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: C05876
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM psyl e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB11178
boundary condition: false
name: psyllium
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_39e72a0a_94e2_4786_be51_9fd4a52662ef
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:160287
boundary condition: true
name: LDHAL6A
is: Q6ZMR3

metaR LNELDCCRNt
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reversible: false
modifier: MODEL1310110035#

metaR RE0958E
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110035#
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
type: Reaction

metaR r0629
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.6.1.22

metaM ps hs c
is: SBO:0000247
name: ps_hs[c]
is: CHEBI:18303
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
constant: false

metaR FAOXC142C122x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_ef427a9a_502c_4b8c_af5b_daa88e2f4074
name: SLC8A3
constant: false
initial amount: NaN
is encoded by: hsa:6547
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR SPHINGStl
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
reversible: true
name: sphingosine intracellular transport

metaM xol27oh m
initial amount: NaN
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: 26-hydroxycholesterol
is: HMDB02103
constant: false
has only substance units: false

metaR r0774
modifier: MODEL1310110035#
fast: false
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM cmpacna n
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM dcmp n
is: HMDB01202
type: Species
name: dCMP(2-)
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_5cc3835c_3170_4b37_9cd1_95194e796eb7
is: Q96SL4
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: GPX7
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2882

metaM occoa x
is: HMDB01070
constant: false
type: Species
is: SBO:0000247
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_65f13927_4654_4a8c_93b6_bae7e80ef37a
type: Species
is: B7Z6M3
name: DGKZ
has only substance units: false
is encoded by: hsa:8525
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_68edbed9_d008_4be8_b68c_3efa21b79bd8
initial concentration: NaN
is: SBO:0000252
is: Q9UHK6
name: AMACR
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:23600
initial amount: NaN

metaM cmpacna g
is: HMDB01176
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species

metaM acnamp c
boundary condition: false
is: SBO:0000247
is: HMDB06268
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
name: N-Acetylneuraminate 9-phosphate
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:27438

http://identifiers.org/biomodels.db/MODEL1310110035#_2a4aeac9_0aae_4114_9161_be06e57b020d
boundary condition: true
is encoded by: hsa:109
has only substance units: false
is: B3KT86
name: ADCY3
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_3aff5588_4f0f_42b6_9e22_662a3b12ee07
is: F8VQS7
type: Species
initial concentration: NaN
constant: false
name: NDUFA12
is encoded by: hsa:55967
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR CSPG Btly
is described by: ECO:0000000
product: MODEL1310110035#
reversible: false
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110035#

metaR r2521
product: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110035#
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110035#

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110035#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM glc D e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00122
boundary condition: false
is: CHEBI:4167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_86f59dfc_d012_4972_bb38_cb496ba0438b
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O75355
type: Species
is encoded by: hsa:956
constant: false
name: ENTPD3

http://identifiers.org/biomodels.db/MODEL1310110035#_e088e817_6779_4900_9b28_82f1b8007799
is encoded by: hsa:3945
name: LDHA:LDHB
is: SBO:0000297
boundary condition: true
has part: P07195
constant: false
has part: P00338
initial concentration: NaN
is encoded by: hsa:3939
has only substance units: false
type: Species
initial amount: NaN

metaR NAHCO3 HCLt
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269
fast: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reversible: true
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_73d58914_6ef3_4d8d_bc6b_077ecd501a43
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: A8K9Q8
name: B3GNT6
is encoded by: hsa:192134
constant: false
has only substance units: false

metaM ksi deg34 l
type: Species
is: SBO:0000247
is: HMDB00812
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16953
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 34

http://identifiers.org/biomodels.db/MODEL1310110035#_9a452431_da86_430f_adc6_5dcddea70012
name: HMGCR
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3156
constant: false
initial amount: NaN
is: P04035
boundary condition: true
has only substance units: false

metaR FAEL183
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_cad8376f_0c32_426e_a830_cc225451a23e
type: Species
initial amount: NaN
is encoded by: hsa:8398
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: A8K460
name: PLA2G6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_35f2ce98_bedb_4f71_9990_fc88f0f23b4a
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:376497
name: SLC27A1
has only substance units: false
constant: false
initial amount: NaN

metaM HC01104 e
initial amount: NaN
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
type: Species
is: CHEBI:61146
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0360
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000000
type: Reaction
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: blood group intracellular transport
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_77bcc720_8c01_4b2c_b4c5_03720d38c8e0
initial amount: NaN
boundary condition: true
is encoded by: hsa:57665
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: RDH14
is: Q9HBH5
constant: false

metaR SUCD1m
is described by: ECO:0000134
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
type: Reaction
name: succinate dehydrogenase
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_66cb85fe_b155_499b_9e5f_62038c4a47a4
is: P00338
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3939
name: LDHA
constant: false

metaM mthgxl c
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: methylglyoxal
boundary condition: false
is: CHEBI:17158
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
type: Species
initial concentration: 1.0

metaM ksii core4 pre6 g
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: SBO:0000247
is: CHEBI:28067

metaM pmtcrn x
constant: false
initial concentration: 1.0
is: CHEBI:17490
initial amount: NaN
name: L-palmitoylcarnitine
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species

metaR r2132
is: SBO:0000185
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false

metaM chlstol r
initial concentration: 1.0
is: HMDB06842
constant: false
boundary condition: false
has only substance units: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
type: Species
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: CHEBI:16290
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_760e7e1b_9e81_4be8_973e_094a60e067aa
has part: P25705
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
has part: Q6I9V2
is encoded by: hsa:509
type: Species
has only substance units: false
is encoded by: hsa:498
initial amount: NaN

metaM dhea r
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
initial amount: NaN
boundary condition: false
is: HMDB00077
type: Species
name: 3beta-hydroxyandrost-5-en-17-one
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28689

http://identifiers.org/biomodels.db/MODEL1310110035#_7f5454f3_e478_434a_b36d_44c638e53349
constant: false
is encoded by: hsa:50940
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9HCR9
name: PDE11A

metaM prist x
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: pristanic acid
is: CHEBI:51340
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: HMDB00795
initial concentration: 1.0

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
product: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction

metaM glc D c
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial concentration: 1.0
constant: false
is: HMDB00122
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:4167

metaR GMAND
type: Reaction
reactant: MODEL1310110035#
name: GDP-D-mannose dehydratase
is version of: http://identifiers.org/ec-code/4.2.1.47
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_783e2a00_6581_4c25_8f76_006f8ed5d808
has only substance units: false
is encoded by: hsa:127
constant: false
type: Species
is: P08319
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ADH4
initial amount: NaN

metaM biocyt m
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: C05552
type: Species
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
name: Biocytin

metaM dolp U r
name: dolichyl phosphate(2-)
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57683
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
has only substance units: false
initial amount: NaN

metaR GALGLUSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
name: galgluside hs intracellular transport
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
reversible: true

metaR BACCLm
fast: false
modifier: MODEL1310110035#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000254
kinetic law: MODEL1310110035#
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT

metaR CYSt4
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
product: MODEL1310110035#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
fast: false
name: L-cysteine reversible transport via sodium symport
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000304

metaR VLCS2p
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false

metaM 4hpro LT c
is: HMDB00725
is: SBO:0000247
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
type: Species
is: CHEBI:18095
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaR r2131
type: Reaction
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110035#
is: SBO:0000185

metaR GBA
product: MODEL1310110035#
name: Glucosylceramidase
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110035#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#

metaR THMMPtm
name: Thiamine monophosphate transport, mitochondrial
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
fast: false

metaM damp c
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
name: dAMP(2-)
is: HMDB00905
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:58245
initial concentration: 1.0

metaR HPDCACRNCPT2
name: heptadecanoate transport into the mitochondria
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
reversible: false
kinetic law: MODEL1310110035#

metaR r2525
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110035#

metaR FUT17g
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
modifier: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000269
name: Galactoside 2-alpha-L-fucosyltransferase 1
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.69

http://identifiers.org/biomodels.db/MODEL1310110035#_c67af851_44e7_469f_88c6_8343b9f9db50
boundary condition: true
name: CRAT
has only substance units: false
initial amount: NaN
is: P43155
constant: false
is: SBO:0000252
is encoded by: hsa:1384
initial concentration: NaN
type: Species

metaM ps hs m
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: ps_hs[m]
initial concentration: 1.0

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_486d9824_b6c9_43c5_ad53_cf0eeaeffedb
is encoded by: hsa:60482
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9GZV3
constant: false
is: SBO:0000252
type: Species
name: SLC5A7

metaM cmpacna c
is: SBO:0000247
boundary condition: false
is: CHEBI:57812
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01176

http://identifiers.org/biomodels.db/MODEL1310110035#_013cb95d_7d08_4458_9487_aeba0b1908a4
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: NDUFS7
is: O75251
is encoded by: hsa:374291
boundary condition: true

metaR HPDCACRNCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110035#
name: carnitine fatty-acyl transferase
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ

metaR NDPK10n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110035#
reversible: true
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110035#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaR r0191
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.2.1.24
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_fc57004c_dd2d_4d90_9636_3f85a640a7e3
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2686
name: GGT7
has only substance units: false
constant: false
is: A0PJJ9
boundary condition: true
is: SBO:0000252

metaR r0779
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
kinetic law: MODEL1310110035#

metaM phytcoa x
type: Species
has only substance units: false
is: HMDB01359
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: CHEBI:57391
constant: false
initial concentration: 1.0
name: phytanoyl-CoA(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_92e14207_7da5_4c16_a72d_2b7c88c53be1
has only substance units: false
is encoded by: hsa:7084
is: O00142
initial amount: NaN
name: TK2
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_c794754c_c293_4518_be4a_af931c52064d
is encoded by: hsa:64850
is: Q8TBG4
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: AGXT2L1
is: SBO:0000252
boundary condition: true
constant: false

metaR FAOXC226
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110035#
reversible: false

metaR r2526
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_c1885ef6_37bc_4328_959f_c0f3df15bdc4
type: Species
is: P48651
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PTDSS1
is encoded by: hsa:9791
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_7c237af4_c05d_49a1_a21c_5ce5d6dafb62
constant: false
has only substance units: false
initial concentration: NaN
name: PRPS1L1
is encoded by: hsa:221823
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM od2coa c
constant: false
boundary condition: false
has only substance units: false
is: C16218
initial amount: NaN
is: CHEBI:50570
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM gcald c
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
has only substance units: false
is: CHEBI:17071
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: glycolaldehyde
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_db910e57_9e33_4503_a900_d9f9ec063c8b
has only substance units: false
boundary condition: true
type: Species
is: Q9HBF5
is encoded by: hsa:400410
name: ST20
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 25aics c
is: C04823
initial concentration: 1.0
is: HMDB00797
has only substance units: false
is: CHEBI:58443
initial amount: NaN
type: Species
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: SBO:0000247
boundary condition: false
constant: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

http://identifiers.org/biomodels.db/MODEL1310110035#_8eae17e4_f24c_44ff_bf7c_156da9130cd4
has part: B3KUV7
initial concentration: NaN
is encoded by: hsa:51227
is encoded by: hsa:9091
initial amount: NaN
is encoded by: hsa:5279
has part: Q92535
has part: Q14442
has part: Q9BRB3
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: O94777
is: SBO:0000297
is encoded by: hsa:5277
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5283
type: Species

metaR r1832
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110035#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110035#

metaR RE1807M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
name: RE1807
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#

metaR PCHOLPr hs
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
type: Reaction
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_f76eaf57_302b_4bf3_896d_7fa5dda86873
is encoded by: hsa:R51273
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _R51273_1_c

metaR ITCOALm
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: true
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000212
is: SBO:0000176
kinetic law: MODEL1310110035#

metaR CSNATer
is described by: ECO:0000254
kinetic law: MODEL1310110035#
name: carnitine O-acetyltransferase, endolasmic reticulum
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
fast: false
modifier: MODEL1310110035#

metaR r2133
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaM 4hpro LT e
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
type: Species
is: HMDB00725
is: SBO:0000247
constant: false
name: trans-4-hydroxy-L-proline
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a0779353_0276_4ce6_be51_ca5186881df9
name: PIK3R5:PIK3CG
is: SBO:0000297
has part: Q8WYR1
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:23533

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: HMDB01659
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
initial concentration: 1.0
name: Type IIIA glycolipid
is: CHEBI:15347
initial amount: NaN
is: SBO:0000247
type: Species

metaM ksii core2 pre9 g
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
is: SBO:0000247
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110035#_6f621a62_b1a3_4611_b0e5_d3952af4ea84
is encoded by: hsa:4126
is: O00462
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: MANBA
type: Species
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0b479874_165a_40f3_a0e7_7d067f1adf10
initial concentration: NaN
type: Species
is encoded by: hsa:54344
has only substance units: false
name: DPM3:DPM1:DPM2
is encoded by: hsa:8813
is encoded by: hsa:8818
has part: O60762
initial amount: NaN
is: SBO:0000297
has part: O94777
boundary condition: true
has part: Q86TM7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1ba764be_4edc_49f6_9de9_3fa36d9e5fff
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:2645
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110035#_9c1a844d_d2b8_4838_a864_60a3bcf8e2d7
name: PDE1C
has only substance units: false
is encoded by: hsa:5137
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q8NB10

metaR r0365
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
modifier: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction

metaM glc D g
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: HMDB00122
name: D-glucose
initial concentration: 1.0
is: CHEBI:4167
has only substance units: false
type: Species
boundary condition: false

metaR NTD5m
fast: false
reversible: false
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dTMP), mitochondrial
kinetic law: MODEL1310110035#
type: Reaction

metaR MMEm
reversible: true
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000269
name: methylmalonyl-CoA epimerase/racemase
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.1.99.1
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

metaR r2136
reversible: false
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
is: SBO:0000185

metaM melatn c
name: melatonin
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
is: SBO:0000247
is: HMDB01389
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16796
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_cfaaba8f_5753_41e9_96ed_b6cff5628c25
has part: P00709
constant: false
type: Species
initial amount: NaN
name: B4GALT1:LALBA
initial concentration: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:3906
has only substance units: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_a32fcda7_1439_4346_ad1d_cd2ba6e229e3
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI024818
has only substance units: false
initial concentration: NaN
type: Species
name: _AI024818_1_c

metaM 3docopencoa m
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: 3,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
type: Species
initial amount: NaN
has only substance units: false

metaR SRTNt6 2 r
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_0d5e43fc_b369_453e_a480_c75a2774d8e6
initial amount: NaN
is: SBO:0000252
constant: false
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00257
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:16094
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

metaR LAPCOAe
is described by: ECO:0000134
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110035#
name: LAPCOAe

http://identifiers.org/biomodels.db/MODEL1310110035#_83fe075b_aaf6_4f55_b695_9c05472a53f4
is: SBO:0000252
initial amount: NaN
name: AGL
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:178

metaM 3mox4hpac m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB05175
is: CHEBI:28111
constant: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
boundary condition: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
is: CHEBI:61648
initial concentration: 1.0
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
constant: false
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
boundary condition: false
initial amount: NaN

metaR S6TASE14ly
kinetic law: MODEL1310110035#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM m8mpdol L r
type: Species
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:59093
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_5ef653c6_b310_4170_8438_4ecaf2b314ed
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: P09972
boundary condition: true
name: ALDOC
initial concentration: NaN
is encoded by: hsa:230

metaR LCADi D
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304

metaR r2202
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR GALASE9ly
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM ppcoa c
name: Propanoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01275
is: C00100
is: CHEBI:57392
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaM cholp c
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
name: choline phosphate(1-)
is: CHEBI:295975
has only substance units: false
constant: false

metaR SERtN1
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110035#
name: Serine transport (Na, H coupled)
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true

metaM cdp n
type: Species
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
is: HMDB01546
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58069
initial amount: NaN

metaR r0196
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaM dopasf e
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false
is: SBO:0000247
is: HMDB06275
type: Species
name: dopamine 3-O-sulfate
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:37946

metaR DCSPTN1t
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#

metaM ach e
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
name: acetylcholine
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:15355
initial concentration: 1.0
constant: false

metaM ach c
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: HMDB00895
is: CHEBI:15355
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: acetylcholine
is: SBO:0000247
initial concentration: 1.0

metaM ksi deg17 l
name: keratan sulfate I, degradation product 17
constant: false
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
type: Species
is: HMDB00143
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR SPHK21c
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.91
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
type: Reaction
name: sphingosine kinase 2
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

metaR r0355
product: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110035#

metaM ttetddcoa m
initial amount: NaN
constant: false
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02288
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_e4ad8c23_a076_4547_9302_78959091ff1f
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51727
is: SBO:0000252
is: B2R6S5
initial amount: NaN
boundary condition: true
name: CMPK1
type: Species

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:61648
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1

metaR HMBS
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.5.1.61
kinetic law: MODEL1310110035#
is described by: ECO:0000254
type: Reaction
reversible: false
name: hydroxymethylbilane synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
modifier: MODEL1310110035#

metaR CO2tp
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110035#
name: CO2 peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM T antigen g
boundary condition: false
name: T antigen (core 1)
has only substance units: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:22783

metaR UDPGALtg
is: SBO:0000185
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
reversible: true
fast: false

metaR r1147
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR Htr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
fast: false
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_561d1eef_7a13_4cdf_b3ec_20f2d03f911b
constant: false
is: P09669
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1345
boundary condition: true
is: SBO:0000252
name: COX6C

http://identifiers.org/biomodels.db/MODEL1310110035#_b84c39cf_e37c_404a_b65a_cde1fde8d6b8
name: PYGM
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: P11217
is encoded by: hsa:5837
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_028e0f8d_a7ee_4d74_897c_6ce3729abcf7
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6583
name: SLC22A4
is: SBO:0000252
is: Q9H015
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_b0a53a35_c022_469b_ae46_1c4f06b6859a
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC22A1
is encoded by: hsa:6580
is: O15245
initial concentration: NaN

metaR GLNtm
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110035#
name: L-glutamine transport via electroneutral transporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b2d4df11_8d2c_4e7f_a364_9b889580fc1d
constant: false
name: GBA
initial amount: NaN
has only substance units: false
is encoded by: hsa:2629
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_2aa28019_03fe_45ec_88c8_85dc43ff82bc
name: SLC6A6
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6533
initial amount: NaN
has only substance units: false
is: Q9BRI2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_b01313ab_75c2_442b_8a81_16feeb571a47
constant: false
is encoded by: hsa:204
has only substance units: false
name: AK2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM chol r
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
initial concentration: 1.0
is: HMDB00097
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: choline
constant: false
initial amount: NaN

metaR RE3245C
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
name: RE3245

metaR r0027
reversible: true
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110035#

metaM mi13p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 1D-myo-Inositol 1,3-bisphosphate
is: HMDB06234
initial concentration: 1.0
constant: false
is: CHEBI:18225

metaM prostgd2 e
name: prostaglandin D2(1-)
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: CHEBI:57406
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01403
initial amount: NaN

metaR FAOXC16BRx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR r0193
product: MODEL1310110035#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
reversible: true

metaR S3TASE2ly
kinetic law: MODEL1310110035#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_ca9751cb_4d78_4879_bd60_31bb493452a2
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6817
name: SULT1A1
has only substance units: false

metaR r1148
type: Reaction
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM for r
is: C00058
is: SBO:0000247
type: Species
name: Formate
is: HMDB00142
is: CHEBI:15740
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaM cdp m
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01546
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
name: CDP(3-)
type: Species
is: CHEBI:58069
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
is: C00124
is: CHEBI:0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00143
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_712eaef2_245a_4640_875c_04faa13448f8
name: SLC6A14
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11254
is: Q9UN76

http://identifiers.org/biomodels.db/MODEL1310110035#_3d4b64f4_0487_4d88_9217_2d9e6d952262
has only substance units: false
boundary condition: true
is: P06132
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7389
initial concentration: NaN
name: UROD

metaR FAOXC142C122m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM occoa m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
initial amount: NaN
is: C01944
is: CHEBI:57386
is: HMDB01070

metaR FUT16g
fast: false
is described by: ECO:0000269
product: MODEL1310110035#
type: Reaction
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_8493f518_714e_4cd5_847c_504cd8b35de3
initial amount: NaN
is encoded by: hsa:5335
constant: false
boundary condition: true
name: PLCG1
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: P19174

http://identifiers.org/biomodels.db/MODEL1310110035#_cb3ff274_0d5e_4956_82e8_d6b4455b080a
boundary condition: true
initial amount: NaN
is encoded by: hsa:483
is: SBO:0000297
has part: B7Z3U6
initial concentration: NaN
name: ATP1A1:ATP1B3
type: Species
is encoded by: hsa:476
constant: false
has part: P54709
has only substance units: false

metaM ksii core4 deg4 l
is: HMDB00812
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16953
name: keratan sulfate II (core 4-linked), degradation product 4
notes: FORMULA: C66H108N6O48SX CHARGE: -1
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR THRGLNNaEx
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110035#
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
reactant: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#

metaR NAGA2ly
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.49
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
name: N-acetylgalactosaminidase, alpha-

metaR ETHAK
reversible: false
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.82
product: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
name: Ethanolamine kinase
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110035#

metaM ascb L e
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:38290
name: L-ascorbate
boundary condition: false
initial concentration: 1.0
is: HMDB00044
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
type: Species

metaR r0021
reversible: true
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
modifier: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e8b8c2e7_d184_4464_9b45_0b3f21fc66f6
type: Species
initial amount: NaN
is: O95674
has only substance units: false
name: CDS2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8760

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF

metaM pcrn x
name: propionyl-carnitine
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/107738
initial amount: NaN
boundary condition: false
is: HMDB00824
has only substance units: false

metaR VLCS2r
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
is: SBO:0000176
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304
product: MODEL1310110035#

metaM m7masnB r
has only substance units: false
is: C05881
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR PCHOLPg hs
reversible: false
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110035#
name: choline phosphatase

http://identifiers.org/biomodels.db/MODEL1310110035#_6f9e70fb_d602_4c2e_a657_6cdb4877464f
has only substance units: false
constant: false
is: B4DER4
is encoded by: hsa:5291
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PIK3CB
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_5d7b31cf_60f8_4a64_a944_d9541dc83575
is: O14521
boundary condition: true
type: Species
is encoded by: hsa:6392
initial amount: NaN
has only substance units: false
constant: false
name: SDHD
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_61cd0845_b5dc_4efa_ad86_f89857d9de84
is: SBO:0000252
name: ELOVL4
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: Q9GZR5
has only substance units: false
initial amount: NaN
is encoded by: hsa:6785

http://identifiers.org/biomodels.db/MODEL1310110035#_21ee90de_0d06_4371_973f_1c098261ac48
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: P31939
initial concentration: NaN
initial amount: NaN
name: ATIC
is encoded by: hsa:471

metaR r2352
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_2b886307_6f5f_42e7_adab_1d5d231b0ea3
name: GPX5
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: O75715
is: SBO:0000252
is encoded by: hsa:2880
has only substance units: false

metaM prostgd2 c
is: HMDB01403
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
initial concentration: 1.0
name: prostaglandin D2(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_45a148ef_44f7_4b26_b470_f593c3811be9
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: _22305_1_c
boundary condition: true
is encoded by: hsa:22305
constant: false
initial amount: NaN

metaR FAOXTC162TC142m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaM 5pmev c
is: HMDB01343
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1

metaM acald e
has only substance units: false
name: acetaldehyde
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

metaR CYTK14n
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110035#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#

metaR RE3346C
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
name: RE3346
reversible: true
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000

metaR AMANK
is version of: http://identifiers.org/ec-code/5.1.3.14
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: N-acetyl-D-mannosamine kinase
reversible: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#

metaM galside hs l
initial concentration: 1.0
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial amount: NaN
is: CHEBI:12947
is: SBO:0000247
boundary condition: false
has only substance units: false
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
has only substance units: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00304
is: CHEBI:57847
constant: false
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0

metaR NAt5
reversible: true
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
fast: false
name: sodium/ammonium proton antiporter
modifier: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_23096279_ce04_4e07_bc38_120ebcad6fef
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:481
is: A3KLL5
name: ATP1B1

http://identifiers.org/biomodels.db/MODEL1310110035#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
type: Reaction
name: blood group intracellular transport
reversible: true
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110035#

metaR r2353
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
type: Reaction
reversible: true

metaR r0908
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
name: Postulated transport reaction
product: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7aba6876_6322_4750_bea9_fc0d9da3d08b
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI656480
boundary condition: true
has only substance units: false
name: _AI656480_1_m
constant: false
type: Species

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110035#
fast: false
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR r2200
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_2368f5e0_e3fb_4a48_983f_06fd646a93b2
initial amount: NaN
type: Species
boundary condition: true
name: PLA2G4A
has only substance units: false
is encoded by: hsa:5321
initial concentration: NaN
is: P47712
constant: false
is: SBO:0000252

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110035#

metaM saccrp L m
name: L-saccharopinate(1-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57951
initial concentration: 1.0
boundary condition: false
is: HMDB00279
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
constant: false
type: Species

metaR HSD3B11
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone

metaR RE3273C
is described by: ECO:0000000
name: RE3273
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_14c8b701_d6d0_4d17_989a_6ac039e42ba7
is: SBO:0000252
constant: false
is encoded by: hsa:279
is: P04746
has only substance units: false
name: AMY2A
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR SCP22x
name: Sterol carrier protein 2
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110035#
is: SBO:0000185

metaR NODe
reactant: MODEL1310110035#
reversible: true
name: NODe
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000134
fast: false
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR DURItn
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110035#
name: deoxyuridine transport in nucleus
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
type: Reaction

metaM elaid c
is: HMDB00573
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
constant: false
type: Species
name: elaidate
is: CHEBI:30825

http://identifiers.org/biomodels.db/MODEL1310110035#_a9900115_aaee_4b42_afd0_648460ad117e
is encoded by: hsa:5151
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: PDE8A
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR S6T16g
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
reversible: false

metaR FAOXC122C101m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR GALGLUSIDEtg
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
name: galgluside hs intracellular transport
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_593c3ad1_fb7c_407c_9956_21ba4f65249d
type: Species
is: SBO:0000252
is encoded by: hsa:AI761708
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AI761708_1_m
has only substance units: false

metaR r2354
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110035#

metaM acald c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15343
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
initial amount: NaN
name: acetaldehyde
is: HMDB00990
constant: false

metaR r0022
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false

metaR r2201
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000

metaR DOLPMT3 Ler
reactant: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.260
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000000
product: MODEL1310110035#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110035#_231f477c_b7a1_4b80_8e3a_99130210d843
initial amount: NaN
has only substance units: false
is encoded by: hsa:641649
boundary condition: true
name: TMEM91
initial concentration: NaN
is: C9JZ62
is: SBO:0000252
type: Species
constant: false

metaR GGNG
is version of: http://identifiers.org/ec-code/2.4.1.186
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.11
is described by: ECO:0000000
name: glycogenin self-glucosylation
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8908.1) and (2998.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2997.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15238248,PMID:8602861,PMID:9857012 NOTES:NCD
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false

metaM fuc L l
initial amount: NaN
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
name: L-fucose
boundary condition: false
is: CHEBI:18287
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR FAOXC123x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR Htx
reactant: MODEL1310110035#
reversible: true
type: Reaction
fast: false
name: H transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#

metaR FAOXC161C141x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e9a37fad_4eaa_42d0_9d74_ff916ce19a78
constant: false
initial amount: NaN
is: SBO:0000252
is: B4DX94
initial concentration: NaN
has only substance units: false
type: Species
name: PGM3
is encoded by: hsa:5238
boundary condition: true

metaR ILEtec
name: L-isoleucine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110035#_6b99feda_3947_4598_b37b_33c584a4cf2c
is encoded by: hsa:33
constant: false
is: P28330
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ACADL
boundary condition: true

metaR NACHEX19ly
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_907b024f_fd85_46e5_bec1_7b22c1921644
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6535
type: Species
name: SLC6A8
is: B4DIA3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_58a8844b_c52b_4ec0_88c5_3725189b4c4c
is: Q15392
is: SBO:0000252
is encoded by: hsa:1718
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: DHCR24

http://identifiers.org/biomodels.db/MODEL1310110035#_c8c6da41_55de_4a8b_b99f_2cf518fb5b7e
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: A7E2E0
is encoded by: hsa:5293
name: PIK3CD
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r2355
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
product: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110035#

metaM hexc e
constant: false
boundary condition: false
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
initial amount: NaN
has only substance units: false
type: Species
name: cerotate
is: SBO:0000247
is: CHEBI:31013
initial concentration: 1.0
is: HMDB02356

http://identifiers.org/biomodels.db/MODEL1310110035#_179b98b9_3d39_4110_ae30_4fb81019d42f
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6579
is: P46721
is: SBO:0000252
name: SLCO1A2
boundary condition: true
constant: false
initial amount: NaN

metaR ALDD2x
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110035#
fast: false
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110035#

metaR SUCCtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is: SBO:0000185
name: succinate transporter, peroxisome
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_cb375f30_7d6b_49c5_b003_3475c7307bbf
name: SLC38A1
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:81539
is: Q9H2H9
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM lgt S c
is: SBO:0000247
is: HMDB01066
type: Species
is: CHEBI:57474
initial concentration: 1.0
name: (R)-S-lactoylglutathionate(1-)
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
boundary condition: false

metaR HEXCt
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110035#
is: SBO:0000185

metaM hpdcacrn m
is: SBO:0000247
is: HMDB06210
constant: false
has only substance units: false
name: heptadecanoyl carnitine
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3

metaR NDP7g
modifier: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
kinetic law: MODEL1310110035#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reversible: false
fast: false

metaR r2356
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#

metaM galside hs e
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
is: CHEBI:12947
is: SBO:0000247
type: Species
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_29bf2695_f318_4717_a5c1_e1cc3d1b4c7f
has only substance units: false
is encoded by: hsa:9153
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC28A2
is: O43868
type: Species
boundary condition: true

metaR UDPGLCter
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR LEUKTRB4t
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
name: leukotriene B4 transport
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_16c35c62_8b0b_4bc0_bc1a_8a321a671500
is encoded by: hsa:27115
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: PDE7B
is: Q9NP56

metaM elaid e
constant: false
boundary condition: false
name: elaidate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN
has only substance units: false
is: CHEBI:30825
initial concentration: 1.0
is: HMDB00573
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_1cf8582e_dd64_4ff3_bbab_e200c5d8831d
is: SBO:0000252
is encoded by: hsa:205
name: AK4
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: P27144
initial concentration: NaN

metaM dhea c
name: 3beta-hydroxyandrost-5-en-17-one
type: Species
constant: false
is: CHEBI:28689
initial concentration: 1.0
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR HSD3A2r
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM octd11ecoa c
initial concentration: 1.0
constant: false
boundary condition: false
name: 11-octadecenoylcoa
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280771
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_f1bd74fe_74df_44ec_9e42_18ed5e30fcf0
name: HKDC1
is encoded by: hsa:80201
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: B3KT70
type: Species
initial concentration: NaN

metaM ppcoa m
name: Propanoyl-CoA
is: CHEBI:57392
initial concentration: 1.0
has only substance units: false
is: C00100
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01275
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

http://identifiers.org/biomodels.db/MODEL1310110035#_ab4ca530_a79a_4495_b8a2_92e4af23e17b
name: PTEN
is encoded by: hsa:5728
constant: false
is: F6KD01
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM ksi deg16 l
is: SBO:0000247
name: keratan sulfate I, degradation product 16
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16953
is: HMDB00812
has only substance units: false
notes: FORMULA: C160H258N11O137S7 CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110035#_3abdda85_6f37_41d7_8e20_a11e7f32b36c
name: SLC16A10
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:117247
is: SBO:0000252
constant: false
boundary condition: true
is: Q8TF71

metaR r2357
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110035#
type: Reaction

metaR FAOXC161C141m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR PGLer
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
product: MODEL1310110035#
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum
fast: false
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD

metaM 5htrp c
has only substance units: false
name: 5-hydroxy-L-tryptophan
is: HMDB00472
is: SBO:0000247
constant: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17780
initial amount: NaN

metaM cdp e
name: CDP(3-)
type: Species
has only substance units: false
is: HMDB01546
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
is: CHEBI:58069

http://identifiers.org/biomodels.db/MODEL1310110035#_309d9885_288b_4685_9bfc_586bcdb9dd65
initial amount: NaN
is: SBO:0000252
name: ENPP1
has only substance units: false
initial concentration: NaN
constant: false
is: P22413
boundary condition: true
type: Species
is encoded by: hsa:5167

metaR RE2649C
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
name: RE2649
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaM vacc e
initial amount: NaN
has only substance units: false
is: CHEBI:30828
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: trans-vaccenate
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+

http://identifiers.org/biomodels.db/MODEL1310110035#_3ea1bebe_36ed_4933_b57d_11c66feb88ca
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:D29675
name: _D29675_1_e
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_368abd74_b5e0_49f9_b17c_40edca1f0261
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: Q9NQR4
is: SBO:0000252
is encoded by: hsa:56954
initial concentration: NaN
name: NIT2

metaM galside hs g
is: CHEBI:12947
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ebec47c3_ac95_4771_931f_b9689389c2a1
is encoded by: hsa:2517
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: FUCA1
is: P04066
has only substance units: false

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110035#
fast: false
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000

metaR G14T13g
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
reactant: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110035#

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_a8328ddd_8df8_46cf_a823_d565ee565b16
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q6PXP3
is encoded by: hsa:155184
constant: false
name: SLC2A7
initial concentration: NaN
has only substance units: false
type: Species

metaR FAOXC180x
is: SBO:0000176
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) NJ

metaM mal L c
name: (S)-malate(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:15589
initial concentration: 1.0
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR r2359
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
reversible: true

metaM acgam1p c
has only substance units: false
is: SBO:0000247
is: CHEBI:7125
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
type: Species
initial concentration: 1.0
is: HMDB01367
initial amount: NaN
constant: false
name: N-Acetyl-D-glucosamine 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110035#_b6de6a4a_3be4_4682_bad8_95b0ca666255
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7108
type: Species
constant: false
name: TM7SF2
boundary condition: true
has only substance units: false
is: O76062

metaR ASNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is: SBO:0000185

metaR PNP
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase
type: Reaction
reversible: true
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110035#

metaM cdp c
type: Species
constant: false
name: CDP
is: CHEBI:58069
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
has only substance units: false
is: HMDB01546
boundary condition: false
initial amount: NaN
is: C00112

http://identifiers.org/biomodels.db/MODEL1310110035#_2f377e34_3152_4eff_8ffd_7cbcd5ceddb3
boundary condition: true
initial concentration: NaN
constant: false
is: P35218
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:763
name: CA5A

metaM vacc c
initial amount: NaN
boundary condition: false
is: CHEBI:30828
name: trans-vaccenate
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: SBO:0000247
type: Species
constant: false
is: C08367
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
is: SBO:0000247
boundary condition: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: HMDB00143
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
is: CHEBI:12936

metaR RE2814M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110035#
name: RE2814
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_a09603f5_2d1c_468a_a00e_81a889440132
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AU149534
initial amount: NaN
boundary condition: true
name: _AU149534_1_e
has only substance units: false
is: SBO:0000252

metaR 5ADTSTSTERONEte
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110035#
type: Reaction
name: 5 alpha dihydrotesterone transport

metaR r0464
product: MODEL1310110035#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
reversible: true
is: SBO:0000176

metaM ksi deg6 l
initial concentration: 1.0
is: HMDB00143
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 6
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: CHEBI:12936
constant: false

metaR r0086
type: Reaction
reversible: false
modifier: MODEL1310110035#
is described by: ECO:0000000
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.1.3

metaR KHte
reversible: true
name: KHte
is described by: ECO:0000134
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110035#
type: Reaction

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_ffeaf2b4_667a_46c7_a5cf_cc097df85291
name: AGL
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:178

metaR LCTStg
reactant: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000000
name: lactose transport from Golgi to extracellular (via vesicle)
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD

metaM mal L e
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: CHEBI:15589
is: HMDB00156
boundary condition: false
name: (S)-malate(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM ethamp r
is: CHEBI:58190
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
name: O-phosphonatoethanaminium(1-)
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
has only substance units: false
initial concentration: 1.0

metaR FMNAT
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
fast: false
name: FMN adenylyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y

metaR 34DHXMANDACOX NADP
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
fast: false
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
reversible: true
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM chol n
initial concentration: 1.0
boundary condition: false
name: choline
constant: false
is: CHEBI:15354
is: HMDB00097
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_ae8afde5_cdff_4cc1_9f47_e3108bcee451
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: IREB2
initial concentration: NaN
constant: false
is: P48200
is encoded by: hsa:3658

metaM dopasf c
boundary condition: false
is: CHEBI:37946
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
initial amount: NaN
has only substance units: false
name: dopamine 3-O-sulfate
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_00f78c02_4bc3_42be_9715_65a1ffefb66d
name: NDUFS5
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4725
initial amount: NaN
initial concentration: NaN
is: Q6IBA0
is: SBO:0000252
constant: false

metaR LTC4CP
reactant: MODEL1310110035#
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ

metaR r0085
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3f81e642_7f20_4365_a542_34bfefaeeabf
constant: false
type: Species
boundary condition: true
name: SDHB
is encoded by: hsa:6390
is: P21912
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM galside hs c
boundary condition: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
constant: false

metaM chol m
name: choline
is: SBO:0000247
initial amount: NaN
is: CHEBI:15354
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
initial concentration: 1.0
is: HMDB00097
has only substance units: false
boundary condition: false

metaR KSII CORE4t
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaR LEUATB0tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Leucine into the intestinal cells by ATB0 transporter
type: Reaction

metaM HC01399 x
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:27466

metaR GLCNACT L
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
fast: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR ALDD2y
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r0084
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM fuc L c
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: L-fucose
is: HMDB00174

http://identifiers.org/biomodels.db/MODEL1310110035#_e3874de4_fb92_4588_8604_979e83f81484
is encoded by: hsa:2687
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: P36269
name: GGT5
boundary condition: true
initial amount: NaN

metaM ksi pre23 g
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
constant: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
has only substance units: false

metaM dopa e
initial concentration: 1.0
is: CHEBI:59905
constant: false
is: HMDB00073
boundary condition: false
is: SBO:0000247
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
initial amount: NaN
has only substance units: false

metaM hs deg19 l
boundary condition: false
constant: false
is: HMDB06210
name: heparan sulfate, degradation product 19
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_d4375dc8_344f_435c_a41b_015ffa333d42
initial amount: NaN
has part: P36542
is encoded by: hsa:513
is encoded by: hsa:498
has part: A8K092
has only substance units: false
is encoded by: hsa:509
type: Species
has part: P56381
has part: P30049
is encoded by: hsa:506
initial concentration: NaN
is encoded by: hsa:514
has part: P06576
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
is: SBO:0000297
boundary condition: true

metaR RE2269E
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
is: SBO:0000176
name: RE2269
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.4.21.39
reactant: MODEL1310110035#
type: Reaction

metaR FACOAL80i
product: MODEL1310110035#
name: fatty-acid--CoA ligase (octanoate)
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_915b4536_af61_4ae2_b3eb_910df3a51f94
boundary condition: true
is: Q9H6Y6
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: MYO5B
constant: false
initial concentration: NaN
is encoded by: hsa:4645

metaM peamn c
name: 2-phenylethanaminium
type: Species
constant: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:225237
initial amount: NaN
is: HMDB12275
initial concentration: 1.0

metaR CHSTEROLt1
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is described by: ECO:0000304
name: cholesterol intracellular transport
modifier: MODEL1310110035#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false

metaM gln L m
is: CHEBI:18050
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00641
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_b197d1d2_72be_4f4a_b57a_ff54594dbaf8
name: SLCO3A1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:28232
initial concentration: NaN
is: Q9UIG8

metaM acetone c
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
is: HMDB01659
is: CHEBI:15347
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: acetone
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_da3a190d_45e2_44e2_933b_6750c665692a
is: P47895
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ALDH1A3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:220

metaR DOCO13EFATP
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM hxan e
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17368
name: hypoxanthine
is: SBO:0000247
is: HMDB00157
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262

metaR CRNCAR3tp
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
name: carnitine-propcarnitine carrier, peroxisomal
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_8afc72c9_7d06_40e6_91dd_3cdccb2f898a
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54981
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: Q9NWW6
name: NMRK1
is: SBO:0000252

metaM ksii core2 deg9 l
name: keratan sulfate II (core 2-linked), degradation product 9
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00143
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
type: Species
notes: FORMULA: C30H50N3O20X CHARGE: 0
constant: false

metaR CYTK1m
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_c4d3c9fa_8895_4a1d_af05_6dafca1a30c1
name: UPB1
is encoded by: hsa:51733
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: B3KNC1
boundary condition: true
has only substance units: false
initial amount: NaN

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
name: cholesterol intracellular transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_d21f7985_d1ec_4bbe_9dc4_492c710f047d
initial concentration: NaN
has only substance units: false
name: AOC2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O75106
is encoded by: hsa:314
constant: false

metaR r0899
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_6785adbf_499c_42c8_aee0_8d0ecaa988e2
is: P31639
has only substance units: false
initial amount: NaN
is encoded by: hsa:6524
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC5A2

metaR P45027A11m
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_92dd4fdc_63a6_4b7f_b931_206cd2a7d0be
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q11203
is encoded by: hsa:6487
name: ST3GAL3
type: Species
has only substance units: false
constant: false

metaR S6T3g
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.8.2.21
reversible: false
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_f6dad544_1ce1_427a_8dd1_4c9257fb4408
is: SBO:0000252
name: CYBRD1
initial concentration: NaN
is: B4DWD7
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:79901

metaR r0483
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000000

metaM 2docopencoa m
has only substance units: false
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaM ksii core2 deg6 l
is: SBO:0000247
is: HMDB00143
constant: false
is: CHEBI:12936
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C44H72N4O33SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN
has only substance units: false

metaM o2s e
type: Species
constant: false
boundary condition: false
has only substance units: false
name: superoxide
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
is: HMDB02168

metaM ksi deg31 l
type: Species
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
name: keratan sulfate I, degradation product 31
is: CHEBI:16953
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00812
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_db8372f0_e693_491f_bc44_c9b7a1c6aa31
is encoded by: hsa:10559
is: P78382
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC35A1
boundary condition: true
has only substance units: false

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR FAOXC141C121m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaM rbt c
is: HMDB00508
name: D-ribitol
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15963
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d044ea36_c4f2_4f93_9f05_7ff5a1a56f8e
is: Q14916
type: Species
name: SLC17A1
has only substance units: false
is encoded by: hsa:6568
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_62d22409_0904_4297_8494_6c1d4b1ff257
initial amount: NaN
is: SBO:0000252
type: Species
is: Q13733
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: ATP1A4
is encoded by: hsa:480

metaR CHSTEROLt3
reversible: true
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
name: cholesterol intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0480
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true

metaR PHEMEtm
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110035#
name: Heme transport to cytosol
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR FAOXC181C161m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_fcd433c2_a113_4bf7_9d35_4f57689e7322
is: SBO:0000252
name: GMPR
boundary condition: true
is: P36959
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:2766
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_03bb299a_f2f8_4776_9367_c3df6bceb4d5
has only substance units: false
is encoded by: hsa:6582
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC22A2
constant: false

metaR FBA2
is described by: ECO:0000304
kinetic law: MODEL1310110035#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD

metaM retinal cis 9 c
is: CHEBI:17898
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
is: HMDB01358
type: Species
is: SBO:0000247

metaR r0784
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
reactant: MODEL1310110035#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reversible: true

metaM hxan c
is: CHEBI:17368
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: HMDB00157
is: C00262
boundary condition: false
name: Hypoxanthine
constant: false
type: Species

metaR ALAR
modifier: MODEL1310110035#
type: Reaction
fast: false
name: alanine racemase
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110035#_df898c02_8124_4803_b3e1_d100b896ec8e
initial amount: NaN
has only substance units: false
name: BCKDHB
constant: false
type: Species
is: P21953
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:594

metaM itp c
initial concentration: 1.0
is: CHEBI:57614
is: HMDB00189
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2129
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_f74e2cd5_184b_4904_a29f_39b5c8b01148
initial concentration: NaN
type: Species
initial amount: NaN
is: P11310
is: SBO:0000252
name: ACADM
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110035#_7d5bd5ee_c04e_4261_a6bb_6c4f27f72640
boundary condition: true
is: B7Z6S1
initial concentration: NaN
name: GBA
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2629
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6b337b85_cbf9_4f68_957e_bf460d82991d
boundary condition: true
is encoded by: hsa:30833
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: NT5C
is: SBO:0000252
is: Q8TCD5

metaR C4STMO2Pr
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-4 methyl sterol oxidase
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

metaM glygn1 c
initial amount: NaN
is: CHEBI:17115
name: glycogen, structure 1 (glycogenin-11[1,4-Glc])
is: HMDB00187
initial concentration: 1.0
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02133
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fe96aebf_a206_4fab_9c54_011cecc4cdfb
is: SBO:0000252
is: Q53Y41
initial concentration: NaN
is encoded by: hsa:1644
constant: false
initial amount: NaN
name: DDC
has only substance units: false
type: Species
boundary condition: true

metaR r2128
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#

metaR r0781
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110035#
reversible: true

metaR r2519
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
type: Reaction
fast: false
name: Utilized transport
product: MODEL1310110035#
is described by: ECO:0000000

metaR BTNDe
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
name: biotinidase (biotin), extracellular
reactant: MODEL1310110035#

metaR L LACt2r
reversible: true
modifier: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110035#
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
fast: false
type: Reaction

metaR GLCtg
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reversible: true
is described by: ECO:0000269
type: Reaction
name: glucose transport, Golgi apparatus
kinetic law: MODEL1310110035#

metaM dnad c
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00857
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: HMDB01179
boundary condition: false
is: CHEBI:18304
constant: false
name: Deamino-NAD+
has only substance units: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM CE2433 m
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57795
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_edf9043e_50fb_466e_b156_acf8c7647f2c
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: Q8TE04
type: Species
name: PANK1
is: SBO:0000252
is encoded by: hsa:53354

http://identifiers.org/biomodels.db/MODEL1310110035#_4b9412e5_5c8e_4445_99a6_44c69b032142
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:6120
name: RPE
initial concentration: NaN
is: SBO:0000252
is: Q53TV9
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_977f85de_2526_49da_9d6a_7e1b8fdaed7c
name: LHPP
type: Species
is encoded by: hsa:64077
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9H008

metaR CHOLATEt
is: SBO:0000185
reversible: true
name: cholate transport via bicarbonate countertransport
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269

metaR FAOXC14C12m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR RE1530M
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
name: RE1530
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21

metaM din c
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00071
name: Deoxyinosine
is: CHEBI:28997
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247

metaM 4ppcys c
boundary condition: false
initial concentration: 1.0
is: CHEBI:59458
is: C04352
type: Species
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
initial amount: NaN
is: SBO:0000247

metaM rbt e
boundary condition: false
initial amount: NaN
name: D-ribitol
is: CHEBI:15963
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
is: HMDB00508

http://identifiers.org/biomodels.db/MODEL1310110035#_f9222788_446e_4511_acf3_20aeab2f376e
is: B3KTQ4
is encoded by: hsa:8706
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: B3GALNT1
is: SBO:0000252

metaM itp e
is: CHEBI:57614
is: HMDB00189
initial concentration: 1.0
type: Species
boundary condition: false
name: ITP(3-)
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247

metaM pro L m
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17203
is: SBO:0000247
name: L-proline
boundary condition: false

metaR r0782
kinetic law: MODEL1310110035#
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false

metaR FBA4
is: SBO:0000176
type: Reaction
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM oaa m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB00223
is: C00036
name: Oxaloacetate
initial concentration: 1.0
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

http://identifiers.org/biomodels.db/MODEL1310110035#_899ec552_1f29_4d8e_ae31_0a21a98dfaab
initial concentration: NaN
is: O00476
is encoded by: hsa:10786
name: SLC17A3
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR PAFHe
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.47
kinetic law: MODEL1310110035#
name: Platelet-activating factor acetylhydrolase

http://identifiers.org/biomodels.db/MODEL1310110035#_f1c02527_a6fc_48f3_8c13_b2729152eb6b
type: Species
is: SBO:0000297
initial amount: NaN
boundary condition: true
has part: P53597
constant: false
has only substance units: false
is encoded by: hsa:8801
initial concentration: NaN
name: SUCLG2:SUCLG1
is encoded by: hsa:8802
has part: Q96I99

http://identifiers.org/biomodels.db/MODEL1310110035#_bdf0174a_121e_4083_acc1_8d26dce520f2
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: B3GNT1
boundary condition: true
is: O43505
is encoded by: hsa:11041

metaR GBSIDEte
name: globoside transport
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_7e2a96a7_dbbb_47c5_a6f6_b2d4f508497c
boundary condition: true
is: Q92959
has only substance units: false
is encoded by: hsa:6578
constant: false
type: Species
is: SBO:0000252
name: SLCO2A1
initial concentration: NaN
initial amount: NaN

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00158
has only substance units: false
is: CHEBI:17895
name: L-tyrosine
initial concentration: 1.0
constant: false

metaR r2127
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110035#

metaM dopa c
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:59905
type: Species
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
name: dopaminium(1+)
initial concentration: 1.0
initial amount: NaN

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR ABTArm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_a028008a_6b59_4b13_87b5_a8003a1cdc59
is encoded by: hsa:23539
has only substance units: false
initial concentration: NaN
name: SLC16A8
constant: false
is: SBO:0000252
is: O95907
type: Species
boundary condition: true
initial amount: NaN

metaM hexccoa c
type: Species
initial amount: NaN
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: SBO:0000247
is: HMDB06459
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
constant: false

metaM ksi pre32 g
initial amount: NaN
boundary condition: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 32
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067

metaM ahdt e
type: Species
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00980
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
is: CHEBI:58462
initial amount: NaN
name: 7,8-dihydroneopterin 3'-triphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110035#_9dabbb43_75fc_4148_81eb_f027c7403d11
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2530
name: FUT8
initial amount: NaN
constant: false
is: Q9BYC5
type: Species
is: SBO:0000252

metaM nrpphr c
boundary condition: false
initial concentration: 1.0
name: Norepinephrine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false
has only substance units: false
type: Species
is: CHEBI:33569
is: HMDB00216

metaR r2126
modifier: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM q10h2 c
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB13111
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10

metaR 3MOPt2im
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
is described by: ECO:0000000
reversible: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false

metaR FAOXC183C163Gm
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_a412f726_f1da_4db4_8673_ced669002d13
initial amount: NaN
is encoded by: hsa:3417
is: SBO:0000252
name: IDH1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: O75874
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_e3283528_aa1e_4ac6_be56_88733b10a96d
is encoded by: hsa:1583
name: CYP11A1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: G3XAD7

metaR BAAT3x
is described by: ECO:0000304
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110035#

metaR 3AIBtm
name: 3-amino-isobutyrate transport, mitochondrial
reactant: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
is: SBO:0000185

metaR r0780
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
type: Reaction

metaR NACHEXA22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_504762b3_eecb_4efa_a95b_060af8990722
is: Q16739
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:7357
name: UGCG

metaR PI45PLC
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#

metaR r1711
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110035#
fast: false
is: SBO:0000185
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9db844af_159d_414a_8190_9f611d8dcb66
boundary condition: true
type: Species
is: Q96CA6
constant: false
has only substance units: false
is encoded by: hsa:30
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ACAA1

metaR FAOXC226C205m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR MCCCrm
type: Reaction
is: SBO:0000176
fast: false
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/6.4.1.4
modifier: MODEL1310110035#
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110035#

metaR THRGLYexR
reversible: true
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110035#
is: SBO:0000185
name: L-threonine/glycine reversible exchange

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaR S3TASE1ly
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reactant: MODEL1310110035#
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR r2012
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM HC01403 x
initial concentration: 1.0
type: Species
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM nrpphr e
constant: false
is: CHEBI:33569
initial concentration: 1.0
name: Norepinephrine
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
is: SBO:0000247
is: HMDB00216
has only substance units: false
type: Species

metaR r2124
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110035#
is: SBO:0000185

metaM q10h2 e
name: Ubiquinol-10
is: HMDB13111
constant: false
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
boundary condition: false

metaR AKR1D2
type: Reaction
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is described by: ECO:0000269
is: SBO:0000176
reversible: false

metaR CYTDt
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
name: cytidine facilated transport in cytosol
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110035#

metaR r1574
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction

metaR FAOXC205C184x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_5c6c5478_fbdb_480c_b401_a63723b2a134
has only substance units: false
name: SLC33A1
is encoded by: hsa:9197
constant: false
is: SBO:0000252
is: O00400
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaR PROt2r
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000304
fast: false
name: L-proline reversible transport via proton symport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction

metaM gdpmann c
name: GDP-alpha-D-mannose(2-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB01163
type: Species
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_8c756243_e9ca_43b6_8c73_4ae541ed4055
boundary condition: true
initial concentration: NaN
constant: false
name: CDIPT
is encoded by: hsa:10423
is: A8K3L7
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_871686b3_d03a_4f70_8f34_32777eeb221d
has only substance units: false
is encoded by: hsa:3706
initial amount: NaN
is: P23677
name: ITPKA
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR GALASE20ly
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110035#_66a02d25_fc62_4bf2_a331_46e65ec7407d
name: ABAT
boundary condition: true
initial amount: NaN
is encoded by: hsa:18
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

metaR r2123
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false

metaM HC02206 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57399
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)

metaR r1573
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_fbf8780b_28a1_4058_a750_94975acbf401
initial amount: NaN
name: _R14373_1_x
has only substance units: false
boundary condition: true
is encoded by: hsa:R14373
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_a584da10_0253_4819_9cbb_088b07e617db
name: ACAA1
is encoded by: hsa:30
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: Q96CA6

metaM ksii core4 pre3 g
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 3
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB00175
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247
is: C00130

metaR r0330
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is: SBO:0000176
reversible: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
kinetic law: MODEL1310110035#

metaR GCALDD
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Glycolaldehyde dehydrogenase
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110035#_bfbeb202_4f09_4f99_8c6b_383e12045560
initial amount: NaN
is: Q9BVG9
has only substance units: false
name: PTDSS2
is encoded by: hsa:81490
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaM HC02187 e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28774
boundary condition: false
name: reverse-triiodthyronine
constant: false
type: Species
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: SBO:0000247

metaR r2018
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110035#

metaR MGCHrm
is: SBO:0000176
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
reversible: true
fast: false

metaM doldp L r
name: Dolichol diphosphate, human liver homolog
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15750
has only substance units: false
type: Species
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
boundary condition: false
constant: false
is: SBO:0000247

metaR r2017
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_9042d25d_54c4_47f4_b90f_7ffa6aee8d45
boundary condition: true
name: BTD
type: Species
is: P43251
has only substance units: false
initial amount: NaN
is encoded by: hsa:686
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r2122
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1576
is: SBO:0000185
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110035#_f1f19bc3_9dc1_4963_9e9d_264b50a66bc8
has only substance units: false
is encoded by: hsa:113452
is: SBO:0000252
is: Q969K7
boundary condition: true
initial amount: NaN
name: TMEM54
initial concentration: NaN
constant: false
type: Species

metaM o2s m
boundary condition: false
is: C00704
is: CHEBI:18421
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
constant: false
type: Species
has only substance units: false

metaR CSNATr
reversible: true
type: Reaction
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_c29c5256_6835_4047_a813_51680d6e8377
has only substance units: false
initial concentration: NaN
name: FOLR1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:2348

metaM thmmp c
initial concentration: 1.0
name: Thiamin monophosphate
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial amount: NaN
has only substance units: false
is: CHEBI:37575
is: SBO:0000247
type: Species
is: C01081
is: HMDB02666
constant: false
boundary condition: false

metaR EX xoltri24 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7-alpha,24(S)-Dihydroxycholesterol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_d54a161b_8fe4_4070_ba65_160c76d41d4a
initial amount: NaN
has only substance units: false
is encoded by: hsa:23556
type: Species
name: PIGN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fc7bdde6_24df_4ec2_8faa_5d196437a76c
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:54
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ACP5
is: P13686

metaM ksi deg20 l
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 20
boundary condition: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110035#_237a0397_c24c_4e24_acea_8d75d4adb06e
is encoded by: hsa:6484
constant: false
initial amount: NaN
boundary condition: true
name: ST3GAL4
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q6IBE6

metaM tyr L e
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
name: L-tyrosine
has only substance units: false
is: HMDB00158
is: CHEBI:17895
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR PE HSter
name: phosphatidylethanolamine scramblase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185

metaR r2121
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110035#_75a9a312_ce74_451e_b620_c782ef777e5e
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: O00767
has only substance units: false
name: SCD
constant: false
is: SBO:0000252
is encoded by: hsa:6319

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ethamp c
is: SBO:0000247
is: CHEBI:58190
initial amount: NaN
type: Species
name: ethamp[c]
is: HMDB00224
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346

http://identifiers.org/biomodels.db/MODEL1310110035#_88b16e80_3da7_4909_ac21_88c8b5676dad
name: SMPD3
is: Q9NY59
constant: false
is encoded by: hsa:55512
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM HC02187 c
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0
is: CHEBI:28774
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: reverse-triiodthyronine

http://identifiers.org/biomodels.db/MODEL1310110035#_732356c3_371c_48cd_b015_2ccb8510923f
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5330
boundary condition: true
name: PLCB2
has only substance units: false
is: Q59F77

metaR r2514
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110035#
name: Utilized transport
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM glyc3p c
is: CHEBI:57597
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
has only substance units: false
is: C00093
initial concentration: 1.0
name: Glycerol 3-phosphate

http://identifiers.org/biomodels.db/MODEL1310110035#_132eb5ca_5933_4315_a3fb_183872b6cbae
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: NDUFC1
is: O43677
has only substance units: false
is encoded by: hsa:4717
boundary condition: true

metaR RE3520E
name: RE3520
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
fast: false
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is described by: ECO:0000000

metaR r1570
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaM glu L c
type: Species
is: CHEBI:29985
is: HMDB00148
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
boundary condition: false
initial amount: NaN
name: L-glutamate(1-)
initial concentration: 1.0

metaR NACHEX13ly
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110035#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110035#_a7c8ccf6_f3b5_42b7_afa0_c9fe2e31969c
name: SLC46A1
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:113235
boundary condition: true
is: Q96NT5
constant: false
type: Species
initial concentration: NaN

metaR r0789
reversible: true
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
modifier: MODEL1310110035#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR r2120
reactant: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110035#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000

metaR r2511
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Utilized transport
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_0c819fde_b71c_4c38_8e1b_5956d6978be2
initial amount: NaN
is encoded by: hsa:2098
is: P10768
initial concentration: NaN
name: ESD
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaM CE2418 m
boundary condition: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110035#_c30b05ba_4140_4b68_915a_32f3f12dcd3e
boundary condition: true
type: Species
name: _AI620219_1_e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI620219
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_27c7ac88_b1cf_42d6_b556_499514d3a188
has only substance units: false
is: O00459
is encoded by: hsa:5296
type: Species
constant: false
is: SBO:0000252
name: PIK3R2
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_4f82726f_e43b_4cfa_9125_4b3b20100ac4
is encoded by: hsa:509
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ATP5C1
is: P36542
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_8050ac4e_2a05_459a_90aa_a8fb3e4b2e2d
name: HSD3B1
boundary condition: true
initial amount: NaN
is encoded by: hsa:3283
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: P14060
has only substance units: false

metaR DESAT20 1
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
reversible: false
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_de788263_189d_4c7e_ae2a_59ee73051fb7
constant: false
initial amount: NaN
type: Species
is: P14060
boundary condition: true
name: HSD3B1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3283

metaR BTNDm
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110035#
is described by: ECO:0000269
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
name: biotinidase (biotin), mitochondrial

metaR GTHDH
type: Reaction
is described by: ECO:0000134
product: MODEL1310110035#
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
fast: false
reversible: false

metaM HC02217 c
has only substance units: false
is: CHEBI:27647
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: prostaglandin-g2

metaR XYLK
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.17
notes: GENE_ASSOCIATION: (9942.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
name: xylulokinase
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
fast: false

metaM itp n
boundary condition: false
name: ITP(3-)
type: Species
is: SBO:0000247
is: CHEBI:57614
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaR PROSTGE1t
reversible: true
product: MODEL1310110035#
is: SBO:0000185
fast: false
name: prostaglandin transport via bicarbonate countertransport
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM ascb L c
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: L-ascorbate
type: Species
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
is: SBO:0000247
is: HMDB00044

http://identifiers.org/biomodels.db/MODEL1310110035#_1406aaba_316d_4ad8_a69b_8497876f3247
type: Species
constant: false
is encoded by: hsa:80724
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACAD10
is: SBO:0000252
has only substance units: false
is: G3XAJ0

metaR ARABR
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
reversible: false
name: arabinose reductase
product: MODEL1310110035#
reactant: MODEL1310110035#

metaR SUCCt2m
fast: false
reversible: true
is: SBO:0000185
name: succinate transport, mitochondrial
modifier: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR DESAT20 2
reversible: false
is: SBO:0000176
fast: false
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction

metaM dolmanp U r
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15809
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_4f07f442_22e5_4482_a0fd_dbef367287e9
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5286
is: O00443
name: PIK3C2A

metaR LPS3e
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: lipase, extracellular
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000

metaM hs deg15 l
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:16126
boundary condition: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
is: SBO:0000247
name: heparan sulfate, degradation product 15

http://identifiers.org/biomodels.db/MODEL1310110035#_52dcf20b_7800_4a21_a0a6_9e9785884ea1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: AMPD3
is: SBO:0000252
is: B7Z763
is encoded by: hsa:272
constant: false

metaM acetone e
has only substance units: false
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: CHEBI:15347
name: acetone
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01659

http://identifiers.org/biomodels.db/MODEL1310110035#_291c9bc1_88f6_4904_bd28_c403343ed6bf
initial concentration: NaN
is encoded by: hsa:79717
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9HAB8
is: SBO:0000252
name: PPCS

http://identifiers.org/biomodels.db/MODEL1310110035#_7e6306eb_20f1_431f_a861_34ff05c5bfc3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:51166
type: Species
name: AADAT
is: Q4W5N8

metaM glu L e
name: L-glutamate(1-)
type: Species
is: HMDB00148
is: CHEBI:29985
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_ffa6c17f_fe34_4cd1_9272_728c9ea796c9
is encoded by: hsa:477
constant: false
is encoded by: hsa:23439
has only substance units: false
has part: Q9UN42
initial concentration: NaN
has part: P50993
is: SBO:0000297
boundary condition: true
type: Species
initial amount: NaN
name: ATP1B4:ATP1A2

metaR ABO4g
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.37
reactant: MODEL1310110035#
is described by: ECO:0000269
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176

metaM dolglcp L r
initial amount: NaN
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
is: CHEBI:15812
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0787
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR r0892
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.2.27
is: SBO:0000185
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_1ffea121_4972_43e3_8bb8_88c20daec415
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:441024
name: MTHFD2L
is: SBO:0000252
initial amount: NaN
is: Q9H903
type: Species

metaM HC01842 c
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
constant: false
is: SBO:0000247
boundary condition: false
name: Phosphodimethylethanolamine
type: Species
is: CHEBI:31997
initial concentration: 1.0
has only substance units: false

metaR RE1530C
name: RE1530
type: Reaction
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_45492a77_2188_43c9_bdfd_2377838b4d0f
name: PYCR1
initial concentration: NaN
is: A6NFM2
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5831
type: Species
has only substance units: false
initial amount: NaN

metaR CERT2rt
is: SBO:0000185
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110035#
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_bc3ffcb2_e30d_424a_9665_3c00f1da82ed
type: Species
initial concentration: NaN
initial amount: NaN
is: Q02218
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4967
has only substance units: false
name: OGDH

metaM pppg9 m
type: Species
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
constant: false
is: CHEBI:57307
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01097
initial amount: NaN
is: SBO:0000247
name: Protoporphyrinogen IX
is: C01079

metaM HC02217 e
type: Species
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaR DM dgpi prot hs r
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR PETHCT
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
name: phosphoethanolamine cytidyltransferase
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.7.14

metaR r1571
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

metaR DGCHOLte
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false
name: bile acid intracellular transport
reversible: true

metaR r0788
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM HC02206 e
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57399
constant: false
name: prostaglandin C1(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_1610bf1a_0849_44e4_94dc_a9045d147e2c
boundary condition: true
initial amount: NaN
has part: A3KLL5
constant: false
has only substance units: false
is encoded by: hsa:478
name: ATP1A3:ATP1B1
initial concentration: NaN
is encoded by: hsa:481
type: Species
has part: B7Z2T0
is: SBO:0000297

metaM cdpea c
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57876
is: HMDB01564
name: cdpea[c]
has only substance units: false

metaR GAL3ST11
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is: SBO:0000176
name: Galactosylceramide sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110035#

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:57817
name: sphinganine(1+)
is: HMDB00269
initial concentration: 1.0
boundary condition: false

metaM leuleu e
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_27df001a_ca65_48aa_a43c_512283b99d59
name: NAGK
is: Q9UJ70
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55577
constant: false

metaM 4ppcys m
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: HMDB01117
has only substance units: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:59458
type: Species
is: SBO:0000247

metaR TKT1
kinetic law: MODEL1310110035#
reversible: true
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110035#_133021f2_9847_4bae_89c0_201c5d421edb
is: SBO:0000252
is encoded by: hsa:8612
constant: false
boundary condition: true
is: E9PAY8
name: PPAP2C
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
initial amount: NaN
is: C03740
constant: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 5-L-Glutamyl-L-alanine
boundary condition: false
has only substance units: false
is: HMDB06248

metaR r1569
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
fast: false
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#

metaR KYNAKGAT
fast: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB

metaM ggn c
is: SBO:0000247
name: primed glycogenin (glycogenin-8[1,4-Glc])
notes: FORMULA: C48H81O41X CHARGE: 0 INCHI: InChI=1/C6H11O5/c7-1-4-6(10)5(9)3(8)2-11-4/h2-10H,1H2/t3-,4+,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC02131
initial amount: NaN
boundary condition: false
is: CHEBI:57606
constant: false
is: HMDB00267
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a60965de_ed78_4c9d_b16a_1d433796eb41
boundary condition: true
is encoded by: hsa:178
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: AGL
is: SBO:0000252
initial concentration: NaN

metaM leuleu c
boundary condition: false
has only substance units: false
type: Species
constant: false
name: Leucylleucine
is: http://identifiers.org/pubchem.compound/94244
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: SBO:0000247

metaR r2341
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185

metaM zym int2 r
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: zymosterol intermediate 2
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
is: SBO:0000247
is: CHEBI:52386
initial amount: NaN

metaR r2520
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
product: MODEL1310110035#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_5845df25_b2de_4e93_9c7a_c2a724eb28d0
is encoded by: hsa:10965
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P49753
boundary condition: true
name: ACOT2
constant: false
initial concentration: NaN

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
is: CHEBI:27668
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaM pail5p hs c
initial concentration: 1.0
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110035#_b4ba91d5_fafa_494d_86c0_1981d85b5b35
boundary condition: true
is encoded by: hsa:54576
type: Species
name: UGT1A8
constant: false
is: Q5DSZ6
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110035#
name: aldose reductase (methylglyoxal)
reversible: false
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
type: Reaction

metaM ksi deg9 l
type: Species
has only substance units: false
constant: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
name: keratan sulfate I, degradation product 9
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_c3e09a84_43c1_4934_96ca_06412e36e351
is: Q9UMR5
boundary condition: true
is encoded by: hsa:9374
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: PPT2
initial concentration: NaN
has only substance units: false

metaR TKT2
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: true
name: transketolase
modifier: MODEL1310110035#
fast: false

metaR ABTti
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110035#
fast: false
reversible: false

metaR S6TASE13ly
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM pmtcrn c
constant: false
is: HMDB00222
initial amount: NaN
initial concentration: 1.0
name: L-palmitoylcarnitine
has only substance units: false
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
is: SBO:0000247
boundary condition: false

metaM q10h2 m
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: Ubiquinol-10
type: Species
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaR ALR3
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269

metaM apoC Lys m
is: HMDB00182
initial concentration: 1.0
is: SBO:0000247
name: Apocarboxylase (Lys residue)
type: Species
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM pro L c
has only substance units: false
constant: false
boundary condition: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: HMDB00162
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR ACt2r
name: acetate reversible transport via proton symport
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
fast: false
reversible: true

metaR LCAT1e
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.43
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
reversible: false
name: Lecithin-cholesterol acyltransferase
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0e7beb76_8872_4268_a36c_201c18489c78
is encoded by: hsa:AF116616
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AF116616_1_m
boundary condition: true
initial amount: NaN

metaR FAOXTC101TC102m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR ETFQO
fast: false
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.5.1
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
reactant: MODEL1310110035#

metaR O2tp
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
name: O2 transport, peroxisomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110035#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_c6c2a538_807f_4d09_8fbe_8c9196a90a4e
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6342
name: SCP2
initial concentration: NaN
is: C9JC79
boundary condition: true

metaM oaa c
is: HMDB00223
type: Species
is: C00036
name: Oxaloacetate
boundary condition: false
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR HDCAtr
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion

metaR EX progly LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for prolyl-glycine
type: Reaction

metaM udpacgal c
is: SBO:0000247
boundary condition: false
is: HMDB00304
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN

metaM glc D r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:4167
name: D-glucose
is: HMDB00122
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
has only substance units: false

metaR XOLDIOLONEt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185

metaR HEX1
reactant: MODEL1310110035#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110035#
name: hexokinase (D-glucose:ATP)
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM nm2masn g
is: SBO:0000247
type: Species
initial amount: NaN
is: C05884
notes: FORMULA: C42H70N3O30X CHARGE: 0
initial concentration: 1.0
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
has only substance units: false

metaR FACOAL224
fast: false
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110035#
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110035#_48062925_7d31_4ef0_83e7_09a5c1e0606b
is: SBO:0000252
name: RDH16
type: Species
constant: false
is encoded by: hsa:8608
is: O75452
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_85ef8fd4_15ea_4b92_8031_ad607d53b35c
is: SBO:0000252
constant: false
is: P06576
name: ATP5B
initial amount: NaN
is encoded by: hsa:506
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaR EX doco13ac
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7c33fa2c_ca9c_4c2f_9a75_6adaf145beb7
name: PIK3R1
has only substance units: false
is: E7EX19
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5295
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_90aec8d3_290c_442c_8739_5a8bf98df2d8
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P15328

http://identifiers.org/biomodels.db/MODEL1310110035#_a40c070b_5adc_4538_94c6_bbb23af91252
initial concentration: NaN
is: Q9HAS3
is encoded by: hsa:64078
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
name: SLC28A3

metaR r1565
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#

metaM tag hs c
has only substance units: false
constant: false
is: CHEBI:17855
is: SBO:0000247
initial concentration: 1.0
name: triglyceride
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
type: Species

metaM 5oxpro c
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
is: HMDB00267
initial concentration: 1.0
name: 5-oxoprolinate
is: CHEBI:57606

http://identifiers.org/biomodels.db/MODEL1310110035#_3e4aeb8d_5de7_4175_8b53_e702a2d4f403
name: KHK
is: SBO:0000252
initial amount: NaN
is: P50053
has only substance units: false
constant: false
is encoded by: hsa:3795
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_a59e06ae_5bb5_4d0d_afd6_74fc8244e8cb
is: G5E9C5
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8654
has only substance units: false
name: PDE5A
initial amount: NaN
initial concentration: NaN

metaM tag hs e
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:17855
name: triglyceride
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN

metaM glc D l
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
is: HMDB00122
type: Species
constant: false
is: CHEBI:4167
initial amount: NaN
name: D-glucose
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b595cd2c_e2ce_438e_a923_03ced8bbe4ed
type: Species
constant: false
initial concentration: NaN
name: _AI684467_1_m
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI684467

metaM cs e deg1 l
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: CHEBI:57737
initial concentration: 1.0
is: HMDB00868
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_051d6158_1193_4e85_85ea_5a1a4c046bd2
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PDE9A
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_024989d1_1d6b_423f_8535_42fa6982feaf
initial amount: NaN
is: SBO:0000252
name: OGDH
is: Q02218
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4967
boundary condition: true
constant: false
type: Species

metaR r1566
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DOLPGT2 Ler
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.265
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction

metaM xoltriol c
initial amount: NaN
is: CHEBI:16496
is: SBO:0000247
constant: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
initial concentration: 1.0

metaR r0321
reversible: false
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16

metaR NTD7e
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
is described by: ECO:0000269
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
name: 5'-nucleotidase (AMP), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110035#
reversible: false

metaR RADH
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110035#
is: SBO:0000176
name: retinal dehydrogenase
reactant: MODEL1310110035#
type: Reaction

metaR FACOAL226
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR HPDCACRNt
modifier: MODEL1310110035#
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR r1567
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
kinetic law: MODEL1310110035#
type: Reaction
fast: false
modifier: MODEL1310110035#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
is: SBO:0000176
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_d1fd434f_212d_427a_bea9_40473ab7cf6f
is: SBO:0000252
initial amount: NaN
type: Species
name: MTHFD1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4522
constant: false
is: P11586
has only substance units: false

metaM udpacgal g
has only substance units: false
type: Species
is: HMDB00304
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
is: CHEBI:57847
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
constant: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e1bc0a0a_6f75_4453_9bdb_29ae450b7320
boundary condition: true
is: P16066
is encoded by: hsa:4881
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NPR1
has only substance units: false

metaM HC01412 x
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:61405
initial amount: NaN
name: trans-tetradec-2-enoyl-CoA(4-)
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_92155c9c_88e6_453f_874b_6b0994ed2237
initial concentration: NaN
boundary condition: true
has only substance units: false
is: E7EUT4
is: SBO:0000252
is encoded by: hsa:2597
constant: false
type: Species
initial amount: NaN
name: GAPDH

metaM ksi pre19 g
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 19
has only substance units: false
is: C00130
constant: false
is: CHEBI:58053
boundary condition: false
type: Species
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: HMDB00175
is: SBO:0000247

metaM 2docopencoa x
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaR FAOXC141C121x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR OCDCEAtr
name: fatty acid transport via diffusion
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
fast: false

metaR RE2999M
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM vacccoa c
is: SBO:0000247
type: Species
is: HMDB06521
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
name: vaccenyl coenzyme A
has only substance units: false

metaR r1568
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110035#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM phytcoa c
is: HMDB01359
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
name: phytanoyl-CoA(4-)
is: CHEBI:57391
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_152b51e8_f4b5_49f6_95ba_b667535bac9a
is encoded by: hsa:18
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: ABAT

metaM gln L c
is: SBO:0000247
constant: false
is: HMDB00641
name: L-glutamine
initial amount: NaN
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_02d967ec_ca66_4817_9f68_e48cea02f8be
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: B2RB13
name: ACSL6
is encoded by: hsa:23305
constant: false
initial amount: NaN
initial concentration: NaN

metaR FAS120COA
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C12:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
product: MODEL1310110035#

metaR r0937
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Transport reaction
reversible: true
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaM glu L m
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
type: Species
is: HMDB00148
is: CHEBI:29985
name: L-glutamate(1-)

metaR O2tm
name: O2 transport (diffusion)
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
reversible: true
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_c6d882c2_9d50_431e_a982_20b9277b62ff
constant: false
type: Species
is: O43306
name: ADCY6
has only substance units: false
is encoded by: hsa:112
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_b76fa1de_ce3a_47b4_892a_66a7e690c27d
is: O95479
name: H6PD
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9563
initial amount: NaN

metaR TYRTA
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
name: tyrosine transaminase
type: Reaction

metaR CITRtm
reversible: true
name: citrulline mitochondrial transport via proton antiport
modifier: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaR r0051
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000

metaR r0936
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_24e06c1e_6451_4d47_b008_a5b796e3a167
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: B4DK61
is: SBO:0000252
type: Species
is encoded by: hsa:51
name: ACOX1
has only substance units: false

metaM m2mpdol L c
type: Species
boundary condition: false
is: CHEBI:28049
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20

metaR FALDH
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
product: MODEL1310110035#
type: Reaction
reversible: true
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
reactant: MODEL1310110035#

metaM apoC Lys c
is: CHEBI:32551
is: HMDB00182
type: Species
boundary condition: false
name: Apocarboxylase (Lys residue)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C6H13N2OX CHARGE: 0

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_8d10eb10_2f36_42f6_ba55_f1accdc7f963
initial concentration: NaN
is: A8K761
is: SBO:0000252
is encoded by: hsa:4716
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: NDUFB10
type: Species

metaR r1428
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
reversible: true
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185

metaR RE2954C
fast: false
product: MODEL1310110035#
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
name: RE2954
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:

metaM ksi deg8 l
constant: false
boundary condition: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate I, degradation product 8
type: Species
has only substance units: false

metaM orot5p c
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: C01103
name: Orotidine 5'-phosphate
has only substance units: false
is: CHEBI:57538
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00218

metaR r1156
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176

metaR 2HCO3 NAt
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110035#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
is described by: ECO:0000269
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_3b95fe04_383b_4c3e_b340_363223634705
is: SBO:0000252
is encoded by: hsa:23563
boundary condition: true
type: Species
is: Q9GZS9
initial concentration: NaN
initial amount: NaN
constant: false
name: CHST5
has only substance units: false

metaM gln L e
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00641
boundary condition: false
is: CHEBI:18050
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_5da36882_4505_4100_92d1_6d86d6f71055
is: SBO:0000252
initial amount: NaN
name: ACAD9
type: Species
is encoded by: hsa:28976
is: Q9H845
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR H2O2tp
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
product: MODEL1310110035#

metaR r1429
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction

metaR CYTK11n
modifier: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (dCMP,dGTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110035#_2ea6ab0a_8961_46ad_91f5_65c08ac7d88f
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P11216
type: Species
constant: false
name: PYGB
boundary condition: true
is encoded by: hsa:5834
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_492aa150_bb55_4bcb_af4c_0d1f9981743b
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR r2347
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR FAOXC205C185m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7bbc1f62_0ade_493e_aff5_ea60888bd040
initial concentration: NaN
name: ASPA
constant: false
is: Q6FH48
boundary condition: true
is encoded by: hsa:443
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM 5oxpro e
name: 5-oxoprolinate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: HMDB00267
is: SBO:0000247
is: CHEBI:57606
constant: false
has only substance units: false

metaM hexccoa x
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: SBO:0000247
is: HMDB06459
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
has only substance units: false
initial amount: NaN

metaM HC01401 m
boundary condition: false
is: CHEBI:27668
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA

metaM malt e
has only substance units: false
initial concentration: 1.0
is: C00208
constant: false
boundary condition: false
is: HMDB00163
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: CHEBI:17306
initial amount: NaN
is: SBO:0000247
type: Species
name: Maltose

metaM his L m
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: CHEBI:15971
name: L-histidine
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110035#_625feeed_4ff2_4bc7_83e5_a267ef7bcc63
name: _R33828_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:R33828
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaM galgbside hs g
constant: false
initial amount: NaN
initial concentration: 1.0
name: galactosylgloboside
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:18259

metaM biocyt c
is: HMDB03134
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
name: Biocytin

metaR SPMTDe
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000134
type: Reaction
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: SPMTDe
kinetic law: MODEL1310110035#

metaR GLUPRT
is described by: ECO:0000269
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.14
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110035#

metaR r0074
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176

metaM udpacgal l
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
is: HMDB00304
initial concentration: 1.0
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
initial amount: NaN
type: Species
is: SBO:0000247

metaR G14T12g
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110035#_db0a6c15_23f1_46d1_9932_48146750fdae
initial amount: NaN
is encoded by: hsa:6184
is: SBO:0000297
is encoded by: hsa:6185
has only substance units: false
boundary condition: true
has part: Q53G02
type: Species
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:1650
constant: false
is encoded by: hsa:1603
has part: P39656
initial concentration: NaN
has part: P04844
has part: P04843

metaR GLUDym
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
name: glutamate dehydrogenase (NADP), mitochondrial
fast: false
is described by: ECO:0000269
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_34e34d7a_1c2f_422b_937e_f614dafb1167
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q8NCG5
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CHST4
is encoded by: hsa:10164

metaR RE1517M
type: Reaction
name: RE1517
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR RNDR2
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (GDP)
reactant: MODEL1310110035#
fast: false
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110035#

metaM thmpp c
is: C00068
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:45931
type: Species
has only substance units: false
is: SBO:0000247
name: Thiamine diphosphate
is: HMDB01372
constant: false

metaR r0932
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM ala L c
is: SBO:0000247
has only substance units: false
is: CHEBI:16977
type: Species
constant: false
is: HMDB00161
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
name: L-alanine
initial concentration: 1.0

metaR r0055
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
kinetic law: MODEL1310110035#
fast: false
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000000

metaR PCHOLP hs
is described by: ECO:0000269
reversible: false
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#

metaR LEUKTRE4t
name: leukotriene E4 transport
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaM pro L e
is: CHEBI:17203
initial concentration: 1.0
initial amount: NaN
type: Species
name: L-proline
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162

metaM tethex3 e
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
boundary condition: false
is: HMDB02007
has only substance units: false
name: tetracosahexaenoic acid, n-3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_0478daac_c267_4f70_beeb_615ff3ee6aa3
name: HADHA
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3030
is: E9KL44
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1a81b6db_dc28_4227_a4f3_0adbe27c6263
is: SBO:0000252
name: DLAT
constant: false
is encoded by: hsa:1737
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q86YI5
boundary condition: true

metaR 10FTHFtm
is described by: ECO:0000000
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reactant: MODEL1310110035#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000304
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaM dolmanp U c
initial amount: NaN
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
boundary condition: false
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR RNDR3
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: ribonucleoside-diphosphate reductase (CDP)
reactant: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000176

metaR NADPtru
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110035#

metaR r0931
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110035#

metaR ASNGLNNaEx
product: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000269

metaM 44mzym r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: CHEBI:18364
has only substance units: false
name: 14-demethyllanosterol
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB01286

metaM hs deg3 l
initial concentration: 1.0
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: heparan sulfate, degradation product 3
type: Species
constant: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
has only substance units: false

metaR r2346
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110035#
is: SBO:0000185

metaM dheas e
boundary condition: false
is: CHEBI:57905
is: HMDB01032
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6aa22d45_d51d_48ed_8fa8_a17c8f62ca28
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5336
constant: false
initial concentration: NaN
boundary condition: true
name: PLCG2
is: P16885

metaM dolglcp L c
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15812
is: SBO:0000247

metaM thmmp m
boundary condition: false
is: CHEBI:37575
is: SBO:0000247
has only substance units: false
name: thiamine(1+) monophosphate(2-)
type: Species
initial amount: NaN
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
is: HMDB02666
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_688b37d1_86a0_4e0d_b788_f903cef30b89
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: B3GALNT1
constant: false
initial concentration: NaN
is: Q8TDY1
is encoded by: hsa:8706
is: SBO:0000252

metaR LINKDEG4ly
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110035#

metaR AIRCr
is: SBO:0000176
kinetic law: MODEL1310110035#
name: phosphoribosylaminoimidazole carboxylase
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.3.2.6

metaM g3p c
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
boundary condition: false
is: CHEBI:58027
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
initial amount: NaN
is: HMDB01112
is: C00661
has only substance units: false

metaR DMATTx
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
name: dimethylallyltranstransferase
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110035#
is described by: ECO:0000134

metaR PDE4n
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110035#
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
is described by: ECO:0000269

metaR HEX4
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
is: SBO:0000176
name: hexokinase (D-mannose:ATP)
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaM dolp U c
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: dolichyl phosphate(2-)
type: Species
is: CHEBI:57683
boundary condition: false
has only substance units: false

metaM ala L e
initial concentration: 1.0
name: L-alanine
is: SBO:0000247
is: CHEBI:16977
boundary condition: false
initial amount: NaN
is: HMDB00161
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
has only substance units: false

metaM fuc1p L c
name: L-Fucose 1-phosphate
has only substance units: false
initial amount: NaN
is: CHEBI:28319
is: HMDB01265
constant: false
type: Species
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR DATPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
name: dATP diffusion in nucleus
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false

metaR r2343
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110035#_a506971d_9d4b_4972_af90_18dbc6d50c40
is encoded by: hsa:5289
type: Species
is: Q8NEB9
initial amount: NaN
name: PIK3C3
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR FUMtm
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
kinetic law: MODEL1310110035#
name: fumarate transport, mitochondrial
type: Reaction
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000269
product: MODEL1310110035#
is: SBO:0000185

metaM pcrn c
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB00824

metaM tethex3 c
boundary condition: false
constant: false
initial amount: NaN
is: HMDB02007
initial concentration: 1.0
type: Species
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e2221a33_928d_486c_ab45_fa3e8dc72985
type: Species
is: SBO:0000252
boundary condition: true
is: P57103
initial amount: NaN
constant: false
is encoded by: hsa:6547
name: SLC8A3
initial concentration: NaN
has only substance units: false

metaR HSD3A1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110035#
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
type: Reaction

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_cce90f0c_c266_444c_aa8d_8f06eed28254
initial amount: NaN
initial concentration: NaN
is: Q9HAY6
boundary condition: true
type: Species
constant: false
name: BCMO1
is encoded by: hsa:53630
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_a93aed8e_f0ce_4b03_bd27_f1811283448d
boundary condition: true
constant: false
is encoded by: hsa:47
initial amount: NaN
has only substance units: false
name: ACLY
is: SBO:0000252
type: Species
initial concentration: NaN

metaR DUDPtn
type: Reaction
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110035#
product: MODEL1310110035#

metaM xoltriol m
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16496
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
constant: false
is: HMDB01457

metaR PPPG9tm
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
name: protoporphyrinogen IX mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
fast: false
is described by: ECO:0000000

metaM 4hglusa m
is: HMDB06556
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
has only substance units: false
boundary condition: false
is: CHEBI:27809
initial amount: NaN
type: Species
name: L-4-hydroxyglutamic semialdehyde

metaM phaccoa c
initial concentration: 1.0
initial amount: NaN
is: HMDB06503
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
name: phenylacetyl-CoA(4-)
has only substance units: false
is: CHEBI:57390
constant: false
is: SBO:0000247
boundary condition: false

metaR r2344
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM pail5p hs n
is: CHEBI:57795
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0

metaM dheas c
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: CHEBI:57905
is: HMDB01032
initial concentration: 1.0
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_bfd3aeac_9c98_48dd_81aa_4e2ac0c58516
is: SBO:0000252
name: _728226_1_m
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:728226
has only substance units: false
constant: false

metaR GGH 7DHFe
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
product: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaR AG13T14g
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c9633963_bee1_4c9b_9b03_32361e9c3513
name: DYLX2
is: F5H123
constant: false
is encoded by: hsa:9856
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM asn L m
has only substance units: false
initial concentration: 1.0
name: L-asparagine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00168
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR r2118
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2509
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM arachdcoa c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
boundary condition: false
is: CHEBI:57368
is: HMDB06523
type: Species
has only substance units: false
name: arachidonoyl-CoA(4-)

metaR ACACT7p
reversible: false
product: MODEL1310110035#
is: SBO:0000176
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110035#_8e9eff27_d073_4c4e_9ddd_36fcb7df0777
boundary condition: true
type: Species
is: Q969N2
initial amount: NaN
is encoded by: hsa:51604
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PIGT

metaR r1580
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACETONEt2m
modifier: MODEL1310110035#
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

metaM 2dr1p c
is: SBO:0000247
is: C00672
type: Species
constant: false
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false
is: CHEBI:58576
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
is: HMDB01351
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_508b5b88_ab8a_48e5_b667_bd18628d9348
name: _BE966236_1_m
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:BE966236
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_e39a05bc_6428_4d64_93e5_b03aae68b8f6
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: P32929
boundary condition: true
is encoded by: hsa:1491
initial concentration: NaN
type: Species
name: CTH

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0bb26aa9_3664_4d56_8420_b3a7745ccc3d
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:953
name: ENTPD1
is: Q86VV3
is: SBO:0000252
type: Species

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_d1406469_ace7_4451_a70b_f8e8f37714e7
is encoded by: hsa:1743
has part: P09622
boundary condition: true
is encoded by: hsa:8050
has only substance units: false
constant: false
has part: O00330
is encoded by: hsa:1738
initial amount: NaN
name: DLD:DLST:OGDH:PDHX
is: SBO:0000297
has part: Q02218
has part: P36957
is encoded by: hsa:4967
type: Species
initial concentration: NaN

metaR r2117
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_f9291e58_e20c_4ab1_af4e_8a718e1ce822
name: _T83654_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:T83654
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_53973da3_2c7a_4b85_80b7_2d07bad08c98
name: ALG3
initial amount: NaN
is: Q92685
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10195
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_dc5ffa84_de3d_44eb_83af_5578801842be
initial concentration: NaN
is encoded by: hsa:229
name: ALDOB
type: Species
has only substance units: false
is: P05062
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_d2541a8d_d803_4d82_a1d6_9a678a4e8373
has only substance units: false
type: Species
is encoded by: hsa:6390
boundary condition: true
name: SDHB
is: P21912
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR S6T2g
reversible: false
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_6848450a_7f98_4af5_a19e_761ade67dca1
name: COX8A
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1351
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q53XN1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_aa9a0738_8ff7_42d7_98cb_488a9d8a6f1e
is: Q9NYQ3
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51179
constant: false
initial amount: NaN
boundary condition: true
name: HAO2

metaR FOAXC122C101x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR SERASNNaEx
kinetic law: MODEL1310110035#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000185

metaR r0603
fast: false
product: MODEL1310110035#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reactant: MODEL1310110035#
modifier: MODEL1310110035#

metaM itacon m
type: Species
constant: false
is: CHEBI:17240
initial amount: NaN
is: SBO:0000247
name: itaconate(2-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02092
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

metaR PROSTGE2t
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR AG13T13g
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
boundary condition: false
is: CHEBI:61648
name: VI2Fuc-nLc6
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_55fc7b7c_768c_4d56_aa20_6f0a500bd604
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: O60701
name: UGDH
is encoded by: hsa:7358

metaM met L e
is: CHEBI:16643
boundary condition: false
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00696
type: Species
constant: false

metaR r0494
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
modifier: MODEL1310110035#
fast: false

metaR RPE
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.1.3.1
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110035#
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176

metaR r2119
is: SBO:0000185
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110035#
reversible: true
type: Reaction

metaM dece4coa x
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
boundary condition: false
name: 4-decenoylcoa
initial concentration: 1.0
has only substance units: false
is: HMDB02145

http://identifiers.org/biomodels.db/MODEL1310110035#_b5da6fb4_f955_4883_88a4_1fab7de8a8c3
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: P50747
name: HLCS
initial amount: NaN
is encoded by: hsa:3141
constant: false

metaR NACHEX21ly
modifier: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_76403caa_49e5_4238_a53c_e09d1f880658
has only substance units: false
initial concentration: NaN
name: ATP1A4:ATP1B1
type: Species
has part: Q13733
initial amount: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:480
constant: false

metaM pail35p hs c
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:57923
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)

metaR RE2541E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110035#
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#

metaM hs deg14 l
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16126
boundary condition: false
name: heparan sulfate, degradation product 14

http://identifiers.org/biomodels.db/MODEL1310110035#_33bf87da_219b_4921_ba79_3f888e6842e7
is: E7EML0
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC4A8
initial amount: NaN
is encoded by: hsa:9498
boundary condition: true
constant: false

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:27402
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110035#_97406253_2174_4ce7_b0c2_727c90ecf4ee
is: B7Z1R0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC4A10
has only substance units: false
type: Species
is encoded by: hsa:57282
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
constant: false
has only substance units: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
is: CHEBI:26174
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: I-antigen

metaR r2328
product: MODEL1310110035#
reversible: true
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR CLOHtex2
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110035#
name: chloride transport via hydroxide countertransport (2:1)
kinetic law: MODEL1310110035#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM xol7ah3 c
initial amount: NaN
is: CHEBI:28540
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455

metaR r0791
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110035#_9d922034_4225_4201_8c12_5057d9e5084e
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: O43924
initial amount: NaN
boundary condition: true
is encoded by: hsa:5147
has only substance units: false
name: PDE6D

metaR r2114
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
reversible: true
type: Reaction
reactant: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185

metaR NDPK9n
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110035#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_75b08f91_e189_4943_b4eb_74b51afb6fd1
initial concentration: NaN
initial amount: NaN
name: _206_1_c
type: Species
is encoded by: hsa:206
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_8db387c8_581b_478e_86da_26beaef193ac
type: Species
name: DPM2
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8818
has only substance units: false
is: SBO:0000252

metaR RDH2
name: retinol dehydrogenase (9-cis,NADH)
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.315

metaM HC02210 e
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:34939
type: Species
name: prostaglandin-d3
is: SBO:0000247

metaM CE5119 m
constant: false
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57923

metaR r2327
product: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM tdchola x
name: taurochenodeoxycholate
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00951

metaR FAOXC164m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR ESTRADIOLtr
is described by: ECO:0000000
name: estradiol intracellular transport
product: MODEL1310110035#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r0792
product: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20

metaR HEXCCOAtx
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110035#
name: fatty acid intracellular transport
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
is: SBO:0000185
type: Reaction

metaR r2506
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000

metaM succ e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:30031
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
name: succinate(2-)
boundary condition: false
type: Species

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM galgalgalthcrm hs c
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
constant: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: CHEBI:12936
boundary condition: false
initial amount: NaN

metaR MG1er
modifier: MODEL1310110035#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110035#
is described by: ECO:0000000

metaM mgacpail hs r
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: SBO:0000247
type: Species
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:7896
initial concentration: 1.0
constant: false
has only substance units: false
is: C00249
boundary condition: false
is: HMDB00220

metaR AKR1C1
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
modifier: MODEL1310110035#
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reversible: false
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.1.20
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000

metaR RDH3
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
reversible: true
name: retinol dehydrogenase (11-cis,NADH)

http://identifiers.org/biomodels.db/MODEL1310110035#_27105559_1eca_4e1e_a815_c1727301b60d
type: Species
boundary condition: true
is encoded by: hsa:3295
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: E9PB82
name: HSD17B4
has only substance units: false

metaR RE3301C
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
reactant: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
name: RE3301
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000

metaM tethex3coa x
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06243
initial amount: NaN
name: tetracosahexaenoyl coenzyme A
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
boundary condition: false
is: C16168
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205478
type: Species

metaM ala L m
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
initial concentration: 1.0
name: L-alanine
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16977
constant: false
is: SBO:0000247

metaR OCTAt
type: Reaction
fast: false
name: Octanoate transport via diffusion
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR

metaR r2507
name: Utilized transport
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7476e371_3079_4bf9_aea6_9f276e79f3b5
boundary condition: true
constant: false
is: B2RD24
type: Species
is: SBO:0000252
is encoded by: hsa:25902
name: MTHFD1L
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR THYMDt1
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:9693094 NOTES:TDV
kinetic law: MODEL1310110035#
fast: false
name: thymd transport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaM tsul m
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
is: CHEBI:16094
is: HMDB00257
initial concentration: 1.0
boundary condition: false
name: thiosulfate(2-)
constant: false

metaR RPI
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
reactant: MODEL1310110035#
name: ribose-5-phosphate isomerase
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR r2116
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#

metaR NACHEX24ly
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110035#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal

metaM HC02210 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: prostaglandin-d3
constant: false
is: CHEBI:34939

http://identifiers.org/biomodels.db/MODEL1310110035#_e61c26d6_b331_4e31_a0ec_0d05af9a8e3e
initial amount: NaN
is encoded by: hsa:251
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: P10696
name: ALPPL2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_81dfbe3c_7240_4d49_a89a_504e006a3094
is encoded by: hsa:51102
name: MECR
has only substance units: false
initial amount: NaN
is: Q9BV79
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r2508
name: Utilized transport
fast: false
product: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185

metaM succ c
is: C00042
type: Species
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30031
constant: false
name: Succinate
initial amount: NaN
boundary condition: false

metaR FAS140COA
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: MODEL1310110035#

metaR RBFK
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR r2329
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR PHYCBOXL
name: L-Phenylalanine carboxy-lyase
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000212
product: MODEL1310110035#
reversible: false

metaR PCHOLHSTDe
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: PCHOLHSTDe
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r2115
modifier: MODEL1310110035#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR RDH1
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000269
product: MODEL1310110035#
name: retinol dehydrogenase (all-trans)
type: Reaction
reversible: true

metaR ILEt5m
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
name: Isoleucine mitochondrial transport

metaR H2MTer U
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_80350083_a3c7_4de4_b31b_ff57c3cda439
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:587
is: O15382
is: SBO:0000252
name: BCAT2
type: Species
boundary condition: true
has only substance units: false

metaM apoC c
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
is: CHEBI:33190
has only substance units: false
is: HMDB11111
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
constant: false

metaR r1588
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaM tsul c
initial amount: NaN
is: HMDB00257
boundary condition: false
is: CHEBI:16094
has only substance units: false
constant: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM aicar c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C04677
boundary condition: false
is: CHEBI:58475
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
type: Species
is: HMDB01517
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_c5d254d8_31f5_4dda_b62f_a3e2ab179ca9
has only substance units: false
is: SBO:0000252
name: TSTA3
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q13630
is encoded by: hsa:7264

http://identifiers.org/biomodels.db/MODEL1310110035#_22181d4f_a455_434e_9609_2ad92c9fe2c4
is: SBO:0000252
name: TXNRD2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10587
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r2110
modifier: MODEL1310110035#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_cbd4858c_a212_43a5_9ce1_3a4799cbd85e
is: SBO:0000252
is: Q86YT5
is encoded by: hsa:284111
name: SLC13A5
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR FAOXC240200x
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:0 -> c20:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110035#_adedc7c8_3728_4343_8746_1365398c908e
name: CPT1B
boundary condition: true
is: Q92523
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1375
initial amount: NaN
is: SBO:0000252

metaM asn L e
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
initial concentration: 1.0
is: CHEBI:17196
type: Species
constant: false
is: HMDB00168
boundary condition: false
initial amount: NaN
name: L-asparagine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_a8463021_c82a_45bd_93ce_fedf49a00e41
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10632
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: ATP5L
is: O75964

http://identifiers.org/biomodels.db/MODEL1310110035#_44277b73_3e42_467b_9ab1_a99e59f7db9f
boundary condition: true
constant: false
is: Q9BRC7
type: Species
initial amount: NaN
initial concentration: NaN
name: PLCD4
is: SBO:0000252
is encoded by: hsa:84812
has only substance units: false

metaR ARGtiDF
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
modifier: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000269
name: L-arginine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_b28634b4_d028_4786_807c_465ddab55ca7
initial amount: NaN
is: SBO:0000252
name: _U37519_1_e
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:U37519
boundary condition: true

metaR r1587
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaR r0340
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.1.38

metaR G6PDH2rer
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is: SBO:0000176

metaR sink citr LPAREN c RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: citrulline sink
type: Reaction

metaR RBTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
reactant: MODEL1310110035#
name: ribitol transport via passive diffusion
product: MODEL1310110035#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaR CYSGLNNaEx
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: false

metaM hdd2coa x
name: (E)-hexadec-2-enoyl-CoA(4-)
is: CHEBI:61526
is: HMDB03945
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR DNDPt29m
product: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110035#
name: dCDP transport via dADP antiport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_733cebae_2699_4410_8068_256388f0cbc6
name: GMDS
is encoded by: hsa:2762
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O60547
constant: false

metaM 4ppan c
is: SBO:0000247
constant: false
type: Species
name: D-4'-Phosphopantothenate
initial amount: NaN
is: C03492
boundary condition: false
has only substance units: false
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
is: CHEBI:10986

metaR r1586
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f1e7908f_e944_474f_b1c0_aa3227866ae9
name: PFAS
is encoded by: hsa:5198
is: Q6P4B4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR r2112
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#

metaR TAGt
kinetic law: MODEL1310110035#
name: triacylglycerol transport
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_7f404b45_2af4_40a2_bf42_af496c9f27b1
initial concentration: NaN
name: PRDX3
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10935
is: P30048
boundary condition: true
has only substance units: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_8dc5818e_dde3_48cb_9f22_bcc7658f8390
is: B4DUY1
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: STARD3
is encoded by: hsa:10948
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_ad861393_fd90_4698_9422_526c1e509005
initial amount: NaN
has part: P07327
constant: false
is encoded by: hsa:124
name: ADH1A:ADH1B
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000297

metaR ODECOAtx
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport

metaR ASCBt4
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: L-ascorbate transport via proton symport
is: SBO:0000185
reactant: MODEL1310110035#
fast: false

metaR FAOXC164x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR r1585
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_de4c387c_2cb5_4e05_90c7_161f4bad6f6c
name: DHFR
is: P00374
is encoded by: hsa:1719
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_00faac61_7455_40ed_9d58_cb4906f80848
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:22305
name: _22305_2_c
has only substance units: false
initial amount: NaN

metaR FOLt2le
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000134
reversible: true
type: Reaction
name: folate transport via anion exchange

metaR r1858
reactant: MODEL1310110035#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_4784a90c_31c4_4498_a49d_85ba1e3065a1
is: Q99519
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4758
initial amount: NaN
initial concentration: NaN
name: NEU1
type: Species

metaR PPA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
name: inorganic diphosphatase
reversible: false
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR S4TASE3ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reversible: true
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_5ee1f4dd_0d73_4e68_870a_19d0d2d729bc
is: P24752
initial amount: NaN
constant: false
boundary condition: true
name: ACAT1
is encoded by: hsa:38
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM h2o x
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: C00001
type: Species
is: HMDB02111
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM HC02121 c
is: CHEBI:58758
boundary condition: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
name: S-(hydroxymethyl)glutathione(1-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaR r1584
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
type: Reaction

metaM met L c
is: CHEBI:16643
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: L-methionine
is: HMDB00696

metaM bildglcur e
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_6d897f94_6b59_4d81_b90e_305f0d826314
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q546Y9
boundary condition: true
initial concentration: NaN
constant: false
name: AICDA
is encoded by: hsa:57379

metaR D LACt2
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
name: D-lactate transport via proton symport
product: MODEL1310110035#

metaR DNDPt17m
fast: false
is: SBO:0000185
type: Reaction
reversible: false
name: dUDP transport via dCDP antiport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaM dhf m
type: Species
name: dihydrofolate(2-)
has only substance units: false
is: SBO:0000247
is: HMDB01056
is: CHEBI:57451
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
constant: false
initial amount: NaN

metaR GLCAASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110035#

metaR ACt2m
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
name: acetate mitochondrial transport via proton symport
reversible: true
type: Reaction
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9c8799d1_48bb_4ce3_9a30_a3b90d1975ef
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6391
boundary condition: true
is: Q99643
name: SDHC
constant: false
type: Species

metaM apoC m
boundary condition: false
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false
name: Apocarboxlase (no lys residue)
is: SBO:0000247
is: CHEBI:32551
initial concentration: 1.0
constant: false
is: HMDB00182
type: Species

metaR r1583
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000

metaR r1852
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR FAOXC122m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM succ m
initial concentration: 1.0
is: HMDB00254
has only substance units: false
name: Succinate
is: C00042
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
type: Species

metaR MAN6PI
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/5.3.1.8
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110035#
name: mannose-6-phosphate isomerase
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ae77b088_1371_4b0f_8da3_a17cb82f466e
is: Q7Z4W1
is encoded by: hsa:51181
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: DCXR
constant: false

metaM sucr e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992
type: Species
initial concentration: 1.0
is: HMDB00258
constant: false
is: SBO:0000247
initial amount: NaN
name: Sucrose
has only substance units: false
is: C00089
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d47c7e1b_bbf7_4a7d_9c73_1582dfbd85bb
boundary condition: true
is: P43353
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:221
initial amount: NaN
is: SBO:0000252
name: ALDH3B1

metaM m6mpdol L r
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
type: Species
is: CHEBI:37635
boundary condition: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR ABO5g
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ

metaM tsul e
initial concentration: 1.0
constant: false
is: CHEBI:16094
has only substance units: false
boundary condition: false
name: thiosulfate(2-)
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
is: SBO:0000247
is: HMDB00257

metaM xu5p D c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: D-xylulose 5-phosphate(2-)
constant: false
boundary condition: false
type: Species
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial concentration: 1.0
is: HMDB00868

metaM bildglcur c
constant: false
boundary condition: false
is: HMDB03325
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
type: Species
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110035#_e599550e_260a_4595_ade9_cbcac570e19b
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3032
name: HADHB
type: Species
initial amount: NaN
is: P55084
initial concentration: NaN

metaM asn L c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:17196
name: L-asparagine
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
constant: false
is: HMDB00168
initial amount: NaN

metaR ATPtn
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110035#
name: ATP diffusion in nucleus
reactant: MODEL1310110035#

metaM xol7ah3 m
is: CHEBI:28540
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_e3ce68da_7eae_45b9_b9d0_5cc577256e93
initial concentration: NaN
constant: false
name: COX7B2
is: SBO:0000252
is encoded by: hsa:170712
is: Q8TF08
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR GGH 10FTHF7GLUe
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
reversible: false
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR q10h2tc
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110035#

metaR DITPtn
reactant: MODEL1310110035#
name: dITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185

metaR GNDer
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
reversible: false
is described by: ECO:0000000
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
fast: false
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_83b88793_feba_4305_9d1a_c4fd3a67bb71
type: Species
is: SBO:0000252
is encoded by: hsa:27068
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: PPA2

metaR r1581
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_1b627bf6_ce5a_4751_bc53_10a5b44e92b1
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2181
initial amount: NaN
constant: false
is: SBO:0000252
is: B3KMA6
has only substance units: false
name: ACSL3

http://identifiers.org/biomodels.db/MODEL1310110035#_07bfd9a4_84b8_4c2b_a151_cf2480c076db
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:55312
name: RFK
initial concentration: NaN
type: Species
is: B2RDZ2
has only substance units: false

metaM ksii core2 deg5 l
boundary condition: false
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 5
initial concentration: 1.0
type: Species
is: HMDB00143
has only substance units: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
initial amount: NaN
constant: false
is: SBO:0000247

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR ADRNt
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110035#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR GLYCTDle
product: MODEL1310110035#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9d3c0fdc_2759_4ff2_a117_56afda8f1549
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
type: Species
is encoded by: hsa:513
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:514
boundary condition: true

metaR ARACHDCOAtx
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
product: MODEL1310110035#

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaM ksi deg40 l
notes: FORMULA: C40H68N2O31 CHARGE: 0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 40
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_17f81b8d_4577_49b6_9486_f3706e81b109
is: SBO:0000252
is encoded by: hsa:10317
name: B3GALT5
constant: false
is: Q9Y2C3
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaR ACOAO7p
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000176
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is described by: ECO:0000269

metaM retinol c
initial amount: NaN
name: retinol
type: Species
is: SBO:0000247
constant: false
is: HMDB00305
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
has only substance units: false
is: CHEBI:50211

metaR P4508B11r
type: Reaction
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is version of: http://identifiers.org/ec-code/1.14.13.95
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
name: sterol 12-alpha-hydroxylase

http://identifiers.org/biomodels.db/MODEL1310110035#_d2d2db84_2838_493a_a9d1_663695eeaf25
initial amount: NaN
is encoded by: hsa:6549
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9UBY0
name: SLC9A2
type: Species

metaR FAOXC121x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR C226CRNt
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: C226 transport into the mitochondria
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110035#

metaR GAMt1r
product: MODEL1310110035#
name: glucosamine transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction

metaR KHK
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
name: ketohexokinase

metaR BILDGLCURtr
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110035#
name: glucuronidated compound transport
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is: SBO:0000185

metaR IDOURtly
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reversible: true
kinetic law: MODEL1310110035#
name: iduronate transport into lysososme
fast: false
is described by: ECO:0000269

metaM h l
is: CHEBI:24636
is: C00080
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial concentration: 1.0
name: proton
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_c1760560_429a_45b7_8c10_1141b5e45cb8
initial amount: NaN
initial concentration: NaN
is: P54687
type: Species
has only substance units: false
is encoded by: hsa:586
name: BCAT1
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4b3f1964_875e_4b34_9e9b_5e467af2b276
initial amount: NaN
has only substance units: false
name: CCBL1
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:883
is: Q16773
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_c312e8da_15dd_4f09_b63d_c83502a1585b
has only substance units: false
constant: false
boundary condition: true
is: O60733
is encoded by: hsa:8398
type: Species
initial amount: NaN
is: SBO:0000252
name: PLA2G6
initial concentration: NaN

metaR EX 34hpp
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR NTP3e
reactant: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110035#
name: nucleoside-triphosphatase (GTP)
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9579138d_9cc7_46c3_8fbc_fdc33a0a1d5e
initial concentration: NaN
type: Species
is encoded by: hsa:1806
initial amount: NaN
is: SBO:0000252
name: DPYD
is: Q12882
constant: false
has only substance units: false
boundary condition: true

metaM lac L c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16651
is: HMDB00190
type: Species
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
initial amount: NaN

metaR SGALSIDEtl
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
name: sgalside hs intracellular transport
product: MODEL1310110035#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false

metaM xylt e
is: HMDB02917
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17151
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: xylitol

http://identifiers.org/biomodels.db/MODEL1310110035#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaR EICOSTETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM ksi deg36 l
name: keratan sulfate I, degradation product 36
is: HMDB00143
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: CHEBI:12936
boundary condition: false

metaR CSNATm
kinetic law: MODEL1310110035#
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
name: carnitine O-aceyltransferase, mitochondrial

metaM succ x
initial concentration: 1.0
is: C00042
is: CHEBI:30031
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00254
name: Succinate
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
has only substance units: false

metaM citr L c
is: HMDB00904
has only substance units: false
is: CHEBI:16349
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_144cd4da_3cfd_49f6_a1cf_1a5dd0f9579d
type: Species
is: Q9NWU1
boundary condition: true
is encoded by: hsa:54995
constant: false
initial concentration: NaN
name: OXSM
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM dhf c
name: 7,8-Dihydrofolate
is: CHEBI:57451
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: C00415
constant: false
is: HMDB01056
type: Species
boundary condition: false

metaR FUT14g
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110035#

metaM citr L e
is: SBO:0000247
has only substance units: false
is: CHEBI:16349
initial amount: NaN
initial concentration: 1.0
name: citr_L[e]
boundary condition: false
constant: false
is: HMDB00904
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaM datp n
is: C00131
is: CHEBI:61404
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: dATP
is: HMDB01532
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false

metaM gd3 hs g
initial concentration: 1.0
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28424
has only substance units: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM xylt c
is: SBO:0000247
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
boundary condition: false
is: CHEBI:17151
type: Species
is: HMDB02917
has only substance units: false
initial concentration: 1.0
name: xylitol

metaR PHEMEt
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
modifier: MODEL1310110035#
reversible: false
name: heme transport
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110035#_63979e76_3850_4eb1_bee8_3c77e4cf3884
constant: false
name: SPTLC2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9517
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: O15270

metaR r2330
product: MODEL1310110035#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM lac L e
constant: false
type: Species
initial concentration: 1.0
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16651
has only substance units: false
name: (S)-lactate

metaM dcyt c
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00014
is: CHEBI:15698
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: C00881
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaM crn c
is: HMDB00062
is: CHEBI:16347
name: L-Carnitine
is: C00318
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN

metaR r1579
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PPBNGS
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000176
fast: false
name: porphobilinogen synthase
is version of: http://identifiers.org/ec-code/4.2.1.24
reversible: false
reactant: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#

metaM HC01223 m
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340

metaM datp m
is: C00131
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false
is: CHEBI:61404
initial amount: NaN
type: Species
name: dATP
constant: false
has only substance units: false
is: HMDB01532

metaM orot c
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: Orotate
is: C00295
initial concentration: 1.0
is: CHEBI:30839
type: Species
is: HMDB00226

metaM xol7ah2 c
is: CHEBI:28047
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0ec05fb5_f904_4b68_bec6_90eef47dad57
initial amount: NaN
is encoded by: hsa:6487
is: Q96L53
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: ST3GAL3
boundary condition: true

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM dhf e
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01056
type: Species
is: CHEBI:57451
constant: false
initial amount: NaN

metaR r0926
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#

metaR DNDPt8m
name: dADP transport via dUDP antiport
reversible: false
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000269

metaR FAOXC181C161x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR HS3ly
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: heparan-N-sulfatase, lysosomal
modifier: MODEL1310110035#

metaM dece4coa m
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB02145
name: 4-decenoylcoa
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false

metaM mi1p D n
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
has only substance units: false
type: Species
is: CHEBI:58433
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02985
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)

metaM C05279 m
initial amount: NaN
is: CHEBI:28387
initial concentration: 1.0
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
has only substance units: false
is: HMDB11123
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_18eb802f_4a94_4547_8951_2269858bf76e
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6532
boundary condition: true
initial concentration: NaN
name: SLC6A4
is: P31645
is: SBO:0000252
has only substance units: false

metaM m5mpdol L r
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
boundary condition: false
is: CHEBI:37634

metaM C05957 r
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: HMDB02710
is: SBO:0000247
is: CHEBI:27485
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Prostaglandin J2
type: Species

metaM dcdp c
initial concentration: 1.0
name: dCDP
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
is: HMDB01245
is: CHEBI:58593
is: C00705
is: SBO:0000247
constant: false

metaM acac m
initial concentration: 1.0
name: acetoacetate
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00060
is: CHEBI:13705
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN

metaR ADKd
is: SBO:0000176
modifier: MODEL1310110035#
name: adenylate kinase (d form)
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM HC01403 m
is: SBO:0000247
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaM acetone m
name: acetone
is: HMDB01659
constant: false
boundary condition: false
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15347

metaM kynate c
constant: false
type: Species
initial amount: NaN
is: HMDB00715
is: SBO:0000247
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: CHEBI:58454
has only substance units: false
name: kynurenate
initial concentration: 1.0
boundary condition: false

metaM arachdcoa x
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
constant: false
is: SBO:0000247

metaR H8TAer
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
name: H8 transamidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_87b71e76_a053_4dd5_9081_92d315520c5b
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2592
constant: false
boundary condition: true
is: SBO:0000252
name: GALT
is: B4E097
type: Species
initial amount: NaN

metaR r0331
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM CE5116 x
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
boundary condition: false
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
is: SBO:0000247
type: Species
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110035#_3b43aa5f_baae_437c_baaa_be71d2be90c4
is encoded by: hsa:8836
is: Q92820
name: GGH
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR SUCCt4 2
product: MODEL1310110035#
name: succinate transport via sodium symport
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
modifier: MODEL1310110035#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM ser L c
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
name: L-serine
type: Species
is: CHEBI:17115
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: proton
type: Species
constant: false
is: C00080
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_4d51c97c_6784_411f_87da_45bb17d116bc
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: ATP1A2
is: P50993
is encoded by: hsa:477
boundary condition: true
constant: false
has only substance units: false

metaM guln c
is: CHEBI:13115
has only substance units: false
is: HMDB03290
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: L-gulonate
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_bc91aecb_db7f_40f0_a2aa_e4a5855a0102
boundary condition: true
has part: Q6FIH7
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
is encoded by: hsa:516

metaM orot e
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:30839
is: SBO:0000247
name: orotate
is: HMDB00226
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0

metaR r1010
type: Reaction
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110035#

metaM fprica c
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01439
has only substance units: false
boundary condition: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58467
is: C04734
type: Species
initial concentration: 1.0

metaR Rtotaltl
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
name: fatty acid intracellular transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9420beb4_8e84_4271_9a68_337c158000a5
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q9BZM2
type: Species
name: PLA2G2F
is encoded by: hsa:64600
is: SBO:0000252

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
is: CHEBI:57795
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species

metaR CSNATp
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
is described by: ECO:0000304
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
type: Reaction

metaM h n
is: SBO:0000247
initial amount: NaN
name: proton
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
is: CHEBI:24636
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f2b90fd9_e07f_448d_9dce_e8360e1e9fbc
initial amount: NaN
is: SBO:0000252
name: ACO1
is encoded by: hsa:48
has only substance units: false
initial concentration: NaN
is: P21399
type: Species
boundary condition: true
constant: false

metaR r1578
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR r1011
name: Transport reaction
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
fast: false
product: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_5950f005_9b52_47c3_bd4e_9fcb83ac18a0
name: COX1
is: Q7GXY8
boundary condition: true
is encoded by: hsa:4512
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR KSII CORE2t
type: Reaction
reversible: false
is described by: ECO:0000000
name: keratan sulfate II (core2) transport, golgi to extracellular
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM glygn2 c
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00187
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:17115
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b8db292d_4b41_4c40_9962_87145cb72b03
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: NMNAT2
is encoded by: hsa:23057

metaM HC00460 c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
type: Species
is: CHEBI:58044
initial concentration: 1.0
has only substance units: false
name: 2,5-dihydroxybenzoate
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_028c19d3_d1c1_4496_a69e_b78e5f650c2b
has only substance units: false
type: Species
initial concentration: NaN
name: ADSL
boundary condition: true
constant: false
is encoded by: hsa:158
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_aee57ea5_69a6_46ef_8463_a5db91b2412d
is encoded by: hsa:5295
boundary condition: true
initial amount: NaN
name: PIK3CA:PIK3R1
initial concentration: NaN
constant: false
is: SBO:0000297
has only substance units: false
type: Species
has part: P27986

http://identifiers.org/biomodels.db/MODEL1310110035#_a71348a9_e151_4ec5_b439_2d69ded25a20
is encoded by: hsa:5335
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PLCG1
initial amount: NaN
has only substance units: false
type: Species
is: Q9UFY1

metaR r1012
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: false
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:

metaR HSAT3ly
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM h c
type: Species
is: SBO:0000247
is: C00080
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
boundary condition: false
name: proton
initial amount: NaN
initial concentration: 1.0
constant: false

metaR PROt4
reversible: false
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
modifier: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: Na+/Proline-L symporter
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_c31b7b6f_975e_4173_b874_eb7ee92d4f52
has only substance units: false
type: Species
name: MTHFD2
is: SBO:0000252
is: P13995
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10797
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ae813a55_2594_46cd_8009_389b1176726f
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q53H96
name: PYCRL
type: Species
is encoded by: hsa:65263

metaR CORE4GTg
reactant: MODEL1310110035#
fast: false
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110035#
type: Reaction
is: SBO:0000176

metaR r1418
kinetic law: MODEL1310110035#
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#

metaM ser L e
is: CHEBI:17115
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00187
name: L-serine
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR S4TASE1ly
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#

metaR r0488
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is described by: ECO:0000000
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
product: MODEL1310110035#
fast: false

metaR r0921
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Postulated transport reaction
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_c4976493_3b41_4d1a_bddd_ad59b8a4f9b0
constant: false
initial amount: NaN
initial concentration: NaN
is: Q15111
is encoded by: hsa:5334
type: Species
is: SBO:0000252
name: PLCL1
has only substance units: false
boundary condition: true

metaR r1013
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
type: Reaction
product: MODEL1310110035#
name: Transport reaction
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#
reversible: false

metaM bildglcur r
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: CHEBI:58471
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB03325
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin

metaM din e
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN
constant: false
is: CHEBI:28997
is: HMDB00071
name: Deoxyinosine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4fd73569_10a5_45b0_9f2f_691a807d961d
name: DCTD
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: P32321
has only substance units: false
is encoded by: hsa:1635

metaR ATPtx
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110035#
name: ATP transporter, peroxisomal
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_f3b97242_c411_45a5_b817_da42ab16ddbb
boundary condition: true
name: PIGX:PIGM
has part: Q9H3S5
is encoded by: hsa:93183
type: Species
initial concentration: NaN
is: SBO:0000297
constant: false
has part: Q8TBF5
initial amount: NaN
has only substance units: false
is encoded by: hsa:54965

metaR EHGLATm
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
modifier: MODEL1310110035#
is described by: ECO:0000212
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_b6e2bab7_5f2b_4175_b304_f87a7c6b9a77
name: GALNT8
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9NY28
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:26290

http://identifiers.org/biomodels.db/MODEL1310110035#_8a9c7563_8472_4219_b0dd_4fe706cd2047
type: Species
constant: false
is encoded by: hsa:2629
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110035#_d2479ee7_dbfc_4935_923e_f05831a3db2a
initial amount: NaN
name: _BF195998_1_x
boundary condition: true
constant: false
is encoded by: hsa:BF195998
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM dcdp m
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
has only substance units: false
name: dCDP(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01245
constant: false
is: CHEBI:58593

metaR PIPLC
type: Reaction
reversible: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
name: phosphatidylinositol phospholipase C
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
modifier: MODEL1310110035#

metaR r1167
type: Reaction
name: EC:2.3.1.26
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: false
is described by: ECO:0000000

metaR r1014
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Postulated transport reaction
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_8ef503dc_1220_4645_b714_e6a1fb6e0d14
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84569
name: LYZL1
initial concentration: NaN
boundary condition: true
is: Q6UWQ5
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_aa503249_d341_46f9_ae05_bf2f52813d11
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:29920
name: PYCR2
is: Q96C36
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_af12da1e_8049_42cf_8bd7_47f5ba98865e
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8527
is: Q16760
initial amount: NaN
type: Species
is: SBO:0000252
name: DGKD
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9200b679_4e41_4d7d_818a_4c6b9c36f724
name: ALAS1
constant: false
is encoded by: hsa:211
initial amount: NaN
is: P13196
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR CYSSERNaEx
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110035#
reversible: false
product: MODEL1310110035#
is: SBO:0000185
type: Reaction

metaM crn m
type: Species
is: HMDB00062
has only substance units: false
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: CHEBI:16347
constant: false
is: C00318
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_40966150_bceb_4106_8205_557a1d3879b8
boundary condition: true
name: SLC27A2
is: O14975
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11001
constant: false

metaR G14T11g
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#

metaM dcdp n
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
name: dCDP(3-)
constant: false
has only substance units: false
is: HMDB01245
initial concentration: 1.0
boundary condition: false
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110035#_a14277cc_08c0_45c1_8ff0_d9e7f0f2c274
initial amount: NaN
is: SBO:0000252
name: SLC25A16
is: P16260
has only substance units: false
is encoded by: hsa:8034
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR r0060
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
type: Reaction
product: MODEL1310110035#

metaR S6TASE9ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110035#
is: SBO:0000176
reversible: true
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
fast: false
kinetic law: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM mi1p D c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02985
is: CHEBI:58433
boundary condition: false
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_8b6cb138_3a7f_49c5_b2c7_35f2956333b5
boundary condition: true
name: _D87002_1_e
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:D87002
is: SBO:0000252
type: Species
initial amount: NaN

metaM cs e deg7 l
has only substance units: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3
constant: false

metaR RE1518M
reactant: MODEL1310110035#
fast: false
name: RE1518
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM pppg9 c
is: CHEBI:57307
initial amount: NaN
is: C01079
constant: false
type: Species
has only substance units: false
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01097
name: Protoporphyrinogen IX

metaR LEUKTRD4t
kinetic law: MODEL1310110035#
name: leukotriene D4 transport
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110035#

metaM citr L m
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
is: CHEBI:16349
name: L-citrulline
has only substance units: false

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_313841b4_c73e_4f69_b905_0f71d5bbce35
type: Species
is encoded by: hsa:6563
boundary condition: true
name: SLC14A1
is: G0W2N5
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_cd9117ef_cdd0_4fb3_9263_e7e7e6cadfb8
constant: false
is encoded by: hsa:9091
has only substance units: false
is: SBO:0000252
name: PIGQ
initial amount: NaN
boundary condition: true
type: Species
is: Q9BRB3
initial concentration: NaN

metaR r2331
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GLNCYSNaEx
fast: false
is: SBO:0000185
reversible: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaM glyc3p x
is: SBO:0000247
type: Species
constant: false
is: HMDB00126
has only substance units: false
name: Glycerol 3-phosphate
initial concentration: 1.0
is: C00093
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597

metaR TETPENT6t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185

metaR PEROXx
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: peroxisomal lumped long chain fatty acid oxidation
reactant: MODEL1310110035#

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r2109
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_3def2b72_b8c4_47b1_89b8_6497f7f18846
type: Species
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _HG2846_HT2983_1_c
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_5e88cef6_ddae_41c4_91de_27b75dc24ea5
boundary condition: true
name: SULT2A1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6822
type: Species
is: Q06520

metaM vitd3 e
is: CHEBI:28940
is: HMDB00876
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
initial concentration: 1.0
type: Species
name: calciol
boundary condition: false

metaM h g
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton

metaR HEX10
is described by: ECO:0000212
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-glucosamine:ATP)
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

metaR ABTD
name: L-arabinitol 4-dehydrogenase
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#

metaM hdd2coa m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
is: HMDB03945
is: C05272
constant: false

metaR r2332
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaR NRPPHRSULT
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
name: Norepinephrine Sulfotransferase
modifier: MODEL1310110035#
reversible: false
product: MODEL1310110035#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0df6e1bc_625e_42a8_b685_5314cc85b2a9
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: ALDOA
is encoded by: hsa:226
constant: false

metaM 3hmp m
name: 3-hydroxy-2-methylpropanoate
is: CHEBI:11805
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial concentration: 1.0
is: HMDB00023
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaM crn e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: C00318
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: SBO:0000247
constant: false
is: CHEBI:16347
name: L-Carnitine

http://identifiers.org/biomodels.db/MODEL1310110035#_00756dcf_ebe4_44a8_8e9b_cb677a44e274
is: SBO:0000252
is encoded by: hsa:55907
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q8NFW8
name: CMAS
initial concentration: NaN

metaR r0339
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110035#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_032355e4_3c0f_488d_9d14_72e8ca6a4947
name: NOS1
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: B4DG68
is encoded by: hsa:4842
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_715769f1_02a8_4b66_b04f_b2a316022296
type: Species
has only substance units: false
is: SBO:0000252
is: Q9C0J1
name: B3GNT4
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79369
boundary condition: true

metaR FAOXC15NADx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nad)x
type: Reaction

metaR CYTK12n
product: MODEL1310110035#
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110035#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
is described by: ECO:0000269

metaR r1708
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185

metaR r2333
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_3dfe98ce_8236_4f36_b8f9_ae616337380b
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:NOS2A
boundary condition: true
initial amount: NaN
name: _NOS2A_1_c
is: SBO:0000252
type: Species

metaM retinol e
constant: false
is: SBO:0000247
name: retinol
initial amount: NaN
is: HMDB00305
is: CHEBI:50211
has only substance units: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
boundary condition: false
initial concentration: 1.0

metaR NACHEX17ly
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_52ea4258_2e73_4c03_b6b3_f8dc59fa3632
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O75355
has only substance units: false
initial amount: NaN
name: ENTPD3
constant: false
type: Species
is encoded by: hsa:956

http://identifiers.org/biomodels.db/MODEL1310110035#_b1fd8936_7ded_483f_9c40_1ed6fca2d7bb
is encoded by: hsa:8525
boundary condition: true
type: Species
constant: false
is: B7Z2M9
has only substance units: false
initial concentration: NaN
name: DGKZ
is: SBO:0000252
initial amount: NaN

metaR DGCHOLtx
kinetic law: MODEL1310110035#
name: bile acid intracellular transport
product: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reactant: MODEL1310110035#

metaM 2decdicoa m
has only substance units: false
type: Species
initial concentration: 1.0
name: 2,7-decadienoylcoa
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: CHEBI:28940
is: HMDB00876
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: calciol
boundary condition: false
has only substance units: false

metaR r1018
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR CSNAT3x
reactant: MODEL1310110035#
fast: false
type: Reaction
name: carnitine O-aceyltransferase, peroxisomal
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
reversible: true
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110035#

metaR LINOFATPtc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM h e
name: proton
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: C00080
is: CHEBI:24636
boundary condition: false

metaR RE0915E
reversible: true
name: RE0915
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_384f3611_d9b9_4155_9644_3a4435a2f02a
initial amount: NaN
is encoded by: hsa:10400
boundary condition: true
initial concentration: NaN
constant: false
name: PEMT
has only substance units: false
is: SBO:0000252
type: Species

metaR GBSIDEtl
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
product: MODEL1310110035#
fast: false
is: SBO:0000185
name: globoside intracellular transport
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#

metaR r2334
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_2af264f5_2083_4b48_b0e1_bf7dfec62f40
has only substance units: false
boundary condition: true
name: ETFB
is: P38117
initial concentration: NaN
constant: false
is encoded by: hsa:2109
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_0a40f711_2f4d_483d_ad29_c139eeb1315b
initial concentration: NaN
name: PIK3C2B
constant: false
is encoded by: hsa:5287
is: SBO:0000252
initial amount: NaN
is: O00750
type: Species
has only substance units: false
boundary condition: true

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR GLYt7 311 r
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000006
is: SBO:0000185
reversible: true

metaM o2s c
initial amount: NaN
is: CHEBI:18421
initial concentration: 1.0
boundary condition: false
is: HMDB02168
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_31489bc9_b443_4597_8856_6da03031f68d
constant: false
initial amount: NaN
name: PDE3A
is encoded by: hsa:5139
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q14432

metaR THRSERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
fast: false
product: MODEL1310110035#
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
is: SBO:0000185
reversible: false
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR r1019
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_e09c9feb_8432_4b97_aa33_ff593dafc32c
constant: false
is encoded by: hsa:6120
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: RPE
is: Q96AT9
initial concentration: NaN

metaR M16NTg
product: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.143
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaM CE5101 m
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57795
constant: false

metaR 4NPHSULT
is: SBO:0000176
type: Reaction
reversible: false
name: 4-Nitrophenol Sulfotransferase
fast: false
modifier: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM 5mthf c
boundary condition: false
is: CHEBI:3729
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0
is: C00440
is: SBO:0000247
is: HMDB01396
type: Species
name: 5-Methyltetrahydrofolate

metaM HC02213 e
is: CHEBI:28031
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaM xol7ah2 m
initial amount: NaN
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial concentration: 1.0
has only substance units: false
is: HMDB06893
constant: false

metaR FACOAL240
reversible: true
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110035#_48cb6691_9e80_4c7e_9add_8024385cde34
boundary condition: true
name: PANK2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q6P1K9
is encoded by: hsa:80025

metaM retn r
has only substance units: false
boundary condition: false
constant: false
name: all-trans-retinoate
initial amount: NaN
is: CHEBI:35291
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852

metaM 56dthm m
constant: false
name: 5,6-dihydrothymine
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: HMDB00079
has only substance units: false
is: CHEBI:27468
type: Species
initial concentration: 1.0

metaM acnam l
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: N-acetylneuraminate
boundary condition: false
has only substance units: false
is: CHEBI:35418

metaR URATEt
is: SBO:0000185
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_caf90716_7b9d_48a9_8e97_6b9a580c6b12
is encoded by: hsa:8310
initial amount: NaN
is: O15254
name: ACOX3
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM pram c
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58681
initial amount: NaN
name: 5-Phospho-beta-D-ribosylamine
is: HMDB01128
is: SBO:0000247
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: C03090

metaM Ser Thr g
is: HMDB00645
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
is: CHEBI:58336

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#

metaM crn x
type: Species
is: HMDB00062
is: C00318
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16347
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM 4hexdtetcoa x
boundary condition: false
is: SBO:0000247
type: Species
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM gtp c
is: SBO:0000247
is: HMDB01273
initial concentration: 1.0
initial amount: NaN
is: C00044
name: GTP
is: CHEBI:37565
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaR r0870
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.4
reactant: MODEL1310110035#
name: Facilitated diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.4.13
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR DOPAt4 2 r
modifier: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269

metaM 3mgcoa m
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial concentration: 1.0
has only substance units: false
is: HMDB01057
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57346
constant: false
type: Species
name: trans-3-methylglutaconyl-CoA(5-)

metaR NACHEX18ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110035#
reversible: false
type: Reaction

metaR PCRNtm
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is described by: ECO:0000000
name: transport into the mitochondria from cytosol (carnitine)

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
is: SBO:0000247
name: lipoamide
is: CHEBI:17460
boundary condition: false
has only substance units: false
type: Species
is: HMDB00962
constant: false
initial amount: NaN

metaR NAIt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is described by: ECO:0000269
name: Na+ / iodide cotransport
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_3212f0eb_8ab7_46d7_8758_50b5fe2d2483
is: P13807
type: Species
has only substance units: false
name: GYS1
is encoded by: hsa:2997
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR B3GNT35g
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110035#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false

metaM 5aop c
is: HMDB01149
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17549
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
name: 5-Amino-4-oxopentanoate

metaR SCP2x
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_0d0fd858_6ea9_41a8_841f_7919ba2774d2
is encoded by: hsa:4124
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: MAN2A1
type: Species
initial concentration: NaN
is: Q16706

metaM udpg c
name: UDPglucose
initial concentration: 1.0
boundary condition: false
is: CHEBI:58367
is: SBO:0000247
initial amount: NaN
is: C00029
is: HMDB00286
type: Species
has only substance units: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

http://identifiers.org/biomodels.db/MODEL1310110035#_11e6f40c_458b_47d7_92e2_237884032db3
has part: P37287
is encoded by: hsa:5277
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000297
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM C05965 e
boundary condition: false
is: HMDB04243
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
name: 12(S)-HPETE(1-)
is: CHEBI:57444
type: Species

metaR FACOAL2042
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_956cbc83_2f85_4f8b_bd36_e697639a062a
initial concentration: NaN
constant: false
name: ACAA1
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
boundary condition: true

metaM xoldiolone r
type: Species
is: CHEBI:28477
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR PPDOx
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM 2octdectecoa m
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 2,6,9,12-octadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110035#_b8f77809_2e23_46e3_9b7f_0d2dc8697767
constant: false
name: ALAS1
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q5JAM2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:211
type: Species

metaM acnam n
is: HMDB00230
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
type: Species
initial concentration: 1.0
name: N-acetylneuraminate
boundary condition: false
has only substance units: false
is: CHEBI:35418

metaM HC02213 c
is: SBO:0000247
name: prostaglandin-e3
is: CHEBI:28031
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR THMP
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
name: thiamin phosphatase

metaM gtp e
initial amount: NaN
boundary condition: false
name: GTP(4-)
initial concentration: 1.0
is: CHEBI:37565
has only substance units: false
is: SBO:0000247
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fc5bd968_6b03_4948_b917_5b1cbfde7d9e
initial amount: NaN
is: SBO:0000252
is: P48764
name: SLC9A3
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:6550

metaR FACOAL241
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110035#
type: Reaction

metaR IDPtn
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
name: IDP nuclear transport
reversible: true
type: Reaction

metaR PPDOy
fast: false
reversible: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110035#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269

metaR ARGtm
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
modifier: MODEL1310110035#
is: SBO:0000185
name: arginine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110035#

metaM thf c
constant: false
is: CHEBI:57453
is: HMDB01846
initial amount: NaN
type: Species
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false
initial concentration: 1.0
is: C00101
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false

metaR RE3242R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3242
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
fast: false
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000

metaM 34dhpac c
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
has only substance units: false
constant: false
name: 3,4-Dihydroxyphenylacetaldehyde
initial amount: NaN
boundary condition: false
is: CHEBI:27978
is: SBO:0000247
is: HMDB03791

metaM udpg e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58367
is: HMDB00286
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_34b7b321_7049_40c9_b75e_cbfcb098bee7
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5147
type: Species
initial amount: NaN
has part: O43924
has part: P18545
constant: false
is encoded by: hsa:5148
has only substance units: false
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9ff097e9_86db_48eb_a2bd_c57a031e881d
type: Species
name: EPX
initial concentration: NaN
is: P11678
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8288
initial amount: NaN
constant: false

metaR AMETr
name: S-Adenosyl-L-methionine intracellular diffusion
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110035#

metaM Rtotal3coa c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: R total 3 Coenzyme A
type: Species
is: HMDB01448
constant: false
boundary condition: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
is: CHEBI:16189

metaR ATPS4m
is version of: http://identifiers.org/ec-code/3.6.4.6
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
product: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.14
is described by: ECO:0000134
name: ATP synthase (four protons for one ATP)
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_a4fc705f_0f10_4747_b4ca_d513943430fe
is: SBO:0000252
type: Species
is: O75610
is encoded by: hsa:10637
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: LEFTY1
initial concentration: NaN

metaR AHCYStd
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
name: diffusion of S-Adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
is described by: ECO:0000134

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
constant: false
boundary condition: false
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR RE1532M
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1532
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
fast: false
type: Reaction

metaR r0722
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.3.12
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176

metaR GMPtn
reversible: true
kinetic law: MODEL1310110035#
fast: false
name: GMP nuclear transport
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_8dabdcec_9612_4180_8837_1c20154ac550
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AA177072_1_c
is encoded by: hsa:AA177072
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7cdec877_c1b7_49e6_b9b5_44ad0ca9a2e4
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q59FD4
initial amount: NaN
is: SBO:0000252
name: HK1
is encoded by: hsa:3098
type: Species

metaM 2dr5p c
is: CHEBI:57651
initial amount: NaN
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
has only substance units: false
boundary condition: false
constant: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR RE2069C
product: MODEL1310110035#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
name: RE2069

metaM dudp c
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01000
is: C01346
is: SBO:0000247
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
initial amount: NaN
has only substance units: false
name: dUDP

metaR S6T12g
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f6da46b7_e9bf_4590_9e76_3f9390492de4
initial amount: NaN
is encoded by: hsa:2679
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GGT3P

http://identifiers.org/biomodels.db/MODEL1310110035#_e0640cbd_c227_4083_98d5_65fb7e7aec1e
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC26A9
constant: false
is encoded by: hsa:115019
type: Species
is: Q7LBE3
initial concentration: NaN

metaR r2100
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
reversible: true

metaR r0721
reactant: MODEL1310110035#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110035#
is: SBO:0000176

metaR FUCASE2ly
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
name: alpha-fucosidase, lysosomal
fast: false

metaM thf e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: HMDB01846
boundary condition: false
is: CHEBI:57453

http://identifiers.org/biomodels.db/MODEL1310110035#_cb392041_868e_4b18_8817_505d379c1250
has only substance units: false
name: ADCY2
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:108
is: Q71UM8
type: Species

metaM cholcoa c
constant: false
boundary condition: false
initial concentration: 1.0
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: CHEBI:57373
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01374
initial amount: NaN

metaR C14STRr
name: C-14 sterol reductase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
fast: false

metaM 5mthf e
is: SBO:0000247
boundary condition: false
is: C00440
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
constant: false
is: CHEBI:3729
initial concentration: 1.0
type: Species
is: HMDB01396
has only substance units: false

metaR FACOAL2252
is described by: ECO:0000269
reactant: MODEL1310110035#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110035#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_acd08062_f8e1_4898_8ff1_cfcc0cefbbb4
is: SBO:0000252
is: Q13123
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:3550
initial concentration: NaN
name: IK

metaR CYSGLTH
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Glutathione:cystine oxidoreductase
fast: false
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM

http://identifiers.org/biomodels.db/MODEL1310110035#_67506c51_541a_4472_838f_7774641c5d78
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: SLC27A3
is encoded by: hsa:11000
boundary condition: true
is: Q5K4L6
type: Species

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_1131074a_2050_4f75_a303_8e4947d12972
type: Species
boundary condition: true
is encoded by: hsa:275
is: P48728
constant: false
is: SBO:0000252
has only substance units: false
name: AMT
initial amount: NaN
initial concentration: NaN

metaR FAOXC163x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_f9470bf1_8b64_4ea4_b72d_e82d888df5e5
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: HAO2
is encoded by: hsa:51179
initial concentration: NaN
boundary condition: true

metaR FACOAL2251
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
kinetic law: MODEL1310110035#
reversible: true

metaR r0509
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
product: MODEL1310110035#
is: SBO:0000176

metaR LEUTAm
type: Reaction
is described by: ECO:0000269
name: leucine transaminase, mitochondrial
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110035#

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_cbc05333_5895_436d_ab1d_84b773249e09
initial amount: NaN
constant: false
is encoded by: hsa:4645
type: Species
is: SBO:0000252
has only substance units: false
name: MYO5B
initial concentration: NaN
boundary condition: true
is: Q9H6Y6

metaR LACZe
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.108
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: b-galactosidase, extracellular
fast: false
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110035#

metaR PTE4x
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
kinetic law: MODEL1310110035#
name: peroxisomal acyl-CoA thioesterase
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
reversible: false

metaR HEXDICOAACBPx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR S6T5g
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_09b37754_57d9_4b17_90bf_659ea808bb63
name: DGKQ
constant: false
initial amount: NaN
is encoded by: hsa:1609
has only substance units: false
initial concentration: NaN
is: P52824
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_1813a671_b477_4baa_9c0a_1537cb3f80a1
name: SLC12A5
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q9H2X9
constant: false
is: SBO:0000252
is encoded by: hsa:57468
initial concentration: NaN

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
modifier: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110035#

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0e68ecd1_de9f_4d2a_a173_c7bde7bfd57b
name: MAOB
is encoded by: hsa:4129
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: P27338
initial concentration: NaN
constant: false
is: SBO:0000252

metaR GLCAASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000269
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110035#
type: Reaction

metaM 5aop m
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17549
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
is: HMDB01149
is: C00430
initial concentration: 1.0
type: Species
name: 5-Amino-4-oxopentanoate

metaR FAOXC12C10m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM xylu L c
is: HMDB00751
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17399
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
name: L-xylulose
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_2169e3ad_170b_4be0_8ac2_9f8ba33cb61a
name: GGT2
initial amount: NaN
is encoded by: hsa:728441
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR DM atp c
product: MODEL1310110035#
reversible: false
name: DM_atp(c)
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000134

metaR ANTHte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000134
name: Transport of anthranilate
is: SBO:0000185

metaR DURAD2
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: dihydrothymin dehydrogenase (NADP)
kinetic law: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
is: SBO:0000176

metaR r2104
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR AHCYStr
reactant: MODEL1310110035#
fast: false
name: S-Adenosyl-L-homocysteine intracellular diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_83f3654c_3ee3_4e6d_ba65_d08e31a9c044
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM caro e
type: Species
constant: false
initial amount: NaN
is: CHEBI:17579
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00561
name: beta-carotene
initial concentration: 1.0
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR CSEPASEly
reversible: false
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaM f1a l
is: HMDB02917
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17151
type: Species
name: F1alpha
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false

metaR GAO1g
name: Ganglioside O-acetylation
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110035#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_bf99b2ea_4fc9_4481_813d_3ad9d01c0295
type: Species
name: SLC7A2
is encoded by: hsa:6542
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P52569
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_cb41f842_3bcd_45a0_8e23_628232705b4e
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q9BW60
name: ELOVL1
is encoded by: hsa:64834

metaR HSD17B2r
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.62
reactant: MODEL1310110035#
name: 17-beta-hydroxysteroid dehydrogenase
modifier: MODEL1310110035#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f378ff51_4b31_45f5_9406_f515c53e8648
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:48
name: ACO1
type: Species
has only substance units: false
is: P21399

http://identifiers.org/biomodels.db/MODEL1310110035#_15b7e656_0a0a_4c24_b74f_705c1f70a17d
initial amount: NaN
name: ALG12
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79087
is: Q9BV10
type: Species

metaR FAOXC185m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaM thymd c
name: Thymidine
is: C00214
has only substance units: false
is: CHEBI:17748
initial concentration: 1.0
initial amount: NaN
is: HMDB00273
is: SBO:0000247
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
constant: false

metaR r2101
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#
fast: false

metaR TAURt4 2 r
fast: false
is: SBO:0000185
name: taurine transport (sodium symport) (2:1)
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
type: Reaction
product: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaR SMS
fast: false
reactant: MODEL1310110035#
name: Sphingomyelin synthase (homo sapiens)
modifier: MODEL1310110035#
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.8.27

http://identifiers.org/biomodels.db/MODEL1310110035#_1cccabc0_7613_474a_9523_a7e0df5d8a5a
boundary condition: true
is: P80404
is: SBO:0000252
type: Species
is encoded by: hsa:18
name: ABAT
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c569439a_3f96_4e8a_8e7f_4f85ac9901d9
is encoded by: hsa:412
boundary condition: true
initial amount: NaN
name: STS
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110035#_90714f89_fa4e_45a8_a671_8d039ec85195
type: Species
is: B7Z3U6
name: ATP1A1
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:476

metaR NACHEX26ly
kinetic law: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110035#
product: MODEL1310110035#

metaR FAOXTC102C101m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM cs a deg3 l
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
type: Species
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3

metaR G14T10g
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM caro c
is: HMDB00561
type: Species
constant: false
initial amount: NaN
is: CHEBI:17579
has only substance units: false
boundary condition: false
is: SBO:0000247
name: beta-carotene
initial concentration: 1.0
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094

metaR 4MOPte
fast: false
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185

metaM ksi deg24 l
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: CHEBI:12936
type: Species
boundary condition: false
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 24

metaR r2102
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110035#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_365d606c_b023_4b95_9f39_4ad003928c80
type: Species
is encoded by: hsa:3632
is: Q14642
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: INPP5A
has only substance units: false
is: SBO:0000252

metaR NDP3ex
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
fast: false
reactant: MODEL1310110035#
name: nucleoside-diphosphatase (GDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
type: Reaction

metaR TETPENT3COAtx
reversible: true
product: MODEL1310110035#
type: Reaction
name: fatty acid intracellular transport
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM fald c
name: formaldehyde
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB01426
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

http://identifiers.org/biomodels.db/MODEL1310110035#_02f14d86_3d7c_4b5e_aabb_2ab85aa546ab
initial amount: NaN
name: _AI697028_1_e
has only substance units: false
constant: false
is encoded by: hsa:AI697028
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaM HC00900 c
name: Methylmalonate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
is: CHEBI:30860
is: SBO:0000247
initial amount: NaN

metaR ADRNCOAtx
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR S4TASE4ly
product: MODEL1310110035#
modifier: MODEL1310110035#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12

metaM btamp c
is: HMDB04220
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
boundary condition: false
is: CHEBI:3110
name: Biotinyl-5'-AMP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_e4d3a174_edce_4b5b_b48f_3b2838b77132
type: Species
initial concentration: NaN
is encoded by: hsa:51302
has only substance units: false
boundary condition: true
is: SBO:0000252
name: CYP39A1
initial amount: NaN
constant: false
is: Q9NYL5

http://identifiers.org/biomodels.db/MODEL1310110035#_a37f19ac_1be0_42bc_aed0_9b111a458679
is encoded by: hsa:217
initial amount: NaN
boundary condition: true
name: ALDH2
has only substance units: false
is: SBO:0000252
is: P05091
constant: false
initial concentration: NaN
type: Species

metaR RE2996X
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.1.34
type: Reaction
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110035#
is: SBO:0000176
name: RE2996

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e7d8ec6e_1a65_4464_a543_e9b9de207ea3
is encoded by: hsa:7296
is: SBO:0000252
is: Q16881
initial amount: NaN
name: TXNRD1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_57690d3d_2711_406b_b91c_90350bac43f8
initial amount: NaN
is encoded by: hsa:2582
type: Species
name: GALE
is: SBO:0000252
is: Q14376
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR FUMSO3tm
fast: false
name: Fumarate:sulfite antiport, mitochondrial
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000269
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110035#_10965a27_9bb2_45c1_8b7a_52b55542feee
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27034
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q6ZWP6
name: ACAD8

metaR r2107
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false

metaR UMPK
reversible: true
is described by: ECO:0000269
name: UMP kinase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_8307f827_42a1_4a75_88e5_a93d3c4fb947
type: Species
name: ATP5D
has only substance units: false
is encoded by: hsa:513
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaM 3hpcoa m
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial amount: NaN
is: CHEBI:58528
boundary condition: false
constant: false
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species

metaM CE0849 m
has only substance units: false
boundary condition: false
name: cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
is: CHEBI:57795
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_9994c960_02b8_46af_8dfc_69782b3f2664
constant: false
boundary condition: true
is encoded by: hsa:2997
type: Species
has part: P13807
is: SBO:0000297
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: GYG1:GYS1

metaM m4masn g
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C05881
constant: false
type: Species
notes: FORMULA: C46H77N2O35X CHARGE: 0
is: SBO:0000247

metaR AMETt2m
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
modifier: MODEL1310110035#
reversible: true
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_300977e7_c2ed_405f_bbe2_72778cd070c9
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:6555
type: Species
name: SLC10A2
initial amount: NaN
has only substance units: false
is: Q12908
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_33ab90b9_95ec_49bb_8b2e_4949f607c609
type: Species
is: P43166
is: SBO:0000252
is encoded by: hsa:766
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: CA7

metaM doco13ecoa x
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_2ced83f6_84eb_46c6_847f_63a282b87052
constant: false
is: Q92911
boundary condition: true
has only substance units: false
is encoded by: hsa:6528
name: SLC5A5
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9c48aaa0_debf_4fdf_ac9d_dee66242fd35
has only substance units: false
constant: false
boundary condition: true
is: Q59EA4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: PLD1
is encoded by: hsa:5337

metaR r2108
reactant: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_fa0b75a8_07cd_4a84_884e_050efcb7f8de
is encoded by: hsa:50808
constant: false
name: AK3
initial amount: NaN
is: E7ET30
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR SUCCTD
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM succoa m
constant: false
is: SBO:0000247
has only substance units: false
name: Succinyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: CHEBI:57292
boundary condition: false
is: HMDB01022
type: Species

metaR ICDHyrm
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110035#
is: SBO:0000176
name: Isocitrate dehydrogenase (NADP+)

http://identifiers.org/biomodels.db/MODEL1310110035#_26c6afca_fb03_4a9f_9b7c_0f62ee3621ac
initial amount: NaN
is encoded by: hsa:5631
name: PRPS1
has only substance units: false
initial concentration: NaN
is: P60891
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
name: Malate:sulfate antiport, mitochondrial
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaR FUMm
product: MODEL1310110035#
name: fumarase, mitochondrial
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.2

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR NH4t3r
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: ammonia transport via proton antiport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110035#

metaR r2105
is: SBO:0000185
kinetic law: MODEL1310110035#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_e7e5cab4_059b_4ef5_9ea7_d2dba1d78731
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SHMT1
is encoded by: hsa:6470

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
boundary condition: false
type: Species
constant: false
is: CHEBI:28766
initial concentration: 1.0
name: UroporphyrinogenI
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR AG13T1g
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_05c2643b_cf3e_4573_ac7f_6e32f5e3152a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10327
has only substance units: false
constant: false
is: P14550
initial amount: NaN
boundary condition: true
type: Species
name: AKR1A1

metaR RTOTAL2t
fast: false
product: MODEL1310110035#
reversible: true
is: SBO:0000185
name: RTOTAL2 transport
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_71dae49e_0d01_4e71_a1eb_0187508ba06b
initial concentration: NaN
is encoded by: hsa:9154
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: SLC28A1
has only substance units: false
is: Q96PL7
is: SBO:0000252

metaR BAAT1x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
fast: false
product: MODEL1310110035#
is: SBO:0000176
reversible: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110035#_c4c38a8c_5e1d_4ecc_96f2_c66c5364c964
boundary condition: true
is: Q01959
has only substance units: false
is encoded by: hsa:6531
is: SBO:0000252
name: SLC6A3
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c3924ee2_f58b_49ae_9c69_98b55e2fbe23
name: ACP1
constant: false
initial concentration: NaN
is encoded by: hsa:52
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q59EH3
has only substance units: false

metaR PEPCKm
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176

metaR GMPtg
reversible: true
fast: false
reactant: MODEL1310110035#
name: GMP transport (Golgi)
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110035#

metaR TYRCBOX
kinetic law: MODEL1310110035#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Tyrosine carboxy-lyase
reversible: false
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110035#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM cs a l
type: Species
is: HMDB02183
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36005
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: SBO:0000247
initial amount: NaN

metaR ABO6g
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
product: MODEL1310110035#

metaR VALTA
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
reversible: true
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#

metaM crn r
is: HMDB00062
is: CHEBI:16347
type: Species
is: SBO:0000247
constant: false
boundary condition: false
name: (R)-carnitine
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0

metaR THYOXt
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110035#

metaR 2HBt2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#

metaR FACOAL184
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#

metaR r2106
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110035#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR VLCSp
is described by: ECO:0000269
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b4cc3bbe_4b09_45a0_b54b_47f174255956
constant: false
is: SBO:0000252
is encoded by: hsa:518
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ATP5G3
type: Species

metaR BILIRED
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110035#
name: Nad(p)h biliverdin reductase
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7904ed91_212c_4fb4_ae1d_bbdb14ecd03d
type: Species
boundary condition: true
is: P05062
name: ALDOB
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:229
has only substance units: false
is: SBO:0000252
constant: false

metaM CE5236 n
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_ed2a346d_b25e_46de_960c_b393d4b427b8
is: SBO:0000252
is encoded by: hsa:957
type: Species
initial amount: NaN
has only substance units: false
is: O75356
initial concentration: NaN
boundary condition: true
constant: false
name: ENTPD5

metaR CORE3GTg
fast: false
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaR DGTPtn
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: dGTP diffusion in nucleus
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
fast: false

metaR RE1898C
fast: false
is: SBO:0000176
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r0410
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
is: SBO:0000176
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is described by: ECO:0000000

metaR OCCOAtx
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is: SBO:0000185
name: fatty acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110035#

metaM duri m
constant: false
is: HMDB00012
name: 2'-deoxyuridine
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450

http://identifiers.org/biomodels.db/MODEL1310110035#_3b717987_ae81_4716_87e6_cd39011c23ea
name: SLC4A2
has only substance units: false
is encoded by: hsa:6522
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: F8W682
boundary condition: true
constant: false

metaM cholcoa x
has only substance units: false
type: Species
is: HMDB01374
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
is: CHEBI:57373

metaM oh1 c
is: C01328
constant: false
is: HMDB01039
name: hydroxide ion
is: SBO:0000247
type: Species
notes: FORMULA: HO CHARGE: -1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR FACOAL191
modifier: MODEL1310110035#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
name: fatty-acid--CoA ligase

metaR MI13PP
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
reactant: MODEL1310110035#
reversible: false
name: inositol-1,3-bisphosphate 3-phosphatase
fast: false
is described by: ECO:0000000

metaM dd2coa m
is: SBO:0000247
type: Species
is: HMDB03712
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: trans-dodec-2-enoyl-CoA(4-)
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
is: CHEBI:57330

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR DGTPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110035#
reversible: false
product: MODEL1310110035#
name: transport of dGTP into mitochondria
kinetic law: MODEL1310110035#
is: SBO:0000185

metaM succoa x
is: HMDB01022
initial concentration: 1.0
is: SBO:0000247
name: Succinyl-CoA
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110035#_909ece55_34b0_4379_95ac_3df50680e5c2
name: PANK2
boundary condition: true
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_4c69eb82_d3b6_4706_8dfd_1591e6d2529a
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: DPYSL3
is: Q8IXW6
is encoded by: hsa:1809
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fb28267d_eb30_4e75_bea1_4de0d17b8444
initial concentration: NaN
is encoded by: hsa:1962
boundary condition: true
is: SBO:0000252
is: Q9NY65
name: EHHADH
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM prpp e
is: CHEBI:58017
boundary condition: false
initial concentration: 1.0
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR MANt1r
modifier: MODEL1310110035#
name: mannose transport (uniport)
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaR S6TASE17ly
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110035#
type: Reaction

metaM oh1 e
boundary condition: false
is: HMDB01039
is: SBO:0000247
type: Species
name: hydroxide ion
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
is: C01328
has only substance units: false
initial concentration: 1.0
constant: false

metaM dhcholestanate r
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
has only substance units: false
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
is: CHEBI:16577
is: HMDB00359
boundary condition: false
initial amount: NaN

metaM Lcystin c
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
is: CHEBI:16283
constant: false
is: HMDB00192
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: L-cystine

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
is: CHEBI:61648
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_508fa783_1837_4c99_bb28_1577fdde1175
initial concentration: NaN
is encoded by: hsa:2194
has only substance units: false
is: SBO:0000252
type: Species
name: FASN
boundary condition: true
constant: false
is: P49327
initial amount: NaN

metaR FAOXC163GC142m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM hmbil c
has only substance units: false
name: Hydroxymethylbilane
is: CHEBI:57845
is: C01024
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01137

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: butyrate
initial concentration: 1.0
is: CHEBI:17968
initial amount: NaN
has only substance units: false

metaM dhcrm hs c
initial concentration: 1.0
is: CHEBI:31488
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: dihydroceramide
has only substance units: false
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

http://identifiers.org/biomodels.db/MODEL1310110035#_12a98c06_bd16_4fb1_8d8d_da699a632169
is encoded by: hsa:482
constant: false
initial amount: NaN
name: ATP1B2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: P14415

http://identifiers.org/biomodels.db/MODEL1310110035#_5c3652d7_0fe9_4df7_b3e5_70d054646459
constant: false
initial amount: NaN
is: E2QRH8
initial concentration: NaN
type: Species
is encoded by: hsa:5332
boundary condition: true
name: PLCB4
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_2bdc3ed5_f453_46db_aed8_c1c90f2e02c5
constant: false
name: MGAM
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8972
is: SBO:0000252
is: O43451
has only substance units: false
initial amount: NaN

metaM duri n
name: 2'-deoxyuridine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00012
type: Species
boundary condition: false
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial concentration: 1.0

metaR CSNAT2x
fast: false
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7

metaR FAOXC103C102m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM ksii core4 deg3 l
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3
constant: false
has only substance units: false
initial concentration: 1.0

metaR CYTDtm
modifier: MODEL1310110035#
type: Reaction
name: cytidine facilated transport in mitochondria
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#

metaM cspg e l
has only substance units: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
is: HMDB02183
initial concentration: 1.0
type: Species
is: CHEBI:36005
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_bf979c0e_8a1a_4ffb_87fa_3296ce2c8593
initial concentration: NaN
has only substance units: false
is: Q9H3H5
is encoded by: hsa:1798
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: DPAGT1
boundary condition: true

metaR FATP9t
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110035#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR RE1342C
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110035#
is: SBO:0000176
fast: false
name: RE1342
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaM ksi deg13 l
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: HMDB00812
has only substance units: false
is: CHEBI:16953
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 13

metaR ACHtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000185
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9275c3ab_5113_4c97_a061_94e13b67cef1
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5283
name: PIGH
is: Q14442
initial concentration: NaN

metaM core2 g
name: Core 2
has only substance units: false
type: Species
is: CHEBI:15876
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
boundary condition: false
initial amount: NaN

metaR THYMt
is: SBO:0000185
product: MODEL1310110035#
fast: false
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
name: thymine reversible transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#

metaM retinal cis 13 r
has only substance units: false
initial concentration: 1.0
is: HMDB06220
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: SBO:0000247
name: 13-cis-retinal
boundary condition: false
is: CHEBI:45487
initial amount: NaN
type: Species
constant: false

metaM 3hexdtetcoa m
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02288
constant: false
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa

metaR HSPGtly
fast: false
name: heparan sulfate transport, extracellular to lysosome
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR CYSGLUexR
fast: false
is described by: ECO:0000304
modifier: MODEL1310110035#
is: SBO:0000185
name: L-cysteine/L-glutamine reversible exchanger
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#

metaM Lcystin e
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
is: CHEBI:16283
constant: false
type: Species
is: SBO:0000247
is: HMDB00192
initial amount: NaN
name: L-cystine
boundary condition: false
initial concentration: 1.0

metaR RDH1a
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)
fast: false
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300

metaR BPNT
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
fast: false
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.7
is described by: ECO:0000269
name: 3',5'-bisphosphate nucleotidase

metaM q10 c
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01072
name: ubiquinone-10
type: Species

metaR FADtx
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
reversible: true
name: FAD transporter, peroxisomal
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction

metaM acgpail hs c
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57265

metaR DNDPt22m
modifier: MODEL1310110035#
name: dTDP transport via dUDP antiport
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110035#
is described by: ECO:0000269
fast: false
product: MODEL1310110035#
is: SBO:0000185

metaR GTMLTe
is described by: ECO:0000269
name: g-glutamyltransferase (e)
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
is: SBO:0000185
fast: false
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110035#

metaR 34HPPOR
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.13.11.27
product: MODEL1310110035#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7d6ec064_1065_4095_aad2_69d99c10f1b7
boundary condition: true
is encoded by: hsa:3418
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: IDH2
is: SBO:0000252
constant: false
is: P48735
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_55079924_cab2_45a5_8781_af5675ca255b
boundary condition: true
initial concentration: NaN
is encoded by: hsa:83715
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: ESPN
is: B1AK53
has only substance units: false

metaR CYOR u10m
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110035#
name: ubiquinol-6 cytochrome c reductase, Complex III
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110035#_4d91385f_a473_4bc5_9f8c_1572d98a50dc
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: PIGC
is encoded by: hsa:5279
initial amount: NaN
has only substance units: false
constant: false

metaR AG13T16g
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_d111b8d5_ac9b_4b90_953b_ca5a965d451b
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:10841
name: FTCD
boundary condition: true
is: O95954
initial amount: NaN
is: SBO:0000252

metaR ASNCYSNaEx
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: false
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110035#
type: Reaction

metaR LALDO
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.1
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

metaR VLCSr
is: SBO:0000176
product: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
name: Very-long-chain-fatty-acid-CoA ligase
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false

metaR NCKt
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is: SBO:0000185
reversible: true
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM dhcholestanate m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00359
boundary condition: false
is: CHEBI:16577
has only substance units: false
constant: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaR OIVD2m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is: SBO:0000176
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_46dfe9a1_54c3_4e5c_a5cc_9aff982e494e
initial amount: NaN
name: OGDH
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q02218
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110035#_847ded64_54ec_4379_b269_2f7e4a288775
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: B4DNK4
is: SBO:0000252
name: PKM2
has only substance units: false
is encoded by: hsa:5315

metaR DM anth
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR UGALNACtg
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110035#
name: UDP-GalNAc Golgi transport via CMP antiport
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reactant: MODEL1310110035#

metaM hs deg7 l
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
name: heparan sulfate, degradation product 7
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB06210

metaR r0308
is described by: ECO:0000000
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
is: SBO:0000176
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
kinetic law: MODEL1310110035#
type: Reaction

metaR PRGNLONESULT
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.14
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.2
fast: false
name: steroid sulfotransferase
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
type: Reaction
reversible: false
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f5798e1a_798e_44fb_8407_9f6558011b94
is: P07451
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: CA3
type: Species
is encoded by: hsa:761
boundary condition: true

metaR FAOXC2442246x
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110035#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110035#
name: Beta oxidation of long chain fatty acid

metaM 56dthm c
constant: false
name: 5,6-dihydrothymine
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: HMDB00079
is: CHEBI:27468
has only substance units: false
type: Species
initial concentration: 1.0

metaM q10 e
name: ubiquinone-10
is: CHEBI:46245
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
initial concentration: 1.0
is: HMDB01072
has only substance units: false
type: Species

metaR MM7B2g
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000000
product: MODEL1310110035#
modifier: MODEL1310110035#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR r0655
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
modifier: MODEL1310110035#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10

MODEL1310110035#
species: metaM ksi pre16 g
species: metaM mal L e
species: metaM HC00695 m
species: metaM uacgam g
species: metaM hedepecoa m
stoichiometry: 0.153018
species: metaM sphs1p r
species: metaM fuc1p L c
species: metaM strdnc c
species: metaM dcsptn1coa c
species: metaM andrstandn r
species: metaM leugly e
species: metaM core4 g
species: metaM biocyt c
species: metaM apoC m
species: metaM nadph x
species: metaM xylu D c
species: metaM ksi pre21 g
species: metaM ptth c
species: metaM btamp m
species: metaM leuktrD4 c
species: metaM 5dhf e
species: metaM 10fthf7glu e
name: PIK3CD:PIK3R1
name: DPM3:DPM1:DPM2
species: metaM dhlam m
species: metaM pro D c
species: metaM accoa c
species: metaM ppa c
species: metaM Ssq23epx r
species: metaM ksi pre4 g
species: metaM ksi deg24 l
species: metaM 3mb2coa m
species: metaM vitd3 c
species: metaM glc D r
species: metaM duri m
species: metaM HC01007 c
species: metaM ncam e
name: PIK3CA:PIK3R3
species: metaM 3hpp m
species: metaM dtdp n
species: metaM paps c
species: metaM nrpphr c
species: metaM adrncoa c
species: metaM 35cgmp n
species: metaM dmhptcrn e
species: metaM ha e
species: metaM pi e
species: metaM thcholstoic m
species: metaM 4nphsf c
species: metaM hx2coa x
species: metaM pail5p hs n
species: metaM HC01115 c
name: ACAA1:HSD17B4:ACOX1
species: metaM m5mpdol L r
species: metaM btn e
stoichiometry: 14.0
species: metaM pail34p hs c
species: metaM tethex3coa x
species: metaM Rtotalcoa c
species: metaM anth c
species: metaM nrvnccoa c
species: metaM ksi pre13 g
species: metaM ksi pre22 g
species: metaM retinal cis 13 r
species: metaM 44mzym r
species: metaM dolglcp L r
species: metaM em2emgacpail hs r
species: metaM succ m
species: metaM pcrn c
species: metaM prgstrn e
species: metaM sbt D c
species: metaM 12ppd R c
species: metaM spmd c
species: metaM 5adtststerone e
species: metaM pcrn m
species: metaM 3mob c
species: metaM ksi pre27 g
species: metaM lac L e
species: metaM lys L m

metaR r1177
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
reversible: false
is: SBO:0000176
fast: false
name: EC:3.1.1.13

metaR RE3074X
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110035#
fast: false
reversible: true
reactant: MODEL1310110035#
is: SBO:0000176
name: RE3074
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000

metaR S6T6g
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM 3uib c
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
has only substance units: false
constant: false
name: 3-Ureidoisobutyrate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02031
is: CHEBI:1670

http://identifiers.org/biomodels.db/MODEL1310110035#_1d4b5901_b0a5_4366_b364_26e79fcc5cb3
name: GGT1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: P19440
is: SBO:0000252
is encoded by: hsa:2678
boundary condition: true
type: Species

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110035#_0924e745_6bd9_46e3_b24b_ed356f086aba
name: BDH1
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:622

metaM doco13ecoa c
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892791
is: SBO:0000247
has only substance units: false
name: 13-docosenoylcoa
boundary condition: false
constant: false

metaM acnam c
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:35418
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
constant: false
initial amount: NaN
type: Species
name: N-acetylneuraminate

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaR TALA
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false
name: transaldolase
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2

http://identifiers.org/biomodels.db/MODEL1310110035#_67d7ddfd_9936_4ab5_b87d_a75e2382e453
is: SBO:0000252
is encoded by: hsa:81579
has only substance units: false
name: PLA2G12A
initial amount: NaN
type: Species
is: Q542Y6
boundary condition: true
constant: false
initial concentration: NaN

metaM 1glyc hs e
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
is: HMDB00972
name: 1 acyl phosphoglycerol

http://identifiers.org/biomodels.db/MODEL1310110035#_5cc72eaa_a203_4412_a1e1_a4a3f0bc131b
name: PANK2
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:80025
has only substance units: false
is: Q6P1K9
initial concentration: NaN
constant: false
initial amount: NaN

metaR FE3MTP1
is described by: ECO:0000134
reactant: MODEL1310110035#
name: transport of ferrous iron into blood
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000185

metaR P45011A1m
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.15.6
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
product: MODEL1310110035#
type: Reaction
reversible: false
name: Cytochrome P450 11A1, mitochondrial [Precursor]

metaR r0726
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176

metaR MOGAT
kinetic law: MODEL1310110035#
name: monoacylglycerol acyltransferase
notes: GENE_ASSOCIATION: (116255.1) or (80168.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.22
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_890dceaf_1b49_4200_b111_85dea3322984
name: SLC25A10
initial concentration: NaN
is: Q9UBX3
is encoded by: hsa:1468
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_103f1b37_206c_404b_9648_f30c99976cf5
initial concentration: NaN
name: PTS
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5805
is: Q03393
boundary condition: true
is: SBO:0000252

metaM gtp m
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:37565
is: HMDB01273
is: C00044
boundary condition: false
has only substance units: false
name: GTP
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaM thm c
is: C00378
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
notes: FORMULA: C12H17N4OS CHARGE: 1
has only substance units: false
name: Thiamin
is: SBO:0000247
type: Species
is: HMDB00235
constant: false
initial amount: NaN

metaM f6p c
boundary condition: false
initial amount: NaN
name: D-Fructose 6-phosphate
initial concentration: 1.0
is: CHEBI:57579
is: SBO:0000247
type: Species
is: HMDB00124
is: http://identifiers.org/pubchem.compound/3385
has only substance units: false
is: C00085
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e710b7de_8d75_485e_a692_3fc4d8a9213d
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:81537
has only substance units: false
name: SGPP1
is: Q9BX95
boundary condition: true
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7cc4730a_385e_4e0a_877a_1af49fd41ff2
constant: false
is encoded by: hsa:80347
name: COASY
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q13057
type: Species

metaR r0653
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110035#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM duri c
type: Species
initial concentration: 1.0
is: CHEBI:16450
is: SBO:0000247
boundary condition: false
constant: false
is: C00526
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
initial amount: NaN
is: HMDB00012

http://identifiers.org/biomodels.db/MODEL1310110035#_5080bbcc_7454_4b9d_a857_4120eba76008
is encoded by: hsa:AL050025
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: _AL050025_1_c
is: SBO:0000252

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM udpgal e
initial amount: NaN
is: CHEBI:58439
type: Species
is: HMDB00302
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
constant: false
name: UDP-D-galactose(2-)

metaR r0723
is: SBO:0000176
reversible: false
modifier: MODEL1310110035#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_07aac343_add5_4e8f_b957_cc4206db0a24
name: FOLR1
initial amount: NaN
is encoded by: hsa:2348
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaM gtp n
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: GTP(4-)
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
is: CHEBI:37565
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1f3a92b8_5b2b_4974_a7ba_0dbf09215a5a
is encoded by: hsa:W74642
initial amount: NaN
constant: false
has only substance units: false
name: _W74642_1_c
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR FACOAL244 1
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_3a058737_d088_4d37_8b87_56be676d3c5a
boundary condition: true
constant: false
has only substance units: false
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR r0650
is described by: ECO:0000000
reversible: true
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:

metaR FBP
kinetic law: MODEL1310110035#
name: fructose-bisphosphatase
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP

metaR FAOXC160
product: MODEL1310110035#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_1c32a506_e722_4f96_b251_bf8c0d26c7bd
is encoded by: hsa:123041
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q8NFF2
type: Species
boundary condition: true
name: SLC24A4

metaR FAOXC80
modifier: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of med/long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110035#_5f20e2ff_d25e_4f99_a20b_ca82c4d7b95e
type: Species
name: SDR16C5
boundary condition: true
initial amount: NaN
is encoded by: hsa:195814
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: B3KT84

http://identifiers.org/biomodels.db/MODEL1310110035#_9aaa10db_1021_4225_b8da_a15e5f8500d4
is encoded by: hsa:55293
has only substance units: false
initial amount: NaN
is: Q8IX04
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: UEVLD

http://identifiers.org/biomodels.db/MODEL1310110035#_9ccb0c85_7dec_453d_a3b6_b1b30e6c3c98
type: Species
is encoded by: hsa:HG2846-HT2983
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _HG2846_HT2983_1_m
initial amount: NaN

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaR r0724
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110035#

metaM dd2coa x
name: trans-Dodec-2-enoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
initial amount: NaN
is: HMDB03712
is: CHEBI:57330
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

metaM duri e
constant: false
name: Deoxyuridine
is: HMDB00012
boundary condition: false
is: CHEBI:16450
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
initial amount: NaN
is: SBO:0000247
is: C00526

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2

metaM btamp m
constant: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
has only substance units: false
boundary condition: false
type: Species
name: Biotinyl-5'-AMP
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:3110

metaM udpgal c
is: HMDB00302
name: UDP-D-galactose(2-)
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58439
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_442f767b_e17a_4504_837c_6274275d66c7
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: NDUFB5
is: O43674
has only substance units: false
initial amount: NaN
is encoded by: hsa:4711
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_350b6d2d_c2f6_4a40_8f7b_2ebaff64dda1
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:7378
name: UPP1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_84779d4e_1046_4845_a904_74c03b666f11
constant: false
name: CYP1B1
is: Q16678
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1545
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d9d4af74_0abe_48f7_bd59_570c1e6a4a93
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:80025
boundary condition: true
is: SBO:0000252
name: PANK2
has only substance units: false

metaM udpgal g
name: UDP-D-galactose(2-)
type: Species
is: HMDB00302
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58439

metaR r0729
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_c4212802_675c_4c7e_9e0b_2278b97fe30d
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
constant: false
is: SBO:0000252

metaM dhcholestanate c
is: CHEBI:16577
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00359
type: Species
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

http://identifiers.org/biomodels.db/MODEL1310110035#_fabdd753_6f81_4d4d_8628_a52c1d4860f5
has only substance units: false
type: Species
is encoded by: hsa:10246
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: O00624
is: SBO:0000252
name: SLC17A2

metaM prpp c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00119
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00280
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: CHEBI:58017

http://identifiers.org/biomodels.db/MODEL1310110035#_d4172251_8ca1_455b_873b_b3bc9a9966d0
constant: false
is: SBO:0000252
is: P13073
type: Species
initial concentration: NaN
is encoded by: hsa:1327
boundary condition: true
initial amount: NaN
has only substance units: false
name: COX4I1

metaM 12ppd R c
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01881
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial concentration: 1.0
name: (R)-propane-1,2-diol
is: CHEBI:28972
boundary condition: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM hs deg25 l
notes: FORMULA: C23H37O21 CHARGE: -1
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16126
type: Species
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaM HC00900 m
is: CHEBI:30860
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
constant: false
type: Species
is: SBO:0000247
name: Methylmalonate
boundary condition: false
initial concentration: 1.0

metaR NACHEX10ly
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110035#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0504
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110035#

metaR BTND1
name: biotinidase (biotin)
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.1.12
product: MODEL1310110035#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM but c
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00039
is: CHEBI:17968
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d55b3409_8c8f_4840_8a62_e93730c43a8e
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: _U37519_1_c
initial amount: NaN
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110035#_28dfc2ce_6ef4_49f9_8f81_8cb1fd46003a
boundary condition: true
constant: false
initial concentration: NaN
is: P23109
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:270
name: AMPD1

metaR ADCim
name: Acetoacetate decarboxylation (irreversible), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM hx2coa m
has only substance units: false
name: trans-Hex-2-enoyl-CoA
constant: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB13037
is: SBO:0000247
is: C00888

http://identifiers.org/biomodels.db/MODEL1310110035#_138836bd_e173_4e9e_8453_0efb8a419bd1
has only substance units: false
is: P52789
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: HK2
is encoded by: hsa:3099
initial concentration: NaN
initial amount: NaN

metaM g3pc c
is: HMDB00086
initial concentration: 1.0
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
boundary condition: false
is: CHEBI:16870
initial amount: NaN
type: Species
name: sn-Glycero-3-phosphocholine
is: SBO:0000247
has only substance units: false
constant: false

metaM Asn X Ser Thr r
is: CHEBI:28938
notes: FORMULA: XH CHARGE: 0
constant: false
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
is: SBO:0000247
has only substance units: false
is: C01342
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR HSAT2ly
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185

metaM cspg e e
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
is: HMDB00300
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial concentration: 1.0
type: Species
is: C00106
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:17568

metaR r0727
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110035#
reversible: false
fast: false
is: SBO:0000176

metaR FADH2tru
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
is: SBO:0000185
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110035#
fast: false
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaR GLCURtly
kinetic law: MODEL1310110035#
name: glucuronate transport into lysososme
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
product: MODEL1310110035#
reversible: true
fast: false
is: SBO:0000185

metaR MANter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
name: mannose efflux from endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4d470858_d13f_4c05_9813_c2559c6b73b4
name: DPAGT1
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:1798
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_430cd42e_fa42_4066_a227_c2a1236f9196
constant: false
name: ENTPD2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q5SPY7
is encoded by: hsa:954

http://identifiers.org/biomodels.db/MODEL1310110035#_8b0be06c_a414_4ad9_a82e_7e25d2a1081f
has only substance units: false
name: PEMT
type: Species
is encoded by: hsa:10400
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR DPCOAPPe
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
name: Pyrophasphatase (dephospho-CoA, extracellular)
product: MODEL1310110035#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_c795910f_d256_4b02_91d8_d80b6a7e274b
initial amount: NaN
name: ACADL
initial concentration: NaN
is: P28330
type: Species
is encoded by: hsa:33
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_8ce192c1_56ce_4513_b5e8_78440dfa5593
has only substance units: false
is: Q3MHC9
initial concentration: NaN
is encoded by: hsa:23517
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: SKIV2L2
type: Species

metaR URIDK2m
reversible: true
is described by: ECO:0000134
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
fast: false
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_6de3c7ce_a525_4511_af0e_11eb6d9615ae
initial amount: NaN
constant: false
is encoded by: hsa:94005
boundary condition: true
type: Species
initial concentration: NaN
name: PIGS
has only substance units: false
is: Q8NBL9
is: SBO:0000252

metaR r0502
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.113
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110035#
fast: false

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_ee23270c_7e58_44c7_a19b_20546fe22046
boundary condition: true
name: ETFA
constant: false
has only substance units: false
initial concentration: NaN
is: P13804
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:2108

metaR CYTDK2m
kinetic law: MODEL1310110035#
name: cytidine kinase (ATP), mitochondrial
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
reactant: MODEL1310110035#

metaM 4hexdtetcoa m
is: HMDB02288
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
name: 4,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_84f30d6b_86df_4e54_b9a5_375bfd1e6122
initial concentration: NaN
is: Q9NVE7
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: PANK4
has only substance units: false
is encoded by: hsa:55229

metaR LPS
type: Reaction
name: lipase
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.34
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_33ecfa25_81f5_457a_b5a7_c722a858874d
is: SBO:0000252
constant: false
initial amount: NaN
name: GPX4
initial concentration: NaN
type: Species
is encoded by: hsa:2879
boundary condition: true
has only substance units: false
is: P36969

http://identifiers.org/biomodels.db/MODEL1310110035#_fc80d78e_936b_4210_8c00_25e35f4a5d31
constant: false
boundary condition: true
is encoded by: hsa:115286
name: SLC25A26
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR RE1526M
type: Reaction
product: MODEL1310110035#
name: RE1526
is described by: ECO:0000000
modifier: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaM q10 m
is: HMDB01072
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: ubiquinone-10
boundary condition: false
constant: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR LPS4e
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false
is described by: ECO:0000000

metaR UPPN
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269
reactant: MODEL1310110035#
is: SBO:0000176
name: b-ureidopropionase
fast: false
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
product: MODEL1310110035#
modifier: MODEL1310110035#

metaR ALAt2r
kinetic law: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
product: MODEL1310110035#
name: L-alanine reversible transport via proton symport
type: Reaction
reversible: true
reactant: MODEL1310110035#
modifier: MODEL1310110035#

metaM ksi pre24 g
initial concentration: 1.0
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
constant: false
name: keratan sulfate I biosynthesis, precursor 24
has only substance units: false
boundary condition: false
is: CHEBI:58053
initial amount: NaN
is: C00130
is: SBO:0000247
type: Species
is: HMDB00175

metaM 4mop c
is: CHEBI:17865
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695

metaR r0881
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
reversible: false
fast: false
product: MODEL1310110035#

metaR DADAe
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000176
type: Reaction
name: Deoxyadenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false

metaM Lkynr c
is: CHEBI:16946
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00684
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
name: L-kynurenine

metaM gly m
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
boundary condition: false
is: C00037
initial concentration: 1.0
type: Species
is: HMDB00123
is: SBO:0000247

metaR RE1531M
reactant: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1531
is described by: ECO:0000000
product: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110035#

metaR r1298
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1f483a82_75f4_4ac7_9d90_ec89b3a35e31
is: Q3KT79
type: Species
constant: false
boundary condition: true
is encoded by: hsa:23600
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: AMACR

http://identifiers.org/biomodels.db/MODEL1310110035#_de29798a_be3e_47f7_af4b_d50d0a92e8d8
boundary condition: true
is encoded by: hsa:5150
initial concentration: NaN
initial amount: NaN
is: Q13946
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: PDE7A

metaR IDOAASE4ly
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110035#
type: Reaction
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:58216
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: sphingomyelin betaine

http://identifiers.org/biomodels.db/MODEL1310110035#_d9c293c9_6e15_4069_9744_61c5bc4f9199
boundary condition: true
constant: false
name: B3GALT5
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10317
initial concentration: NaN
is: SBO:0000252

metaM utp m
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
boundary condition: false
is: HMDB00285
constant: false
type: Species
is: SBO:0000247
is: CHEBI:46398
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM glyc m
name: Glycerol
is: HMDB00131
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:17754
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110035#_27286878_d4ba_45ec_bb3f_47d547e7b6a5
is: SBO:0000297
constant: false
boundary condition: true
is encoded by: hsa:10870
type: Species
has part: P48736
initial amount: NaN
is encoded by: hsa:5294
has only substance units: false
initial concentration: NaN
name: HCST:PIK3CG
has part: Q9UBK5

metaR PI34P5K
reversible: false
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110035#
type: Reaction

metaM acgam l
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
type: Species
has only substance units: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_f7dae84b_b2f0_413a_a8b9_48da32ab3dec
boundary condition: true
is: B7Z5G2
initial concentration: NaN
constant: false
is encoded by: hsa:2629
is: SBO:0000252
has only substance units: false
name: GBA
initial amount: NaN
type: Species

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
reversible: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r1299
fast: false
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110035#
name: Vesicular transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_763fe553_04e0_413c_a14e_149d42dfbde7
initial amount: NaN
has only substance units: false
is encoded by: hsa:3295
boundary condition: true
initial concentration: NaN
constant: false
has part: E9PB82
name: ACAA1:HSD17B4:ACOX1
is: SBO:0000297
type: Species

metaR S6T11g
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR RE3000M
reactant: MODEL1310110035#
name: RE3000
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false

metaR r0517
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false

metaR B3GNT36g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_be64a9cf_1e43_49ee_a114_b40071ffa6e5
is: SBO:0000252
is encoded by: hsa:AA526438
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: _AA526438_1_c

http://identifiers.org/biomodels.db/MODEL1310110035#_df2b4e98_011f_44f6_8be2_ebfc6d885108
boundary condition: true
is encoded by: hsa:645
is: P30043
initial amount: NaN
name: BLVRB
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM HC02216 c
has only substance units: false
boundary condition: false
initial amount: NaN
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
is: CHEBI:28922
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR PHEACGLNt
type: Reaction
name: PHEACGLN extracellular transport via diffusion
fast: false
product: MODEL1310110035#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
reactant: MODEL1310110035#

metaR ORNt3m
type: Reaction
name: ornithine mitochondrial transport via proton antiport
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110035#

metaR INSt5le
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110035#
name: inosine transport in via sodium (1:2) symport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FAOXC103C102x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR FE2tm
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: iron (II) transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.

metaR LPCHOLt
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: lysophosphatidylcholine transport
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
product: MODEL1310110035#

metaR r0730
reversible: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
type: Reaction

metaR ASPTAm
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
name: aspartate transaminase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM 2octpencoa m
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
name: 2,6,9,12,15-octadecapentenoylcoa
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species

metaR CYSASNNaEx
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110035#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_ed77d4f8_377e_4d87_b051_9d8f62408821
boundary condition: true
has only substance units: false
name: CA12
constant: false
is: SBO:0000252
is encoded by: hsa:771
initial concentration: NaN
type: Species
initial amount: NaN

metaM sphmyln hs g
has only substance units: false
constant: false
is: CHEBI:58216
type: Species
name: sphingomyelin betaine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247

metaR FAOXC101C8m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR G12MT2 L
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
reactant: MODEL1310110035#
reversible: false
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_65c8d11b_cbb8_4b85_b533_870639482995
name: PPCDC
has only substance units: false
initial amount: NaN
is encoded by: hsa:60490
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q96CD2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_83b53170_cf06_4f98_9988_43863c9c5b5d
constant: false
is encoded by: hsa:79053
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: ALG8
is: Q9BVK2
initial amount: NaN
boundary condition: true

metaR GLCAASE7ly
kinetic law: MODEL1310110035#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
name: beta-glucuronidase, lysosomal
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_f03f1e28_7c6d_4e69_9e5c_70749bf20ebd
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: NT5C1B
is encoded by: hsa:93034
is: B3KUK6
initial concentration: NaN

metaR LEULEULAPc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_dc969e74_d068_4fc4_b44a_9783f6672578
is: SBO:0000252
is encoded by: hsa:204
initial amount: NaN
type: Species
name: AK2
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM dolmanp L c
initial amount: NaN
boundary condition: false
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15809
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR SIAT9g
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
type: Reaction

metaM oxa c
constant: false
is: CHEBI:30623
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0
name: oxalate(2-)
type: Species
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR FUM
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
name: fumarase
reversible: true
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.2

metaR RE3241R
reactant: MODEL1310110035#
name: RE3241
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#

metaR LYStm
name: Lysine mitochondrial transport via ornithine carrier
reversible: true
product: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaM malcoa r
name: malonyl-CoA(4-)
initial amount: NaN
constant: false
is: CHEBI:57384
is: HMDB01175
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083

W3 CDTF: Fri Aug 31 04:53:45 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110035#_5fc6d381_61d4_4a6d_994a_cd10396cdbb1
boundary condition: true
name: PLCZ1
is encoded by: hsa:89869
is: Q86YW0
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR GALASE19ly
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000269
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is: SBO:0000176

metaM 3mop e
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
has only substance units: false
initial concentration: 1.0

metaM dxtrn c
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})
notes: FORMULA: C48H81O41X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02135
is: CHEBI:15748
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00127
type: Species
has only substance units: false

metaR INSTt4
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
product: MODEL1310110035#
reversible: true
fast: false
name: inositol transport via sodium symport
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000269
kinetic law: MODEL1310110035#

metaM HC01496 m
initial amount: NaN
name: 2-Amino-3-oxoadipate
boundary condition: false
initial concentration: 1.0
is: CHEBI:28095
has only substance units: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4e23b0ed_cef6_4b49_b478_73fe044f832f
type: Species
initial concentration: NaN
is: P48448
is: SBO:0000252
is encoded by: hsa:222
boundary condition: true
name: ALDH3B2
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_3458fba5_8c1f_41ef_90a5_657a60cf8a4b
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3948
name: LDHC
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_513e8c64_b1a4_4602_bc3c_989d26b823c0
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8503
boundary condition: true
is: SBO:0000252
name: PIK3R3
is: Q92569

http://identifiers.org/biomodels.db/MODEL1310110035#_0c200614_f40f_46c3_8cf0_a065f6e4764c
initial concentration: NaN
is: F5GWS5
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: ADCY10
is encoded by: hsa:55811
is: SBO:0000252

metaR r0732
kinetic law: MODEL1310110035#
fast: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
reversible: false
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reactant: MODEL1310110035#

metaR RE1135C
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
name: RE1135
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_98326213_6c94_4504_9974_82aeff853fb3
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:522
is: Q6IB54
constant: false
initial concentration: NaN
type: Species
name: ATP5J
boundary condition: true

metaM 1pyr5c m
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01301
initial concentration: 1.0
is: C03912

W3 CDTF: Fri Aug 31 04:53:45 BST 2012

metaR TYRt
fast: false
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: L-tyrosine transport
is: SBO:0000185
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110035#

metaM ksi pre1 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 1
notes: FORMULA: C79H129N5O57X CHARGE: -1
constant: false
is: C00130
is: HMDB00175
initial amount: NaN
has only substance units: false
is: CHEBI:58053
type: Species
boundary condition: false
is: SBO:0000247

metaR DNDPt38m
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: dUTP transport via dUDP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110035#
type: Reaction
fast: false
reactant: MODEL1310110035#

metaR CSNAT2m
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM dcacoa x
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
is: C05274
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: HMDB06404
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_321677ce_e1ce_486f_b5f1_55c24d0a55ad
constant: false
is: SBO:0000252
is: Q96QD8
name: SLC38A2
is encoded by: hsa:54407
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaR O2St
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
name: superoxide anion transport via diffusion (extracellular)
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR r2392
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110035#
is described by: ECO:0000000

metaM 2hb c
type: Species
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
is: CHEBI:1148
initial amount: NaN
initial concentration: 1.0
is: HMDB00008
boundary condition: false
constant: false
name: 2-Hydroxybutyrate

metaM CE4790 m
constant: false
initial concentration: 1.0
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
boundary condition: false
type: Species
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA

metaR r0731
is described by: ECO:0000000
type: Reaction
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110035#
fast: false

metaM oxa e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
type: Species
has only substance units: false
name: oxalate(2-)
is: SBO:0000247
is: HMDB02329
is: CHEBI:30623
constant: false

metaR LGNCt
fast: false
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110035#

W3 CDTF: Fri Aug 31 04:53:45 BST 2012

metaM pyr c
boundary condition: false
has only substance units: false
is: HMDB00243
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1
initial concentration: 1.0
is: CHEBI:15361
is: C00022
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324

metaR ADK1
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
name: adenylate kinase
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110035#
name: alcohol dehydrogenase (D-1,2-propanediol)

http://identifiers.org/biomodels.db/MODEL1310110035#_76ce0d86_a0db_4620_beb1_ff4393fbb196
is: P43007
name: SLC1A4
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6509
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_2031d0f1_7f26_4d86_b67e_1f2469b14026
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: _BG035985_1_c
initial concentration: NaN
is encoded by: hsa:BG035985

metaM HC00229 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
initial concentration: 1.0
name: Isomaltose
boundary condition: false
type: Species
is: CHEBI:28189

metaM 3mop c
is: CHEBI:28654
is: SBO:0000247
boundary condition: false
is: HMDB00491
initial amount: NaN
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
type: Species
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_ce91570a_a562_4c2a_b081_f10c92ffce44
constant: false
is: P21439
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5244
initial amount: NaN
name: ABCB4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1fa3fe9c_5988_4c86_b59e_44242ec0ae24
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2589
name: GALNT1
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q10472

metaR TAUPAT1c
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaM CE5126 x
name: (2R)-pristanoyl-CoA
is: CHEBI:12947
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaR CHAT
reversible: true
name: Choline O-acetyltransferase
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110035#
fast: false
type: Reaction

metaR r0734
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#

metaR FAOXC184m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR M13N2Tg
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110035#
reversible: false
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_7a1a6d3d_4a53_492b_9912_4c175c86519f
has only substance units: false
name: FOLR1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2348
initial concentration: NaN
type: Species

W3 CDTF: Fri Aug 31 04:53:45 BST 2012

metaR NACHEX27ly
kinetic law: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
product: MODEL1310110035#

metaR GALASE12ly
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM 2maacoa m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
constant: false
boundary condition: false
name: 2-methylacetoacetyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
is: HMDB01157
is: CHEBI:57335
type: Species

metaR F6Tg
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: glycoprotein 6-alpha-L-fucosyltransferase
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.68
modifier: MODEL1310110035#

metaR r0208
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
modifier: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.1

http://identifiers.org/biomodels.db/MODEL1310110035#_b5c4036c_ae30_44b6_86f5_34e9733a4538
name: COX3
boundary condition: true
has only substance units: false
is encoded by: hsa:4514
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: P00414

metaR r2394
fast: false
is: SBO:0000185
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_708c6e39_3b4a_45fb_b4cf_8e460219a41a
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6783
constant: false
type: Species
is: SBO:0000252
is: P49888
boundary condition: true
initial amount: NaN
name: SULT1E1

http://identifiers.org/biomodels.db/MODEL1310110035#_e5cb3977_19b9_4e52_a05f_b5cf5ab0595d
initial amount: NaN
name: PDE8B
initial concentration: NaN
is encoded by: hsa:8622
is: O95263
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR r0733
reversible: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110035#
fast: false
is described by: ECO:0000000
type: Reaction
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_24574645_7778_476b_b7ce_1726a3477da1
initial concentration: NaN
is encoded by: hsa:7378
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q16831
boundary condition: true
name: UPP1
is: SBO:0000252

metaR XOLTRIOLtm
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR ADK3
reversible: true
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
name: adentylate kinase (GTP)
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
fast: false

metaM 3decdicoa x
has only substance units: false
name: 3,7-decadienoylcoa
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN

metaR S6T4g
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110035#

metaM glyc c
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: C00116
is: CHEBI:17754
name: Glycerol
is: HMDB00131

metaM dcacoa m
constant: false
is: C05274
has only substance units: false
is: CHEBI:61430
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: HMDB06404
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
initial amount: NaN

metaM 3otdcoa x
initial amount: NaN
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
type: Species
is: HMDB03935
is: CHEBI:28726
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM gly e
name: Glycine
is: HMDB00123
initial amount: NaN
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3339
constant: false
is: C00037

metaM pyr e
has only substance units: false
is: CHEBI:15361
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
name: pyruvate
boundary condition: false
initial concentration: 1.0
is: HMDB00243

metaR DOLMANP Lter
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reversible: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r0202
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM malcoa e
name: malonyl-CoA(4-)
constant: false
initial concentration: 1.0
is: CHEBI:57384
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175

http://identifiers.org/biomodels.db/MODEL1310110035#_df070307_6ced_44d7_a922_91f32a16e28d
name: SLC5A3
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6526
initial amount: NaN
boundary condition: true
is: P53794

http://identifiers.org/biomodels.db/MODEL1310110035#_ebcbdd73_6558_4ce6_9e56_c1e84f36afa1
type: Species
constant: false
is: Q99643
is encoded by: hsa:6391
name: SDHC
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_2b9a2471_2d8f_467f_a2a5_4136c495b6a6
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1545
is: Q16678
boundary condition: true
name: CYP1B1
initial concentration: NaN
is: SBO:0000252
constant: false

metaR RE1573M
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
name: RE1573
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/5.3.3.8

http://identifiers.org/biomodels.db/MODEL1310110035#_6e219c68_be87_4619_9b2d_030f9a989bee
initial amount: NaN
is: SBO:0000252
name: ALDH1A1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P00352
constant: false
is encoded by: hsa:216
type: Species

metaM 5aizc c
constant: false
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: SBO:0000247
boundary condition: false
is: HMDB06273
is: C04751
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58564
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751

metaM glyc e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: C00116
is: HMDB00131
is: CHEBI:17754
name: Glycerol

metaR AG13T2g
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110035#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
fast: false

metaM ksi deg21 l
name: keratan sulfate I, degradation product 21
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: HMDB00143
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110035#_d61b61f2_4073_4ca1_bea9_56b8065c2ae4
constant: false
type: Species
is: Q96AS2
is encoded by: hsa:427
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ASAH1
boundary condition: true
initial concentration: NaN

metaR FAS180COA
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C18:0CoA)
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR AACOAT
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
product: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Acetoacetyl-CoA:acetate CoA-transferase
type: Reaction
fast: false

metaR OCT11EFATP
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM ppbng c
is: SBO:0000247
name: Porphobilinogen
initial concentration: 1.0
type: Species
is: HMDB00245
boundary condition: false
is: C00931
is: CHEBI:58126
constant: false
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_56a5b374_7334_464e_9e98_f476cc51eb4d
type: Species
is encoded by: hsa:LOC728997
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _LOC728997_1_c
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_194aa052_489e_4e43_8bfd_80e274e84e6b
name: _AV727634_1_c
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AV727634
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaM 2hb e
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
type: Species
boundary condition: false
has only substance units: false
name: 2-Hydroxybutyrate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:1148

metaM malcoa c
is: HMDB01175
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
boundary condition: false
is: C00083
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: Malonyl-CoA
has only substance units: false

metaM srtn e
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
is: CHEBI:350546
is: HMDB00259
initial amount: NaN
has only substance units: false
name: serotonin(1+)

http://identifiers.org/biomodels.db/MODEL1310110035#_b1f29f14_83be_4f07_a9eb_7cde212746aa
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: Q8TDB8
initial concentration: NaN
is encoded by: hsa:144195
is: SBO:0000252
name: SLC2A14

metaR FBA
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000134
name: fructose-bisphosphate aldolase
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaR CYOOm3
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110035#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185

metaM acgam r
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
type: Species
name: N-acetyl-D-glucosamine
is: HMDB00215
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_cef52c67_a312_4c91_81bb_18ae1ce33cc8
initial concentration: NaN
name: ST8SIA1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q92185
is encoded by: hsa:6489
initial amount: NaN

metaR OIVD1m
fast: false
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.168
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110035#
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR r0885
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction

metaR LNLCCPT2
type: Reaction
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110035#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_bcc3a762_2065_4a6d_8cbc_c28156af3331
is encoded by: hsa:51022
initial amount: NaN
name: GLRX2
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM oxa m
initial amount: NaN
type: Species
is: CHEBI:30623
has only substance units: false
is: HMDB02329
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
constant: false
is: SBO:0000247
name: oxalate(2-)

metaR RNDR1
name: ribonucleoside-diphosphate reductase (ADP)
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
is described by: ECO:0000254
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR LNLCCPT1
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e16c39fe_29e5_4748_966b_a540e650f491
boundary condition: true
type: Species
is: SBO:0000252
name: RHAG
is: Q96E98
constant: false
is encoded by: hsa:6005
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_e85ab324_26b9_491c_9f60_6f21d5ff87f9
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: LGALS13
is: Q9UHV8
is encoded by: hsa:29124
constant: false

metaR PHACCOAGLNAC
is: SBO:0000176
product: MODEL1310110035#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reactant: MODEL1310110035#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR r0940
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: Free diffusion
reactant: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#

metaM hyptaur c
is: SBO:0000247
constant: false
name: Hypotaurine
is: CHEBI:16668
type: Species
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial amount: NaN
has only substance units: false
is: HMDB00965
initial concentration: 1.0

metaR PSDm hs
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.1.1.65
name: Phosphatidylserine decarboxylase
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_0da29437_9e13_46ea_95f1_1c52421d5399
boundary condition: true
initial concentration: NaN
name: NUDT12
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q9BQG2
type: Species
is encoded by: hsa:83594

http://identifiers.org/biomodels.db/MODEL1310110035#_d4f81fa6_a114_4015_8c6e_297d8768573d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5152
name: PDE9A
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_0393ee2a_ce3e_4610_b8b5_0c47f852b98d
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: ST3GAL1
is encoded by: hsa:6482
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR MALSO3tm
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true

metaM 4mop e
constant: false
initial amount: NaN
is: CHEBI:17865
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00695
name: 4-methyl-2-oxopentanoate

metaM gly c
constant: false
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Glycine
is: CHEBI:3339
is: HMDB00123

metaM 2docohexecoa m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
constant: false
type: Species
name: 2,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790

metaR G14Tg
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#

metaR RTOTAL3t
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: RTOTAL3 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110035#
type: Reaction
fast: false
product: MODEL1310110035#
reversible: true

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM utp n
is: CHEBI:46398
is: SBO:0000247
name: UTP(4-)
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
constant: false
initial amount: NaN
is: HMDB00285
initial concentration: 1.0
has only substance units: false

metaR TMDK1
name: thymidine kinase (ATP:thymidine)
type: Reaction
modifier: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.21
is described by: ECO:0000269

metaM HC02216 e
initial concentration: 1.0
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28922
has only substance units: false
is: SBO:0000247

metaR THFtm
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000

metaR ABO7g
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
type: Reaction
kinetic law: MODEL1310110035#

metaM HC01602 c
initial amount: NaN
is: C00234
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
name: 10-Formyltetrahydrofolate
is: CHEBI:57454

metaR FACOAL170
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
name: fatty-acid--CoA ligase
fast: false
reversible: true
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaM 1pyr5c c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01301
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: SBO:0000247
is: C03912
has only substance units: false
type: Species

metaR NTD1m
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110035#
name: 5'-nucleotidase (dUMP),mitochondrial
reversible: false
modifier: MODEL1310110035#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM ksii core4 e
has only substance units: false
is: CHEBI:17268
initial amount: NaN
is: HMDB00211
name: keratan sulfate II (core 4-linked)
type: Species
boundary condition: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR CEPTE
name: ethanolamine phosphotransferase
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM 6dhf e
initial concentration: 1.0
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: hexaglutamyl folate (DHF)
is: SBO:0000247
has only substance units: false
is: HMDB06563

metaM CE5586 c
constant: false
initial amount: NaN
is: CHEBI:58732
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

http://identifiers.org/biomodels.db/MODEL1310110035#_c39feefb_84d7_4382_8b80_4c87a8693e81
initial amount: NaN
is: Q59GJ6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4524
name: MTHFR
has only substance units: false
constant: false

metaR B3GNT310g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaR ACGAMPM
is: SBO:0000176
kinetic law: MODEL1310110035#
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_66249ee1_2e13_4f58_b5b2_2ccfc5aed600
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:53905
is: SBO:0000252
name: DUOX1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_eaf74446_400a_46a2_b8b7_e890cacb4a4c
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2222
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: P37268
name: FDFT1

metaR r0941
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
fast: false
name: Free diffusion
reversible: true

metaR PAIL HStn
fast: false
product: MODEL1310110035#
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reversible: true

metaR RETFAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
reversible: false
name: fatty acid retinol efflux

metaM pep m
initial concentration: 1.0
is: HMDB00263
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021
is: SBO:0000247
boundary condition: false
name: Phosphoenolpyruvate
has only substance units: false
is: C00074

metaM pyr m
name: pyruvate
type: Species
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15361
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
has only substance units: false
is: HMDB00243

metaM dgsn c
initial concentration: 1.0
name: Deoxyguanosine
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17172
constant: false
is: HMDB00085
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330

metaM ksi pre13 g
is: SBO:0000247
has only substance units: false
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 13
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58053
constant: false
type: Species
notes: FORMULA: C143H231N10O111S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_e8e9c37e_bf16_4b10_b2db_002e82a3b6d8
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6576
name: SLC25A1
is: SBO:0000252
boundary condition: true
constant: false
is: D9HTE9
initial concentration: NaN

metaM gbside hs e
name: globoside
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:18259
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR DNDPt23m
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: dTDP transport via dGTP antiport

metaR r0942
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reversible: true
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaR FRDPtc
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
reversible: true
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110035#_26020f30_03c9_4a4b_9f75_b813886fb5e6
is encoded by: hsa:130
name: ADH6
boundary condition: true
initial concentration: NaN
type: Species
is: P28332
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM 4abutn e
has only substance units: false
name: 4-ammoniobutanal
type: Species
is: CHEBI:58264
constant: false
is: HMDB01080
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0

metaR AMPtp
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: AMP transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#

metaR r0317
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110035#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
reversible: true
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_34630f22_6f42_4e4e_88a0_81cbb4a8d23c
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: AKR1C1
is: Q04828
constant: false
has only substance units: false
is encoded by: hsa:1645
initial amount: NaN

metaR AG13T15g
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_bf4e06f6_532f_4005_9024_530b786b7599
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P78542
name: HK1
is encoded by: hsa:3098

http://identifiers.org/biomodels.db/MODEL1310110035#_f9ccef7d_d243_4671_9c20_3b618dfa962f
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2632
type: Species
is: Q04446
constant: false
has only substance units: false
initial concentration: NaN
name: GBE1

metaR LEUKTRF4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
name: leukotriene F4 transport
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
fast: false

metaR RE1516M
type: Reaction
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_b34d3fd2_bc87_4610_b815_be38451e41c8
boundary condition: true
is encoded by: hsa:AU149534
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: _AU149534_1_m
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_36ca2eab_c23d_4064_9bc5_e61b9d8de26b
is encoded by: hsa:2629
is: P04062
name: GBA
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9f2ede50_bb1b_40a3_859e_5e1cd0414e86
is: SBO:0000252
is: P43251
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:686
type: Species
name: BTD
has only substance units: false
constant: false

metaM 3decdicoa m
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: L-gulonate 3-dehydrogenase
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_cb038551_b054_46c6_9411_78a1c71312a7
name: RDH12
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q96NR8
is encoded by: hsa:145226
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_e27d23c7_9bb9_474b_a7df_05cc42173653
name: NME1
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4830
has only substance units: false

metaR r0423
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110035#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_a147690f_e915_44fc_80ce_dcd95c569dfc
type: Species
constant: false
initial concentration: NaN
name: _AI440329_1_r
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI440329
boundary condition: true
initial amount: NaN

metaR ACOAD10m
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176

metaR PRFGS
modifier: MODEL1310110035#
name: phosphoribosylformylglycinamidine synthase
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.3
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110035#

metaM dgsn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: Deoxyguanosine
is: CHEBI:17172
constant: false
has only substance units: false
boundary condition: false
is: HMDB00085
is: C00330

metaR ADK3m
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110035#
fast: false
name: adentylate kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.10

metaR G5SADrm
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaM gbside hs c
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:18259
is: SBO:0000247
type: Species
name: globoside
initial amount: NaN

metaR PPItx
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Diphosphate transporter, peroxisome
reversible: true
type: Reaction

metaR r0944
name: Active transport
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_d589976b_6bb5_4f1b_9bc6_661981aeaf3e
type: Species
initial amount: NaN
has only substance units: false
is: Q9BYZ2
is encoded by: hsa:92483
is: SBO:0000252
boundary condition: true
constant: false
name: LDHAL6B
initial concentration: NaN

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
constant: false
has only substance units: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
name: sphingosylphosphorylcholine
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaR H2Otly
is: SBO:0000185
name: H2O transport, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
fast: false
reactant: MODEL1310110035#
type: Reaction

metaR APAT2rm
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110035#
reversible: true
type: Reaction
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM lys L c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
initial amount: NaN
name: L-lysinium(1+)
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110035#_05886632_bfcc_4997_8c0d_27938cd9e1b5
is: Q6FGQ4
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: PPT1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5538

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_78cfb877_a58c_49a0_9e08_9cc86a1d3c50
has only substance units: false
type: Species
constant: false
name: ATP5E
initial concentration: NaN
is: SBO:0000252
is: P56381
boundary condition: true
initial amount: NaN
is encoded by: hsa:514

metaR RE1897C
is: SBO:0000176
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
product: MODEL1310110035#
name: RE1897

http://identifiers.org/biomodels.db/MODEL1310110035#_70092b1c_f603_4aa3_9744_68f1c0d29c51
has part: B4DP47
type: Species
is encoded by: hsa:1629
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000297
has part: P11182
has only substance units: false
is encoded by: hsa:593
has part: P21953
name: DBT:DLD:BCKDHA:BCKDHB
is encoded by: hsa:594

metaR FATP8t
is: SBO:0000185
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
product: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
fast: false
name: fatty acid electroneutral transport

metaR THYMDtm
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
name: thymd transport
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
type: Reaction
reversible: true

metaR r0666
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is described by: ECO:0000000
type: Reaction

metaM srtn c
is: HMDB00259
name: serotonin(1+)
constant: false
has only substance units: false
is: CHEBI:350546
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00972
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:57454
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9ee4de36_6893_4cad_9ef6_f1dca8ff6b2f
is encoded by: hsa:3030
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: E9KL44
name: HADHA
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_817ca63e_bbf4_4c9c_a95f_90a68254ea3d
initial concentration: NaN
name: DGUOK
constant: false
has only substance units: false
is: E5KSL6
is: SBO:0000252
is encoded by: hsa:1716
type: Species
boundary condition: true
initial amount: NaN

metaM xol7ah c
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: HMDB06892
constant: false
is: CHEBI:2290
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d6a8b3b2_3102_4461_955b_f6e2711ee193
is encoded by: hsa:10606
is: P22234
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PAICS
is: SBO:0000252
type: Species

metaR PPItr
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110035#
is described by: ECO:0000000
name: Diphosphate transporter, endoplasmic reticulum
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
fast: false

metaR FAOXTC122TC101m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR r0946
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
kinetic law: MODEL1310110035#

metaR DM gpi sig er
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR FORtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
name: FOR transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_5174ceba_1f22_4441_b3d1_7f827250bb54
has only substance units: false
is: Q674R7
name: ATG9B
type: Species
is encoded by: hsa:285973
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RDH2a
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
fast: false
modifier: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: retinol dehydrogenase (9-cis,NADPH)
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.105

http://identifiers.org/biomodels.db/MODEL1310110035#_6d0d42ef_b772_4709_8b1e_c05168786879
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:39
is: Q9BWD1
constant: false
name: ACAT2
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_3c31a4b8_5d2d_491f_a37d_9ae8b42aaa75
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9UJM8
type: Species
boundary condition: true
name: HAO1
has only substance units: false
is encoded by: hsa:54363
initial concentration: NaN

metaM spc hs c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: sphingosylphosphorylcholine
constant: false

metaM lys L e
is: SBO:0000247
name: L-lysinium(1+)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: CHEBI:32551
type: Species
constant: false
has only substance units: false

metaM ksii core4 g
constant: false
is: HMDB01644
initial amount: NaN
boundary condition: false
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: CHEBI:17140
type: Species
has only substance units: false

metaR r0668
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.19
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43

http://identifiers.org/biomodels.db/MODEL1310110035#_9dc5b700_4469_4fa0_af95_f59be9ad2e2e
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51251
is: Q9H0P0
name: NT5C3
type: Species

metaM ksii core2 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
is: HMDB00175
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_3e61c72c_b70e_41b3_814c_7beb86e27059
initial amount: NaN
is: C5HZ13
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: CLC
is encoded by: hsa:1178
is: SBO:0000252

metaM hs deg8 l
is: SBO:0000247
is: CHEBI:16126
name: heparan sulfate, degradation product 8
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d1eb7fd3_a7b1_4a1d_aa7f_551011ac8ebf
constant: false
has part: Q07837
boundary condition: true
initial amount: NaN
is encoded by: hsa:6519
has part: P82251
is: SBO:0000297
type: Species
initial concentration: NaN
name: SLC7A9:SLC3A1
has only substance units: false
is encoded by: hsa:11136

http://identifiers.org/biomodels.db/MODEL1310110035#_b047f4ab_d0da_46b6_b470_b5872f6590ad
is: SBO:0000252
is: Q9P0J0
is encoded by: hsa:51079
initial concentration: NaN
constant: false
name: NDUFA13
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM m2gacpail hs r
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
initial amount: NaN

metaM 4mop m
initial amount: NaN
has only substance units: false
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17865
is: SBO:0000247
name: 4-methyl-2-oxopentanoate

metaM thymd e
is: C00214
is: SBO:0000247
constant: false
name: Thymidine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17748
initial amount: NaN
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273

http://identifiers.org/biomodels.db/MODEL1310110035#_529604a5_c1c3_4c20_b83a_920d9671983a
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:U37519
name: _U37519_1_m
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_aa48c511_b97f_4590_822d_2ea70178108d
is: P30049
type: Species
has only substance units: false
name: ATP5D
constant: false
is encoded by: hsa:513
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0669
fast: false
reactant: MODEL1310110035#
reversible: false
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is described by: ECO:0000000
type: Reaction
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
kinetic law: MODEL1310110035#

metaM gbside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18259
type: Species
initial amount: NaN
name: globoside
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c0f5c561_76b8_4687_be50_05846b3c6707
constant: false
is: SBO:0000252
is: Q5T4W8
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110035#_3b9b9216_3b59_4e45_b1bc_c39d3b5b37ca
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2585
name: GALK2

metaR r0735
type: Reaction
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000

metaM g6p r
is: SBO:0000247
is: CHEBI:61548
constant: false
is: C00092
type: Species
is: HMDB01401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN
boundary condition: false
name: D-Glucose 6-phosphate
has only substance units: false
initial concentration: 1.0

metaM utp e
boundary condition: false
has only substance units: false
is: CHEBI:46398
is: HMDB00285
name: UTP(4-)
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r1291
type: Reaction
fast: false
is: SBO:0000185
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000

metaR TRPHYDRO2
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.4
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110035#
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
type: Reaction

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM lald L c
is: CHEBI:18041
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: HMDB03052
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: (S)-lactaldehyde

metaM galgalthcrm hs g
is: CHEBI:26174
initial concentration: 1.0
is: SBO:0000247
name: Gal-Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_aa301a93_2923_440f_ae6a_b295e5990f61
boundary condition: true
type: Species
name: CHAT
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q6LEN5
initial concentration: NaN
is encoded by: hsa:1103

metaR LNLNCGt
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion

metaR 3MOBt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
reversible: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

metaM sphs1p e
initial concentration: 1.0
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
has only substance units: false
boundary condition: false
is: HMDB00277
is: SBO:0000247
initial amount: NaN
constant: false

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is described by: ECO:0000134
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
name: diphopshate transporter, mitochondrial
fast: false
is: SBO:0000185
type: Reaction

metaR S6TASE25ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_8c175fc0_a72e_4d8f_a677_dda2ea3d882a
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: PDE5A
is encoded by: hsa:8654
constant: false
initial concentration: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM ksi pre26 g
type: Species
initial amount: NaN
is: CHEBI:28067
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 26
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_e2d93461_2bdf_4f70_9190_304e627e33ff
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6487
constant: false
is: Q5T4Y1
name: ST3GAL3
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_fc48ad06_a0da_4bd5_a729_e093a0923d5d
name: PPCS
is: SBO:0000252
has only substance units: false
is: Q9HAB8
is encoded by: hsa:79717
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c2e9446e_bc97_4a05_bfca_a0282c823f60
initial amount: NaN
name: SLC25A1
is: D9HTE9
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6576
constant: false
boundary condition: true

metaM gbside hs l
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
name: globoside

metaM utp c
constant: false
name: UTP
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
is: HMDB00285
is: C00075
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 4abutn m
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: 4-ammoniobutanal
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
initial concentration: 1.0
is: HMDB01080
type: Species

metaR H2CO3D
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
product: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
type: Reaction
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
name: carboxylic acid dissociation

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM CE5120 m
name: trans-2-cis-8-tetradecadienoyl-CoA
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
type: Species
is: CHEBI:57923
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r2397
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
fast: false
kinetic law: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
is: SBO:0000185

metaR AMETtd
reversible: true
product: MODEL1310110035#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
name: diffusion of S-Adenosyl-L-methionine
type: Reaction

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
fast: false

metaM acgam c
boundary condition: false
name: N-acetyl-D-glucosamine
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00215
initial amount: NaN
is: CHEBI:17411

metaM ksi pre30 g
is: C00130
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 30
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
has only substance units: false

metaR ALATHRNaEx
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110035#
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR BHBtm
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is: SBO:0000185
type: Reaction

metaM dgsn m
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247
is: HMDB00085
name: Deoxyguanosine
boundary condition: false
is: CHEBI:17172

http://identifiers.org/biomodels.db/MODEL1310110035#_09c6d2f2_7d94_47b3_abfc_da14a960f76b
initial concentration: NaN
constant: false
is: P51687
initial amount: NaN
boundary condition: true
is encoded by: hsa:6821
type: Species
is: SBO:0000252
has only substance units: false
name: SUOX

metaR RE0583C
product: MODEL1310110035#
name: RE0583
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#

metaR r1292
name: Postulated transport reaction
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_52549dae_755c_4ffd_95a3_ab8aef0256d7
is: Q9NSW9
name: SLC9A5
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6553
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_51fb2290_14c6_4555_9ee9_610878147676
has only substance units: false
is: O95573
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2181
boundary condition: true
name: ACSL3
initial concentration: NaN

metaR r0310
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
fast: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3

metaR INSTt2r
name: inositol transport in via proton symport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110035#
fast: false
type: Reaction
reactant: MODEL1310110035#
reversible: true

metaR CYANt
is described by: ECO:0000000
name: Cyanide transport via diffusion (extracellular to cytosol)
product: MODEL1310110035#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_18fb6d1e_b1df_4564_8627_56707318deda
is encoded by: hsa:51477
initial concentration: NaN
name: ISYNA1
boundary condition: true
has only substance units: false
initial amount: NaN
is: B3KRT1
is: SBO:0000252
type: Species
constant: false

metaM gly x
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
is: HMDB00123
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15428

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
constant: false
has only substance units: false
is: C00074
initial concentration: 1.0
boundary condition: false
name: Phosphoenolpyruvate
is: HMDB00263
initial amount: NaN
is: CHEBI:18021
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_2cbae7c8_d8c5_4d82_a1f6_405e4e1d4cfa
initial concentration: NaN
name: ST3GAL3
boundary condition: true
constant: false
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR GALt1r
type: Reaction
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
product: MODEL1310110035#
fast: false
is: SBO:0000185
name: galactose transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110035#_baf7a5ed_86ea_4643_840f_771f80a3ca58
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5092
is: SBO:0000252
constant: false
name: PCBD1
type: Species

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_f6ffb675_5105_48e2_b359_281bfb3b6091
constant: false
is: Q8WUX1
type: Species
is encoded by: hsa:92745
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC38A5
boundary condition: true

metaM arach c
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
is: HMDB02212
name: arachidate
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r0739
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reactant: MODEL1310110035#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaM dolmanp L r
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
constant: false
is: CHEBI:15809

metaR r0311
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_335d0757_6d43_47d7_b6c9_93edb6a2d205
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q53HE2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7167
name: TPI1
is: SBO:0000252

metaM cgly c
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-cysteinylglycine
has only substance units: false
is: CHEBI:4047
is: HMDB00078
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM dudp m
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: CHEBI:60471
constant: false
name: dUDP(3-)
initial amount: NaN
boundary condition: false
is: HMDB01000

metaM 3dsphgn c
has only substance units: false
initial concentration: 1.0
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
type: Species
is: HMDB01480
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
initial amount: NaN
is: SBO:0000247
is: CHEBI:58299
constant: false
boundary condition: false

metaR S6TASE1ly
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110035#
is: SBO:0000176

metaM HC01408 m
boundary condition: false
type: Species
is: CHEBI:27648
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0ce5b9a6_326f_45df_a697_d47f62fe531d
constant: false
has only substance units: false
is encoded by: hsa:50487
boundary condition: true
type: Species
is: Q9NZ20
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PLA2G3

metaM udpg r
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58367
constant: false
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaR r0424
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction

metaM 3mop m
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00491
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d06803ba_33fb_4b46_8f2f_92938a3b454e
is: B3KN25
name: CEPT1
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10390
is: SBO:0000252
initial concentration: NaN

metaR FACOAL160i
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
name: C160 fatty acid activation
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
type: Reaction

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM dudp n
is: CHEBI:60471
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01000
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
has only substance units: false
initial amount: NaN
name: dUDP(3-)

metaR ACONTm
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110035#
fast: false
name: Aconitate hydratase
is: SBO:0000176
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000134
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical

metaR DHORD9
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
name: dihydoorotic acid dehydrogenase (quinone10)
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.5.2
kinetic law: MODEL1310110035#

metaR r0514
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
reactant: MODEL1310110035#

metaM cgly e
constant: false
initial concentration: 1.0
name: L-cysteinylglycine
is: CHEBI:4047
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: SBO:0000247
is: HMDB00078

metaR FAOXC184x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM CE4791 x
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
is: CHEBI:57923
initial concentration: 1.0
constant: false
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110035#_0319a4f1_656b_4128_88b5_55846b1837d5
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2820
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P43304
name: GPD2

http://identifiers.org/biomodels.db/MODEL1310110035#_0213608e_ae83_4b9b_bfcb_f26060a8cb32
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1103
boundary condition: true
initial concentration: NaN
is: D3DX95
initial amount: NaN
type: Species
constant: false
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110035#_b8665852_b97b_4af9_9187_d30852688e35
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SCD
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6319
is: O00767

http://identifiers.org/biomodels.db/MODEL1310110035#_02189441_9d9e_4ba0_8f75_d2dffc0deb5b
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8854
constant: false
type: Species
name: ALDH1A2
initial amount: NaN
is: B4DZR2
boundary condition: true
has only substance units: false

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM lys L m
initial concentration: 1.0
initial amount: NaN
is: HMDB00182
is: CHEBI:32551
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9da68046_9f0a_44c6_a0f1_6a27b28bbc39
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: PDE7A
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5150

metaM gthox m
is: HMDB03337
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
type: Species
initial concentration: 1.0
has only substance units: false

metaR PROSTGH2t
name: Prostaglandin H2 transport
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
reversible: true

metaR HESTRATRIOLtr
name: hydroxylated estrogen derivative transport
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_668c5734_fd65_47bd_894a_ac2d9466a5f8
is: SBO:0000252
name: GPAA1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8733
is: O43292
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_2d55d82e_794d_477f_8d9a_569a940dadbd
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:3158
initial concentration: NaN
name: HMGCS2
initial amount: NaN
constant: false
is: P54868

http://identifiers.org/biomodels.db/MODEL1310110035#_2b1c2261_d04d_4abc_9978_51cd4672bb22
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:36
name: ACADSB
initial amount: NaN
is: P45954
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_47baee67_7d83_4613_892f_f00a07e45639
is encoded by: hsa:5295
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: PIK3CD:PIK3R1
constant: false
has part: E7EX19
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110035#_1aa21039_28c9_4936_9ae3_1e512e17c537
is encoded by: hsa:11001
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O14975
name: SLC27A2
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: lipid, flip-flop intracellular transport

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
type: Reaction
modifier: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_e66c0fc8_217a_4df7_a9c5_a77a1a3751c5
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:56301
has only substance units: false
is: Q9NS82
name: SLC7A10
initial amount: NaN
constant: false
initial concentration: NaN

metaR r0426
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
product: MODEL1310110035#
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR RE2998M
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
fast: false
reversible: false
name: RE2998
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaM thf m
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
is: C00101
is: SBO:0000247
is: HMDB01846
is: CHEBI:57453
boundary condition: false
constant: false

metaM thymd m
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
has only substance units: false
initial concentration: 1.0
name: Thymidine
is: SBO:0000247
initial amount: NaN
is: CHEBI:17748
type: Species
is: C00214
boundary condition: false
constant: false

metaR UDPDOLPT L
modifier: MODEL1310110035#
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.117
fast: false

metaM dcacoa c
initial concentration: 1.0
is: HMDB06404
is: SBO:0000247
is: C05274
is: CHEBI:61430
has only substance units: false
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
initial amount: NaN

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR RE1527M
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
name: RE1527

metaR ALCD21 L
reversible: false
fast: false
type: Reaction
name: alcohol dehydrogenase (L-1,2-propanediol)
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000304

metaR r0661
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM sphs1p c
boundary condition: false
has only substance units: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
type: Species
is: HMDB00277
initial amount: NaN
initial concentration: 1.0
constant: false

metaR CO2t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
product: MODEL1310110035#
type: Reaction
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: CO2 transporter via diffusion
reactant: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_8aca56fc_9459_4a37_a2f4_b665a85c10b4
name: GAL3ST1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q99999
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:9514

metaR ILETA
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
fast: false
is described by: ECO:0000269
name: isoleucine transaminase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM gmp g
is: CHEBI:58115
constant: false
type: Species
name: GMP(3-)
is: HMDB01397
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR EX adp
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR r2381
fast: false
product: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110035#

metaM tettet6coa c
boundary condition: false
has only substance units: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481
is: HMDB06516
is: C16171
name: tetracosatetraenoyl coenzyme A
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM man l
constant: false
is: CHEBI:16024
name: D-mannose
type: Species
has only substance units: false
boundary condition: false
is: HMDB00169
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_df2965a4_f872_4d14_9783_1f52e1fd4231
initial concentration: NaN
type: Species
has only substance units: false
is: Q6ZMU0
is: SBO:0000252
name: ALAD
boundary condition: true
is encoded by: hsa:210
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7805b61e_1cbb_4f87_bfcc_eb4cafa9cc58
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:116255
name: MOGAT1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q96PD6

metaR r1260
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
fast: false
is: SBO:0000176

metaM gthox c
initial amount: NaN
name: Oxidized glutathione
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB03337
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
is: C00127
initial concentration: 1.0
is: CHEBI:58297

metaR GLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110035#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000185
name: glycerol transport via channel
reversible: true
type: Reaction
reactant: MODEL1310110035#

metaR FAOXC102C103m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR HCO3 CLt
reactant: MODEL1310110035#
product: MODEL1310110035#
name: bicarbonate transport (Cl-/HCO3- exchange)
fast: false
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110035#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#

metaM tetdecdicoa x
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
type: Species
is: HMDB02288
is: SBO:0000247
initial concentration: 1.0

metaR 34DHPLACOX NADP
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_fc277760_6855_4a9a_afbd_3926bcac7eed
type: Species
is: Q15181
name: PPA1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5464

http://identifiers.org/biomodels.db/MODEL1310110035#_81af9f29_5ca2_4bcc_90db_3ac746f8730f
has part: Q9UHI5
is: SBO:0000297
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SLC7A8:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110035#_e5e88d42_ab3e_4ba4_8295_6c15e82d2f2e
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:686
is: SBO:0000252
initial amount: NaN
is: P43251
constant: false
name: BTD

http://identifiers.org/biomodels.db/MODEL1310110035#_512edb23_43dd_4718_8398_d6503776c160
is encoded by: hsa:2678
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: GGT1
has only substance units: false
is: SBO:0000252
type: Species

metaM ha deg1 l
initial amount: NaN
name: hyaluronan degradation product 1
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
is: CHEBI:16336

metaR r2382
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1ecd0e78_07fb_4620_a871_3ff7788d0bf5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3157
type: Species
name: HMGCS1
constant: false
initial amount: NaN
boundary condition: true

metaR B3GNT33g
reversible: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR CYSALANaEx
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR r1823
modifier: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_59708924_2e1c_43c2_a940_4a07732c84d1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11253
constant: false
has only substance units: false
boundary condition: true
is: Q9UKM7
name: MAN1B1
type: Species
initial amount: NaN

metaR FUT18g
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
is: SBO:0000176
reactant: MODEL1310110035#
name: Galactoside 2-alpha-L-fucosyltransferase 1
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69

http://identifiers.org/biomodels.db/MODEL1310110035#_e81fa312_c792_47cd_94c6_8f84fb78234a
name: ACPP
type: Species
constant: false
is: SBO:0000252
is: P15309
is encoded by: hsa:55
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_28bf5d39_85a4_48b7_9379_8a07b6c1f80a
boundary condition: true
name: B3GNTL1
has only substance units: false
constant: false
is encoded by: hsa:146712
initial amount: NaN
is: Q67FW5
is: SBO:0000252
initial concentration: NaN
type: Species

metaM HC02180 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28728
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
constant: false
type: Species

metaR GALSIDEtg
name: galactocerebroside intracellular transport
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
fast: false
type: Reaction

metaM gdpddman c
is: HMDB01346
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57964
constant: false

metaM trp L c
constant: false
name: L-tryptophan
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
has only substance units: false
is: CHEBI:16828
type: Species
is: SBO:0000247
is: HMDB00929
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_e910ec7a_c8ce_4235_b608_e66096266aeb
is encoded by: hsa:6582
name: SLC22A2
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: O15244
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_7a261b92_3052_4860_ad67_9d7786d3580b
type: Species
is encoded by: hsa:2222
initial concentration: NaN
boundary condition: true
name: FDFT1
constant: false
is: P37268
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM gmp e
is: CHEBI:58115
name: GMP(3-)
type: Species
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0744
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
kinetic law: MODEL1310110035#
fast: false
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
reversible: false

metaM CE2705 c
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial amount: NaN
is: CHEBI:36781
name: quinonoid dihydrobiopterin
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaM cholp g
has only substance units: false
is: C00588
constant: false
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:295975
name: choline phosphate(1-)
is: SBO:0000247

metaR UGCG
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.80
fast: false
reversible: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is described by: ECO:0000000
name: Ceramide glucosyltransferase
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaM prostge2 e
is: SBO:0000247
is: CHEBI:606564
is: HMDB01220
initial amount: NaN
name: prostaglandin E2(1-)
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM chsterol l
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
initial concentration: 1.0
constant: false
is: HMDB00067
boundary condition: false
is: CHEBI:16113
name: cholesterol
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR STRDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
fast: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_e53746fe_a238_4ba3_9eb9_e2a62fab3fc1
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: B4DX62
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487

metaM 34dhoxmand c
is: HMDB01866
boundary condition: false
is: CHEBI:27637
is: SBO:0000247
has only substance units: false
type: Species
name: 3,4-Dihydroxymandelate
constant: false
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0

metaM ahcys r
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: CHEBI:16680
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00939
initial amount: NaN
name: S-adenosyl-L-homocysteine

http://identifiers.org/biomodels.db/MODEL1310110035#_0f0c5ae9_3c5b_4fa1_902f_528d5a86c9c3
has only substance units: false
is: Q7Z4L0
type: Species
name: COX8C
boundary condition: true
initial amount: NaN
is encoded by: hsa:341947
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0743
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
reversible: false
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
is described by: ECO:0000000

metaM hs l
name: heparan sulfate, free chain
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
is: CHEBI:28815

metaR NTD2e
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (UMP), extracellular
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134
fast: false

metaR r2380
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR FAOXC140
kinetic law: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is: SBO:0000176

metaR DLNLCGt
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

metaR LDH D
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
modifier: MODEL1310110035#
type: Reaction
fast: false
name: D-lactate dehydrogenase
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110035#

metaM chsterol m
name: cholesterol
is: HMDB00067
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
initial amount: NaN
is: CHEBI:16113
initial concentration: 1.0

metaR FAOXC2252053m
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110035#
fast: false
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid

metaM ade c
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
constant: false
boundary condition: false
is: HMDB00034
is: CHEBI:16708
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: C00147
name: Adenine

http://identifiers.org/biomodels.db/MODEL1310110035#_e7d67b1a_034c_405b_aad9_4843c55b3c74
is encoded by: hsa:9435
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: Q9Y4C5
initial concentration: NaN
name: CHST2
boundary condition: true
has only substance units: false

metaM occoa c
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
has only substance units: false
boundary condition: false
is: C01944
is: HMDB01070
initial amount: NaN
is: SBO:0000247
type: Species

metaR DHCRD1
is: SBO:0000176
modifier: MODEL1310110035#
name: dihydroceramide desaturase
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
product: MODEL1310110035#
fast: false
type: Reaction

metaM gmp c
has only substance units: false
name: GMP
constant: false
type: Species
is: C00144
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR UMPK7
modifier: MODEL1310110035#
name: UMP kinase (dGTP)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110035#
type: Reaction
fast: false

metaR r1608
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR G14T2g
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR GALSIDEtl
type: Reaction
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
name: galactocerebroside intracellular transport
reversible: true
is: SBO:0000185

metaM HC01434 x
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
name: oxalatosuccinate(3-)
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58931
boundary condition: false

metaR PMEVKc
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
product: MODEL1310110035#
name: phosphomevalonate kinase, cytosol
reversible: false
modifier: MODEL1310110035#
is described by: ECO:0000134
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.

http://identifiers.org/biomodels.db/MODEL1310110035#_156edbe6_28ba_41df_a934_8892d42c8f45
is: A6NDW6
initial concentration: NaN
is encoded by: hsa:79053
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ALG8
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_e5fec9c7_ddcb_4b7d_a2c0_97ee6dd152b6
is: SBO:0000252
initial concentration: NaN
is: E9PAK4
is encoded by: hsa:200010
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC5A9

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR RE0512M
is: SBO:0000176
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512
reactant: MODEL1310110035#
is described by: ECO:0000000

metaR r1609
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000

metaR GLCt2 2
is described by: ECO:0000269
name: D-glucose transport in via proton symport
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reversible: true
type: Reaction

metaM Ssq23epx r
boundary condition: false
constant: false
is: HMDB01188
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: (S)-2,3-epoxysqualene
is: CHEBI:15441
type: Species
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

metaR r0741
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110035#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
type: Reaction
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_a165ae38_2d4c_4f23_aace_13e80183b075
name: PIGW
boundary condition: true
is encoded by: hsa:284098
constant: false
initial concentration: NaN
is: Q7Z7B1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM C05280 m
constant: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
has only substance units: false
initial amount: NaN
name: cis,cis-3,6-Dodecadienoyl-CoA
boundary condition: false
is: CHEBI:28002
initial concentration: 1.0
is: HMDB03952

metaM ade e
is: SBO:0000247
type: Species
is: CHEBI:16708
initial amount: NaN
has only substance units: false
constant: false
name: adenine
is: HMDB00034
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147

http://identifiers.org/biomodels.db/MODEL1310110035#_174f2053_df64_4bc2_ae28_73737497a5e7
initial concentration: NaN
type: Species
name: NME2
is encoded by: hsa:4831
has only substance units: false
is: P22392
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR ORNt4m
is described by: ECO:0000269
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110035#

metaR UMPK5
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: UMP kinase (dATP)
modifier: MODEL1310110035#
is described by: ECO:0000269

metaR r0009
reversible: false
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1

metaM phyt2ohcoa x
boundary condition: false
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial concentration: 1.0
name: 2-hydroxyphytanoyl-CoA(4-)
has only substance units: false
is: CHEBI:57334
initial amount: NaN
is: HMDB01295
is: SBO:0000247
type: Species
constant: false

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_9bc2c52d_3661_4cbd_b81c_ec299c75639d
is: SBO:0000252
is: F8WDN9
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:27068
constant: false
name: PPA2
initial amount: NaN
type: Species

metaR ECOAH12m
modifier: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_81ab0fee_4527_4d09_a4cf_2199b20d9ce6
name: SLC5A1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: P13866
is encoded by: hsa:6523
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_d3a9514c_731a_47e6_94be_8f1f27fca3f4
name: AK2
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P54819
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:204

metaR NADtn
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
reactant: MODEL1310110035#
name: NAD transport, nuclear through pores
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_e2d96ab3_150b_431a_b6aa_0480993452c2
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55229
boundary condition: true
name: PANK4
type: Species
is: Q9NVE7
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_bfee7b14_c8e5_41cb_94fd_7405fd19eda5
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: DGUOK
boundary condition: true
is encoded by: hsa:1716
is: E5KSL5

metaM HC02180 c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28728
name: thromboxane-b2
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false

metaR NACHEX25ly
reversible: false
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaR UMPK6
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110035#
fast: false
name: UMP kinase (dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 2mop c
is: CHEBI:57700
name: 2-methyl-3-oxopropanoate
boundary condition: false
initial concentration: 1.0
is: HMDB01172
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false

metaR r1607
reactant: MODEL1310110035#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#

metaR RETHe
name: retinyl ester hydrolase, extracellular
reversible: false
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e72fb170_b071_458f_a3e6_23b3c1041af1
name: NMNAT3
is encoded by: hsa:349565
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q96T66
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f4e754a1_6ad9_436a_9b62_ba602586f224
initial concentration: NaN
is encoded by: hsa:768
name: CA9
type: Species
initial amount: NaN
is: Q16790
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_9db8d7a8_bc8f_4f85_89aa_3ef0ddc43f7c
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:R39999
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: _R39999_1_c

metaR FAOXC2252053x
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110035#_d35623d8_d622_4dc2_a1cd_ca7bc73643dc
has only substance units: false
constant: false
initial amount: NaN
is: Q96DU7
boundary condition: true
name: ITPKC
type: Species
is: SBO:0000252
is encoded by: hsa:80271
initial concentration: NaN

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR FACOAL260
name: fatty-acid--CoA ligase (n-C26:0)
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
fast: false
reactant: MODEL1310110035#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

metaM chsterol r
constant: false
is: CHEBI:16113
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
initial concentration: 1.0
name: cholesterol
type: Species
is: HMDB00067

metaR MDHm
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.37
is described by: ECO:0000134
is: SBO:0000176
name: malate dehydrogenase, mitochondrial
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical

metaR PACCOAL
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
fast: false
name: phenylacetate-CoA ligase
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
reactant: MODEL1310110035#

metaR UMPK3
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (UTP)
reversible: true
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction

metaM CE2421 m
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB02329
initial concentration: 1.0
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Vitamin D3 uptake
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
constant: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:16094
is: HMDB00257
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaR HSD17B4x
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
type: Reaction
name: hydroxysteroid (17-beta) dehydrogenase 4
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
modifier: MODEL1310110035#

metaM 34dhoxmand m
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247
boundary condition: false
is: HMDB01866
initial amount: NaN
constant: false
type: Species
name: 3,4-Dihydroxymandelate
has only substance units: false
is: CHEBI:27637
initial concentration: 1.0

metaM pan4p e
is: HMDB01416
initial concentration: 1.0
is: CHEBI:47942
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
initial amount: NaN
is: C01134
name: Pantetheine 4'-phosphate
type: Species
is: SBO:0000247

metaM ksi deg35 l
is: CHEBI:12936
is: HMDB00143
has only substance units: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 35
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_37fc4258_064f_40f4_b57b_c9ee4f86f0bd
name: _AI926493_1_c
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI926493
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_54487957_8308_4e89_b97f_cc3d76b66e2d
is encoded by: hsa:83697
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: E9PDK1
name: SLC4A9
has only substance units: false

metaR HACD9m
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is described by: ECO:0000134
product: MODEL1310110035#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_92c41d26_f6ef_4048_9209_e63cce413ae3
boundary condition: true
is: Q9H6R3
is: SBO:0000252
name: ACSS3
initial amount: NaN
is encoded by: hsa:79611
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM ser D c
is: HMDB03406
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16523
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
type: Species
initial concentration: 1.0
name: D-serine

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_006d741f_77b8_49bf_8268_9b7fb1d09f35
is encoded by: hsa:2974
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: GUCY1B2

metaR NCNt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
fast: false
reversible: true
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110035#

metaR UMPK4
modifier: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000269
reversible: true
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM ksi deg28 l
initial concentration: 1.0
is: CHEBI:16953
initial amount: NaN
constant: false
is: HMDB00812
name: keratan sulfate I, degradation product 28
is: SBO:0000247
boundary condition: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
has only substance units: false
type: Species

metaM 2mop m
is: CHEBI:57700
is: HMDB01172
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0

metaM gmp n
boundary condition: false
has only substance units: false
name: GMP(3-)
is: HMDB01397
initial concentration: 1.0
is: CHEBI:58115
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN

metaR r0975
name: Facilitated diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_2b7b11ba_3bfd_424b_9ac4_dabdcc089ef0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q9H008
is encoded by: hsa:64077
name: LHPP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f0befbe5_a848_4e89_9290_e3cfc44fb31c
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: ENTPD6
type: Species
constant: false
is: O75354
initial concentration: NaN
is encoded by: hsa:955

metaM 13dpg c
is: SBO:0000247
is: HMDB01270
is: CHEBI:57604
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: C00236
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c9a44796_2b2e_4d0f_94c4_237b70d8f8cb
name: NOS3
is encoded by: hsa:4846
is: A0S0A7
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaR FACOAL161
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110035#
reversible: true
fast: false
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_28fbc124_2b35_414d_bb3e_9b6a5e969e89
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q16698
has only substance units: false
is encoded by: hsa:1666
type: Species
initial amount: NaN
boundary condition: true
name: DECR1

http://identifiers.org/biomodels.db/MODEL1310110035#_79953b0d_ce2e_469e_a5f1_bdb44367b6f2
is: O00337
has only substance units: false
name: SLC28A1
initial concentration: NaN
is encoded by: hsa:9154
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM HC01434 m
is: CHEBI:58931
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: oxalatosuccinate(3-)
has only substance units: false

metaR GPIMTer U
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_45fb08d8_5ad5_4c2e_ae6f_2ac2679039dd
has only substance units: false
name: PRDX1
type: Species
boundary condition: true
constant: false
is: Q06830
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5052
initial amount: NaN

metaR RTOTALFATPc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_a8a79174_3cd1_4d05_b114_526a2b521650
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: SLC6A10P
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:386757

metaR r0974
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
type: Reaction
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
name: Active transport
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_3c5c7f9a_dc55_4a28_9fe3_c5dad7ad9e0e
initial amount: NaN
is encoded by: hsa:4831
name: NME2
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P22392

metaR APOC LYS BTNP
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
name: proteolysis of apoC-Lys-btn
is described by: ECO:0000000
product: MODEL1310110035#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110035#

metaM pan4p c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:47942
is: HMDB01416
constant: false
is: C01134
name: Pantetheine 4'-phosphate
initial amount: NaN
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaR NTD2m
reversible: false
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (UMP), mitochondrial
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110035#
type: Reaction

metaM 4abutn c
is: SBO:0000247
is: HMDB01080
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58264
is: C00555
constant: false
has only substance units: false
name: 4-Aminobutanal
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR UMPK2
type: Reaction
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
name: UMP kinase (CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM ser D e
name: D-serine
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:16523
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
is: HMDB03406

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: geranyltranstransferase
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110035#
is described by: ECO:0000134
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_7a0ab866_83d8_4c0d_9c5c_21daa5632e5a
type: Species
has part: P48201
constant: false
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:518

metaR r0638
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110035#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.8.1.2

metaR ITCOAL1m
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176

metaR r0973
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
kinetic law: MODEL1310110035#
fast: false
type: Reaction
product: MODEL1310110035#
reversible: true
is: SBO:0000185
name: Facilitated diffusion

metaR RE3244R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
name: RE3244
is: SBO:0000176

metaM ksii core4 pre4 g
is: CHEBI:58053
constant: false
is: HMDB00175
has only substance units: false
is: C00130
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4
boundary condition: false

metaR RE1534M
is: SBO:0000176
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1534
reversible: true
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false

metaM CE2705 n
type: Species
name: quinonoid dihydrobiopterin
boundary condition: false
has only substance units: false
is: CHEBI:15374
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB02281

metaM 13dampp c
name: trimethylenediaminium
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
initial amount: NaN
is: CHEBI:57484
constant: false
is: HMDB00002
has only substance units: false
type: Species

metaR HESTRATRIOLte
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
name: hydroxylated estrogen derivative transport

http://identifiers.org/biomodels.db/MODEL1310110035#_9fc7dbfe_9130_422a_aa33_c2a70f681adc
constant: false
name: PRPS1L1
type: Species
boundary condition: true
is: P21108
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:221823

metaR GCNTg
fast: false
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
reversible: false
modifier: MODEL1310110035#
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.150

http://identifiers.org/biomodels.db/MODEL1310110035#_6146b568_73c2_4965_ba7d_3d40fc4dee48
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q02221
type: Species
boundary condition: true
is encoded by: hsa:1339
initial amount: NaN
name: COX6A2

metaR FAOXC227C226m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM trp L e
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
type: Species
is: HMDB00929
boundary condition: false
initial concentration: 1.0
name: L-tryptophan
is: SBO:0000247
has only substance units: false
constant: false

metaM prostge2 c
initial amount: NaN
constant: false
name: prostaglandin E2(1-)
is: HMDB01220
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
is: CHEBI:606564

http://identifiers.org/biomodels.db/MODEL1310110035#_2e7f950d_af11_4c70_82ad_30b143359baa
name: SULT1A1
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6817
constant: false

metaM ksii core4 l
constant: false
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
type: Species
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
has only substance units: false
is: CHEBI:17140
boundary condition: false
is: HMDB01644

metaM cs b l
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:36005
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
initial amount: NaN
is: HMDB02183
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_727bc01f_2ba1_4bee_877d_d1b2dc0c52c1
is encoded by: hsa:3032
is: SBO:0000297
is encoded by: hsa:3030
name: HADHA:HADHB
has only substance units: false
boundary condition: true
initial concentration: NaN
has part: P55084
has part: E9KL44
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9c8b54b6_9404_49b2_ab98_23adb45d34fb
name: CHST6
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9GZX3
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4166
type: Species

metaR DMHPTCRNt
is described by: ECO:0000000
name: 2,6 dimethylheptanoyl crn transport
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
reversible: true

metaM g6p c
is: C00092
is: CHEBI:61548
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial concentration: 1.0
name: D-Glucose 6-phosphate
boundary condition: false
type: Species
is: HMDB01401

metaR FAOXC102C103x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_3c4b413b_ac80_45ce_83fa_aef904c7f9f0
name: _AD000092_1_c
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AD000092

metaM man r
has only substance units: false
boundary condition: false
constant: false
name: D-mannose
is: CHEBI:16024
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
type: Species
initial concentration: 1.0
initial amount: NaN

metaM tetdecdicoa m
constant: false
is: SBO:0000247
boundary condition: false
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species

metaR KCCt
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_f41c3269_b5c2_4c19_bd3c_c44c7e4f80ad
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: Q8NCI4
boundary condition: true
name: PIGG
initial amount: NaN
is encoded by: hsa:54872
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_957b4e80_ef52_4532_81ba_426a83d07a3a
type: Species
initial concentration: NaN
is encoded by: hsa:3635
initial amount: NaN
is: SBO:0000252
name: INPP5D
boundary condition: true
constant: false
is: Q92835
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_565a2462_f1ed_40be_ba18_955258f1d016
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: CRAT
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1384

http://identifiers.org/biomodels.db/MODEL1310110035#_545e49ec_5936_4169_b519_4ace5908d51c
name: GGT1
is encoded by: hsa:2678
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is: SBO:0000176
name: deoxyuridine phosphorylase
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#

metaR LEUTA
name: leucine transaminase
is described by: ECO:0000269
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#

metaR FAOXC18480x
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false

metaR RETH1e
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: retinyl ester hydrolase (9-cis), extracellular
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_ea1658fc_5284_4d42_be58_6f038bda8b1f
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: A0N0X8
name: CYP1A1
type: Species
is encoded by: hsa:1543
has only substance units: false
constant: false

metaR FAOXC101C102m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR AG13T3g
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction

metaR PGLYCt
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
reversible: true
product: MODEL1310110035#
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
name: phosphatidylglycerol transport
type: Reaction
is: SBO:0000185

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110035#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110035#

metaM dttp n
boundary condition: false
type: Species
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00459
is: CHEBI:37568

metaR r0853
fast: false
product: MODEL1310110035#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
name: Facilitated diffusion
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:

metaM ahcys m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00939
constant: false
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
is: CHEBI:16680
is: C00021
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

http://identifiers.org/biomodels.db/MODEL1310110035#_f2b01f8b_faec_46bb_8133_3e72caef0f08
type: Species
is encoded by: hsa:4710
has only substance units: false
constant: false
boundary condition: true
name: NDUFB4
is: SBO:0000252
initial concentration: NaN
is: O95168
initial amount: NaN

metaR PRGNLONEtm
name: pregnenolone intracellular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

metaR DESAT22 2p
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_4a1431e0_b999_4fcd_ad46_01ddb9043175
is encoded by: hsa:516
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q6FIH7
constant: false
is: SBO:0000252
initial amount: NaN
name: ATP5G1
type: Species

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM tcynt m
name: thiocyanate
initial amount: NaN
is: CHEBI:18022
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01453
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_51475096_8343_40ef_8073_2f8904330102
has only substance units: false
is: B7Z792
is: SBO:0000252
constant: false
is encoded by: hsa:4720
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFS2

http://identifiers.org/biomodels.db/MODEL1310110035#_d33066b9_233c_4d38_ac86_37dce62be409
has only substance units: false
name: DGKZ
is: G3V0F6
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:8525
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR 35CGMPtn
name: 35cGMP nuclear transport
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM accoa g
type: Species
name: acetyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial amount: NaN
is: HMDB01206
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57288

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM 6thf e
boundary condition: false
initial amount: NaN
name: hexaglutamyl folate (THF)
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
type: Species

metaM leuktrE4 c
is: SBO:0000247
has only substance units: false
is: HMDB02200
boundary condition: false
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
name: leukotriene E4(1-)
initial concentration: 1.0
constant: false
type: Species

metaR ACONT
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
is: SBO:0000176
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
name: aconitase

metaR FAOXC225m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM thym m
is: HMDB00262
name: thymine
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
is: CHEBI:17821
constant: false

metaM 10fthf5glu e
constant: false
is: SBO:0000247
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: HMDB00972
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110035#_10a3c221_c78d_447e_a89a_d99fb885e17b
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:H77542
initial concentration: NaN
type: Species
name: _H77542_1_c

metaM CE4792 m
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0a66d47d_430c_4927_a87e_6e64ceb87424
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:286016
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: TPI1P2

http://identifiers.org/biomodels.db/MODEL1310110035#_530892d2_8b46_44de_918e_cd1bf5edb5c5
is encoded by: hsa:222
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH3B2
is: P48448
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_53e7ea91_c5b7_4987_87a9_673e9831b9df
name: NDUFB3
constant: false
is: Q6IB80
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4709
boundary condition: true
type: Species

metaR r0633
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
modifier: MODEL1310110035#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176

metaM dcsptn1crn m
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
has only substance units: false
is: HMDB06321
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_edb6650e_3c09_46ba_86d5_081837ad15ee
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:54963
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: UCKL1
is: Q53HM1

http://identifiers.org/biomodels.db/MODEL1310110035#_fd3b608e_6459_4c69_889b_705d209f7b34
initial amount: NaN
boundary condition: true
is: Q6YFQ2
is encoded by: hsa:125965
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: COX6B2

metaM ahcys c
is: C00021
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
boundary condition: false
is: HMDB00939
initial concentration: 1.0
is: CHEBI:16680
is: SBO:0000247
name: S-Adenosyl-L-homocysteine

metaM mag hs e
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:60479
initial amount: NaN
name: monoacylglycerol 2
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaR STS1
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
kinetic law: MODEL1310110035#
is described by: ECO:0000269
name: Steryl-sulfatase
reversible: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction

metaR DMHPTCRNte
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
fast: false
reversible: true
is: SBO:0000185
name: 2,6 dimethylheptanoyl carnitine transport
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR FAOXC101C102x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_8baab0f5_6e41_43fe_a1da_67281c61ec3e
is: A0PJK1
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:125206
initial concentration: NaN
name: SLC5A10
boundary condition: true
is: SBO:0000252
constant: false

metaR KAS8
kinetic law: MODEL1310110035#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_f57ea181_6ce0_4f32_96e5_30f663ab26b9
initial amount: NaN
is: Q16720
has only substance units: false
type: Species
boundary condition: true
name: ATP2B3
initial concentration: NaN
is encoded by: hsa:492
is: SBO:0000252
constant: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaM HC00591 c
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_8af7c6a2_544a_4f35_8b92_7602318c3693
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:766
is: SBO:0000252
initial concentration: NaN
name: CA7
is: Q86YU0
type: Species

metaR ACNAM9PL
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.56
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
type: Reaction
reversible: false
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaM leuktrE4 e
is: CHEBI:57462
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
boundary condition: false
name: leukotriene E4(1-)
has only substance units: false
is: HMDB02200

metaR SO4t4 2
is described by: ECO:0000269
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
type: Reaction
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is: SBO:0000185
name: sulfate transport via sodium symport
reactant: MODEL1310110035#

metaR DINt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110035#
name: deoxyinosine transport via diffusion
fast: false
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_d45cb4e9_9920_43ad_9820_ad6c38ff5589
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI222095
has only substance units: false
type: Species
name: _AI222095_1_m

http://identifiers.org/biomodels.db/MODEL1310110035#_ca7ea92e_7b02_4dcf_861a_f62d438607a4
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: PDE6G
has only substance units: false
is: P18545
type: Species
is encoded by: hsa:5148

metaR r0630
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110035#
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false

metaR TSTSTERONESULT
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
type: Reaction
reactant: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.14
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
fast: false
name: testosterone sulfotransferase
is described by: ECO:0000269
product: MODEL1310110035#

metaR DRPA
reversible: false
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110035#
fast: false

metaR G6PDH1rer
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is: SBO:0000176
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110035#
reversible: true

metaR GLCNACASE5ly
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f1cda284_07d6_4330_93d6_e42629ee0559
is encoded by: hsa:23761
name: PISD
has only substance units: false
type: Species
initial amount: NaN
is: Q9UG56
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR DOPAtu
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
name: Dopamine uniport
modifier: MODEL1310110035#
fast: false
reversible: true
product: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_4ee94062_6889_41a8_a2e2_6d861ce246ec
has only substance units: false
name: ENTPD1
initial amount: NaN
type: Species
is encoded by: hsa:953
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q86VV3

http://identifiers.org/biomodels.db/MODEL1310110035#_6734fa08_b7da_4c5b_b1e4_0344e526f7fb
boundary condition: true
type: Species
is: B3KQ63
is: SBO:0000252
constant: false
initial amount: NaN
name: HPD
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3242

http://identifiers.org/biomodels.db/MODEL1310110035#_1cb65823_0bbb_4bcf_a6b0_1124e3080bc9
is: P54840
constant: false
type: Species
name: GYS2
is encoded by: hsa:2998
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM 3mob m
constant: false
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
boundary condition: false
is: HMDB00019

http://identifiers.org/biomodels.db/MODEL1310110035#_94da6046_7369_437b_a376_5c71248e00dc
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27034
constant: false
name: ACAD8
type: Species
boundary condition: true
initial concentration: NaN
is: Q6ZWP6

metaM ksii core2 pre6 g
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 6
type: Species
is: SBO:0000247

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM CE1926 e
is: SBO:0000247
has only substance units: false
is: HMDB00127
name: gama-carboxyethyl-hydroxychroman
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15748
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f688b4f4_e49c_44bc_85bf_30468cf41327
initial amount: NaN
is encoded by: hsa:2954
constant: false
has only substance units: false
is: O43708
name: GSTZ1
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR FAOXC101C8x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_6af738ad_49ec_42f8_9611_98c50acbe7a0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3948
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P07864
name: LDHC
initial concentration: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR OAGD3tg
name: oagd3 hs intracellular transport
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
type: Reaction
is described by: ECO:0000000

metaR ACCOAC
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM nmn c
is: CHEBI:14649
initial amount: NaN
type: Species
name: NMN
is: HMDB00229
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
has only substance units: false
is: C00455
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0636
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#

metaM accoa c
is: C00024
is: CHEBI:57288
type: Species
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Acetyl-CoA
initial amount: NaN

metaR FAOXC18480m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
product: MODEL1310110035#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_144607f8_5d1c_4b8b_8fda_5839137cf7ab
is: SBO:0000252
name: _LOC374569_1_e
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:LOC374569

metaR LINKDEG1ly
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
reversible: false
name: degradation of proteoglycan linkage region, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110035#_09393ce0_0e0f_4ba0_9764_edab5c117459
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _AI924226_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI924226

metaM tcynt c
name: thiocyanate
initial amount: NaN
is: CHEBI:18022
constant: false
is: HMDB01453
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR r0434
fast: false
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110035#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_9037256b_af51_42aa_958c_3fa2befb030d
type: Species
is: Q6NZ59
name: ATP5J
initial concentration: NaN
has only substance units: false
is encoded by: hsa:522
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_5979d3d4_fc63_4186_9566_4f3166928974
is encoded by: hsa:2739
constant: false
boundary condition: true
is: SBO:0000252
is: Q04760
initial concentration: NaN
name: GLO1
initial amount: NaN
type: Species
has only substance units: false

metaM pail34p hs c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_280df267_e129_4493_aba1_e5ee17cf80c6
is: SBO:0000297
is encoded by: hsa:5293
boundary condition: true
initial amount: NaN
name: PIK3CD:PIK3R3
constant: false
has part: A7E2E0
has only substance units: false
type: Species
has part: Q92569
is encoded by: hsa:8503
initial concentration: NaN

metaR r0637
name: Octanoyl-CoA:L-carnitine O-octanoyltransferase EC:2.3.1.137
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.137 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110035#
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_72584f08_5601_4cb8_98cc_0eebc6a9f6fe
boundary condition: true
type: Species
name: GMPR2
initial concentration: NaN
constant: false
is encoded by: hsa:51292
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3b4f1f25_7f60_4eb2_9918_c5fe632f9710
name: ENTPD8
is: Q5MY95
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:377841
boundary condition: true

metaR PIK3
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110035#
name: phosphatidylinositol 3-kinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110035#

metaR FACOAL245 2
is described by: ECO:0000269
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_af209553_83b2_44e3_a661_1a94462f3e74
constant: false
initial amount: NaN
is: Q546E0
initial concentration: NaN
name: FUT8
type: Species
is encoded by: hsa:2530
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM hom L e
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: L-homoserine
is: HMDB00719
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:15699

metaM air c
boundary condition: false
initial amount: NaN
is: C03373
constant: false
is: HMDB01235
is: SBO:0000247
type: Species
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: CHEBI:58592
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a17dbe4f_084e_4992_aa0b_95297ab5835c
is: SBO:0000252
is encoded by: hsa:4128
constant: false
is: Q53YE7
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: MAOA
boundary condition: true
type: Species

metaR r0634
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110035#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_a69337b8_b262_4132_b42e_05f80a758528
is encoded by: hsa:3098
name: HK1
initial amount: NaN
constant: false
is: B3KXY9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_9bfca934_3071_4b9c_9ded_ce2e5806aa47
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: ATP5J2
initial amount: NaN
is encoded by: hsa:9551
is: Q6IBB3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_e3e94fdd_dc1b_4526_b7b9_cf6fb8c5ccca
is encoded by: hsa:23236
has only substance units: false
is: SBO:0000252
name: PLCB1
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ba7504ad_e653_41f9_9b49_f8843148167e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC23A2
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9962

http://identifiers.org/biomodels.db/MODEL1310110035#_d177e25e_ee2f_46ff_8b71_0a4e1702c46a
is encoded by: hsa:84720
type: Species
is: SBO:0000297
is encoded by: hsa:5281
name: PIGF:PIGO
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
has part: Q6IB04
constant: false

metaR OAGD3te
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: oagd3 hs transport
is: SBO:0000185
reversible: true

metaM tcynt e
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN
is: CHEBI:18022
name: thiocyanate
constant: false
is: HMDB01453
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_11a15cf7_5896_4e2e_aea2_864f72c94672
name: SLC8A3
is encoded by: hsa:6547
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B3KU59

metaR FACOAL245 1
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110035#
reversible: false
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#

metaM retinol 9 cis e
constant: false
has only substance units: false
boundary condition: false
name: 9-cis-retinol
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial concentration: 1.0
is: SBO:0000247
is: HMDB06217
type: Species
initial amount: NaN

metaM pail45p hs c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_066f0c31_6480_440a_bdd6_f4d64359761a
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC27A2
constant: false
is encoded by: hsa:11001
is: O14975

metaR DM Ser Thr ly
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaR DOLMANP Uter
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110035#
fast: false

metaR UREAt
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185
name: Urea transport via facilitate diffusion
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#

metaR S2TASE1ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
product: MODEL1310110035#
name: iduronate-2-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110035#_f17fa13b_c8e4_4875_8da2_b0bd148af032
name: TREH
has only substance units: false
is: O43280
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11181

metaM mag hs c
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
name: monoacylglycerol 2
is: CHEBI:60479
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r1605
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dd3coa x
is: SBO:0000247
name: 3-dodecenoylcoa
is: HMDB04257
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false

metaM 3mob e
is: HMDB00019
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110035#_4d7204ce_0dd3_4686_82ba_3dab15cfaa80
is encoded by: hsa:3417
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: IDH1
is: O75874

http://identifiers.org/biomodels.db/MODEL1310110035#_a3d6a7a0_0c94_4773_9099_6373964003be
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9187
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC24A1
is: B4DUG1

metaM i c
is: HMDB12238
has only substance units: false
name: iodide
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16382
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaM pail45p hs m
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
is: SBO:0000247
is: CHEBI:28910
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM man e
initial concentration: 1.0
type: Species
name: D-Mannose
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
has only substance units: false
boundary condition: false
is: CHEBI:16024
constant: false
is: HMDB00169

metaM ksii core4 pre10 g
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species
initial amount: NaN
boundary condition: false

metaR FAOXC16080x
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_2837db68_5e97_4d71_9f9d_2834f5bc9b2c
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:8659
name: ALDH4A1

metaR r0527
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
product: MODEL1310110035#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110035#

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

metaM hom L c
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: HMDB00719
constant: false
type: Species
name: L-homoserine
boundary condition: false
is: CHEBI:15699
is: SBO:0000247
initial concentration: 1.0

metaR DNDPt35m
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110035#
name: dGDP transport via dADP antiport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6f49facc_ffa7_4f3c_ae07_df528dc24b3a
is: O95169
has only substance units: false
is encoded by: hsa:4714
boundary condition: true
name: NDUFB8
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR r1604
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pail45p hs n
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28910
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110035#_77b10f7b_c83e_4ceb_b1da_f9fbb2546b59
is: Q7Z364
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5153
initial concentration: NaN
name: PDE1B
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_5ca14625_f8c2_470f_b2d6_194562ec3530
name: ARSB
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:411
is: P15848
boundary condition: true

metaR GLNSERNaEx
modifier: MODEL1310110035#
reversible: false
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
fast: false
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM lneldc e
is: HMDB06270
type: Species
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
constant: false
name: linoelaidic acid (all trans C18:2)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaM ksi deg27 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 27
type: Species
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
is: HMDB00143
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_92e8e5af_3e03_4b3f_8927_27b4aa9598f3
has only substance units: false
initial amount: NaN
type: Species
name: _AU149534_1_c
boundary condition: true
is encoded by: hsa:AU149534
initial concentration: NaN
constant: false
is: SBO:0000252

metaM thym c
initial amount: NaN
name: Thymine
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00262
boundary condition: false
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
is: C00178
has only substance units: false

metaR MTHFR3
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.5.1.20
product: MODEL1310110035#

metaR r2389
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110035#
reversible: false
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM tetpent6 c
boundary condition: false
name: tetracosapentaenoic acid, n-6
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB06322
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM retinol 9 cis c
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
initial concentration: 1.0
is: CHEBI:17336
is: HMDB06217
is: SBO:0000247
name: 9-cis-retinol
constant: false
has only substance units: false
initial amount: NaN

metaM g1m8mpdol L r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: C05870
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_89cf9980_d442_4461_bb30_651abb958bab
type: Species
boundary condition: true
is: Q9NQ66
is: SBO:0000252
name: PLCB1
is encoded by: hsa:23236
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR r1603
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true

metaM 3mob c
boundary condition: false
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
initial concentration: 1.0
is: HMDB00019
has only substance units: false
constant: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
type: Species

metaM o2 r
initial amount: NaN
type: Species
is: HMDB01377
is: CHEBI:15379
has only substance units: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: C00007
name: O2
constant: false
is: SBO:0000247

metaR ALASERNaEx
type: Reaction
kinetic law: MODEL1310110035#
reversible: false
fast: false
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110035#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM i e
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
name: iodide
initial amount: NaN
constant: false
is: CHEBI:16382
type: Species
is: HMDB12238
boundary condition: false
initial concentration: 1.0

metaR r2388
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
is described by: ECO:0000000
type: Reaction

metaM ei11ecoa x
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 11-eicosenoylcoa
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM man g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
name: D-mannose
constant: false
boundary condition: false
has only substance units: false
is: HMDB00169
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_632f1e44_35f5_486b_b59f_6ca334ae9611
has only substance units: false
is encoded by: hsa:117248
is: Q8N3T1
type: Species
name: GALNTL2
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR LDH L
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: L-lactate dehydrogenase
reversible: true
type: Reaction

metaR TYROXDAc
fast: false
reactant: MODEL1310110035#
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.4.3.4

http://identifiers.org/biomodels.db/MODEL1310110035#_bf091265_8a81_4995_b328_bd5974319c73
is encoded by: hsa:4704
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: NDUFA9
is: Q16795
is: SBO:0000252
boundary condition: true

metaR r1602
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
fast: false

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
fast: false
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_9ecea98d_3f41_4de8_89b8_fa09e5e3b11d
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:515
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_cfba8443_1c36_4598_96af_335fe6976793
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:9058
is: SBO:0000252
is: E7ETH5
type: Species
has only substance units: false
name: SLC13A2
initial amount: NaN

metaR VALTAm
fast: false
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110035#
name: valine transaminase, mitochondiral
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_2e836c4b_49ad_4aaf_b289_c6cd7d41380d
has only substance units: false
is: Q08828
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:107
initial amount: NaN
initial concentration: NaN
name: ADCY1
type: Species

metaM tetpent6 e
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
is: HMDB06322

metaR RETI1
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: retinol isomerase (11-cis)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

metaR C160CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
name: C160 transport into the mitochondria
product: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction

metaR PPCOAOm
is: SBO:0000176
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110035#

metaR VALtec
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: L-valine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaR GGT6
name: Gamma-glutamyltransferase
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_2bb3fae9_a735_4877_b77f_6cb4bcbbfad6
boundary condition: true
constant: false
name: MGAT1
initial concentration: NaN
type: Species
is encoded by: hsa:4245
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P26572

metaM thym e
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
initial concentration: 1.0
is: CHEBI:17821
boundary condition: false
is: HMDB00262
has only substance units: false
name: thymine
is: SBO:0000247
initial amount: NaN
constant: false

metaM HC00591 m
is: CHEBI:16769
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 2-oxoglutaramate
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
constant: false
is: SBO:0000247

metaM o2 x
name: O2
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:15379
initial amount: NaN
is: C00007
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: HMDB01377

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR MELATNOX
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.48
kinetic law: MODEL1310110035#
name: Melatonin:NADP oxidoreductase

metaR ACGAMtly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
name: N-acetyl-glucosamine lysosomal efflux
reversible: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_af682a13_ef81_487f_be54_4c3beef64e86
name: SLC43A2
is: Q8N370
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:124935
type: Species
initial concentration: NaN
initial amount: NaN

metaR r2386
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110035#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR r0523
reactant: MODEL1310110035#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reversible: false
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaM hs deg11 l
name: heparan sulfate, degradation product 11
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
is: HMDB00868
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57737
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_1bc87664_6401_4bd8_ac2f_eca45c2daa2c
name: TK2
is: O00142
initial amount: NaN
is encoded by: hsa:7084
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_f5354b56_f8eb_47d3_a54d_710558af6ea4
is: SBO:0000252
has only substance units: false
name: CPT1B
initial amount: NaN
is: Q53FV7
constant: false
is encoded by: hsa:1375
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_c3d82d10_d4c0_4bac_a0f3_5cf75379f880
is: SBO:0000252
name: LDHC
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3948
initial amount: NaN
is: P07864
constant: false
type: Species
has only substance units: false

metaR FAOXC225x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR r1600
fast: false
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg5 l
is: CHEBI:12936
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 5
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r2385
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110035#
reversible: false

metaM ksi deg38 l
initial amount: NaN
type: Species
is: HMDB00143
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
name: keratan sulfate I, degradation product 38

metaR AG13T18g
kinetic law: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
product: MODEL1310110035#
is: SBO:0000176
reversible: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_9671901a_c8a5_4126_b64b_7faf67957f92
type: Species
constant: false
name: _83530_1_c
is: SBO:0000252
is encoded by: hsa:83530
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_85387965_ef85_407c_bbda_fb0314ca77d8
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:277
name: AMY1B
is: P04745

metaR r1825
name: Y+LAT2 Utilized transport
modifier: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
fast: false

metaR MMSAD3m
fast: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
reversible: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.1.27
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is: SBO:0000176

metaR ACOX22x
reversible: false
fast: false
is described by: ECO:0000304
name: acyl-Coenzyme A oxidase 2, branched chain
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.17.99.3
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
modifier: MODEL1310110035#
type: Reaction

metaM ksii core2 pre2 g
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 2
is: SBO:0000247
is: C00130
is: CHEBI:58053
is: HMDB00175
initial amount: NaN

metaR S6T15g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110035#
reversible: false
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaM man c
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00169
is: C00159
type: Species

metaR r0747
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110035#
modifier: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction

metaR GALNTg
reversible: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.41
fast: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
name: GalNAc transferase, Golgi apparatus
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_c08bbca7_38f7_4590_a0dd_c58b6b4975b6
name: GYS2:GYG2
initial amount: NaN
type: Species
has part: P54840
constant: false
is encoded by: hsa:8908
has part: O15488
is encoded by: hsa:2998
is: SBO:0000297
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM pail4p hs n
initial concentration: 1.0
has only substance units: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
initial amount: NaN
constant: false

metaR FAOXC2051843x
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_98e88a44_49ae_42f9_bd8c_751938038e18
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8875
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: VNN2
is: O95498

metaR RAI1
type: Reaction
fast: false
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal isomerase (11-cis)
product: MODEL1310110035#

metaR NDP8
name: nucleoside-diphosphatase (dUDP)
modifier: MODEL1310110035#
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:

metaR r1824
is: SBO:0000185
kinetic law: MODEL1310110035#
name: Y+LAT2 Utilized transport
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM nmn n
has only substance units: false
type: Species
is: CHEBI:14649
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
initial concentration: 1.0
initial amount: NaN
name: NMN(-)

metaR HISTAtu
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
name: Histamine uniport

http://identifiers.org/biomodels.db/MODEL1310110035#_d7bb6352_e8ee_4f1b_b515_053c274a16e6
is: Q9NS18
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51022
name: GLRX2
type: Species
initial amount: NaN

metaM lneldc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: linoelaidic acid (all trans C18:2)
boundary condition: false
is: HMDB06270
type: Species

metaR PHYHx
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.11.18
modifier: MODEL1310110035#
name: Phytanoyl-CoA dioxygenase, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110035#_4fc1cd63_059a_4dd6_a488_172e1b4e7eab
has only substance units: false
is: Q9Y6A2
is: SBO:0000252
is encoded by: hsa:10858
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: CYP46A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9e976f86_c046_43cc_9f19_afe4cf42b0cb
is encoded by: hsa:55350
initial concentration: NaN
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false

metaR RE0569E
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
reactant: MODEL1310110035#
type: Reaction
name: RE0569
modifier: MODEL1310110035#

metaR r0522
reversible: false
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_629361db_2bea_48d7_bcbb_2fe75f910434
is: SBO:0000252
type: Species
is encoded by: hsa:10455
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ECI2
initial amount: NaN
is: O75521
constant: false

metaM m2emgacpail hs r
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:24636
has only substance units: false
initial concentration: 1.0
is: C00080
boundary condition: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR PDE4
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.17
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
reversible: false

metaR GLYtm
reactant: MODEL1310110035#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: glycine passive transport to mitochondria
product: MODEL1310110035#

metaM lnlccrn m
name: Linoleyl carnitine
type: Species
is: HMDB06469
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM HC01115 c
name: NeuNGc
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial amount: NaN
is: CHEBI:29025
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_6ab7e418_749e_4ee6_bd1e_5d3e3a882d04
boundary condition: true
is: Q9NQU1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:65010
name: SLC26A6
is: SBO:0000252

metaM fdp c
is: http://identifiers.org/pubchem.compound/3647
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
boundary condition: false
name: D-Fructose 1,6-bisphosphate
is: C00354
is: CHEBI:16905
type: Species
has only substance units: false
constant: false
is: HMDB01058
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110035#
name: RE1533
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110035#

metaR GCC2cm
reactant: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269

metaR DSAT
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
type: Reaction

metaM 4abut e
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
is: CHEBI:3628
is: SBO:0000247
type: Species
is: C00334
is: HMDB00112
name: 4-Aminobutanoate
initial concentration: 1.0
constant: false
initial amount: NaN

metaR S6TASE10ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110035#

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
is: C01342
is: HMDB00051
boundary condition: false
constant: false
notes: FORMULA: XH CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28938
is: SBO:0000247

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM hx2coa x
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB13037
type: Species
is: C00888
constant: false
has only substance units: false

metaR B3GNT34g
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176

metaM sucsal m
boundary condition: false
is: CHEBI:57706
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
name: Succinic semialdehyde
is: HMDB01259

metaR BCDO
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.14.99.36
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
name: beta-Carotene dioxygenase

metaR r0755
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR PCHOLPm hs
fast: false
kinetic law: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
name: choline phosphatase
is described by: ECO:0000269
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
product: MODEL1310110035#
is: SBO:0000176

metaR S6T13g
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110035#
reversible: false
product: MODEL1310110035#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_67c7604f_09aa_4dcb_9f4c_e341b634bc05
type: Species
name: SLC25A20
has only substance units: false
is encoded by: hsa:788
is: O43772
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR NRVNCt
is: SBO:0000185
product: MODEL1310110035#
reversible: true
type: Reaction
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_2e5addb1_e383_4ad1_9d81_a31767baa15f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: _T83654_1_e
is encoded by: hsa:T83654
boundary condition: true

metaM pail4p hs c
constant: false
is: CHEBI:58178
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR RE2625C
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
reversible: true
name: RE2625
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_0ecc0536_9edd_4bd1_9b58_08212767e3cc
type: Species
boundary condition: true
is: SBO:0000252
name: _C7orf24_1_m
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:C7orf24
initial concentration: NaN

metaR SMPD4
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
name: sphingomyelinase
kinetic law: MODEL1310110035#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is: SBO:0000176
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_d79eb59b_52b6_4b18_8249_572827261fae
initial concentration: NaN
has only substance units: false
name: PIGC
type: Species
boundary condition: true
is: Q92535
is encoded by: hsa:5279
constant: false
initial amount: NaN
is: SBO:0000252

metaM ump r
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
name: UMP
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR AG13T4g
kinetic law: MODEL1310110035#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_097ef431_537e_4620_a25f_da8d27cf5e6a
is: SBO:0000252
name: ENTPD2
is: Q9Y5L3
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:954
has only substance units: false
initial amount: NaN

metaM frdp x
boundary condition: false
initial concentration: 1.0
is: CHEBI:175763
has only substance units: false
is: HMDB00961
is: SBO:0000247
name: farnesyl pyrophosphate(3-)
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM 4abut c
boundary condition: false
name: 4-Aminobutanoate
is: CHEBI:3628
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00334
is: HMDB00112
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0

metaM CE5236 c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
is: CHEBI:28002
type: Species

metaR S6TASE8ly
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110035#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_2e62dfba_adee_4a87_a4e4_d6d13e57be5a
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P23919
is encoded by: hsa:1841
type: Species
initial concentration: NaN
boundary condition: true
name: DTYMK

metaM clpndcoa c
is: HMDB06267
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: clupanodonyl CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d1cc0944_13da_47a8_b349_a8d9a52c1952
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: B4DFS7
is: SBO:0000252
is encoded by: hsa:2530
initial concentration: NaN
name: FUT8

metaM accoa x
is: HMDB01206
is: SBO:0000247
boundary condition: false
name: Acetyl-CoA
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288

http://identifiers.org/biomodels.db/MODEL1310110035#_b000abbf_e600_416d_94bd_2da0f5991c32
is: P08236
initial amount: NaN
name: GUSB
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:2990
initial concentration: NaN
is: SBO:0000252

metaM ncam c
type: Species
is: HMDB01406
notes: FORMULA: C6H6N2O CHARGE: 0
is: CHEBI:0
is: SBO:0000247
boundary condition: false
name: Nicotinamide
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00153

http://identifiers.org/biomodels.db/MODEL1310110035#_946efceb_3069_460f_bab6_3ad113110189
name: LDHD
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:197257
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_e6d73cb6_55ce_4671_a16e_0883602be8a3
constant: false
is encoded by: hsa:3098
initial concentration: NaN
name: HK1
is: SBO:0000252
has only substance units: false
is: A8K7J7
boundary condition: true
initial amount: NaN
type: Species

metaR RE0926E
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
name: RE0926
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_6369d827_8f94_4d31_89ca_af482cdc40c3
type: Species
name: XYLB
has only substance units: false
is: O75191
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9942
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_410df66d_b945_4c03_a34f_e68f43bc61e7
has only substance units: false
is: P09622
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1738
initial amount: NaN
type: Species
initial concentration: NaN
name: DLD

metaM hs deg4 l
initial amount: NaN
name: heparan sulfate, degradation product 4
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
type: Species
boundary condition: false

metaM frdp r
is: CHEBI:175763
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: C00448
name: Farnesyl diphosphate
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00961
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_d6ccecb2_f462_4ac0_96f2_a812922508e4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4830
type: Species
boundary condition: true
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110035#_31cfbd30_e855_440d_8c46_37900f632cb5
is: P54819
is encoded by: hsa:204
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: AK2
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7e5404e8_2cd3_4b0b_9da2_bf795642925d
initial concentration: NaN
has only substance units: false
is: Q16836
type: Species
is encoded by: hsa:3033
constant: false
name: HADH
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM accoa r
is: SBO:0000247
boundary condition: false
constant: false
name: acetyl-CoA(4-)
is: HMDB01206
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN

metaM dag hs r
name: diglyceride
constant: false
initial amount: NaN
is: CHEBI:18035
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB03426
name: pantetheine
is: CHEBI:16753
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_0611a53b_85e9_4e49_949a_2b8de8a56480
initial concentration: NaN
is: Q9Y6K8
is encoded by: hsa:26289
name: AK5
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_67c60a31_0646_4fd4_9ae0_d253f00b180a
has part: Q9NY65
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1962
boundary condition: true
name: EHHADH:ACAA1:ACOX1
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110035#_1545426f_e4b3_41c7_9bf4_283020d0d050
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI926493
name: _AI926493_1_m
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaR r0752
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reactant: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110035#
reversible: true
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_cc88e4ac_b1a5_419d_900a_dbc2fa13a21e
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PAPSS1
has only substance units: false
is encoded by: hsa:9061
is: O43252
constant: false

metaR G14T3g
reversible: false
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR CRNCARtp
is: SBO:0000185
product: MODEL1310110035#
reversible: false
name: carnitine-acetylcarnitine carrier, peroxisomal
fast: false
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM o2 m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01377
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
name: O2
is: CHEBI:15379

metaR DOLPMT4 Ler
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
fast: false

metaR PSSA1 hs
type: Reaction
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
name: Phosphatidylserine synthase homo sapiens
is: SBO:0000176
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.8.29
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_cf36b0fb_388e_4ae9_a811_70a454754ab2
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: SLC8A3
is encoded by: hsa:6547
initial amount: NaN
has only substance units: false

metaR DNDPt36m
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
name: dGDP transport via dCDP antiport
reactant: MODEL1310110035#
type: Reaction
fast: false

metaM ncam e
is: CHEBI:0
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H6N2O CHARGE: 0
initial amount: NaN
boundary condition: false
is: HMDB01406
name: Nicotinamide
is: C00153
constant: false
has only substance units: false

metaM hestratriol r
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: 4,17 dihydroxy estradiol
is: SBO:0000247
is: HMDB05896
type: Species
initial concentration: 1.0

metaR PHCDm
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
type: Reaction
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000304
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
is: SBO:0000176

metaM malthx e
type: Species
boundary condition: false
constant: false
is: C01936
has only substance units: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
name: Maltohexaose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_94de7f2d_adc2_459a_88ed_1f6bf91e29a1
is: SBO:0000252
type: Species
constant: false
name: ALDH7A1
boundary condition: true
initial amount: NaN
is: E7EPT3
has only substance units: false
is encoded by: hsa:501
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_533db03a_2335_43dd_be29_0fcbff475300
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: _AI694761_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI694761

http://identifiers.org/biomodels.db/MODEL1310110035#_dd526636_37d6_4e48_86f9_b55c2c356625
has only substance units: false
is: E9PCI1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: ACP2
type: Species
is encoded by: hsa:53

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110035#_912f346f_94e2_4179_9ddb_99d10f0d6ae9
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: RPIA
is encoded by: hsa:22934
is: P49247
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_114cc63c_c5a8_40b7_ac37_5b0b37f777c2
boundary condition: true
is encoded by: hsa:8639
name: AOC3
is: Q16853
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaM hspg l
boundary condition: false
is: CHEBI:17899
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
name: heparan sulfate proteoglycan
is: HMDB01993
initial amount: NaN

metaR SO4CLtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: sulfate transport via chloride countertransport (2:1)
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000304
reversible: false
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f015be9a_3fe3_41ef_bc19_a89bc982852b
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q7LGC8
has only substance units: false
is encoded by: hsa:9469
boundary condition: true
name: CHST3
constant: false

metaR r1050
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
reversible: true

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247
name: R total Coenzyme A
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_a0cb21b3_facf_4f92_b2a6_555b8c1a6fa3
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: E7EQF2
is: SBO:0000252
has only substance units: false
name: CROT
is encoded by: hsa:54677

http://identifiers.org/biomodels.db/MODEL1310110035#_a5f147c9_4528_4bff_8f53_c86820aa0af1
name: TRNT1
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:51095
is: Q96Q11
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi pre11 g
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 11
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C129H208N9O101S3X CHARGE: -4

metaM trdrd c
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
has only substance units: false
is: CHEBI:15967
initial concentration: 1.0
is: SBO:0000247
is: C00342
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR r0753
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110035#

metaR r1051
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR GLYBtm
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
reactant: MODEL1310110035#
type: Reaction

metaM ksi pre10 g
constant: false
initial amount: NaN
is: HMDB00175
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 10
is: C00130

metaM ksii core2 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00175
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: C00130
is: CHEBI:58053

metaR SGPL12r
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Sphingosine-1-phosphate lyase
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110035#
is: SBO:0000176

metaM 3hexdtetcoa x
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02288
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_56d46cdf_93f9_4d07_b7a5_9ae88d2cdae5
type: Species
initial concentration: NaN
is encoded by: hsa:4191
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P40926
boundary condition: true
constant: false
name: MDH2

metaR LYStiDF
kinetic law: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
name: L-lysine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000269

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
fast: false

metaR GPDDA1
is: SBO:0000176
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110035#_9c2ed842_8412_44f1_ab03_10c2846b4369
initial concentration: NaN
name: NDUFS4
constant: false
has only substance units: false
is encoded by: hsa:4724
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: O43181

http://identifiers.org/biomodels.db/MODEL1310110035#_7c4865c1_8d21_4ca1_8222_52be689e19a0
initial amount: NaN
constant: false
has only substance units: false
name: SLC38A4
is: Q969I6
boundary condition: true
is encoded by: hsa:55089
is: SBO:0000252
type: Species
initial concentration: NaN

metaM accoa n
initial concentration: 1.0
is: CHEBI:57288
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: HMDB01206
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_1bb723fb_4838_4933_9e13_4b5020f358f9
has only substance units: false
constant: false
boundary condition: true
is: P51841
initial concentration: NaN
is encoded by: hsa:2986
type: Species
is: SBO:0000252
name: GUCY2F
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_31401d36_dd4c_44d2_a9fc_7083dfeda1ca
boundary condition: true
is encoded by: hsa:6817
is: SBO:0000252
constant: false
name: SULT1A1
initial amount: NaN
is: P50225
has only substance units: false
type: Species
initial concentration: NaN

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR GTHRDt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
name: Glutathione transport into mitochondria

metaM dcsptn1crn c
boundary condition: false
has only substance units: false
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
type: Species

metaM mpdol L c
boundary condition: false
type: Species
is: CHEBI:18396
is: SBO:0000247
constant: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1

metaR r0962
product: MODEL1310110035#
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_8702d0a0_abeb_4ffc_81e7_0b85d98a194c
is: SBO:0000252
has only substance units: false
is: P23434
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2653
boundary condition: true
constant: false
name: GCSH

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
name: aspartate intake by system ASCT-1 transporter
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b9eda586_7fa9_4c92_97d3_4802bf9bfb37
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9Y4K0
name: LOXL2
is encoded by: hsa:4017
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0815154f_b8f7_4542_84ca_8186d3d322b4
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q96RN1
name: SLC26A8
initial amount: NaN
is encoded by: hsa:116369

metaM lgnc e
is: CHEBI:31014
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
has only substance units: false
type: Species
boundary condition: false
is: HMDB02003
constant: false
name: lignocerate
is: SBO:0000247

metaR FUT911g
reversible: false
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
kinetic law: MODEL1310110035#
name: Alpha-(1,3)-fucosyltransferase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.152
product: MODEL1310110035#

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reversible: true
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
name: Hypoxanthine transport
modifier: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM accoa m
is: SBO:0000247
name: Acetyl-CoA
is: HMDB01206
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: CHEBI:57288
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_cbd6991a_daf3_4281_9e52_0d66651dae9f
type: Species
initial concentration: NaN
name: ATP2B4
is: SBO:0000252
initial amount: NaN
is: P23634
constant: false
is encoded by: hsa:493
has only substance units: false
boundary condition: true

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaM 3hpp m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16510
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
name: 3-hydroxypropionate
is: HMDB00700
constant: false
type: Species
boundary condition: false

metaM ump m
initial amount: NaN
is: CHEBI:57865
constant: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: HMDB00288
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_5dab66fa_d075_4a6f_89f8_73ed1c7d1d78
type: Species
is encoded by: hsa:8833
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: P49915
name: GMPS

http://identifiers.org/biomodels.db/MODEL1310110035#_33188e65_1c71_4250_b2e9_482011d32ae1
initial concentration: NaN
is: SBO:0000252
name: MAN2A2
initial amount: NaN
is encoded by: hsa:4122
constant: false
boundary condition: true
has only substance units: false
type: Species
is: Q9P1E4

http://identifiers.org/biomodels.db/MODEL1310110035#_27966dea_a746_4896_b3dc_000d226d7b8c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACSL4
boundary condition: true
is: Q5JWV8
is encoded by: hsa:2182

metaR NMNtn
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110035#
name: NMN transport, nuclear trhough pore
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM hestratriol e
initial concentration: 1.0
name: 4,17 dihydroxy estradiol
is: SBO:0000247
type: Species
is: HMDB05896
boundary condition: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
initial amount: NaN
has only substance units: false

metaM sql r
name: squalene
initial concentration: 1.0
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:15440
is: HMDB00256
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_6a8bfea4_4e9e_4708_8f7a_a999d1808ecd
type: Species
is encoded by: hsa:5298
initial amount: NaN
has only substance units: false
name: PI4KB
boundary condition: true
is: Q9UBF8
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r0750
fast: false
product: MODEL1310110035#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000

metaR CERT1rt
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110035#
name: ceramide transport protein
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110035#
reversible: true

metaR NACHEX3ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_2540af59_b3dc_4270_bc43_f6db729f5f08
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6697
name: SPR
initial concentration: NaN
constant: false
boundary condition: true
is: P35270

metaR COAtm
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
name: CoA transporter
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110035#
fast: false
reversible: true
modifier: MODEL1310110035#

metaR TDCHOLAtx
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
name: bile acid intracellular transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110035#

metaM lgnc c
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
constant: false
name: lignocerate
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:31014
type: Species
is: HMDB02003

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_cdcde94e_4acb_4bfa_8517_a1e10a8c3695
name: GSR
is: P00390
is: SBO:0000252
is encoded by: hsa:2936
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaM paf hs e
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:36707
initial amount: NaN
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
has only substance units: false

metaR RE3243R
reactant: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
fast: false
name: RE3243
product: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:

metaR GUACYC
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.6.1.2
name: guanylate cyclase
type: Reaction
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_0defff10_5a03_44b3_905c_b27bbbf8f97b
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ACAT2
is encoded by: hsa:39
boundary condition: true
initial amount: NaN
is: Q9BWD1

metaM 3octdectecoa x
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_2764d47d_c886_42fe_b1b5_b970bb31b499
boundary condition: true
is: Q96CA6
type: Species
is: SBO:0000252
name: ACAA1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:30
has only substance units: false

metaM ksii core4 pre2 g
initial amount: NaN
has only substance units: false
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
name: keratan sulfate II boisynthesis, precursor 2
initial concentration: 1.0
type: Species
is: C00130
is: HMDB00175
constant: false

metaR Q10H2e
fast: false
is: SBO:0000185
is described by: ECO:0000134
name: transport of ubiquinol into lymph
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: true

metaR ASAH1
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
name: N-acylsphingosine amidohydrolase
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.23
product: MODEL1310110035#
reversible: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_bb68e79e_14af_4a51_82be_28d12a5f894e
is encoded by: hsa:2618
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: GART
type: Species
has only substance units: false
is: P22102

metaM o2 c
initial amount: NaN
type: Species
is: CHEBI:15379
has only substance units: false
is: HMDB01377
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
name: O2
constant: false
is: SBO:0000247

metaM hestratriol c
is: SBO:0000247
name: 4,17 dihydroxy estradiol
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_094d794e_523b_436c_89d0_bf3771624e4e
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: Q9UF12
has only substance units: false
is encoded by: hsa:58510
name: PRODH2
type: Species
is: SBO:0000252

metaM anth e
type: Species
initial amount: NaN
is: HMDB01123
constant: false
boundary condition: false
initial concentration: 1.0
name: anthranilate
is: CHEBI:16567
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

metaR COAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
fast: false
name: CoA transport in Golgi via diffusion
reactant: MODEL1310110035#
is described by: ECO:0000000

metaM creat e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16919
name: creatine
boundary condition: false
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
constant: false
has only substance units: false

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110035#
name: fatty-acid--CoA ligase (tetradecanoate)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
type: Reaction
fast: false
reactant: MODEL1310110035#
reversible: false

metaR PTE3x
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110035#
name: peroxisomal acyl-CoA thioesterase

http://identifiers.org/biomodels.db/MODEL1310110035#_8a62167e_9565_4ef7_be2e_c5c79163d441
is: SBO:0000252
is: P49448
type: Species
is encoded by: hsa:2747
name: GLUD2
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM uppg3 c
constant: false
initial concentration: 1.0
initial amount: NaN
is: C01051
type: Species
is: CHEBI:57308
boundary condition: false
name: Uroporphyrinogen III
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
is: HMDB01086
has only substance units: false
is: SBO:0000247

metaR RE3421R
name: RE3421
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000
fast: false

metaR r0226
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
fast: false
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176

metaM homoval m
is: CHEBI:545959
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial amount: NaN
name: Homovanillate
is: HMDB00118

http://identifiers.org/biomodels.db/MODEL1310110035#_20ee4885_8ca5_452e_a4fd_f3db6f1afd9d
constant: false
boundary condition: true
name: VNN3:VNN2:VNN1
type: Species
is encoded by: hsa:8876
is encoded by: hsa:55350
is encoded by: hsa:8875
has only substance units: false
has part: O95497
initial concentration: NaN
initial amount: NaN
has part: A8K7W0
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110035#_c6a3bdfe_2662_4108_93f4_9aa5c8075dae
is: SBO:0000252
constant: false
is: F8W1L5
initial amount: NaN
name: GPD1
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2819

metaM o2 e
is: CHEBI:15379
has only substance units: false
is: C00007
is: HMDB01377
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_663be7e5_7fb5_4e31_b319_742724f4c4f0
constant: false
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ST3GAL3
boundary condition: true
type: Species

metaR PDE1
modifier: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.17
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3386c675_d4e7_4db9_8053_9a0a362ffc68
is encoded by: hsa:26266
type: Species
constant: false
name: SLC13A4
is: SBO:0000252
initial amount: NaN
is: Q9UKG4
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM 2hexdtricoa x
type: Species
has only substance units: false
boundary condition: false
is: HMDB02288
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa

metaR BALAPAT1tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

metaM hspg e
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: heparan sulfate proteoglycan
is: HMDB02259
boundary condition: false
is: CHEBI:32366
constant: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
type: Species

metaM btn c
is: SBO:0000247
initial amount: NaN
is: C00120
type: Species
constant: false
boundary condition: false
is: CHEBI:3420
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
name: Biotin
has only substance units: false

metaM acgal1p c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB06480
name: N-Acetyl-D-galactosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
boundary condition: false
is: CHEBI:55404
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_6617257a_66d0_46db_ab54_f2ad7bf17c87
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR FAOXC226m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR PPAm
reversible: false
product: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
name: inorganic diphosphatase
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fefbd48f_8aab_442e_8578_e5f45653ed5a
constant: false
is: SBO:0000252
boundary condition: true
is: O43272
initial amount: NaN
type: Species
is encoded by: hsa:5625
has only substance units: false
name: PRODH
initial concentration: NaN

metaM acglcgalgluside hs g
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
is: CHEBI:17103
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR r0960
reactant: MODEL1310110035#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110035#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaM 5dpmev c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01090
has only substance units: false
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
type: Species
boundary condition: false
constant: false

metaR UREAt5
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
name: urea, water cotransport
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269
modifier: MODEL1310110035#
fast: false

metaM creat c
constant: false
initial concentration: 1.0
initial amount: NaN
name: creatine
is: SBO:0000247
is: CHEBI:16919
boundary condition: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
has only substance units: false
is: HMDB00064

metaM CE2417 m
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123

metaR NACHEX12ly
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM anth c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16567
is: SBO:0000247
name: anthranilate
is: HMDB01123
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
boundary condition: false

metaM ump n
boundary condition: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
type: Species
name: UMP(2-)
has only substance units: false
is: CHEBI:57865
initial amount: NaN
is: SBO:0000247
constant: false

metaR 3MOPte
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxopentanoate
is: SBO:0000185
fast: false
product: MODEL1310110035#
type: Reaction

metaR DESAT22 1p
reactant: MODEL1310110035#
type: Reaction
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM memgacpail hs r
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:15809
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_f4f4f129_8ad9_4a64_ac59_cff09a21041b
is: Q6FHI7
initial amount: NaN
name: CA4
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:762
boundary condition: true
constant: false

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
kinetic law: MODEL1310110035#
fast: false
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110035#_b3d1d04a_4ca5_4f50_af07_e1691ec2ea1b
boundary condition: true
is: H0YMZ7
initial amount: NaN
is encoded by: hsa:5151
name: PDE8A
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR ABO9g
reversible: false
modifier: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
kinetic law: MODEL1310110035#
is described by: ECO:0000269
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

http://identifiers.org/biomodels.db/MODEL1310110035#_1a624a84_855c_4dbb_82f4_8a6147127ab1
initial amount: NaN
constant: false
boundary condition: true
is: O75387
is encoded by: hsa:8501
is: SBO:0000252
has only substance units: false
type: Species
name: SLC43A1
initial concentration: NaN

metaR GLYtp
fast: false
name: glycine passive transport to peroxisome
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

metaR LTA4H
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.3.2.6
name: Leukotriene A-4 hydrolase
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
fast: false
product: MODEL1310110035#
is: SBO:0000176

metaR RETH2e
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
name: retinyl ester hydrolase (11-cis), extracellular

http://identifiers.org/biomodels.db/MODEL1310110035#_8752b811_1cce_40c5_988e_316e1846b294
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM btn e
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
is: C00120
type: Species
constant: false
boundary condition: false
is: CHEBI:3420
is: SBO:0000247
is: HMDB00030
initial concentration: 1.0
initial amount: NaN

metaR r0450
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
fast: false
modifier: MODEL1310110035#
is described by: ECO:0000000
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
is: CHEBI:58280
name: IDP(3-)
type: Species
is: HMDB03335
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_673a05e3_8dd3_480a_950d_b38de6e7bf15
type: Species
is encoded by: hsa:10396
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ATP8A1
initial concentration: NaN
is: Q9Y2Q0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_701cd07d_cc75_4f0d_935c_fd66b746c542
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q9NY64
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29988
name: SLC2A8

metaM ump e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: UMP(2-)
boundary condition: false
is: CHEBI:57865
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: HMDB00288

http://identifiers.org/biomodels.db/MODEL1310110035#_c9520fce_954d_43bf_bab2_7a053c619091
is encoded by: hsa:5291
name: PIK3CB:PIK3R1
has part: B4DER4
is: SBO:0000297
is encoded by: hsa:5295
initial amount: NaN
initial concentration: NaN
type: Species
has part: B3KT19
boundary condition: true
has only substance units: false
constant: false

metaR r0642
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false

metaM 5thf e
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06487
name: pentaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110035#_491478e6_4d6e_4b19_bf20_3b65d3e9c1b8
is encoded by: hsa:8875
initial amount: NaN
is: SBO:0000252
name: VNN2
is: A8K7W0
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_4d373c1a_77fe_425d_871a_abde4eb93754
name: SPTLC1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10558
has only substance units: false
constant: false
is: O15269
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_bb00b575_f41c_4602_abe0_19dbbf60757a
boundary condition: true
is: SBO:0000252
has only substance units: false
name: GCNT2
constant: false
is encoded by: hsa:2651
initial concentration: NaN
initial amount: NaN
is: Q08M29
type: Species

metaR P45027A14m
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1

metaM hs deg10 l
is: HMDB00127
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
constant: false
is: CHEBI:15748
initial amount: NaN
name: heparan sulfate, degradation product 10
is: SBO:0000247
type: Species

metaR r0643
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110035#

metaM ksi deg32 l
name: keratan sulfate I, degradation product 32
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: CHEBI:12936
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110035#_f4fe7315_bbe9_441b_b0d3_94f4e7c78697
type: Species
name: ZADH2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q8N4Q0
is encoded by: hsa:284273
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_299b1656_66f4_490d_8f3f_25d4cc6a6c52
constant: false
has part: P00326
name: ADH1B:ADH1C
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
is encoded by: hsa:126

http://identifiers.org/biomodels.db/MODEL1310110035#_4d2428c0_b463_4ef6_b228_9acf9f27ab11
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
name: PDE9A
constant: false
type: Species
boundary condition: true

metaM trdrd m
is: CHEBI:15967
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Reduced thioredoxin
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_06106373_e596_4a85_892a_a6809f930aa4
is: Q9P212
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PLCE1
is encoded by: hsa:51196
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_52fbeee4_8f98_4d7e_87ff_e5b0d90f2b7f
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23563
constant: false
initial amount: NaN
boundary condition: true
name: CHST5
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_081ee693_d2c1_4df0_93eb_e558b5dd00b8
is: P56181
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4731
name: NDUFV3
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM 3hmbcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
type: Species
has only substance units: false
initial amount: NaN
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57312

metaM idp c
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
type: Species
initial amount: NaN
is: CHEBI:58280
boundary condition: false
is: HMDB03335
has only substance units: false
initial concentration: 1.0

metaM tchola e
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: taurocholic acid
constant: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_65bd6d18_ffbf_4e49_87a5_08fd86ccbcc9
initial concentration: NaN
name: GPX4
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2879
is: SBO:0000252
is: P36969

metaM ump c
type: Species
is: HMDB00288
initial concentration: 1.0
boundary condition: false
is: CHEBI:57865
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
initial amount: NaN
name: UMP
is: SBO:0000247
has only substance units: false

metaR r0644
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR NADtx
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110035#
name: transport of NAD into peroxisome
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110035#

metaR DOPASULT
reversible: false
name: Dopamine Sulfotransferase
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR NDPK10
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
product: MODEL1310110035#
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM xol24oh r
initial concentration: 1.0
is: HMDB01419
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
name: (24S)-24-hydroxycholesterol
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:34310
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_48cdf83e_bc13_4be2_8764_28f4fd5c916e
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PDE9A
type: Species
is encoded by: hsa:5152
constant: false
initial amount: NaN

metaM pan4p m
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01416
type: Species
name: pantetheine 4'-phosphate(2-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:47942
has only substance units: false

metaR AG13T17g
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reversible: false

metaR DPCOAK
type: Reaction
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
kinetic law: MODEL1310110035#
is: SBO:0000176
name: dephospho-CoA kinase
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false

metaR r0531
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_6466abcd_97cd_4e2e_97bf_ff1d8e21410e
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q13510
is encoded by: hsa:427
initial amount: NaN
name: ASAH1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_867e0246_6f9c_434e_a309_68d054a55023
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:514
constant: false
has only substance units: false
type: Species
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110035#_bded908e_deee_40cd_8244_a9c3a8649d79
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10568
has only substance units: false
type: Species
name: SLC34A2
is: SBO:0000252
is: O95436

metaR S6T7g
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110035#
reversible: false
fast: false
product: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

metaR GLCNACASE3ly
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110035#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_10553715_9870_4d9f_a81b_b37da53f63db
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:124583
initial concentration: NaN
name: CANT1
boundary condition: true
is: Q8WVQ1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d32d35ee_eaa0_4885_a52d_92e13e4c7dd3
constant: false
is encoded by: hsa:6584
is: O76082
initial amount: NaN
has only substance units: false
name: SLC22A5
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_08aee5f1_e4ce_415a_9d30_ab73902b5a63
constant: false
is: P25092
boundary condition: true
has only substance units: false
type: Species
name: GUCY2C
initial concentration: NaN
is encoded by: hsa:2984
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_287a1c16_a8da_4697_b3b6_dbe5d029690a
name: ACOX1
is: B4DK61
is: SBO:0000252
constant: false
is encoded by: hsa:51
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_0d53b056_f2de_4d4d_9058_676a722781ba
is: SBO:0000252
is: Q9BT22
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:56052
initial concentration: NaN
name: ALG1

metaM itaccoa m
type: Species
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57381
is: HMDB03377
name: itaconyl-CoA(5-)

metaM m1mpdol L c
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1

metaR 4MPTNLtm
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reversible: true
reactant: MODEL1310110035#
name: 4-methylpentanal transport (mitochondria)
product: MODEL1310110035#
fast: false

metaM pac c
is: CHEBI:18401
is: SBO:0000247
type: Species
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: phenylacetate
constant: false
is: HMDB00209

http://identifiers.org/biomodels.db/MODEL1310110035#_131a3b54_bf3f_46cd_bf5d_18b407886c33
is: SBO:0000252
name: NDUFA4
is encoded by: hsa:4697
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: O00483

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaM frdp c
is: CHEBI:175763
type: Species
name: Farnesyl diphosphate
has only substance units: false
constant: false
is: C00448
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: SBO:0000247
initial concentration: 1.0

metaR RE0830N
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110035#
fast: false
type: Reaction
name: RE0830
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_7c6cf6b1_71e1_4476_9847_d983ffe1a9c6
constant: false
is encoded by: hsa:4718
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFC2
is: SBO:0000252
has only substance units: false
type: Species
is: Q549M5

metaR O2ter
product: MODEL1310110035#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: O2 transport, endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaR r0647
name: Spontaneous reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
kinetic law: MODEL1310110035#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true

metaR r2379
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110035#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#

metaR PPAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: Propionate transport, diffusion
reactant: MODEL1310110035#
is: SBO:0000185

metaR DOLPMT1 Ler
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_12412d97_1138_4fc7_af62_a38b73a21124
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6713
initial concentration: NaN
boundary condition: true
is: Q5HYI4
type: Species
initial amount: NaN
name: SQLE

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0925ecee_db25_4730_96ed_d50a739e05fa
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2629
initial concentration: NaN
has only substance units: false
name: GBA
type: Species
constant: false
is: B7Z6S9

http://identifiers.org/biomodels.db/MODEL1310110035#_2f667997_7ebc_49a3_b091_1a475273760a
constant: false
name: CYP8B1
boundary condition: true
has only substance units: false
is encoded by: hsa:1582
is: Q9UNU6
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM dttp e
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
has only substance units: false
name: dTTP(4-)
initial amount: NaN
boundary condition: false
is: HMDB01342
is: CHEBI:37568

metaR DDPGAm
reversible: true
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD

metaM btn m
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
initial concentration: 1.0
is: CHEBI:57586
initial amount: NaN
name: biotinate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_99964099_230e_4d26_a366_ea997dc172c8
type: Species
is: SBO:0000252
is encoded by: hsa:J03866
has only substance units: false
constant: false
initial concentration: NaN
name: _J03866_1_m
initial amount: NaN
boundary condition: true

metaM ump g
is: HMDB00288
name: UMP(2-)
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
is: CHEBI:57865
constant: false
has only substance units: false

metaM 4izp c
is: SBO:0000247
has only substance units: false
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 4-Imidazolone-5-propanoate
type: Species
is: HMDB01014

metaM hs deg1 l
is: HMDB06210
has only substance units: false
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
name: heparan sulfate, degradation product 1
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_eacc0096_88b8_4a89_b084_9c2bd6dc6ee3
constant: false
name: PRDX2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:7001

http://identifiers.org/biomodels.db/MODEL1310110035#_83add2ba_297b_43d3_94c6_44613db896a1
is: SBO:0000252
has only substance units: false
is: Q9NTN3
type: Species
name: SLC35D1
constant: false
is encoded by: hsa:23169
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR GLNtN1
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
name: Glutamine transport (Na, H coupled)
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

http://identifiers.org/biomodels.db/MODEL1310110035#_be46693e_f9b2_4b8c_adc4_09f1d12aa279
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:226
constant: false
name: ALDOA
boundary condition: true
initial concentration: NaN

metaM xoldiolone c
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:28477
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: HMDB02197
constant: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_6e1fb1c2_8f5c_4c44_90fa_581fa714bf17
is encoded by: hsa:2109
has part: P38117
name: ETFA:ETFB
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000297
type: Species
initial amount: NaN
has only substance units: false

metaR DCMPDA
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.12
is described by: ECO:0000254
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
name: dCMP deaminase
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#

metaM 2hexdtricoa m
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
is: HMDB02288
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_f5784015_5a2b_4f33_9c46_46b45e829c3d
is: P10746
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:7390
name: UROS
initial concentration: NaN

metaM dttp c
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: SBO:0000247
is: C00459
initial amount: NaN
type: Species
name: dTTP
is: HMDB01342

metaM core6 l
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: Core 6
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110035#_db6ca0b2_92cd_407e_8513_f2c0b1eb9c2e
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: P11182
is encoded by: hsa:1629
initial amount: NaN
boundary condition: true
name: DBT
is: SBO:0000252

metaR P4501B1r
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
is described by: ECO:0000269
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
name: cytochrome P450 1B1
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.14.1
reversible: false

metaM lnlccrn c
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
name: Linoleyl carnitine

metaM ocde9ecoa x
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 9-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
constant: false

metaM HC00695 m
is: CHEBI:17432
is: SBO:0000247
constant: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
initial amount: NaN
name: S-Succinyldihydrolipoamide
has only substance units: false
type: Species
boundary condition: false

metaM chsterol e
type: Species
initial amount: NaN
is: CHEBI:16113
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
is: HMDB00067
has only substance units: false
name: cholesterol
constant: false

metaM cholcoaone x
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891
has only substance units: false
is: CHEBI:58507

metaM zymstnl r
is: CHEBI:16608
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
is: HMDB06841
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR GLCNACASE4ly
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR r2376
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_824f4060_13ca_49a8_aba1_a3699c7c0d58
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:10991
initial concentration: NaN
name: SLC38A3
has only substance units: false
constant: false
is: Q99624
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_8768168e_7e27_408b_a34b_ef63d2ba52e6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q8TE04
boundary condition: true
name: PANK1
is encoded by: hsa:53354

metaR RE0830C
type: Reaction
name: RE0830
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#
reversible: true

metaR TDCHOLAte
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false

metaR G3PD2m
reversible: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
is version of: http://identifiers.org/ec-code/1.1.5.3
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110035#

metaR PRPPS
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
fast: false
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
name: phosphoribosylpyrophosphate synthetase

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM HC02202 e
is: CHEBI:57398
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: prostaglandin A1(1-)

metaM chsterol c
initial amount: NaN
constant: false
type: Species
is: HMDB00067
initial concentration: 1.0
is: SBO:0000247
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: CHEBI:16113

metaM 4abut m
type: Species
name: 4-Aminobutanoate
boundary condition: false
is: HMDB00112
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: CHEBI:16865
is: C00334
has only substance units: false
initial amount: NaN

metaR r2375
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_eaa1f251_d3da_45ba_8110_d157042457db
initial amount: NaN
is: P11310
name: ACADM
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:34
constant: false
boundary condition: true

metaR RE2625M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110035#
product: MODEL1310110035#
name: RE2625
is: SBO:0000176
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_38e621ea_9ff2_4bc1_b573_57d2d79348dc
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: HADH
constant: false
initial concentration: NaN
is: Q16836
initial amount: NaN
is encoded by: hsa:3033

http://identifiers.org/biomodels.db/MODEL1310110035#_9bd3feba_47c7_4826_8cdf_11a7b68dbf08
is encoded by: hsa:3938
name: LCT
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: P09848
initial amount: NaN
constant: false
has only substance units: false

metaR SERCYSNaEx
reversible: false
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110035#
is described by: ECO:0000269
modifier: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)

metaR LEUt4
reactant: MODEL1310110035#
name: L-leucine transport in via sodium symport
modifier: MODEL1310110035#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
fast: false

metaM ins e
is: C00294
initial amount: NaN
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: CHEBI:17596
constant: false
has only substance units: false
is: HMDB00195
is: SBO:0000247
boundary condition: false
type: Species

metaR FACOAL246 1
product: MODEL1310110035#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_02859ae4_bafc_47b5_92cb_ad575a9cb341
initial amount: NaN
type: Species
constant: false
has part: P33402
has part: Q02153
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2977
is: SBO:0000297
is encoded by: hsa:2983
name: GUCY1A2:GUCY1B3

metaM ksii core2 deg8 l
notes: FORMULA: C36H60N3O25X CHARGE: 0
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
is: HMDB00143

metaR r2378
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR r0539
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
fast: false
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000000
reversible: true

metaM Ser Thr l
has only substance units: false
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
constant: false
is: CHEBI:58190
type: Species
boundary condition: false
is: HMDB00224
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_4b67d400_906f_474f_a230_9312c7d7c18b
boundary condition: true
name: _BE966236_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:BE966236
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_d941f6fa_f247_4290_941c_cb7a796df9b8
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57835
boundary condition: true
constant: false
initial concentration: NaN
name: SLC4A5
has only substance units: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR ASPTA
is: SBO:0000176
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
name: aspartate transaminase
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaR r2377
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_b10422ba_164f_4968_b1d4_5853f3bb07e5
constant: false
is encoded by: hsa:5136
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9Y633
type: Species
initial amount: NaN
is: SBO:0000252
name: PDE1A

http://identifiers.org/biomodels.db/MODEL1310110035#_cadc8b99_09f6_4c6a_b8fa_d46bf4d52787
type: Species
is encoded by: hsa:6185
initial concentration: NaN
is: SBO:0000252
is: P04844
has only substance units: false
name: RPN2
initial amount: NaN
constant: false
boundary condition: true

metaM ksi deg2 l
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
name: keratan sulfate I, degradation product 2
type: Species
constant: false
boundary condition: false
is: HMDB00573
is: SBO:0000247
is: CHEBI:30825
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM ins c
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
name: Inosine
is: HMDB00195
initial amount: NaN
type: Species
is: CHEBI:17596
is: C00294
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4539f0a2_12d4_492e_88cc_81d3f967845e
type: Species
boundary condition: true
name: ACOX1
is: SBO:0000252
is encoded by: hsa:51
constant: false
is: Q15067
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_9ca545e2_4d35_47c6_b558_890bc4fc80c0
type: Species
is encoded by: hsa:84076
name: TKTL2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: Q9H0I9
initial amount: NaN

metaM thyox L e
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: L-thyroxine
is: CHEBI:18332
has only substance units: false

metaR 4MPTNLte
fast: false
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: 4-methylpentanal transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_aa591a27_f826_4c8f_bcd1_51783deecd35
is: Q99884
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC6A7
is encoded by: hsa:6534
has only substance units: false

metaM clpn hs c
type: Species
constant: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
is: SBO:0000247
name: cardiolipin
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28494

metaR r2372
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
name: taurocholic acid
is: HMDB00036
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:36257
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR GLCNACASE1ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
reversible: false

metaR DCSPTN1COAtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
reversible: true

metaM ksi pre33 g
constant: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 33
boundary condition: false
is: SBO:0000247
is: C00130
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
type: Species
is: HMDB00175

metaR RE0691C
fast: false
is described by: ECO:0000000
name: RE0691
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_45eb62ab_b90a_454a_a3ff_7f2afe2ad5f4
initial amount: NaN
type: Species
is: Q9UBK5
constant: false
is: SBO:0000252
boundary condition: true
name: HCST
has only substance units: false
is encoded by: hsa:10870
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_05cc1462_8620_43f4_8c99_c5f0771c3dfe
has part: Q07326
initial amount: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:5281
type: Species
is encoded by: hsa:84720
boundary condition: true
has part: Q8TEQ8
name: PIGF:PIGO
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3bff5660_da43_4a21_9467_c0b73e6d4a7c
is: Q9UBM1
is encoded by: hsa:10400
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PEMT

metaR r1911
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_970f204c_11b9_4acd_84b7_770fa1cc7e17
initial amount: NaN
name: FLAD1
constant: false
is: Q8NFF5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:80308
type: Species

metaR r2371
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_f1a6db8f_a5b1_406c_80d9_ad1f1f48e835
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:641372
initial amount: NaN
is: Q3I5F7
name: ACOT6
initial concentration: NaN
has only substance units: false

metaR r1815
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false

metaR CITL
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Citrate lyase
is: SBO:0000176
type: Reaction

metaR SMPD3g
product: MODEL1310110035#
is: SBO:0000176
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110035#
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is version of: http://identifiers.org/ec-code/3.1.4.12

metaM dsmsterol r
is: CHEBI:17737
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
has only substance units: false
name: desmosterol
is: HMDB02719

metaM b2coa m
type: Species
constant: false
is: SBO:0000247
is: HMDB02009
boundary condition: false
initial amount: NaN
name: crotonoyl-CoA(4-)
is: CHEBI:57332
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial concentration: 1.0

metaM dhcholoylcoa x
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06895
has only substance units: false
constant: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27393
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false

metaR r2374
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR r0002
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reversible: true
product: MODEL1310110035#
fast: false
name: Active transport
kinetic law: MODEL1310110035#

metaM thyox L c
initial amount: NaN
has only substance units: false
is: HMDB00248
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
boundary condition: false

metaR S6T14g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_7309ebe6_5654_4a1a_bb05_a7d41c5d0a23
is: Q8WY07
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84889
initial amount: NaN
constant: false
boundary condition: true
name: SLC7A3
type: Species

metaR IDOURte
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
name: L-iduronate transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM clpndcoa x
is: SBO:0000247
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
is: C16166
constant: false
is: HMDB06267
name: clupanodonyl CoA
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205476
initial amount: NaN

metaR RE1691M
reactant: MODEL1310110035#
name: RE1691
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.8.1.1
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reversible: true

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_97f099e9_ab1f_4ee8_9cf5_f10c1a1d3330
initial concentration: NaN
name: NDUFB6
boundary condition: true
is: O95139
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:4712
initial amount: NaN
type: Species

metaM 3octdectecoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM idp n
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58280
is: HMDB03335
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: SBO:0000247

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is: SBO:0000176
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true

metaM gm3 hs g
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:60065

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205481
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: C16171
is: HMDB06516
boundary condition: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_6e637a11_3eb9_4dc2_98a1_dbbfbd4147fc
name: GOT2
type: Species
has only substance units: false
is: P00505
is encoded by: hsa:2806
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r2373
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110035#_26f1997f_08fb_4d57_9752_f1e3753cb0fa
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: ALAD
is encoded by: hsa:210
is: P13716
initial amount: NaN
boundary condition: true

metaR THRCYSNaEx
reversible: false
reactant: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
is described by: ECO:0000269
type: Reaction
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110035#_51eab768_3553_4b16_b76c_8efeec83fc43
initial concentration: NaN
name: ALPI
type: Species
boundary condition: true
is: P09923
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:248

metaM 11 cis retfa e
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00972
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false
initial concentration: 1.0
name: fatty acid 11-cis-retinol
is: CHEBI:57454
boundary condition: false

metaR r0130
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
modifier: MODEL1310110035#
reversible: true
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false

metaM ptth e
initial amount: NaN
has only substance units: false
is: HMDB03426
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
name: pantetheine
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16753

http://identifiers.org/biomodels.db/MODEL1310110035#_0c67cf76_5b62_4e25_82fc_d94eeacc44a3
constant: false
has part: Q969N2
is encoded by: hsa:10026
has part: Q92643
is encoded by: hsa:8733
initial amount: NaN
is encoded by: hsa:51604
initial concentration: NaN
has only substance units: false
boundary condition: true
has part: Q8NBL9
is: SBO:0000297
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: Q9H490
is encoded by: hsa:94005
is encoded by: hsa:128869
has part: O43292
type: Species

metaM nadph x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: HMDB00221
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: C00005
is: SBO:0000247
boundary condition: false
constant: false

metaR DOLPMT L
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.83
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
fast: false
name: Dolichyl-phosphate D-mannosyltransferase (liver)
is described by: ECO:0000000
is: SBO:0000176

metaR CHOLESTle
name: hydrolysis of cholesterol ester by cholesterol esterase
fast: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.13
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR CSPG Etly
reversible: false
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
fast: false
is: SBO:0000185
type: Reaction
name: chondroitin sulfate E transport, extracellular to lysosome
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM c4crn e
name: butyryl carnitine
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
is: HMDB02013
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_15f58f20_a0c8_4a4b_9817_66bb7df70503
is: SBO:0000252
name: GBA
type: Species
is encoded by: hsa:2629
boundary condition: true
has only substance units: false
is: B7Z6S9
initial concentration: NaN
constant: false
initial amount: NaN

metaM gdp c
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58189
boundary condition: false
is: SBO:0000247
is: C00035
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
is: HMDB01201
initial concentration: 1.0

metaR r1616
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TREHe
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110035#
product: MODEL1310110035#
name: alpha,alpha-trehalase
reactant: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR

metaR C4STMO1r
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
modifier: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f0f145f3_3ef3_4d1d_bd0d_e24249eb82bb
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: BCKDHA
has only substance units: false
constant: false
is: B4DP47
is encoded by: hsa:593

http://identifiers.org/biomodels.db/MODEL1310110035#_92776130_def1_471a_acd1_ff8ecb4cac1b
type: Species
name: AGXT2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:64902
is: Q9BYV1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_5e92368d_d860_4da3_bb55_963ec34ef272
is encoded by: hsa:1329
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q53YB7
name: COX5B

http://identifiers.org/biomodels.db/MODEL1310110035#_89942c3e_19e5_4c6b_b15b_a8235c8645e5
is: Q9Y673
boundary condition: true
name: ALG5
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:29880

metaR RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
type: Reaction
name: RE1233
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
modifier: MODEL1310110035#

metaM retfa c
is: SBO:0000247
is: CHEBI:50211
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
boundary condition: false
is: HMDB00305
name: fatty acid retinol

metaM 4nph c
constant: false
is: SBO:0000247
is: CHEBI:57917
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
name: 4-nitrophenolate
boundary condition: false
initial concentration: 1.0

metaR HIBDm
modifier: MODEL1310110035#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM

metaR ECOAH1m
modifier: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110035#
is described by: ECO:0000304
fast: false
product: MODEL1310110035#

metaR r1617
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_0f50625c_6299_4032_b17b_aeca6fca1991
has only substance units: false
is encoded by: hsa:85365
is: SBO:0000252
constant: false
type: Species
name: ALG2
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR HSAT1ly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000

metaM arachcoa c
initial amount: NaN
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false
constant: false
name: arachidyl coenzyme A
initial concentration: 1.0
type: Species
is: HMDB04258
is: CHEBI:15527
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_83abe687_59a4_4ce4_a3d5_a629cb08e52a
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
is: SBO:0000252

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110035#
product: MODEL1310110035#

metaM ptth c
is: HMDB03426
is: CHEBI:16753
constant: false
initial concentration: 1.0
name: pantetheine
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM eitetcoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
constant: false
is: SBO:0000247
type: Species

metaM pmtcoa c
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:3454
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: C00154
is: SBO:0000247

metaR OCD11CRNCPT2
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR MACACI
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110035#
fast: false
name: maleylacetoacetate isomerase
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
reversible: false
product: MODEL1310110035#
is: SBO:0000176

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR FAOXC163Gm
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
is: CHEBI:16066
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02152
is: SBO:0000247
name: 11-cis-retinal
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_30cd5527_1e67_40a3_b901_ca2cb9b4c8bf
is encoded by: hsa:11212
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: PROSC
has only substance units: false
is: O94903
initial concentration: NaN

metaR ACETONEt2
reversible: true
modifier: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110035#
name: acetone transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

metaM HC01231 c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:58480
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaR ALAtN1
is: SBO:0000185
modifier: MODEL1310110035#
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110035#
reversible: true
type: Reaction

metaR MANt4
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-mannose transport via sodium cotransport
product: MODEL1310110035#
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000185

metaR r1614
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_dc14f3a9_5624_4ccb_8398_30458a038d76
is encoded by: hsa:4669
initial concentration: NaN
is: SBO:0000252
is: P54802
has only substance units: false
constant: false
name: NAGLU
type: Species
boundary condition: true
initial amount: NaN

metaR UDPACGALtl
type: Reaction
reactant: MODEL1310110035#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110035#
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f2b2333c_95fc_49d6_b0e7_4df1d30670ce
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC34A1
is: SBO:0000252
constant: false
is: Q7Z725
initial amount: NaN
is encoded by: hsa:6569
type: Species

metaR BTNPL
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is version of: http://identifiers.org/ec-code/6.3.4.10
name: holocarboxylase synthestase (biotin protein ligase)
is described by: ECO:0000000
modifier: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
type: Reaction
fast: false
product: MODEL1310110035#

metaM retfa e
name: fatty acid retinol
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15963
has only substance units: false
is: HMDB00508
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false

metaM acmanap c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
constant: false
initial concentration: 1.0
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: CHEBI:58557
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01121

metaM ksii core2 deg4 l
boundary condition: false
is: CHEBI:16953
type: Species
is: SBO:0000247
notes: FORMULA: C58H95N5O43SX CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00812
name: keratan sulfate II (core 2-linked), degradation product 4

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r1615
kinetic law: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 4nph e
is: SBO:0000247
is: CHEBI:57917
initial amount: NaN
type: Species
is: HMDB01232
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
constant: false
boundary condition: false
initial concentration: 1.0

metaM sphings c
name: sphingosine(1+)
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB00252
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57756

metaR B3GNT11g
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
reversible: false
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000269

metaM lnlc c
boundary condition: false
type: Species
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
initial concentration: 1.0
is: HMDB00673
name: linoleate
has only substance units: false
initial amount: NaN
is: CHEBI:30245

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.1.12
is described by: ECO:0000134
product: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_276c4de3_a4ef_423e_9534_2b1a5e2a825f
constant: false
is: P28329
type: Species
boundary condition: true
initial concentration: NaN
name: CHAT
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110035#_befd2e8a_7c11_4ba5_b825_d366011c2c1c
constant: false
is: P08397
name: HMBS
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3145

metaM 4h2oglt m
has only substance units: false
is: HMDB02070
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: 4-hydroxy-2-oxoglutarate(2-)
is: CHEBI:17742

metaR PSYGCHe
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR r1612
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM 9 cis retfa e
is: HMDB06559
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
boundary condition: false
name: fatty acid 9-cis-retinol

http://identifiers.org/biomodels.db/MODEL1310110035#_ad37b920_7a04_449a_b582_f2ceee0de4e8
has only substance units: false
is encoded by: hsa:50
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: ACO2
constant: false
initial concentration: NaN
is: Q99798

metaM arachcoa e
initial concentration: 1.0
is: SBO:0000247
is: HMDB04258
has only substance units: false
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species
name: arachidyl coenzyme A
is: CHEBI:15527
boundary condition: false
initial amount: NaN

metaM dgchol c
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:36252
type: Species
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
boundary condition: false

metaM dag hs n
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
type: Species
initial concentration: 1.0
name: diglyceride
is: CHEBI:18035

metaR SCP21cx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_9df91426_94d9_4d8a_af7e_37146c9ac759
name: DUOX2
is: Q9NRD8
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:50506

http://identifiers.org/biomodels.db/MODEL1310110035#_d69b7906_ef46_4405_b00c_ff4eb7b24e42
is encoded by: hsa:6536
type: Species
boundary condition: true
is: B7Z3W8
has only substance units: false
constant: false
initial concentration: NaN
name: SLC6A9
is: SBO:0000252
initial amount: NaN

metaR r0559
reversible: true
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110035#

metaM gal e
initial amount: NaN
is: C00124
name: D-Galactose
boundary condition: false
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
is: HMDB00143
has only substance units: false
is: SBO:0000247

metaM 3aib D m
is: C03265
boundary condition: false
name: D-3-Amino-isobutanoate
has only substance units: false
type: Species
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR MECOALm
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110035#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false

metaM Nacasp c
is: SBO:0000247
name: N-acetyl-L-aspartate(2-)
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
is: HMDB00812
is: CHEBI:16953
initial amount: NaN
boundary condition: false

metaR FAOXC61C4m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_624861f4_d867_4935_a28f_a94e5ce82b38
name: AMY1C
has only substance units: false
is: P04745
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:278
constant: false
initial concentration: NaN

metaR r1613
modifier: MODEL1310110035#
type: Reaction
fast: false
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_4cf47d52_dca4_42db_a388_9b71a777a51a
initial amount: NaN
is: O14939
constant: false
name: PLD2
is encoded by: hsa:5338
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR MMSAD1m
type: Reaction
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
fast: false
reversible: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
name: methylmalonate-semialdehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_faaf07f5_6025_4921_b9af_3de55b3fb518
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: MYO5B
is encoded by: hsa:4645
is: Q9H6Y6

http://identifiers.org/biomodels.db/MODEL1310110035#_1c70cb5d_971b_4c21_82e6_8cc5f3b53122
is: SBO:0000252
is encoded by: hsa:54995
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9NWU1
name: OXSM
constant: false

metaM lnlc e
type: Species
is: HMDB00673
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
constant: false
is: CHEBI:30245
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: linoleate

metaM cytd m
boundary condition: false
has only substance units: false
name: cytidine
initial amount: NaN
type: Species
constant: false
is: HMDB00089
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR S2TASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
type: Reaction
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05875
constant: false
is: SBO:0000247
type: Species

metaM uri m
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00296
constant: false
is: SBO:0000247
name: uridine

http://identifiers.org/biomodels.db/MODEL1310110035#_c49dd69e_e854_4b8c_be7d_3710bad87e18
name: ASRGL1
is: Q7L266
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:80150
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r0558
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29

metaM L2aadp6sa c
is: CHEBI:17917
constant: false
type: Species
name: L-allysine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

http://identifiers.org/biomodels.db/MODEL1310110035#_8ad23572_809f_475f_a594_18338e6d360a
constant: false
initial amount: NaN
has only substance units: false
name: SLC4A3
boundary condition: true
is: P48751
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6508

metaR r1610
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110035#
fast: false

metaR AKR1D
type: Reaction
fast: false
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110035#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269

metaM g3m8masn r
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
boundary condition: false
is: C05873
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN

metaM c4crn c
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
constant: false
initial concentration: 1.0
has only substance units: false
name: butyryl carnitine
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
is: SBO:0000247
type: Species
is: HMDB02013

http://identifiers.org/biomodels.db/MODEL1310110035#_066f3bf2_3937_4cf0_aace_e3df15486d7e
type: Species
is encoded by: hsa:27068
boundary condition: true
initial amount: NaN
is: F8WDN9
name: PPA2
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM dgchol e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36252
constant: false
name: glycochenodeoxycholate
boundary condition: false
is: SBO:0000247
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
type: Species

metaM g3m8mpdol L r
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01342
is: CHEBI:37568
constant: false
is: SBO:0000247
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: C00459
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false

metaR RE3003M
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
name: RE3003
reversible: true
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_d43cff38_7322_498e_a3bd_eba2488814de
constant: false
name: _100128062_1_m
initial amount: NaN
is encoded by: hsa:100128062
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_60a75a32_3621_4077_a49f_9dffa4595545
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10965
is: P49753
constant: false
initial concentration: NaN
name: ACOT2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_5b8adf18_4144_4d2d_9e27_138641a6db3b
boundary condition: true
type: Species
name: B3GNT2
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10678
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_b6215be2_701e_44c7_9edc_91a34ff22aa5
type: Species
name: HSD17B10
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q99714
is encoded by: hsa:3028

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR CRVNCtr
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#

metaM 56dura c
name: 5,6-dihydrouracil
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
has only substance units: false
is: HMDB00076
boundary condition: false
is: CHEBI:15901
is: SBO:0000247
initial concentration: 1.0

metaR r1611
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_ec575cda_8284_46ec_a00d_6390167a236a
boundary condition: true
is encoded by: hsa:7001
name: PRDX2
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM dcamp c
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00536
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
is: C03794

metaR FAOXC183806x
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
is described by: ECO:0000269
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110035#_bf2ce4cf_0b3a_4602_9c42_c77dcac01945
has only substance units: false
name: LEFTY1
is encoded by: hsa:10637
is: SBO:0000252
is: O75610
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR FAOXC102m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_706b5184_6ffa_447d_9712_8c1ff4ad319b
has only substance units: false
initial amount: NaN
name: PHYH
is: SBO:0000252
boundary condition: true
is: O14832
type: Species
initial concentration: NaN
is encoded by: hsa:5264
constant: false

metaM HC01231 m
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
has only substance units: false
is: CHEBI:58480
constant: false
initial concentration: 1.0

metaR NACASPtm
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_c4c312d8_be87_4ed9_9fc5_dac5eb2a627c
constant: false
is encoded by: hsa:57134
type: Species
is: Q9NR34
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: MAN1C1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_c5bfb8a6_cbf3_4d2b_a45c_4bf77d7030b4
boundary condition: true
is encoded by: hsa:4723
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFV1
initial concentration: NaN
is: E5KNH5

http://identifiers.org/biomodels.db/MODEL1310110035#_1a298476_5b14_4a7f_b81a_8642f33f505c
name: NDUFV2
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4729
is: SBO:0000252
is: P19404

metaR r0556
reversible: true
reactant: MODEL1310110035#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
type: Reaction
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_4485c500_563b_4870_89d9_278487303b7a
type: Species
boundary condition: true
has only substance units: false
constant: false
name: FASN
is: P49327
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2194

metaM cs e deg5 l
is: SBO:0000247
is: CHEBI:57737
is: HMDB00868
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial amount: NaN
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
type: Species

metaM udpglcur r
boundary condition: false
constant: false
is: C00167
has only substance units: false
is: CHEBI:58052
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00935
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM cysam c
name: cysteaminium
constant: false
initial amount: NaN
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:58029
is: SBO:0000247
type: Species
is: HMDB02991

metaR RPEc
reversible: true
name: ribulose 5-phosphate 3-epimerase
fast: false
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2

metaR r0242
is: SBO:0000176
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110035#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is described by: ECO:0000000
fast: false

metaM HC10852 r
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: palmitoleyl-CoA(4-)
is: SBO:0000247
has only substance units: false
is: CHEBI:61540
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial amount: NaN

metaM dag hs c
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18035
name: diglyceride
type: Species

metaR r0836
kinetic law: MODEL1310110035#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110035#_dc786e31_f420_41bf_a2fd_bb25a29e4df0
boundary condition: true
initial amount: NaN
name: SLC25A26
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:115286
is: F8WAB8
has only substance units: false

metaM cspg b l
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
boundary condition: false
constant: false
is: CHEBI:36005
is: HMDB02183
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan

metaR FAOXC13C11m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_65dfddd1_5499_4e71_97ef_0ce1478d81e5
initial amount: NaN
is: Q14032
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: BAAT
type: Species
constant: false
is encoded by: hsa:570

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110035#
fast: false
is: SBO:0000176

metaR r0839
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
name: Postulated transport reaction
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_72503a0f_8fa9_4151_9429_5395f51a889d
constant: false
name: UMPS
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: A8K5J1
type: Species
initial amount: NaN
is encoded by: hsa:7372

metaM stcoa c
has only substance units: false
constant: false
is: CHEBI:57394
is: C00412
initial amount: NaN
is: HMDB01114
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_c422c486_01e6_4802_be84_26a3db243e3c
boundary condition: true
is: Q01581
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3157
type: Species
initial amount: NaN
name: HMGCS1

http://identifiers.org/biomodels.db/MODEL1310110035#_4b31460d_0432_40bd_a8f2_c474521047f8
initial amount: NaN
name: GALNT6
has only substance units: false
is encoded by: hsa:11226
boundary condition: true
constant: false
is: Q8NCL4
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_8a6e172d_2772_431b_b0b5_7024d6c24f9f
has only substance units: false
is: P38571
initial amount: NaN
is encoded by: hsa:3988
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: LIPA
type: Species

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_2f528d19_e2c3_4ef6_bea4_3aa7edf43f8b
initial concentration: NaN
is: P36021
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC16A2
is encoded by: hsa:6567
has only substance units: false
constant: false

metaM cytd c
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17562
is: HMDB00089
name: Cytidine
constant: false
initial concentration: 1.0
initial amount: NaN

metaM tetpent6coa c
constant: false
has only substance units: false
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false
is: C16172
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
type: Species

metaM nadph m
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00221
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaM gal c
has only substance units: false
name: D-Galactose
initial concentration: 1.0
is: CHEBI:0
constant: false
is: HMDB00143
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
is: C00124
is: SBO:0000247

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR r0838
reversible: true
is: SBO:0000185
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_8ee5842f_56d6_4ace_9602_e8ebda7167e1
has only substance units: false
is encoded by: hsa:3418
type: Species
initial concentration: NaN
is: P48735
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: IDH2

metaR r2079
reactant: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM Nacasp m
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
has only substance units: false
is: HMDB00812
name: N-acetyl-L-aspartate(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16953

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58189
constant: false
boundary condition: false
name: GDP(3-)
is: HMDB01201
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7aa3a7ae_b485_499e_ab4a_aba133c5a817
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: ATP5F1
initial amount: NaN
is encoded by: hsa:515
initial concentration: NaN

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110035#
reversible: true
fast: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

http://identifiers.org/biomodels.db/MODEL1310110035#_44b76075_6d28_47f7_a9f0_dbc621f1fbec
constant: false
initial concentration: NaN
name: ST3GAL5
is: Q9UNP4
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8869
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_edcf9363_73b1_497e_8f23_a10982bb7d4d
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9UN42
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:23439
name: ATP1B4

metaR DESAT18 4
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110035#
is described by: ECO:0000000
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_4d225a02_ba4b_479e_9b17_3d5c99d55f05
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: F5H2Y9
name: ALDH1A2
constant: false
is encoded by: hsa:8854

metaR MM5cg
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110035#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110035#
fast: false

metaM odecoa c
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:3793
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB01322

metaR DUTPDPn
modifier: MODEL1310110035#
fast: false
is described by: ECO:0000269
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110035#
is: SBO:0000176
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110035#

metaR S6T9g
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110035#
fast: false
reversible: false
type: Reaction

metaM uri c
name: Uridine
is: CHEBI:16704
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: C00299
initial concentration: 1.0
type: Species
is: HMDB00296
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaM hepcoa m
boundary condition: false
has only substance units: false
is: HMDB12969
initial amount: NaN
initial concentration: 1.0
type: Species
name: heptanoylcoa
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c390b531_ae52_4b0f_b6c9_2ef040e65027
has only substance units: false
is encoded by: hsa:AI345944
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: _AI345944_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_3c920d01_d116_4ff3_9f34_a1dbf9759295
is encoded by: hsa:6240
is: P23921
boundary condition: true
type: Species
initial concentration: NaN
name: RRM1
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR NDP7er
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
type: Reaction
fast: false

metaM cytd e
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
is: CHEBI:17562
is: HMDB00089
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: Cytidine
type: Species

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_465f059f_b9ba_48cc_b7bb_a25551986f67
initial amount: NaN
is: SBO:0000252
type: Species
name: TST
has only substance units: false
boundary condition: true
is: Q16762
constant: false
is encoded by: hsa:7263
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_4a36898b_6c72_4ca8_a378_7ff36faa7b68
initial amount: NaN
type: Species
name: SLC6A5
is: Q9Y345
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9152

metaR UGLCNACtg
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
name: UDP-GlcNAc Golgi transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110035#_7d7545ef_89af_4a7e_baf6_3550287f8020
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PPA2
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: Q9H2U2
is encoded by: hsa:27068

metaM gdp e
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58189
boundary condition: false
name: GDP(3-)
has only substance units: false
constant: false

metaM 3aib D c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
is: C03265
name: D-3-Amino-isobutanoate
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB02299
type: Species
is: SBO:0000247

metaR NACHEX15ly
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
type: Reaction
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0e2a4713_53a4_4038_87d4_9db358227b9b
name: _AA977580_1_c
type: Species
constant: false
is encoded by: hsa:AA977580
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DESAT18 6
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
is: SBO:0000176
reversible: false

metaM ksi deg1 l
name: keratan sulfate I, degradation product 1
constant: false
initial concentration: 1.0
is: CHEBI:18287
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species
initial amount: NaN
is: HMDB00174
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM biliverd c
is: CHEBI:57991
initial amount: NaN
boundary condition: false
has only substance units: false
name: biliverdin(2-)
is: HMDB01008
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3bb12e48_bcea_402c_ada8_ee324d9c5d59
initial amount: NaN
is encoded by: hsa:2643
is: SBO:0000252
boundary condition: true
is: Q8IZH9
constant: false
initial concentration: NaN
type: Species
name: GCH1
has only substance units: false

metaR r0835
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
is: SBO:0000185

metaM uri e
is: CHEBI:16704
name: Uridine
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7ff36190_90e4_4b30_9eff_e5f0beb3246d
is encoded by: hsa:6241
initial concentration: NaN
name: RRM2
boundary condition: true
type: Species
is: P31350
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR FAOXC2452253x
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:- in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) confusing name, sorry - accounting for omega3 vs omega6 FA peroxisomal (very long chain FA) c24:5,n-3 -> c22:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaM nadph r
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57783
is: C00005
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
has only substance units: false

metaR KSIt
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular
fast: false
is described by: ECO:0000000

metaR RE3626M
is: SBO:0000176
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
name: RE3626
reversible: false
type: Reaction

metaR ASNSERNaEx
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110035#
product: MODEL1310110035#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
modifier: MODEL1310110035#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c9dcf447_2af5_4be0_88fe_5ac1e7170334
is encoded by: hsa:1716
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: DGUOK
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d94e1ec2_09bc_45a7_9a9d_acc160818bf2
is: Q59HH3
has only substance units: false
initial amount: NaN
is encoded by: hsa:2618
initial concentration: NaN
name: GART
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM eitetcoa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: 5,8,11,14-eicosatetraenoylcoa
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM glx c
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
initial amount: NaN
is: SBO:0000247
is: CHEBI:36655
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species

metaR S6TASE24ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110035#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM hexe3coa m
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 3-hexenoylcoa
constant: false
boundary condition: false
is: HMDB06522

metaM dag hs e
initial amount: NaN
is: CHEBI:18035
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
name: diglyceride
initial concentration: 1.0

metaR DESAT18 5
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is described by: ECO:0000269
reactant: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_96a98bf7_0ef3_4d4c_b2e4_d82e0c58f751
name: SULT2B1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6820

metaM hs deg24 l
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
notes: FORMULA: C31H50NO26 CHARGE: -1
has only substance units: false
is: CHEBI:16126
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaM CE5114 x
is: CHEBI:57923
name: trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,20-21,28-30,34-36,40,51-52H,4-7,10,13,16-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5114
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM icit c
is: CHEBI:16087
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
is: C00311
type: Species
is: SBO:0000247
name: Isocitrate

metaR PRDX
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
is version of: http://identifiers.org/ec-code/1.11.1.7
reactant: MODEL1310110035#
reversible: false
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
name: Peroxidase (multiple substrates)

metaM cala c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial amount: NaN
is: CHEBI:11892
constant: false
is: HMDB00026
name: N-carbamoyl-beta-alaninate

http://identifiers.org/biomodels.db/MODEL1310110035#_45cddd12_cf38_4100_b705_3fbecb8166a3
is: SBO:0000252
is encoded by: hsa:AA278423
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AA278423_1_c

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM taur e
is: HMDB00251
boundary condition: false
is: C00245
initial concentration: 1.0
constant: false
is: CHEBI:3544
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine
initial amount: NaN

metaM fmn c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58210
is: C00061
initial concentration: 1.0
is: HMDB01520
boundary condition: false
name: FMN
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061

metaM cbasp e
initial amount: NaN
is: HMDB00828
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: C00438
type: Species
is: CHEBI:32814
name: N-Carbamoyl-L-aspartate
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_73693a79_a90a_44fa_b13f_61d3ddb487ca
initial amount: NaN
has part: P56134
boundary condition: true
type: Species
is encoded by: hsa:522
is encoded by: hsa:9551
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has only substance units: false
constant: false

metaR CBR2
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.189
fast: false
is: SBO:0000176
name: Carbonyl reductase [NADPH] 1
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaM nad n
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57540
boundary condition: false
name: NAD(1-)
initial concentration: 1.0
is: HMDB00902
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_289a1879_79ae_4611_b46e_ecbf12dd07a5
name: HSD17B2
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3294
boundary condition: true
has only substance units: false
is: P37059

metaR NRPPHRt4 2 r
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110035#_73666e07_0461_4cc9_8fb6_56baef65ba95
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:518

metaR RE1447N
type: Reaction
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
name: RE1447
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM spmd e
is: HMDB01257
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0
boundary condition: false
is: C00315
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57834
type: Species
name: Spermidine

metaR FAOXC1811603m
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110035#
fast: false
reversible: false
name: Beta oxidation fatty acid

metaR RE2677E
name: RE2677
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reversible: false
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#

metaM nad m
is: SBO:0000247
is: HMDB00902
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
has only substance units: false
constant: false
is: C00003
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_9916791b_4d4a_4de0_bffc_a7cf4cbdfa02
has only substance units: false
type: Species
is: Q13907
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3422
constant: false
is: SBO:0000252
boundary condition: true
name: IDI1

http://identifiers.org/biomodels.db/MODEL1310110035#_91abdfa9_8244_48b1_8c5e_316ab9ede310
is: SBO:0000252
name: B3GNT5
boundary condition: true
initial concentration: NaN
is: Q9BYG0
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:84002
has only substance units: false

metaM lgnccoa x
constant: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
type: Species
is: HMDB06526
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: lignocericyl coenzyme A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_33a8a4e8_a508_4130_8cae_e57308a6d667
name: MSMO1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6307
has only substance units: false
constant: false
is: A8MYF6

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_777cda9f_700b_4b4a_9274_870bfed70ec4
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9P019
type: Species
boundary condition: true
is encoded by: hsa:29085
has only substance units: false
name: PHPT1

metaR XOLTRI24tc
kinetic law: MODEL1310110035#
name: 24 trihydroxy cholesterol transport
reactant: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_bf5da791_a8b4_460a_9465_fc96b78758bd
constant: false
is encoded by: hsa:1719
is: SBO:0000252
initial amount: NaN
name: DHFR
type: Species
initial concentration: NaN
is: P00374
boundary condition: true
has only substance units: false

metaR r0994
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: Facilitated diffusion

metaR RETFA
name: retinol acyltransferase
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000

metaM Rtotal3 c
initial concentration: 1.0
constant: false
is: CHEBI:16189
initial amount: NaN
boundary condition: false
name: R total 3 position
is: HMDB01448
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: SBO:0000247
type: Species

metaR GALASE13ly
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110035#_7e3da450_8a01_4a27_aa62_e0ed69cd9efe
is encoded by: hsa:9487
boundary condition: true
name: PIGL
constant: false
is: Q9Y2B2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0995
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#

metaR LNELDCt
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR NDP7ex
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: nucleoside-diphosphatase (UDP), extracellular
modifier: MODEL1310110035#
reversible: false

metaM e4p c
name: D-Erythrose 4-phosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16897
is: C00279
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01321

metaR FACOAL1812
modifier: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110035#

metaM taur c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00251
initial concentration: 1.0
has only substance units: false
is: C00245
is: CHEBI:3544
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
name: Taurine

metaR CERT2gt
reversible: true
is: SBO:0000185
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
name: ceramide transport protein
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR EX c4crn
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r0830
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110035#_d861d21f_ae57_440d_b031_d6655920769d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: P30519
is encoded by: hsa:3163
initial amount: NaN
name: HMOX2

metaM cbasp c
is: C00438
initial concentration: 1.0
type: Species
name: N-Carbamoyl-L-aspartate
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
constant: false
is: HMDB00828
is: SBO:0000247
is: CHEBI:32814

metaR FAS160COA
is: SBO:0000176
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reactant: MODEL1310110035#

metaR FACOAL1813
is described by: ECO:0000269
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
modifier: MODEL1310110035#
is: SBO:0000176
type: Reaction
name: fatty-acid--CoA ligase

metaR PI45P3K
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110035#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false

metaR DMNONCOACRNCPT1
kinetic law: MODEL1310110035#
name: DMNONCOACRNCPT1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM prostgh2 e
boundary condition: false
is: HMDB01381
constant: false
name: prostaglandin H2(1-)
initial amount: NaN
is: CHEBI:57405
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species

metaM lnlc r
boundary condition: false
has only substance units: false
name: linoleate
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673

http://identifiers.org/biomodels.db/MODEL1310110035#_ff6c2d2c_1fbf_481f_b3e9_30919adfb167
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1103
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: CHAT
is: Q6LEN6

http://identifiers.org/biomodels.db/MODEL1310110035#_0012ba93_2e3c_4d8b_ad30_f32e90c3234f
is encoded by: hsa:51102
constant: false
is: Q9BV79
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: MECR

metaM Rtotal3 e
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00255
is: CHEBI:3554
boundary condition: false
name: R total 3 position
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1
has only substance units: false
type: Species
is: HMDB00244

metaM fmn e
is: HMDB01520
initial amount: NaN
is: C00061
name: FMN
type: Species
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58210
boundary condition: false

metaR G14T15g
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110035#
fast: false
type: Reaction
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_175e4f01_83da_4917_bbb4_a38e14f5e0ff
initial concentration: NaN
is: O76074
has only substance units: false
constant: false
is encoded by: hsa:8654
boundary condition: true
is: SBO:0000252
type: Species
name: PDE5A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ce4be6d9_7c6f_4f76_9d94_e034a8ee9b59
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CBR1
initial concentration: NaN
type: Species
is: P16152
is encoded by: hsa:873
constant: false
boundary condition: true

metaM gdp n
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
type: Species
is: HMDB01201
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_60bac947_e31a_42df_b5a0_22cfc5654536
is: Q2TU34
is encoded by: hsa:2203
type: Species
boundary condition: true
has only substance units: false
name: FBP1
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_35dedfb2_29bc_485a_ab0e_b935278e9afd
has only substance units: false
name: PDE1A
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5136
is: P54750
is: SBO:0000252
constant: false

metaR r0997
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110035#
name: COT Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000

metaR C226COAtx
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110035#
is described by: ECO:0000000
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110035#_55baeb68_c43e_4796_9232_e044faa628d7
is encoded by: hsa:NOS2A
type: Species
name: _NOS2A_1_e
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR ATP1ter
fast: false
product: MODEL1310110035#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
name: ADP/ATP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM galgluside hs l
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
boundary condition: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110035#_c317e90d_c761_4f13_8b57_2628abdf3312
initial amount: NaN
name: GALK2
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q01415
is encoded by: hsa:2585

http://identifiers.org/biomodels.db/MODEL1310110035#_835b0170_5a93_453e_8f37_193a8c01b086
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6799
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P50226
name: SULT1A2

metaM gchola x
is: CHEBI:58235
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
name: glycocholate
is: SBO:0000247
is: HMDB00138
initial amount: NaN
boundary condition: false

metaR MI14Ptn
kinetic law: MODEL1310110035#
fast: false
reversible: true
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
is: SBO:0000185
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaM prostgh2 c
type: Species
name: prostaglandin H2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
is: HMDB01381
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57405

metaR D3AIBTm
kinetic law: MODEL1310110035#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000

metaR r0998
name: Facilitated diffusion
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110035#

metaM 6pgc r
initial amount: NaN
name: 6-phosphonatooxy-D-gluconate
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58759
type: Species
is: HMDB01316
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_b14074d4_c62f_42d0_88ee_279488776bfa
initial concentration: NaN
boundary condition: true
type: Species
name: AK1
is encoded by: hsa:203
is: P00568
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_73cc82a0_c5eb_417e_92d1_90f673275825
constant: false
initial amount: NaN
name: ACSL4
has only substance units: false
boundary condition: true
is: Q5JWV8
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2182

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR S23T4g
fast: false
is described by: ECO:0000000
modifier: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
reversible: false
name: beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction

metaR MECOAS1m
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176
product: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304
modifier: MODEL1310110035#
fast: false
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR PSFLIPm
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
reversible: false
type: Reaction
name: phosphatidylserine flippase
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.3.1
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaR CSBPASEly
reversible: false
is: SBO:0000176
fast: false
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000

metaR RE1804M
name: RE1804
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_22577517_824d_4add_aedd_36fb645fcc7d
boundary condition: true
name: MTMR1
is: SBO:0000252
is encoded by: hsa:8776
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: Q13613

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_3339b5ed_02c8_422a_87b7_4b8749b04bdc
initial concentration: NaN
initial amount: NaN
constant: false
name: _728226_1_e
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:728226
type: Species

metaR PYRt2r
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: pyruvate reversible transport via proton symport
kinetic law: MODEL1310110035#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110035#_dd575037_63d0_4cc7_a151_5a90935413ab
is encoded by: hsa:26330
is: SBO:0000252
type: Species
boundary condition: true
is: O14556
initial amount: NaN
has only substance units: false
constant: false
name: GAPDHS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_06355575_5d10_4d5e_9a73_821f6d567ef4
boundary condition: true
name: NANS
constant: false
is: SBO:0000252
is: Q9NR45
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:54187

http://identifiers.org/biomodels.db/MODEL1310110035#_608b145b_b386_42c3_a2b6_1c8636c3aa8a
constant: false
name: _AI435857_1_x
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI435857
type: Species

metaR DAGKn hs
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
is described by: ECO:0000269
product: MODEL1310110035#
name: Diacylglycerol phosphate kinase (homo sapiens)
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000176
kinetic law: MODEL1310110035#

metaR DM ethamp r
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR CHLtm
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
type: Reaction
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
product: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reversible: true

metaR r0999
name: Facilitated diffusion
product: MODEL1310110035#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_da03eeae_8e9e_4279_bdbf_f22402692611
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10587
constant: false
name: TXNRD2
is: Q9NNW7
initial amount: NaN
boundary condition: true

metaR B3GNT314g
modifier: MODEL1310110035#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
is described by: ECO:0000254

metaR r0236
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
product: MODEL1310110035#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1

metaR FAOXC185C164m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_054dab38_b22e_4c5d_b1c1_d0998c5b4f2b
has only substance units: false
initial amount: NaN
is encoded by: hsa:5294
constant: false
name: PIK3CG
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P48736

metaR FUMSO4tm
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: Fumarate:sulfate antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110035#_d305ad52_61d7_466f_a68e_a0efe19223e9
has only substance units: false
is: P28331
type: Species
initial concentration: NaN
is encoded by: hsa:4719
name: NDUFS1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM arachcoa x
is: CHEBI:15527
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
boundary condition: false
is: HMDB04258
is: SBO:0000247

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: UMP kinase (CTP),nuclear
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
reversible: true

metaM spmd c
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
constant: false
initial amount: NaN
is: CHEBI:57834
boundary condition: false
type: Species
has only substance units: false
is: HMDB01257
is: C00315
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_097948fc_0921_4439_9a88_628253bc7e76
constant: false
is encoded by: hsa:5471
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q06203
name: PPAT

metaR PNTEH
is described by: ECO:0000269
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
fast: false
product: MODEL1310110035#
name: Hydrolase Class ( RXN R02973)
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
is: SBO:0000176

metaR BHBt
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110035#
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV

metaR ALAGLYexR
modifier: MODEL1310110035#
is: SBO:0000185
reversible: true
product: MODEL1310110035#
type: Reaction
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000304
reactant: MODEL1310110035#

metaM gdp m
initial concentration: 1.0
type: Species
is: C00035
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
is: CHEBI:58189
name: GDP
boundary condition: false
is: HMDB01201

http://identifiers.org/biomodels.db/MODEL1310110035#_08428ab1_5806_477c_854d_6756d95bca2e
is: Q9NRD9
is: SBO:0000252
has only substance units: false
name: DUOX1
constant: false
boundary condition: true
is encoded by: hsa:53905
initial concentration: NaN
initial amount: NaN
type: Species

metaR GALASE10ly
reversible: false
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110035#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110035#

metaR IDOAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
name: alpha-L-iduronidase, lysosomal

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_c7aa5dfc_852f_44a9_9221_d5dcde586621
type: Species
is encoded by: hsa:19
has only substance units: false
is: SBO:0000252
constant: false
is: O95477
initial concentration: NaN
boundary condition: true
name: ABCA1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_90a22cc8_a3c9_46a4_8fa4_c76b26d006e5
constant: false
is: P37837
boundary condition: true
is: SBO:0000252
name: TALDO1
type: Species
initial concentration: NaN
is encoded by: hsa:6888
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ebacd3a7_97a1_47f3_beb5_0353d9cae43d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2182
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: ACSL4
is: O60488

http://identifiers.org/biomodels.db/MODEL1310110035#_272364b0_e256_445f_b32a_5a42db06e079
is: SBO:0000252
is encoded by: hsa:9963
is: Q9UHI7
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC23A1

metaM gsn c
name: Guanosine
boundary condition: false
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:16750
has only substance units: false
is: C00387
is: HMDB00133

http://identifiers.org/biomodels.db/MODEL1310110035#_d5f5b902_36ae_46ad_8f46_2ba86caced2c
is: Q9NRA0
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56848
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: SPHK2

metaR XOLTRI24te
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: 24 trihydroxy cholesterol transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110035#

metaR DHPR2
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
kinetic law: MODEL1310110035#
is described by: ECO:0000304
reversible: false
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is: SBO:0000176
name: 6,7-dihydropteridine reduction
type: Reaction

metaM lpchol hs e
name: lysophosphatidylcholine
has only substance units: false
is: CHEBI:60479
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247

metaR DASCBR
modifier: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000176
name: dehydroascorbate reductase
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is version of: http://identifiers.org/ec-code/1.8.4.1
product: MODEL1310110035#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0cae3714_e29f_422b_916f_45de00a7db0d
is: O15488
initial concentration: NaN
constant: false
is: SBO:0000252
name: GYG2
boundary condition: true
is encoded by: hsa:8908
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d04f2faa_d315_460d_b1e3_b4bc9bbf7e4d
is: O14495
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8613
name: PPAP2B
type: Species

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_82e751dd_f3a5_4a2b_9ea1_a21de1e306b0
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: VNN3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55350
has only substance units: false

metaM xylu D c
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17140
name: D-xylulose
is: HMDB01644
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0
type: Species

metaM pail345p hs c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
has only substance units: false
is: CHEBI:57836
type: Species
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981

metaM sebcoa x
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
name: sebacoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110035#_5768efbf_ea14_4699_80ec_703c265b441d
name: ACOT4
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:122970
boundary condition: true
is: Q8N9L9
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM CE4794 m
constant: false
name: cis-6-dodecenoyl-CoA
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57923
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR GLCt1r
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
name: glucose transport (uniport)
is described by: ECO:0000269

metaM cspg a e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00106
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00300
constant: false
is: CHEBI:17568
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM lpchol hs c
type: Species
initial concentration: 1.0
is: CHEBI:60479
is: SBO:0000247
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
name: lysophosphatidylcholine
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaM leuktrD4 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
is: CHEBI:28666
name: Leukotriene D4
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_5726d9a7_c480_42ed_82e1_23b549730631
boundary condition: true
is: SBO:0000252
name: DDOST
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: P39656
constant: false
is encoded by: hsa:1650

http://identifiers.org/biomodels.db/MODEL1310110035#_7516ceed_644f_459e_aa3e_42c63b744bad
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P23378
is encoded by: hsa:2731
type: Species
name: GLDC

metaM galgluside hs g
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C00015
is: HMDB00295
type: Species
name: galactosyl glucosyl ceramide
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162

metaR ADSL1
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110035#
type: Reaction
reversible: false
product: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
name: adenylosuccinate lyase

metaM HC02023 r
is: CHEBI:46898
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: Cholesterol-ester-ol
constant: false

metaR NACDe
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR r1381
reversible: true
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
is: SBO:0000176
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110035#

metaM 7thf e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
initial concentration: 1.0
has only substance units: false
is: HMDB06559
type: Species
boundary condition: false
constant: false

metaM udpglcur c
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
boundary condition: false
is: HMDB00935
is: CHEBI:58052
constant: false
name: UDP-D-glucuronate
has only substance units: false
type: Species
is: C00167
initial amount: NaN
initial concentration: 1.0

metaR GBAl
name: Glucosylceramidase
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.45
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110035#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110035#_8ca1a143_7d99_4c01_8fb7_73afe0652ca3
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P16278
is encoded by: hsa:2720
has only substance units: false
name: GLB1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_124324ba_79be_4233_87fe_199207aa5641
boundary condition: true
is: Q9NY65
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1962
is: SBO:0000252
name: EHHADH

metaR MM6B2g
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110035#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110035#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR r1380
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaR THCHOLSTOICtm
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110035#
fast: false

metaM sphings l
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57756
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
is: HMDB00252
name: sphingosine(1+)

metaR G14T5g
reactant: MODEL1310110035#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110035#
type: Reaction

metaR PYRt2m
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
fast: false
name: pyruvate mitochondrial transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

http://identifiers.org/biomodels.db/MODEL1310110035#_f9d0def3_4398_48a3_a941_455ee99b6de3
is: SBO:0000252
is encoded by: hsa:125061
is: Q63HM1
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: AFMID
boundary condition: true
initial amount: NaN

metaM leuktrD4 e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28666
name: Leukotriene D4
initial amount: NaN
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false

metaR PNTOte
name: Transport of (R)-Pantothenate
reactant: MODEL1310110035#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110035#

metaM hexe3coa x
name: 3-hexenoylcoa
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_75af79f8_cd22_43da_a945_1fc4729f37b5
constant: false
name: ATP5J2
is: P56134
is encoded by: hsa:9551
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR RE3556C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
fast: false
reversible: true
name: RE3556

http://identifiers.org/biomodels.db/MODEL1310110035#_bd18c158_7ea0_454e_b4ee_0e5fb7a4f91f
type: Species
constant: false
is: E9KL44
is: SBO:0000252
is encoded by: hsa:3030
boundary condition: true
name: HADHA
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_0c61810a_6c8a_4895_9790_fa4811861299
boundary condition: true
is encoded by: hsa:AI653169
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI653169_1_c
has only substance units: false
type: Species

metaM s7p c
name: Sedoheptulose 7-phosphate
is: C05382
boundary condition: false
is: SBO:0000247
is: CHEBI:57483
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: HMDB01068
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_a9c6c7d9_0d79_4a4b_959c_28cbbb1664b9
name: PDE4A
initial amount: NaN
type: Species
has only substance units: false
is: P27815
is: SBO:0000252
is encoded by: hsa:5141
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_dd84ef40_ad16_4920_8b1e_b15137e00af8
has only substance units: false
initial concentration: NaN
is: O94788
boundary condition: true
type: Species
is encoded by: hsa:8854
initial amount: NaN
name: ALDH1A2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_ab531da5_7b58_4903_ab92_579b090f025e
constant: false
type: Species
name: SCD5
initial concentration: NaN
is: SBO:0000252
is: Q86SK9
is encoded by: hsa:79966
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0129
fast: false
reversible: true
modifier: MODEL1310110035#
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_02cb8905_26af_4f35_8caa_038b19bdcb31
is: P31937
boundary condition: true
name: HIBADH
is: SBO:0000252
type: Species
is encoded by: hsa:11112
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM dgdp c
boundary condition: false
is: CHEBI:58595
initial amount: NaN
has only substance units: false
constant: false
name: dGDP
is: C00361
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0
is: HMDB00960

metaR M7MASNBterg
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110035#_d9f9c68f_540d_4259_b190_b65f9c9ea860
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:50484
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: Q7LG56
name: RRM2B

metaR CYTK5n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
name: cytidylate kinase (CMP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110035#_73d32e7b_7af4_4bcc_ad3e_0092ee5dfbbe
initial concentration: NaN
constant: false
name: NDUFA1
initial amount: NaN
is encoded by: hsa:4694
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q6IBB5

metaR BILGLCURtr
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
type: Reaction

metaM gal l
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: D-galactose
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_e790b513_a92b_41b9_8195_f8eb4223343e
has only substance units: false
initial concentration: NaN
is: Q9NRX3
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NDUFA4L2
type: Species
is encoded by: hsa:56901

http://identifiers.org/biomodels.db/MODEL1310110035#_ad6d4fac_133a_43b1_8d4d_d102d43f5aa4
is encoded by: hsa:128
boundary condition: true
is: Q6IRT1
initial concentration: NaN
name: ADH5
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR r0990
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
product: MODEL1310110035#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
name: Postulated transport reaction

metaR RE1522M
reversible: true
name: RE1522
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#

metaR RE2974C
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.149
is: SBO:0000176
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
name: RE2974

http://identifiers.org/biomodels.db/MODEL1310110035#_1d3ba474_2827_48d5_897e_f7ec2627602d
initial concentration: NaN
initial amount: NaN
is: Q16842
name: ST3GAL2
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6483
constant: false
is: SBO:0000252

metaR CYSPHELAT2tc
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR PTCRTD
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
fast: false
reversible: true
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
name: diffusion of putriscine into the endothelial cells

metaM mlthf m
is: C00143
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
constant: false
is: HMDB01533
is: CHEBI:15636

metaR DURIK1
reversible: false
type: Reaction
reactant: MODEL1310110035#
name: deoxyuridine kinase (ATP:Deoxyuridine)
product: MODEL1310110035#
is described by: ECO:0000254
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false

metaM galgluside hs c
is: HMDB06535
constant: false
name: galactosyl glucosyl ceramide
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_d206a8d6_1371_4848_a906_71a4841b3447
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: PDE9A
is encoded by: hsa:5152

metaR AG13T5g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_d04b1623_bf64_4fbb_b65d_10a9617644f0
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: P30837
is encoded by: hsa:219
is: SBO:0000252
name: ALDH1B1

metaM dgtp n
name: dGTP
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16497
is: HMDB01440
initial concentration: 1.0
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
has only substance units: false

metaR ADSL2
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
name: adenylosuccinate lyase
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110035#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110035#_f7e4c56e_820e_4f2a_9fa2_1060c5d9391c
boundary condition: true
initial amount: NaN
name: PLA2G2E
is: Q9NZK7
constant: false
is encoded by: hsa:30814
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR FAOXC101x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR r1619
fast: false
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110035#
is described by: ECO:0000000

metaM ksi pre8 g
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:28067
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 8
initial concentration: 1.0

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaM cs e l
constant: false
type: Species
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: CHEBI:36005
is: HMDB02183
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
boundary condition: false
initial amount: NaN

metaR MI1345PP
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_431f09f6_9bea_40c9_ba42_413b41e7e090
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:10195
name: ALG3
boundary condition: true
has only substance units: false
constant: false

metaM dgtp m
has only substance units: false
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN
name: dGTP
is: C00286
is: HMDB01440
constant: false
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
boundary condition: false

metaM tetpent6coa x
has only substance units: false
constant: false
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false
is: C16172
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_7c2c7fbe_7f9b_45d7_bf6b_0c820349c9b0
name: NOS3
is: A0S0A7
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4846
has only substance units: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_8ccdf75d_79ba_437c_aa9d_cab5f3c67e76
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:43
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ACHE

metaR RE1447M
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction

metaR SADT
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
is described by: ECO:0000269
reversible: false
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction

metaM acrn c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
boundary condition: false
name: O-acetylcarnitine
initial amount: NaN
is: HMDB00201
constant: false
type: Species
has only substance units: false

metaM nad c
initial amount: NaN
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: CHEBI:57540
constant: false
is: C00003
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false

metaR TCHOLAte
name: bile acid intracellular transport
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000

metaM 5dhf e
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
boundary condition: false
initial concentration: 1.0
is: HMDB06487
constant: false
name: pentaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110035#_ffeabbdb_7aaa_4476_9fef_590e2c7e55e9
is encoded by: hsa:7359
boundary condition: true
name: _7359_1_c
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_a471ab62_c4f9_4166_8cdc_a7f852fdca25
has only substance units: false
is encoded by: hsa:8534
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: CHST1
is: O43916
is: SBO:0000252
type: Species

metaM 10fthf7glu e
is: HMDB00972
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57454
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN

metaM mmcoa S m
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: CHEBI:57327
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: (S)-methylmalonyl-CoA(5-)
is: HMDB02310

metaM HC01007 x
name: L-Octanoylcarnitine
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
type: Species
is: SBO:0000247
is: CHEBI:18102
constant: false
has only substance units: false
initial concentration: 1.0

metaM nadh c
has only substance units: false
is: HMDB01487
is: C00004
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
is: CHEBI:57945

metaR NACHEX23ly
product: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reversible: false
reactant: MODEL1310110035#

metaM ksi deg10 l
constant: false
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
is: HMDB00812
type: Species
has only substance units: false
is: CHEBI:16953
is: SBO:0000247
name: keratan sulfate I, degradation product 10
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r1626
fast: false
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_3d94823f_632f_47d3_8108_e483fd29dae7
boundary condition: true
constant: false
is: P28329
initial concentration: NaN
type: Species
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CHAT

metaR FAOXC204C205x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_c89f1d2a_3fc3_410e_8734_a644e5c5ddd5
has only substance units: false
type: Species
boundary condition: true
constant: false
name: GGT1
is: P19440
initial amount: NaN
is encoded by: hsa:2678
is: SBO:0000252
initial concentration: NaN

metaR MI14P4P
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reactant: MODEL1310110035#
is described by: ECO:0000000
name: inositol-1,4-bisphosphate 4-phosphatase
fast: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_444dc2a3_3f7f_4dcc_9bf5_e355ca87510e
is: P19634
boundary condition: true
name: SLC9A1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6548
initial concentration: NaN
type: Species
constant: false

metaR r0549
is: SBO:0000176
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
type: Reaction

metaR r1934
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_814858e1_d8ad_4552_8e2a_cd8e22655666
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7360
is: SBO:0000252
initial amount: NaN
name: UGP2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_05f759f1_351e_4760_af45_9ba5d78432b8
constant: false
type: Species
is encoded by: hsa:522
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6NZ59
is: SBO:0000297
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR FORMCOAtx
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
name: formyl coa transport
product: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_6a29d039_192b_4f9b_a615_fa267a055e79
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SI
is: P14410
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6476

metaR r1627
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_36c3c1f7_85f4_43e4_bd0c_3eed1d09d2f7
constant: false
has only substance units: false
is: Q96G03
is: SBO:0000252
name: PGM2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55276
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_dae5b8a8_8e8d_48d4_9d85_2583051aa0ac
type: Species
initial amount: NaN
name: COX7A2L
is encoded by: hsa:9167
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q6FGA0

metaR THD1m
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.6.1.2
is described by: ECO:0000269
type: Reaction
name: NAD(P) transhydrogenase
modifier: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false
reversible: true

metaM dlnlcg e
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN
is: CHEBI:53486
has only substance units: false
is: HMDB02925
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: dihomo-gamma-linolenic acid (n-6)
constant: false
type: Species

metaR VALt5m
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110035#
name: Valine reversible mitochondrial transport

metaM odecoa x
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
constant: false
initial concentration: 1.0
name: oleoyl-CoA(4-)
has only substance units: false
is: CHEBI:57387

metaR PSSA2 hs
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
type: Reaction
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is: SBO:0000176
fast: false

metaM acgbgbside hs g
is: CHEBI:17411
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB00215
name: beta GalNAc globoside
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR r0142
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#

metaR RE2988X
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
reactant: MODEL1310110035#
name: RE2988
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR OMPDC
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110035#
reversible: false
fast: false
is: SBO:0000176
type: Reaction

metaM retinal c
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:15035
is: HMDB01358
initial amount: NaN
boundary condition: false
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247
has only substance units: false

metaR C3STDH1r
type: Reaction
modifier: MODEL1310110035#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
reversible: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110035#_160e241d_d62d_4ec5_bac5_e3a8ec1fb8f7
is: Q06136
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2531
type: Species
initial concentration: NaN
is: SBO:0000252
name: KDSR
boundary condition: true

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaR r1628
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#

metaR DCSPTN1CRNt
fast: false
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110035#
reversible: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_e4e075bd_05ce_471e_96ae_9c9f6df81427
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: _BC005314_1_x
constant: false
initial concentration: NaN
is encoded by: hsa:BC005314

metaR GLCNACASE2ly
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR PGDI
reversible: true
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2
type: Reaction
name: Prostaglandin-H2 D-isomerase [Precursor]
is described by: ECO:0000269
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110035#

metaR GMPR
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
is version of: http://identifiers.org/ec-code/1.7.1.7
reactant: MODEL1310110035#
fast: false
name: GMP reductase

http://identifiers.org/biomodels.db/MODEL1310110035#_7b09fed8_e369_48b9_82f0_e811cdd98fa4
initial concentration: NaN
is: O14521
type: Species
boundary condition: true
is encoded by: hsa:6392
is: SBO:0000252
initial amount: NaN
name: SDHD
constant: false
has only substance units: false

metaR RE3004M
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE3004
product: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_aff9ef24_90a9_450d_bc29_2ccac4ea1e4e
initial concentration: NaN
is: SBO:0000252
is: Q9ULC5
is encoded by: hsa:51703
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110035#_14884117_f940_4842_86a1_b8935aba83a5
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:51227
initial concentration: NaN
type: Species
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

http://identifiers.org/biomodels.db/MODEL1310110035#_6e39a714_7a76_4907_9136_1b72c8ef7a0a
constant: false
initial amount: NaN
name: DHCR7
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1717
is: Q9UBM7
boundary condition: true
is: SBO:0000252

metaM omhpal r
boundary condition: false
notes: FORMULA: C16H30O3 CHARGE: -1
is: HMDB06294
is: SBO:0000247
type: Species
constant: false
name: w-hydroxypalmiticacid
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR MALTSULtm
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
name: Malate:thiosulfate antiport, mitochondrial
fast: false
is described by: ECO:0000269
modifier: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR r1629
type: Reaction
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_6faa55b0_0e21_4091_9da2_6ad52c47113d
has only substance units: false
initial amount: NaN
is encoded by: hsa:8140
name: SLC7A5
type: Species
is: Q8IV97
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_a96adada_c0f1_47e9_bce2_434b7b378e38
is: SBO:0000252
constant: false
has only substance units: false
is: Q6NVY1
is encoded by: hsa:26275
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: HIBCH

http://identifiers.org/biomodels.db/MODEL1310110035#_8908c20d_0a47_4860_a1b4_f7507892973c
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P59796
is encoded by: hsa:257202
constant: false
type: Species
boundary condition: true
name: GPX6

metaM 5fthf m
has only substance units: false
is: CHEBI:57457
boundary condition: false
is: HMDB01562
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)
constant: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
initial amount: NaN

metaM ksi deg3 l
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: CHEBI:30825
boundary condition: false
is: HMDB00573
name: keratan sulfate I, degradation product 3
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM docosahexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
name: 3,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_4af3b909_e40f_4e92_aec0_67459454e071
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9H310
is: SBO:0000252
name: RHBG
is encoded by: hsa:57127
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3e9597e7_dc55_4dcc_bf35_5f853fa3b968
is: Q9NUD9
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: PIGV
is encoded by: hsa:55650
is: SBO:0000252
has only substance units: false

metaR CMPACNAtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
fast: false
name: CMP-Sia nuclear export
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#

metaM Ser Gly Ala X Gly l
is: HMDB02183
is: CHEBI:36005
notes: FORMULA: XH CHARGE: 0
constant: false
type: Species
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

metaM lnlnca e
initial amount: NaN
constant: false
is: CHEBI:32387
is: HMDB01388
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
name: alpha-linolenate
boundary condition: false

metaM core3 g
type: Species
initial concentration: 1.0
has only substance units: false
name: Core 3
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
constant: false
is: CHEBI:16250

metaR r1622
modifier: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaR ARACHDt2
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
name: fatty acid transport via diffusion
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#

metaR FUMTSULtm
name: Fumarate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110035#
product: MODEL1310110035#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM 3hibutcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: HMDB01052
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
is: CHEBI:28259
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:26174
name: i-antigen

metaR r0545
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39

metaR r0698
is described by: ECO:0000000
type: Reaction
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
kinetic law: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is: SBO:0000176
product: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27

metaM dgtp e
is: SBO:0000247
type: Species
is: HMDB01440
has only substance units: false
is: CHEBI:16497
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
boundary condition: false
constant: false
initial concentration: 1.0

metaR GALt4
reactant: MODEL1310110035#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
product: MODEL1310110035#
name: galactose transport via sodium symport
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
fast: false

metaM dd5ecoa m
is: HMDB13028
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: C01942
is: SBO:0000247
boundary condition: false
type: Species
name: 5-dodecenoylcoa
initial concentration: 1.0

metaR GHMT2r
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.1.2.1
name: glycine hydroxymethyltransferase, reversible
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_30052eff_4465_475b_b90d_4978cf75f56c
is: SBO:0000252
is encoded by: hsa:84532
is: Q9NUB1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: ACSS1

metaR r1623
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110035#
product: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_9fb3a38a_cad3_4c99_973e_2d5f2e309134
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
constant: false
name: PDE9A
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR SIAT4Bg
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

metaR HSD17B8r
name: 17-beta-hydroxysteroid dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.62
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
reversible: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_4f43e442_d568_4d84_938a_9a6a2701ab20
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6576
is: SBO:0000252
constant: false
is: D9HTE9
type: Species
boundary condition: true
name: SLC25A1

metaM mev R c
is: HMDB00227
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36464
name: (R)-mevalonate
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343

metaR NAGAlby
reactant: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
type: Reaction
fast: false
product: MODEL1310110035#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: N-acetylgalactosaminidase, beta-

metaR FAS100COA
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty acyl-CoA synthase (n-C10:0CoA)
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is described by: ECO:0000269

metaR r1624
kinetic law: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM 5adtststerone e
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
is: HMDB02961

metaM lnlnca c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01388
name: alpha-linolenate
boundary condition: false

metaR PROSTGE2t2
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
name: prostaglandin uniport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true
product: MODEL1310110035#

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
fast: false

metaR B3GNT12g
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176
reversible: false
modifier: MODEL1310110035#
fast: false

metaR GALASE4ly
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176

metaM acgbgbside hs l
has only substance units: false
is: CHEBI:17411
constant: false
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: beta GalNAc globoside
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00215
boundary condition: false

metaR FAOXC18280m
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
reversible: false
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false

metaR TRIODTHYt2
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110035#
is: SBO:0000185
fast: false
modifier: MODEL1310110035#
name: T3 transport via facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110035#_3bedcff7_be27_4517_8e82_5efbdb92412d
has only substance units: false
constant: false
type: Species
is: Q9Y233
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10846
name: PDE10A
boundary condition: true
initial concentration: NaN

metaR r1512
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#

metaR URIt5le
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: uridine transport in via sodium symport (1:2)
modifier: MODEL1310110035#

metaR r1625
reversible: true
reactant: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110035#
is described by: ECO:0000000
fast: false
product: MODEL1310110035#

metaR MTHFD2m
reversible: true
fast: false
modifier: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110035#
is described by: ECO:0000254

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR HOXG
modifier: MODEL1310110035#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
fast: false
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.14.99.3
product: MODEL1310110035#
reversible: false
kinetic law: MODEL1310110035#
type: Reaction
is: SBO:0000176
name: Heme oxygenase 1

http://identifiers.org/biomodels.db/MODEL1310110035#_07fc66ff_44ab_46b5_8944_bc97f40006cf
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9NUI1
is encoded by: hsa:26063
has only substance units: false
name: DECR2
is: SBO:0000252
boundary condition: true
type: Species

metaM 5adtststerone c
initial concentration: 1.0
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC101m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM HC00718 c
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR FAOXTC142TC122m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR NDPK1m
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000254
reversible: true
is: SBO:0000176
product: MODEL1310110035#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction

metaM c12dccoa x
boundary condition: false
constant: false
name: dodecanedioylcoa
is: HMDB04047
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: C14143
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r2497
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
kinetic law: MODEL1310110035#
type: Reaction
reversible: false
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000
product: MODEL1310110035#

metaM 3octpencoa m
is: SBO:0000247
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
constant: false
initial concentration: 1.0
name: 3,6,9,12,15-octadecapentenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
boundary condition: false
has only substance units: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_b46c8dc4_576b_4fd3_afc9_19366799fd92
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3028
type: Species
is: Q99714
initial amount: NaN
name: HSD17B10
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_0d3d5026_c112_47a7_a619_e8b4416d246a
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: GGT2
is encoded by: hsa:728441
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_fbc9c3ff_36b6_44f3_9a0d_e6388524f416
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:27306
has only substance units: false
name: HPGDS
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O60760

metaR CDIPTr
is version of: http://identifiers.org/ec-code/2.7.8.11
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
type: Reaction
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM dgdp m
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
initial concentration: 1.0
is: CHEBI:58595
initial amount: NaN
is: HMDB00960
has only substance units: false
constant: false
boundary condition: false

metaR SPHS1Ptr
reactant: MODEL1310110035#
fast: false
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185
type: Reaction
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
product: MODEL1310110035#

metaR IMPC
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110035#
name: IMP cyclohydrolase
type: Reaction
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_5b4d240d_94c5_455c_acae_9633db6269c0
is encoded by: hsa:80308
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FLAD1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR NDPK1n
reversible: true
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
product: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f5c8f6db_3f2e_4821_99f9_5b8449655a41
is: SBO:0000252
type: Species
boundary condition: true
name: SLC36A1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:206358
constant: false
initial amount: NaN
is: Q1LZ56

metaR r0541
reactant: MODEL1310110035#
fast: false
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110035#
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_3be13fc0_b20e_4342_a564_276dbcc380ad
boundary condition: true
is encoded by: hsa:10317
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: B3GALT5
type: Species
constant: false
initial amount: NaN

metaM dgdp n
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00960
name: dGDP(2-)

metaR COAtr
is: SBO:0000185
reversible: true
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
product: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false

metaM nad x
is: C00003
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
is: CHEBI:57540
is: HMDB00902
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3305

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM CE5121 m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
name: trans-3-decenoyl-CoA
initial amount: NaN
boundary condition: false
is: CHEBI:57449
type: Species

metaR CMPSASn
reactant: MODEL1310110035#
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
type: Reaction
modifier: MODEL1310110035#
is described by: ECO:0000304
name: CMP sialic acid synthase, nuclear

metaM 12ppd S c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
constant: false
is: CHEBI:29002
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-propane-1,2-diol
is: HMDB06213
boundary condition: false

metaR GGH 6DHFe
product: MODEL1310110035#
reactant: MODEL1310110035#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
reversible: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.19.9

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR RE3627M
name: RE3627
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110035#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#

metaM 2dodtricoa m
name: 2,6,9-dodecatrienoylcoa
constant: false
is: C05279
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123

metaM nadh m
is: C00004
is: http://identifiers.org/pubchem.compound/3306
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57945
is: HMDB01487
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN

metaM CE4795 x
constant: false
initial concentration: 1.0
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
boundary condition: false
has only substance units: false
is: CHEBI:57923
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795

http://identifiers.org/biomodels.db/MODEL1310110035#_e4e48438_77f6_493a_9ade_3f3ae2579056
is: P78356
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: PIP4K2B
is encoded by: hsa:8396
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_b9f4e829_5282_4786_a517_552b1ea01407
is: SBO:0000252
is: O00217
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:4728
initial amount: NaN
initial concentration: NaN
name: NDUFS8
constant: false

metaR FAOXC102C101x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaM dgtp c
initial amount: NaN
name: dGTP
boundary condition: false
has only substance units: false
is: CHEBI:16497
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
constant: false
initial concentration: 1.0
is: C00286
type: Species

metaR DOLPMT3 Uer
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.260
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_5a12b4b4_85e7_4258_8247_ecc8f295219b
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ATP2B2
type: Species
initial concentration: NaN
is: Q4J699
is encoded by: hsa:491

metaR PGK
modifier: MODEL1310110035#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.2.3
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110035#
name: phosphoglycerate kinase

metaM f1p c
constant: false
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: SBO:0000247
is: HMDB01076
initial concentration: 1.0
boundary condition: false
is: CHEBI:18105
initial amount: NaN
is: C01094
name: D-Fructose 1-phosphate
type: Species

metaR ACCOAtn
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: acetyl-CoA transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_4f415360_299e_4700_9e4d_95dc39816942
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:H17063
constant: false
name: _H17063_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_b469bc22_0028_4a0f_8502_44bf98e6da24
is: P30613
is encoded by: hsa:5313
initial concentration: NaN
name: PKLR
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM 20ahchsterol m
is: HMDB06283
is: CHEBI:1296
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 20-hydroxycholesterol
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species
constant: false

metaR r1621
is described by: ECO:0000000
product: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction
kinetic law: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_0828f261_1057_4bc6_bfbe_7c7535a5276f
is: P43353
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ALDH3B1
is encoded by: hsa:221
constant: false
type: Species

metaR Coqe
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
type: Reaction
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_dd75d338_5c2d_42b7_a55c_153ba10792ed
type: Species
is: SBO:0000252
initial concentration: NaN
is: P27144
constant: false
initial amount: NaN
is encoded by: hsa:205
has only substance units: false
name: AK4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_e306fa86_961a_4f61_b24f_4d33b2b05fc5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5315
type: Species
has only substance units: false
is: P14618
boundary condition: true
name: PKM2

metaM HC01407 m
constant: false
is: CHEBI:28276
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
has only substance units: false

metaR r2062
product: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110035#_bb2f39bc_918e_4c0c_9543_bd3eb27f479e
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AL038231
boundary condition: true
has only substance units: false
type: Species
name: _AL038231_1_c
is: SBO:0000252
constant: false

metaR ACGALtlg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
kinetic law: MODEL1310110035#
name: N-acetyl-galactosamine intracellular transport
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_7450fb98_7476_45e2_8b1d_49762b5827be
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:56606
name: SLC2A9
is: Q9NRM0
boundary condition: true
constant: false

metaM nac c
is: CHEBI:0
boundary condition: false
name: Nicotinate
constant: false
has only substance units: false
is: HMDB01488
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: C00253

metaM inost c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
constant: false
is: HMDB00211
is: SBO:0000247
type: Species
name: myo-inositol
boundary condition: false
is: CHEBI:17268
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_bdd85026_4719_4444_998e_78e716a58e82
is: Q6FGV9
has only substance units: false
initial concentration: NaN
name: PMVK
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:10654

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_ec944439_21a9_42ec_bc81_336581e3a31b
constant: false
is: P55084
is encoded by: hsa:3032
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HADHB
boundary condition: true
type: Species

metaR COAtn
reversible: true
is: SBO:0000185
product: MODEL1310110035#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
name: coenzyme A transport, nuclear
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR FAOXC164C165m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM lac D e
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
is: HMDB01311
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16004

metaR PGI
type: Reaction
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/5.3.1.9
is: SBO:0000176
name: glucose-6-phosphate isomerase
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_a024becc_ed0c_4959_acf1_5c3ee5dd5088
is encoded by: hsa:4967
is: B4E3E9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: OGDH
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_cfe49e0b_100d_4763_b30a_21a749fd02af
is encoded by: hsa:259230
initial amount: NaN
boundary condition: true
is: D3DWC4
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: SGMS1

http://identifiers.org/biomodels.db/MODEL1310110035#_38481c94_3476_41e4_86c7_beb2f743cc50
is encoded by: hsa:AI972237
initial concentration: NaN
has only substance units: false
constant: false
name: _AI972237_1_c
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM g1p e
is: SBO:0000247
is: HMDB01586
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
constant: false
type: Species
name: alpha-D-glucose 1-phosphate(2-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:58601

metaR CLPNDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion

metaR FAOXC164C143x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaM HC01007 m
is: SBO:0000247
constant: false
name: L-Octanoylcarnitine
initial concentration: 1.0
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:18102
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_be6b601d_4144_43cd_848b_c3c0cdb90c6f
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PKLR
initial amount: NaN
is: SBO:0000252
is: P30613
is encoded by: hsa:5313
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_951ff861_1172_4f3c_b8ad_3acab8dac0d0
has only substance units: false
constant: false
is: Q16774
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: GUK1
is encoded by: hsa:2987

metaM ksi pre14 g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 14
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
boundary condition: false
is: CHEBI:28067
has only substance units: false

metaM dlnlcg c
has only substance units: false
initial concentration: 1.0
constant: false
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
type: Species
is: CHEBI:53486
is: HMDB02925
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: SBO:0000247

metaM inost e
is: HMDB00211
boundary condition: false
initial concentration: 1.0
name: myo-inositol
constant: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_0ae055f3_0052_4e78_9401_dd366876fd50
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NAGA
is: P17050
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4668
has only substance units: false

metaR NACHEX14ly
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110035#
fast: false
product: MODEL1310110035#
is: SBO:0000176
type: Reaction

metaM ksii core2 pre7 g
has only substance units: false
type: Species
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C67H108N5O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
initial concentration: 1.0
boundary condition: false
constant: false
is: C00130
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ac89c4c1_d5a9_42d1_b125_cb9d6421fecd
boundary condition: true
name: HSD17B4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3295
is: E9PB82
type: Species
initial amount: NaN

metaR CMPACNAtg
fast: false
is described by: ECO:0000269
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
name: CMP-Sia Golgi transport via CMP antiport
reversible: true
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR COAtp
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110035#
name: coenzyme A transport, peroxisomal

metaM c4crn x
is: http://identifiers.org/pubchem.compound/213144
constant: false
type: Species
is: HMDB02013
boundary condition: false
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
initial amount: NaN
name: butyryl carnitine
initial concentration: 1.0
is: SBO:0000247
is: C02862

metaM nad r
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: NAD(1-)
is: CHEBI:57540
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
type: Species
initial amount: NaN

metaR 4HPRO LTte
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
fast: false
name: Transport of trans-4-hydroxy-L-proline
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110035#
type: Reaction

metaM lac D c
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16004
name: (R)-lactate
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ppp9 m
boundary condition: false
is: CHEBI:36159
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB00241
name: Protoporphyrin

http://identifiers.org/biomodels.db/MODEL1310110035#_15b8c7f5_c647_42c6_aad7_c4fd42b87757
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7355
constant: false
name: SLC35A2
is: SBO:0000252
is: P78381
boundary condition: true
has only substance units: false
type: Species

metaM g1p c
name: D-Glucose 1-phosphate
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00103
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58601

metaM 4mlacac c
type: Species
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
has only substance units: false
name: 4-maleylacetoacetate
constant: false
is: SBO:0000247
is: CHEBI:17105
initial amount: NaN
boundary condition: false
is: HMDB02052
initial concentration: 1.0

metaR ACCOAtr
kinetic law: MODEL1310110035#
fast: false
name: acetyl-coa transport
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
modifier: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_a9a9c98d_102c_4d86_8108_d34bf2a9aa8e
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: ADH1C
constant: false
initial concentration: NaN
is: P00326
is: SBO:0000252
is encoded by: hsa:126

metaR NACHEX22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110035#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110035#
fast: false

metaR r0842
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
product: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110035#

metaR ALAGLNNaEx
fast: false
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110035#
is: SBO:0000185
reversible: false
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
type: Reaction

metaR FTCD
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction
name: formimidoyltransferase cyclodeaminase
fast: false
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_eb073f3c_de2a_42e5_a044_e6f9337ccbf5
is encoded by: hsa:9963
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC23A1
initial concentration: NaN
constant: false
initial amount: NaN

metaR APOCF
reversible: false
name: Apocarboxylase formation
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176

metaR APRGSTRNte
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: hydroxyprogesterone transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_e6acd68a_0f1e_4ae7_92cd_3380117fc94c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3073
boundary condition: true
is: P06865
type: Species
initial amount: NaN
name: HEXA

metaR PUNP7
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
name: purine-nucleoside phosphorylase (Xanthosine)
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#

metaM camp c
constant: false
is: CHEBI:58165
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00058
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
type: Species
boundary condition: false

metaM nadh r
constant: false
name: NADH(2-)
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
has only substance units: false
is: CHEBI:57945
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a0aee986_7ba8_4329_b0fd_0e6672fd22c2
is encoded by: hsa:644
boundary condition: true
initial concentration: NaN
name: BLVRA
type: Species
is: P53004
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR MTHFDm
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110035#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110035#_5d5500f0_3c0c_437a_aa75_398b89b612b3
name: AUH
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:549
initial concentration: NaN
has only substance units: false
type: Species
is: Q13825

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_68b4bf94_3195_43ef_96cd_af836e0e58a7
name: AADAT
has only substance units: false
type: Species
is: Q8N5Z0
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51166
initial amount: NaN
initial concentration: NaN

metaR r2405
kinetic law: MODEL1310110035#
is: SBO:0000185
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110035#
is described by: ECO:0000000

metaR DESAT18 10
fast: false
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false

metaR ARTCOAL3
is described by: ECO:0000000
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
name: R group coenzyme a ligase

http://identifiers.org/biomodels.db/MODEL1310110035#_5e9267d1_04a4_44eb_b94c_a744b76e0b9c
initial amount: NaN
is: P33261
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1557
name: CYP2C19

metaR PRODt2r
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false
name: D-proline reversible transport via proton symport
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000304
product: MODEL1310110035#

metaR PUNP6
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyinosine)
fast: false
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaR DHAAt1r
reversible: true
modifier: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000269
name: dehydroascorbate transport (uniport)
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
fast: false

metaM tddedicoa m
constant: false
is: http://identifiers.org/pubchem.compound/5280771
initial amount: NaN
has only substance units: false
name: trans3,6dodecadienoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaR BTNPLm
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000176
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
type: Reaction
product: MODEL1310110035#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110035#

metaR SBTR
reversible: false
reactant: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110035#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000176
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110035#_47b5385a_2156_40c9_a851_eb4b9ed64919
name: NDUFB2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: H7C5B8
has only substance units: false
is encoded by: hsa:4708
type: Species
initial amount: NaN

metaM m6masnB2 g
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:30825
has only substance units: false
is: HMDB00573
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM pglyc hs c
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
name: phosphatidylglycerol(1-)
is: CHEBI:60523
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaM strdnc c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
has only substance units: false
boundary condition: false
name: stearidonic acid C18:4, n-3
is: SBO:0000247
is: C16300
constant: false
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547

metaR r1378
reactant: MODEL1310110035#
reversible: true
type: Reaction
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is: SBO:0000176
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR ACGAMK
is described by: ECO:0000269
fast: false
reactant: MODEL1310110035#
name: N-acetylglucosamine kinase
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: false
product: MODEL1310110035#

metaR A MANASEly
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
name: alpha-mannosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_290c1d94_6f10_43ad_a474_b6f6171c28e8
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ACADS
is: P16219
initial amount: NaN
is encoded by: hsa:35
constant: false

metaR FAOXC164C143m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_d3084b95_3914_4736_ae44_57d7e6e09feb
initial amount: NaN
type: Species
initial concentration: NaN
is: B8ZZR8
has only substance units: false
is encoded by: hsa:79017
constant: false
boundary condition: true
is: SBO:0000252
name: GGCT

http://identifiers.org/biomodels.db/MODEL1310110035#_8dd7afff_7fa9_425d_88fa_8ce43d694ae5
has only substance units: false
name: MTHFS
is: P49914
type: Species
is encoded by: hsa:10588
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR B3GNT313g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000254
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110035#

metaM nac e
initial concentration: 1.0
type: Species
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB01488
is: SBO:0000247
name: Nicotinate
has only substance units: false
constant: false
is: CHEBI:0

metaR r0840
is version of: http://identifiers.org/ec-code/1.14.13.70
is described by: ECO:0000000
fast: false
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
name: Free diffusion
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is: SBO:0000185
product: MODEL1310110035#
type: Reaction

metaR r2407
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110035#
reversible: false
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#

metaR r1377
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110035#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110035#_8e4ddb92_9de0_4dd7_959c_9b5c35b88197
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1892
name: ECHS1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P30084

metaM cspg b e
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17568
is: SBO:0000247
is: C00106
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB00300
constant: false
initial concentration: 1.0
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110035#_547de276_becd_4c6d_8ecd_6f3ecaee82e8
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR r0841
is: SBO:0000185
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.271
fast: false
product: MODEL1310110035#
reactant: MODEL1310110035#
name: Free diffusion
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_147454c5_5321_4268_a45a_7ac20281d1e9
constant: false
is: SBO:0000252
name: _AI640625_1_c
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI640625

http://identifiers.org/biomodels.db/MODEL1310110035#_4df6e974_0ca5_4766_a77d_1082fea612a3
constant: false
initial concentration: NaN
name: _X63359_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:X63359

http://identifiers.org/biomodels.db/MODEL1310110035#_22b8a64f_474f_4343_a751_423a7bca1ab2
boundary condition: true
is encoded by: hsa:271
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: AMPD2
type: Species
is: B2RB47
has only substance units: false

metaM dgchol x
type: Species
is: HMDB00637
is: CHEBI:36252
is: SBO:0000247
name: glycochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR DAG HSter
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
name: diacylglycerol ER export
kinetic law: MODEL1310110035#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_a8711bc7_8bf1_4172_8c6f_fbc57c69eada
has only substance units: false
name: NDUFB9
is: Q9Y6M9
is encoded by: hsa:4715
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_d99e6a17_657c_459f_8f86_ac9ba25e382b
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9H999
constant: false
is encoded by: hsa:79646
type: Species
name: PANK3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ee7239f3_2011_461c_ade9_2554e2022420
is: Q4F7X0
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:114
has only substance units: false
initial amount: NaN
name: ADCY8
boundary condition: true
is: SBO:0000252

metaM strdnc e
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: stearidonic acid C18:4, n-3
type: Species
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
is: SBO:0000247

metaR SPHMYLNtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#
name: sphingomyelin intracellular transport

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM pglyc hs e
initial amount: NaN
has only substance units: false
is: CHEBI:60523
name: phosphatidylglycerol(1-)
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110035#_0e7523af_dc7b_449f_9646_f1b00b968910
initial concentration: NaN
name: OGDHL
constant: false
boundary condition: true
initial amount: NaN
is: Q9ULD0
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:55753

metaR G14T16g
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_6c38bbd7_d3bf_4f20_8e16_17ccfb9a30f9
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:NM 013421
type: Species
name: _NM_013421_1_m
initial amount: NaN
constant: false
initial concentration: NaN

metaM ditp c
constant: false
is: HMDB03537
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61382
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_6d53893d_40de_4e6a_aa47_6156f1fa6344
type: Species
constant: false
boundary condition: true
name: GCAT
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:23464
is: E2QC23
initial concentration: NaN

metaR FAOXC2051843m
modifier: MODEL1310110035#
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110035#

metaR GLNS
product: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
is described by: ECO:0000254
name: glutamine synthetase

metaR RE0935E
name: RE0935
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17

metaM omhpal c
type: Species
boundary condition: false
is: HMDB06294
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
name: w-hydroxypalmiticacid
initial amount: NaN

metaR DURIt
name: deoxyuridine transport via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
fast: false

metaR GLYPHEHYc
product: MODEL1310110035#
name: hydrolysis of glycylphenylalanine
is: SBO:0000176
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
fast: false
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_7b28b2fd_92f3_4fbb_9491_5c286b17dcd3
constant: false
name: ETFDH
boundary condition: true
is: Q16134
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2110
is: SBO:0000252

metaR DCK2n
type: Reaction
reversible: true
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_f9db5a61_376e_4dd5_a44a_555fd11eb2cd
is: Q8NE62
has only substance units: false
is: SBO:0000252
type: Species
name: CHDH
constant: false
boundary condition: true
is encoded by: hsa:55349
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_73887e1e_7604_463b_ba27_4ae3d4ff888e
name: ARSA
is encoded by: hsa:410
initial amount: NaN
is: P15289
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaR FAOXC10C8m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_fae8446e_2b3a_451e_b3d5_bb2b7ce2126e
type: Species
is encoded by: hsa:8611
is: SBO:0000252
has only substance units: false
boundary condition: true
is: G3XA95
name: PPAP2A
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_6d49d6d8_2672_480e_bd79_21dc20e232f1
boundary condition: true
is: P19440
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GGT1
constant: false
has only substance units: false
is encoded by: hsa:2678

metaR NTD9
product: MODEL1310110035#
fast: false
type: Reaction
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000134
name: 5'-nucleotidase (GMP)
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

http://identifiers.org/biomodels.db/MODEL1310110035#_753a7c5e_a764_4c03_bd03_44301f7497e3
initial concentration: NaN
boundary condition: true
type: Species
name: CYP27A1
initial amount: NaN
is encoded by: hsa:1593
has only substance units: false
is: SBO:0000252
is: Q02318
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_fe8909cf_aa26_42fa_a151_a0c0b392ec0f
initial concentration: NaN
name: _AV717590_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:AV717590
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM ksi pre2 g
notes: FORMULA: C87H142N6O62X CHARGE: -1
name: keratan sulfate I biosynthesis, precursor 2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58053
has only substance units: false
is: HMDB00175
type: Species
is: C00130

metaR NTD8
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dGMP)
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false

metaM ksi pre9 g
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 9
has only substance units: false
is: SBO:0000247
is: C00130
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: HMDB00175

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: CoproporphyrinogenI
boundary condition: false
is: CHEBI:28607
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_7439f466_ca8b_49df_89cd_7bcbda9187c3
initial concentration: NaN
has only substance units: false
name: PDE3B
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5140
is: A7E2E5
boundary condition: true

metaM HC01007 c
is: CHEBI:18102
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-Octanoylcarnitine
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7dfcde6f_2afd_40a4_8acd_d5228f89b0c2
name: DPM1
is encoded by: hsa:8813
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: O60762
boundary condition: true
is: SBO:0000252
type: Species

metaR r0249
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110035#
modifier: MODEL1310110035#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reactant: MODEL1310110035#
is: SBO:0000176

metaR SUCRe
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110035#
name: sucrose hydrolyzing enxyme, extracellular
is described by: ECO:0000269
reversible: false
product: MODEL1310110035#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10

metaM tetd7ecoa m
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: HMDB13109
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 7-tetradecenoylcoa

metaR FAOXC201C181x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_095d79bb_b400_4bf8_88e9_3937d508ed16
initial concentration: NaN
is encoded by: hsa:3990
is: SBO:0000252
name: LIPC
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: A6H8L5

metaR r0246
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3ae2bd9b_976d_4654_8f41_51b9303c9ab1
initial concentration: NaN
is encoded by: hsa:284129
boundary condition: true
is: Q86WA9
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: SLC26A11
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_275e7f52_8bc8_4056_9ddf_42b3094bc91b
is encoded by: hsa:286297
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: _286297_1_c

http://identifiers.org/biomodels.db/MODEL1310110035#_90cce9a9_3127_437c_91df_f2f9c687ee8a
name: GALNT11
is: B3KWF4
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:63917
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_47a32769_f187_41e4_9929_8f7485cffe45
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q11201
name: ST3GAL1
type: Species
has only substance units: false
is encoded by: hsa:6482

http://identifiers.org/biomodels.db/MODEL1310110035#_04c5708a_0b8d_4a0f_9c77_1bb0db7bdb38
is: Q9Y227
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ENTPD4
type: Species
constant: false
is encoded by: hsa:9583

metaR ACNAMPH
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reversible: false
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_45435278_0c73_4b48_8f71_4715dbdf6f82
type: Species
initial concentration: NaN
is: Q99808
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:2030
initial amount: NaN
name: SLC29A1

metaR GALASE11ly
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110035#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110035#_105d34be_e331_452c_b906_a9a96c32a267
type: Species
boundary condition: true
name: NDUFA6
initial concentration: NaN
has only substance units: false
is: P56556
initial amount: NaN
constant: false
is encoded by: hsa:4700
is: SBO:0000252

metaR DHFR
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110035#
name: dihydrofolate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110035#
fast: false
is described by: ECO:0000254
reversible: true
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaR PLA2 2e
kinetic law: MODEL1310110035#
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
name: phospholipase A2
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.1.4
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
fast: false

metaR PSt3
name: phosphatidylserine transport
product: MODEL1310110035#
is: SBO:0000185
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false

metaR GLYCtm
reversible: true
name: glycerol transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000185
fast: false
reactant: MODEL1310110035#
product: MODEL1310110035#
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_714f19e4_be42_45d4_9d4b_66c2264e9065
is encoded by: hsa:10678
boundary condition: true
has only substance units: false
is: Q9NY97
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: B3GNT2

http://identifiers.org/biomodels.db/MODEL1310110035#_cf8b9816_2b91_4218_aaa5_cad526e6bc99
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3417
initial concentration: NaN
is: SBO:0000252
is: O75874
name: IDH1
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3fb0287e_0b49_4d15_bdb6_d45427714669
is: SBO:0000252
constant: false
name: AMY2B
is: P19961
initial amount: NaN
has only substance units: false
is encoded by: hsa:280
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_e94349a6_a77d_46b5_b8d7_f9b1ea514e88
name: _T83654_1_c
has only substance units: false
is encoded by: hsa:T83654
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_9606d4e9_5160_4f10_98c7_1dc86a1826b4
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: _D87002_1_m
is encoded by: hsa:D87002
is: SBO:0000252

metaM g2m8masn r
initial amount: NaN
type: Species
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: C05874
is: SBO:0000247
constant: false
boundary condition: false

metaM eicostetcoa c
initial amount: NaN
is: SBO:0000247
constant: false
is: C16164
has only substance units: false
initial concentration: 1.0
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_472e0eb6_1335_43ce_99c2_75a845b4f71c
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51227
name: PIGP
type: Species
boundary condition: true
initial amount: NaN

metaM tridcoa m
initial concentration: 1.0
is: HMDB13109
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: tridecanoylcoa
notes: FORMULA: C34H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110035#_3367fa47_6adc_4f19_b2e1_d41750648e94
has only substance units: false
initial concentration: NaN
name: _AI348006_1_c
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI348006
type: Species
constant: false

metaR METtec
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110035#
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)

metaR r0139
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110035#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110035#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2

metaR NTD5
modifier: MODEL1310110035#
product: MODEL1310110035#
fast: false
name: 5'-nucleotidase (dTMP)
reversible: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
kinetic law: MODEL1310110035#
is described by: ECO:0000134
reactant: MODEL1310110035#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction

metaM gchola c
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58235
is: HMDB00138
name: glycocholate
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921

metaR CYTK6n
is described by: ECO:0000269
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,CTP),nuclear
reactant: MODEL1310110035#
type: Reaction
is: SBO:0000176

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
is: SBO:0000176
reactant: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
product: MODEL1310110035#
is described by: ECO:0000269
name: phosphatidylinositol 4-phosphate phospholipase C
type: Reaction

metaR biomass reaction
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
is: SBO:0000185
name: Generic human biomass reaction
fast: false
is described by: ECO:0000134
reversible: false

metaM CE5786 e
is: CHEBI:27485
constant: false
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial concentration: 1.0
name: kinetensin
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02710
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_1601e2dd_e482_494d_b407_b9038df9d530
is: SBO:0000252
is encoded by: hsa:5634
type: Species
is: P11908
initial amount: NaN
name: PRPS2
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_a2855de9_6e50_4c82_bd40_667081d96d95
is: A5PKZ1
initial amount: NaN
is encoded by: hsa:11227
name: GALNT5
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR INSt
is: SBO:0000185
name: Inosine transport (diffusion)
is described by: ECO:0000269
product: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_8385601f_1734_41ec_9068_e1ca33786976
is encoded by: hsa:4125
has only substance units: false
constant: false
name: MAN2B1
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: O00754

metaM tetpent3 c
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: tetracosapentaenoic acid, n-3
is: HMDB06323
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
has only substance units: false

metaR G16MT L
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM dhdascb e
initial amount: NaN
is: CHEBI:58070
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01264
has only substance units: false
name: dehydroascorbide(1-)
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425

metaM odecoa m
constant: false
boundary condition: false
is: CHEBI:57387
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)

metaM hexdicoa x
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB02288
constant: false
is: SBO:0000247
name: hexadecanedioylcoa

metaM xolest2 hs e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:17002
name: cholesterol ester

metaR FAOXC164C165x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR FAOXC164GC163m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM gam6p c
is: SBO:0000247
name: D-Glucosamine 6-phosphate
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: CHEBI:12962
is: HMDB01254
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM ditp n
type: Species
initial amount: NaN
constant: false
name: dITP(4-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
is: SBO:0000247
is: HMDB03537
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110035#_45ed1c45_2188_4c1c_a4e6_d21f10a4e393
name: GGT5
has only substance units: false
is: SBO:0000252
is: P36269
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2687
type: Species
initial concentration: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM pheacgln c
initial amount: NaN
type: Species
is: HMDB06344
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247

metaR AG13T6g
kinetic law: MODEL1310110035#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false

metaR DNDPt40m
reversible: false
product: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110035#
name: dUTP transport via dADP antiport
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_19d2cb3d_ab79_4ebe_a516_d5d882754f04
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q96EK6
is encoded by: hsa:64841
constant: false
boundary condition: true
name: GNPNAT1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_ef130231_0117_4725_85b5_7b39d06d79c9
name: GALNT4
is encoded by: hsa:8693
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: Q8N4A0
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110035#_0d9c4704_b9e2_4d0e_b961_1e80ec73059d
is: SBO:0000252
type: Species
is encoded by: hsa:4882
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NPR2
constant: false
is: P20594
has only substance units: false

metaM HC02204 e
is: CHEBI:27624
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
name: prostaglandin-b1
has only substance units: false
type: Species

metaR EHGLAT2m
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
is: SBO:0000176
reactant: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
kinetic law: MODEL1310110035#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaM gchola e
initial amount: NaN
is: SBO:0000247
type: Species
name: glycocholate
initial concentration: 1.0
is: HMDB00138
constant: false
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_02f32fb6_38e3_4988_b9b4_ca2149a9f6be
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2645
type: Species
name: GCK
is: Q53Y25
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM ksi pre25 g
boundary condition: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
has only substance units: false
initial amount: NaN
constant: false
is: C00130
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 25
is: SBO:0000247
type: Species

metaR NTD7
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110035#
is: SBO:0000176
reversible: false
name: 5'-nucleotidase (AMP)
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR GUAt
reactant: MODEL1310110035#
type: Reaction
name: Guanine transport
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_7fec3a69_b0d2_436a_86b1_28b7006ee378
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:55191
has only substance units: false
boundary condition: true
name: NADSYN1
initial amount: NaN
is: Q6IA69

metaM tetpent3 e
initial amount: NaN
constant: false
is: HMDB06323
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: tetracosapentaenoic acid, n-3
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR GK1
reversible: true
name: guanylate kinase (GMP:ATP)
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaR SACCD4m
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.8
is: SBO:0000176
fast: false
product: MODEL1310110035#
reversible: false
is described by: ECO:0000269
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
modifier: MODEL1310110035#

metaM acglcgalgbside hs g
name: GlcNAc-Gal globoside
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:26174
constant: false
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0

metaR G14T4g
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110035#

metaM ksii core2 pre10 g
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C81H130N6O64S2X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110035#_eb5fcc1a_6468_4d44_b482_d6f354ecb0b0
has only substance units: false
boundary condition: true
is encoded by: hsa:114805
is: Q8IUC8
initial concentration: NaN
constant: false
name: GALNT13
initial amount: NaN
type: Species
is: SBO:0000252

metaM CE5132 c
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110035#_aaeca673_41a7_4474_a78a_1614415192cb
has only substance units: false
is encoded by: hsa:4833
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: NME4
boundary condition: true
is: O00746
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_a9d7b2d7_e578_482b_9fa6_31c259fc54c9
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC26A1
is encoded by: hsa:10861

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
fast: false

metaM HC02204 c
is: CHEBI:27624
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
has only substance units: false
constant: false
name: prostaglandin-b1
initial concentration: 1.0
type: Species

metaR CERT1gt
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
modifier: MODEL1310110035#
name: ceramide transport protein
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_65eddd13_e84a_421d_a53d_f18737c66e03
is: P24752
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ACAT1
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:38
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_035c21f6_7d25_4c4f_baeb_328a5d73a331
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:26289
is: SBO:0000252
name: AK5
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_d93f16d1_642f_484d_be0d_ca4f66ca211c
is: Q8TD20
is: SBO:0000252
constant: false
name: SLC2A12
is encoded by: hsa:154091
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaM taur x
is: CHEBI:15891
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00251
initial amount: NaN
name: taurine
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245

metaR NTD1
type: Reaction
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
name: 5'-nucleotidase (dUMP)
reversible: false
is: SBO:0000176
modifier: MODEL1310110035#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110035#

metaR GALACGLCGALGBSIDEte
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110035#
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
name: galacglcgalgbside hs transport

metaM gal1p c
has only substance units: false
is: SBO:0000247
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: HMDB00645
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58336
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446

http://identifiers.org/biomodels.db/MODEL1310110035#_3312d38e_0f16_47a3_9cce_113425316168
is encoded by: hsa:8883
type: Species
has only substance units: false
is: A8MU28
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NAE1

metaR FAOXC61C4x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR r2408
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: false

metaR GLNALANaEx
type: Reaction
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110035#
product: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false

metaR RE2973C
is: SBO:0000176
fast: false
name: RE2973
reactant: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.1.137
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000

metaR RE1523M
kinetic law: MODEL1310110035#
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110035#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1523
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_4c144a24_a398_4903_b7aa_31f5b3d28bbd
is: P11926
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4953
initial concentration: NaN
name: ODC1
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_bf30411b_aa32_479a_bd59_01aa600ec61a
is encoded by: hsa:51
is: B4DK61
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACOX1
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_f960229b_fb20_4034_a9df_be1244e26c88
initial concentration: NaN
is encoded by: hsa:54344
initial amount: NaN
type: Species
boundary condition: true
is: Q86TM7
is: SBO:0000252
has only substance units: false
name: DPM3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_9233c44f_433b_451f_8c04_f40c3e3232ed
is: D3DX95
constant: false
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_2c17bb91_4462_4672_b811_c9d811be31e2
has only substance units: false
is encoded by: hsa:6561
is: Q9BZW2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: SLC13A1

http://identifiers.org/biomodels.db/MODEL1310110035#_e5378702_f698_47c0_9127_98dc218b2753
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALPL
is: B7Z4Y6
type: Species
constant: false
is encoded by: hsa:249

metaR DHEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
name: Dehydroepiandrosterone transport
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
type: Reaction
reactant: MODEL1310110035#
is: SBO:0000185
is described by: ECO:0000269
fast: false

metaM stcoa x
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57394
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_2ef3c3c7_85c2_4abc_9879_a711121b4500
initial amount: NaN
is encoded by: hsa:2821
initial concentration: NaN
name: GPI
is: P06744
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR PYNP2r
type: Reaction
reactant: MODEL1310110035#
name: pyrimidine-nucleoside phosphorylase (uracil)
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
kinetic law: MODEL1310110035#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110035#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110035#

metaM odecoa r
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
is: CHEBI:57387
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: oleoyl-CoA(4-)
constant: false
is: HMDB01322

metaM ctdecdcoa m
is: C08260
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00672
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
name: cis2trans4decadienoylcoa
constant: false
type: Species

metaR NTD3
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110035#
name: 5'-nucleotidase (dCMP)
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110035#
reversible: false
fast: false
modifier: MODEL1310110035#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
is: CHEBI:26174
is: SBO:0000247
boundary condition: false
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
has only substance units: false
initial concentration: 1.0

metaM nadph c
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00221
is: SBO:0000247
type: Species
is: C00005
constant: false

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
is: HMDB01487
is: CHEBI:57945
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110035#_2ff34c06_91ab_4811_819c_4231fd1213f9
is encoded by: hsa:2954
boundary condition: true
has only substance units: false
name: GSTZ1
is: SBO:0000252
is: A6NED0
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3d8f0760_9bfc_4b71_ad21_3ebe2ab93924
is encoded by: hsa:115019
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: SLC26A9
type: Species
is: B3KXK1

metaR PEt
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110035#
product: MODEL1310110035#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
reversible: true
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_54197038_ebbb_48f1_9527_6e83590b22c4
is: Q7KZA3
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: FECH
initial concentration: NaN
is encoded by: hsa:2235

metaM ksi pre36 g
type: Species
is: CHEBI:28067
constant: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 36
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM dhdascb c
is: CHEBI:58070
boundary condition: false
initial amount: NaN
constant: false
name: dehydroascorbide(1-)
type: Species
has only substance units: false
is: HMDB01264
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110035#_a2b9178d_a0c9_42ed_8ca5_d9d4e27868b8
is encoded by: hsa:60490
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: PPCDC
constant: false
initial concentration: NaN
is: Q96CD2

metaR r1932
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000000
product: MODEL1310110035#

metaR GALACGLCGALGBSIDEtg
type: Reaction
name: galacglcgalgbside hs intracellular transport
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
fast: false

metaR r1487
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110035#
is: SBO:0000176
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
product: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR q10tm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
name: transport of ubiquinone into mitochondria
is described by: ECO:0000134

metaR SERGLYexR
reactant: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange
is described by: ECO:0000304
type: Reaction
reversible: true
kinetic law: MODEL1310110035#
fast: false

metaM pheacgln e
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
is: HMDB06344
is: CHEBI:58310
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species

metaM hexdicoa r
is: SBO:0000247
constant: false
is: C08260
is: HMDB00672
type: Species
name: hexadecanedioylcoa
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0

metaR ACGALtly
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
name: N-acetyl-galactosamine lysosomal efflux

metaR FAOXC102C101m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM acgbgbside hs c
initial concentration: 1.0
type: Species
is: CHEBI:17411
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00215
boundary condition: false
name: beta GalNAc globoside
constant: false

metaM ksii core4 pre5 g
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C69H112N6O48X CHARGE: -1
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
is: C00130

metaM Rtotal2coa c
boundary condition: false
name: R total 2 coenzyme A
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01564
is: CHEBI:57876
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR FAOXC226C227m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR C3STDH1Pr
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
fast: false
kinetic law: MODEL1310110035#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
is: SBO:0000176
modifier: MODEL1310110035#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reactant: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_99fff8ff_a617_48e7_ac6c_cc0d3c86427b
is: E7EPT3
is encoded by: hsa:501
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: ALDH7A1
type: Species
has only substance units: false

metaR r0407
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
reversible: true
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reactant: MODEL1310110035#

metaR r1636
is: SBO:0000185
reactant: MODEL1310110035#
modifier: MODEL1310110035#
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_4e1dd2b9_9e62_4213_bbff_5778ad9c72e6
boundary condition: true
name: GYG1:GYS2
has part: D3DNH0
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2992
is: SBO:0000297
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_36a5ba49_fb60_48b1_bc59_7ce31afc95e1
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC8A3
is: SBO:0000252
constant: false
is encoded by: hsa:6547
initial amount: NaN
type: Species

metaM dhcholestancoa x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial concentration: 1.0
constant: false
is: HMDB02159
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:15494

http://identifiers.org/biomodels.db/MODEL1310110035#_55a69bd2_4f3a_47e6_a63b_0ef66b7b8abc
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8671
initial amount: NaN
type: Species
has only substance units: false
name: SLC4A4
is: A5JJ20

metaM ru5p D r
is: HMDB00618
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: D-ribulose 5-phosphate(2-)

metaR r1088
name: Active transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110035#_ac198933_6519_410e_a116_703cb4c62481
name: PDE9A
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_7b999ee6_f77f_4ae9_b8f4_54d51136faa0
type: Species
is: P25325
is encoded by: hsa:4357
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: MPST
initial concentration: NaN
has only substance units: false
constant: false

metaR r0817
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110035#
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2

metaM cholate c
is: CHEBI:29747
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00619
constant: false
name: Cholate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_070c8f53_398f_4a49_b2df_8c46fa00e3bb
is: SBO:0000297
constant: false
type: Species
is encoded by: hsa:51227
is encoded by: hsa:5277
has only substance units: false
is encoded by: hsa:5279
initial concentration: NaN
has part: P57054
boundary condition: true
has part: B2RAU6
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091

http://identifiers.org/biomodels.db/MODEL1310110035#_5f09d66a_ab94_45c1_bf65_c17f75ae695a
initial concentration: NaN
boundary condition: true
type: Species
name: _AA614647_1_c
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AA614647

metaM fad c
initial concentration: 1.0
initial amount: NaN
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
type: Species
is: C00016
boundary condition: false
constant: false
is: CHEBI:16238
has only substance units: false

metaR r1637
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000185
product: MODEL1310110035#

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR 3HBCOAHLm
kinetic law: MODEL1310110035#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
reversible: false
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_c879b524_3c02_455f_93ce_01caa3edc5aa
is encoded by: hsa:8818
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:54344
initial concentration: NaN
is: SBO:0000297
has part: Q9P2X0
initial amount: NaN
name: DPM3:DPM1:DPM2

metaM leugly e
has only substance units: false
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: Leucylglycine
notes: FORMULA: C8H16N2O3 CHARGE: 0

metaR NMNATr
type: Reaction
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000176
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.7.1
reversible: true
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269

metaM 3aib e
initial amount: NaN
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
type: Species
is: HMDB02166
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaM dmnoncrn c
notes: FORMULA: C18H37NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: HMDB06202

metaR G14T7g
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
reactant: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
modifier: MODEL1310110035#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM so3 c
is: HMDB00240
is: SBO:0000247
is: C00094
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: Sulfite
type: Species
is: CHEBI:17137
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaR r0688
product: MODEL1310110035#
modifier: MODEL1310110035#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
kinetic law: MODEL1310110035#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM acnacngalgbside hs e
is: CHEBI:3338
boundary condition: false
is: C00036
has only substance units: false
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
initial amount: NaN
is: HMDB00223
initial concentration: 1.0
name: disialyl galactosylgloboside
constant: false

metaR B3GNT39g
kinetic law: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM C02528 c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
is: CHEBI:36234
initial amount: NaN
is: HMDB00518
name: chenodeoxycholate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110035#_db659ba9_44e7_4611_9d4a_72f4b9bcff8b
is encoded by: hsa:51227
initial amount: NaN
name: PIGP
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P57054
constant: false
is: SBO:0000252

metaR r1634
fast: false
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110035#

metaR BALAtmr
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
kinetic law: MODEL1310110035#

metaM lcts g
initial concentration: 1.0
name: lactose
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: SBO:0000247
is: CHEBI:17716
type: Species
has only substance units: false
is: HMDB00186
initial amount: NaN
constant: false
boundary condition: false

metaM 1p3h5c m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: CHEBI:6151
is: HMDB01369
constant: false
initial concentration: 1.0

metaR DGULND
is: SBO:0000176
kinetic law: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110035#
reactant: MODEL1310110035#
reversible: true
name: dehydro-L-gulonate decarboxylase
type: Reaction
fast: false

metaM n2m2masn g
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C50H83N4O35X CHARGE: 0
constant: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
is: C11530

metaR GLYCLTtp
name: glycolate transport into peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110035#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_1469f21e_261d_432a_bc66_0dab99d97ff2
is: O95395
constant: false
initial amount: NaN
is encoded by: hsa:9245
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: GCNT3

http://identifiers.org/biomodels.db/MODEL1310110035#_93524244_98e3_417a_9f33_e0a070a0a9ea
is: SBO:0000252
is encoded by: hsa:276
is: Q6NSB3
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: AMY1A
boundary condition: true
initial amount: NaN

metaR r2090
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
reversible: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is: SBO:0000176

metaR r0819
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110035#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110035#
reversible: true
product: MODEL1310110035#

metaM cholate e
is: CHEBI:29747
name: Cholate
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
has only substance units: false
is: HMDB00619
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_71f4680c_18e1_4a75_8998_5e167f8b49bd
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84105
boundary condition: true
has only substance units: false
is: Q9H0N5
constant: false
type: Species
name: PCBD2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110035#_e626896c_0c92_413c_a9ed_af3b160c73b5
constant: false
initial amount: NaN
is encoded by: hsa:6519
boundary condition: true
name: SLC3A1
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q07837

metaM leugly c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97364
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial concentration: 1.0
name: Leucylglycine
boundary condition: false
constant: false

metaM dgmp c
is: CHEBI:57673
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01044
constant: false
name: dGMP
boundary condition: false
is: C00362
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial concentration: 1.0

metaR r1635
modifier: MODEL1310110035#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
type: Reaction
product: MODEL1310110035#
is: SBO:0000185
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#

metaM 3aib c
initial amount: NaN
name: (S)-3-aminoisobutyric acid
has only substance units: false
is: CHEBI:33094
type: Species
boundary condition: false
is: HMDB02166
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
constant: false

metaR CAATPS
fast: false
product: MODEL1310110035#
is: SBO:0000185
modifier: MODEL1310110035#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.8
kinetic law: MODEL1310110035#
reversible: false
name: Ca ATPase
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is described by: ECO:0000269

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
modifier: MODEL1310110035#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110035#
reactant: MODEL1310110035#
fast: false
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000

metaR GLDBRAN
product: MODEL1310110035#
name: glycogen debranching enzyme
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.25
is: SBO:0000176
reactant: MODEL1310110035#
type: Reaction
reversible: false
kinetic law: MODEL1310110035#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (178.4) or (178.5) or (178.1) or (178.3) or (178.2) or (178.6) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.33 Confidence Level: 4 AUTHORS: PMID:1374391 NOTES:lumped reaction, combination of 4-alpha-D-glucanotransferase (2.4.1.25) and amylo-alpha-1,6-glucosidase (3.2.1.33) NCD

metaR FAOXC2242046x
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
type: Reaction

metaM ksi deg26 l
has only substance units: false
initial concentration: 1.0
is: CHEBI:58343
constant: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 26
is: HMDB00061
boundary condition: false

metaR SUCOASm
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
reactant: MODEL1310110035#
name: Succinate--CoA ligase (ADP-forming)
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
modifier: MODEL1310110035#
is: SBO:0000176
fast: false
product: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM ksi deg39 l
name: keratan sulfate I, degradation product 39
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936

metaM acnacngalgbside hs g
is: HMDB00223
initial amount: NaN
constant: false
is: CHEBI:3338
name: disialyl galactosylgloboside
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR CYSTSERex
name: L-cystine/glycine exchanger (cystine in)
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
is described by: ECO:0000269
fast: false
modifier: MODEL1310110035#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction

metaR r0818
is: SBO:0000185
fast: false
name: Transport reaction
kinetic law: MODEL1310110035#
reversible: false
reactant: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r2091
is: SBO:0000185
reactant: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110035#

metaM ptdcacoa m
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06499
name: pentadecanoyl Coenzyme A
type: Species

metaR DGNSKm
is described by: ECO:0000269
name: deoxyguanosine kinase
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
type: Reaction
product: MODEL1310110035#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
reversible: false
reactant: MODEL1310110035#

metaR ALACYSNaEx
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110035#
reversible: false
modifier: MODEL1310110035#
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is described by: ECO:0000269
type: Reaction

metaM c14dccoa x
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: SBO:0000247
type: Species
is: HMDB02288
initial concentration: 1.0
has only substance units: false
name: tetradecanedioylcoa
boundary condition: false
initial amount: NaN
constant: false

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is described by: ECO:0000000
kinetic law: MODEL1310110035#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110035#
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110035#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110035#_4bbdb7ff_6acc_4f74_a9ec_16f879297de0
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51205
is: Q9NPH0
name: ACP6
initial amount: NaN
has only substance units: false
constant: false

metaR r2092
is described by: ECO:0000000
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
reversible: true
is: SBO:0000185
reactant: MODEL1310110035#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
product: MODEL1310110035#
type: Reaction
fast: false
kinetic law: MODEL1310110035#
is described by: ECO:0000269
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110035#

metaR GLYt7 211 r
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
is described by: ECO:0000269
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110035#

metaR XYLt
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
is: SBO:0000185
kinetic law: MODEL1310110035#
reversible: true
type: Reaction
modifier: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#

metaM hexde7coa x
name: 7-hexadecenoylcoa
is: HMDB02288
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4

metaM glygn5 e
notes: FORMULA: C12H21O11X CHARGE: 0
is: CHEBI:17754
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00131
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110035#_01c318a7_5334_4464_9e08_5c48bc51899c
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:H77542
has only substance units: false
name: _H77542_1_r
boundary condition: true

metaR ADSS
modifier: MODEL1310110035#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110035#
fast: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
type: Reaction
reactant: MODEL1310110035#
product: MODEL1310110035#
name: adenylosuccinate synthase
is version of: http://identifiers.org/ec-code/6.3.4.4

metaM 3dodtricoa x
initial amount: NaN
constant: false
is: C05279
is: HMDB11123
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
name: 3,6,9-dodecatrienoylcoa

metaM xyl D l
initial concentration: 1.0
constant: false
is: CHEBI:15936
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
is: SBO:0000247
type: Species
name: aldehydo-D-xylose
boundary condition: false

metaM dgmp e
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01044
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)
is: CHEBI:57673
boundary condition: false
is: SBO:0000247
type: Species

metaR PIPLCn
is described by: ECO:0000000
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false
name: phosphatidylinositol phospholipase C, nucleus
fast: false
is: SBO:0000176
product: MODEL1310110035#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
modifier: MODEL1310110035#

metaR r2093
modifier: MODEL1310110035#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110035#

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r1790
modifier: MODEL1310110035#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#

metaR r0683
product: MODEL1310110035#
fast: false
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110035#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110035#
is: SBO:0000176
is described by: ECO:0000000

metaM gpi sig r
is: HMDB00224
notes: FORMULA: Y CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: CHEBI:58190
initial concentration: 1.0

metaM dhcholestancoa r
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: HMDB02159
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: CHEBI:15494
has only substance units: false
initial concentration: 1.0

metaM hs deg21 l
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false

metaR r1638
product: MODEL1310110035#
is described by: ECO:0000000
modifier: MODEL1310110035#
fast: false
reactant: MODEL1310110035#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_86c647bc_53ce_4b37_85b0_f5e03f106371
has only substance units: false
type: Species
name: PLA2G2A
boundary condition: true
is: P14555
is encoded by: hsa:5320
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r2094
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
reversible: true
fast: false
product: MODEL1310110035#
modifier: MODEL1310110035#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110035#

metaM strch2 e
type: Species
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial amount: NaN
is: CHEBI:4167
notes: FORMULA: C18H32O16 CHARGE: 0
boundary condition: false
is: HMDB00122
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaR RE3624M
modifier: MODEL1310110035#
is described by: ECO:0000000
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110035#
name: RE3624
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110035#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110035#_c24fe954_b7d8_4a2d_aebf_3b0a4bb6dd2a
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: _AI480132_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI480132
initial concentration: NaN

metaR RE2987X
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
product: MODEL1310110035#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110035#
name: RE2987
is described by: ECO:0000000
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110035#_51b87c1e_a76f_4bcc_b8c6_22610f8d1803
is encoded by: hsa:2982
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2974
initial concentration: NaN
type: Species
name: GUCY1B2:GUCY1A3
has only substance units: false
is: SBO:0000297
has part: D6RDW3

metaR FAOXC9C7m
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaR HIStN1
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
reversible: true
product: MODEL1310110035#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110035#
name: Histidine transport (Na, H coupled)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110035#_ca44b2f7_00ef_41d5_b682_1e501cdb2349
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: QPRT
constant: false
is encoded by: hsa:23475
initial concentration: NaN
is: Q15274

metaR r1639
fast: false
reactant: MODEL1310110035#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110035#
type: Reaction
kinetic law: MODEL1310110035#
product: MODEL1310110035#

metaM fad e
boundary condition: false
has only substance units: false
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: Flavin adenine dinucleotide oxidized
is: C00016
is: CHEBI:16238
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_01eb3a34_1201_4264_af64_9b83314d093b
name: ADSS
is encoded by: hsa:159
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: P30520
boundary condition: true
type: Species

metaR r2095
modifier: MODEL1310110035#
reactant: MODEL1310110035#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110035#
fast: false
product: MODEL1310110035#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
is described by: ECO:0000000
reversible: true
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
kinetic law: MODEL1310110035#
is: SBO:0000176
reactant: MODEL1310110035#
product: MODEL1310110035#
modifier: MODEL1310110035#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110035#_9cdf77c5_4ac5_4535_ac15_5f1b6daab43e
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: P31040
is encoded by: hsa:6389
name: SDHA
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110035#_a503f946_e87e_426d_821e_1010d25520dd
is: SBO:0000252
is encoded by: hsa:5151
has only substance units: false
name: PDE8A
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM acnacngalgbside hs c
has only substance units: false
is: C00036
constant: false
is: CHEBI:3338
is: SBO:0000247
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
initial amount: NaN
is: HMDB00223
boundary condition: false
type: Species
name: disialyl galactosylgloboside

metaM pe hs m
initial amount: NaN
has only substance units: false
name: phosphatidylethanolamine
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
constant: false

metaR CYTK2n
is: SBO:0000176
reactant: MODEL1310110035#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110035#
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110035#_ef7b927a_c6ef_4941_a86f_d15f6cc49943
initial concentration: NaN
is encoded by: hsa:1544
type: Species
name: CYP1A2
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P05177
initial amount: NaN
constant: false

metaM dolp L c
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57683
type: Species
initial amount: NaN
name: dolichyl phosphate(2-)

metaR PUNP4
is described by: ECO:0000269
fast: false
product: MODEL1310110035#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110035#
type: Reaction
modifier: MODEL1310110035#
reversible: true
reactant: MODEL1310110035#

metaR GLGNS1
reactant: MODEL1310110035#
product: MODEL1310110035#
reversible: false
name: glycogen synthase (ggn -> glygn1)
fast: false
is described by: ECO:0000000
modifier: MODEL1310110035#
is version of: http://identifiers.org/ec-code/2.4.1.11
is version of: http://identifiers.org/ec-code/2.4.1.186
is: SBO:0000176
notes: GENE_ASSOCIATION: (8908.1) and (2997.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2998.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.11 Confidence Level: 2 AUTHORS: PMID:15238248 NOTES:NCD
kinetic law: MODEL1310110035#
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR SO4tl
is described by: ECO:0000269
fast: false
name: Sulfate transport (lysosome)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110035#
reversible: true
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
product: MODEL1310110035#

metaM HC01409 m
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:27540

metaM glcur e
constant: false
name: D-glucuronate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
type: Species
is: HMDB00127

metaR r2096
fast: false
reversible: true
reactant: MODEL1310110035#
kinetic law: MODEL1310110035#
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110035#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PROD2m
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
name: Proline dehydrogenase (m)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.8
modifier: MODEL1310110035#
is described by: ECO:0000254
type: Reaction
fast: false
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
reversible: false
product: MODEL1310110035#

metaM 1p3h5c c
is: HMDB01369
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
boundary condition: false
is: CHEBI:6151
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_3750b747_ccb4_436f_9972_9cddac9a40c7
is: P30838
is encoded by: hsa:218
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: ALDH3A1
boundary condition: true
has only substance units: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110035#
reactant: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_904c3e86_02e4_4f4a_873e_999911d7d706
name: INPP5E
is: SBO:0000252
is: Q9NRR6
is encoded by: hsa:56623
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR FAOXC10C8x
kinetic law: MODEL1310110035#
product: MODEL1310110035#
reactant: MODEL1310110035#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110035#_c017c443_2fa3_4cfc_b198_b568d8b5df6a
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P22304
constant: false
name: IDS
is: SBO:0000252
type: Species
is encoded by: hsa:3423

metaR 5AOPtm
product: MODEL1310110035#
reversible: true
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
reactant: MODEL1310110035#
name: 5-Aminolevulinate mitochondrial transport
fast: false
is: SBO:0000185

metaR PUNP5
name: purine-nucleoside phosphorylase (Inosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110035#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110035#
reversible: true
product: MODEL1310110035#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110035#

metaR 34HPPte
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
type: Reaction
product: MODEL1310110035#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110035#
fast: false
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110035#

http://identifiers.org/biomodels.db/MODEL1310110035#_02ae76b8_b015_45a8_a801_091ac14e4cc3
constant: false
is: SBO:0000252
type: Species
name: COASY
is: Q13057
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80347
has only substance units: false
boundary condition: true

metaR LSTO1r
is: SBO:0000176
product: MODEL1310110035#
reversible: false
fast: false
reactant: MODEL1310110035#
is described by: ECO:0000269
name: Lathosterol oxidase
is version of: http://identifiers.org/ec-code/1.14.21.6
type: Reaction
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
modifier: MODEL1310110035#
kinetic law: MODEL1310110035#

metaM fadh2 c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01197
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
is: CHEBI:58307
name: FADH2(2-)
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110035#_aabee97b_0425_4f1d_ac84_3c9f63597bda
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:79053
name: ALG8
initial amount: NaN