metaM mi3p D c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 1D-myo-inositol 3-phosphate(2-)
initial amount: NaN
is: HMDB06814
constant: false
has only substance units: false
type: Species
is: CHEBI:58401

metaM xol7ah3 c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB12455
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: CHEBI:28540
type: Species
has only substance units: false

metaM pglyc hs e
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
is: CHEBI:60523
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: phosphatidylglycerol(1-)

metaM cs c deg5 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false
is: CHEBI:15936
type: Species
initial amount: NaN

metaR PROt2r
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: L-proline reversible transport via proton symport

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR r1585
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_58ca9f98_4bf8_4b3c_8643_a78e0db98c41
name: _BC005314_1_x
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:BC005314

metaM h2o x
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: H2O
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
is: C00001
is: SBO:0000247
is: HMDB02111
has only substance units: false

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: carnitine transferase
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110034#_0761679d_6e40_4178_aac4_d3b59599d60e
constant: false
name: CTPS2
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9NRF8
has only substance units: false
is encoded by: hsa:56474
initial concentration: NaN
type: Species

metaR r0926
type: Reaction
reversible: false
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
name: Postulated transport reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

metaM 6a2ohxnt x
is: HMDB12151
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
boundary condition: false
name: 6-amino-2-oxohexanoic acid
initial concentration: 1.0
is: CHEBI:17534
type: Species
has only substance units: false
constant: false

metaM cs e deg7 l
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
notes: FORMULA: C23H35O27S2 CHARGE: -3
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:15936

http://identifiers.org/biomodels.db/MODEL1310110034#_87fdd44e_8b62_4675_8e07_6bd824b61deb
is: P13716
initial concentration: NaN
constant: false
name: ALAD
initial amount: NaN
type: Species
is encoded by: hsa:210
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r1586
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
fast: false

metaM hdca l
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00220
type: Species
boundary condition: false
has only substance units: false
constant: false
name: palmitate

http://identifiers.org/biomodels.db/MODEL1310110034#_6c445d8b_6fb8_4711_8cae_0a1d31157813
name: ADH1B
type: Species
is: P00325
is encoded by: hsa:125
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM pglyc hs c
initial concentration: 1.0
is: CHEBI:60523
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: phosphatidylglycerol(1-)
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial amount: NaN

metaM prostgh2 r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01381
is: CHEBI:57405
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110034#_db7aa376_99ad_40e2_96ea_30189a8977dc
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:57127
name: RHBG
initial concentration: NaN
is: Q9H310
boundary condition: true
has only substance units: false

metaR GTMLTe
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110034#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110034#
product: MODEL1310110034#
name: g-glutamyltransferase (e)
fast: false

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ed272b48_dff6_435b_b439_6535f4459712
initial concentration: NaN
initial amount: NaN
is: A8K092
boundary condition: true
constant: false
is encoded by: hsa:498
is: SBO:0000252
has only substance units: false
type: Species
name: ATP5A1

metaM dag hs r
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:18035
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_1907dca8_17ff_4256_823f_4ac7220415a6
is: Q4J699
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:491
name: ATP2B2
initial concentration: NaN

metaM lnlnca r
is: SBO:0000247
name: alpha-linolenate
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01388
is: CHEBI:32387
constant: false
boundary condition: false

metaM malthp e
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: C01936
boundary condition: false
name: maltoheptaose
is: http://identifiers.org/pubchem.compound/5041

metaR r0819
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
product: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185

metaR EX ddece1crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaM HC00250 c
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
is: CHEBI:29919
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: hydrosulfide
is: SBO:0000247

metaR r2526
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_518041c6_522d_4660_b6ea_ddc8bec74e0f
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:501
is: E7EPT3
name: ALDH7A1

metaR RE1901R
name: RE1901
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
is described by: ECO:0000000

metaR r1584
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110034#

metaR r0818
reactant: MODEL1310110034#
fast: false
name: Transport reaction
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_645f360a_2bd0_4614_9a57_ed2061decd12
constant: false
name: DHCR24
is: Q15392
initial amount: NaN
has only substance units: false
is encoded by: hsa:1718
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR r2525
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185

metaR LNLCCPT1
reversible: false
fast: false
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110034#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110034#

metaR GDPtg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110034#
name: GDP intracellular transport
product: MODEL1310110034#

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110034#
type: Reaction

metaM lnlnca l
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
has only substance units: false
name: alpha-linolenate
type: Species
is: CHEBI:32387
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR CSNAT2x
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is described by: ECO:0000269
reversible: true
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.137

metaM tsul m
is: SBO:0000247
name: thiosulfate(2-)
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false
initial concentration: 1.0
is: HMDB00257
type: Species

metaM HC00250 e
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
initial concentration: 1.0
is: CHEBI:29919
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_dc154381_8957_4697_adb0_44f820a31083
initial amount: NaN
name: PPA2
is: F8WDN9
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27068

metaM pail hs n
initial amount: NaN
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
initial concentration: 1.0
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
has only substance units: false

metaM HC01609 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: UroporphyrinogenI
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
boundary condition: false
constant: false
type: Species
is: CHEBI:28766
has only substance units: false

metaM pheme m
is: C00032
type: Species
is: CHEBI:17627
name: Protoheme
boundary condition: false
is: HMDB03178
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN

metaR r1589
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
fast: false
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000

metaR NACHEX17ly
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110034#
fast: false

metaM coa c
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
type: Species
is: CHEBI:3312
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Coenzyme A
initial concentration: 1.0
is: C00010

metaR NACHEX10ly
reversible: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is described by: ECO:0000000

metaM cholp g
is: CHEBI:295975
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: C00588
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
is: SBO:0000247

metaM cholcoar x
is: HMDB02178
initial amount: NaN
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: CHEBI:58677
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
constant: false

metaM hs deg2 l
is: HMDB01352
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:17180
name: heparan sulfate, degradation product 2
initial concentration: 1.0
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
type: Species
boundary condition: false
constant: false

metaM retinol e
name: retinol
constant: false
is: HMDB00305
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
boundary condition: false
initial amount: NaN
is: CHEBI:50211
type: Species
initial concentration: 1.0
has only substance units: false

metaR ANTHte
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110034#
name: Transport of anthranilate
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaR DCK2n
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110034#
name: Deoxycytidine kinase, nuclear (UTP)
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#

metaM Sfglutth c
constant: false
initial amount: NaN
name: S-formylglutathionate(1-)
is: CHEBI:57688
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: HMDB01550
type: Species

metaM ditp c
boundary condition: false
name: dITP(4-)
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial concentration: 1.0
is: SBO:0000247
is: HMDB03537
constant: false
type: Species
has only substance units: false
is: CHEBI:61382

metaR GUAD
product: MODEL1310110034#
fast: false
is: SBO:0000176
modifier: MODEL1310110034#
name: guanine deaminase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.3
type: Reaction
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
reactant: MODEL1310110034#

metaR r1587
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_85882f18_c748_41a7_9793_f0f82aaed9c8
is: SBO:0000252
is: Q9Y5B8
name: NME7
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:29922
constant: false
boundary condition: true

metaR ALCD21 L
is version of: http://identifiers.org/ec-code/1.1.1.1
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110034#
name: alcohol dehydrogenase (L-1,2-propanediol)
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction

metaR 4NPHte
is: SBO:0000185
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110034#
reactant: MODEL1310110034#
name: xenobiotic transport

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110034#
is: SBO:0000176

metaR FAS80COA L
product: MODEL1310110034#
modifier: MODEL1310110034#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

metaM pyr x
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: C00022
name: pyruvate
has only substance units: false
type: Species
is: HMDB00243

metaM hdca r
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
type: Species
is: CHEBI:7896
initial amount: NaN
boundary condition: false
is: C00249
constant: false
has only substance units: false

metaM retinol c
name: retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
boundary condition: false
is: HMDB00305
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:50211
type: Species
initial amount: NaN

metaR CYTK14n
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_d8651158_e778_4d05_9f9b_17be261957ea
type: Species
is encoded by: hsa:5281
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false
has part: Q6IB04
boundary condition: true
name: PIGF:PIGO
is encoded by: hsa:84720
constant: false

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_5835554c_5f2d_40bf_8a72_e890851cd330
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: ALDOC
is encoded by: hsa:230
constant: false
has only substance units: false
is: P09972

metaR N3Tg
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
fast: false
reversible: false
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000

metaM coa e
name: Coenzyme A
initial concentration: 1.0
is: C00010
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB01423
is: SBO:0000247
is: CHEBI:57287

metaR r1658
modifier: MODEL1310110034#
reversible: true
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
fast: false

metaR r0813
is: SBO:0000185
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110034#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9

http://identifiers.org/biomodels.db/MODEL1310110034#_abbfdae3_0e00_408a_b596_471c4ae04007
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has part: O75947
is encoded by: hsa:515
is encoded by: hsa:10476
constant: false
has part: P18859
is encoded by: hsa:518
has part: P24539
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:522
is: SBO:0000297

metaR SPHS1Pte
kinetic law: MODEL1310110034#
name: sphingosine-1-phosphate transport
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
type: Reaction

metaM s7p c
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57483
name: Sedoheptulose 7-phosphate
is: HMDB01068
boundary condition: false
is: C05382
initial concentration: 1.0
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

metaR r0287
fast: false
modifier: MODEL1310110034#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_8219140c_fb40_424b_ada2_f8b0181cf2c1
is encoded by: hsa:R39999
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: _R39999_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
type: Reaction
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
product: MODEL1310110034#

metaR r1659
product: MODEL1310110034#
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM ditp n
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61382
is: HMDB03537
initial concentration: 1.0
has only substance units: false
name: dITP(4-)
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345

http://identifiers.org/biomodels.db/MODEL1310110034#_c0a095ad_f9db_4a58_ae6f_afc285b17d1f
has only substance units: false
is encoded by: hsa:8140
is: SBO:0000252
name: SLC7A5
initial amount: NaN
type: Species
constant: false
is: Q8IV97
initial concentration: NaN
boundary condition: true

metaR r0812
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
modifier: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1

metaM ksii core2 deg5 l
constant: false
initial amount: NaN
is: HMDB00143
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 5
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110034#_cf29e910_2d8e_4cb1_b9a4_4930e40c622b
is: SBO:0000252
has only substance units: false
is: P04745
is encoded by: hsa:277
boundary condition: true
name: AMY1B
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_63fa77ad_445b_4be8_9fcc_320fb174d92f
name: HMOX2
type: Species
is: P30519
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3163

metaR RE2626C
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
name: RE2626
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction
reactant: MODEL1310110034#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_cdb68091_d690_48c7_8537_b4534ca4b7ad
has only substance units: false
boundary condition: true
is: SBO:0000252
name: EARS2
is encoded by: hsa:124454
is: Q5JPH6
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR r1433
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#

metaR DM dgtp m
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgtp(m)
type: Reaction

metaM gd2 hs g
name: GD2
notes: FORMULA: C60H101N4O33FULLRCO CHARGE: -2
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28648
has only substance units: false
initial concentration: 1.0
type: Species

metaR r0680
reactant: MODEL1310110034#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176
is described by: ECO:0000000
reversible: true

metaM acetol c
boundary condition: false
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06961
has only substance units: false
is: CHEBI:27957

http://identifiers.org/biomodels.db/MODEL1310110034#_530f241d_b59d_401f_ac4d_c33d9a1f943e
is: SBO:0000252
is encoded by: hsa:4758
constant: false
type: Species
initial amount: NaN
name: NEU1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q99519

metaR r1656
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reversible: true
reactant: MODEL1310110034#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CORE6GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110034#_76c616c0_382d_42f0_a0d2_094de13b73da
initial concentration: NaN
name: _R51273_1_c
is encoded by: hsa:R51273
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: prostaglandin F2alpha(1-)
is: HMDB01139
has only substance units: false
is: CHEBI:57404
initial amount: NaN

metaM hmbil c
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: SBO:0000247
has only substance units: false
is: C01024
boundary condition: false
constant: false
type: Species
is: CHEBI:57845
initial concentration: 1.0
is: HMDB01137
name: Hydroxymethylbilane
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_86cbcd33_b472_4931_b014_340b2ec361aa
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:10768
boundary condition: true
name: AHCYL1
initial concentration: NaN
type: Species

metaR r0683
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
fast: false

metaR NP1
kinetic law: MODEL1310110034#
is described by: ECO:0000304
name: nucleotide phosphatase
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r1657
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
fast: false

metaR PEt
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
type: Reaction
product: MODEL1310110034#
reversible: true
name: phosphatidylethanolamine transport
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR RE2659R
reactant: MODEL1310110034#
type: Reaction
reversible: true
name: RE2659
is: SBO:0000176
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110034#
is described by: ECO:0000000

metaM pheme c
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: SBO:0000247
is: HMDB03178
name: Protoheme
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00032
type: Species
initial concentration: 1.0
constant: false

metaR DPCOAK
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: dephospho-CoA kinase
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f54ec2a0_ee1d_41ef_82d0_e2c4df8613ac
type: Species
initial amount: NaN
is: SBO:0000297
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
initial concentration: NaN
boundary condition: true
constant: false

metaR ADEt
is: SBO:0000185
is described by: ECO:0000269
reversible: true
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
name: adenine reversible transport, cytosol

metaR r1431
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: false

metaM pheme e
is: HMDB03178
is: SBO:0000247
is: C00032
initial amount: NaN
is: CHEBI:17627
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false

metaR r1654
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_7b2f2086_1a0b_444e_8fd0_054b5b93578b
boundary condition: true
name: ACSL4
initial amount: NaN
is: Q5JWV8
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2182
has only substance units: false
type: Species

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is described by: ECO:0000000
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:

metaM itacon m
constant: false
is: CHEBI:17240
is: SBO:0000247
is: HMDB02092
boundary condition: false
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_36bdff29_c55a_4770_8ff9_e81ae1a633c3
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5139
type: Species
name: PDE3A
has only substance units: false
is: SBO:0000252
is: Q14432

http://identifiers.org/biomodels.db/MODEL1310110034#_6622efda_f7ef_4057_a893_5ef90aab63ce
name: CYP27A1
is encoded by: hsa:1593
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: Q02318

metaM 44mctr r
type: Species
constant: false
is: CHEBI:17813
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
is: HMDB01023
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_1a96ffb7_968c_47e0_b02c_ab8e241fb365
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NT5C1B
type: Species
is: Q96P26
constant: false
initial concentration: NaN
is encoded by: hsa:93034

metaR r1655
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_e4958f94_2c6a_47c4_a605_9e8ff2757063
is encoded by: hsa:587
initial amount: NaN
name: BCAT2
type: Species
initial concentration: NaN
boundary condition: true
is: O15382
has only substance units: false
is: SBO:0000252
constant: false

metaM HC01522 c
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28508
has only substance units: false
name: Gentisate aldehyde
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

http://identifiers.org/biomodels.db/MODEL1310110034#_675d0fb2_d991_4dd0_8629_d80a8697693d
type: Species
initial concentration: NaN
name: NAGA
boundary condition: true
is: SBO:0000252
is: P17050
constant: false
is encoded by: hsa:4668
has only substance units: false
initial amount: NaN

metaM rib D e
name: D-ribose
type: Species
is: SBO:0000247
is: CHEBI:16988
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM HC00361 c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
boundary condition: false
is: CHEBI:58335
name: sedoheptulose 1,7-bisphosphate(4-)

metaR CSAPASEly
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110034#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaM tsul c
initial amount: NaN
initial concentration: 1.0
is: HMDB00257
has only substance units: false
name: thiosulfate(2-)
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
is: SBO:0000247
boundary condition: false
type: Species

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR r1652
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_cdc0f0d9_19eb_46ab_82e6_1003e6f6a2c0
name: SLC8A2
has only substance units: false
is: Q9UPR5
is encoded by: hsa:6543
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaM xol7ah3 m
is: HMDB12455
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:28540
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaR HDD2COAtx
kinetic law: MODEL1310110034#
name: hdd2coa intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: true
type: Reaction

metaR BTNt2
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
name: Biotin reversible transport via proton symport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_b59cc124_10dd_442a_8c23_26e9beaed223
boundary condition: true
is: P16930
is: SBO:0000252
is encoded by: hsa:2184
has only substance units: false
name: FAH
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM 5hoxindact c
is: CHEBI:50157
name: (5-hydroxyindol-3-yl)acetaldehyde
is: SBO:0000247
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
has only substance units: false
is: HMDB04073
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR FCLTm
fast: false
reactant: MODEL1310110034#
name: Ferrochelatase, mitochondrial
is described by: ECO:0000304
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.99.1.1
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_1da67ea4_0b7f_4e3a_9fa9_25e8ffe9edba
is: SBO:0000252
is encoded by: hsa:10331
constant: false
is: Q9Y2A9
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: B3GNT3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_e1f8b2b1_2d9b_47bf_9468_d97a424761f5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P56937
has only substance units: false
name: HSD17B7
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:51478

http://identifiers.org/biomodels.db/MODEL1310110034#_9997a231_84a8_4bd5_a255_c283e41bbef1
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3422
name: IDI1
is: Q13907

metaR r1653
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR RE2973C
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110034#

metaR r1580
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaM rib D c
name: D-ribose
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
is: HMDB00283
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM eandrstrn r
is: SBO:0000247
name: 16alpha-hydroxydehydroepiandrosterone
constant: false
is: CHEBI:27771
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1 EHMN_ABBREVIATION: C05139
is: HMDB00352
type: Species

metaR r0280
fast: false
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reversible: false
modifier: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000

metaR CHTNASEe
is described by: ECO:0000269
name: chitinase, extracellular
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.14
reversible: false
notes: GENE_ASSOCIATION: (27159.2) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.14 Confidence Level: 4 AUTHORS: PMID:11085997 NOTES:NCD
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#

metaR FE2t
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
fast: false
reversible: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: iron (II) transport
is: SBO:0000185

metaM glu5sa m
has only substance units: false
initial amount: NaN
boundary condition: false
is: C01165
is: SBO:0000247
is: HMDB02104
initial concentration: 1.0
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
constant: false
type: Species

metaM coa x
is: CHEBI:57287
constant: false
has only substance units: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
is: C00010
is: SBO:0000247
name: Coenzyme A
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1651
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM m2emgacpail hs r
type: Species
is: http://identifiers.org/pubchem.compound/3380
is: C00080
initial amount: NaN
has only substance units: false
is: CHEBI:24636
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
boundary condition: false
initial concentration: 1.0

metaR r0688
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is described by: ECO:0000000
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
product: MODEL1310110034#
reversible: true

metaR UDPGALtg
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000269
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185

metaR DMNONCRNt
reactant: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000

metaR CSNAT2m
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM dag hs c
is: CHEBI:18035
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: diglyceride
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110034#_d6ca109b_5afb_4609_99c3_d2e2f2bb3866
constant: false
is: SBO:0000252
name: PCBD1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5092
type: Species
has only substance units: false
is: P61457

metaR r1650
reversible: true
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2097
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110034#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_59f3634e_f2f7_4d54_b41a_5866713c5ba5
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC25A5
has only substance units: false
constant: false
is encoded by: hsa:292
is: Q6NVC0

http://identifiers.org/biomodels.db/MODEL1310110034#_6418eeda_15af_44e3_94c6_3ed12fadd3cf
is: SBO:0000252
is encoded by: hsa:7167
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: Q53HE2
has only substance units: false
name: TPI1

http://identifiers.org/biomodels.db/MODEL1310110034#_f1d9c2f1_2785_4ea5_8100_693ff0d1c459
constant: false
has only substance units: false
name: NDUFA3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4696
boundary condition: true
is: O95167
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_250d976a_bd1e_42ca_9b90_6b33e1b58b2d
name: FUK
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q8N0W3
is encoded by: hsa:197258
initial concentration: NaN

metaR r1018
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110034#
name: Transport reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
is described by: ECO:0000000

metaM hs deg12 l
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
has only substance units: false
is: HMDB01352
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:17180
name: heparan sulfate, degradation product 12

metaR RE0569E
reversible: false
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4017.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
name: RE0569
reactant: MODEL1310110034#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR NAHCO3 HCLt
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110034#
is described by: ECO:0000269
reversible: true
type: Reaction
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#

metaM h2o g
is: HMDB02111
constant: false
initial concentration: 1.0
is: CHEBI:15377
name: water
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110034#
name: L-carnitine reversible transport
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR RE1521M
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
name: RE1521
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR DDECCRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR r0139
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
modifier: MODEL1310110034#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110034#

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM uacgam g
constant: false
boundary condition: false
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaM 2mop c
constant: false
type: Species
is: HMDB01172
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700

metaR r2094
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_fb3b5797_e263_4dd8_9e9c_fe18454aa2f0
is encoded by: hsa:3939
name: LDHA:LDHB
boundary condition: true
is encoded by: hsa:3945
is: SBO:0000297
has only substance units: false
constant: false
initial concentration: NaN
has part: P00338
initial amount: NaN
has part: P07195
type: Species

metaM xol7aone r
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial amount: NaN

metaM paps g
is: HMDB01134
type: Species
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
is: CHEBI:58339
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false

metaR DDCRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR DHFR
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: dihydrofolate reductase
is described by: ECO:0000254
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is: SBO:0000176

metaM hs deg25 l
is: CHEBI:16126
initial amount: NaN
has only substance units: false
constant: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
boundary condition: false
type: Species
notes: FORMULA: C23H37O21 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_89808fbb_952c_4ee1_9ca6_a988ee29a0de
is: P04035
constant: false
initial concentration: NaN
name: HMGCR
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3156
boundary condition: true
has only substance units: false
type: Species

metaR SLDx
modifier: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
name: L-sulfolactate dehydrogenase (NAD+)
type: Reaction
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
is version of: http://identifiers.org/ec-code/1.1.1.37
is: SBO:0000176
is described by: ECO:0000304

metaM 3php c
is: CHEBI:18110
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
initial amount: NaN
constant: false
is: HMDB01024
initial concentration: 1.0
has only substance units: false
name: 3-phosphonatooxypyruvate(3-)

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r2095
kinetic law: MODEL1310110034#
reversible: true
is described by: ECO:0000000
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110034#

metaM 12ppd S c
constant: false
name: (S)-propane-1,2-diol
is: HMDB06213
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
initial amount: NaN
type: Species
is: CHEBI:29002
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM h2o m
is: C00001
is: CHEBI:15377
boundary condition: false
has only substance units: false
name: H2O
is: SBO:0000247
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
constant: false
is: HMDB02111
initial amount: NaN

metaM creat e
is: HMDB00064
name: creatine
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16919

metaM retinal 11 cis c
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152
boundary condition: false
name: 11-cis-retinal
constant: false
is: CHEBI:16066
initial concentration: 1.0

metaR r2092
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
fast: false
kinetic law: MODEL1310110034#

metaR SBTR
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_b7376bd0_c2ad_475e_956e_a7951a2397af
constant: false
type: Species
name: _AI024818_1_c
has only substance units: false
is encoded by: hsa:AI024818
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_e26641d0_f2aa_4401_b735_43e06c2220c2
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:65985
is: Q86V21
has only substance units: false
type: Species
name: AACS
is: SBO:0000252
boundary condition: true

metaR ST8SIA51g
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110034#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_271c868f_1a89_47cc_8bc8_a99c8eace70f
is encoded by: hsa:10165
name: SLC25A13
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9UJS0
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR UDPGLCAter
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110034#

metaR PSERT
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.52
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
name: phosphoserine transaminase
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_a54cd216_49dc_43bd_b5f9_d21a67dbf176
name: _NOS2A_1_e
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:NOS2A
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM h2o l
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
name: water
has only substance units: false
is: HMDB02111
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15377

metaM coa r
is: HMDB01423
initial amount: NaN
is: C00010
is: CHEBI:57287
initial concentration: 1.0
name: Coenzyme A
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR r2093
reactant: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185

metaR r0821
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM c81coa c
boundary condition: false
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
is: HMDB03949
is: C05276
type: Species
initial amount: NaN
name: octenoylcoa
initial concentration: 1.0

metaR SPHS1Ptr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true
name: sphingosine-1-phosphate transport
type: Reaction
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR ABUTt2r
is described by: ECO:0000304
kinetic law: MODEL1310110034#
reversible: true
name: 4-aminobutyrate reversible transport in via proton symport
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is: SBO:0000185

metaM 5pmev c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01343
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)

metaR NDPK4n
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
modifier: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR ALAGLNexR
reversible: true
kinetic law: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-alanine/glutamine reversible exchange
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000304

metaR CYTK4n
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,GTP),nuclear
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110034#

metaM ura c
is: CHEBI:17568
boundary condition: false
is: SBO:0000247
constant: false
is: C00106
name: Uracil
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00300
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

metaR DGAT
product: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.20
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: diacylglycerol acyltransferase
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_11f00d9f_f8d4_4929_a877_34f726996cd3
type: Species
is encoded by: hsa:10935
is: SBO:0000252
name: PRDX3
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: E9PH29
boundary condition: true

metaM creat c
name: creatine
is: CHEBI:16919
is: HMDB00064
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false

metaR r2090
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM dag hs e
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:18035
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
name: diglyceride

metaR PSFLIPm
kinetic law: MODEL1310110034#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
reactant: MODEL1310110034#

metaR r0686
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reversible: true

metaM CE5121 m
constant: false
initial amount: NaN
name: trans-3-decenoyl-CoA
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
is: CHEBI:57449
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_84b92eb9_b544_4d1d_be6b_0cc27412f985
has only substance units: false
boundary condition: true
constant: false
name: SLC2A3
initial concentration: NaN
is encoded by: hsa:6515
is: P11169
initial amount: NaN
is: SBO:0000252
type: Species

metaR SLDt
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
fast: false
kinetic law: MODEL1310110034#
type: Reaction
name: L-sulfolactate transport (cytosol to extracellular)

http://identifiers.org/biomodels.db/MODEL1310110034#_aa859dc5_9856_449a_a7dc_acaa0d443109
is encoded by: hsa:4701
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q6FG42
initial amount: NaN
name: NDUFA7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b164fd96_ba62_473a_810e_3c12c3bfc2b4
type: Species
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:515
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8acabd21_e8c7_45c3_8ff9_302218a1c1e1
initial amount: NaN
name: SDHD
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: O14521
is encoded by: hsa:6392
has only substance units: false
is: SBO:0000252

metaM paps c
type: Species
has only substance units: false
initial amount: NaN
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
constant: false
is: HMDB01134

http://identifiers.org/biomodels.db/MODEL1310110034#_d7753a03_6a19_4073_b2aa_37c08b0177c8
has only substance units: false
has part: A8K092
is encoded by: hsa:513
initial concentration: NaN
is encoded by: hsa:506
is encoded by: hsa:509
constant: false
is encoded by: hsa:514
has part: P36542
has part: P06576
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
has part: P56381
boundary condition: true
has part: P30049
initial amount: NaN
is: SBO:0000297
type: Species

metaM pail45p hs c
has only substance units: false
boundary condition: false
is: CHEBI:28910
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM gtp n
has only substance units: false
name: GTP(4-)
constant: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:37565

metaM fru e
is: SBO:0000247
is: CHEBI:15824
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
initial amount: NaN
is: C00095
is: HMDB00660
constant: false

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PLA2 2e
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
reversible: false
name: phospholipase A2
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4

metaR ACACT5p
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
product: MODEL1310110034#
fast: false

metaR EX c3dc
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_581e97a0_bf7d_4071_bef5_97382621c78c
is: SBO:0000252
is: Q16831
name: UPP1
is encoded by: hsa:7378
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0c48a22f_2218_4a1d_a1ad_d201a1190712
is encoded by: hsa:84720
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: PIGF:PIGO
has only substance units: false
has part: Q07326
has part: Q8TEQ8
is encoded by: hsa:5281
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110034#_693b9c78_23eb_4582_b1ae_10662ed32e1d
boundary condition: true
has only substance units: false
is encoded by: hsa:5091
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: PC
is: P11498

http://identifiers.org/biomodels.db/MODEL1310110034#_3fce5fa3_2f99_48ac_aa83_be93b8ff94d8
is: SBO:0000252
constant: false
is: P52824
boundary condition: true
is encoded by: hsa:1609
initial concentration: NaN
initial amount: NaN
type: Species
name: DGKQ
has only substance units: false

metaM ksi deg27 l
is: HMDB00143
initial concentration: 1.0
constant: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
name: keratan sulfate I, degradation product 27
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:12936
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_664db838_ea4f_473c_8c96_39c549a1c49c
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: P00441
name: SOD1
is encoded by: hsa:6647
initial amount: NaN
boundary condition: true
has only substance units: false

metaM ura e
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
name: uracil
has only substance units: false
initial concentration: 1.0
is: CHEBI:17568
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaM 2mop m
is: HMDB01172
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
type: Species

metaM cholp c
is: SBO:0000247
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: CHEBI:295975
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_01bde329_c161_4df8_bed8_7e6a3dfdfbf9
type: Species
initial concentration: NaN
initial amount: NaN
name: PTGS2
has only substance units: false
constant: false
is encoded by: hsa:5743
is: P35354
is: SBO:0000252
boundary condition: true

metaR ABTArm
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000269
product: MODEL1310110034#

metaM fru c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15824
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
name: D-Fructose
is: C00095
boundary condition: false

metaM coa n
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
name: coenzyme A(4-)
is: CHEBI:57287
has only substance units: false
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110034#_379cb8e7_4ccd_475a_96f3_8d46bbf73dd9
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:28231
is: SBO:0000252
has only substance units: false
is: Q96BD0
name: SLCO4A1
type: Species
constant: false

metaR r1010
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
product: MODEL1310110034#

metaR GUMTCHOLe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR FAS120COA
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
reversible: false
name: fatty-acyl-CoA synthase (n-C12:0CoA)
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_7226d175_c719_4fd3_adca_4a570ba1bcec
constant: false
is: SBO:0000252
boundary condition: true
is: P15121
has only substance units: false
is encoded by: hsa:231
initial concentration: NaN
name: AKR1B1
type: Species
initial amount: NaN

metaR ECOAH1m
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
modifier: MODEL1310110034#
is: SBO:0000176
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110034#_a9fc1c97_8599_4961_a84d_589a9dd9803f
type: Species
is: SBO:0000252
constant: false
name: SKIV2L2
is: Q3MHC9
is encoded by: hsa:23517
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM 4h2oglt m
is: HMDB02070
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
type: Species
is: CHEBI:17742
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_d1120776_0f81_40a4_8576_7e38d97f547b
type: Species
name: ACAA2
is: SBO:0000252
is encoded by: hsa:10449
initial amount: NaN
constant: false
is: P42765
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR RE2972M
name: RE2972
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_fc022511_ce89_4991_bc14_36b0a581a7bb
is encoded by: hsa:123041
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: SLC24A4
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_dac03998_48a1_4d25_9dfb_a7718bbbea26
boundary condition: true
type: Species
is: SBO:0000252
is: O14521
initial concentration: NaN
initial amount: NaN
name: SDHD
constant: false
is encoded by: hsa:6392
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e27497d6_7631_4c3f_aa07_569fbb569ffc
name: ATP10A
initial amount: NaN
has only substance units: false
is encoded by: hsa:57194
constant: false
is: SBO:0000252
boundary condition: true
is: O60312
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_170db927_2412_4e2a_a8df_1a23a67c11fb
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q53H96
constant: false
initial amount: NaN
is encoded by: hsa:65263
has only substance units: false
boundary condition: true
name: PYCRL

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR NACASPAH
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.1.15
fast: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction
name: N-Acetyl-L-aspartate amidohydrolase

metaR EX 34hpp
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR r0796
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110034#
is: SBO:0000176
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
product: MODEL1310110034#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_c14969fb_9d73_4548_b937_2f162391ed41
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3421
boundary condition: true
is: E9PDD5
constant: false
name: IDH3G
type: Species

metaR OCOAT1m
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.3.5
reversible: true
name: 3-oxoacid CoA-transferase

MODEL1310110034
species: metaM hexdicoa c
species: metaM nac c
reaction: metaR GUAD
species: metaM c101coa c
reaction: metaR r1677
reaction: metaR sink c81coa LPAREN c RPAREN
species: metaM pyr e
species: metaM gacpail hs c
species: metaM Lcyst c
reaction: metaR r1594
species: metaM bilirub e
species: metaM leu L c
reaction: metaR EX pe hs LPAREN e RPAREN
species: metaM hs deg2 l
reaction: metaR CSNATer
species: metaM andrstrn c
species: metaM dump c
species: metaM leuktrA4 c
species: metaM 4mzym int1 r
reaction: metaR PETOHMm hs
reaction: metaR EX ivcrn
species: metaM gthrd c
species: metaM nadph r
species: metaM oh1 e
species: metaM ksii core2 deg1 l
reaction: metaR ASPTAm
species: metaM C05280 m
species: metaM Lcystin e
reaction: metaR LEUGLYPEPT1tc
reaction: metaR r0552
reaction: metaR EX HC01609 LPAREN e RPAREN
reaction: metaR URIt
species: metaM sbt D c
reaction: metaR r0822
species: metaM gt1alpha hs g
species: metaM gtp n
reaction: metaR CDPDAGtm
species: metaM amet m
reaction: metaR GALASE8ly
species: metaM glyphe e
species: metaM trp L e
reaction: metaR r0797
species: metaM damp c
reaction: metaR EX orn LPAREN e RPAREN
reaction: metaR PUNP1
species: metaM dadp m
reaction: metaR EX 3ddcrn
species: metaM cl e
reaction: metaR PSERT
reaction: metaR CSPG Etly
species: metaM mi34p c
reaction: metaR SGPL12r
reaction: metaR CO2ter
species: metaM 5adtststerones c
reaction: metaR RTOTALFATPc
reaction: metaR ME1m
species: metaM ppi m
reaction: metaR r2026
reaction: metaR r1302
reaction: metaR COAtm
reaction: metaR r0475
reaction: metaR r1636
reaction: metaR EX pchol hs LPAREN e RPAREN
reaction: metaR r1549
reaction: metaR H2Otn
reaction: metaR EX gp1calpha hs LPAREN e RPAREN
reaction: metaR r1647
reaction: metaR PMANM
species: metaM ksi deg39 l
species: metaM dopasf c
species: metaM decdicrn c
species: metaM glyald c
reaction: metaR r1810
reaction: metaR ASPt6
reaction: metaR MI3PP
reaction: metaR r0021
reaction: metaR r2506
reaction: metaR SMS
reaction: metaR Coqe
reaction: metaR EX ctp LPAREN e RPAREN

metaR r2398
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_5c9ad43d_38d8_4076_84c1_853fabf4ace0
is: SBO:0000252
has only substance units: false
is: O75355
constant: false
boundary condition: true
type: Species
is encoded by: hsa:956
initial amount: NaN
initial concentration: NaN
name: ENTPD3

metaM 7dhf e
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
name: heptaglutamyl folate (DHF)
constant: false
initial amount: NaN
is: HMDB06559
is: SBO:0000247

metaM h2o n
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247
name: water
is: CHEBI:15377
constant: false

metaM thm c
notes: FORMULA: C12H17N4OS CHARGE: 1
is: HMDB00235
boundary condition: false
name: Thiamin
is: CHEBI:0
type: Species
is: C00378
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110034#
reactant: MODEL1310110034#

metaM HC01603 c
is: C00234
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
boundary condition: false
name: 10-Formyltetrahydrofolate
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false

metaM lnlnca c
type: Species
is: HMDB01388
is: CHEBI:32387
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: alpha-linolenate
initial concentration: 1.0

metaR r0797
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
fast: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
product: MODEL1310110034#

metaR FADtru
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: FAD transporter, endoplasmic reticulum
is: SBO:0000185

metaR DNDPt34m
kinetic law: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110034#
reversible: false
name: dGDP transport via dTDP antiport
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110034#_d5c55c57_7303_429d_ace7_aa16015a18b0
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ABAT
is encoded by: hsa:18

http://identifiers.org/biomodels.db/MODEL1310110034#_dc3b8449_6ebf_4cd4_bff7_c6600015233c
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ACSL3
is encoded by: hsa:2181
type: Species
constant: false
is: O95573

metaM lanost r
initial concentration: 1.0
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: HMDB01251
is: CHEBI:16521
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: lanosterol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5ad2656b_4c50_4bcf_ba05_ceeae61ee8f4
is encoded by: hsa:3706
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ITPKA
is: SBO:0000252
has only substance units: false
constant: false
is: P23677

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_280ee6ec_0c0c_4549_b9bd_c45951503093
has only substance units: false
name: ATP5F1
is encoded by: hsa:515
boundary condition: true
is: Q08ET0
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR ITCOALm
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_4487ae32_023c_47b5_9696_461d822dabe3
is: SBO:0000252
boundary condition: true
constant: false
name: _M68895_1_c
initial concentration: NaN
is encoded by: hsa:M68895
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_ad504e25_332a_45af_aab5_59448e374aa4
initial concentration: NaN
name: GBA
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2629
is: B7Z6S9
boundary condition: true
type: Species
initial amount: NaN

metaM camp c
constant: false
is: HMDB00058
is: SBO:0000247
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
initial amount: NaN
is: CHEBI:58165
boundary condition: false
initial concentration: 1.0
name: 3',5'-cyclic AMP(1-)
has only substance units: false
type: Species

metaM glyald m
constant: false
name: D-glyceraldehyde
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17378
is: HMDB01051
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_64016c5b_3dca_4c57_8b88_cf66db759a11
is encoded by: hsa:5305
constant: false
has only substance units: false
is: P48426
name: PIP4K2A
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM ksi deg16 l
type: Species
constant: false
is: HMDB00812
is: SBO:0000247
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
has only substance units: false
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 16
initial concentration: 1.0
is: CHEBI:16953

metaM uacgam c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
is: CHEBI:57705

metaM coa m
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Coenzyme A
is: C00010
constant: false
type: Species
is: CHEBI:57287
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110034#_a06e96a7_3681_4846_8895_428655bda27a
initial amount: NaN
boundary condition: true
is encoded by: hsa:3141
constant: false
is: P50747
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: HLCS

http://identifiers.org/biomodels.db/MODEL1310110034#_4507f837_0121_4565_9587_57c1556b48d9
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6718
initial concentration: NaN
name: AKR1D1
initial amount: NaN
is: P51857
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_7144deb1_9136_4224_a427_1d4f2cfd052c
has only substance units: false
boundary condition: true
is: P07954
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2271
name: FH

metaR r2098
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110034#

metaR NACHEX21ly
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal

metaR PMANM
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.4.2.8
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110034#
name: phosphomannomutase
reversible: true
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_d53a9e0a_4b9a_42b2_8d19_db47fe951125
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6005
boundary condition: true
name: RHAG
initial concentration: NaN
is: Q96E98
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_af72ee40_05e7_467f_a60f_31c9bfa92542
has only substance units: false
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103
boundary condition: true
is: SBO:0000252
is: Q6LEN5
initial amount: NaN
constant: false
type: Species

metaR r2521
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185

metaM lnlnca e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
name: alpha-linolenate
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:32387
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaM xol7aone m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
type: Species
is: CHEBI:17899
initial amount: NaN

metaR DM gpi sig er
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_59392e69_3069_49f6_b2ce_d91b25607f1e
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
name: _AI971036_1_m

metaR r2099
modifier: MODEL1310110034#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_fd57fd4f_0832_4458_9370_e1d810519bc4
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:33
constant: false
boundary condition: true
is: P28330
name: ACADL
is: SBO:0000252

metaM dag hs n
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
type: Species
has only substance units: false
name: diglyceride
is: CHEBI:18035
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR RIBt
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: ribose transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110034#
fast: false

metaM h2o r
constant: false
is: SBO:0000247
is: CHEBI:15377
type: Species
initial concentration: 1.0
name: H2O
is: HMDB02111
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false
has only substance units: false

metaM ksi deg39 l
type: Species
initial amount: NaN
is: HMDB00143
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 39
is: SBO:0000247
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936

metaR 5ADTSTSTERONEte
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: 5 alpha dihydrotesterone transport
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110034#_6d65da85_13d1_4790_8f36_b809fe7c5a58
type: Species
has only substance units: false
constant: false
name: NDUFA3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4696
initial concentration: NaN
is: O95167
boundary condition: true

metaR F1Atg
kinetic law: MODEL1310110034#
name: F1alpha transport (from golgi to lysosome)
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM ficytC m
has only substance units: false
name: Ferricytochrome c
is: CHEBI:15991
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123

metaR r1571
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110034#

metaM hs deg3 l
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
has only substance units: false
name: heparan sulfate, degradation product 3
type: Species
initial amount: NaN
is: CHEBI:16126
boundary condition: false

metaM ksii core2 deg6 l
has only substance units: false
is: HMDB00143
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 6
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
is: CHEBI:12936

metaM leu L c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: L-leucine
is: CHEBI:15603
is: HMDB00687
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species

metaR r0936
kinetic law: MODEL1310110034#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000
name: Transport reaction
product: MODEL1310110034#

metaR Coqe
is: SBO:0000185
kinetic law: MODEL1310110034#
is described by: ECO:0000134
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of q10
reversible: true
fast: false
reactant: MODEL1310110034#

metaR S4TASE1ly
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110034#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_bfadbcad_7215_4d08_99c1_0518bd3097dd
initial concentration: NaN
type: Species
is encoded by: hsa:AI091231
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AI091231_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_cc995b68_cee2_4456_a890_66260d96869f
initial concentration: NaN
type: Species
name: _H77542_1_r
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:H77542

metaR ASPTA
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
name: aspartate transaminase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
type: Reaction

metaR r1573
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR DM ethamp r
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_efa98a87_a6e7_42a6_8173_a416086c997d
has only substance units: false
constant: false
is encoded by: hsa:8528
type: Species
boundary condition: true
name: DDO
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM val L e
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00883
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: L-valine

http://identifiers.org/biomodels.db/MODEL1310110034#_7492907c_8953_47e8_9aae_f2740cb8d121
type: Species
is: P48735
is encoded by: hsa:3418
constant: false
is: SBO:0000252
name: IDH2
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00143
type: Species
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_feb1e8cd_7065_4771_933f_4c9c72b3b5af
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110034#_4d1b0748_2a34_45a0_97ae_f3116fa307e7
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
name: SLC6A2
initial concentration: NaN
initial amount: NaN
is: Q96KH8
is encoded by: hsa:6530

metaM leu L e
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
is: HMDB00687
is: CHEBI:15603
name: L-leucine

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR r1799
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_357b19dc_6a5a_47d9_a931_b6819ec4757d
is: SBO:0000252
is encoded by: hsa:259230
initial amount: NaN
name: SGMS1
has only substance units: false
type: Species
is: D3DWC4
constant: false
initial concentration: NaN
boundary condition: true

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR PYNP2r
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
kinetic law: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
product: MODEL1310110034#
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)

metaR ASPDxt
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
name: D-aspartate transport, peroxisomal
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_4d089647_9881_4d42_a190_9ee5af493dac
has only substance units: false
is encoded by: hsa:2746
initial amount: NaN
is: E9KL48
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: GLUD1

metaR PYDXDH
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
name: pyridoxal dehydrogenase
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02273
constant: false
initial concentration: 1.0
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331

http://identifiers.org/biomodels.db/MODEL1310110034#_18dfaa36_f791_4017_9d30_b5c18f4fb8b5
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AF080579
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AF080579_1_c
type: Species

metaR r0937
name: Transport reaction
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_603215d5_cd4a_494f_9ed0_ed677eab79e2
initial concentration: NaN
is encoded by: hsa:4942
is: P04181
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: OAT
constant: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM gm1 hs g
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
is: SBO:0000247
type: Species
initial amount: NaN
name: ganglioside GM1
boundary condition: false
is: CHEBI:18216

metaR r1575
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
reversible: true

metaR r1648
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_a7daf760_e437_4485_8811_a930ed9d9da7
constant: false
is: O95139
is: SBO:0000252
name: NDUFB6
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4712
initial amount: NaN
boundary condition: true

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR UAG2EMAi
is described by: ECO:0000269
product: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110034#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:

metaR r2518
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_ed9b5344_3d20_4d6c_a75f_285356292d5a
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI972237
boundary condition: true
name: _AI972237_1_c
has only substance units: false

metaR NOt
product: MODEL1310110034#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110034#
name: NO transport (diffusion)

metaR r1576
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR ACALDtm
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM fpram c
is: HMDB06211
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:58478
initial amount: NaN
is: C04640
constant: false
boundary condition: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

metaR r2517
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
type: Reaction
reversible: true

metaM Rtotal e
initial concentration: 1.0
is: CHEBI:3554
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
name: R total
type: Species
is: HMDB00244
boundary condition: false

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
has only substance units: false
is: HMDB01262
initial concentration: 1.0
is: C01835
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: maltotriose
is: CHEBI:27931

metaM cs e deg5 l
is: SBO:0000247
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
type: Species
is: CHEBI:57737
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: HMDB00868

metaM cs d deg5 l
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00812
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 5
type: Species
is: SBO:0000247
is: CHEBI:16953
has only substance units: false

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110034#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false

metaM cmpacna n
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01176
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)

http://identifiers.org/biomodels.db/MODEL1310110034#_b9347a8f_66fb_46c4_a424_1cedbcf63067
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _2544_1_c
initial concentration: NaN
is encoded by: hsa:2544
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_6762aac2_cf28_42a8_b82a_b5b35a550e33
is: P22303
is encoded by: hsa:43
name: ACHE
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_1a9dda3c_98f1_49a8_ac6a_ac9d308386fe
constant: false
is: SBO:0000252
initial amount: NaN
is: Q13057
boundary condition: true
has only substance units: false
initial concentration: NaN
name: COASY
is encoded by: hsa:80347
type: Species

metaR r2516
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_30827e9f_200f_4944_b2e3_820df148c20b
is encoded by: hsa:7498
initial concentration: NaN
is: P47989
initial amount: NaN
constant: false
name: XDH
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR BETALDHxm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
is: SBO:0000176
fast: false
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reversible: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaR 2OXOADPTm
kinetic law: MODEL1310110034#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
modifier: MODEL1310110034#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR PROt4 2 r
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: Proline transport (sodium symport) (2:1)
reversible: true
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000006
is: SBO:0000185

metaR C3STKR2r
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110034#
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
reversible: false
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR r1578
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#

metaM Rtotal3 c
name: R total 3 position
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
is: HMDB01448
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaM Rtotal c
is: HMDB01448
type: Species
initial concentration: 1.0
name: R total
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110034#_b5186e0b_9985_4346_b0c0_ab23ec5f1a51
is: SBO:0000252
is: E7EML0
is encoded by: hsa:9498
name: SLC4A8
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM 1glyc hs e
name: 1 acyl phosphoglycerol
is: HMDB00224
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
is: CHEBI:58190
is: SBO:0000247

metaR NACHEXA5ly
product: MODEL1310110034#
reactant: MODEL1310110034#
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
reversible: false

metaR r1644
reactant: MODEL1310110034#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true

metaR r0502
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.113
is described by: ECO:0000000
product: MODEL1310110034#

metaR DURIt
is: SBO:0000185
reversible: true
name: deoxyuridine transport via diffusion
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaM hs deg10 l
is: SBO:0000247
constant: false
is: CHEBI:15748
name: heparan sulfate, degradation product 10
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110034#_b4dd6775_6762_4352_8f57_12be5b59398e
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q16881
name: TXNRD1
is encoded by: hsa:7296
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_3170819f_d9cb_4dc3_9314_6e7f9aada908
has only substance units: false
is encoded by: hsa:6240
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6241
initial amount: NaN
constant: false
has part: P23921
is: SBO:0000297
has part: P31350
type: Species
name: RRM1:RRM2

http://identifiers.org/biomodels.db/MODEL1310110034#_68bf0bc4_1092_4a7e_b5c2_474cc333969b
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9NVS9
is: SBO:0000252
boundary condition: true
name: PNPO
is encoded by: hsa:55163
has only substance units: false

metaR r0083
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
modifier: MODEL1310110034#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110034#
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110034#_a03a3365_0342_42a2_affa_4461ae9bb835
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5151
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PDE8A

metaR IDOAASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false

metaR r0822
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_52c2c503_8044_416b_a1a0_8f381e14d61c
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5092
is: P61457
name: PCBD1

metaM cmpacna c
initial amount: NaN
is: HMDB01176
boundary condition: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false

metaM udp g
initial amount: NaN
is: HMDB00295
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
has only substance units: false
boundary condition: false
name: UDP(3-)
constant: false
is: CHEBI:58223
initial concentration: 1.0

metaR r1645
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_3ec64379_6659_4a45_a7f7_8fe0e7d1d118
boundary condition: true
name: _H17063_1_c
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:H17063
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_909890fe_dd15_444e_9e6c_ce4d11e39a65
constant: false
initial concentration: NaN
has only substance units: false
name: ALDOA
is encoded by: hsa:226
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_da0a5a59_b0a6_4232_a55e_d1def3048bac
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q9BV79
boundary condition: true
is: SBO:0000252
name: MECR
is encoded by: hsa:51102
initial amount: NaN

metaR LCYSTAT
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110034#
reversible: true
name: L-Cysteate:2-oxoglutarate aminotransferase
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_34116b61_bfd8_40b6_9976_caf952a0b313
is: Q5SYN6
name: SLC22A3
is encoded by: hsa:6581
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR DOPAtu
product: MODEL1310110034#
is described by: ECO:0000269
name: Dopamine uniport
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110034#
fast: false
reversible: true
kinetic law: MODEL1310110034#
is: SBO:0000185

metaR r1646
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true

metaM leu L m
has only substance units: false
is: HMDB00687
boundary condition: false
constant: false
name: L-leucine
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR NRPPHRSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
is: SBO:0000185
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
type: Reaction
name: norepinephrine sulfate transport (diffusion)
reactant: MODEL1310110034#

metaR r0085
is: SBO:0000176
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110034#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false

metaM cspg b e
initial amount: NaN
is: HMDB00630
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
boundary condition: false
is: CHEBI:16040
type: Species
has only substance units: false
initial concentration: 1.0

metaM 5aizc c
boundary condition: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species
constant: false
is: C04751
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: SBO:0000247
is: CHEBI:58564
is: HMDB06273
initial concentration: 1.0
initial amount: NaN

metaR ACGALtly
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
fast: false
name: N-acetyl-galactosamine lysosomal efflux
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000

metaR CYTK13n
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110034#
fast: false
reversible: true

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Utilized transport
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
fast: false
type: Reaction
reversible: true

metaR RE2658R
is: SBO:0000176
reversible: true
fast: false
name: RE2658
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_0cffdf8b_903a_4fec_8167_54368cc8ff22
boundary condition: true
name: SLC24A1
has only substance units: false
type: Species
is encoded by: hsa:9187
is: SBO:0000252
initial amount: NaN
constant: false
is: B4DUG1
initial concentration: NaN

metaM udp e
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: UDP(3-)
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58223
constant: false

metaR r1647
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1421
type: Reaction
reversible: true
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000185
name: Free diffusion
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

metaM leuktrD4 c
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03080
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28666
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_2262704f_4f07_4034_8c93_429ada48f739
name: INPP5J
initial amount: NaN
constant: false
initial concentration: NaN
is: Q15735
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:27124

metaR r0145
type: Reaction
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110034#

metaR r0084
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
reactant: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_fbe6e2d0_4d10_4112_9818_37d70830285b
initial concentration: NaN
constant: false
is: Q9Y6M9
is encoded by: hsa:4715
name: NDUFB9
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR CYTK5n
fast: false
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110034#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2695cbcb_cc76_452a_8ffb_0743af7185c9
is: Q96Q11
boundary condition: true
name: TRNT1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51095
constant: false

metaM xol7ah c
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:2290
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial amount: NaN
is: HMDB06892
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_da31ffd8_14f6_44e4_85e3_635368ec302f
initial amount: NaN
has only substance units: false
name: LEFTY1
initial concentration: NaN
is: SBO:0000252
is: O75610
boundary condition: true
is encoded by: hsa:10637
type: Species
constant: false

metaM 2mbcoa m
is: HMDB01041
constant: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
boundary condition: false
is: CHEBI:57336
type: Species
is: SBO:0000247
has only substance units: false
name: 2-methylbutanoyl-CoA(4-)
initial amount: NaN

metaM HC01602 c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
is: CHEBI:57454
is: C00234
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_5348b8e5_599b_4f5f_83a0_f85ec055c312
has only substance units: false
constant: false
is encoded by: hsa:51301
name: GCNT4
is: Q9P109
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaM amet c
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
is: HMDB01185
is: SBO:0000247

metaR FACOAL80i
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
is described by: ECO:0000269

metaM val L c
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
has only substance units: false
is: HMDB00883
type: Species
is: CHEBI:16414
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaR r1640
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_72c1cba5_ef95_49d1_a57d_6fbdb14c9831
initial amount: NaN
name: ACHE
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:43
initial concentration: NaN

metaR FAOXC5OHc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
constant: false
is: HMDB01176
has only substance units: false
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM HC01403 x
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247

metaM udp c
is: CHEBI:58223
is: C00015
is: HMDB00295
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
boundary condition: false
name: UDP
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_ec0b4d59_a541_47ce_bdae_db564f531156
is encoded by: hsa:9091
has part: O94777
has part: B3KUV7
is: SBO:0000297
constant: false
is encoded by: hsa:5279
has only substance units: false
is encoded by: hsa:5277
is encoded by: hsa:8818
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: Q9BRB3
is encoded by: hsa:51227
type: Species
boundary condition: true
has part: Q14442
initial concentration: NaN
is encoded by: hsa:5283
has part: Q92535

metaR PGS
kinetic law: MODEL1310110034#
name: Prostaglandin G/H synthase
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.14.99.1
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaM arachd c
boundary condition: false
is: HMDB01043
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
initial amount: NaN
is: CHEBI:32395
is: SBO:0000247
initial concentration: 1.0

metaM pail45p hs m
is: CHEBI:28910
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
initial concentration: 1.0

metaM HC01231 m
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
type: Species
is: CHEBI:58480
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR SUCRe
is described by: ECO:0000269
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.10
is version of: http://identifiers.org/ec-code/3.2.1.20
name: sucrose hydrolyzing enxyme, extracellular
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_90bd60c3_b6ca_481d_8bea_be01259a3cdc
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
is: P49748
name: ACADVL
is encoded by: hsa:37
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_30da1c3c_f56a_478b_8284_5a713fe09e0d
initial amount: NaN
boundary condition: true
name: _D87002_1_e
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:D87002
is: SBO:0000252
type: Species

metaR r1641
is described by: ECO:0000000
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_8a79b291_46f1_4ee0_9323_d427fefd2762
is: SBO:0000252
initial amount: NaN
name: GCK
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2645
has only substance units: false

metaR P450SCC1m
name: cholesterol monooxygenase
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reactant: MODEL1310110034#
is described by: ECO:0000134
fast: false

metaR r0504
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
modifier: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR r0829
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_8385656e_3b9f_4b16_b956_d636f409f249
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5150
initial amount: NaN
boundary condition: true
name: PDE7A
constant: false
is: SBO:0000252
is: Q13946
type: Species

metaM cs a deg3 l
type: Species
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00127
notes: FORMULA: C31H48NO32S2 CHARGE: -3
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
constant: false
has only substance units: false

metaM h2o c
is: CHEBI:3303
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: H2O
has only substance units: false
notes: FORMULA: H2O CHARGE: 0
is: C00001
is: HMDB02111
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_0eb9fe9a_1cc5_4f4f_8b03_2fdf1134bcd7
name: SLC25A2
has only substance units: false
initial amount: NaN
is: Q9BXI2
is encoded by: hsa:83884
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0081
reversible: true
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
product: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR PRODt2r
fast: false
product: MODEL1310110034#
is described by: ECO:0000304
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d201eb5c_63b3_4658_a28a_0ca98bc5d484
is: O14986
is encoded by: hsa:8395
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: PIP5K1B

metaR NACHEX16ly
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
product: MODEL1310110034#
name: Isopentenyl diphosphate transport (peroxisome)
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110034#
fast: false
reversible: true
reactant: MODEL1310110034#
type: Reaction

metaR r1642
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
modifier: MODEL1310110034#

metaM ga1 hs g
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58524
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI: InChI=1S/C19H24O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h10-13,20,24H,1,3-8H2,2H3,(H,21,22)/p-1/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
is: SBO:0000247
name: gibberellin A1(1-)

metaR NACHEX2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110034#

metaR r0149
modifier: MODEL1310110034#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110034#

metaR ENGASE3ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110034#

metaR r1643
fast: false
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR EX tetdece1crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaM arachd e
constant: false
is: HMDB01043
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
name: arachidonate
is: SBO:0000247
is: CHEBI:32395
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_8bc186ac_01e8_46ef_aa52_c0d0c9d661e4
constant: false
is encoded by: hsa:51733
has only substance units: false
name: UPB1
type: Species
is: SBO:0000252
boundary condition: true
is: B3KNC1
initial amount: NaN
initial concentration: NaN

metaM h2o e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
type: Species
boundary condition: false
is: HMDB02111
constant: false
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110034#_fb1c1ebc_1b62_434a_b3bc_9dcb1ad48bb1
type: Species
boundary condition: true
initial concentration: NaN
has part: B4DY56
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
initial amount: NaN
constant: false
is encoded by: hsa:498
has only substance units: false

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR RE2974C
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.68
is described by: ECO:0000000
product: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.149
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110034#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#

metaR PPCDC
reversible: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110034#
name: phosphopantothenoylcysteine decarboxylase

metaM prostgh2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: SBO:0000247
is: HMDB01381
name: prostaglandin H2(1-)
is: CHEBI:57405
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_b2db0263_227e_4808_b1d6_d0b6377d6631
is: Q542Y6
boundary condition: true
constant: false
name: PLA2G12A
is encoded by: hsa:81579
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM fucfucgalacglcgalgluside hs e
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: HMDB00660
has only substance units: false
is: CHEBI:15824
initial amount: NaN
boundary condition: false
name: Leb glycolipid
is: C00095
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR EX gp1calpha hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GP1c alpha (homo sapiens) exchange
type: Reaction

metaM leugly c
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
has only substance units: false
name: Leucylglycine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_7a3ee993_0137_43a2_b772_18b58204f25b
type: Species
is: P48448
initial concentration: NaN
name: ALDH3B2
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:222
constant: false
is: SBO:0000252

metaM ocdca c
type: Species
initial amount: NaN
name: stearate
has only substance units: false
boundary condition: false
is: CHEBI:25629
constant: false
is: HMDB00827
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_f693a773_d713_4167_9e03_7d16edf76628
has only substance units: false
is: Q5FC00
is: SBO:0000252
constant: false
type: Species
name: CA6
initial amount: NaN
is encoded by: hsa:765
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_d315a6a5_a5f8_41df_82b9_8ffca8456465
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9NYW8
is encoded by: hsa:57786
name: RBAK

metaR TYRCBOX
is: SBO:0000176
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000134
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: L-Tyrosine carboxy-lyase

http://identifiers.org/biomodels.db/MODEL1310110034#_531290c0_6057_4421_b33d_c6caea56dbff
boundary condition: true
is encoded by: hsa:160728
is: Q8N695
name: SLC5A8
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_6966a4a4_3824_4885_a57e_cf8fed28d03a
has only substance units: false
is encoded by: hsa:4830
is: SBO:0000252
is: P15531
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110034#_abe951d4_4c17_4d07_8a84_e8337415294e
type: Species
is encoded by: hsa:128
initial concentration: NaN
constant: false
name: ADH5
has only substance units: false
is: SBO:0000252
is: Q6IRT1
initial amount: NaN
boundary condition: true

metaR S6TASE10ly
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176

metaM pail hs c
type: Species
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM cs d deg2 l
is: SBO:0000247
is: HMDB00812
boundary condition: false
has only substance units: false
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2
is: CHEBI:16953
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6

metaR RE2649C
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
reversible: true
name: RE2649
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is: SBO:0000176

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB11631
constant: false
name: 3-hydroxy-L-kynurenine
is: CHEBI:17380
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM leugly e
boundary condition: false
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: Leucylglycine
has only substance units: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM fucfucgalacglcgalgluside hs c
constant: false
type: Species
has only substance units: false
is: CHEBI:18287
is: HMDB00174
name: Leb glycolipid
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: SBO:0000247

metaR r1429
is: SBO:0000185
fast: false
name: Free diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#

metaM HC01406 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 3-Oxooctanoyl-CoA
is: CHEBI:28264
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0848fb98_3c3f_48fc_929c_3e742df7d4a5
type: Species
is encoded by: hsa:2819
constant: false
boundary condition: true
is: F8W1L5
initial concentration: NaN
name: GPD1
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_72c50a8f_44e7_4f66_8bc6_ad462fcd7f0e
has only substance units: false
constant: false
is: O95470
name: SGPL1
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8879
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_917bb15a_e57e_4a62_b47c_780c40219ed9
initial amount: NaN
is: SBO:0000252
name: NDUFA13
has only substance units: false
boundary condition: true
is: Q9P0J0
initial concentration: NaN
is encoded by: hsa:51079
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_ba73963c_8de4_4f03_a741_63c9ea395832
constant: false
has only substance units: false
initial amount: NaN
name: GBA
is: SBO:0000252
boundary condition: true
is: B7Z6S1
initial concentration: NaN
is encoded by: hsa:2629
type: Species

metaM ocdca e
boundary condition: false
constant: false
type: Species
name: octadecanoate (n-C18:0)
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
initial amount: NaN
is: HMDB00827
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e7086831_8436_485d_b869_7585c8ab18e3
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:276
type: Species
initial concentration: NaN
name: AMY1A
is: Q6NSB3

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR ACACT6p
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110034#_19770b6d_3b91_4d65_a8b5_4640be6438ad
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACAT1
is: SBO:0000252
type: Species
initial concentration: NaN
is: P24752
is encoded by: hsa:38

metaR CMPSAS
is described by: ECO:0000304
name: CMP sialic acid synthase
reversible: false
product: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

metaR AKGt4 3
name: AKG transport via sodium symport
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES:NCD
kinetic law: MODEL1310110034#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110034#

metaM pyr m
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:15361
is: C00022
constant: false
type: Species
is: HMDB00243
name: pyruvate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN

metaR r1428
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110034#
name: Free diffusion
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_39cd3d0b_b434_4ca8_bd48_b8cf2531f65c
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:3284
type: Species
is: P26439
initial amount: NaN
name: HSD3B2
has only substance units: false

metaR PGK
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.2.3
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
reversible: true
name: phosphoglycerate kinase
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110034#
is described by: ECO:0000134
kinetic law: MODEL1310110034#

metaM decdicrn c
initial amount: NaN
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
type: Species
is: HMDB13325
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR r0074
is: SBO:0000176
kinetic law: MODEL1310110034#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
type: Reaction
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110034#_26f02bd4_a7c0_474d_b873_4ef4d0e7fce8
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:279
initial concentration: NaN
is: P04746
name: AMY2A
boundary condition: true
has only substance units: false

metaM leuktrD4 e
constant: false
name: Leukotriene D4
is: HMDB03080
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
is: CHEBI:28666

http://identifiers.org/biomodels.db/MODEL1310110034#_3db5842a_a1a5_432a_b45b_dbed05787486
has only substance units: false
is encoded by: hsa:3418
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: IDH2
is: P48735

metaR NADPtru
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110034#
name: NADP transporter, endoplasmic reticulum
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_07546600_7024_434d_837b_6f24588532c6
type: Species
name: IMPA2
constant: false
is encoded by: hsa:3613
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O14732
boundary condition: true

metaM HC01414 x
has only substance units: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
initial amount: NaN
name: trans-dec-2-enoyl-CoA(4-)
is: CHEBI:61406
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f6420220_fd48_4a6c_8d6c_75636dc36a53
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: ATP5J
initial concentration: NaN
type: Species
is encoded by: hsa:522
boundary condition: true

metaR GLNLASEer
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is: SBO:0000176
name: gluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_5b3b444c_3e93_4961_b8b9_7c64c04fdcae
is: B4DK61
initial amount: NaN
is: SBO:0000252
name: ACOX1
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:51
constant: false
type: Species

metaR GAPD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110034#
type: Reaction
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reversible: true
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_5f618c8b_f1c6_4138_8ac9_c596062e26fb
is: P27708
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: CAD
is encoded by: hsa:790

metaR r0830
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false

metaR NDPK5n
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is described by: ECO:0000304
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_5786469b_b16d_4063_9bea_5b6b61ce53d3
is encoded by: hsa:516
initial amount: NaN
initial concentration: NaN
type: Species
has part: Q6FIH7
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2

metaM 10fthf7glu e
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
is: HMDB00224
boundary condition: false
is: SBO:0000247
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110034#_b97bb163_e6f2_42c9_8cd6_1e4075c8ff30
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3099
has only substance units: false
initial amount: NaN
boundary condition: true
is: P52789
initial concentration: NaN
name: HK2

metaM cspg b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
has only substance units: false
boundary condition: false
is: HMDB06202
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM decdicrn e
initial concentration: 1.0
has only substance units: false
is: HMDB13325
name: decadienoyl carnitine
type: Species
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN

metaM HC01403 m
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial amount: NaN
boundary condition: false
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_fea418a9_be8a_44be_b5e5_c598be781eaf
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: SLC8A3
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6547

http://identifiers.org/biomodels.db/MODEL1310110034#_cfd80690_950f_402a_91ef_e0f421bcbf6f
is: O75947
name: ATP5H
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10476
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM fucfucgalacglcgalgluside hs g
name: Leb glycolipid
is: HMDB00174
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: CHEBI:18287
has only substance units: false

metaR INSTt4 2
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
modifier: MODEL1310110034#
reversible: true
name: inositol transport via sodium symport
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR ILETAm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
type: Reaction
reactant: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: isoleucine transaminase, mitochondrial
is: SBO:0000176
product: MODEL1310110034#

metaM trdrd c
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Reduced thioredoxin
boundary condition: false
is: CHEBI:15967

http://identifiers.org/biomodels.db/MODEL1310110034#_e06ed418_143f_45a7_8337_611ae22a054f
type: Species
boundary condition: true
is encoded by: hsa:50814
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q15738
initial concentration: NaN
name: NSDHL

http://identifiers.org/biomodels.db/MODEL1310110034#_10294edf_2bae_44b0_b9cf_69813bdcf755
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q86YU0
constant: false
name: CA7
is encoded by: hsa:766
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_2a9aef05_0f3d_4f29_9587_b2d34bc59eb7
has only substance units: false
name: NME1
constant: false
is encoded by: hsa:4830
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM prostgf2 e
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01139
is: CHEBI:57404
constant: false
is: SBO:0000247

metaR S6TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
fast: false
reversible: true

metaR INSK
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000176
name: insosine kinase
fast: false
reversible: false
is described by: ECO:0000134
product: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ca2e505c_1ac7_4d98_b20e_bd5c793257b2
has only substance units: false
name: ATP5L
initial amount: NaN
is: SBO:0000252
constant: false
is: O75964
initial concentration: NaN
is encoded by: hsa:10632
type: Species
boundary condition: true

metaR LNLNCGt
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_933a4683_06d4_436e_ab04_d112de2d41bb
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: Q05C14
boundary condition: true
name: FOLR3
constant: false
has only substance units: false
is encoded by: hsa:2352

metaR DHEAtr
product: MODEL1310110034#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: Dehydroepiandrosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
type: Reaction

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR GUAt
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
kinetic law: MODEL1310110034#
name: Guanine transport
reversible: true
reactant: MODEL1310110034#
fast: false

metaM dolmanp U r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
is: CHEBI:15809
has only substance units: false
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
type: Species

metaR ACITL
name: ATP-Citrate lyase
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.3.8
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction

metaM Rtotal3 e
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
has only substance units: false
boundary condition: false
name: R total 3 position
is: C00255
type: Species
constant: false
is: HMDB00244
initial amount: NaN
is: CHEBI:3554
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_b43b401a_97c8_4694_93f7_2b3bf994d280
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q9NST1
is encoded by: hsa:80339
name: PNPLA3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_5e2a60d8_0880_4853_8ac0_23cdf31034e4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: SLC24A2
constant: false
is: Q9UI40
is encoded by: hsa:25769

metaR GPDDA1
reversible: false
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110034#_8c7f429f_3706_431f_9f62_54f627d0b134
name: HSD17B4
initial amount: NaN
boundary condition: true
is encoded by: hsa:3295
type: Species
is: E9PB82
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR RE3269C
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
name: RE3269
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is version of: http://identifiers.org/ec-code/3.1.3.48
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_37f5a89c_34cc_40ee_9ffb_1e559f4b1f27
type: Species
has only substance units: false
is encoded by: hsa:4716
constant: false
is: SBO:0000252
name: NDUFB10
is: A8K761
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_dacc6a9e_8249_4e57_afab_f98f6190ee7f
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: Q96SL4
has only substance units: false
constant: false
name: GPX7
boundary condition: true
is encoded by: hsa:2882

http://identifiers.org/biomodels.db/MODEL1310110034#_293d7ca6_39c7_45ae_8997_2c31baf9516f
initial concentration: NaN
name: _AA576959_1_c
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AA576959
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_ea2cac41_bc04_4007_b348_5a234438a27e
initial amount: NaN
is encoded by: hsa:2027
type: Species
initial concentration: NaN
name: ENO3
is: SBO:0000252
boundary condition: true
constant: false
is: D3DTL2
has only substance units: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR r0940
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110034#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: Free diffusion
is: SBO:0000185

metaM pyr c
is: HMDB00243
is: CHEBI:15361
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
is: C00022

metaR IVCOAACBP
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_eec79383_9d09_4950_a568_66c8866ab715
name: PPAP2C
constant: false
is: SBO:0000252
is: E9PAY8
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8612

metaR r1579
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110034#
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_763420e8_e547_4031_a65f_d12eae3a1ba0
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:64849
is: SBO:0000252
is: Q8WWT9
name: SLC13A3
boundary condition: true
constant: false

metaR r0941
is described by: ECO:0000000
reversible: true
name: Free diffusion
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_521f9f35_7fe3_47a0_a8a8_543c6133d0f6
is: SBO:0000297
is encoded by: hsa:3420
initial concentration: NaN
has part: E9PDD5
type: Species
has part: P50213
has only substance units: false
is encoded by: hsa:3419
boundary condition: true
name: IDH3A:IDH3B:IDH3G
constant: false
is encoded by: hsa:3421
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_a8561521_c99a_48d8_9df0_b36af5e769ea
boundary condition: true
initial concentration: NaN
type: Species
is: Q7Z364
has only substance units: false
name: PDE1B
initial amount: NaN
is encoded by: hsa:5153
constant: false
is: SBO:0000252

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR CITRtm
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000269
name: citrulline mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reversible: true
is: SBO:0000185
product: MODEL1310110034#

metaM retinol 9 cis c
type: Species
initial concentration: 1.0
initial amount: NaN
name: 9-cis-retinol
is: SBO:0000247
is: CHEBI:17336
constant: false
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: HMDB06217
has only substance units: false

metaR PGI
is version of: http://identifiers.org/ec-code/5.3.1.9
type: Reaction
fast: false
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000134
name: glucose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is: SBO:0000176

metaM HC01231 c
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
initial amount: NaN
is: SBO:0000247

metaR r0942
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reversible: true
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4

metaM pyr e
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
initial amount: NaN
initial concentration: 1.0
name: pyruvate
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:15361

metaR HSAT2ly
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000

metaR APOC LYS BTNP
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
name: proteolysis of apoC-Lys-btn
fast: false
reversible: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR BTND1
type: Reaction
name: biotinidase (biotin)
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT

metaR CLFORtex
type: Reaction
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
name: chloride transport via formate countertransport
modifier: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000304
reversible: false
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR L LACt4r
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#

metaM 3ivcrn e
has only substance units: false
type: Species
constant: false
is: HMDB13325
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxy-isovaleryl carnitine
notes: FORMULA: C12H23NO5 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaM ksi deg3 l
name: keratan sulfate I, degradation product 3
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01356
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: SBO:0000247
is: CHEBI:57312

metaR XOLDIOLONEt
reactant: MODEL1310110034#
fast: false
name: lipid, flip-flop intracellular transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR PIt8
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000185
name: phosphate transport in/out via Na+ symporter
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110034#
reversible: true
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#

metaM 3ddcrn e
boundary condition: false
is: HMDB00791
notes: FORMULA: C19H37NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 3-hydroxydodecanoylcarnitine
is: C02838
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5110f89f_1d03_4696_a1d9_304b1f85dec7
name: _D29675_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:D29675
type: Species
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_e5fa67ad_8d81_48d6_b8ff_43a079574589
initial amount: NaN
is encoded by: hsa:2517
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: P04066
name: FUCA1
has only substance units: false
type: Species

metaR G5SADrm
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110034#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR PIt7
is: SBO:0000185
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
reactant: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2002f4c1_46b3_4260_9bb1_025c1aa5662c
type: Species
name: SLC4A5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:57835
is: Q9BY07
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_537ef380_c222_4929_83e6_610c5295da56
is: Q9UGH3
is: SBO:0000252
name: SLC23A2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9962
initial amount: NaN
type: Species
has only substance units: false

metaR PHETHPTOX2
is described by: ECO:0000269
reactant: MODEL1310110034#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
is version of: http://identifiers.org/ec-code/1.14.16.1
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
modifier: MODEL1310110034#

metaM 3ivcrn c
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06870
constant: false
is: C05998
name: 3-hydroxy-isovaleryl carnitine
initial amount: NaN
notes: FORMULA: C12H23NO5 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_530e87bc_8156_4b6c_b7ba_209c5f50220c
initial amount: NaN
constant: false
has only substance units: false
is: P25325
name: MPST
is encoded by: hsa:4357
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR RE1522M
modifier: MODEL1310110034#
reversible: true
is described by: ECO:0000000
name: RE1522
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR S3TASE3ly
is: SBO:0000176
name: N-acetylglucosamine-3-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
type: Reaction
product: MODEL1310110034#

metaM HC00229 e
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false
name: Isomaltose
initial amount: NaN
type: Species
is: CHEBI:28189

metaM 3ddcrn c
boundary condition: false
is: HMDB00623
notes: FORMULA: C19H37NO5 CHARGE: 0
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_93cdf95e_6aa9_4aba_8a9c_c585c925dbf5
type: Species
name: ACAA1
boundary condition: true
constant: false
is: Q96CA6
has only substance units: false
is encoded by: hsa:30
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_a8598a69_3972_4b22_b238_81c7809128bb
initial concentration: NaN
type: Species
is encoded by: hsa:9963
is: SBO:0000252
boundary condition: true
name: SLC23A1
initial amount: NaN
is: Q9UHI7
has only substance units: false
constant: false

metaM prostgh2 e
is: SBO:0000247
constant: false
type: Species
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
is: CHEBI:57405
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_1908d992_3edf_4a53_bade_ab40856e563e
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9H999
is: SBO:0000252
type: Species
name: PANK3
constant: false
is encoded by: hsa:79646
initial concentration: NaN

metaR GALNTg
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110034#
is described by: ECO:0000000
name: GalNAc transferase, Golgi apparatus
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.1.41
type: Reaction
reactant: MODEL1310110034#
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d7a41dc5_1152_4622_a2d4_7881641678e7
initial concentration: NaN
is: O95528
initial amount: NaN
type: Species
constant: false
name: SLC2A10
is encoded by: hsa:81031
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_cd96516a_6481_407a_8712_c482a82ad9e7
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:55811
is: SBO:0000252
name: ADCY10
initial amount: NaN
is: F5GWS5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_96657a6d_e519_43ff_806b_8b4932e52adb
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9NZ20
constant: false
initial concentration: NaN
name: PLA2G3
type: Species
initial amount: NaN
is encoded by: hsa:50487

metaR RE3565C
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
name: RE3565
reversible: true
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_cf41bca6_4bb3_480a_a326_6694c2068e0e
name: OXSM
is: Q9NWU1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54995
has only substance units: false
type: Species
constant: false

metaR HXANtx
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
reversible: false
is described by: ECO:0000000
name: hypoxanthine diffusion in peroxisome
fast: false
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM mi145p c
type: Species
initial amount: NaN
boundary condition: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial concentration: 1.0
has only substance units: false
is: HMDB01498
is: CHEBI:203600
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_392f3029_e819_48c9_a0d8_99c54d335199
is: SBO:0000252
is: B2R6S5
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: CMPK1
type: Species
boundary condition: true
is encoded by: hsa:51727

http://identifiers.org/biomodels.db/MODEL1310110034#_fbb636ad_c034_45fd_b2b7_d13656224029
is: P32929
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: CTH
constant: false
has only substance units: false
is encoded by: hsa:1491
initial concentration: NaN

metaM CE2839 e
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
name: maltodecaose
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C01936
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_41ab68e6_0bd5_4d8e_88e1_0fe682398f8c
is: Q15067
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: ACOX1
boundary condition: true
is encoded by: hsa:51
has only substance units: false
is: SBO:0000252

metaR r0946
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_b2a72927_2b1c_4069_8fca_427c19e1f5b7
initial concentration: NaN
is: Q7Z3X3
boundary condition: true
has only substance units: false
name: GNS
constant: false
is encoded by: hsa:2799
is: SBO:0000252
type: Species
initial amount: NaN

metaR CHLtm
reactant: MODEL1310110034#
is: SBO:0000185
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_98d19557_36e6_4a98_9188_04501592961e
is: SBO:0000252
initial amount: NaN
type: Species
name: _286297_1_c
initial concentration: NaN
is encoded by: hsa:286297
boundary condition: true
has only substance units: false
constant: false

metaR EX c5dc
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM h2o2 x
name: Hydrogen peroxide
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: C00027
is: CHEBI:16240
initial concentration: 1.0
is: SBO:0000247
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110034#_e2de33f9_1cfc_4287_b315_1c50a1e05a9c
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348
initial concentration: NaN
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110034#_bb50b13b_46df_4961_8d84_3f9cd4454682
type: Species
constant: false
is encoded by: hsa:80025
has only substance units: false
boundary condition: true
name: PANK2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r1565
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_b9eef866_4c57_4ec3_8f60_efac8dd855b9
constant: false
has only substance units: false
initial amount: NaN
name: RRM2
is encoded by: hsa:6241
initial concentration: NaN
type: Species
boundary condition: true
is: P31350
is: SBO:0000252

metaR DDECE1CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_496cd0fc_cb11_4a90_84ca_31ea50c71b9c
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:54981
name: NMRK1
is: SBO:0000252
type: Species
is: Q9NWW6
initial concentration: NaN

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM hs deg5 l
constant: false
boundary condition: false
is: CHEBI:17895
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
initial concentration: 1.0
is: HMDB00158
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 5

metaM dhf e
is: CHEBI:57451
initial concentration: 1.0
type: Species
name: dihydrofolate(2-)
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
boundary condition: false
is: HMDB01056

metaR r0267
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.9
reversible: true
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176

metaR ST3GAL22g
modifier: MODEL1310110034#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR r1566
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#

metaM 7thf e
is: HMDB06559
constant: false
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false
initial amount: NaN
name: heptaglutamyl folate (THF)
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_aaca41ec_2641_4c98_b4c7_4026d31e71d9
is: SBO:0000252
constant: false
initial amount: NaN
is: P54868
has only substance units: false
name: HMGCS2
initial concentration: NaN
type: Species
is encoded by: hsa:3158
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_89e51cf5_dd08_4683_9e64_a4f95f457072
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:112
is: O43306
name: ADCY6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_346e46fd_a105_49ae_a93d_9bb61ba42354
constant: false
is encoded by: hsa:5831
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: A6NFM2
name: PYCR1
has only substance units: false

metaM dcmp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
type: Species
name: dCMP(2-)
has only substance units: false
initial concentration: 1.0
constant: false

metaM mi1345p c
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: HMDB01059
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57895

http://identifiers.org/biomodels.db/MODEL1310110034#_0a4a80e7_0058_4e20_8fdb_79e6890a4254
initial amount: NaN
boundary condition: true
name: ACP1
is: Q59EH3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:52

http://identifiers.org/biomodels.db/MODEL1310110034#_e63e22d4_a131_4958_84df_d21d70c32b37
is: SBO:0000252
is: C9JFZ1
is encoded by: hsa:8867
initial concentration: NaN
type: Species
has only substance units: false
name: SYNJ1
constant: false
boundary condition: true
initial amount: NaN

metaR DHCHOLESTANATEtm
name: lipid, flip-flop intracellular transport
fast: false
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
is: SBO:0000185

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ba866c9e_6730_48cd_a3b4_39ca2e47aec5
type: Species
is encoded by: hsa:114
constant: false
is: SBO:0000252
name: ADCY8
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q4F7X0

metaR SERGLNexR
modifier: MODEL1310110034#
is described by: ECO:0000304
reversible: true
fast: false
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#

metaR r2506
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
name: Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_2192b49b_a541_468d_aa1b_e1bbdbdbcb3f
is encoded by: hsa:9060
type: Species
initial concentration: NaN
initial amount: NaN
name: PAPSS2
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O95340
constant: false

metaR r0944
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
fast: false
product: MODEL1310110034#
name: Active transport
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_167c3423_b718_4f80_aefa_df5dbcadf6b8
initial concentration: NaN
name: NME4
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O00746
is encoded by: hsa:4833
constant: false
type: Species
has only substance units: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR 2AMADPTm
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
type: Reaction
modifier: MODEL1310110034#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
fast: false

metaM mi34p c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: HMDB06235
is: CHEBI:28858
initial concentration: 1.0
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_b9ca24c5_a416_4b06_87d5_edfadacca850
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: Q5FWF5
name: ESCO1
is encoded by: hsa:114799
constant: false
boundary condition: true

metaM dhcholestanate m
is: HMDB00359
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16577
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
constant: false

metaM dhf c
is: CHEBI:57451
is: HMDB01056
is: SBO:0000247
boundary condition: false
constant: false
name: 7,8-Dihydrofolate
has only substance units: false
type: Species
initial amount: NaN
is: C00415
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR r1563
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185

metaM dtdp m
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial concentration: 1.0
is: C00363
is: HMDB01274
name: dTDP
initial amount: NaN
type: Species
is: CHEBI:58369
boundary condition: false

metaR TYMSULT
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110034#
name: Tyramine Sulfotransferase
is described by: ECO:0000269
kinetic law: MODEL1310110034#

metaR r1106
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110034#
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR URATEtx
fast: false
reversible: false
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110034#
name: urate export from peroxisome
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_dcc853c0_e63a_4c69_b594_e08eca78c03a
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: GALT
boundary condition: true
is: B2RAT6
initial concentration: NaN
is encoded by: hsa:2592
constant: false
type: Species

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f9d8b495_fb33_44b4_a0db_9797435f4f29
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:518
has only substance units: false
type: Species
boundary condition: true
name: ATP5G3
initial amount: NaN

metaM dtdp n
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01274
initial amount: NaN
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM CE2838 e
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial concentration: 1.0
name: maltononaose
is: C01936

metaR RE2649M
name: RE2649
product: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton

metaR r1564
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_bf4db043_f7f7_4ee5_8fac_b17cf78a7cfd
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4967
has part: B4E3E9
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX

metaR MI4PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: false

metaR S2TASE5ly
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.18 Confidence Level: 4 AUTHORS: PMID:2497731,PMID:4019466,PMID:8993162 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
name: glucuronate-2-sulfatase, lysosomal
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction

metaR r1787
product: MODEL1310110034#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR ACNMLr
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
name: N-Acetylneuraminate lyase (reversible)

http://identifiers.org/biomodels.db/MODEL1310110034#_b9c47ee5_29a7_4eb2_9cd1_4fc079e3abc0
constant: false
is encoded by: hsa:4831
has only substance units: false
boundary condition: true
is: P22392
type: Species
initial amount: NaN
name: NME2
is: SBO:0000252
initial concentration: NaN

metaR C101CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e660bbeb_319b_4737_80cb_045ccf4c4fee
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:11227
is: SBO:0000252
is: A5PKZ1
name: GALNT5

metaR GLCNACASE4ly
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_88d191ac_303e_4bf5_bc51_0d8fcca8e804
has only substance units: false
is: O95169
initial amount: NaN
name: NDUFB8
is: SBO:0000252
type: Species
is encoded by: hsa:4714
constant: false
boundary condition: true
initial concentration: NaN

metaR PA HStn
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: phosphatidate transport, nuclear
product: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110034#

metaM hs deg23 l
constant: false
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:21338
has only substance units: false
is: HMDB02704
boundary condition: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species

metaR r1561
product: MODEL1310110034#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR LEUGLYHYc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
fast: false
name: hydrolysis of leucylglycine
is described by: ECO:0000134

metaM glc D c
name: D-glucose
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00122
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_53407d55_c4d7_4724_a36b_fec9d4755140
name: _AA854479_1_m
is: SBO:0000252
is encoded by: hsa:AA854479
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR r1562
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_7c2f7a84_f5cc_4354_862e_c694af8b1bc7
type: Species
constant: false
name: BCAT1
has only substance units: false
boundary condition: true
is: P54687
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:586

metaR HEXDICOAACBP
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2d14e16b_8009_44f9_b275_9d1cf836d2ec
is: P14060
boundary condition: true
type: Species
name: HSD3B1
has only substance units: false
is encoded by: hsa:3283
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c85468fa_55db_4050_b4b4_e7b84bc06fa1
initial concentration: NaN
is encoded by: hsa:6565
initial amount: NaN
type: Species
is: Q16348
boundary condition: true
name: SLC15A2
has only substance units: false
constant: false
is: SBO:0000252

metaR NADtn
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: NAD transport, nuclear through pores
product: MODEL1310110034#

metaR Htx
name: H transporter, peroxisome
is: SBO:0000185
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
reversible: true

metaM acrn x
constant: false
type: Species
is: CHEBI:57589
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: O-acetylcarnitine
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
has only substance units: false

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f54298ea_e34e_46ac_b42e_8c6fcdac9026
constant: false
type: Species
is: Q56NI9
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:157570
name: ESCO2
is: SBO:0000252

metaR RE1807C
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
reactant: MODEL1310110034#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

metaM pep m
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
boundary condition: false
is: HMDB00263
is: CHEBI:18021
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: C00074
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_feba205e_7c3b_40ab_a9db_4978b666fe1f
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6582
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC22A2

http://identifiers.org/biomodels.db/MODEL1310110034#_611373e0_3cbd_415b_99a9_3bce962f69a0
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:FLJ44968
initial concentration: NaN
name: _FLJ44968_1_m

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM gdpmann c
type: Species
initial concentration: 1.0
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527
initial amount: NaN
has only substance units: false
name: GDP-alpha-D-mannose(2-)
boundary condition: false
is: HMDB01163
is: SBO:0000247
constant: false

metaR HDCAtr
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#

metaR HS2ly
is version of: http://identifiers.org/ec-code/3.10.1.1
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110034#

metaM trdrd m
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:15967

http://identifiers.org/biomodels.db/MODEL1310110034#_b7fc3de5_6633_4d87_b5be_0d68c30f4fc8
is: SBO:0000252
is: Q8N4A0
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: GALNT4
initial amount: NaN
is encoded by: hsa:8693

metaM arachd x
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB01043
name: arachidonate
is: CHEBI:32395

metaR r1786
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
reversible: true

metaM glc D e
boundary condition: false
name: D-glucose
type: Species
is: CHEBI:4167
initial amount: NaN
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR TSTSTERONEt
name: Testosterone transport
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
product: MODEL1310110034#
reversible: true

metaM e4p c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16897
is: C00279
name: D-Erythrose 4-phosphate
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
constant: false
is: HMDB01321
type: Species
has only substance units: false

metaR MI34PP
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
name: inositol-3,4-bisphosphate 4-phosphatase
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.66
product: MODEL1310110034#
type: Reaction

metaR r1560
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_a9619dd6_5f66_4aeb_9c60_220969475f2e
is: SBO:0000252
is encoded by: hsa:4720
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: NDUFS2
is: B7Z792
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0710523d_5bc4_4968_8788_535187bfe2f7
initial concentration: NaN
is encoded by: hsa:5141
is: P27815
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: PDE4A
type: Species
is: SBO:0000252

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c73ce15c_d51c_49b8_94e1_54f81c7e8fc1
initial concentration: NaN
name: _AA278423_1_c
has only substance units: false
constant: false
is encoded by: hsa:AA278423
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_4218dd06_5cfc_45ed_8b0e_269d34a27d6c
constant: false
initial concentration: NaN
initial amount: NaN
name: COX1
is encoded by: hsa:4512
is: SBO:0000252
type: Species
is: Q7GXY8
boundary condition: true
has only substance units: false

metaM acrn m
name: O-acetylcarnitine
is: CHEBI:57589
is: SBO:0000247
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_3551523f_4b0b_40f2_9cde_4a5fe3261ce6
has only substance units: false
initial amount: NaN
is: Q9NY64
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:29988
initial concentration: NaN
name: SLC2A8
boundary condition: true

metaM HC01496 m
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
is: CHEBI:28095
has only substance units: false
type: Species
name: 2-Amino-3-oxoadipate
initial concentration: 1.0

metaR r1453
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#

metaM sebcoa c
boundary condition: false
constant: false
name: sebacoylcoa
initial amount: NaN
initial concentration: 1.0
is: HMDB00651
type: Species
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
is: SBO:0000247

metaM nadp m
constant: false
initial concentration: 1.0
is: HMDB00217
initial amount: NaN
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58349
is: C00006
name: Nicotinamide adenine dinucleotide phosphate

metaM spmd e
is: CHEBI:57834
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: Spermidine
type: Species
initial amount: NaN
is: HMDB01257
is: C00315

metaR AMANK
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110034#
reversible: false
name: N-acetyl-D-mannosamine kinase
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.59

metaR r1679
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110034#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaM hdd2coa c
initial concentration: 1.0
has only substance units: false
is: CHEBI:61526
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB03945
boundary condition: false

metaM CE1617 r
is: SBO:0000247
name: 9-cis-retinoate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
is: CHEBI:17898
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01358
type: Species

metaM oaa c
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
name: Oxaloacetate
has only substance units: false
is: CHEBI:3338
is: C00036
initial concentration: 1.0
is: HMDB00223
is: SBO:0000247
type: Species

metaR TCYNTt
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
product: MODEL1310110034#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR C4CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_d8cd4c3c_da9b_4394_b5de_d0cb7a73f13b
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:D87002
name: _D87002_1_m
type: Species
initial amount: NaN
is: SBO:0000252

metaM dcmp c
name: dCMP
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57566
is: C00239
constant: false
initial concentration: 1.0

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_19ffbd08_ce59_4353_bec0_4c94b421b0cd
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _U37519_1_c
constant: false
is encoded by: hsa:U37519
initial concentration: NaN

metaR r1676
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM nadh c
constant: false
is: SBO:0000247
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
type: Species
initial concentration: 1.0
boundary condition: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial amount: NaN
has only substance units: false

metaM c8dc c
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C15H26NO6 CHARGE: -1
is: C02838
is: HMDB00791
boundary condition: false
type: Species
initial amount: NaN
name: suberyl carnitine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_cd522f67_78bf_493d_a7dc_61877408f7b0
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:130752
constant: false
is: SBO:0000252
has only substance units: false
is: Q5I0G3
boundary condition: true
type: Species
name: MDH1B

metaR CPPPGO
reactant: MODEL1310110034#
fast: false
name: coproporphyrinogen oxidase (O2 required)
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.3
is: SBO:0000176
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000304
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_496173a2_c8fb_4b19_8386_a16bf0164739
initial amount: NaN
name: ST6GALNAC3
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:256435
has only substance units: false
is: Q8NDV1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_e23169b6_f4d6_41ea_82b1_a65749c99300
is encoded by: hsa:56606
constant: false
initial concentration: NaN
name: SLC2A9
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_88fd69fc_b487_4a1d_b1b7_8a5fc9d51ca1
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000297
constant: false
is encoded by: hsa:4830
name: NME1:NME2
initial amount: NaN

metaR r0517
fast: false
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
fast: false
name: RE1903
product: MODEL1310110034#
reversible: true
is: SBO:0000176

metaR r1677
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110034#

metaR PI45P3K
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
fast: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase

metaM nadp r
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
initial concentration: 1.0
is: CHEBI:58349

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM dhcholestanate x
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
is: HMDB00359
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM fdp c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
type: Species
is: C00354
is: CHEBI:16905
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01058
has only substance units: false
name: D-Fructose 1,6-bisphosphate
boundary condition: false

metaR r0512
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#

metaR r2508
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110034#
reversible: true
fast: false
product: MODEL1310110034#
is: SBO:0000185

metaR NADtx
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000134
reversible: true
name: transport of NAD into peroxisome

metaR ADK3m
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110034#
name: adentylate kinase (GTP)
fast: false

metaR DAG HSter
product: MODEL1310110034#
fast: false
name: diacylglycerol ER export
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110034#
type: Reaction

metaM acrn r
name: O-acetylcarnitine
is: HMDB00201
initial amount: NaN
boundary condition: false
is: CHEBI:57589
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
type: Species
initial concentration: 1.0

metaR 3MOX4HOXPGALDOX NADP
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110034#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
product: MODEL1310110034#
fast: false
reversible: true
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110034#_727576c3_5c03_47e5_9d83_642251f4f90c
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:8801
type: Species
name: SUCLG2:SUCLG1
is encoded by: hsa:8802
boundary condition: true
has part: P53597
has only substance units: false
has part: Q96I99

http://identifiers.org/biomodels.db/MODEL1310110034#_6c982588_5983_4da3_996c_f114430c2241
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:23236
is: SBO:0000252
boundary condition: true
name: PLCB1

metaR r0157
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#

metaR COAtm
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
name: CoA transporter

http://identifiers.org/biomodels.db/MODEL1310110034#_9e1efe3d_df3e_40c1_96be_dc27435b1aab
boundary condition: true
type: Species
constant: false
is: P22352
has only substance units: false
is encoded by: hsa:2878
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GPX3

metaM gullac c
is: CHEBI:17587
initial amount: NaN
type: Species
is: HMDB03466
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
name: L-gulono-1,4-lactone
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_a6cb0250_5f9e_45be_b5d1_2d42aa9b0f6d
has only substance units: false
is: Q01959
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6531
constant: false
boundary condition: true
name: SLC6A3
type: Species

metaR FAS140COA
product: MODEL1310110034#
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C14:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110034#

metaR IDOAASE4ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
product: MODEL1310110034#

metaR r2507
name: Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
reversible: true

metaR NS26T2g
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
kinetic law: MODEL1310110034#
fast: false
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.3
is described by: ECO:0000000

metaM m2gacpail hs r
initial concentration: 1.0
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: CHEBI:16038
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
initial amount: NaN

metaM nmn n
boundary condition: false
is: CHEBI:14649
type: Species
initial amount: NaN
name: NMN(-)
is: HMDB00229
initial concentration: 1.0
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_58ab9f4f_499e_492a_9081_8d3ca4f5bc0d
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4709
boundary condition: true
is: Q6IB80
has only substance units: false
name: NDUFB3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_975da772_cd87_4c4c_8089_5db0cb2a6201
is encoded by: hsa:6697
is: P35270
initial amount: NaN
name: SPR
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR XOL27OHtm
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110034#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110034#

metaR COAtn
reactant: MODEL1310110034#
name: coenzyme A transport, nuclear
reversible: true
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000

metaR r0156
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110034#

metaM ksi deg19 l
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
constant: false
name: keratan sulfate I, degradation product 19
is: HMDB00812
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953

metaM xol27oh m
boundary condition: false
constant: false
name: 26-hydroxycholesterol
initial concentration: 1.0
type: Species
is: HMDB02103
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r0514
is described by: ECO:0000000
product: MODEL1310110034#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false
modifier: MODEL1310110034#
type: Reaction
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000176

metaR NDP7g
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

metaR GLYOX
name: hydroxyacylglutathione hydrolase
is version of: http://identifiers.org/ec-code/3.1.2.6
fast: false
product: MODEL1310110034#
type: Reaction
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
modifier: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_823f3ba6_945d_4eca_85d3_9d1520cda4f9
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: NME6
is: O75414
is encoded by: hsa:10201
constant: false
initial amount: NaN
has only substance units: false

metaM spmd c
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0
is: CHEBI:57834
is: SBO:0000247
name: Spermidine
constant: false
initial amount: NaN
type: Species
is: HMDB01257
is: C00315
has only substance units: false

metaR r2509
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
name: Utilized transport
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_eb7057ee_078c_41af_be38_e2dde842168d
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _AA532636_1_m
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AA532636

metaR GAL3ST11
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.8.2.11
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000176
name: Galactosylceramide sulfotransferase

metaR RE1807M
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110034#
name: RE1807
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
reversible: true
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d4d42c68_4ffd_48cb_83bb_dac9a4d1caec
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: Q8N1Q1
name: CA13
is: SBO:0000252
is encoded by: hsa:377677
has only substance units: false
boundary condition: true

metaM btamp m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:3110
constant: false
boundary condition: false
is: HMDB04220
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false

metaM c81crn c
has only substance units: false
name: octenoyl carnitine
constant: false
boundary condition: false
is: HMDB13324
initial amount: NaN
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR r0660
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110034#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
kinetic law: MODEL1310110034#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#

metaR r1671
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
fast: false
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_a9258928_c11b_4b96_b86d_66a6be5ffebb
type: Species
initial concentration: NaN
is: Q9NQR4
is: SBO:0000252
boundary condition: true
name: NIT2
initial amount: NaN
is encoded by: hsa:56954
has only substance units: false
constant: false

metaM gal c
type: Species
has only substance units: false
name: D-Galactose
constant: false
initial amount: NaN
is: C00124
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f12d5b04_f38e_489d_b22d_0522d5da2f5e
is: Q9H5J4
name: ELOVL6
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79071
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_e4703d4b_1c6a_4984_9a4c_f3ef437e6fc8
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_c
constant: false

metaR GALASE9ly
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110034#
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d2d20205_6285_46d2_a8c0_e1f5c9cd7936
is: P31645
name: SLC6A4
initial concentration: NaN
is encoded by: hsa:6532
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM dcacoa x
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
is: C05274
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
initial concentration: 1.0

metaR GLRASE
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: glucuronolactone reductase
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD

metaR COAtp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110034#
name: coenzyme A transport, peroxisomal
reversible: true
fast: false
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR r1670
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_442dedd8_e4a7_4409_ba74_2dab195a5293
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8803
type: Species
constant: false
name: SUCLA2
initial concentration: NaN
is: E5KS60

metaR r0661
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9333dcd7_f741_4c09_973d_5e01cff7c958
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O00459
is encoded by: hsa:5296
is: SBO:0000252
initial amount: NaN
name: PIK3R2
type: Species

metaR GLYt7 211 r
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110034#
is: SBO:0000185
reversible: true
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false

metaR PYDXtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
reversible: true
name: Pyridoxal transport
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_bb4c5495_210f_4fdd_ad3d_481ffa746e2f
constant: false
is: SBO:0000252
is: P15328
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:2348
name: FOLR1
has only substance units: false

metaR B3GALT41g
reversible: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 4
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.62

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
constant: false
is: CHEBI:28938
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: Ammonium
has only substance units: false
is: HMDB00051
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_86a68568_602a_4091_8a56_85de386005e7
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q9BWD1
name: ACAT2
is encoded by: hsa:39

metaM c81crn e
is: HMDB13324
initial amount: NaN
name: octenoyl carnitine
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c4bedb95_e7e6_46ce_a0a6_18a052bb95d2
is: Q8IZV5
type: Species
initial concentration: NaN
boundary condition: true
name: RDH10
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:157506

metaR r1459
name: Transport reaction
reactant: MODEL1310110034#
fast: false
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_89f02fce_f5b2_439f_a611_d762d30ccb54
is encoded by: hsa:8604
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: SLC25A12
is: O75746
boundary condition: true
initial amount: NaN

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM 2mcit e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00379
constant: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
type: Species
is: CHEBI:15598
name: 2-methylcitrate(3-)
initial amount: NaN
is: SBO:0000247

metaM lnlccrn c
name: Linoleyl carnitine
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_773f18df_0ca7_4847_9a9f_dc9a752145da
name: SLC25A1
is: D9HTE9
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6576

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c3cfe7c9_d204_4506_b279_927f8dbeb5c7
is encoded by: hsa:206358
constant: false
has only substance units: false
boundary condition: true
is: Q1LZ56
is: SBO:0000252
name: SLC36A1
initial amount: NaN
type: Species
initial concentration: NaN

metaM gal e
initial amount: NaN
is: HMDB00143
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
boundary condition: false
is: C00124
name: D-Galactose
is: CHEBI:0
is: SBO:0000247
has only substance units: false

metaM 44mzym r
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: HMDB01286
constant: false
name: 14-demethyllanosterol
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:18364
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_338d5704_5f49_4c79_ac46_f50d3cd46082
has only substance units: false
boundary condition: true
name: _AA203143_1_c
initial amount: NaN
is encoded by: hsa:AA203143
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e9ef2330_9f13_4aa2_8ccc_7747bc18d9d2
type: Species
initial concentration: NaN
is: SBO:0000252
is: O43451
constant: false
name: MGAM
initial amount: NaN
is encoded by: hsa:8972
boundary condition: true
has only substance units: false

metaM acrn c
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
name: O-acetylcarnitine
is: CHEBI:57589
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR NACHEX24ly
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR COAtr
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
name: COA transporter, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR RE3568C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: RE3568
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_e83b3f5a_1222_415f_b5c6_50aa625dfdf3
type: Species
is: SBO:0000252
is: B3KT19
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
has only substance units: false
initial amount: NaN
name: PIK3R1
constant: false

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM sebcoa x
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
name: sebacoylcoa
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110034#_52f30888_de5d_4bc8_9796_691ad4815af9
is: SBO:0000252
boundary condition: true
constant: false
is: Q6ZMU0
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ALAD
is encoded by: hsa:210
type: Species

metaM xol27oh r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
name: 26-hydroxycholesterol
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17703
is: HMDB02103

metaR MALSO4tm
reactant: MODEL1310110034#
reversible: true
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
modifier: MODEL1310110034#
name: Malate:sulfate antiport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_f63419cf_9094_4bb1_a725_3aa1c51fdebc
constant: false
initial amount: NaN
has only substance units: false
name: ND4L
is: SBO:0000252
is: Q7GXZ4
is encoded by: hsa:4539
boundary condition: true
type: Species
initial concentration: NaN

metaR GCC2cm
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
reversible: true

metaM cysam c
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58029
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
name: cysteaminium
is: HMDB02991
initial amount: NaN

metaR GGH 10FTHF6GLUe
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110034#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110034#

metaM cs b l
is: SBO:0000247
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: HMDB06202
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_61c63875_b75d_49fb_85cb_fdf1f78fbb79
has only substance units: false
constant: false
is: P51687
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6821
type: Species
name: SUOX

metaR NDPK6n
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is described by: ECO:0000304
reactant: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f9be5cfd_1ab6_42ff_8b62_f79bcd5bfeb7
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P30837
constant: false
initial amount: NaN
is: SBO:0000252
name: ALDH1B1
type: Species
is encoded by: hsa:219

metaM CE2417 m
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28387
has only substance units: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
boundary condition: false
is: SBO:0000247

metaM hom L e
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: L-homoserine
boundary condition: false
has only substance units: false
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
initial concentration: 1.0

metaM subeac c
name: suberic acid
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H12O4 CHARGE: -2
initial amount: NaN
is: HMDB00893
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_54eb6bbc_76bc_4892_8383_97ffce4edeb3
has only substance units: false
name: CA5A
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:763
boundary condition: true
is: P35218
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9cdd2d05_4f13_4d21_a3bf_eaef75024007
constant: false
initial concentration: NaN
name: _AI469183_1_x
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI469183

metaR RNMK
is described by: ECO:0000269
reversible: false
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.22
fast: false
modifier: MODEL1310110034#
name: ribosylnicotinamide kinase
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
kinetic law: MODEL1310110034#

metaR CRNCARtp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110034#
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: carnitine-acetylcarnitine carrier, peroxisomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b84b603a_f915_4b5c_9370_4995289d45ca
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:2235
initial concentration: NaN
is: SBO:0000252
constant: false
name: FECH
has only substance units: false
is: P22830

metaM methf c
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: SBO:0000247
constant: false
is: C00445
boundary condition: false
has only substance units: false
is: HMDB01354
initial concentration: 1.0
type: Species
is: CHEBI:57455
name: 5,10-Methenyltetrahydrofolate

metaR NDPK6m
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000254
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM h2o2 m
is: SBO:0000247
is: C00027
constant: false
initial concentration: 1.0
name: Hydrogen peroxide
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125
is: CHEBI:16240

metaR r0666
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
fast: false
reactant: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.4.2

metaR NDP8ex
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110034#_5ebf906a_0466_452e_9049_5caff5c783ae
is: SBO:0000252
name: PPCDC
is: Q96CD2
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:60490
initial amount: NaN

metaR CYTK2n
reactant: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110034#
name: cytidylate kinase (dCMP),nuclear
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#

metaR CLOHtex2
modifier: MODEL1310110034#
name: chloride transport via hydroxide countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000304
fast: false

metaM h2o2 n
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16240
name: hydrogen peroxide
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2161dfe4_ec0c_40f3_9e26_2b6bb6a7f10d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
type: Species
has only substance units: false
constant: false
name: PANK2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_423d9191_3189_4c61_9de2_34cdfa3dccd3
is: SBO:0000252
name: ENTPD3
has only substance units: false
type: Species
is: O75355
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:956
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_51790188_53df_492f_9bbe_e7d4c2cd28b4
constant: false
initial concentration: NaN
name: PLA2G1B
is: P04054
is encoded by: hsa:5319
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaM CE5132 c
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

http://identifiers.org/biomodels.db/MODEL1310110034#_0511e1ee_9213_4afb_a836_80165e74cf67
initial amount: NaN
name: NT5E
type: Species
is: SBO:0000252
is encoded by: hsa:4907
is: P21589
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM fuc1p L c
name: L-Fucose 1-phosphate
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:28319
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
has only substance units: false

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR KCC2t
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
name: K+-Cl- cotransporter (NH4+)
product: MODEL1310110034#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
modifier: MODEL1310110034#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_8f008c6f_e934_4a04_bac1_de6d50f608bd
initial concentration: NaN
name: SPTLC1
is encoded by: hsa:10558
is: SBO:0000252
type: Species
is: O15269
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaM nh4 m
type: Species
is: C01342
boundary condition: false
is: HMDB00051
is: CHEBI:28938
name: Ammonium
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
constant: false

metaR FUMSO3tm
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR CLS hs
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110034#
name: cardiolipin synthase (homo sapiens)

metaM nmn c
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
initial concentration: 1.0
is: CHEBI:14649
initial amount: NaN
constant: false
is: SBO:0000247
is: C00455
is: HMDB00229
type: Species
name: NMN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5de510da_6664_40de_bbe3_096b81f38ac6
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2954
type: Species
name: GSTZ1
initial concentration: NaN
is: A6NED0
has only substance units: false
is: SBO:0000252

metaM c12dccoa x
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
has only substance units: false
is: SBO:0000247
name: dodecanedioylcoa
constant: false
type: Species
is: HMDB03712
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM ksi deg5 l
boundary condition: false
has only substance units: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 5
constant: false
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
type: Species

metaR r0668
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false

metaR CHSTEROLtrc
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
fast: false
reactant: MODEL1310110034#
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110034#
is: SBO:0000185
name: transport of cholesterol into the cytosol

http://identifiers.org/biomodels.db/MODEL1310110034#_8d8b223b_7be5_4d4a_9c6a_4386e849fb39
is: SBO:0000252
name: PTGS1
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5742
constant: false
is: P23219
initial concentration: NaN
initial amount: NaN

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR NCKt
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reversible: true
kinetic law: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

metaM stcoa c
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
is: CHEBI:57394
is: C00412
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR 2AMACHYD
is: SBO:0000176
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
name: 2-Aminoacrylate hydrolysis
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false
fast: false

metaR r0669
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176
type: Reaction
reversible: false

metaM dtdp c
type: Species
is: C00363
name: dTDP
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
boundary condition: false
initial amount: NaN
constant: false

metaR ICDHyrm
fast: false
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
modifier: MODEL1310110034#
product: MODEL1310110034#
name: Isocitrate dehydrogenase (NADP+)

metaR ACCOAtr
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
reversible: true
is: SBO:0000185
name: acetyl-coa transport
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000

metaM dcacoa m
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: C05274
is: CHEBI:61430
initial concentration: 1.0
constant: false
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

http://identifiers.org/biomodels.db/MODEL1310110034#_0e365922_0278_4bc6_bd81_6ad0dbc189af
boundary condition: true
type: Species
is: P36969
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2879
is: SBO:0000252
name: GPX4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c09c8bc4_66ae_4943_a26c_9eca5a6de49e
is encoded by: hsa:4718
initial concentration: NaN
constant: false
name: NDUFC2
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q549M5

metaM cs d deg4 l
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
initial amount: NaN
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 4
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C31H47NO35S3 CHARGE: -4
type: Species

metaR RE1523M
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: RE1523
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

metaM gullac r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17587
is: HMDB03466
name: L-gulono-1,4-lactone
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1

metaM gal l
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
constant: false
name: D-galactose
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
has only substance units: false
is: HMDB00143

metaM acgam6p c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
constant: false
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247
is: HMDB01062
type: Species
is: CHEBI:57513

metaR DUTPDPn
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110034#
reversible: false
name: dUTP diphosphatase, nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
kinetic law: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f92ad411_6fb4_42b1_9a8e_01309e24ccca
boundary condition: true
name: _728226_1_e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:728226
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR LSTO2r
reversible: false
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176
name: Lathosterol oxidase
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_18f96ee5_b167_4aa0_8421_1dd21112be44
boundary condition: true
initial amount: NaN
is: Q9HCR9
type: Species
initial concentration: NaN
is encoded by: hsa:50940
has only substance units: false
constant: false
is: SBO:0000252
name: PDE11A

metaR C12DCACOT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_909b936d_408c_4550_821f_83039f707363
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q59EA4
initial amount: NaN
type: Species
is encoded by: hsa:5337
boundary condition: true
has only substance units: false
name: PLD1

metaM tetdec2coa c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: HMDB02014
constant: false
type: Species

metaM hom L c
constant: false
type: Species
is: HMDB00719
name: L-homoserine
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM HC02208 c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27696
name: prostaglandin-d1
has only substance units: false
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
constant: false

metaM dtdp e
is: SBO:0000247
is: HMDB01274
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_3c71ce38_fb78_484a_b830_3ada72de39cd
name: GPI
is: SBO:0000252
is: P06744
boundary condition: true
has only substance units: false
is encoded by: hsa:2821
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaM arachd r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:32395
boundary condition: false
is: HMDB01043
name: arachidonate
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

metaM 2mcit c
initial concentration: 1.0
name: 2-methylcitrate(3-)
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:15598
initial amount: NaN
is: HMDB00379
has only substance units: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3

metaR EX ddecrn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b001a0c5_5bd5_49cb_bab1_78acb668d49e
boundary condition: true
is encoded by: hsa:5464
name: PPA1
type: Species
initial amount: NaN
is: Q15181
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR 3MOBte
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110034#
type: Reaction
reversible: true
name: Transport of 3-methyl-2-oxobutanoate
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110034#
fast: false

metaM methf m
constant: false
is: CHEBI:57455
boundary condition: false
initial concentration: 1.0
is: HMDB01354
initial amount: NaN
is: SBO:0000247
name: (6R)-5,10-methenyltetrahydrofolate
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_32b2a090_0639_41a3_b558_1a73b3afdd48
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3028
constant: false
type: Species
has only substance units: false
name: HSD17B10
initial concentration: NaN
initial amount: NaN
is: Q99714

metaR TAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000
name: triacylglycerol transport
fast: false
kinetic law: MODEL1310110034#
reversible: true
type: Reaction
product: MODEL1310110034#

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2fdb161b_d654_4f0d_be2d_bd6176df2f02
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: Q308M7
is encoded by: hsa:5169
is: SBO:0000252
name: ENPP3
has only substance units: false
type: Species

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR BALAtmr
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_fe6f353e_210c_43f9_b8b3_33e57df0f2f6
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AA081045
name: _AA081045_1_c
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_16db0939_527d_409d_86b2_cf290339466a
is: Q9UBF8
has only substance units: false
is encoded by: hsa:5298
initial amount: NaN
name: PI4KB
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM h2o2 c
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB03125
initial amount: NaN
initial concentration: 1.0
name: Hydrogen peroxide
type: Species
constant: false
is: CHEBI:16240

metaR r1569
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02208 e
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin-d1

http://identifiers.org/biomodels.db/MODEL1310110034#_bf78e073_6255_4425_9673_6996bb753e00
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:55650
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: Q9NUD9
name: PIGV

metaR IDOAASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
fast: false
name: alpha-L-iduronidase, lysosomal

metaM g6p c
boundary condition: false
constant: false
is: HMDB01401
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
has only substance units: false
initial amount: NaN
name: D-Glucose 6-phosphate
type: Species
is: CHEBI:61548

metaR GLCAASE8ly
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110034#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000269

metaR ACCOAtn
is described by: ECO:0000000
name: acetyl-CoA transport, nuclear
type: Reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000185

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_99df8a1e_a989_47a0_ac6a_106b38cef5df
initial concentration: NaN
is encoded by: hsa:4712
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: O95139
has only substance units: false
name: NDUFB6
type: Species

metaM nadp c
is: HMDB00217
constant: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
boundary condition: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: CHEBI:58349
initial amount: NaN
initial concentration: 1.0

metaR r1568
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaM xtsn c
constant: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
name: xanthosine
is: CHEBI:18107
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00299

http://identifiers.org/biomodels.db/MODEL1310110034#_b04d3b15_660b_4a87_9755_ac5f3269697d
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: D9HTE9
constant: false
name: SLC25A1
type: Species
initial concentration: NaN
is encoded by: hsa:6576

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
is: HMDB02329
constant: false
type: Species
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
is: SBO:0000247
is: CHEBI:30623
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_1fe9d0f9_24da_4829_8e94_bf2340d25c10
boundary condition: true
type: Species
name: SOD1
initial concentration: NaN
is: P00441
is encoded by: hsa:6647
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_19f9eebb_81ab_4b79_a3cf_a68e7613fd9a
is: A8MYF6
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: MSMO1
is encoded by: hsa:6307
initial amount: NaN
type: Species
boundary condition: true

metaM h2o2 e
constant: false
is: CHEBI:16240
type: Species
name: hydrogen peroxide
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: HMDB03125

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR HISTAtu
is described by: ECO:0000269
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Histamine uniport
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
fast: false

metaR r1567
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_d215b013_a2c5_4ff6_8561_fa2c09e789e6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:LOC728997
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: _LOC728997_1_c

metaR r1109
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
product: MODEL1310110034#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is: SBO:0000176

metaR MI134PP
type: Reaction
modifier: MODEL1310110034#
name: inositol-1,3,4-trisphosphate 1-phosphatase
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.57

http://identifiers.org/biomodels.db/MODEL1310110034#_fc397096_bbb3_40a4_afc2_5d3f5dbb0228
is: P30048
name: PRDX3
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:10935
has only substance units: false

metaR VLCSp
reversible: false
type: Reaction
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110034#
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaM ksi deg13 l
has only substance units: false
is: HMDB00812
initial concentration: 1.0
is: CHEBI:16953
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
name: keratan sulfate I, degradation product 13
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_ab80b221_b554_474b_884b_2de35fb1f7e5
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
is: Q9Y2B2
name: PIGL
initial amount: NaN
is encoded by: hsa:9487

metaR r0522
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
fast: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
type: Reaction
kinetic law: MODEL1310110034#

metaR FORtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
name: FOR transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110034#_8e67490a_19d1_4144_b4a6_8a9ef9f3b171
is: O15496
has only substance units: false
initial amount: NaN
is encoded by: hsa:8399
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PLA2G10
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_36e86e98_6841_4096_8918_b200c55670dd
initial concentration: NaN
is encoded by: hsa:6785
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: ELOVL4
has only substance units: false
is: Q9GZR5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_97efa0fd_8ba5_456d_9c30_f3ce31356e0b
has only substance units: false
name: HLCS
is encoded by: hsa:3141
is: P50747
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9424c42d_24d7_4ccc_b49d_61edcc888400
is: SBO:0000252
is encoded by: hsa:5335
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: PLCG1
constant: false
is: Q9UFY1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_66997e4c_1b6b_4a8f_a31e_8cb268b60a3c
name: ALDH7A1
boundary condition: true
is: E7EPT3
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:501

metaR NDP10ex
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110034#
fast: false
name: nucleoside-diphosphatase (IDP), extracellular
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT

metaM ksi deg41 l
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 41
is: HMDB00143
notes: FORMULA: C34H58N2O26 CHARGE: 0
constant: false
is: CHEBI:12936
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR NADS2
modifier: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.1
product: MODEL1310110034#
name: NAD synthase (glutamine-hydrolysing)
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaM cspg e l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: HMDB06202

http://identifiers.org/biomodels.db/MODEL1310110034#_5632cebd_41c3_41ff_9427_7c48d3b3942c
has only substance units: false
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000297
has part: P37287
is encoded by: hsa:5277
is encoded by: hsa:8818
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_b4f48809_f980_4ded_bae0_093a7efa9a69
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:4704
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: NDUFA9
is: Q16795

metaM c12dc c
boundary condition: false
initial concentration: 1.0
name: dodecanedioyl carnitine
constant: false
has only substance units: false
is: HMDB00623
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species

metaM adn c
is: CHEBI:16335
type: Species
is: HMDB00050
initial amount: NaN
name: Adenosine
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00212

metaR ARABR
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110034#
type: Reaction
reversible: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
name: arabinose reductase

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_3dd1db39_ef50_4493_829d_39482c93b853
type: Species
is encoded by: hsa:AI291895
initial concentration: NaN
name: _AI291895_1_c
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM man6p c
boundary condition: false
is: HMDB01078
initial amount: NaN
type: Species
name: D-Mannose 6-phosphate
has only substance units: false
is: CHEBI:17369
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275

metaR r0276
fast: false
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaM nac e
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false
is: CHEBI:0
boundary condition: false
name: Nicotinate
is: HMDB01488
is: C00253
is: SBO:0000247

metaR r1552
fast: false
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ADNtm
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
name: adenosine facilated transport in mitochondria
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110034#

metaR r1553
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185

metaR PItn
reactant: MODEL1310110034#
name: phosphate transport, nuclear
is: SBO:0000185
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110034#

metaR SR5AR2r
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000176
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6715.1) or (6716.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ
is version of: http://identifiers.org/ec-code/1.3.99.5

metaM Lkynr c
has only substance units: false
name: L-kynurenine
initial amount: NaN
is: HMDB00684
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16946

metaM T antigen g
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:22783
name: T antigen (core 1)

metaR r0166
reactant: MODEL1310110034#
fast: false
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110034#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_19141e5b_5b90_4562_831b_95a68f3fe43a
initial amount: NaN
is: O94778
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:343
constant: false
type: Species
name: AQP8
has only substance units: false

metaR FAS160COA
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110034#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_32cf5241_fc82_46da_b70f_6584d20e5941
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4967
is: Q02218
constant: false
has only substance units: false
name: OGDH
initial concentration: NaN
type: Species

metaM Rtotalcoa c
name: R total Coenzyme A
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
constant: false
type: Species
boundary condition: false
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16189
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_ef10e395_2a87_4bfb_89f5_d9a8c275d281
initial concentration: NaN
has only substance units: false
is: P31040
constant: false
name: SDHA
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6389
is: SBO:0000252

metaR r2193
type: Reaction
product: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110034#

metaM 3hddcoa m
boundary condition: false
is: SBO:0000247
is: HMDB02014
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species
initial amount: NaN

metaR HPYRRy
is: SBO:0000176
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
product: MODEL1310110034#
name: Hydroxypyruvate reductase (NADPH)
is described by: ECO:0000269
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
fast: false

metaM nh4 e
is: CHEBI:28938
constant: false
initial amount: NaN
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: SBO:0000247
is: HMDB00051
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR PI45P4P
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
type: Reaction
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false

metaR CERT2rt
fast: false
reversible: true
modifier: MODEL1310110034#
product: MODEL1310110034#
name: ceramide transport protein
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaM adn e
is: CHEBI:16335
type: Species
is: HMDB00050
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
name: Adenosine
is: C00212
initial concentration: 1.0
has only substance units: false

metaM btcoa c
is: CHEBI:57371
constant: false
is: HMDB01088
has only substance units: false
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00136

metaR DHCRD2
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
is described by: ECO:0000269
product: MODEL1310110034#
fast: false
name: dihydroceramide desaturase
is: SBO:0000176
reactant: MODEL1310110034#

metaR r1554
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110034#

metaR XAO2x
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:18538891,PMID:18538892 NOTES:IT EC 1.17.3.2. Thought to have a role in conversion of purine to allantoin which may not be relevant in humans
name: xanthine oxidase
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: false

metaM nac c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
boundary condition: false
is: CHEBI:0
name: Nicotinate
is: HMDB01488
is: C00253

http://identifiers.org/biomodels.db/MODEL1310110034#_56436122_040b_4211_9103_a90af0a71f3c
initial amount: NaN
is: Q53XN1
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:1351
name: COX8A

metaM 5HPET c
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: HMDB01193
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57450
name: 5(S)-HPETE(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_07296fd1_3c63_414e_835e_7dcfdbcd65a5
constant: false
name: SLC3A2
is: SBO:0000252
is encoded by: hsa:6520
initial amount: NaN
initial concentration: NaN
is: P08195
boundary condition: true
has only substance units: false
type: Species

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
name: L-aspartate(1-)
is: HMDB00191
is: CHEBI:29991
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaM dudp n
type: Species
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
name: dUDP(3-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:60471
initial concentration: 1.0
has only substance units: false

metaR PI4PLCn
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
modifier: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
reactant: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110034#_94eb638a_8e13_47cb_b3b8_2644975db248
boundary condition: true
initial concentration: NaN
type: Species
is: P11310
initial amount: NaN
is encoded by: hsa:34
name: ACADM
has only substance units: false
constant: false
is: SBO:0000252

metaM hs l
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: heparan sulfate, free chain
is: CHEBI:28815
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r0160
is version of: http://identifiers.org/ec-code/2.1.3.2
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
fast: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_c090b146_16e3_4dd6_8018_258117d44d49
type: Species
is encoded by: hsa:4830
is: SBO:0000297
initial amount: NaN
has only substance units: false
name: NME1:NME2
boundary condition: true
initial concentration: NaN
constant: false

metaM udpacgal c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57847
type: Species
has only substance units: false
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
is: HMDB00304

metaM oaa x
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
name: Oxaloacetate
is: HMDB00223
type: Species
initial amount: NaN
is: CHEBI:16452
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00036

metaR BTNPL
fast: false
is described by: ECO:0000000
name: holocarboxylase synthestase (biotin protein ligase)
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.3.4.10
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
product: MODEL1310110034#

metaR DOLMANP Uter
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (uterus)
is: SBO:0000185

metaR DCK1n
kinetic law: MODEL1310110034#
name: Deoxycytidine kinase, nuclear (ATP)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.74
fast: false
reversible: true
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

http://identifiers.org/biomodels.db/MODEL1310110034#_c864276f_f9bf_4701_b783_7335f12746b2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4190
is: SBO:0000252
type: Species
is: B7Z3I7
initial amount: NaN
name: MDH1
has only substance units: false

metaM dgdp m
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dGDP(2-)
initial amount: NaN
is: CHEBI:58595
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: HMDB00960

metaR ALASm
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
name: 5-aminolevulinate synthase
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.37
reversible: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_cf50fdd1_ca4d_4c58_b62d_06c3fc98129c
is encoded by: hsa:250
constant: false
name: ALPP
initial concentration: NaN
is: P05187
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_8c2fb3ba_8fe0_4b4a_b789_71bd272fad45
is encoded by: hsa:9197
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: O00400
boundary condition: true
is: SBO:0000252
name: SLC33A1

metaM btamp c
is: SBO:0000247
is: CHEBI:3110
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
name: Biotinyl-5'-AMP
boundary condition: false
initial amount: NaN
is: HMDB04220
constant: false
initial concentration: 1.0

metaM tyr L c
is: HMDB00158
initial concentration: 1.0
has only substance units: false
is: CHEBI:17895
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
name: L-tyrosine
initial amount: NaN
is: SBO:0000247
type: Species

metaM asp L c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
name: L-aspartate(1-)
initial amount: NaN
is: HMDB00191
has only substance units: false
initial concentration: 1.0
is: CHEBI:29991
boundary condition: false
is: SBO:0000247
constant: false

metaM CE2421 m
type: Species
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
boundary condition: false
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
constant: false
is: CHEBI:30623
is: HMDB02329
initial amount: NaN
is: SBO:0000247

metaR r0809
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
reversible: true

metaM xol7aone c
is: CHEBI:17899
is: HMDB01993
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
initial concentration: 1.0

metaM dgdp n
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58595
boundary condition: false
is: SBO:0000247
name: dGDP(2-)

metaR XAOx
is described by: ECO:0000269
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110034#
is: SBO:0000176
name: xanthine oxidase,peroxisomal
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:IT (1.17.3.2)
reversible: false
fast: false
product: MODEL1310110034#

metaM udpacgal g
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57847
constant: false
boundary condition: false
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110034#_5bd8c164_0661_46b2_bfde_12ef83bd6478
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q5MY95
name: ENTPD8
is: SBO:0000252
is encoded by: hsa:377841

metaM HC00591 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16769
constant: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
is: SBO:0000247

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_8d8d8d42_726b_4218_a22d_c7965099bfbd
type: Species
is: O00750
initial amount: NaN
is: SBO:0000252
name: PIK3C2B
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5287
constant: false
has only substance units: false

metaR r1776
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaR RE3245C
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reactant: MODEL1310110034#
type: Reaction
name: RE3245
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_33c86da5_ad9d_4596_9bd3_16a2570120c8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: FOLR1
constant: false

metaR SUCCt2m
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000185
reversible: true
name: succinate transport, mitochondrial
product: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110034#
fast: false

metaM dolp U r
boundary condition: false
is: CHEBI:57683
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: dolichyl phosphate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_82618201_9a85_41b7_9365_c1805ee57438
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5136
has only substance units: false
constant: false
boundary condition: true
is: P54750
name: PDE1A
initial amount: NaN

metaR EX c4crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM c8dc x
is: HMDB00893
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
name: suberyl carnitine
initial amount: NaN
type: Species
has only substance units: false

metaM h c
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:24636
type: Species
name: proton

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_4868d8b6_6744_4495_8ebe_1f07ac6ffecb
is: SBO:0000252
name: SULT1A1
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6817
initial amount: NaN

metaR r1664
product: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true

metaM lnlccrn m
has only substance units: false
boundary condition: false
name: Linoleyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
is: HMDB06469
is: SBO:0000247
constant: false

metaR PHCDm
is described by: ECO:0000304
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_b25576b8_064b_4495_bf65_f9ff4e6d048a
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:197257
name: LDHD
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR ACNAMtn
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
name: N-acetylneuraminate nuclear import
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_914d9768_5efe_43aa_896f_b5ba781faaa8
is encoded by: hsa:4541
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q7GXZ1
has only substance units: false
type: Species
initial concentration: NaN
name: ND6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_3ce3bc0d_a16e_4e95_aef9_81099dbd935f
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3633
is: P32019
name: INPP5B

metaM dhcrm hs c
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
boundary condition: false
name: dihydroceramide
is: CHEBI:31488
initial amount: NaN

metaM 1p3h5c m
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate

metaM r1p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
name: alpha-D-Ribose 1-phosphate
is: C00442
boundary condition: false
is: HMDB01489
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57720
initial concentration: 1.0
has only substance units: false
type: Species

metaR r2199
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r1665
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110034#
reversible: true
fast: false

metaM Lpipecol x
is: SBO:0000247
initial amount: NaN
is: CHEBI:30913
type: Species
constant: false
has only substance units: false
is: HMDB00716
boundary condition: false
name: L-pipecolic acid
initial concentration: 1.0
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

metaR NADH2 u10m
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
name: NADH dehydrogenase, mitochondrial
kinetic law: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000134
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#

metaM lald L c
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (S)-lactaldehyde
initial concentration: 1.0
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
constant: false
initial amount: NaN
is: CHEBI:18041
type: Species

metaM 3hddcoa c
boundary condition: false
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
is: HMDB00623
constant: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR ADPACDAc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r1666
type: Reaction
name: Y+LAT2 Utilized transport
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000000

metaM lac D c
is: HMDB01311
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16004
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
type: Species
name: (R)-lactate

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16038
name: phosphatidylethanolamine
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR SBCOAACOTx
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_78181ebe_6fce_418d_a7a8_65a82f6aa8c4
constant: false
has only substance units: false
is encoded by: hsa:2629
name: GBA
boundary condition: true
is: B7Z5G2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaM cspg e e
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
is: CHEBI:16040
has only substance units: false
initial amount: NaN
is: HMDB00630
boundary condition: false
type: Species
constant: false

metaR PROSTGE2t
is described by: ECO:0000269
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
modifier: MODEL1310110034#
fast: false
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true

metaM tyr L e
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17895
has only substance units: false
is: HMDB00158
name: L-tyrosine
initial amount: NaN

metaR RTOTAL3FATPc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b5dfecf4_8ddc_4b1c_9c62_b0246c76faf9
is encoded by: hsa:AA081045
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: _AA081045_1_e
initial concentration: NaN
constant: false

metaR RE3556C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
name: RE3556
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#

metaM adn m
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
is: SBO:0000247
is: CHEBI:16335
type: Species
initial amount: NaN
boundary condition: false
name: adenosine
is: HMDB00050
constant: false

metaR PItg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is described by: ECO:0000000
name: phosphate transport, Golgi apparatus
type: Reaction

metaR r1667
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
name: Y+LAT2 Utilized transport
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_9a6f788a_66a4_4082_b055_8f6358d63061
constant: false
boundary condition: true
type: Species
name: PISD
is: SBO:0000252
has only substance units: false
is: Q9UG56
initial concentration: NaN
is encoded by: hsa:23761
initial amount: NaN

metaM dudp m
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471
initial amount: NaN
name: dUDP(3-)
initial concentration: 1.0
is: HMDB01000
boundary condition: false

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
product: MODEL1310110034#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#

metaR CYTK11n
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
is: SBO:0000176
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_b1b61662_00d8_44e4_ba07_0759d21eb5b8
is encoded by: hsa:64077
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q9H008
initial concentration: NaN
name: LHPP
constant: false
has only substance units: false

metaM sbt D e
initial amount: NaN
name: D-glucitol
is: HMDB00247
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_d06b9994_4e67_4048_b034_ede8fbdf805a
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: VNN3
initial amount: NaN
is encoded by: hsa:55350
constant: false
type: Species

metaM Asn X Ser Thr l
is: CHEBI:28938
constant: false
boundary condition: false
has only substance units: false
type: Species
is: C01342
initial concentration: 1.0
is: HMDB00051
initial amount: NaN
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110034#_dab042c6_9fc6_4cb9_aca3_91ee83311764
is: SBO:0000252
name: SLC7A6
constant: false
initial concentration: NaN
is: Q92536
has only substance units: false
initial amount: NaN
is encoded by: hsa:9057
boundary condition: true
type: Species

metaM HC00591 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
initial amount: NaN
name: 2-oxoglutaramate
boundary condition: false
constant: false
is: CHEBI:16769

http://identifiers.org/biomodels.db/MODEL1310110034#_f1ae99d8_d942_42ba_b1fe_71d72588f605
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:30
name: ACAA1
constant: false
boundary condition: true
is: Q96CA6
is: SBO:0000252
initial concentration: NaN

metaR KAS8
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: b-ketoacyl synthetase (palmitate, n-C16:0)
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
reactant: MODEL1310110034#
fast: false

metaR r2196
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_e48a1c9a_edce_4c04_b6f5_e28f754e308b
name: SLC26A6
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:65010
type: Species
is: Q9Y3Y1

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r1668
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false

metaR r0670
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_2d0613f8_85f2_4783_badd_982d9a4d29b1
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P36551
is encoded by: hsa:1371
initial amount: NaN
is: SBO:0000252
name: CPOX
initial concentration: NaN

metaR r1443
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110034#
reversible: false
name: EC:1.3.3.6
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: C01342
is: HMDB00051
name: Ammonium
constant: false
boundary condition: false
is: CHEBI:28938
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaM udpacgal l
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57847
is: HMDB00304
initial amount: NaN
boundary condition: false

metaM ppi c
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:0
is: HMDB00250
initial amount: NaN
name: Diphosphate
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_50628d37_f48a_43f0_9b40_41c54121f961
is: P28330
is encoded by: hsa:33
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: ACADL
boundary condition: true
type: Species
initial concentration: NaN

metaR RE0512M
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110034#
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_92c7de85_b21b_4d43_90f6_5b70b6048fe3
initial concentration: NaN
is: Q8TCD5
is encoded by: hsa:30833
name: NT5C
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_34469af6_c614_4ca5_a452_9dcef9a4d978
is encoded by: hsa:8802
type: Species
boundary condition: true
constant: false
is: P53597
initial concentration: NaN
name: SUCLG1
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR C8DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR 34HPPOR
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reversible: false
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#

metaM sbt D c
is: HMDB00247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17924
type: Species
boundary condition: false
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110034#_a652133d_5beb_4446_afd2_e91ae6b4bfad
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9H6Y6
type: Species
name: MYO5B
is encoded by: hsa:4645
initial concentration: NaN
constant: false

metaR r2195
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185

metaM strch2 e
is: CHEBI:4167
notes: FORMULA: C18H32O16 CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00122
type: Species
is: SBO:0000247
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})

http://identifiers.org/biomodels.db/MODEL1310110034#_004cb329_9eb0_4e89_bcb9_b78572ec7b75
constant: false
initial concentration: NaN
is encoded by: hsa:26503
initial amount: NaN
is: Q9NRA2
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC17A5
type: Species

metaR H2Oter
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
name: H2O endoplasmic reticulum transport

metaR r1669
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

metaR r1444
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
name: EC:1.3.3.6
type: Reaction
reactant: MODEL1310110034#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_9eafb509_77a2_4500_8f43_4ba191e41f88
is: Q8N5Z0
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:51166
initial concentration: NaN
name: AADAT
constant: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_3a4bee69_8716_44e3_8717_0b97dcc15397
is: B3KMA6
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACSL3
initial amount: NaN
is encoded by: hsa:2181
type: Species
boundary condition: true
has only substance units: false

metaR PROSTGI2tr
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR r0801
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is described by: ECO:0000000
modifier: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_e5fc3f27_921f_4e1b_a410_d87df427dc42
initial concentration: NaN
is encoded by: hsa:4728
is: SBO:0000252
constant: false
is: O00217
initial amount: NaN
type: Species
name: NDUFS8
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_debe6b1c_b379_46fa_82b4_6ed86924152a
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:197257
boundary condition: true
has only substance units: false
constant: false
is: Q86WU2
is: SBO:0000252
name: LDHD

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_fcf82dce_1c6d_47eb_9378_65d927dac72a
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC8A3
is encoded by: hsa:6547
initial amount: NaN

metaM HC01104 e
has only substance units: false
is: SBO:0000247
is: CHEBI:61146
type: Species
initial amount: NaN
initial concentration: 1.0
name: 4-nitrophenyl phosphate(2-)
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
boundary condition: false

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false

metaM ppi e
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:33019
name: Diphosphate
boundary condition: false
is: HMDB00250
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110034#_ee1ebf9f_a0fb_44f5_87c5_03347bf43f24
constant: false
has part: F8W7V3
is encoded by: hsa:517
is: SBO:0000297
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
type: Species
initial concentration: NaN
is encoded by: hsa:9551
boundary condition: true
has only substance units: false

metaM dcacoa c
is: HMDB06404
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
type: Species
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61430
is: C05274
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2e03f66f_c59c_4b4b_a47d_36708c74d0ba
initial concentration: NaN
is encoded by: hsa:4831
has part: P22392
has only substance units: false
name: NME1:NME2
is: SBO:0000297
constant: false
boundary condition: true
initial amount: NaN
type: Species
has part: P15531
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110034#_1ae667fc_e485_43cc_950f_7bfbe0d71e9e
is encoded by: hsa:65263
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PYCRL
initial amount: NaN
constant: false
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110034#_8cefe054_6cf3_42be_91e2_ea34faa2c19e
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ABAT
boundary condition: true
initial concentration: NaN
is encoded by: hsa:18
is: P80404
type: Species
constant: false

metaM c12dccoa c
initial amount: NaN
constant: false
name: dodecanedioylcoa
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00623
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H51N7O19P3S CHARGE: -5

metaR r0523
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
type: Reaction
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:

metaR BTNPLm
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reactant: MODEL1310110034#

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR r1445
reversible: false
name: EC:1.3.3.6
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR r2197
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110034#
reversible: true
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR URIt5le
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
modifier: MODEL1310110034#
reversible: false
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR DNDPt31m
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via ATP antiport
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_ce8b1963_7d39_4ff2_9288_2c270e8a8dc6
is: SBO:0000252
is: Q96RV2
boundary condition: true
type: Species
is encoded by: hsa:3038
name: HAS3
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR HISCAT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR MAGt
type: Reaction
name: monoacylglycerol 2 transport
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000269
is: SBO:0000185

metaM nadp x
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
constant: false
type: Species
initial amount: NaN
is: HMDB00217
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8a3327b6_8af0_4096_be43_772e6ac95569
has only substance units: false
initial amount: NaN
is encoded by: hsa:2687
boundary condition: true
constant: false
initial concentration: NaN
is: P36269
is: SBO:0000252
type: Species
name: GGT5

metaM dolp U c
has only substance units: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaM HC01118 r
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: presqualene diphosphate(3-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false

metaM dudp c
boundary condition: false
is: C01346
type: Species
constant: false
name: dUDP
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:60471
is: HMDB01000

metaM cs d l
type: Species
is: HMDB06202
initial concentration: 1.0
constant: false
is: SBO:0000247
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), free chain
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r1446
reactant: MODEL1310110034#
type: Reaction
name: EC:1.3.3.6
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_ca2b56c1_616b_4366_bfa8_448c77faf72d
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84532
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q9NUB1
name: ACSS1

metaR GACPAILter
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
fast: false
name: glucosaminyl-acylphosphatidylinositol ER flippase

metaM cs d deg3 l
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C37H54NO41S3 CHARGE: -5
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0

metaR PEPCKm
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
type: Reaction
name: Phosphoenolpyruvate carboxykinase (GTP)
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32

metaR ST8SIA52g
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269

metaM hdd2coa x
initial amount: NaN
type: Species
boundary condition: false
is: HMDB03945
has only substance units: false
is: CHEBI:61526
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
constant: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: SBO:0000247

metaR r0051
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
fast: false
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110034#
type: Reaction
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is: SBO:0000176

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57767
constant: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ab781cb4_903f_416a_a780_f02df1bc1ccb
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:AI539321
name: _AI539321_1_c

metaR 3DSPHR
is described by: ECO:0000269
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.102
is: SBO:0000176
modifier: MODEL1310110034#
fast: false
name: 3-Dehydrosphinganine reductase
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_9f97e1f0_f6d1_44d0_95ac_90d9202e4f1d
type: Species
has only substance units: false
is encoded by: hsa:10786
is: O00476
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC17A3
initial concentration: NaN

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110034#
fast: false
reversible: true
kinetic law: MODEL1310110034#

metaR FAEL183
modifier: MODEL1310110034#
is: SBO:0000176
reversible: false
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C18:3CoA)
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_d1d999c5_eddc_4511_bc9d_630325e57640
boundary condition: true
initial concentration: NaN
name: _AI480132_1_c
is encoded by: hsa:AI480132
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR DGCHOLte
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_851211b5_b911_4b0c_bf65_d443879e6e34
initial amount: NaN
has only substance units: false
name: NDUFB9
is: Q9Y6M9
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4715
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_4b02e8f0_52b2_4648_9e67_7bedead4ecfc
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:509
name: ATP5C1
type: Species
is: P36542
initial amount: NaN
initial concentration: NaN

metaR DNDPt20m
fast: false
is: SBO:0000185
name: dTDP transport via ATP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: false

metaM oaa m
boundary condition: false
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
name: Oxaloacetate
is: C00036
type: Species
constant: false
initial concentration: 1.0
is: HMDB00223
is: SBO:0000247
initial amount: NaN

metaR DAGKn hs
is version of: http://identifiers.org/ec-code/2.7.1.107
kinetic law: MODEL1310110034#
is: SBO:0000176
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
fast: false

metaR CSEPASEly
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110034#
reversible: false
fast: false
is: SBO:0000176

metaR ACACT4p
reversible: false
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
reactant: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD

metaR URIt4
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: uridine transport in via sodium symport
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
fast: false
reversible: false

metaR DOLPMT3 Uer
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110034#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.260

metaM cala c
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
constant: false
type: Species
initial amount: NaN
name: N-carbamoyl-beta-alaninate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:11892
is: HMDB00026

metaR GALASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_73cf1d40_b208_4aa9_ba49_a83ebdb11c9f
type: Species
is encoded by: hsa:622
boundary condition: true
initial amount: NaN
name: BDH1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR FUMSO4tm
type: Reaction
reversible: true
reactant: MODEL1310110034#
is: SBO:0000185
name: Fumarate:sulfate antiport, mitochondrial
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaM pep c
is: SBO:0000247
is: C00074
boundary condition: false
initial concentration: 1.0
is: HMDB00263
constant: false
has only substance units: false
is: CHEBI:18021
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
type: Species

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR ACGAMK
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000269
name: N-acetylglucosamine kinase
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_a24b2551_0d69_48b3_b815_d4c8ebe2e6fe
boundary condition: true
is: Q5HYI4
is: SBO:0000252
is encoded by: hsa:6713
name: SQLE
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR FTHFL
reactant: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110034#
reversible: true
name: Formate-tetrahydrofolate ligase
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR PGISr
type: Reaction
name: Prostaglandin I2 synthase
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
reversible: true
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.3.99.4

http://identifiers.org/biomodels.db/MODEL1310110034#_e51bb530_2e75_470a_842d_462c484ef1c3
initial concentration: NaN
constant: false
type: Species
name: AK5
is: SBO:0000252
is: Q9Y6K8
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:26289

http://identifiers.org/biomodels.db/MODEL1310110034#_f91ccf0e_df5e_461e_b2d2_651e6c243249
boundary condition: true
is encoded by: hsa:5294
initial concentration: NaN
name: HCST:PIK3CG
type: Species
initial amount: NaN
has part: Q9UBK5
is: SBO:0000297
has only substance units: false
is encoded by: hsa:10870
has part: P48736
constant: false

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153

metaM c12dc x
constant: false
initial concentration: 1.0
name: dodecanedioyl carnitine
notes: FORMULA: C19H34NO6 CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02014

metaR C50CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2a74e072_c985_412e_8fa6_b9aa303a6686
is encoded by: hsa:79611
name: ACSS3
initial amount: NaN
has only substance units: false
is: Q9H6R3
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR r1661
reactant: MODEL1310110034#
fast: false
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
modifier: MODEL1310110034#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DOPASULT
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
fast: false
name: Dopamine Sulfotransferase

http://identifiers.org/biomodels.db/MODEL1310110034#_4c2c68a2_f6f0_4ba5_a052_6596e86f9f99
name: PANK4
is: Q9NVE7
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:55229
is: SBO:0000252
boundary condition: true

metaM HC02216 e
is: CHEBI:28922
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110034#_3bbe5c85_5549_4d14_b0cd_4709241e54f4
constant: false
boundary condition: true
is encoded by: hsa:6528
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC5A5
is: Q92911
initial concentration: NaN

metaM dhbpt c
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
is: HMDB00038
name: 6,7-dihydrobiopterin
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR NDPK7n
modifier: MODEL1310110034#
fast: false
reversible: true
is described by: ECO:0000304
product: MODEL1310110034#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM focytC m
boundary condition: false
type: Species
name: Ferrocytochrome C
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928

metaR r0679
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110034#

metaR THP2Ctp
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#

metaR r1660
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
fast: false

metaR BHBt
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
kinetic law: MODEL1310110034#

metaR r0055
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is version of: http://identifiers.org/ec-code/2.4.2.7
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_ef9ff8a3_5d81_4e25_8798_0553d56ac618
type: Species
boundary condition: true
name: HADHA
is: SBO:0000252
has only substance units: false
is: E9KL44
initial concentration: NaN
constant: false
is encoded by: hsa:3030
initial amount: NaN

metaM i c
is: HMDB12238
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: iodide
has only substance units: false
constant: false
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
boundary condition: false

metaR ATP2ter
fast: false
name: AMP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#

metaM pe hs m
has only substance units: false
initial concentration: 1.0
name: phosphatidylethanolamine
boundary condition: false
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM dcdp c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58593
is: C00705
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
name: dCDP
is: HMDB01245
type: Species
constant: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaR r0399
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110034#
product: MODEL1310110034#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
kinetic law: MODEL1310110034#

MODEL1310110034#
species: metaM ksii core4 deg2 l
species: metaM ksi deg30 l
species: metaM gt1alpha hs g
species: metaM ksi deg21 l
species: metaM orot c
species: metaM sl L c
species: metaM mercplac c
species: metaM mag hs c
stoichiometry: 0.392525
species: metaM cmpacna n
species: metaM 10fthf m
stoichiometry: 7.92
species: metaM HC01409 m
species: metaM cspg d l
species: metaM c6dc x
species: metaM ocdcea c
species: metaM dag hs e
species: metaM 3dhguln c
species: metaM gd3 hs g
species: metaM ala B c
species: metaM 4nphsf c
species: metaM pyr x
species: metaM fald c
species: metaM ivcoa c
species: metaM HC02180 e
species: metaM hs deg13 l
species: metaM C02470 c
species: metaM glyc R m
species: metaM o2s m
species: metaM 2dr1p c
species: metaM gtp e
species: metaM hmgcoa x
species: metaM 4mzym int1 r
species: metaM cl c
species: metaM CE2420 m
species: metaM so4 c
species: metaM HC02203 c
species: metaM HC01410 m
species: metaM xol7aone m
species: metaM CE2421 m
species: metaM cl e
species: metaM 4ppcys c
species: metaM pgp hs c
species: metaM ppcoa x
species: metaM hxan e
species: metaM ptth c
species: metaM 12ppd S c
species: metaM 1p3h5c m
species: metaM udp r
species: metaM cs c deg5 l
species: metaM coa r
species: metaM cmp g
species: metaM mn l
species: metaM ksi deg33 l
species: metaM dump c
species: metaM acgam e
species: metaM hexdicoa c
species: metaM dad 2 c
species: metaM ser L c
species: metaM bhb e
species: metaM ppi x
species: metaM ca2 e
species: metaM cspg a e
species: metaM ahcys e
species: metaM dopa e
species: metaM pheme e
species: metaM dag hs c
species: metaM fad c
species: metaM pan4p e
species: metaM fgam c
species: metaM man6p c
species: metaM tcynt e
species: metaM cdp n
species: metaM lys L e
species: metaM ps hs e
species: metaM mercplaccys c
species: metaM tdchola c
species: metaM Rtotal3coa c
species: metaM 3mgcoa m
species: metaM mercplaccys e

metaR SERGLYexR
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR PETOHMm hs
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: phosphatidylethanolamine N-methyltransferase
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.1.1.17
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reversible: false

metaM HC02216 c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: prostaglandin-f2beta
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: SBO:0000247
type: Species

metaR GLNtm
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110034#

metaR r1662
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
fast: false
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_1837da78_dd75_4918_819b_02e07ac2762c
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9UIG8
initial concentration: NaN
name: SLCO3A1
is encoded by: hsa:28232

http://identifiers.org/biomodels.db/MODEL1310110034#_e67e634d_0d6c_49fb_91e7_ea4be7399678
type: Species
name: SLC25A22
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79751
is: Q9H936
constant: false
initial amount: NaN

metaM i e
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial amount: NaN
name: iodide
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16382
constant: false
is: HMDB12238

metaM ksi deg31 l
has only substance units: false
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
boundary condition: false
name: keratan sulfate I, degradation product 31
initial concentration: 1.0
is: CHEBI:16953
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: HMDB00812

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_851ce832_6c91_4c9d_864f_2ea1905b73c7
name: SLC2A6
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:11182
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9UGQ3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_bdb1c53b_f25a_47ff_b866_312eafdfc914
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8394
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q99755
type: Species
name: PIP5K1A

metaR DPMVDc
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is version of: http://identifiers.org/ec-code/4.1.1.33
name: diphosphomevalonate decarboxylase, cytosol
modifier: MODEL1310110034#

metaR THRD L
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is: SBO:0000176
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110034#
reversible: false
name: L-threonine deaminase
is described by: ECO:0000269
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#

metaR r0393
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: false
modifier: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d9253c75_aa8f_42ca_b3d2_a6dd152836c4
is encoded by: hsa:4705
is: SBO:0000252
initial concentration: NaN
constant: false
is: O95299
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: NDUFA10

http://identifiers.org/biomodels.db/MODEL1310110034#_1a44de43_fa2c_4afb_89af_2d83b289739c
is encoded by: hsa:7357
name: UGCG
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q16739
has only substance units: false
boundary condition: true

metaM 4nph c
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 4-nitrophenolate
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
is: CHEBI:57917

metaM nrpphr e
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:33569
name: Norepinephrine
initial concentration: 1.0
initial amount: NaN
is: HMDB00216
is: SBO:0000247

metaR PNTK
type: Reaction
name: pantothenate kinase
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR r0960
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110034#
is: SBO:0000185
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_6553932b_31c7_433e_b689_9a5a4c1f2ef2
is encoded by: hsa:AI697028
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _AI697028_1_m
has only substance units: false

metaM 4nph e
initial concentration: 1.0
is: HMDB01232
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 4-nitrophenolate
constant: false
is: CHEBI:57917
boundary condition: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

http://identifiers.org/biomodels.db/MODEL1310110034#_e5eef9b3_9102_4652_90ef_8e291aab49a6
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5315
initial concentration: NaN
is: P14618
initial amount: NaN
is: SBO:0000252
type: Species
name: PKM2

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
product: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110034#
name: alcohol dehydrogenase (D-1,2-propanediol)
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000

metaR SIAASE2ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000176
name: sialidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR r1559
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PPD2CSPp
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
fast: false
name: PPD2CSPp
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_0ad14982_e3f3_40a6_a92e_9fd3eef300d4
name: GALK2
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2585
has only substance units: false
initial concentration: NaN
constant: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR GPIDA2er
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_8049c420_6cb8_4956_b19e_15f223776dae
constant: false
name: UEVLD
is: Q8IX04
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55293
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_1692477c_b57a_426c_a1fb_607baea1f18c
boundary condition: true
constant: false
is encoded by: hsa:2805
is: P17174
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: GOT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_5cd86220_3125_4784_bf5d_e19887e3212a
is: P32119
is: SBO:0000252
constant: false
name: PRDX2
is encoded by: hsa:7001
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaR LSTO1r
product: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176
name: Lathosterol oxidase
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ

metaM acgpail hs c
initial concentration: 1.0
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57265
constant: false
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110034#_1179c60e_7ae5_41fe_a44c_fba1aa070639
has only substance units: false
is encoded by: hsa:1956
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: P00533
name: EGFR
is: SBO:0000252
initial amount: NaN

metaR PItx
name: Phosphate transporter, peroxisome
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true

metaM 4mzym int2 r
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
boundary condition: false
is: HMDB06838
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: 4-Methylzymosterol intermediate 2

metaM dhcholestanate c
has only substance units: false
boundary condition: false
is: HMDB00359
type: Species
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
is: SBO:0000247
is: CHEBI:16577
initial concentration: 1.0

metaM nrpphr c
initial amount: NaN
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
has only substance units: false
is: HMDB00216
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:33569

metaR r0170
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
reactant: MODEL1310110034#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
reversible: true
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR C81CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaM tym c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false
constant: false
name: tyraminium
initial concentration: 1.0
initial amount: NaN
is: HMDB00306
type: Species
is: CHEBI:327995

http://identifiers.org/biomodels.db/MODEL1310110034#_33f1cb04_915f_49aa_acde_debdcb1a37b0
has only substance units: false
type: Species
is encoded by: hsa:6120
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q53TV9
boundary condition: true
constant: false
name: RPE

metaR EX acgam LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-D-glucosamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e8988152_c306_46b5_bc2a_2cb3af29b16e
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _H53099_1_m
type: Species
constant: false
is encoded by: hsa:H53099
is: SBO:0000252

metaM btcoa m
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: SBO:0000247
constant: false
is: CHEBI:57371
name: Butanoyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00136
boundary condition: false
is: HMDB01088
type: Species

metaR r0962
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: false
is: SBO:0000185
type: Reaction
fast: false
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR EX c101crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c5cfec00_46ab_400b_bc49_0d3e231ebe40
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:517
name: ATP5G2
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR TDCRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_9996b3fa_977e_4098_b70d_fe0e6835822c
is encoded by: hsa:6520
has only substance units: false
constant: false
has part: P08195
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has part: Q9NS82
is encoded by: hsa:56301
name: SLC7A10:SLC3A2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_add92856_322e_4960_8963_3c61606b6a2f
name: INPP5E
boundary condition: true
is encoded by: hsa:56623
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9NRR6
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_9f2f2a85_eb18_412d_9460_2db538d91518
name: HAS2
is encoded by: hsa:3037
is: Q92819
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaM pe hs c
constant: false
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
initial amount: NaN
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species

metaM dcdp n
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: dCDP(3-)
initial concentration: 1.0
is: CHEBI:58593

metaR r0963
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR PSP L
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
name: phosphoserine phosphatase (L-serine)
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
is: SBO:0000176
reactant: MODEL1310110034#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR r1556
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR 3AIBTm
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110034#
name: L-3-aminoisobutyrate transaminase, mitochondrial
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110034#

metaR ST3GAL23g
modifier: MODEL1310110034#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4

http://identifiers.org/biomodels.db/MODEL1310110034#_760e17d1_01d1_4167_9398_c8ddfd61cc52
constant: false
type: Species
boundary condition: true
is encoded by: hsa:U52111
initial concentration: NaN
is: SBO:0000252
name: _U52111_1_c
has only substance units: false
initial amount: NaN

metaM taur c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
has only substance units: false
is: HMDB00251
name: Taurine
is: C00245
is: SBO:0000247
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_4be2cbbb_c412_49ae_b1f0_32da36921382
is: SBO:0000252
is: Q8TF71
has only substance units: false
type: Species
name: SLC16A10
is encoded by: hsa:117247
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR r0390
type: Reaction
is described by: ECO:0000000
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reactant: MODEL1310110034#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_a3a2ca83_5916_44e1_8aab_f6d4dd87f6e1
initial amount: NaN
is encoded by: hsa:81537
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q9BX95
boundary condition: true
initial concentration: NaN
name: SGPP1

http://identifiers.org/biomodels.db/MODEL1310110034#_98b53d12_ca53_4baf_b1dc_ef6969cf9e20
name: CA9
is encoded by: hsa:768
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q16790
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_7f904425_8bf0_4bde_842e_b39e36cb2375
has only substance units: false
is: O95498
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8875
name: VNN2
type: Species
initial concentration: NaN
boundary condition: true

metaM asp L m
is: HMDB00191
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
constant: false
is: SBO:0000247
type: Species
is: CHEBI:29991
initial amount: NaN

metaM cholcoads x
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: SBO:0000247
is: CHEBI:27505
is: HMDB06889
boundary condition: false

metaM dgdp c
type: Species
has only substance units: false
name: dGDP
boundary condition: false
is: HMDB00960
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
is: C00361
is: CHEBI:58595
constant: false

metaR GLCAASE1ly
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
reversible: false
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_086bb1be_fea8_466b_8adc_8712e4b558c0
constant: false
has only substance units: false
initial amount: NaN
name: HEPH
type: Species
initial concentration: NaN
boundary condition: true
is: E9PHN8
is encoded by: hsa:9843
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_be1a1053_3433_4114_a0eb_258cac8f3c4b
boundary condition: true
type: Species
is encoded by: hsa:2582
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q38G75
initial concentration: NaN
constant: false
name: GALE

metaR NACHEX25ly
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0391
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_95613c06_7677_4679_8cf2_ccbdc3284a44
is encoded by: hsa:8525
is: B7Z6M3
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: DGKZ
has only substance units: false
initial concentration: NaN

metaM ksi deg12 l
constant: false
is: HMDB00143
initial amount: NaN
type: Species
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
boundary condition: false
name: keratan sulfate I, degradation product 12
is: SBO:0000247

metaM pe hs e
constant: false
name: phosphatidylethanolamine
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16038
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaM dcdp m
name: dCDP(3-)
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
is: CHEBI:58593
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaM taur e
constant: false
initial concentration: 1.0
is: CHEBI:3544
name: Taurine
type: Species
is: HMDB00251
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
is: C00245

metaR r0392
kinetic law: MODEL1310110034#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110034#
is: SBO:0000176
fast: false
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000

metaR OCDCAtr
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: fatty acid transport via diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2d664a6d_95d0_4ebf_aacf_8831fde8143c
is encoded by: hsa:AA614647
initial concentration: NaN
name: _AA614647_1_c
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b290a20c_b4a9_4990_b1ff_0341ec27753f
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: BTD
is: SBO:0000252
is: P43251
is encoded by: hsa:686
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8cbca271_f522_4244_a5b7_9e7a1785bfd9
name: GALT
is: SBO:0000252
is encoded by: hsa:2592
has only substance units: false
constant: false
is: B4E097
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR ACHtn
is: SBO:0000185
fast: false
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
reversible: true
reactant: MODEL1310110034#

metaR C141CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR r1557
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaR DASPO1p
kinetic law: MODEL1310110034#
reversible: false
product: MODEL1310110034#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.4.3.1

http://identifiers.org/biomodels.db/MODEL1310110034#_afb862bf_cefa_4935_be0c_a11bf15e689f
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:2235
boundary condition: true
is: Q7KZA3
has only substance units: false
name: FECH

metaM ach n
initial amount: NaN
type: Species
name: acetylcholine
has only substance units: false
constant: false
is: CHEBI:15355
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_a8d35103_7826_47ba_87e0_ee3b591cc396
is encoded by: hsa:5172
is: SBO:0000252
name: SLC26A4
constant: false
type: Species
initial concentration: NaN
is: O43511
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r0423
is: SBO:0000176
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
type: Reaction
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_b32099de_48e8_427f_a042_de1dc18432d4
initial concentration: NaN
constant: false
is encoded by: hsa:AA081045
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: _AA081045_1_m

http://identifiers.org/biomodels.db/MODEL1310110034#_ea9051ef_8b67_4f50_ab26_57ce017909ed
name: _BG035985_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:BG035985
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_394b3d55_9708_4a16_94f8_84980753849c
is: SBO:0000252
is encoded by: hsa:3098
constant: false
boundary condition: true
initial concentration: NaN
is: P19367
type: Species
initial amount: NaN
has only substance units: false
name: HK1

metaR FADH2ETC
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Complex II reaction for respiratory chain
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: false
product: MODEL1310110034#

metaR EX c8crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR LINKDEG2ly
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176

metaR r0424
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
fast: false
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_be83034c_2f40_4768_bddc_c7c03be75f46
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P48728
constant: false
name: AMT
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:275

http://identifiers.org/biomodels.db/MODEL1310110034#_d73715b4_f721_4d3f_afc9_09e7b148efaa
is: P18859
name: ATP5J
is encoded by: hsa:522
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_b87250d2_3721_4722_99b8_4346a4a59687
constant: false
has only substance units: false
is: Q99707
name: MTR
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4548

http://identifiers.org/biomodels.db/MODEL1310110034#_8d9b1dd1_28a3_492c_8a96_e2ea70870f76
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:248
has only substance units: false
type: Species
is: P09923
name: ALPI
initial amount: NaN
initial concentration: NaN

metaR r0179
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110034#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e1189e75_1710_473d_a2d7_b77e9db1fc4b
type: Species
is: P23786
is encoded by: hsa:1376
initial amount: NaN
initial concentration: NaN
name: CPT2
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR S4TASE4ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR SERHL
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.3.1.17
name: L-Serine hydro-lyase
reversible: false

metaR ADNCYC
is: SBO:0000176
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
name: adenylate cyclase
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.6.1.1
reversible: false
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_40602520_bf33_42d8_8b20_6bac9851b418
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q1EHB4
is encoded by: hsa:159963
name: SLC5A12
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GALASE6ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_e999f578_2b5d_47bd_b2f4_3197c1c5743f
is: O00754
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: MAN2B1
is encoded by: hsa:4125

metaR CERT1rt
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
type: Reaction
name: ceramide transport protein
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110034#
is described by: ECO:0000304
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_7a6ea4bd_743d_46eb_b5ec_cd2a0779e5b7
has only substance units: false
initial amount: NaN
name: PRDX1
type: Species
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR NCAMUP
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
fast: false
product: MODEL1310110034#
type: Reaction
reversible: false
is: SBO:0000185
name: Nicotinamide acid uptake
is described by: ECO:0000000
kinetic law: MODEL1310110034#

metaR H7 TAer
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
name: H7' transamidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

metaR r0539
type: Reaction
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_56e0ba5c_a09b_499e_969d_767ebef3985c
name: LSS
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: E9PEI9
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4047

http://identifiers.org/biomodels.db/MODEL1310110034#_fcd19363_9ef1_4245_a556_966ee6c5c2c6
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10423
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: O14735
name: CDIPT

http://identifiers.org/biomodels.db/MODEL1310110034#_eef04680_1def_4284_a9d3_093aa0cc3788
constant: false
is encoded by: hsa:8898
initial amount: NaN
initial concentration: NaN
type: Species
is: A6NN98
name: MTMR2
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_5f9f4da9_1712_48fa_8653_0e52e56d3552
is encoded by: hsa:513
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ATP5D
constant: false
type: Species
initial amount: NaN

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
fast: false
type: Reaction
name: valine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_d6fc17be_ca02_4733_a24a_41eebf44064e
initial amount: NaN
is encoded by: hsa:11226
name: GALNT6
is: SBO:0000252
has only substance units: false
constant: false
is: Q8NCL4
type: Species
boundary condition: true
initial concentration: NaN

metaM aacoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
name: acetoacetyl-CoA(4-)
constant: false
is: CHEBI:57286
is: HMDB01484
boundary condition: false
type: Species

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM dpcoa c
type: Species
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: C00882
is: HMDB01373
is: SBO:0000247
name: Dephospho-CoA
has only substance units: false

metaM h x
name: proton
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
boundary condition: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110034#_75e61b37_3601_41b9_823c_c55c990ce3e6
is: Q9UKG4
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:26266
initial concentration: NaN
name: SLC13A4
type: Species
boundary condition: true
is: SBO:0000252

metaR ORNt4m
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110034#
name: ornithine mitochondrial transport exchange with citruline
reversible: true
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110034#

metaM pail345p hs c
is: SBO:0000247
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
has only substance units: false
is: CHEBI:57836
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981

metaR FMNAT
name: FMN adenylyltransferase
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
type: Reaction
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000134

metaM apoC Lys btn m
constant: false
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
initial amount: NaN
is: HMDB03134
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: C05552

metaR ASCBt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_8417f84d_bcae_4c47_b53d_5f0fbe21e401
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103
boundary condition: true
initial amount: NaN
is: Q6LEN6

metaM xyl D e
initial concentration: 1.0
is: SBO:0000247
name: aldehydo-D-xylose
constant: false
is: CHEBI:15936
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
type: Species
initial amount: NaN

metaR DSAT
kinetic law: MODEL1310110034#
name: dihydrosphingosine N-acyltransferase
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110034#_d9191b19_7239_4bca_9893_2de4fe7eb3ed
initial amount: NaN
type: Species
name: ACSL6
constant: false
is: B2RB13
is encoded by: hsa:23305
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_ccf60fa5_e933_49ac_974e_a56272660f7b
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10423
initial concentration: NaN
is: A8K3L7
type: Species
name: CDIPT
has only substance units: false
is: SBO:0000252

metaR CYTK8n
reversible: true
name: cytidylate kinase (CMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110034#

metaM c10dc c
notes: FORMULA: C17H30NO6 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00651
constant: false
name: sebacoyl carnitine
initial concentration: 1.0

metaR AKR1C42
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110034#

metaR C14STRr
name: C-14 sterol reductase
is: SBO:0000176
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000134
fast: false

metaM dpcoa e
initial amount: NaN
initial concentration: 1.0
is: C00882
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
type: Species
is: CHEBI:57328
constant: false
name: Dephospho-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ba2daa69_6d4c_4053_aa4a_d8ab95057ccf
boundary condition: true
is encoded by: hsa:60481
type: Species
initial concentration: NaN
name: ELOVL5
is: F6SH78
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_85bf6be5_9de6_4e27_8e9f_f0a970930c93
name: SLC5A3
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6526
boundary condition: true
is: P53794

metaM gt2 hs g
constant: false
boundary condition: false
notes: FORMULA: C71H117N5O41FULLRCO CHARGE: -3
type: Species
name: GT2
has only substance units: false
is: CHEBI:28648
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM c4dc x
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C02862
is: HMDB02013
is: SBO:0000247
name: succinyl carnitine
notes: FORMULA: C11H18NO6 CHARGE: -1
type: Species
is: http://identifiers.org/pubchem.compound/213144
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_17663f28_8c2f_478f_a6a1_2dc028cac361
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:728226
constant: false
is: SBO:0000252
name: _728226_1_m

http://identifiers.org/biomodels.db/MODEL1310110034#_27cfad31_9ede_4e5b_abb8_f6f7c68c2361
name: ACP1
has only substance units: false
initial amount: NaN
constant: false
is: P24666
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:52

metaM ksii core2 deg2 l
constant: false
has only substance units: false
is: CHEBI:12936
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 2

metaM xyl D c
name: aldehydo-D-xylose
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
type: Species
initial concentration: 1.0

metaM dhea c
boundary condition: false
is: CHEBI:28689
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: HMDB00077
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
has only substance units: false

metaR GLUt6
name: Glutamate transport via Na, H symport and K antiport
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
type: Reaction
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_56232792_c64b_4407_a45d_62804328a3b0
name: NDUFS8
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4728
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: O00217

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR r0173
product: MODEL1310110034#
fast: false
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.19
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_18b09715_3380_4781_998a_d839fa45dcfc
name: PCK2
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q16822
is encoded by: hsa:5106
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_dac53366_e5af_4ec3_afd9_e76f5d991a8a
is: P56385
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:521
type: Species
constant: false
name: ATP5I
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_21114437_ccb8_42ef_ba95_6f0f64030fd3
name: PYCR2
initial amount: NaN
is: Q96C36
is encoded by: hsa:29920
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM 3pg c
initial amount: NaN
is: HMDB00807
initial concentration: 1.0
constant: false
is: CHEBI:58272
has only substance units: false
is: C00197
name: 3-Phospho-D-glycerate
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3497
is: SBO:0000247

metaR HOXG
is described by: ECO:0000134
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
name: Heme oxygenase 1
reversible: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme

metaM gsn c
is: CHEBI:16750
initial amount: NaN
boundary condition: false
is: HMDB00133
initial concentration: 1.0
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
constant: false
has only substance units: false
name: Guanosine
type: Species

metaM sbcoa c
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
type: Species
is: C02838
name: suberylcoa
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00791
is: SBO:0000247

metaM bilglcur e
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
is: CHEBI:57767
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
constant: false

metaR SUBERICACT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaM biocyt m
is: HMDB03134
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C05552
initial amount: NaN
name: Biocytin
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false

metaR 34DHPLACOX
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110034#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
fast: false

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR FAOXC5C5DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e02d7e62_795d_44b5_be20_97dd42c1eb37
has only substance units: false
name: _8781_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:8781
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_70800afd_72c9_4b66_9fd8_a50894e2bef4
is: Q8WVQ1
constant: false
initial amount: NaN
is encoded by: hsa:124583
is: SBO:0000252
name: CANT1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaM ach c
constant: false
boundary condition: false
is: CHEBI:15355
has only substance units: false
initial amount: NaN
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00895

metaR CYSGLYexR
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: L-cysteine/glycine reversible exchanger
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_666cb5fa_64e0_4e5e_a4f4_8e2f063be52d
constant: false
initial concentration: NaN
is: O60427
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: FADS1
initial amount: NaN
is encoded by: hsa:3992

metaM bilglcur c
is: CHEBI:57767
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaM ach e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00895
is: CHEBI:15355
is: SBO:0000247
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
constant: false
name: acetylcholine

metaM adpcoa c
has only substance units: false
initial concentration: 1.0
name: adipoylcoa
is: C14143
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
is: SBO:0000247

metaM ksi deg24 l
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 24
type: Species
notes: FORMULA: C118H191N8O101S5 CHARGE: -5

metaR NDPK10
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_6b3834d3_ebd8_409f_9b26_6977802417eb
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: TREH
constant: false
type: Species
is encoded by: hsa:11181
is: O43280
has only substance units: false
initial amount: NaN

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_fb611832_b18f_473c_9c8b_d82f362faee9
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PLCH1
is: Q4KWH8
is encoded by: hsa:23007
type: Species

metaR S6TASE24ly
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

metaM HC01459 x
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial concentration: 1.0
constant: false
is: CHEBI:27458
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
has only substance units: false

metaM ser D e
boundary condition: false
is: HMDB03406
constant: false
name: D-serine
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16523
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR r0531
kinetic law: MODEL1310110034#
fast: false
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is: SBO:0000176
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM ttdca c
initial concentration: 1.0
is: HMDB00806
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: myristate
constant: false
is: CHEBI:30807
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR APRGSTRNte
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
name: hydroxyprogesterone transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

W3 CDTF: Thu Aug 30 15:08:32 BST 2012

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaR HSD17B9r
fast: false
name: 17-beta-hydroxysteroid dehydrogenase (type 7)
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ
is: SBO:0000176
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.62
type: Reaction
is described by: ECO:0000304
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110034#

W3 CDTF: Thu Aug 30 15:08:32 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110034#_af5f52b0_322c_4eb1_b899_f41e8c902e21
constant: false
is: Q9Y2T3
name: GDA
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9615

metaM pro D c
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: D-proline
is: CHEBI:16313

metaM ppi x
name: Diphosphate
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00250
is: C00013
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:33019
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM gpi sig r
initial concentration: 1.0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
notes: FORMULA: Y CHARGE: 0
initial amount: NaN
constant: false
is: CHEBI:58190
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00224

metaR FBP
is version of: http://identifiers.org/ec-code/3.1.3.11
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
name: fructose-bisphosphatase
fast: false
kinetic law: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
type: Reaction

metaM ser D c
type: Species
name: D-serine
is: CHEBI:16523
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB03406
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaR r1540
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM dpcoa m
name: 3'-dephospho-CoA(2-)
is: HMDB01373
is: SBO:0000247
type: Species
is: CHEBI:57328
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0

metaM malcoa e
constant: false
boundary condition: false
is: HMDB01175
name: malonyl-CoA(4-)
is: CHEBI:57384
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM aacoa x
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
is: CHEBI:57286
constant: false
name: acetoacetyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
type: Species

metaM udpg r
has only substance units: false
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial concentration: 1.0
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
type: Species
constant: false
is: HMDB00286
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_52cf5bf2_6d4d_4169_9941_c023704f9a42
boundary condition: true
initial concentration: NaN
is: Q308M7
constant: false
type: Species
is: SBO:0000252
name: ENPP3
is encoded by: hsa:5169
has only substance units: false
initial amount: NaN

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR HSD3B12r
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110034#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_2582d880_5134_43c1_9bd9_c83ec69de4ab
boundary condition: true
initial amount: NaN
is: Q15274
initial concentration: NaN
name: QPRT
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:23475

metaM andrstndn r
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
initial amount: NaN
is: HMDB00053
name: androst-4-ene-3,17-dione
boundary condition: false
initial concentration: 1.0
is: CHEBI:16422

metaR GCHOLAte
name: bile acid intracellular transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c9726124_db54_4ab5_a9c6_93dd9804aeaf
has only substance units: false
is: SBO:0000252
boundary condition: true
name: KDSR
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q06136
is encoded by: hsa:2531

metaM mev R c
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species
is: CHEBI:36464
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: (R)-mevalonate
boundary condition: false
is: HMDB00227

metaR NDPK9
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_7769d3ce_207f_4107_8882_96979d1e0f93
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: FLAD1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80308

metaM mercplaccys e
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
is: SBO:0000247
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

metaM biocyt e
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
initial amount: NaN
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
is: C05552

http://identifiers.org/biomodels.db/MODEL1310110034#_67338387_f6f2_4d92_8b0c_8bb37d65c101
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2182
is: O60488
name: ACSL4
type: Species
is: SBO:0000252

metaR r2352
reactant: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
fast: false

metaM tdchola c
is: HMDB00951
type: Species
initial amount: NaN
name: taurochenodeoxycholate
is: CHEBI:9407
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM h l
has only substance units: false
is: C00080
type: Species
boundary condition: false
is: CHEBI:24636
initial amount: NaN
name: proton
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247

metaM amp x
initial amount: NaN
is: CHEBI:456215
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
boundary condition: false
name: AMP
is: HMDB00045
is: C00020
is: SBO:0000247
type: Species

metaR r1546
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_cec024cd_6584_4c96_a0b3_e60cac7c2595
name: NDUFB2
is encoded by: hsa:4708
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: H7C5B8
initial concentration: NaN

metaM udpg c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58367
is: HMDB00286
initial concentration: 1.0
name: UDPglucose
is: C00029
type: Species
boundary condition: false
constant: false

metaM ak2lgchol hs e
constant: false
boundary condition: false
is: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: http://identifiers.org/pubchem.compound/6975
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_0260739b_50c9_44a1_986f_182de9f18048
is: Q5DSZ6
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: UGT1A8
is: SBO:0000252
is encoded by: hsa:54576

metaM C05965 e
constant: false
initial concentration: 1.0
name: 12(S)-HPETE(1-)
type: Species
is: HMDB04243
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57444

metaR r0027
kinetic law: MODEL1310110034#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
fast: false
modifier: MODEL1310110034#

metaR NDPK7
name: nucleoside-diphosphate kinase (ATP:dCDP)
is described by: ECO:0000269
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM ppi r
is: SBO:0000247
is: C00013
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
name: Diphosphate
is: CHEBI:33019
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_4c3d78a2_fb8e_414d_bb47_ef73352f65b7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6817
initial concentration: NaN
has only substance units: false
name: SULT1A1
constant: false
boundary condition: true
type: Species

metaM biocyt c
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
initial concentration: 1.0
is: C05552
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM c4dc c
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
name: succinyl carnitine
initial amount: NaN
type: Species
is: C02862
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02013
notes: FORMULA: C11H18NO6 CHARGE: -1

metaM cdp m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
name: CDP(3-)
has only substance units: false
is: HMDB01546
initial amount: NaN
constant: false

metaM tdchola e
has only substance units: false
is: HMDB00951
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: taurochenodeoxycholate
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
boundary condition: false

metaR NDPK6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2304fa5b_b488_49c1_a4bc_ee72a44c2149
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: Q16773
is encoded by: hsa:883
name: CCBL1

metaM mercplaccys c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
type: Species
constant: false
is: HMDB06512
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1

metaM 3pg m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00807
is: CHEBI:58272
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
type: Species

metaR NDPK8
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110034#
name: Nucleoside-diphosphate kinase (ATP:dADP)
fast: false
modifier: MODEL1310110034#

metaR r1544
reversible: true
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c9cf70f4_f7b1_4bb8_bc4c_8667bec2d193
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: PLA2G6
is encoded by: hsa:8398
is: SBO:0000252
is: O60733
constant: false
has only substance units: false

metaM dhlam m
constant: false
is: CHEBI:17694
boundary condition: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00985
name: dihydrolipoamide
has only substance units: false
initial amount: NaN

metaM cs a deg2 l
boundary condition: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127
type: Species
is: SBO:0000247

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR EX cspg d LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_60416f23_1850_4e10_837e_77cbfe483844
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1384
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CRAT

metaM mi14p n
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
is: CHEBI:58282
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968

metaM idp n
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB03335
is: SBO:0000247
type: Species
has only substance units: false

metaR r0974
name: Active transport
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_756b0eb8_d67b_4420_9312_305074f45345
initial amount: NaN
is: P15848
has only substance units: false
name: ARSB
is encoded by: hsa:411
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM 3oddcoa x
initial amount: NaN
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
has only substance units: false
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
boundary condition: false
constant: false
is: HMDB03937
is: SBO:0000247

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACACT1r
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#
name: acetyl-CoA C-acetyltransferase
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false

metaR ST8SIA55g
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
reversible: false
product: MODEL1310110034#
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110034#

metaM dchac e
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: deoxycholic acid
initial concentration: 1.0
is: HMDB00626
notes: FORMULA: C24H39O4 CHARGE: -1
type: Species

metaR r0750
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110034#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000
modifier: MODEL1310110034#
product: MODEL1310110034#

metaR GLUDxm
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
name: glutamate dehydrogenase (NAD) (mitochondrial)
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110034#

metaM k c
is: HMDB00586
type: Species
name: potassium
is: CHEBI:29103
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_cd0f41a3_7fb4_4845_b273_77eb3505146e
is encoded by: hsa:23236
constant: false
is: Q9NQ66
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: PLCB1
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_1bc75be4_d60d_4a23_9e55_1b6a2e894db8
is: O95045
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:151531
name: UPP2
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_ac0b2f4a_f702_4555_9561_2ab9ad18771d
has only substance units: false
is: B3KU59
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6547
initial amount: NaN
type: Species
name: SLC8A3
is: SBO:0000252

metaR r2356
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction

metaR r0973
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Facilitated diffusion
fast: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#

metaR r0644
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reversible: true
reactant: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#

metaR EX 3ddcrn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR UGCG
is version of: http://identifiers.org/ec-code/2.4.1.80
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
name: Ceramide glucosyltransferase
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110034#

metaR r0181
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM ocdcea e
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
is: CHEBI:0
type: Species
is: HMDB00207
is: SBO:0000247
name: octadecenoate (n-C18:1)
has only substance units: false
is: C00712

http://identifiers.org/biomodels.db/MODEL1310110034#_98eb43c8_c517_4991_a990_7c0a8dc0f9d2
initial amount: NaN
is: Q5JAM2
initial concentration: NaN
constant: false
is encoded by: hsa:211
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: ALAS1

metaM h g
is: CHEBI:24636
name: proton
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
has only substance units: false
type: Species

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
is: SBO:0000185

metaM cdp n
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
name: CDP(3-)
has only substance units: false
initial amount: NaN
is: CHEBI:58069
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01546

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR NACHEX13ly
is described by: ECO:0000000
modifier: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction

metaR 3SALAASPm
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
product: MODEL1310110034#
reversible: true
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110034#
name: cysteinesulfinate-aspartate mitochondrial shuttle
is: SBO:0000185
fast: false

metaM gar c
is: HMDB02022
is: C03838
boundary condition: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58457
name: N1-(5-Phospho-D-ribosyl)glycinamide

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD

metaM dctp c
type: Species
name: dCTP
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
initial concentration: 1.0
is: C00458
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16311
boundary condition: false

metaR r0647
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Spontaneous reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true

metaM glyc R m
has only substance units: false
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: D-glycerate
is: HMDB00139
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_794dc9a3_da34_4659_abe9_393ac2472d26
type: Species
initial amount: NaN
is encoded by: hsa:4701
constant: false
has only substance units: false
is: Q6FG42
name: NDUFA7
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r1547
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#

metaR r0752
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ppi n
is: HMDB00250
initial amount: NaN
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
initial concentration: 1.0
name: diphosphate(3-)
boundary condition: false
is: SBO:0000247
is: CHEBI:33019
type: Species

metaM cdpdag hs c
is: CHEBI:58332
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
has only substance units: false
name: CDP-diacylglycerol(2-)
initial amount: NaN

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR r2354
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#

W3 CDTF: Thu Aug 30 15:08:33 BST 2012

metaR r1548
is: SBO:0000185
fast: false
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r0022
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110034#
is: SBO:0000176
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_ee3e8a86_349b_4937_a6fd_d72500f32116
constant: false
initial concentration: NaN
type: Species
is: P39877
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5322
boundary condition: true
name: PLA2G5

http://identifiers.org/biomodels.db/MODEL1310110034#_c4a8455e_ef93_46f2_93fc_c787379f7805
is encoded by: hsa:4700
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: P56556
type: Species
has only substance units: false
name: NDUFA6

http://identifiers.org/biomodels.db/MODEL1310110034#_1b42d9f4_1df0_49bc_bf0a_676c03d2ef50
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:83549
is: Q5JT09
constant: false
boundary condition: true
name: UCK1
has only substance units: false
is: SBO:0000252

metaM ksi deg30 l
has only substance units: false
type: Species
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
name: keratan sulfate I, degradation product 30
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
constant: false
initial amount: NaN
boundary condition: false

metaR r2353
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185

metaM ocdcea c
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:0
type: Species
has only substance units: false
is: HMDB00207
name: octadecenoate (n-C18:1)
initial concentration: 1.0

metaM ak2lgchol hs c
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C04317
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975

metaM h e
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
type: Species
name: proton
is: C00080
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110034#_f67391ed_51de_41f1_9460_a1148de49354
constant: false
name: SLC25A6
is: Q6I9V5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:293
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM ca2 e
constant: false
initial concentration: 1.0
is: SBO:0000247
name: calcium(2+)
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
has only substance units: false
is: HMDB00464
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_97cceb53_e506_4c5c_82fe_9dd1c9d9b097
is: SBO:0000297
has part: O95498
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:55350
is encoded by: hsa:8875
constant: false
has only substance units: false
boundary condition: true
name: VNN3:VNN2:VNN1

http://identifiers.org/biomodels.db/MODEL1310110034#_86641b06_687b_4b74_8d10_6cf795ddbd9b
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: _AI761708_1_m
has only substance units: false
type: Species
is encoded by: hsa:AI761708

metaR r0021
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reversible: true
reactant: MODEL1310110034#
fast: false

metaR LEUt5m
type: Reaction
kinetic law: MODEL1310110034#
fast: false
reversible: true
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR C6DCCACT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR r0641
reactant: MODEL1310110034#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110034#
is: SBO:0000176

metaR r0754
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
reversible: true
product: MODEL1310110034#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR FUMtm
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
reactant: MODEL1310110034#
is described by: ECO:0000269
name: fumarate transport, mitochondrial
reversible: true

metaM HC01407 m
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:28276
boundary condition: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
has only substance units: false
name: (S)-Hydroxyhexanoyl-CoA

metaR PRO Dtde
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000134
reversible: true
name: D-proline transport, extracellular

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
boundary condition: false
name: CDP
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58069
is: HMDB01546
has only substance units: false
type: Species
is: C00112

metaR SRTNt6 2 r
reversible: true
fast: false
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

W3 CDTF: Thu Aug 30 15:08:33 BST 2012

metaR NDPK1
modifier: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
name: nucleoside-diphosphate kinase (ATP:GDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110034#
reversible: true

metaR CO2t
fast: false
reversible: true
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110034#
type: Reaction
name: CO2 transporter via diffusion

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00250
is: CHEBI:33019
boundary condition: false
type: Species
is: C00013
name: Diphosphate

metaR r0753
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#

metaR r2359
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR ALAt2r
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000304
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
name: L-alanine reversible transport via proton symport

metaM ca2 c
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
has only substance units: false
constant: false
is: CHEBI:29108
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00464
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_bfe3daa2_7935_4cdf_a505_4a3b79babb5c
name: COX5B
initial amount: NaN
type: Species
has only substance units: false
is: Q53YB7
boundary condition: true
is encoded by: hsa:1329
constant: false
is: SBO:0000252
initial concentration: NaN

metaM k e
is: CHEBI:29103
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
has only substance units: false
is: C00238
is: HMDB00586

http://identifiers.org/biomodels.db/MODEL1310110034#_5d45ce80_682e_49dc_b734_c3d44057fbe8
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC19A3
initial concentration: NaN
is: Q9BZV2
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:80704

http://identifiers.org/biomodels.db/MODEL1310110034#_bdd82291_dd33_4e6f_ab28_95b31c11c922
has part: A7E2E0
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8503
has only substance units: false
is: SBO:0000297
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
has part: Q92569

metaM h r
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00080
name: proton
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR 10FTHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR r0308
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
type: Reaction
modifier: MODEL1310110034#

metaM amp r
is: SBO:0000247
initial amount: NaN
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00045
type: Species
name: AMP
is: C00020

metaM cdp e
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01546
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
name: CDP(3-)
initial amount: NaN

metaR r2358
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_16339b58_e782_4be7_9021_46e20a077ee4
name: PECR
initial concentration: NaN
type: Species
is encoded by: hsa:55825
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9BY49
constant: false

metaR r2357
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_ca9a3a67_85b8_42fd_9bea_4b37648cc3aa
has only substance units: false
boundary condition: true
is encoded by: hsa:4538
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: ND4
is: P03905
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_60c26410_bd96_435b_a0d6_061431456359
name: DGKI
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O75912
type: Species
is encoded by: hsa:9162
constant: false
is: SBO:0000252
has only substance units: false

metaR ACACt2
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_45797260_7dde_4cb5_b0a3_419dba397274
name: COX7A2L
has only substance units: false
is encoded by: hsa:9167
is: Q6FGA0
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR r0642
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR r0755
modifier: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
kinetic law: MODEL1310110034#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
type: Reaction

metaR MDHm
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
type: Reaction
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: malate dehydrogenase, mitochondrial
fast: false

metaR RE2655R
name: RE2655
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_63ecd344_4d0d_4560_be66_366b62124a6e
constant: false
initial amount: NaN
name: SLC13A3
initial concentration: NaN
has only substance units: false
is: B4DIR8
type: Species
boundary condition: true
is encoded by: hsa:64849
is: SBO:0000252

metaR NDPK4
type: Reaction
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dTDP)
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaM glyc R c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
is: HMDB00139
name: D-glycerate
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16659

http://identifiers.org/biomodels.db/MODEL1310110034#_5ef599a4_a8ad_4b40_9572_eb96bf960f81
name: ADO
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84890
is: B3KXN9
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM HC02202 c
has only substance units: false
is: SBO:0000247
name: prostaglandin A1(1-)
boundary condition: false
is: CHEBI:57398
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false
initial concentration: 1.0
type: Species

metaM cdpdag hs m
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
name: CDP-diacylglycerol(2-)
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58332

metaM gpail hs c
has only substance units: false
initial concentration: 1.0
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
is: CHEBI:17049
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248

http://identifiers.org/biomodels.db/MODEL1310110034#_0dea148b_ac6f_40a0_90ac_d72f6212dc0b
name: ALDH4A1
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:8659
is: SBO:0000252
initial concentration: NaN

metaR r0758
reactant: MODEL1310110034#
type: Reaction
reversible: true
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
fast: false

metaR NDPK5
product: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dGDP)
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_8545faad_f173_45ee_b85a_de5ae065227e
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:55512
is: A8K0T6
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SMPD3
is: SBO:0000252

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR DCMPDA
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reversible: true
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
reactant: MODEL1310110034#
name: dCMP deaminase

metaM dctp n
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998
name: dCTP
boundary condition: false
is: SBO:0000247
type: Species
is: C00458
constant: false
initial concentration: 1.0
is: CHEBI:16311
has only substance units: false
initial amount: NaN

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM cgly e
has only substance units: false
is: HMDB00078
type: Species
is: SBO:0000247
initial concentration: 1.0
name: L-cysteinylglycine
constant: false
initial amount: NaN
is: CHEBI:4047
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM ppbng c
name: Porphobilinogen
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00931
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
initial amount: NaN
is: HMDB00245
type: Species
is: CHEBI:58126

metaR ACGALK
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-acetylgalactosamine kinase

http://identifiers.org/biomodels.db/MODEL1310110034#_76f1647f_9db6_4083_8979_3c258f0c960f
is encoded by: hsa:80025
name: PANK2
has only substance units: false
is: Q9BZ23
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM h n
is: SBO:0000247
constant: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
type: Species
initial amount: NaN
name: proton
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_8a14cbf1_cbe3_4bcc_a291_569ad04adf50
is encoded by: hsa:8034
has only substance units: false
name: SLC25A16
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P16260
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_14d6810e_a82d_4c6e_aa3f_3272d3bd0420
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:761
is: P07451
type: Species
has only substance units: false
constant: false
name: CA3
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_57d9f5bb_d1ba_4c7e_b034_9b9a2507864b
has only substance units: false
is encoded by: hsa:3635
boundary condition: true
name: INPP5D
type: Species
is: Q92835
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaM 4abutn m
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
is: CHEBI:58264
constant: false
is: HMDB01080
name: 4-ammoniobutanal
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM 3oddcoa m
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
is: CHEBI:27868

metaR NDPK2
kinetic law: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
reversible: true
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110034#

metaM HC02202 e
is: SBO:0000247
name: prostaglandin A1(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:57398
boundary condition: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
initial concentration: 1.0

metaR FBA
modifier: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reactant: MODEL1310110034#
name: fructose-bisphosphate aldolase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_28b9c9d1_755d_4ec9_ae68_660584302bd7
initial amount: NaN
is encoded by: hsa:79143
is: SBO:0000252
type: Species
name: MBOAT7
boundary condition: true
initial concentration: NaN
is: Q96N66
constant: false
has only substance units: false

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM aps c
is: SBO:0000247
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01003
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224

metaM g3p c
boundary condition: false
is: C00661
is: CHEBI:58027
type: Species
has only substance units: false
name: Glyceraldehyde 3-phosphate
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
is: HMDB01112
initial concentration: 1.0

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
is: HMDB00078
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: L-cysteinylglycine
constant: false

metaR UDPACGALtl
reactant: MODEL1310110034#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
fast: false
product: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_003b65db_ab04_4276_90bd_73cbe4bf697d
name: CHIA
type: Species
is encoded by: hsa:27159
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: A8K3T7
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_50d4b9b8_a998_4a58_a703_eb5586e7df91
constant: false
name: NDUFB5
is: SBO:0000252
initial amount: NaN
is: O43674
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110034#_1f82eb7f_b9fa_4cff_a16f_ebd048a580af
is: SBO:0000252
initial amount: NaN
name: ATP5F1
initial concentration: NaN
is encoded by: hsa:515
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR NACHEX1ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110034#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#

metaR NDPK3
kinetic law: MODEL1310110034#
name: nucleoside-diphosphate kinase (ATP:CDP)
is described by: ECO:0000269
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_821653ea_aefe_4229_b834_e013521f577c
is: SBO:0000252
is encoded by: hsa:3033
name: HADH
is: Q16836
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
type: Species
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
is: C00080
initial amount: NaN
constant: false
has only substance units: false
name: proton
initial concentration: 1.0

metaM ddcacoa x
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C01832
has only substance units: false
initial amount: NaN
type: Species
is: HMDB03571

http://identifiers.org/biomodels.db/MODEL1310110034#_4f5f1947_6345_4f3b_a125_1abd847df6e4
is: Q7Z7B1
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:284098
name: PIGW
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_ba633ad2_a097_47af_85a4_5391b4361bbe
type: Species
initial amount: NaN
is: Q9Y345
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC6A5
is encoded by: hsa:9152
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_d6193fe5_d410_4d44_a782_728975bed526
is encoded by: hsa:3074
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: HEXB
initial concentration: NaN
is: P07686
type: Species

metaM ocdcea l
is: CHEBI:30823
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
name: oleate
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00207

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR S23Tg
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269
reactant: MODEL1310110034#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD

metaM idp e
is: HMDB03335
is: CHEBI:58280
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
constant: false
boundary condition: false
initial amount: NaN

metaR FAOXC5C5OHm
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f245e4e5_3ecc_472c_be0a_13bf25317bce
name: NDUFA11
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: C9JT23
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:126328
constant: false

metaM CE2420 m
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28387
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false

metaM core6 g
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Core 6
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
is: C04383

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
product: MODEL1310110034#

metaM ddcacoa c
is: HMDB03571
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
constant: false
is: CHEBI:57375
is: C01832
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaR S6TASE25ly
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false

metaR 5MTHFt2le
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000134
name: 5-methyltetrahydrofolate transport via anion exchange
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM akg c
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 2-Oxoglutarate
is: C00026
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: CHEBI:16810
is: SBO:0000247
is: HMDB00208

metaM CE4872 c
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaM HC00342 c
initial amount: NaN
name: cis-aconitate(3-)
is: CHEBI:16383
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_965f6b63_58b6_4678_82e8_3eb7c6443339
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: H0YMZ7
constant: false
is encoded by: hsa:5151
boundary condition: true
type: Species
name: PDE8A
is: SBO:0000252

metaM ksi deg26 l
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
constant: false
name: keratan sulfate I, degradation product 26
is: CHEBI:58343
initial concentration: 1.0
boundary condition: false
is: HMDB00061
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_6f756687_ba88_40f1_8466_b0f2382a9e45
is: Q9Y633
is encoded by: hsa:5136
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: PDE1A
is: SBO:0000252

metaR SERDGLNexR
is: SBO:0000185
is described by: ECO:0000304
reversible: true
name: D-Serine/Glutamine reversible exchange
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR r0437
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
fast: false
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR RETNt
kinetic law: MODEL1310110034#
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110034#
type: Reaction
fast: false

metaM 1pipdn2c x
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16187
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
name: 1-piperideine-2-carboxylate
is: HMDB01084
has only substance units: false

metaR 3SPYRSPm
is described by: ECO:0000000
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
reversible: false
product: MODEL1310110034#
fast: false
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reactant: MODEL1310110034#
is: SBO:0000176

metaR RE3270C
is: SBO:0000176
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: RE3270
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
product: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_8213bf77_4457_451a_ba81_087bd08f22c7
initial concentration: NaN
name: SLC5A10
is encoded by: hsa:125206
is: A0PJK1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR NACHEX11ly
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal

metaM prostge1 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: prostaglandin E1(1-)
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57397
is: HMDB01442
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false

metaR r0434
product: MODEL1310110034#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_f0f67a9c_5c06_4865_be02_f66b9e71ff1a
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P00492
initial concentration: NaN
constant: false
has only substance units: false
name: HPRT1
is encoded by: hsa:3251

http://identifiers.org/biomodels.db/MODEL1310110034#_24321a57_65e2_49ce_9ec4_fc925d967ded
name: _T83654_1_m
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:T83654
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_a13fbbf7_d88e_4cbe_a089_739176f01f66
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _LOC727762_1_m
initial amount: NaN
type: Species
is encoded by: hsa:LOC727762

http://identifiers.org/biomodels.db/MODEL1310110034#_b6e2054a_21ce_4d99_a02a_806d51020fa4
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR MTHFD
is: SBO:0000176
type: Reaction
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP)
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
modifier: MODEL1310110034#
product: MODEL1310110034#

metaR r0547
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.17.1.4
is described by: ECO:0000000
type: Reaction
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
product: MODEL1310110034#

metaM urate e
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00366
is: HMDB00289
name: Urate
constant: false
initial concentration: 1.0
is: CHEBI:17775
is: SBO:0000247

metaM hs deg19 l
name: heparan sulfate, degradation product 19
initial concentration: 1.0
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
is: HMDB01352
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17180
initial amount: NaN
boundary condition: false

metaM CE5854 e
name: gama-CEHC-glucuronide
is: HMDB02710
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: CHEBI:27485
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_33f50692_8854_4059_a383_0bbf86e3f9f7
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: P22413
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ENPP1
is encoded by: hsa:5167

metaM akg e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
name: 2-oxoglutarate(2-)
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

metaM xol7ah2 c
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28047
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_92048df5_4f70_4239_b73a_18a1343b10de
is: P78330
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5723
name: PSPH
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_d0d7e6b6_1fde_4043_b2b6_2bedeb987b6e
type: Species
has only substance units: false
is: B2RBR4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6575
name: SLC20A2
boundary condition: true
constant: false
initial amount: NaN

metaR BHBtm
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV

http://identifiers.org/biomodels.db/MODEL1310110034#_8ca96fc8_9975_4e63_8596_6ca9f7ebcb90
is: Q96C36
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PYCR2
is encoded by: hsa:29920
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_173896b8_b2a7_432c_a6a9_ae6d640f818e
constant: false
is encoded by: hsa:11000
is: SBO:0000252
boundary condition: true
is: Q5K4L6
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC27A3

metaR MTHFC
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110034#
fast: false

metaM lpchol hs e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:60479
type: Species
name: lysophosphatidylcholine

metaM leuktrC4 e
type: Species
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57973
name: leukotriene C4(2-)
boundary condition: false
constant: false
is: HMDB01198

metaM 3sala m
boundary condition: false
name: 3-sulfino-L-alanine (1-)
initial amount: NaN
has only substance units: false
type: Species
is: C00606
is: SBO:0000247
is: CHEBI:61085
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaM prostge1 e
initial concentration: 1.0
constant: false
initial amount: NaN
name: prostaglandin E1(1-)
is: SBO:0000247
type: Species
is: HMDB01442
has only substance units: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM gdpfuc g
initial amount: NaN
is: CHEBI:57984
boundary condition: false
has only substance units: false
name: GDP-L-fucose(2-)
initial concentration: 1.0
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
type: Species
is: HMDB01095

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
type: Species
name: D-4'-Phosphopantothenate
boundary condition: false
is: C03492
is: HMDB01016
initial amount: NaN
is: CHEBI:10986
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_00c99426_632b_4bac_ac76_fb3334de8326
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ELOVL2
initial concentration: NaN
constant: false
is encoded by: hsa:54898
is: Q9NXB9
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_f22ee723_c967_4f15_a051_05380565ce29
type: Species
is: P30613
initial amount: NaN
constant: false
has only substance units: false
name: PKLR
is encoded by: hsa:5313
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM sarcs m
initial concentration: 1.0
boundary condition: false
is: C00213
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
type: Species
is: CHEBI:15611
is: HMDB00271
name: Sarcosine
constant: false
has only substance units: false
initial amount: NaN

metaR GLCNACASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
reversible: false

metaM cl c
is: CHEBI:3966
is: SBO:0000247
initial concentration: 1.0
is: HMDB00492
type: Species
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
name: Chloride
initial amount: NaN
boundary condition: false
is: C00115
constant: false

metaR DTDPtn
type: Reaction
kinetic law: MODEL1310110034#
name: dTDP nuclear transport
reversible: true
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000

metaM urate c
is: CHEBI:17775
name: Urate
initial concentration: 1.0
initial amount: NaN
is: HMDB00289
is: SBO:0000247
constant: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
boundary condition: false
has only substance units: false
is: C00366
type: Species

metaM gly c
boundary condition: false
constant: false
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
is: CHEBI:3339
has only substance units: false
type: Species
is: HMDB00123
is: SBO:0000247
name: Glycine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_bce33c9e_62ca_4eff_8244_4af740c08abd
name: GGCT
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:79017
boundary condition: true
is: B8ZZR8
initial concentration: NaN
initial amount: NaN

metaM dgtp c
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
is: HMDB01440
type: Species
is: CHEBI:16497
has only substance units: false
initial amount: NaN
is: C00286
name: dGTP
boundary condition: false
initial concentration: 1.0

metaM adpcoa x
has only substance units: false
initial amount: NaN
is: HMDB04047
constant: false
initial concentration: 1.0
name: adipoylcoa
boundary condition: false
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_477fe588_3550_478f_8e0e_f770e81dec90
type: Species
is: SBO:0000252
is: B1AK53
name: ESPN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:83715
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_eb486bf2_787b_431f_ad03_64a66b91741a
constant: false
initial concentration: NaN
boundary condition: true
name: ST8SIA5
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O15466
type: Species
is encoded by: hsa:29906

metaM L2aadp6sa c
name: L-allysine
initial amount: NaN
is: HMDB01263
initial concentration: 1.0
boundary condition: false
is: CHEBI:17917
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
type: Species

metaM lpchol hs c
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60479
has only substance units: false
name: lysophosphatidylcholine
type: Species

metaM leuktrC4 c
name: leukotriene C4(2-)
is: CHEBI:57973
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01198
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

http://identifiers.org/biomodels.db/MODEL1310110034#_509c04fb_7a65_4bd5_9570_92002e2e04f8
is encoded by: hsa:10568
boundary condition: true
initial concentration: NaN
is: O95436
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: SLC34A2

http://identifiers.org/biomodels.db/MODEL1310110034#_580f59ff_9518_4d9b_9dea_85cfe3e18391
is: O00767
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6319
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: SCD

metaM sbcoa x
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB02014
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
name: suberylcoa

metaR PGPP hs
name: Phosphatidylglycerol phosphate phosphatase (homo sapiens)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.27 Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176

metaR H3ETer
fast: false
modifier: MODEL1310110034#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
kinetic law: MODEL1310110034#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176

metaR NACHEX12ly
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110034#_a0768cf7_d187_4eae_a9fe_78ef761ab09e
initial amount: NaN
name: CRLS1
boundary condition: true
has only substance units: false
is encoded by: hsa:54675
is: Q9UJA2
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM gly e
constant: false
is: C00037
boundary condition: false
initial amount: NaN
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
is: SBO:0000247
type: Species
has only substance units: false
name: Glycine
initial concentration: 1.0

metaM ksii core2 deg1 l
name: keratan sulfate II (core 2-linked), degradation product 1
constant: false
type: Species
initial amount: NaN
is: HMDB00868
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: CHEBI:57737
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM ksi deg25 l
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
name: keratan sulfate I, degradation product 25
is: CHEBI:16953
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00812
constant: false
initial amount: NaN

metaM cl e
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
is: C00115
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00492
has only substance units: false
name: Chloride

metaM hs deg16 l
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:21338
type: Species
is: HMDB02704
initial concentration: 1.0
name: heparan sulfate, degradation product 16
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_4ef50c71_3202_4f6f_900d_b0fb3fd6849d
has only substance units: false
initial amount: NaN
name: PLD2
boundary condition: true
is: O14939
is encoded by: hsa:5338
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR r1810
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#

metaM uri c
is: CHEBI:16704
constant: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
is: SBO:0000247
has only substance units: false
is: C00299
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Uridine

metaM dgtp e
is: HMDB01440
type: Species
is: CHEBI:16497
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
name: dGTP
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM gdpfuc c
initial concentration: 1.0
is: CHEBI:57984
initial amount: NaN
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: GDP-L-fucose(2-)
constant: false
is: HMDB01095

metaR MDHx
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
name: malate dehydrogenase, peroxisomal
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2ca190e2_9a46_44d8_9891_3de94f4f5d37
is: Q8IWU9
is: SBO:0000252
type: Species
name: TPH2
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:121278

http://identifiers.org/biomodels.db/MODEL1310110034#_5fff1689_cf54_44db_b550_bd8a43b6bdda
has only substance units: false
name: PRDX1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5052

http://identifiers.org/biomodels.db/MODEL1310110034#_e7e0717c_de29_4861_8a5d_4eb8f943109a
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9NRX3
name: NDUFA4L2
is encoded by: hsa:56901

metaM 3aib m
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial amount: NaN
has only substance units: false
is: HMDB02166
is: CHEBI:33094
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_93be8127_87d0_416f_9bda_9e14bdaaeca7
initial concentration: NaN
is encoded by: hsa:6535
has only substance units: false
boundary condition: true
is: B4DIA3
name: SLC6A8
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR CGLYt3 2
kinetic law: MODEL1310110034#
is: SBO:0000185
modifier: MODEL1310110034#
name: Cys-Gly transport in via proton symport
reactant: MODEL1310110034#
reversible: false
is described by: ECO:0000304
type: Reaction
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaR r0541
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
fast: false
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
reversible: true
is described by: ECO:0000000

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
is: CHEBI:57795
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR P4507A1r
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.17
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
kinetic law: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f4f707d1_ef43_4d74_b8b5_137afbe4b173
has only substance units: false
initial amount: NaN
is: Q9H999
name: PANK3
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79646
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_679b3b51_0fc7_4b06_b99a_650c95271eba
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GPX1
type: Species
is encoded by: hsa:2876
initial concentration: NaN
boundary condition: true
constant: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR PPPGOm
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.4
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
name: protoporphyrinogen oxidase, mitochondrial
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000304
product: MODEL1310110034#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e60b616c_afbc_4a70_8379_eb49a40ce4e8
name: PPAT
is: Q06203
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5471
constant: false
initial amount: NaN

metaR ACONTm
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000134
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
name: Aconitate hydratase
reactant: MODEL1310110034#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_d30ef6a9_c071_4863_bd65_3bc94d6526e5
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: LDHB
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3945
is: SBO:0000252
is: P07195

http://identifiers.org/biomodels.db/MODEL1310110034#_ab466eb6_3293_48bc_969b_60b4f25cadff
is: SBO:0000252
constant: false
initial amount: NaN
is: P27707
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1633
boundary condition: true
type: Species
name: DCK

http://identifiers.org/biomodels.db/MODEL1310110034#_c7d5278d_1fd4_4933_9c7a_95ed7b9c196d
is: Q92947
initial concentration: NaN
name: GCDH
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2639

metaM galgluside hs g
is: CHEBI:58223
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: galactosyl glucosyl ceramide
is: HMDB00295
is: C00015
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8bc72553_1cf0_439b_8dbc_20d3d09e1989
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACP1
type: Species
is: B5MCC7
is encoded by: hsa:52

metaR NAIt
is described by: ECO:0000269
name: Na+ / iodide cotransport
type: Reaction
reactant: MODEL1310110034#
reversible: true
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD

metaR GTHPm
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
product: MODEL1310110034#
is described by: ECO:0000269
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#

metaM dodecanac x
type: Species
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
boundary condition: false
is: SBO:0000247
is: HMDB00623
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR KCCt
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransport
reactant: MODEL1310110034#

metaR CYTK9n
fast: false
type: Reaction
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP),nuclear
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110034#
is described by: ECO:0000269

metaR THRGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
fast: false
name: L-threonine/glycine reversible exchange
product: MODEL1310110034#
is described by: ECO:0000304

metaM sarcs c
has only substance units: false
is: HMDB00271
is: C00213
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:3513
constant: false
name: Sarcosine
notes: FORMULA: C3H7NO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_392f4a2f_bc20_439a_95bc_ea95a413bf59
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has part: P51553
is encoded by: hsa:3420
has part: O43837
is encoded by: hsa:3421
is: SBO:0000297
initial amount: NaN
name: IDH3A:IDH3B:IDH3G
has only substance units: false

metaM gal1p c
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: HMDB00645
is: CHEBI:58336
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaM CE0785 m
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: cis,cis-myristo-5,8-dienoyl-CoA
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110034#_cfcdf1db_38bb_4ecb_9d45_03bbc40b6b86
has only substance units: false
constant: false
is: SBO:0000297
name: DLD:GCSH:GLDC:AMT
initial concentration: NaN
initial amount: NaN
has part: P23434
type: Species
is encoded by: hsa:2731
has part: P48728
is encoded by: hsa:2653
has part: P23378
boundary condition: true
is encoded by: hsa:275

metaR FAS100COA
fast: false
reversible: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110034#
name: fatty acyl-CoA synthase (n-C10:0CoA)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110034#

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM ddcacoa m
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: C01832
is: HMDB03571
is: SBO:0000247
is: CHEBI:57375
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f4a72021_6112_4f42_b606_9659828f8691
initial amount: NaN
is: P43353
type: Species
is: SBO:0000252
initial concentration: NaN
name: ALDH3B1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110034#_39daa9ab_e9c0_4472_9d14_f880d9c36f96
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:144195
type: Species
name: SLC2A14
boundary condition: true
is: SBO:0000252
is: Q8TDB8
constant: false
has only substance units: false

metaM HC00342 m
is: SBO:0000247
is: CHEBI:16383
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
name: cis-aconitate(3-)
type: Species

metaR r0186
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reactant: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_94e7ae75_994b_4fcb_b73c_b70c2efb66df
initial amount: NaN
name: _AA278423_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA278423
has only substance units: false
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_e4be8d79_d960_4d7c_982d_61d93d71baeb
boundary condition: true
type: Species
name: SLC25A10
initial amount: NaN
is: Q9UBX3
has only substance units: false
is encoded by: hsa:1468
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_5ce26fd9_7b19_4194_9b0b_83b8bcbc3e49
type: Species
boundary condition: true
constant: false
name: CLYBL
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:171425
initial concentration: NaN
has only substance units: false

metaM akg m
is: C00026
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00208
is: CHEBI:16810
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-Oxoglutarate

http://identifiers.org/biomodels.db/MODEL1310110034#_09feb14c_ca4c_4bb1_ab31_1be4ab634b2e
initial amount: NaN
has only substance units: false
is encoded by: hsa:W87865
type: Species
name: _W87865_1_c
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR A MANASEly
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
name: alpha-mannosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.24

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
is: HMDB00968
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:58282

http://identifiers.org/biomodels.db/MODEL1310110034#_df3c6eb5_1879_4424_b156_48d854210811
type: Species
constant: false
name: SC5DL
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6309
is: Q6GTM5
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM core6 l
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
is: HMDB00143
type: Species

metaR NCNt
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110034#

metaM sarcs e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: sarcosine
type: Species
initial amount: NaN
is: CHEBI:15611
is: HMDB00271

http://identifiers.org/biomodels.db/MODEL1310110034#_b6a9aa26_2e9b_4ca2_acf4_160a18ddbbcb
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ADSL
is encoded by: hsa:158

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM tststerone r
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
boundary condition: false
is: HMDB00234
name: testosterone
is: CHEBI:17347
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_a015b7b9_6587_4a87_b863_051beb92a95e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10449
constant: false
initial concentration: NaN
is: P42765
type: Species
boundary condition: true
name: ACAA2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a8642949_3f36_4617_8e17_be86832e35aa
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4722
initial concentration: NaN
name: NDUFS3
is: O75489
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_88a0ff86_88e5_442f_b372_321c26bcf804
is: Q13454
is: SBO:0000252
initial amount: NaN
name: TUSC3
is encoded by: hsa:7991
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true

metaR r0545
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false
modifier: MODEL1310110034#

metaR PNTEH
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
name: Hydrolase Class ( RXN R02973)
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
reactant: MODEL1310110034#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_dcfe2b26_a77c_4555_be8b_34cff1a540c0
name: PIP4K2C
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B3KQV3
has only substance units: false
constant: false
type: Species
is encoded by: hsa:79837
is: SBO:0000252

metaM rnam c
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
is: SBO:0000247
is: CHEBI:15927
name: N-Ribosylnicotinamide
is: HMDB00855
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaM pnto R e
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB00210
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
name: (R)-Pantothenate

http://identifiers.org/biomodels.db/MODEL1310110034#_51d49bd5_f2e2_495c_b8af_6f6fb388617e
has only substance units: false
is: SBO:0000252
is: Q04760
initial amount: NaN
is encoded by: hsa:2739
constant: false
name: GLO1
type: Species
initial concentration: NaN
boundary condition: true

metaM 3aib c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:33094
boundary condition: false
is: HMDB02166
has only substance units: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
name: (S)-3-aminoisobutyric acid
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_7fa2e0aa_f2f8_4800_8305_15fafe0a9226
name: DCTD
boundary condition: true
is: P32321
is encoded by: hsa:1635
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR ACACT1x
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is described by: ECO:0000134
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reversible: false

metaR r2371
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110034#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_afbb9ba4_8866_42a7_94cf_0661bbe263af
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR AKGMALtm
name: alpha-ketoglutarate/malate transporter
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
reversible: true

metaR SO4t4 2
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110034#
name: sulfate transport via sodium symport
kinetic law: MODEL1310110034#

metaM HC01444 e
is: SBO:0000247
has only substance units: false
name: Galactosylglycerol
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:15754
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_c6f6c724_0839_4822_9f5d_f4400b7879a2
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: O43570
is encoded by: hsa:771
name: CA12

metaM gly m
initial amount: NaN
is: CHEBI:15428
boundary condition: false
type: Species
name: Glycine
has only substance units: false
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false
is: SBO:0000247
is: C00037
initial concentration: 1.0

metaM 5dpmev c
boundary condition: false
is: HMDB01090
is: SBO:0000247
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_37142a7b_6419_4ed9_808a_064be6d87e79
is encoded by: hsa:NOS2A
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: _NOS2A_1_c
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_84f93a9c_8a94_47c5_9d0a_04d44cdc2b9a
initial amount: NaN
is: Q8IW54
type: Species
is encoded by: hsa:5138
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PDE2A

metaR TYMSFt
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
reversible: false
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
name: Tyramine O-sulfate transport (diffusion)
is: SBO:0000185

metaR r1116
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
product: MODEL1310110034#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM 3aib e
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial concentration: 1.0
is: HMDB02166
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM pnto R c
type: Species
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
is: HMDB00210
initial amount: NaN
name: (R)-Pantothenate
is: CHEBI:7916
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_0f15d79e_72d4_4199_9452_b135f08f9bb6
is: SBO:0000252
is: A0PJJ9
type: Species
constant: false
initial amount: NaN
name: GGT7
boundary condition: true
is encoded by: hsa:2686
has only substance units: false
initial concentration: NaN

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185

metaR r1260
name: EC:6.2.1.3
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e366f4b7_be53_43a5_aa51_4e1bdaac9092
name: UROS
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7390
is: P10746
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR LINKDEG1ly
fast: false
type: Reaction
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110034#
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR DRPA
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
name: deoxyribose-phosphate aldolase

metaR S6TASE19ly
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reactant: MODEL1310110034#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaM ksi deg35 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 35
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
constant: false
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
boundary condition: false
initial amount: NaN
is: HMDB00143

metaR RE1810M
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1810
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000176

metaM idour e
has only substance units: false
initial concentration: 1.0
name: L-iduronate
is: CHEBI:21338
initial amount: NaN
is: SBO:0000247
is: HMDB02704
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
constant: false

metaM ahcys m
is: SBO:0000247
is: C00021
is: HMDB00939
has only substance units: false
is: CHEBI:16680
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
type: Species

metaR LEUKTRE4t
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: leukotriene E4 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110034#

metaR CO2tm
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
name: CO2 transport (diffusion), mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ecf91e27_99b8_4c96_b92e_9f53c42be85d
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2629
initial amount: NaN
initial concentration: NaN
name: GBA
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_64bfbaf7_9758_4484_8e1f_0892475e52fa
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: A8K0I1
initial concentration: NaN
type: Species
is encoded by: hsa:160851
name: DGKH
constant: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM gd1b hs g
has only substance units: false
name: GD1b
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28648
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaM thymd c
constant: false
type: Species
boundary condition: false
is: HMDB00273
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
is: SBO:0000247
name: Thymidine
is: CHEBI:17748
initial concentration: 1.0
is: C00214

metaR r2362
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is: SBO:0000185
fast: false

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
modifier: MODEL1310110034#
name: geranyltranstransferase

metaM phe L e
is: SBO:0000247
is: HMDB00159
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
type: Species
name: L-phenylalanine
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_dba53159_a336_45a4_9f49_199ada5d7948
name: SULT1A3
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:6818
is: SBO:0000252
constant: false

metaR MI1345PP
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110034#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.86

metaR r2066
reversible: false
product: MODEL1310110034#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR 4PYRDX
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: 4-Pyridoxal secretion
type: Reaction
product: MODEL1310110034#
fast: false

metaM gq1b hs e
type: Species
is: CHEBI:58115
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
name: GQ1b
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
initial concentration: 1.0
is: HMDB01397

metaM Ser Thr l
initial concentration: 1.0
boundary condition: false
is: HMDB00224
is: CHEBI:58190
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)

metaM gd1a hs g
boundary condition: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial amount: NaN
is: CHEBI:58397
is: SBO:0000247
initial concentration: 1.0
type: Species
name: N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_26ba6091_3cb5_494d_b2a9_2706333083be
type: Species
constant: false
name: VNN3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:55350

http://identifiers.org/biomodels.db/MODEL1310110034#_3b0ab7da_9d39_45c0_8dd9_dfc1c34d84b9
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: P35219
boundary condition: true
is: SBO:0000252
is encoded by: hsa:767
name: CA8

metaM urate x
is: CHEBI:17775
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
is: HMDB00289
name: Urate

metaR r2361
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaM 4ppcys m
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: HMDB01117
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:59458

metaM co e
constant: false
name: carbon monoxide
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17245
initial concentration: 1.0
boundary condition: false
is: HMDB01361
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaR RE3524R
name: RE3524
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_56500257_4b63_4556_988e_872415b40679
is encoded by: hsa:4645
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: MYO5B
is: Q9H6Y6
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e5944021_d281_4545_8986_3bada6b802f2
type: Species
is: SBO:0000252
name: GUK1
is encoded by: hsa:2987
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: Q16774

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM sebacid c
is: C08277
type: Species
name: sebacicacid
initial concentration: 1.0
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM acald m
is: SBO:0000247
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
name: acetaldehyde
is: CHEBI:15343
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_8566b53b_42e4_4b68_8235_9a53b07032d3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q5QPH3
initial concentration: NaN
type: Species
has only substance units: false
name: ACSS2
constant: false
is encoded by: hsa:55902

metaM 3mox4hpac m
is: CHEBI:28111
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
type: Species
is: SBO:0000247
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial amount: NaN
has only substance units: false
is: HMDB05175
constant: false
boundary condition: false
initial concentration: 1.0

metaR r2364
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110034#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_82ac7a2d_365d_4dbf_bd92_3161801e049c
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: O00219
is encoded by: hsa:3038
name: HAS3

metaM phe L c
is: HMDB00159
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: L-phenylalanine
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
is: SBO:0000247

metaM dhea r
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: CHEBI:28689
type: Species
is: HMDB00077
constant: false
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110034#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is described by: ECO:0000254
modifier: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM gq1b hs g
is: HMDB00220
initial amount: NaN
boundary condition: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
has only substance units: false
type: Species
is: C00249
name: GQ1b
is: SBO:0000247
constant: false
is: CHEBI:7896
initial concentration: 1.0

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r2363
reversible: true
reactant: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR BILIRUBtr
reversible: true
product: MODEL1310110034#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185

metaM CE5786 e
is: HMDB02710
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:27485
initial concentration: 1.0
name: kinetensin

metaR DM anth
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM malcoa c
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
initial amount: NaN
name: Malonyl-CoA
initial concentration: 1.0
is: CHEBI:57384
boundary condition: false
has only substance units: false
is: C00083
type: Species
is: HMDB01175

http://identifiers.org/biomodels.db/MODEL1310110034#_2dfc45cb_e6f9_4f70_bb82_0b0753a3d210
initial amount: NaN
initial concentration: NaN
name: NDUFB10
is: A8K761
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4716
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_87dc050a_2528_484b_9ea8_151b935c020b
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H77542
initial amount: NaN
constant: false
boundary condition: true
name: _H77542_1_c

metaR PROSTGH2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
product: MODEL1310110034#
name: Prostaglandin H2 transport
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
fast: false

metaM co c
is: HMDB01361
initial concentration: 1.0
name: carbon monoxide
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
is: SBO:0000247
has only substance units: false

metaR r2063
reactant: MODEL1310110034#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#

metaR NTD1
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
reactant: MODEL1310110034#
name: 5'-nucleotidase (dUMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction

metaR r2366
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#

metaR NDPK1n
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM akg x
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00208
name: 2-oxoglutarate(2-)
is: CHEBI:16810

metaM Ser Thr g
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
is: CHEBI:58336
boundary condition: false
is: HMDB00645
type: Species
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0

metaR H6ET3er
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.1
is: SBO:0000176

metaM glgchlo e
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
name: beta glucan-glycocholate complex
is: HMDB00725
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r2062
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#

metaR r0870
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.1.3.4
reactant: MODEL1310110034#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
fast: false

metaR r2365
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110034#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0191
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.24
is described by: ECO:0000000
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false

metaM xol7ah2 m
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: CHEBI:28047
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR CO2tp
kinetic law: MODEL1310110034#
name: CO2 peroxisomal transport
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
product: MODEL1310110034#

metaM idour c
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
boundary condition: false
is: CHEBI:21338
is: SBO:0000247
has only substance units: false
is: HMDB02704
name: L-iduronate
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_22320494_448c_4909_a3fc_3c6f68c4216c
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: DLAT
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q86YI5
is encoded by: hsa:1737

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
name: H transporter, endoplasmic reticulum
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
fast: false
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000

metaR NTD3
name: 5'-nucleotidase (dCMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ed0adeb3_6ea1_4ab7_aa6a_c8f79daa129c
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC23A1
has only substance units: false
is encoded by: hsa:9963
constant: false

metaR GGH 7DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110034#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
fast: false

metaR r2368
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_9646d1cc_e98a_4c0e_9668_b60713e51d3e
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:93034
is: Q96P26
type: Species
name: NT5C1B
has only substance units: false
initial amount: NaN
boundary condition: true

metaM dhf m
type: Species
constant: false
is: HMDB01056
has only substance units: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
name: dihydrofolate(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r0656
kinetic law: MODEL1310110034#
is: SBO:0000176
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reversible: false
product: MODEL1310110034#
is described by: ECO:0000000

metaR NTD4
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: 5'-nucleotidase (CMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
reversible: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000254

metaR r2064
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000

metaR CREATt4 2 r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110034#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_32043b4a_6a35_412b_a68c_3c19fcd5b5f1
initial amount: NaN
is: O94903
constant: false
boundary condition: true
is encoded by: hsa:11212
has only substance units: false
type: Species
name: PROSC
is: SBO:0000252
initial concentration: NaN

metaM 2amac c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
initial concentration: 1.0
boundary condition: false
name: 2-aminoacrylic acid
has only substance units: false
is: CHEBI:17123
is: HMDB03609
initial amount: NaN

metaR r1538
modifier: MODEL1310110034#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR ACALDt
fast: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
name: acetaldehyde reversible transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_e9c61eb3_ab47_4fb2_9959_3b316f00f4d1
name: CRAT
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: P43155
boundary condition: true
has only substance units: false
is encoded by: hsa:1384

metaR r0193
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reactant: MODEL1310110034#
type: Reaction
reversible: true
product: MODEL1310110034#
is: SBO:0000176
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a9e72b11_05d6_4d6a_bb8e_9dd944d91ce1
is: Q92781
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5959
name: RDH5
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8e639017_1f40_4325_9f66_7dd43b80692f
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P17568
is encoded by: hsa:4713
constant: false
boundary condition: true
type: Species
name: NDUFB7

metaR r2367
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_fccaee07_50ec_4cb5_9284_4c62bfb17e85
boundary condition: true
name: ADCY2
is: Q71UM8
initial amount: NaN
is encoded by: hsa:108
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR biomass reaction
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110034#
name: Generic human biomass reaction
product: MODEL1310110034#
reversible: false
is described by: ECO:0000134

metaM gq1b hs c
is: HMDB00220
is: CHEBI:7896
boundary condition: false
type: Species
name: GQ1b
initial amount: NaN
is: SBO:0000247
is: C00249
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
constant: false

metaR FAOXC12DCTc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR DM gncore2 g
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_60f6522b_5f32_4de9_9036_f3670147b056
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: GAPDHS
is encoded by: hsa:26330
constant: false
is: SBO:0000252
boundary condition: true
is: O14556

metaR Htg
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
is described by: ECO:0000000

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM acald c
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: acetaldehyde
constant: false
is: CHEBI:15343
is: HMDB00990
is: SBO:0000247

metaM 3sala c
name: 3-Sulfino-L-alanine
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:61085
constant: false
is: C00606
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_70460c7e_fac9_4f6b_a12b_28fead8eda8a
is: P28329
initial concentration: NaN
boundary condition: true
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false

metaR NTD5
modifier: MODEL1310110034#
name: 5'-nucleotidase (dTMP)
reversible: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#

metaR GBA
is: SBO:0000176
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
name: Glucosylceramidase

http://identifiers.org/biomodels.db/MODEL1310110034#_93e73fea_7ee1_4ee3_a683_1adefb309184
is: P24311
name: COX7B
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1349
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_aaa91373_0b1a_4e2d_b93e_7452e0d6dbd4
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: HPD
is encoded by: hsa:3242
initial concentration: NaN
is: B3KQ63

metaR r0655
is described by: ECO:0000000
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reactant: MODEL1310110034#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2

metaM uri e
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: CHEBI:16704
is: HMDB00296
type: Species
constant: false
boundary condition: false
name: Uridine
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9add7ed5_d510_4fcb_b012_e05825921c51
type: Species
constant: false
boundary condition: true
is: Q9Y227
name: ENTPD4
is: SBO:0000252
is encoded by: hsa:9583
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM c10dc x
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: sebacoyl carnitine
is: HMDB00651
has only substance units: false
constant: false

metaR r2369
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction

metaM fald e
is: CHEBI:16842
has only substance units: false
constant: false
name: formaldehyde
is: SBO:0000247
is: HMDB01426
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaR NTD6
fast: false
modifier: MODEL1310110034#
name: 5'-nucleotidase (dAMP)
is described by: ECO:0000134
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
reactant: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b17bc5e7_769e_4adf_aefd_ecea351a1791
boundary condition: true
has only substance units: false
is encoded by: hsa:6560
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC12A4
is: F5H066
is: SBO:0000252
type: Species

metaR ASPt6
is described by: ECO:0000269
modifier: MODEL1310110034#
product: MODEL1310110034#
name: L-aspartate transport via Na, H symport and K antiport
reversible: false
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR GGH 5DHFe
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110034#
reversible: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#

metaM cholate e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
is: HMDB00619
has only substance units: false
constant: false
is: CHEBI:29747
initial concentration: 1.0
type: Species
initial amount: NaN

metaR CSNATer
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110034#
name: carnitine O-acetyltransferase, endolasmic reticulum
reactant: MODEL1310110034#
reversible: true

metaR r0033
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#

metaM acald e
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15343
is: HMDB00990
is: SBO:0000247
name: acetaldehyde

metaM ksi deg1 l
name: keratan sulfate I, degradation product 1
initial concentration: 1.0
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: HMDB00174
boundary condition: false
is: SBO:0000247
is: CHEBI:18287
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR IDOURte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110034#
name: L-iduronate transport, extracellular
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaR r2061
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110034#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9822d3f2_aee0_425b_b1d2_f1298e53a121
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9162
is: O75912
initial amount: NaN
is: SBO:0000252
name: DGKI
boundary condition: true

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_5882a67c_e763_4b20_8ef3_b00e9a1f1368
is encoded by: hsa:53354
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PANK1
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_72521546_1a24_4c2b_99b9_74171ebccd5e
initial amount: NaN
is: SBO:0000252
name: AHCY
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:191
boundary condition: true
constant: false
is: B3KUN3

metaR DMNONCOACRNCPT1
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
name: DMNONCOACRNCPT1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true

metaR 5AOPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
name: 5-Aminolevulinate mitochondrial transport
fast: false
type: Reaction
is: SBO:0000185

metaM 4ppcys c
is: HMDB01117
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: CHEBI:59458
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: C04352
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_8e7a2876_6b13_4d63_8a48_6d76bbb11ac8
is: P31213
is: SBO:0000252
constant: false
is encoded by: hsa:6716
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SRD5A2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_e7170d69_3fc3_4024_885b_37b1ec0ba4c4
initial amount: NaN
type: Species
is: Q9H0P0
boundary condition: true
is encoded by: hsa:51251
is: SBO:0000252
initial concentration: NaN
name: NT5C3
constant: false
has only substance units: false

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true
is described by: ECO:0000000

metaR r2060
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#

metaR D 3AIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: D-3-amino-isobutyrate transport
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a67fe875_8a98_47ad_8243_c7bfd55e8033
is: B7Z5T8
has only substance units: false
initial amount: NaN
type: Species
name: CPT1B
is encoded by: hsa:1375
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR NTD8
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dGMP)
kinetic law: MODEL1310110034#
fast: false

metaM ksi deg38 l
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
name: keratan sulfate I, degradation product 38

metaR GGH 7THFe
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
name: Gamma-glutamyl hydrolase (7THF), extracellular
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
kinetic law: MODEL1310110034#

metaR MACACI
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110034#
name: maleylacetoacetate isomerase
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269

metaR S6TASE9ly
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000176

metaR r0651
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110034#

metaM cholate c
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: Cholate
is: HMDB00619
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:29747

metaR NTD9
modifier: MODEL1310110034#
is described by: ECO:0000134
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
product: MODEL1310110034#
name: 5'-nucleotidase (GMP)
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false

metaM fol e
constant: false
name: Folate
initial amount: NaN
boundary condition: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2aff6451_95b8_4da4_adf2_8a044199049c
constant: false
initial amount: NaN
has only substance units: false
is: Q86SK9
initial concentration: NaN
type: Species
name: SCD5
is: SBO:0000252
is encoded by: hsa:79966
boundary condition: true

metaM dodecanac c
has only substance units: false
is: HMDB00623
name: Dodecanedioic acid
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C12H20O4 CHARGE: -2
boundary condition: false

metaR r0879
reversible: false
product: MODEL1310110034#
fast: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#

metaR r1808
type: Reaction
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_3eff1dfa_5679_4666_b49f_9684acc77f77
is encoded by: hsa:51196
name: PLCE1
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q9P212

metaM 3dhguln c
has only substance units: false
is: CHEBI:57655
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: 3-dehydro-L-gulonate

metaM 5htrp c
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
constant: false
is: HMDB00472

metaR r0650
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
reversible: true

metaM fmn c
constant: false
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: HMDB01520
has only substance units: false
is: CHEBI:58210
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00061

metaR P4508B11r
is version of: http://identifiers.org/ec-code/1.14.13.95
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is: SBO:0000176
reactant: MODEL1310110034#
name: sterol 12-alpha-hydroxylase
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_f39050e9_23cc_48cb_8ed6_7477d7bb6938
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: Q7Z5T0
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6507
name: SLC1A3

http://identifiers.org/biomodels.db/MODEL1310110034#_530c2e6b_7d44_411b_ab5f_b1830567f4c3
type: Species
initial amount: NaN
constant: false
name: BCKDHB
is: P21953
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM acglcgalgluside hs g
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
initial amount: NaN
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
type: Species
has only substance units: false
is: CHEBI:17103
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_22887af2_532f_4b96_ac38_d4d3d7d0c4f0
constant: false
type: Species
is encoded by: hsa:51166
is: Q4W5N8
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: AADAT

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR r1809
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dnad c
initial amount: NaN
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: SBO:0000247
initial concentration: 1.0
is: C00857
has only substance units: false
is: CHEBI:18304
type: Species
boundary condition: false
name: Deamino-NAD+
is: HMDB01179
constant: false

metaR SERtN1
type: Reaction
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: Serine transport (Na, H coupled)

metaM gncore2 g
is: CHEBI:15876
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
constant: false
name: GlcNAc-alpha-1,4-Core 2
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_f3fb02f7_2b99_450c_b89d_6dce92a711b0
type: Species
is encoded by: hsa:AI378339
name: _AI378339_1_m
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134
reversible: true

metaR GLCAASE7ly
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
name: beta-glucuronidase, lysosomal
reversible: false
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
type: Reaction

metaM dgtp m
is: CHEBI:16497
is: SBO:0000247
is: C00286
is: HMDB01440
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species
initial concentration: 1.0
boundary condition: false

metaR LEUKTRA4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is described by: ECO:0000269
name: leukotriene A4 transport
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
type: Reaction

metaR TYRt4
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
name: L-tyrosine transport in via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110034#
fast: false
type: Reaction
reversible: false
product: MODEL1310110034#
is described by: ECO:0000304

metaR r1682
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
name: Y+LAT2 Utilized transport
reversible: false
fast: false
modifier: MODEL1310110034#

metaM gt1b hs g
initial amount: NaN
boundary condition: false
is: CHEBI:28058
type: Species
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
is: SBO:0000247
has only substance units: false
name: GT1b
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_dfc9135f_7049_4d68_a9d0_dab46195d5bb
type: Species
name: CDS2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: O95674
is encoded by: hsa:8760
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e057b8cd_230f_4789_b18b_4a8af76fb3b0
is encoded by: hsa:AL038231
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AL038231_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

metaM fol c
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
is: HMDB00121
has only substance units: false
is: SBO:0000247
type: Species
name: Folate

http://identifiers.org/biomodels.db/MODEL1310110034#_ee5769fd_ed80_4788_be52_85d26f58d267
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: CROT
is: E7EQF2
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:54677

metaR NRPPHRSULT
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is described by: ECO:0000269
modifier: MODEL1310110034#
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Norepinephrine Sulfotransferase

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
fast: false
is described by: ECO:0000269
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction

metaR r1806
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110034#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_07d647ec_5ee6_4e5d_a4f1_a223d9a7fd11
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:53
is: E9PCI1
initial amount: NaN
type: Species
boundary condition: true
name: ACP2
has only substance units: false

metaM idour l
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:21338
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02704
name: L-iduronate
constant: false

metaM dgtp n
has only substance units: false
name: dGTP
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16497
is: HMDB01440
type: Species
is: SBO:0000247
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110034#_5d264a44_0138_493b_bf0c_533c4dabf1df
initial amount: NaN
constant: false
has only substance units: false
name: NADSYN1
initial concentration: NaN
is encoded by: hsa:55191
boundary condition: true
is: SBO:0000252
is: Q6IA69
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_7b7a7987_303f_43b1_b4ac_825d1590eb7d
name: CTSA
is encoded by: hsa:5476
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: P10619
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_79f28086_1cb7_4441_8f80_c60dbb32c433
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:516
boundary condition: true
is: SBO:0000252
is: Q6FIH7
constant: false
type: Species
name: ATP5G1
has only substance units: false

metaR HIStN1
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
name: Histidine transport (Na, H coupled)
reversible: true

metaM fald c
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
has only substance units: false
name: formaldehyde
boundary condition: false
is: CHEBI:16842
is: SBO:0000247
is: HMDB01426
constant: false
initial concentration: 1.0
initial amount: NaN

metaM xyl D l
constant: false
is: CHEBI:15936
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
name: aldehydo-D-xylose
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2fdfb5d9_9b9f_4fde_990d_b735e072f176
is: SBO:0000252
type: Species
name: SMPD3
constant: false
initial amount: NaN
is encoded by: hsa:55512
initial concentration: NaN
is: Q9NY59
boundary condition: true
has only substance units: false

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
initial amount: NaN
type: Species
is: CHEBI:16953
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: HMDB00812
has only substance units: false
initial concentration: 1.0
constant: false

metaM hs deg4 l
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
boundary condition: false
has only substance units: false
is: CHEBI:16126
name: heparan sulfate, degradation product 4
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_45a70d6e_4571_479f_8c21_c9d6fd63e198
has only substance units: false
is encoded by: hsa:AF116616
constant: false
is: SBO:0000252
name: _AF116616_1_m
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_c337a3a8_78ed_401e_858f_e2ee70fa133b
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GALNT12
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:79695
is: Q8IXK2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_cb369907_259b_42b6_a3e2_541bdc2898dc
is encoded by: hsa:6391
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q99643
name: SDHC
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM pail4p hs n
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58178
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110034#_5eaa4891_28b8_41b4_a89f_ed0d65b089d0
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:4513
constant: false
name: COX2
is: Q7GXZ8
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_3b0befe6_d39d_4b28_b248_bc938be3a26a
initial concentration: NaN
is encoded by: hsa:3284
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: P26439
boundary condition: true
is: SBO:0000252
name: HSD3B2

metaR H2Otg
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
name: H2O transport, Golgi apparatus

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaM acgam r
boundary condition: false
name: N-acetyl-D-glucosamine
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
constant: false
type: Species
is: HMDB00215
initial concentration: 1.0
is: CHEBI:17411
initial amount: NaN

metaM fadh2 m
is: CHEBI:58307
is: C01352
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: HMDB01197
name: Flavin adenine dinucleotide reduced

metaR RE0935E
is: SBO:0000176
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
kinetic law: MODEL1310110034#
type: Reaction

metaR CYTK9
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dCTP)
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_2118c951_3f38_406a_b811_52ae684cfc5e
constant: false
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:7991
boundary condition: true

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00508
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: D-ribitol

metaR S6TASE21ly
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false

metaM occoa x
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
is: CHEBI:57386
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: HMDB01070
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_35ca595c_0390_4d0f_bbf2_f16242aa4efc
is encoded by: hsa:7108
is: O76062
name: TM7SF2
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR FATP1t
product: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110034#_7f7e655e_55c1_4a06_86ea_39fc79deaa89
is encoded by: hsa:23533
boundary condition: true
initial amount: NaN
name: PIK3R5
type: Species
is: SBO:0000252
is: Q8WYR1
has only substance units: false
constant: false
initial concentration: NaN

metaM ksi deg21 l
boundary condition: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
name: keratan sulfate I, degradation product 21
type: Species
has only substance units: false
is: HMDB00143
constant: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0

metaR PPAn
type: Reaction
reversible: false
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
name: inorganic diphosphatase, nuclear
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_48b86eed_b28f_4e90_bd4a_395fcde01270
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: HK1
is: P78542
is encoded by: hsa:3098
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR GLXO1
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
name: glyoxylate oxidase
reversible: false

metaR r1259
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
type: Reaction
name: EC:6.2.1.3
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_dec8e7d5_5dee_4e3f_bc82_1bbf7affa008
has only substance units: false
is: Q9H008
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: LHPP
constant: false
is encoded by: hsa:64077
type: Species
initial amount: NaN

metaM HC02207 c
is: SBO:0000247
is: CHEBI:27555
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: prostaglandin-c2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false

metaR r0838
type: Reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000185
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is described by: ECO:0000000

metaM hs deg8 l
type: Species
is: CHEBI:16126
boundary condition: false
name: heparan sulfate, degradation product 8
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f56bb99d_6a7e_4206_9c7c_c54841b56873
is: Q9HBF5
boundary condition: true
is encoded by: hsa:400410
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ST20
type: Species

metaM bhb m
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:10983
initial concentration: 1.0
is: HMDB00011
name: (R)-3-hydroxybutyrate

metaM pro L m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: L-proline
is: CHEBI:17203
boundary condition: false
is: HMDB00162
constant: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR ACP1 FMN
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reversible: false
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
name: acid phosphatase (FMN)
product: MODEL1310110034#

metaR PRGSTRNt
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: Progesterone transport
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_11ca53cd_dbc3_43d2_8874_7d57e1e5537c
is encoded by: hsa:23556
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PIGN
constant: false

metaM rbt c
has only substance units: false
initial concentration: 1.0
is: CHEBI:15963
type: Species
boundary condition: false
is: HMDB00508
constant: false
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
is: SBO:0000247

metaM gthox m
boundary condition: false
is: HMDB03337
is: CHEBI:58297
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0839
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110034#
name: Postulated transport reaction
fast: false
reversible: true
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.1.70

metaM thr L c
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
initial concentration: 1.0
name: L-threonine
is: SBO:0000247
type: Species
is: HMDB00167
boundary condition: false
is: CHEBI:16857
initial amount: NaN

metaR CYTK6
name: cytidylate kinase (CMP,CTP)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110034#
reversible: true
fast: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM fadh2 r
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: HMDB01197
constant: false
name: FADH2(2-)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_4cbd7b78_036b_4f02_9494_91ad72932981
is: SBO:0000252
is: Q06830
initial amount: NaN
initial concentration: NaN
name: PRDX1
constant: false
type: Species
boundary condition: true
is encoded by: hsa:5052
has only substance units: false

metaM arachcoa e
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: arachidyl coenzyme A
has only substance units: false
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258

metaR r0559
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110034#
modifier: MODEL1310110034#

metaR r0836
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110034#
type: Reaction

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15372
type: Species
constant: false
is: HMDB00027
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272

metaR CYSTALArBATtc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM hyptaur c
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00965
name: Hypotaurine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: CHEBI:16668
type: Species
has only substance units: false

metaR CYTK5
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110034#
fast: false
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110034#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110034#
reversible: true

metaM ac e
initial amount: NaN
is: SBO:0000247
type: Species
name: acetate
is: CHEBI:30089
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00042

metaR SUBEACTD
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ea73c8e9_7e45_4d1c_ba2b_1760e2b0b192
has only substance units: false
name: NDUFV3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4731
constant: false
initial concentration: NaN

metaM nadph x
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
is: SBO:0000247
is: HMDB00221
is: CHEBI:57783
is: C00005
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_33b9e89b_f628_4ab3_b42c_b5c74b9df864
is encoded by: hsa:AI915649
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AI915649_1_c
type: Species

metaR C160CPT1
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
name: production of Palmitoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110034#_85d4e2b5_48c5_4103_9ec3_63c9c8b3c3e0
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9Y2D0
type: Species
initial concentration: NaN
is encoded by: hsa:11238
name: CA5B

metaM ksii core4 deg3 l
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
name: keratan sulfate II (core 4-linked), degradation product 3
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00143
initial concentration: 1.0
type: Species

metaM Rtotal2 e
has only substance units: false
is: HMDB00244
initial amount: NaN
is: CHEBI:3554
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
name: R total 2 position
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b69bd380_5b5b_4e97_8894_7194a70101fa
is: P07195
type: Species
name: LDHB
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3945
constant: false

metaR CYTK6n
name: cytidylate kinase (CMP,CTP),nuclear
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
is: SBO:0000176
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR CYTK8
modifier: MODEL1310110034#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110034#
name: cytidylate kinase (CMP,dATP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8e1d85b2_2f25_41cd_8849_77175c7fe3cc
has only substance units: false
name: TUSC3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7991
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaM thr L e
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00167
type: Species
name: L-threonine
is: CHEBI:16857
initial amount: NaN
boundary condition: false

metaM 3odcoa x
constant: false
initial concentration: 1.0
is: CHEBI:28528
has only substance units: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
type: Species
initial amount: NaN
name: 3-Oxodecanoyl-CoA
is: HMDB03939
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_1e0f95fd_aa90_4a19_b42f_f781e8d4949c
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:53919
initial amount: NaN
has only substance units: false
type: Species
is: Q5JPA4
name: SLCO1C1
initial concentration: NaN

metaR r0400
type: Reaction
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

metaR r0834
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true

metaM pi x
initial amount: NaN
name: hydrogenphosphate
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0

metaR RE2541E
type: Reaction
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110034#
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
fast: false
name: RE2541
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reactant: MODEL1310110034#

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110034#
name: cytidylate kinase (CMP,UTP)

http://identifiers.org/biomodels.db/MODEL1310110034#_63431b86_dc41_4568_b1d5_09d4dfe51db4
boundary condition: true
is: SBO:0000252
constant: false
name: CROT
type: Species
is encoded by: hsa:54677
has only substance units: false
initial concentration: NaN
is: E7EQF2
initial amount: NaN

metaM decdicoa c
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: decadienoylcoa
is: HMDB01168
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR RE1796M
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
product: MODEL1310110034#
name: RE1796
reactant: MODEL1310110034#
type: Reaction
reversible: true

metaM Rtotal2 c
is: SBO:0000247
is: CHEBI:60377
initial amount: NaN
constant: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
is: HMDB00095
is: C00055
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_65875f28_d3d8_44c9_9fc0_f18a96e8a6ab
name: FOLR1
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2348
has only substance units: false

metaR r0835
modifier: MODEL1310110034#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR ADPCOAPTE
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR S6TASE26ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110034#

metaR CYTK1
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110034#
name: cytidylate kinase (CMP)

http://identifiers.org/biomodels.db/MODEL1310110034#_9ae0d2f6_5a28_48ec_b4eb_4b3cb7d6babe
is: SBO:0000252
is encoded by: hsa:6240
is: P23921
type: Species
constant: false
has only substance units: false
name: RRM1
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM 4mop e
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial amount: NaN
is: CHEBI:17865
boundary condition: false
is: HMDB00695
name: 4-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110034#_810d7625_2c53_4dd4_ba18_c75d5f10b618
is: SBO:0000252
is: P27987
initial amount: NaN
is encoded by: hsa:3707
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: ITPKB

metaM cs a deg4 l
is: SBO:0000247
initial amount: NaN
is: HMDB00812
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
constant: false
is: CHEBI:16953
initial concentration: 1.0
boundary condition: false

metaM xoldiolone r
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
is: HMDB02197
is: CHEBI:28477
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a9579b46_6bc5_4461_acf8_4a78b23d8016
has only substance units: false
name: CA1
is: P00915
type: Species
is encoded by: hsa:759
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM HC01376 m
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28692
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: S-(2-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118

metaR r0616
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_4f2d2e73_e4c1_4b97_9c25_ea7c78493c2b
is encoded by: hsa:AI435857
initial amount: NaN
boundary condition: true
name: _AI435857_1_x
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_8c91768f_8cad_48c7_aa15_cbb154e7973d
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFS1
is: SBO:0000252
is encoded by: hsa:4719
constant: false
has only substance units: false
is: P28331

metaM dolmanp U c
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human uterine homolog
is: CHEBI:15809

metaR ADNK1m
is: SBO:0000176
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false
name: adenosine kinase, mitochondrial
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
fast: false

metaM Lcystin c
boundary condition: false
initial concentration: 1.0
is: HMDB00192
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
name: L-cystine
is: CHEBI:16283
constant: false
initial amount: NaN
is: SBO:0000247

metaR NADPHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110034#
type: Reaction
reversible: false

metaR q10tm
reversible: true
name: transport of ubiquinone into mitochondria
reactant: MODEL1310110034#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r0556
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false

metaR NACHEX3ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110034#
is described by: ECO:0000000
fast: false

metaR r0009
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
fast: false
reversible: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
is: SBO:0000176

metaR r0403
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_f8a093d6_2e28_40f6_9a77_c184a1cc7fe5
is: SBO:0000252
initial concentration: NaN
constant: false
name: DHCR24
type: Species
has only substance units: false
is encoded by: hsa:1718
is: Q15392
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_fc7d9eb1_4979_4270_8604_26f6dd5ae7ee
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:506
constant: false
is: P06576
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ATP5B

metaM lnlncgcoa c
is: HMDB06368
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
is: SBO:0000247
type: Species

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR RNDR2
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (GDP)
fast: false
product: MODEL1310110034#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
reactant: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_0369c320_6355_4ad8_a85d_7d2136d0336b
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: P35557
constant: false
name: GCK
has only substance units: false
is encoded by: hsa:2645

metaR r2384
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaM no c
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: C00533
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
initial concentration: 1.0
name: Nitric oxide
is: SBO:0000247
is: CHEBI:16480

metaR r0618
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110034#
reversible: true

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM 4mop c
is: HMDB00695
initial concentration: 1.0
boundary condition: false
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110034#
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaM Lcystin e
boundary condition: false
initial concentration: 1.0
is: HMDB00192
type: Species
has only substance units: false
is: CHEBI:16283
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
name: L-cystine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_1af43fa3_c4d1_4fa5_b9ea_cad820bc8db7
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:117248
has only substance units: false
is: SBO:0000252
name: GALNTL2
type: Species
is: Q8N3T1
initial concentration: NaN

metaR RNDR1
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: false
fast: false
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000254

metaR 4NPHSULT
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: 4-Nitrophenol Sulfotransferase
modifier: MODEL1310110034#
reversible: false
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_3db89aea_22b8_4786_b289_92209d6b0f42
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5279
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PIGC

metaR CYTK4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
name: cytidylate kinase (dCMP)(GTP)
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM guln c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
boundary condition: false
initial concentration: 1.0
is: CHEBI:13115
initial amount: NaN
has only substance units: false
name: L-gulonate

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
reversible: true
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR VALTAm
type: Reaction
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: valine transaminase, mitochondiral

http://identifiers.org/biomodels.db/MODEL1310110034#_4f7da4a3_2913_41d6_9399_5dd47d7b2540
name: RRM2B
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q7LG56
is encoded by: hsa:50484
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_8d84b824_3ae3_4964_bdca_d9f534dc98bf
name: _AI620219_1_e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI620219
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR CYTK2
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110034#
is described by: ECO:0000269

metaR PPNCL3
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110034#
name: phosphopantothenate-cysteine ligase
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaM 4fumacac c
constant: false
has only substance units: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18034
is: HMDB01268
name: 4-fumarylacetoacetate(2-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_2598be13_96bb_49b6_87f7_0532b8402db6
is encoded by: hsa:137872
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: ADHFE1
is: SBO:0000252
is: Q8IWW8

metaR r0558
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110034#

metaR r2382
is: SBO:0000185
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000

metaM acgam l
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00215
is: CHEBI:17411
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
boundary condition: false
is: SBO:0000247

metaM nadph r
is: HMDB00221
is: C00005
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57783
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
has only substance units: false

metaR CYTK3
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110034#

metaM CE0693 m
type: Species
name: 3-oxolaur-6-cis-enoyl-CoA
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
constant: false
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB11123

metaR NDP7er
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
type: Reaction
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_f4406c58_486e_4afa_85a1_9fa9446e45e4
has only substance units: false
is: SBO:0000252
name: AGPAT3
boundary condition: true
type: Species
constant: false
is: Q9NRZ7
is encoded by: hsa:56894
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9d08ea18_e07c_47b0_8fa9_8ea5f6d01b1e
name: SLC25A19
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9HC21
is encoded by: hsa:60386

metaM bhb e
name: (R)-3-hydroxybutyrate
is: SBO:0000247
is: CHEBI:10983
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0

metaR r1148
is: SBO:0000185
reactant: MODEL1310110034#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
type: Reaction

metaR EX 3ivcrn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_928227e2_bd41_40dc_aef0_b21186e2e91e
constant: false
initial concentration: NaN
has only substance units: false
name: SYNJ2
initial amount: NaN
type: Species
is: SBO:0000252
is: O15056
is encoded by: hsa:8871
boundary condition: true

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_dfcd7435_888f_45c2_ab9c_88dd5a604d72
is: B3KUV7
type: Species
initial amount: NaN
is encoded by: hsa:5277
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: PIGA

http://identifiers.org/biomodels.db/MODEL1310110034#_3cc38ad8_26e3_415c_a735_4cdbe9128fc4
constant: false
is encoded by: hsa:9057
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has part: Q92536
boundary condition: true
has only substance units: false
name: SLC3A2:SLC7A6

metaM bhb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
is: HMDB00011
is: SBO:0000247
type: Species
is: CHEBI:10983
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1147
reversible: true
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR r1252
product: MODEL1310110034#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: EC:6.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM pi r
name: hydrogenphosphate
type: Species
is: C00009
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB00973
is: CHEBI:43474

metaR r2380
product: MODEL1310110034#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110034#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM gm1b hs g
initial amount: NaN
is: CHEBI:15440
is: HMDB00256
constant: false
name: GM1b
type: Species
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM ac m
name: acetate
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30089
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
type: Species

metaM 5hoxindoa c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00763
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
name: 5-Hydroxyindoleacetate
is: CHEBI:27823
is: SBO:0000247
constant: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR r0552
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
modifier: MODEL1310110034#

metaM nadph m
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
has only substance units: false
is: HMDB00221
initial concentration: 1.0
type: Species
is: C00005
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM 5dhf e
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: pentaglutamyl folate (DHF)
is: HMDB06487
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_088568f1_37f6_4228_9973_7fe2a7881cdb
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:217
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: P05091
name: ALDH2
has only substance units: false

metaM grdp x
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: CHEBI:58057
has only substance units: false
initial concentration: 1.0
name: geranyl diphosphate(3-)
is: HMDB01285
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaM pacald c
name: phenylacetaldehyde
is: CHEBI:16424
is: HMDB06236
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_9080a7fe_968b_4dfe_b460_b647cb1c1d93
boundary condition: true
has only substance units: false
constant: false
name: GGT5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P36269
is encoded by: hsa:2687
type: Species

metaR r0408
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
kinetic law: MODEL1310110034#
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_030d21c8_67fb_4772_a5c1_886a1d5f1679
name: CPT1B
is encoded by: hsa:1375
boundary condition: true
is: SBO:0000252
is: Q53FV7
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_de191a41_5d8f_4cd7_a863_266c626d9564
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: PAICS
is encoded by: hsa:10606
initial concentration: NaN
is: P22234
boundary condition: true
has only substance units: false

metaM succoa x
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01022
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR MALtm
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000269
fast: false
name: malate transport, mitochondrial
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true

metaR r0553
is: SBO:0000176
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaR C12DCTD
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_04cd71d4_8f9b_4f19_84c2_395757996842
type: Species
boundary condition: true
is: P17752
constant: false
initial concentration: NaN
is encoded by: hsa:7166
name: TPH1
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR 3MOPt2im
fast: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110034#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR r0409
is described by: ECO:0000000
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false

metaM ptth m
is: CHEBI:16753
is: SBO:0000247
is: HMDB03426
has only substance units: false
constant: false
name: pantetheine
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r0196
reactant: MODEL1310110034#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110034#

metaM pi n
name: hydrogenphosphate
initial concentration: 1.0
constant: false
is: HMDB00973
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
has only substance units: false
is: CHEBI:43474
is: SBO:0000247
initial amount: NaN

metaM cytd m
name: cytidine
is: SBO:0000247
boundary condition: false
is: HMDB00089
initial amount: NaN
type: Species
is: CHEBI:17562
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
initial concentration: 1.0

metaM HC02204 c
has only substance units: false
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: prostaglandin-b1

metaR INSt
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Inosine transport (diffusion)

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR DAGt
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110034#
name: diacylglycerol transport
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110034#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM icit x
is: HMDB00193
initial concentration: 1.0
name: isocitrate(3-)
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#

metaR r0774
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_5af63eb0_5f2b_4f13_be98_ca721d943065
is encoded by: hsa:513
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:514
has only substance units: false
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
boundary condition: true

metaM dlnlcgcoa c
constant: false
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM pi m
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: C00009
initial amount: NaN
constant: false
is: CHEBI:43474
name: hydrogenphosphate
initial concentration: 1.0
type: Species
is: HMDB00973
has only substance units: false

metaM prostge2 c
name: prostaglandin E2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:606564
is: HMDB01220
has only substance units: false
constant: false
type: Species

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR GALASE17ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110034#_2d9e50a5_a3f7_4349_8b4b_b273a26a1edd
name: PDE8A
initial concentration: NaN
is encoded by: hsa:5151
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR r2379
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
reactant: MODEL1310110034#

metaR RTOTALt
name: RTOTAL transport
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR BMTer U
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
product: MODEL1310110034#
modifier: MODEL1310110034#
name: B mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000

metaM itaccoa m
boundary condition: false
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
type: Species
initial amount: NaN
has only substance units: false
is: HMDB03377
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_25836987_c748_495e_86f2_f8b484717174
initial amount: NaN
boundary condition: true
name: _T83654_1_e
is: SBO:0000252
is encoded by: hsa:T83654
type: Species
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_925a2eee_06d5_4eee_a30a_bf2a7a7f24b6
initial amount: NaN
initial concentration: NaN
is: Q9NTN3
is encoded by: hsa:23169
type: Species
name: SLC35D1
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR CDPDAGtm
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
type: Reaction

metaR FACOAL204
fast: false
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110034#
reversible: true

metaR PPItx
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Diphosphate transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b87b9e56_4930_4981_8fc5_46670f59c9bc
type: Species
constant: false
initial amount: NaN
is: P21912
name: SDHB
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6390

metaR r1418
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_382d69e4_fbc4_4bc4_9286_c5e5974ad2d3
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:55350
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: VNN3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_02bb10a7_71f7_441a_8640_da3e07a16573
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: P16278
is encoded by: hsa:2720
constant: false
initial amount: NaN
name: GLB1

http://identifiers.org/biomodels.db/MODEL1310110034#_35716e3e_1848_418c_ab69_fe7501507dad
is encoded by: hsa:AI694761
constant: false
name: _AI694761_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaM tetdece1crn c
is: HMDB02014
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
name: tetradecenoyl carnitine

metaM retinal c
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: retinal
is: CHEBI:15035
is: HMDB01358
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM atp x
is: SBO:0000247
is: HMDB00538
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: ATP(4-)
is: C00002
is: CHEBI:57299
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_d7555da6_a5e7_4bc3_86a8_659bbfc983db
initial amount: NaN
has only substance units: false
name: UROD
is: SBO:0000252
is encoded by: hsa:7389
constant: false
type: Species
boundary condition: true
is: P06132
initial concentration: NaN

metaR PYRt2m
name: pyruvate mitochondrial transport via proton symport
fast: false
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR DURIK1
reversible: false
is: SBO:0000176
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.1.21
name: deoxyuridine kinase (ATP:Deoxyuridine)
type: Reaction
fast: false
kinetic law: MODEL1310110034#

metaM didp n
is: HMDB03536
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
constant: false
boundary condition: false
name: dIDP
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r2377
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#

metaR S6TASE12ly
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR GLYCtm
reversible: true
reactant: MODEL1310110034#
name: glycerol transport
fast: false
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110034#

metaR CSPG Btly
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: chondroitin sulfate B transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction

metaR r0995
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

metaM leuktrF4 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB06465
initial concentration: 1.0
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
has only substance units: false
is: CHEBI:27491
name: leukotriene F4

http://identifiers.org/biomodels.db/MODEL1310110034#_5e784383_e151_46c1_9562_2387a7d0c78b
boundary condition: true
constant: false
type: Species
is encoded by: hsa:50700
name: RDH8
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NYR8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_db6ef317_c42a_4038_95bd_52f277eef3bb
name: ACSS2
boundary condition: true
is: SBO:0000252
is: Q5QPH3
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:55902
initial amount: NaN
has only substance units: false

metaM tststerone e
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
boundary condition: false
name: testosterone
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00234
is: CHEBI:17347
constant: false

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110034#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_4cfc0c53_d4c0_4ada_b25e_feda33d75fe4
is encoded by: hsa:AI924226
name: _AI924226_1_m
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM arg L e
name: L-argininium(1+)
is: CHEBI:32682
constant: false
has only substance units: false
boundary condition: false
is: HMDB00517
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247

metaR NDPK2n
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
fast: false
is: SBO:0000176

metaM 13dpg c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: C00236
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
name: 3-Phospho-D-glyceroyl phosphate

metaR HACD1m
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
reversible: true

metaM lnlccoa m
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: linoleic coenzyme A
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
type: Species

metaM ptth c
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
type: Species
name: pantetheine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16753

metaM pail4p hs c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
is: CHEBI:58178
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR GALt4
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
name: galactose transport via sodium symport
product: MODEL1310110034#
type: Reaction
reversible: true
fast: false
is: SBO:0000185

metaR HSPGtly
product: MODEL1310110034#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110034#

metaM val L m
is: HMDB00883
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16414
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM amet m
type: Species
name: S-Adenosyl-L-methionine
is: HMDB01185
is: CHEBI:15414
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00019

metaM homoval m
is: HMDB00118
is: CHEBI:545959
constant: false
is: SBO:0000247
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial amount: NaN
name: Homovanillate
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_94045202_f855_4fad_905f_3ef12d9d85ac
is encoded by: hsa:8526
constant: false
is: A1L4Q0
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DGKE

metaR r2375
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

metaR DHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
name: dihydrofolate reversible mitochondrial transport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_13895a91_90cf_4eac_b401_ba9abdf55bdb
initial concentration: NaN
is encoded by: hsa:8875
is: A8K7W0
type: Species
name: VNN2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM HC01180 c
constant: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58694

http://identifiers.org/biomodels.db/MODEL1310110034#_756eb22b_a7e3_4b55_83f7_1fb76a19c01c
initial concentration: NaN
constant: false
name: ACOT7
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11332
is: O00154
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_481cb249_4698_42bf_9b6e_09b05b30a7e5
is: SBO:0000252
boundary condition: true
constant: false
is: O75251
type: Species
name: NDUFS7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:374291
has only substance units: false

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C01602
is: CHEBI:0
boundary condition: false
name: Ornithine

http://identifiers.org/biomodels.db/MODEL1310110034#_c86d0512_af53_4065_8013_3139283f75bf
name: BLVRA
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: P53004
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:644

metaM ipdp c
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: C00129
name: Isopentenyl diphosphate
is: SBO:0000247
is: HMDB01347
boundary condition: false
is: CHEBI:128769
initial concentration: 1.0

metaR CYSSNAT5tc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RE2651R
type: Reaction
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2651
is described by: ECO:0000000
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_0468d237_2aea_49c7_9811_0a3b0d48707e
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3948
name: LDHC
initial amount: NaN

metaM ddece1crn e
is: SBO:0000247
boundary condition: false
type: Species
name: dodecenoyl carnitine
is: HMDB02250
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false

metaR r2374
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_3a2d74d5_4152_4613_abda_88a4e170addb
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:4702
is: B1AM93
constant: false
type: Species
name: NDUFA8
is: SBO:0000252

metaR r0627
product: MODEL1310110034#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reactant: MODEL1310110034#

metaM lgt S c
name: (R)-S-lactoylglutathionate(1-)
constant: false
is: HMDB01066
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
has only substance units: false
is: CHEBI:57474

metaR DGSNt
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: deoyguanosine transport via diffusion

metaR r2079
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_d8001100_ed28_4a11_b874_61d723b8ad93
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: NDUFA13
is: Q9P0J0
is encoded by: hsa:51079

metaM fadh2 c
initial concentration: 1.0
is: CHEBI:58307
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: HMDB01197
is: SBO:0000247

metaR PIter
name: phosphate transport, endoplasmic reticulum
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000212
kinetic law: MODEL1310110034#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

metaR r1929
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Y+LAT2 Utilized transport

metaR SFGTH
name: S-Formylglutathione hydralase
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.12
fast: false
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_89695e33_9d6f_4879_ad57_c2760159d987
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q4G1C4
is encoded by: hsa:284273
constant: false
name: ZADH2
initial concentration: NaN
has only substance units: false

metaM ddece1crn c
name: dodecenoyl carnitine
has only substance units: false
initial concentration: 1.0
is: HMDB03712
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0

metaR r2373
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true

metaM prostge2 e
initial concentration: 1.0
type: Species
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
is: HMDB01220
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: prostaglandin E2(1-)

metaR r0002
kinetic law: MODEL1310110034#
name: Active transport
type: Reaction
product: MODEL1310110034#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is described by: ECO:0000000

metaM 4aphdob c
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58147
is: HMDB00978
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_39dedf24_e8fb_41d9_a271_98a40603cdde
constant: false
is: Q96HD9
is encoded by: hsa:91703
type: Species
boundary condition: true
name: ACY3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM pi g
is: CHEBI:43474
initial concentration: 1.0
constant: false
name: hydrogenphosphate
is: HMDB00973
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR TTDCAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110034#
name: tetradecanoate (transport)
type: Reaction
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000269

metaR r0999
is: SBO:0000185
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_df0c3fd9_cea1_41ad_973a_42d59090ac36
is: SBO:0000252
name: ATP5E
initial amount: NaN
is: P56381
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:514

metaM CE2418 m
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28387
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA

metaR PPItr
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Diphosphate transporter, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#

metaM pail34p hs c
initial amount: NaN
initial concentration: 1.0
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
has only substance units: false
boundary condition: false
is: CHEBI:57658
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
constant: false

metaR ADSL2
type: Reaction
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
is described by: ECO:0000269
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
name: adenylosuccinate lyase

metaM atp r
name: ATP(4-)
is: CHEBI:57299
is: SBO:0000247
constant: false
boundary condition: false
is: C00002
initial amount: NaN
initial concentration: 1.0
is: HMDB00538
has only substance units: false
type: Species

metaM fucgalacglcgalgluside hs g
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01167
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
is: CHEBI:17158
name: Type IH glycolipid
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_4fd5feab_67a7_49a6_b5e9_6e98d39862b8
has only substance units: false
constant: false
is encoded by: hsa:8897
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: MTMR3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_5193146e_1f7d_4927_bd14_a4287db47f82
is encoded by: hsa:2348
has only substance units: false
boundary condition: true
constant: false
type: Species
name: FOLR1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_41ea6c41_bac4_4adf_9762_2ffe5034559d
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: O75489
name: NDUFS3
initial amount: NaN
is encoded by: hsa:4722
boundary condition: true
is: SBO:0000252

metaM pect e
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: pectins
is: SBO:0000247
boundary condition: false
is: HMDB03402
initial concentration: 1.0
notes: FORMULA: C2535H3509O2535 CHARGE: -1

metaM ksi deg8 l
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 8
has only substance units: false
type: Species
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial concentration: 1.0

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r0990
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110034#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction

metaR RETt
reversible: false
reactant: MODEL1310110034#
name: Retinol transport via faciliated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction

metaM nadph c
boundary condition: false
type: Species
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
initial amount: NaN
has only substance units: false
is: HMDB00221

metaM pi e
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: C00009
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:43474
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110034#_113f92af_1e1b_47da_a842_ff80a74145f4
constant: false
initial amount: NaN
name: GGT3P
is encoded by: hsa:2679
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_fba9fb16_945b_461f_93b1_ea442184c930
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: MECR
is: Q9BV79
has only substance units: false
is encoded by: hsa:51102
is: SBO:0000252

metaM hs deg20 l
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16126
boundary condition: false
type: Species
name: heparan sulfate, degradation product 20

metaM ksi e
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate I
is: HMDB00211
initial concentration: 1.0
is: CHEBI:17268
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false

metaR SUCCCROT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaM ac c
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
name: acetate
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:30089
boundary condition: false
is: HMDB00042
initial concentration: 1.0

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaM ksi deg4 l
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 4
initial concentration: 1.0
type: Species
is: HMDB00868
constant: false
is: CHEBI:57737
has only substance units: false
is: SBO:0000247

metaR ALAGLYexR
modifier: MODEL1310110034#
name: L-alanine/glycine reversible exchange
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000304

metaR MALTe
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: alpha-glucosidase, extracellular
fast: false
kinetic law: MODEL1310110034#

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
reactant: MODEL1310110034#

metaM arg L c
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:32682
type: Species
is: HMDB00517
constant: false
name: L-argininium(1+)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_48a94321_8b24_42dd_a10e_1ae935036f62
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4536
type: Species
is: Q7GXY9
has only substance units: false
name: ND2
initial concentration: NaN

metaM cytd c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
name: Cytidine
has only substance units: false
type: Species
constant: false
is: CHEBI:17562
is: SBO:0000247
initial amount: NaN
is: HMDB00089
is: C00475

metaM tststerone c
is: CHEBI:17347
is: SBO:0000247
is: HMDB00234
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
initial amount: NaN
type: Species
name: testosterone

metaM pi c
is: C00009
name: hydrogenphosphate
is: HMDB00973
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:43474

metaR r0842
is: SBO:0000185
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
type: Reaction
fast: false
name: Postulated transport reaction
reversible: true
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9b558564_9df9_4555_92d9_7de6f4365f7d
is: E7EX19
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: PIK3R1
type: Species
is encoded by: hsa:5295
is: SBO:0000252

metaR DIDPtn
reactant: MODEL1310110034#
fast: false
type: Reaction
kinetic law: MODEL1310110034#
name: dIDP nuclear transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_870faf65_0221_49bf_94bd_1c96441d5c12
name: _R14373_1_x
initial concentration: NaN
is encoded by: hsa:R14373
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_412c567e_2052_43b3_b232_ebfb1f5a86cc
boundary condition: true
is encoded by: hsa:2591
constant: false
initial concentration: NaN
is: Q14435
has only substance units: false
type: Species
initial amount: NaN
name: GALNT3
is: SBO:0000252

metaR RE1796R
reactant: MODEL1310110034#
name: RE1796
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000000
product: MODEL1310110034#
reversible: true
type: Reaction

metaM HC01410 m
boundary condition: false
is: CHEBI:28706
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA

metaR DESAT18 3
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000269
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
type: Reaction
is: SBO:0000176
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

metaM gthox c
initial concentration: 1.0
is: C00127
initial amount: NaN
type: Species
name: Oxidized glutathione
is: HMDB03337
is: CHEBI:58297
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

metaR GLCAASE4ly
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110034#

metaM xoldiolone c
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
initial concentration: 1.0
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
is: CHEBI:28477
is: HMDB02197
boundary condition: false
has only substance units: false

metaR ADSL1
kinetic law: MODEL1310110034#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
name: adenylosuccinate lyase
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_30b7658d_330f_406a_9315_ace1dbd278a4
constant: false
name: AK2
is encoded by: hsa:204
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P54819
has only substance units: false
initial amount: NaN

metaR r0994
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#
name: Facilitated diffusion

metaM atp n
has only substance units: false
is: HMDB00538
boundary condition: false
initial concentration: 1.0
is: CHEBI:57299
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaM HC01223 m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
initial concentration: 1.0
is: CHEBI:57340
has only substance units: false
type: Species
initial amount: NaN
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
constant: false
is: SBO:0000247

metaM 3odcoa m
is: HMDB03939
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR PPItm
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
reversible: true
name: diphopshate transporter, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.

metaM mthgxl c
is: HMDB01167
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial concentration: 1.0
is: SBO:0000247
name: methylglyoxal
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:17158

metaR CRNrtx
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: reversible transport of L-Carnitine in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
fast: false
reactant: MODEL1310110034#

metaM leuktrF4 c
initial concentration: 1.0
is: HMDB06465
type: Species
boundary condition: false
name: leukotriene F4
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN

metaR HSAT3ly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a2938e5f_f9fb_433b_86eb_b5553076e17d
boundary condition: true
is encoded by: hsa:27034
name: ACAD8
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q6ZWP6
initial amount: NaN

metaM didp c
constant: false
name: dIDP
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB03536
is: CHEBI:28823

http://identifiers.org/biomodels.db/MODEL1310110034#_63ee0ba3_1a89_41ce_b8bb_913b2ad9194c
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _N63787_1_c
boundary condition: true
is encoded by: hsa:N63787

http://identifiers.org/biomodels.db/MODEL1310110034#_685186e7_8bb1_4ea0_9647_7e2cbf3ae0f1
is: SBO:0000252
is: Q96I99
constant: false
is encoded by: hsa:8801
boundary condition: true
has only substance units: false
name: SUCLG2
initial concentration: NaN
type: Species
initial amount: NaN

metaR PIPLCn
is: SBO:0000176
reversible: false
fast: false
name: phosphatidylinositol phospholipase C, nucleus
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

metaM orn m
boundary condition: false
name: Ornithine
constant: false
is: CHEBI:46912
is: HMDB00214
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_ec29ebc3_9752_43eb_a14d_cc4761c5dacb
is encoded by: hsa:788
constant: false
is: O43772
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC25A20
is: SBO:0000252
initial amount: NaN
type: Species

metaR r1527
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110034#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110034#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR KHte
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000185

metaM 4mzym int1 r
constant: false
boundary condition: false
is: HMDB06927
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 4-Methylzymosterol intermediate 1
type: Species
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial amount: NaN

metaM mthgxl e
constant: false
is: HMDB01167
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal
is: CHEBI:17158
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_d3f06253_0ba5_4af3_8ed2_9060c7543d97
name: SPTLC2
boundary condition: true
initial amount: NaN
is: O15270
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9517

metaR 4HGLSDm
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000212
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
fast: false
reversible: true

metaR PYRt2p
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
type: Reaction
is: SBO:0000185
name: pyruvate peroxisomal transport via proton symport
reversible: true
fast: false
product: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#

metaM HC02204 e
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
initial amount: NaN
name: prostaglandin-b1
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5432f42a_96dc_4bff_8ba9_0dcf844014fe
is: P14410
is: SBO:0000252
is encoded by: hsa:6476
initial concentration: NaN
name: SI
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR 5HOXINDACTO2OX
modifier: MODEL1310110034#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000304
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176

metaM lnlncgcoa r
is: HMDB06368
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
constant: false

metaM atp m
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57299
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00538
name: ATP(4-)
is: C00002

metaR SARDHm
kinetic law: MODEL1310110034#
name: Sarcosine dehydrogenase (m)
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.5.99.1
reversible: false
fast: false

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_776dfdd1_ef97_4712_8715_5c0ff74eb0ce
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:37
name: ACADVL
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P49748
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_050bc763_ea6c_4968_9f16_bd832589c963
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR RE1342C
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
name: RE1342
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_db3bb767_f1a8_47b3_a291_488dff728988
name: ST3GAL1
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6482
has only substance units: false

metaM retinal r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
has only substance units: false
is: HMDB01358
type: Species
name: retinal
initial amount: NaN
is: CHEBI:15035
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
boundary condition: false
is: CHEBI:17737
has only substance units: false
name: desmosterol
initial amount: NaN
is: HMDB02719
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a4245a6c_8578_403d_b3c1_471e6e009ee0
is encoded by: hsa:3421
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: P51553
initial amount: NaN
has only substance units: false
type: Species
name: IDH3G

http://identifiers.org/biomodels.db/MODEL1310110034#_3f0731d2_cb95_4a54_bbc5_b8198719f9ad
name: _AI990637_1_x
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AI990637
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM duri e
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
is: HMDB00012
is: C00526
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: Deoxyuridine
is: CHEBI:16450

metaR BALAPAT1tc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

metaR NACHEX14ly
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
is: SBO:0000176

metaM Lcyst c
initial amount: NaN
is: SBO:0000247
name: L-cysteate(1-)
is: HMDB02757
constant: false
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:58090

http://identifiers.org/biomodels.db/MODEL1310110034#_5cf13fc9_2e26_4f6a_8aba_86112f6cf0c7
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: PIK3C3
has only substance units: false
is encoded by: hsa:5289
boundary condition: true
initial amount: NaN
is: Q8NEB9

http://identifiers.org/biomodels.db/MODEL1310110034#_50eb1164_0079_4745_a6a2_170bb97a7d29
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:217
constant: false
name: ALDH2
has only substance units: false
initial amount: NaN
is: P05091

metaM ksi l
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01354
boundary condition: false
initial concentration: 1.0
is: C00445
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: keratan sulfate I
is: CHEBI:57455

metaR S6TASE13ly
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110034#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9218c66a_4878_4042_8845_76d726b43092
initial amount: NaN
is: SBO:0000252
type: Species
name: ACLY
boundary condition: true
initial concentration: NaN
constant: false
is: P53396
has only substance units: false
is encoded by: hsa:47

http://identifiers.org/biomodels.db/MODEL1310110034#_109166dc_7e5b_43aa_b95a_793853f568c7
initial amount: NaN
boundary condition: true
is: Q8TCG5
is: SBO:0000252
has only substance units: false
name: CPT1C
initial concentration: NaN
is encoded by: hsa:126129
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_7734c10e_5cf5_47d2_a901_3a82bb9f08c2
initial concentration: NaN
name: PIK3CA:PIK3R1
is encoded by: hsa:5295
has part: P27986
initial amount: NaN
boundary condition: true
is: SBO:0000297
type: Species
constant: false
has only substance units: false

metaM Ssq23epx r
constant: false
name: (S)-2,3-epoxysqualene
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15441
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: HMDB01188
type: Species

metaM lnlccoa c
type: Species
name: linoleic coenzyme A
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164

metaR DM atp c
name: DM_atp(c)
type: Reaction
kinetic law: MODEL1310110034#
fast: false
reversible: false
is described by: ECO:0000134
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110034#

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_a72e2f8d_ead0_469f_b107_d96fe98aba01
is: Q6IB80
boundary condition: true
has only substance units: false
name: NDUFB3
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4709
type: Species
is: SBO:0000252

metaR ALCD22 L
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (L-lactaldehyde)
is described by: ECO:0000304
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
reversible: false
reactant: MODEL1310110034#
is: SBO:0000176

metaR CYTK7n
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP),nuclear
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
fast: false

metaM duri c
is: SBO:0000247
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
initial amount: NaN
is: HMDB00012
initial concentration: 1.0
is: C00526
type: Species
constant: false
name: Deoxyuridine
has only substance units: false

metaR FATP2t
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
name: fatty acid electroneutral transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR S6TASE20ly
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_735ddf1d_a52e_44ae_be14_eb036c4f0acf
boundary condition: true
constant: false
is encoded by: hsa:9651
is: O75038
name: PLCH2
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaM sphmyln hs g
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
name: sphingomyelin betaine
boundary condition: false
has only substance units: false
is: CHEBI:58216
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM amp m
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
is: SBO:0000247
is: HMDB00045
constant: false
has only substance units: false
is: CHEBI:456215
boundary condition: false
name: AMP(2-)
initial amount: NaN

metaR ADSS
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
fast: false
is: SBO:0000176
modifier: MODEL1310110034#
reversible: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.3.4.4
name: adenylosuccinate synthase
type: Reaction
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_6d1fac5a_5d60_42d5_bced_88789fe14b3d
constant: false
is encoded by: hsa:10654
type: Species
name: PMVK
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q6FGV9

http://identifiers.org/biomodels.db/MODEL1310110034#_62deacfa_92c7_4954_88c1_dbc8ff1647ca
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: B3KVA3
is encoded by: hsa:112724
initial amount: NaN
boundary condition: true
name: RDH13
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_719fcba4_63f7_4ec1_a5cf_1c311e4a196d
initial amount: NaN
is encoded by: hsa:57665
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q9HBH5
boundary condition: true
constant: false
name: RDH14

metaR AMETtd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110034#
reversible: true
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_a44cdab4_7418_48db_81c9_92bb7a7742c4
initial amount: NaN
boundary condition: true
is: Q99643
has only substance units: false
is encoded by: hsa:6391
initial concentration: NaN
name: SDHC
constant: false
is: SBO:0000252
type: Species

metaR RE2069C
kinetic law: MODEL1310110034#
name: RE2069
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#

metaR HGNTOR
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.5
reactant: MODEL1310110034#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c0d4c360_30c3_4deb_a59c_0fe37616ff45
type: Species
constant: false
initial concentration: NaN
is: Q8WXF9
boundary condition: true
is encoded by: hsa:66035
name: SLC2A11
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b4a4cab5_35f8_4c99_a8a4_2b5611e217eb
initial concentration: NaN
name: PLCB1
constant: false
is: SBO:0000252
is encoded by: hsa:23236
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q9NQ66

http://identifiers.org/biomodels.db/MODEL1310110034#_afb82602_2cc8_4656_8a92_4f6ac39f595c
is encoded by: hsa:10558
name: SPTLC1:SPTLC2
type: Species
is: SBO:0000297
is encoded by: hsa:9517
constant: false
has part: O15270
has only substance units: false
boundary condition: true
initial amount: NaN
has part: O15269
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_4aab79d9_fd73_4f0a_84b2_6dbac20d03f2
name: DHCR7
initial amount: NaN
is: SBO:0000252
is: Q9UBM7
is encoded by: hsa:1717
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM msa m
boundary condition: false
constant: false
name: 3-oxopropanoate
type: Species
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial amount: NaN
is: HMDB11111
initial concentration: 1.0
has only substance units: false
is: CHEBI:33190

metaR IPDDIx
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.2
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
modifier: MODEL1310110034#
name: isopentenyl-diphosphate D-isomerase
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR DGULND
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
kinetic law: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_a2092e15_21fd_4bfc_9a4a_f5dfb7ae0ac7
type: Species
is encoded by: hsa:54995
constant: false
initial amount: NaN
name: OXSM
initial concentration: NaN
is: SBO:0000252
is: Q9NWU1
boundary condition: true
has only substance units: false

metaR NADtpu
fast: false
kinetic law: MODEL1310110034#
name: NAD transporter, peroxisome
is described by: ECO:0000000
reversible: false
product: MODEL1310110034#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110034#

metaR GALASE18ly
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110034#_afd19cc0_e6e2_4de9_858a_e2a67a1a6871
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: P06865
is encoded by: hsa:3073
initial amount: NaN
boundary condition: true
name: HEXA

metaM atp c
is: SBO:0000247
boundary condition: false
is: HMDB00538
is: C00002
is: CHEBI:30616
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: ATP(4-)

metaR BILGLCURtr
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
name: glucuronidated compound transport
fast: false
reversible: true

metaM dgmp e
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
name: dGMP(2-)
type: Species
boundary condition: false
is: CHEBI:57673
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM xylt c
initial concentration: 1.0
initial amount: NaN
is: HMDB02917
is: CHEBI:17151
type: Species
is: SBO:0000247
name: xylitol
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reversible: false
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000176

metaR TRIODTHYt2
reversible: true
name: T3 transport via facilitated diffusion
type: Reaction
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110034#

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
fast: false
is described by: ECO:0000269
name: phosphoribosylaminoimidazole carboxylase

http://identifiers.org/biomodels.db/MODEL1310110034#_63db65bf_1c04_4caf_bb7c_b5c3de9b21bb
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4830
name: NME1
is: SBO:0000252
boundary condition: true

metaM dcamp c
is: SBO:0000247
type: Species
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: CHEBI:57567
is: HMDB00536
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C03794

metaR A4GNT2g
reactant: MODEL1310110034#
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_0c659d54_0f95_4dbf_95a9_159a5177762a
name: GPX2
type: Species
initial amount: NaN
is encoded by: hsa:2877
constant: false
has only substance units: false
is: P18283
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_76a0f907_297f_48b3_a7a3_91b410888155
has only substance units: false
type: Species
name: HK1
is: Q59FD4
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3098
is: SBO:0000252
boundary condition: true

metaR r0413
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:

metaM idp c
is: CHEBI:58280
boundary condition: false
name: IDP(3-)
is: HMDB03335
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

http://identifiers.org/biomodels.db/MODEL1310110034#_e460d464_f5b2_4315_90f8_23ed322a7153
is encoded by: hsa:4830
boundary condition: true
initial amount: NaN
has part: P15531
initial concentration: NaN
has part: P22392
is encoded by: hsa:4831
has only substance units: false
is: SBO:0000297
name: NME1:NME2
type: Species
constant: false

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_c11b4405_bd7a_454f_9109_e8737613da1d
is: B2RAU6
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: PIGQ
is encoded by: hsa:9091

http://identifiers.org/biomodels.db/MODEL1310110034#_bbcae7b8_a679_41cc_af9e_0d683930bed7
has only substance units: false
is: O00330
boundary condition: true
is encoded by: hsa:8050
name: PDHX
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaM ocdcea r
is: C00712
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00207
boundary condition: false
initial amount: NaN

metaR S6TASE23ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#

metaR EX glgchlo LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-glycocholate complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_580ed058_1deb_4208_bc85_73ff611695a9
name: PANK1
boundary condition: true
constant: false
type: Species
is encoded by: hsa:53354
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM dgmp c
initial concentration: 1.0
constant: false
is: C00362
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01044
type: Species
has only substance units: false

metaR MI3PP
name: myo-inositol 3-phosphatase
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
product: MODEL1310110034#

metaM atp e
has only substance units: false
type: Species
name: ATP(4-)
constant: false
initial amount: NaN
is: C00002
is: SBO:0000247
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110034#_8609666b_ec59_4fb3_8e12_65043af97e1b
is encoded by: hsa:29124
boundary condition: true
has only substance units: false
name: LGALS13
is: SBO:0000252
is: Q9UHV8
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM CE2434 m
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:57795
initial concentration: 1.0

metaM gm2 hs g
constant: false
has only substance units: false
initial amount: NaN
name: N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-beta-D-glucosyl-(1<->1)-ceramide anion
is: CHEBI:58857
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C49H85N3O25FULLRCO CHARGE: -1
is: SBO:0000247

metaR 2MCITt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
is described by: ECO:0000000
is: SBO:0000185
name: 2-methylcitrate transport via diffusion
reversible: true
type: Reaction
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR EHGLAT2m
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaR HDDACBP
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2ccf9ffe_7516_4b89_8c18_10bd4b4051f2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:AGPAT7
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _AGPAT7_1_c

metaM HC01610 e
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: CoproporphyrinogenI
type: Species
is: CHEBI:28607
is: SBO:0000247
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768

metaR IDOURtly
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reversible: true
reactant: MODEL1310110034#
type: Reaction
name: iduronate transport into lysososme
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaM 34dhpac c
type: Species
is: CHEBI:27978
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: SBO:0000247
is: HMDB03791
boundary condition: false
name: 3,4-Dihydroxyphenylacetaldehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_bb008bdd_ba2d_40a5_a4b2_2cc9750fccfb
has only substance units: false
is: P09917
initial amount: NaN
name: ALOX5
boundary condition: true
is encoded by: hsa:240
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_fbb0c9d2_41be_4115_836c_eba449a2f2a1
has only substance units: false
is encoded by: hsa:9551
name: ATP5J2
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: P56134

http://identifiers.org/biomodels.db/MODEL1310110034#_1c4bf718_f210_4b2c_b293_67d8bcbaf6e8
name: HKDC1
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:80201
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: B3KT70

metaR DMATTx
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110034#
name: dimethylallyltranstransferase

metaR RE2625C
is: SBO:0000176
product: MODEL1310110034#
name: RE2625
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR DOPASFt
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
reversible: false
kinetic law: MODEL1310110034#
name: Dopamine 3-0-sulfate transport (diffusion)

metaM HC02205 c
initial amount: NaN
is: CHEBI:28099
boundary condition: false
constant: false
name: prostaglandin-b2
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaM orn c
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:0
type: Species
is: C01602
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Ornithine

metaR r2393
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110034#

metaR FE2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
product: MODEL1310110034#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110034#
name: iron (II) transport
fast: false
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000185

metaM amp e
initial amount: NaN
type: Species
constant: false
is: HMDB00045
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: AMP
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
is: C00020

metaM icit m
is: HMDB00193
name: Isocitrate
type: Species
is: C00311
initial amount: NaN
boundary condition: false
is: CHEBI:16087
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR CSNAT3x
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
fast: false
reversible: true
name: carnitine O-aceyltransferase, peroxisomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_59fb5b7c_f045_4d33_90ee_540c97fa5a93
is: SBO:0000252
is: Q6P1K9
boundary condition: true
name: PANK2
is encoded by: hsa:80025
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR GLCt4
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: glucose transport via sodium symport
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
product: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#

metaM hs deg1 l
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01352
initial amount: NaN
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: CHEBI:17180
name: heparan sulfate, degradation product 1
has only substance units: false
constant: false

metaR r0780
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_066bb3cb_a4f6_4333_bc17_a1380db40470
initial concentration: NaN
boundary condition: true
type: Species
name: SLC1A4
is encoded by: hsa:6509
is: P43007
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR DHCR72r
reversible: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
name: 7-dehydrocholesterol reductase
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.21
fast: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b3615e19_9244_4791_b984_685e9c07e804
is encoded by: hsa:50
initial concentration: NaN
is: Q99798
type: Species
constant: false
has only substance units: false
name: ACO2
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is version of: http://identifiers.org/ec-code/1.14.16.4
reversible: false
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is described by: ECO:0000269
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#

metaM betald m
is: HMDB01252
is: CHEBI:15710
has only substance units: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: betaine aldehyde
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_4e023d66_5b0a_4f7e_918e_b2746acd8c7b
boundary condition: true
is: SBO:0000252
type: Species
name: SLC27A2
is encoded by: hsa:11001
initial amount: NaN
is: O14975
has only substance units: false
initial concentration: NaN
constant: false

metaM thp2c x
boundary condition: false
is: HMDB12130
initial concentration: 1.0
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16987
has only substance units: false
name: 1-piperideine-6-carboxylate

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM HC02205 e
is: CHEBI:28099
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM man1p c
has only substance units: false
is: HMDB06330
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:35374
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial concentration: 1.0
constant: false

metaR LINOFATPtc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r0629
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.22
is: SBO:0000176
type: Reaction
reactant: MODEL1310110034#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_0cc87c94_00b8_49f3_9bfe_2faf90ef669a
is encoded by: hsa:84569
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: Q6UWQ5
boundary condition: true
initial amount: NaN
name: LYZL1

metaM ipdp x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01347
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: SBO:0000247
is: CHEBI:128769
type: Species
boundary condition: false
constant: false
name: isopentenyl diphosphate(3-)

metaM amp c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
constant: false
initial concentration: 1.0
is: HMDB00045
is: CHEBI:3322
name: AMP
boundary condition: false
is: SBO:0000247
is: C00020

http://identifiers.org/biomodels.db/MODEL1310110034#_a3462e21_5b72_49dc_91e0_3f9027061585
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q16718
name: NDUFA5
is encoded by: hsa:4698
type: Species

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02917
is: CHEBI:17151
has only substance units: false
is: SBO:0000247
constant: false
name: xylitol

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f9e03c37_c4dd_491c_964c_b8db38dc7e2f
is: P19404
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4729
initial concentration: NaN
name: NDUFV2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_bcefa697_e3a3_459b_9353_beb3cedbf794
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ADCY5
constant: false
is encoded by: hsa:111
is: SBO:0000252
is: O95622
type: Species
has only substance units: false

metaR C5DCe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c908dbf1_7568_4285_b699_384c77ae8f5c
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:30
is: Q96CA6
name: ACAA1

http://identifiers.org/biomodels.db/MODEL1310110034#_1f4bd515_1c2a_4b4b_b465_b43286bcb6a2
type: Species
initial concentration: NaN
is encoded by: hsa:3030
boundary condition: true
constant: false
initial amount: NaN
name: HADHA
has only substance units: false
is: E9KL44
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_09cb88d7_cc65_4792_9110_137193ee6c0e
is encoded by: hsa:126
has only substance units: false
name: ADH1C
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: P00326
boundary condition: true
constant: false

metaM pail3p hs c
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: CHEBI:58088
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR SPMTDe
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: SPMTDe
reactant: MODEL1310110034#
is described by: ECO:0000134
fast: false
reversible: true

metaM c10crn c
notes: FORMULA: C17H33NO4 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00651
initial amount: NaN
boundary condition: false
constant: false
name: decanoyl carnitine
has only substance units: false

metaR CSPG Etly
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: chondroitin sulfate E transport, extracellular to lysosome
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaM dem2emgacpail prot hs r
initial concentration: 1.0
boundary condition: false
is: HMDB01311
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: CHEBI:16004
type: Species
constant: false
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM odecoa c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB01322
has only substance units: false
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
is: CHEBI:3793
initial amount: NaN

metaM adpac x
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00448
notes: FORMULA: C6H8O4 CHARGE: -2
is: SBO:0000247
name: adipic acid
boundary condition: false
constant: false
has only substance units: false

metaR PALFATPtc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_40066277_f742_4409_86fa_6fd4346919e0
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI684467_1_m
is encoded by: hsa:AI684467

http://identifiers.org/biomodels.db/MODEL1310110034#_73c15646_e1e5_4a68_b34f_6355abd3937d
initial amount: NaN
constant: false
is: Q4FEB3
initial concentration: NaN
is encoded by: hsa:1215
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CMA1
type: Species

metaR ORNt3m
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110034#
product: MODEL1310110034#
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true

metaR r2390
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#

metaM ala L e
has only substance units: false
initial concentration: 1.0
constant: false
name: L-alanine
is: CHEBI:16977
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR ADSK
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: adenylyl-sulfate kinase
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#

metaM na1 c
type: Species
initial amount: NaN
is: SBO:0000247
name: Sodium
is: HMDB00588
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: C01330
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:4541

metaR GLUt2m
reversible: true
name: L-glutamate reversible transport via proton symport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_3d4baf3e_3c78_4640_a36c_2aa4c31c7051
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4731
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4712
has part: Q5VYT2

metaR r1944
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR DAGK hs
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110034#

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
is: HMDB06894
is: CHEBI:27428
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM c10crn e
is: HMDB00651
constant: false
notes: FORMULA: C17H33NO4 CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: decanoyl carnitine
has only substance units: false

metaR LALDO
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is: SBO:0000176
modifier: MODEL1310110034#
reversible: true
is described by: ECO:0000000
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_fb35e3f8_6e8a_4816_835e_934a33b3f39b
is: B2R6S5
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:51727
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: CMPK1

http://identifiers.org/biomodels.db/MODEL1310110034#_98cefd30_dead_4817_b31f_0b692bc0af27
constant: false
is encoded by: hsa:8611
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: G3XA95
name: PPAP2A
type: Species
initial amount: NaN
has only substance units: false

metaM hs deg7 l
name: heparan sulfate, degradation product 7
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01352
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: CHEBI:17180

http://identifiers.org/biomodels.db/MODEL1310110034#_18dabd32_1c8e_4d2e_bf8c_2000c1e80dd8
name: _AW299740_1_m
is encoded by: hsa:AW299740
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e52e630b_cf2d_42d8_9087_6bffe5e714ea
constant: false
name: PIGF
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5281
is: Q6IB04
type: Species

metaM tetdece1crn e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02014
boundary condition: false
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
initial concentration: 1.0
initial amount: NaN

metaR r1943
type: Reaction
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9171f945_30f9_48e4_8298_3094e64689e1
is encoded by: hsa:29922
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: NME7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_5e7828e0_92ae_49e6_9f10_b42ae10d5e6a
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2222
name: FDFT1
is: P37268
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_472b9e1c_3804_49d1_b7e9_a6aa94011497
is encoded by: hsa:AI620219
name: _AI620219_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_64cffd39_dab2_4626_a9fa_09c61e97bf34
initial concentration: NaN
constant: false
is: Q9BWD1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: ACAT2
is encoded by: hsa:39

metaM na1 e
is: C01330
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Sodium
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_7944165b_fb6c_428c_8d6f_37f78dee88b2
constant: false
initial amount: NaN
type: Species
is: P13073
is: SBO:0000252
name: COX4I1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1327
has only substance units: false

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
boundary condition: false
type: Species
is: HMDB01070
is: C01944
is: CHEBI:57386
constant: false
initial concentration: 1.0
initial amount: NaN

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58216
initial amount: NaN
type: Species
initial concentration: 1.0

metaR FERO
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000176
fast: false
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
name: ferroxidase

metaR PNP
fast: false
type: Reaction
name: purine-nucleoside phosphorylase
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
reversible: true
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#

metaM ala L c
is: SBO:0000247
initial amount: NaN
is: CHEBI:16977
constant: false
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
type: Species
boundary condition: false
name: L-alanine
initial concentration: 1.0

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR TXASr
reactant: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.3.99.5
name: Thromboxane-A synthase
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110034#

metaR r2087
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR URAt
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
type: Reaction
name: uracil transport via facilated diffusion
reversible: true

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r2389
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
modifier: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000

metaR SEBCOAPET
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM 2dr1p c
boundary condition: false
name: 2-Deoxy-D-ribose 1-phosphate
is: SBO:0000247
initial amount: NaN
is: CHEBI:58576
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: C00672
has only substance units: false
is: HMDB01351

metaM ksii core2 deg3 l
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 3
is: CHEBI:12936
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C58H94N5O46S2X CHARGE: -2

metaR r2086
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110034#

metaR DNDPt8m
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
product: MODEL1310110034#
name: dADP transport via dUDP antiport

metaR r0634
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110034#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
type: Reaction

metaM acgam e
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: HMDB00215
is: CHEBI:17411

metaR r0787
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reversible: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is: SBO:0000176
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_0c4b690d_f2ce_4e68_988a_8ed9cce75c49
is encoded by: hsa:AI935189
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _AI935189_1_m

http://identifiers.org/biomodels.db/MODEL1310110034#_22133ec7_4a7e_4216_bf73_85c30e7c060d
initial concentration: NaN
has only substance units: false
type: Species
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
boundary condition: true
initial amount: NaN
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_adce3365_ccc3_4e17_b57d_976969e95714
is encoded by: hsa:AA664770
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AA664770_1_m
type: Species

metaR C10DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR r0013
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
kinetic law: MODEL1310110034#

metaR r0560
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: false

metaR r0633
product: MODEL1310110034#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000

metaR NICRNS
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
name: NICRNS
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_4f818226_75a7_4294_9e2a_52fa86c4040d
boundary condition: true
has only substance units: false
name: SLC5A11
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:115584
is: Q8WWX8

metaM na1 r
is: CHEBI:29101
name: sodium(1+)
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

metaR HIBDm
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is version of: http://identifiers.org/ec-code/1.1.1.31
is described by: ECO:0000269
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
type: Reaction
reversible: true
fast: false
product: MODEL1310110034#

metaR r2089
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_3cdb0e4d_b023_437e_bdd3_f0301d5e460f
has only substance units: false
type: Species
constant: false
is encoded by: hsa:11332
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACOT7
initial concentration: NaN
is: O00154

metaM succoa m
constant: false
has only substance units: false
is: SBO:0000247
name: Succinyl-CoA
boundary condition: false
is: CHEBI:57292
initial amount: NaN
is: HMDB01022
initial concentration: 1.0
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

http://identifiers.org/biomodels.db/MODEL1310110034#_779c0ae7_63e7_445a_bfa2_2d6d826c7cb2
type: Species
is: SBO:0000252
name: LGSN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q5TDP6
is encoded by: hsa:51557
initial amount: NaN

metaR NDP7ex
is described by: ECO:0000269
product: MODEL1310110034#
type: Reaction
fast: false
name: nucleoside-diphosphatase (UDP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaM 2maacoa m
constant: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
is: HMDB01157
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57335
name: 2-methylacetoacetyl-CoA(4-)
is: SBO:0000247

metaR APAT2rm
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000212
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2410934f_e66c_46f6_b22d_4506e79afbf5
name: _LOC647190_1_c
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:LOC647190
is: SBO:0000252

metaM acgam c
is: CHEBI:17411
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
name: N-acetyl-D-glucosamine
is: HMDB00215

metaR UPPDC1
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.37
type: Reaction
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR r2088
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_f471608f_e7e4_4059_90cc_bb49091c8052
is: P24310
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1346
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: COX7A1

metaR ARTCOAL2
is: SBO:0000176
name: R group coenzyme a ligase
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b82def46_5d01_4f1d_b007_75893f2c8e3d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:C7orf24
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: _C7orf24_1_m

metaR r0784
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
modifier: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_2f962d0d_1ebc_47ff_82d6_6784a086274a
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B3KTV4
is encoded by: hsa:122622
name: ADSSL1

metaR NDPK3n
fast: false
reversible: true
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR NACHEX27ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000269
kinetic law: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
modifier: MODEL1310110034#
is: SBO:0000176

metaR r2386
reactant: MODEL1310110034#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#
is: SBO:0000185

metaM no e
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB03378
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16480
is: SBO:0000247
name: Nitric oxide

metaR LPCOXp
kinetic law: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
type: Reaction
reversible: false
name: L-pipecolate oxidase, peroxisomal
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1
fast: false

metaR COt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110034#
name: CO transporter via diffusion
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000185

metaM Nacasp m
type: Species
is: SBO:0000247
name: N-acetyl-L-aspartate(2-)
is: HMDB00812
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
boundary condition: false
has only substance units: false

metaM pro D e
is: CHEBI:16313
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: D-proline

metaM ddeccrn c
initial amount: NaN
name: lauroyl carnitine
is: HMDB02250
notes: FORMULA: C19H37NO4 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR MECOAS1m
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110034#
name: mesaconate--CoA ligase (GDP-forming)
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000304

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
is: HMDB06894
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
initial concentration: 1.0

metaM ksi deg23 l
type: Species
initial concentration: 1.0
constant: false
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 23
is: CHEBI:12936
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_dabdaaf5_df1b_4e35_a910_2643c51d2a0b
initial concentration: NaN
initial amount: NaN
constant: false
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r2385
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
modifier: MODEL1310110034#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_98e68c01_1061_4627_b0fa_c4db3c2f200f
type: Species
initial concentration: NaN
is encoded by: hsa:9245
initial amount: NaN
constant: false
name: GCNT3
is: O95395
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM orot c
is: HMDB00226
initial concentration: 1.0
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
constant: false
is: C00295
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:30839
is: SBO:0000247

metaR r0638
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.8.1.2

http://identifiers.org/biomodels.db/MODEL1310110034#_0117eb78_31f8_40cb_b9ae_f6234ef780b4
is: O14495
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8613
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: PPAP2B

metaM aacoa c
initial amount: NaN
is: HMDB01484
is: C00332
is: CHEBI:57286
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
name: Acetoacetyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110034#_b7bfa89b_a35f_480c_b1d3_6ef2a710c920
is encoded by: hsa:3939
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: LDHA
is: P00338
has only substance units: false

metaR MALTSULtm
is: SBO:0000185
fast: false
name: Malate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2e0fce19_e8c2_4814_80eb_97bbf2248310
is encoded by: hsa:6514
name: SLC2A2
is: P11168
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM pro L c
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:17203
is: HMDB00162
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
boundary condition: false
initial amount: NaN

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110034#

metaM ddeccrn e
type: Species
name: lauroyl carnitine
notes: FORMULA: C19H37NO4 CHARGE: 0
has only substance units: false
boundary condition: false
is: HMDB02250
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR CYTDK2m
fast: false
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: cytidine kinase (ATP), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM gp1calpha hs c
constant: false
boundary condition: false
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
name: GP1c alpha
is: CHEBI:3513
initial concentration: 1.0
initial amount: NaN
is: C00213
is: SBO:0000247
is: HMDB00271
has only substance units: false
type: Species

metaM mescoa m
is: SBO:0000247
boundary condition: false
is: CHEBI:27969
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
type: Species
name: Mesaconyl-CoA
has only substance units: false
initial concentration: 1.0
constant: false
is: C06028

metaR r2387
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#

metaM acmana c
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: N-acetyl-D-mannosamine
is: HMDB01129
is: CHEBI:17122
initial concentration: 1.0
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false

metaM orot e
is: HMDB00226
initial amount: NaN
initial concentration: 1.0
name: orotate
constant: false
is: CHEBI:30839
is: SBO:0000247
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
has only substance units: false

metaM occoa m
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01070
boundary condition: false
initial concentration: 1.0
is: C01944
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
has only substance units: false
constant: false
name: L-alanine
initial concentration: 1.0
is: SBO:0000247
is: HMDB00161
is: CHEBI:16977
initial amount: NaN
type: Species

metaM hs deg13 l
type: Species
name: heparan sulfate, degradation product 13
is: CHEBI:17180
initial concentration: 1.0
is: HMDB01352
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6

metaM retinol cis 11 e
initial concentration: 1.0
is: HMDB06216
has only substance units: false
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
initial amount: NaN
type: Species
name: 11-cis-retinol
constant: false
is: CHEBI:16302

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM ksii core4 l
has only substance units: false
is: CHEBI:57614
boundary condition: false
is: HMDB00189
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
constant: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
type: Species
initial concentration: 1.0

metaR VALt5m
is described by: ECO:0000000
name: Valine reversible mitochondrial transport
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
product: MODEL1310110034#
type: Reaction

metaR DNDPt60m
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110034#
name: dGTP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110034#_164408cf_59d1_4ea5_a6b4_7cba16884fa6
constant: false
type: Species
name: _100287639_1_c
boundary condition: true
is encoded by: hsa:100287639
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM succoa c
initial concentration: 1.0
is: HMDB01022
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaM mescon m
is: HMDB00749
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: Mesaconate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: CHEBI:36986
has only substance units: false

metaR C3STDH1r
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reactant: MODEL1310110034#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176

metaM adpac c
initial concentration: 1.0
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
is: HMDB00448
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: adipic acid
has only substance units: false

metaR TDP
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: false
name: thiamin pyrophosphatase
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:2171493,PMID:8522961 NOTES:_01-25-05 IT AMF

http://identifiers.org/biomodels.db/MODEL1310110034#_1c0ce636_ca13_4eb6_9d73_bfef976ad5fc
initial amount: NaN
type: Species
is encoded by: hsa:2592
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: E7ET32
is: SBO:0000252
name: GALT

metaM c4crn c
type: Species
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02013
is: SBO:0000247
initial amount: NaN
constant: false
is: C02862

http://identifiers.org/biomodels.db/MODEL1310110034#_c6b859f5_ff21_4355_afb4_55ee7fcb82fb
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:10870
type: Species
is: Q9UBK5
name: HCST
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR EX tetdec2crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaR G3PD1
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#

metaM pro L e
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-proline
constant: false
is: HMDB00162
type: Species

metaM thmpp c
is: HMDB01372
is: C00068
is: SBO:0000247
name: Thiamine diphosphate
has only substance units: false
is: CHEBI:45931
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
product: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110034#_a8353e65_c950_404b_b4d2_ad97ba5f9ea9
is: Q99808
initial concentration: NaN
is encoded by: hsa:2030
name: SLC29A1
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM arab L c
initial amount: NaN
is: HMDB00646
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
is: CHEBI:30849
boundary condition: false
name: L-arabinose
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_39b7704c_6cf4_42d9_8a73_0d2559eb0723
is: SBO:0000252
type: Species
is: P23434
name: GCSH
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2653
boundary condition: true
initial amount: NaN
constant: false

metaR PLA2 2
is: SBO:0000176
name: phospholipase A2
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
fast: false

metaM retinol cis 11 c
boundary condition: false
constant: false
is: CHEBI:16302
name: 11-cis-retinol
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
has only substance units: false
is: HMDB06216
initial concentration: 1.0
type: Species

metaM sl L e
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
is: CHEBI:61289
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: (S)-3-sulfonatolactate(2-)

metaR ARSA
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
name: Arylsulfatase A
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.8
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
fast: false

metaR H2Otp
name: H2O transport, peroxisomal
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110034#

metaR TSTSTERONEtr
product: MODEL1310110034#
name: testosterone intracellular transport
reactant: MODEL1310110034#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_bd0132e8_95dd_4109_a29e_ee3e1222bd76
type: Species
constant: false
is: Q13057
initial amount: NaN
name: COASY
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80347
has only substance units: false

metaM gp1calpha hs e
has only substance units: false
name: GP1c alpha
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01397
is: CHEBI:58115
initial amount: NaN
boundary condition: false
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5

metaM ksi deg10 l
is: HMDB00812
is: CHEBI:16953
constant: false
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 10
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_399ea19d_d767_4c68_a9aa_77aeaeb759aa
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: MCCC2
is: Q9HCC0
type: Species
has only substance units: false
is encoded by: hsa:64087
initial concentration: NaN

metaM hista e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
constant: false
has only substance units: false
name: histamium
type: Species
is: HMDB00870
is: CHEBI:58432
initial amount: NaN

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR UDPG4E
name: UDPglucose 4-epimerase
is: SBO:0000176
fast: false
reactant: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
modifier: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110034#_1233c572_5e23_45af_8b5f_1fe4c31362a2
is: SBO:0000252
constant: false
name: PGS1
has only substance units: false
initial amount: NaN
is: Q32NB8
boundary condition: true
is encoded by: hsa:9489
initial concentration: NaN
type: Species

metaR r2081
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110034#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#

metaR r2497
kinetic law: MODEL1310110034#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
reactant: MODEL1310110034#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_fe7429a4_6275_4d5d_b94e_465e6ad6c631
initial amount: NaN
type: Species
is: Q8N0X4
has only substance units: false
constant: false
name: CLYBL
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:171425
boundary condition: true

metaR S6TASE7ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110034#
reversible: true
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110034#_ceb0a328_8d43_48ac_844c_f1f998e9ff42
boundary condition: true
is: P17812
initial amount: NaN
constant: false
name: CTPS1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1503

metaR r1400
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000185
fast: false
name: Active transport
reversible: false
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_38ac511d_0459_4f42_bbed_35d807e47b19
has only substance units: false
boundary condition: true
constant: false
name: PCBD1
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:5092
initial concentration: NaN

metaM sTn antigen g
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H30N2O13X CHARGE: -1
constant: false
is: HMDB00224
initial concentration: 1.0
name: sialyl-Tn antigen
type: Species
initial amount: NaN
is: CHEBI:58190

metaR r1401
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.51
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Facilitated diffusion
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.7.10.1

metaR NDPK3m
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

http://identifiers.org/biomodels.db/MODEL1310110034#_1773bb57_b88d_459d_8505_08a74197ee20
name: BCKDHB
has only substance units: false
type: Species
is: SBO:0000252
is: P21953
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:594
constant: false

metaM guln r
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
is: HMDB03290
is: CHEBI:13115
boundary condition: false
initial amount: NaN
name: L-gulonate

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r2080
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#

metaR H2Otn
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#
name: H2O transport, nuclear
fast: false
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM gp1calpha hs g
name: GP1c alpha
is: C00213
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
has only substance units: false
is: HMDB00271
initial concentration: 1.0
constant: false
is: CHEBI:3513

metaM ksi deg7 l
is: HMDB00812
name: keratan sulfate I, degradation product 7
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:16953
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: SBO:0000247
constant: false
boundary condition: false

metaM sl L c
is: SBO:0000247
boundary condition: false
constant: false
name: (S)-3-sulfonatolactate(2-)
is: CHEBI:61289
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_75b96a3f_22d1_4feb_881b_168e980860d1
is: SBO:0000252
initial concentration: NaN
is: P31937
initial amount: NaN
is encoded by: hsa:11112
constant: false
boundary condition: true
type: Species
has only substance units: false
name: HIBADH

http://identifiers.org/biomodels.db/MODEL1310110034#_6ea6f6d2_1901_4eae_8c60_2e02bd958d9e
name: DEGS1
constant: false
is encoded by: hsa:8560
is: O15121
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_382e0d5f_893c_4da5_ab42_ae9bbefe8752
name: SLC25A18
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:83733
initial amount: NaN
is: Q9H1K4
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_3677b947_db7b_4d6f_83d6_92fbb310c978
constant: false
has only substance units: false
initial concentration: NaN
name: GALNT14
is encoded by: hsa:79623
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q96FL9

metaM hista c
is: CHEBI:58432
type: Species
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00870
initial concentration: 1.0
boundary condition: false

metaM thp2c c
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16987
has only substance units: false
name: 1-piperideine-6-carboxylate
is: HMDB12130

metaR r2083
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR ALOX52
is version of: http://identifiers.org/ec-code/1.13.11.34
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
kinetic law: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
name: Arachidonate 5-lipoxygenase
fast: false

metaR SUCOAS1m
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110034#
modifier: MODEL1310110034#
name: Succinate--CoA ligase (GDP-forming)

metaR RE2349C
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is: SBO:0000176
name: RE2349
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_c307bced_6eb5_4ea1_9adb_43da60c83cc6
is: Q02221
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: COX6A2
is encoded by: hsa:1339
boundary condition: true
type: Species
is: SBO:0000252

metaM apoC Lys btn c
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
type: Species
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
is: CHEBI:32551
is: HMDB00182
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN

metaR PSt3
reversible: true
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_9a7fb2f7_3947_4802_af68_dd424ffeb216
is encoded by: hsa:1340
has part: P15954
has part: P24310
boundary condition: true
is encoded by: hsa:9377
is encoded by: hsa:4512
is encoded by: hsa:4514
initial concentration: NaN
has part: P00414
has part: H0UI06
is encoded by: hsa:1349
is encoded by: hsa:1327
is encoded by: hsa:1339
is encoded by: hsa:1350
has part: P14854
has part: Q7GXZ8
constant: false
has part: Q7GXY8
has part: Q6YFQ2
is encoded by: hsa:1345
is encoded by: hsa:341947
is encoded by: hsa:1337
is: SBO:0000297
is encoded by: hsa:9167
initial amount: NaN
type: Species
is encoded by: hsa:170712
is encoded by: hsa:125965
is encoded by: hsa:1329
has only substance units: false
is encoded by: hsa:1351
has part: Q53XN1
is encoded by: hsa:1346
has part: Q7Z4L0
has part: Q8TF08
is encoded by: hsa:84701
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P20674
has part: Q6FGA0
is encoded by: hsa:1347
has part: Q96KJ9
has part: P24311
has part: Q02221
has part: Q53YB7
is encoded by: hsa:4513
has part: P13073
has part: P12074
has part: P09669

metaR H2Otm
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
name: H2O transport, mitochondrial
modifier: MODEL1310110034#

metaM betald c
type: Species
is: CHEBI:15710
constant: false
has only substance units: false
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
name: betaine aldehyde
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r2082
is: SBO:0000185
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110034#

metaR r2202
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000000

metaM hs deg24 l
has only substance units: false
initial concentration: 1.0
name: GlcNAc-GlcA-(Gal)2-Xyl
notes: FORMULA: C31H50NO26 CHARGE: -1
type: Species
boundary condition: false
is: CHEBI:16126
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_7f069202_093a_4728_bca4_2e77551f59a5
is: O00142
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: TK2
is encoded by: hsa:7084
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r0630
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176

metaR FATP3t
fast: false
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
name: fatty acid electroneutral transport
is: SBO:0000185
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110034#_949995ad_0151_47ee_a1cc_4205541cd5dd
initial amount: NaN
constant: false
name: CHAT
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
is: D3DX95
initial concentration: NaN

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_8ff61a61_8500_43ef_b48b_a6370942d052
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: AK5
initial concentration: NaN
is encoded by: hsa:26289
has only substance units: false
is: SBO:0000252

metaR r2085
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#

metaR r0853
reversible: false
reactant: MODEL1310110034#
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
modifier: MODEL1310110034#
type: Reaction
name: D-fructose transport via sodium cotransport
reversible: true

metaM c4crn e
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02013
is: C02862
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
notes: FORMULA: C11H21NO4 CHARGE: 0

metaR r2201
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_c89c0243_eadd_4d77_b0a3_48679080dfbb
is: SBO:0000252
is: Q8N3E9
name: PLCD3
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:113026
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_a5e0d5d1_07fc_433d_8f04_daa363fc4f57
name: FLAD1
is: Q8NFF5
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:80308
has only substance units: false

metaM ksii core4 e
is: HMDB00211
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_bdf03fdc_f936_409b_aa7d_321969afbba3
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q5JRA6
boundary condition: true
name: MIA3
is encoded by: hsa:375056

metaM icit c
has only substance units: false
constant: false
name: Isocitrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
is: CHEBI:16087
is: SBO:0000247
is: HMDB00193
boundary condition: false
initial concentration: 1.0
is: C00311
type: Species

metaM air c
type: Species
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58592
is: HMDB01235
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C03373

metaR CTPtn
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
name: CTP diffusion in nucleus
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_528f0e3c_1a6b_4bed_98ef_788fbb24ca02
type: Species
constant: false
is encoded by: hsa:9194
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q8NEM3
name: SLC16A7
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_4ffa7142_b0d5_4b90_9bda_e080f0247fe7
constant: false
name: PLA2G2A
is encoded by: hsa:5320
initial concentration: NaN
is: P14555
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR r2084
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110034#_4bf631aa_3c1e_45f5_b47c_91691f615d1f
is: Q9NPB1
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: NT5M
is encoded by: hsa:56953
boundary condition: true
has only substance units: false

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431

http://identifiers.org/biomodels.db/MODEL1310110034#_6cd361f3_34df_46cf_b604_ddbffec3d2ee
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:27124
name: INPP5J
type: Species

metaM HC02207 e
boundary condition: false
name: prostaglandin-c2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:27555
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0494ccca_7b39_4a34_b3a4_9e45c2fef7be
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AI656480_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI656480

metaM arab L e
has only substance units: false
is: HMDB00646
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
type: Species
is: CHEBI:30849
constant: false
initial amount: NaN
name: L-arabinose
boundary condition: false

metaR r2200
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#

metaR RE1520M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176

metaR r0789
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110034#
product: MODEL1310110034#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR RPE
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR GLCNACASE3ly
is: SBO:0000176
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_2f962d6e_53e7_49a2_8b87_7bb837d69d75
is encoded by: hsa:518
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_686f5f0e_2afb_42ef_b3a2_025c979fe0e9
is: Q96NR8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:145226
is: SBO:0000252
name: RDH12
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR DHCR243r
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: 24-dehydrocholesterol reductase [Precursor]
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
product: MODEL1310110034#
is described by: ECO:0000134
fast: false

metaM HC02203 c
is: SBO:0000247
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: prostaglandin-a2

metaR r1598
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110034#
is described by: ECO:0000000
type: Reaction

metaR CHAT
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
kinetic law: MODEL1310110034#
type: Reaction
name: Choline O-acetyltransferase
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#

metaR r0464
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#

metaR r2125
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110034#

metaR ADNt
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
name: adenosine facilated transport in cytosol
fast: false

metaR r0721
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r2535
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110034#
fast: false
reversible: true

metaR UROLACer
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: uronolactonase, endoplasmic reticulum
type: Reaction

metaR 4HPRO LTte
fast: false
product: MODEL1310110034#
name: Transport of trans-4-hydroxy-L-proline
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR r2310
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110034#

metaR GLXtm
reactant: MODEL1310110034#
reversible: true
type: Reaction
fast: false
name: glyoxylate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#

metaR r1597
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110034#
reversible: true
fast: false

metaM dcholcoa r
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
has only substance units: false
constant: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB06292

metaR r2126
modifier: MODEL1310110034#
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reversible: true

metaR r0722
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction

metaR H2O2t
product: MODEL1310110034#
fast: false
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_96d10ead_fd15_4ea1_8fd8_aab771e94539
type: Species
name: NME3
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4832
is: Q13232
boundary condition: true
initial concentration: NaN

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_3d288486_5f4c_447d_87f4_912fe5e97374
name: ABAT
is encoded by: hsa:18
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P80404
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_6dfcd1ab_a945_4f2c_a810_5c25a63e9aae
is encoded by: hsa:AU149534
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AU149534_1_e
has only substance units: false

metaR r1596
type: Reaction
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_08d5fea1_8b00_4f00_bdc8_01a9d666a710
boundary condition: true
type: Species
is: P22304
initial concentration: NaN
name: IDS
is encoded by: hsa:3423
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ffe8b85e_4e0a_439f_bd1b_f1c3474bb471
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: HPGDS
is: O60760
is encoded by: hsa:27306
constant: false

metaR r0723
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR r2123
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_612dcb24_7ffc_4f03_b725_43ba0ca54224
boundary condition: true
type: Species
constant: false
is: P42126
initial amount: NaN
initial concentration: NaN
name: ECI1
is encoded by: hsa:1632
has only substance units: false
is: SBO:0000252

metaR PPDOx
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
type: Reaction

metaM maltttr e
initial amount: NaN
initial concentration: 1.0
name: Maltotetraose
type: Species
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: C02052
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296

metaR r2537
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110034#
name: Utilized transport
fast: false
kinetic law: MODEL1310110034#
type: Reaction
reversible: true

metaM lys L m
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
name: L-lysinium(1+)
initial amount: NaN
is: SBO:0000247

metaR r2312
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
fast: false

metaR r1595
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#

metaR r0463
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c69ae6d9_055b_4579_937b_badb37728f17
is encoded by: hsa:5279
boundary condition: true
is: Q92535
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PIGC
initial amount: NaN
constant: false
type: Species

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR PPDOy
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
product: MODEL1310110034#

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR r2124
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
reversible: true

metaM triodthy c
constant: false
is: HMDB00265
boundary condition: false
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
initial amount: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_626da98e_b18b_4897_a67c_1ea076b232a3
is: P51828
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: ADCY7
constant: false
initial concentration: NaN
is encoded by: hsa:113

metaR AATAi
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110034#
type: Reaction
reversible: false
name: 2-aminoadipate transaminase, irreversible

metaR r2313
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110034#
reversible: true
is: SBO:0000185
fast: false

metaM ump g
is: HMDB00288
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f2e09305_adae_4d80_959d_01a783a2c1d0
name: HSD17B10
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3028
is: Q99714
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c13e84d1_e169_41ac_9df9_69f11fad1bbb
is: SBO:0000252
constant: false
is encoded by: hsa:170712
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q8TF08
initial concentration: NaN
name: COX7B2
type: Species

metaM q10h2 m
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR RE1254C
is described by: ECO:0000000
name: RE1254
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_43d4a121_fb0c_4984_bdcd_0215fe00998d
is: SBO:0000252
name: TMEM91
has only substance units: false
initial concentration: NaN
is: C9JZ62
is encoded by: hsa:641649
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_dbd5f303_726c_41a6_8c37_c989d577bae3
constant: false
is: P21217
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2525
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: FUT3

metaR r2121
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110034#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_473c83cf_fb7f_4886_be5f_764e2bf0a506
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:411
initial amount: NaN
is: SBO:0000252
is: A8K4A0
type: Species
name: ARSB

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
fast: false
modifier: MODEL1310110034#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.9

http://identifiers.org/biomodels.db/MODEL1310110034#_205d4459_e147_401f_bb01_74611dee1f66
initial amount: NaN
type: Species
is encoded by: hsa:5313
is: P30613
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PKLR
initial concentration: NaN
constant: false

metaM cspg d l
is: HMDB06202
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H64N2O51S5X CHARGE: -7
initial concentration: 1.0
type: Species

metaR RE1533M
modifier: MODEL1310110034#
is: SBO:0000176
type: Reaction
name: RE1533
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true

metaM aicar c
type: Species
initial concentration: 1.0
is: C04677
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: HMDB01517

metaR r2314
reactant: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110034#

metaR FUMAC
fast: false
modifier: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110034#
reversible: false
name: fumarylacetoacetase
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.7.1.2

metaM octa c
is: HMDB00482
type: Species
initial concentration: 1.0
name: octanoate (n-C8:0)
is: CHEBI:25646
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
has only substance units: false
constant: false
initial amount: NaN
is: C06423
boundary condition: false

metaM 3hpcoa m
is: CHEBI:58528
initial concentration: 1.0
name: 3-hydroxypropanoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
is: HMDB06807

metaR SIAT9g
product: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reactant: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.9
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
kinetic law: MODEL1310110034#
type: Reaction
fast: false

metaR r2122
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#

metaR H2Otly
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
reversible: true
kinetic law: MODEL1310110034#

metaM HC02203 e
type: Species
is: SBO:0000247
name: prostaglandin-a2
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
boundary condition: false
initial concentration: 1.0
is: CHEBI:27820

http://identifiers.org/biomodels.db/MODEL1310110034#_b13630eb_12e5_4d57_a145_9eedb6a6b31e
constant: false
is encoded by: hsa:55568
initial concentration: NaN
is: SBO:0000252
name: GALNT10
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ump e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00288
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57865

metaR r2315
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#

metaR C4DCCACT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR LEUKTRD4t
type: Reaction
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: leukotriene D4 transport

metaR C12OHc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.92
is described by: ECO:0000134
kinetic law: MODEL1310110034#
fast: false
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial amount: NaN
name: 3-Oxohexanoyl-CoA
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:27648
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_1283f7e4_3506_4d71_989b_0faf18a3eb3d
name: HADHA
type: Species
is encoded by: hsa:3030
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: E9KL44
is: SBO:0000252
initial amount: NaN

metaR O16G2e
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110034#
product: MODEL1310110034#
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
fast: false

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
product: MODEL1310110034#

metaR r2316
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110034#
product: MODEL1310110034#

metaM aicar e
type: Species
initial concentration: 1.0
is: C04677
is: CHEBI:58475
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: SBO:0000247
is: HMDB01517
boundary condition: false
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2

metaR r2120
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110034#
type: Reaction

metaM CE2705 n
is: CHEBI:15374
type: Species
name: quinonoid dihydrobiopterin
is: HMDB02281
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
constant: false

metaR r1599
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR LDH L
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110034#
name: L-lactate dehydrogenase
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reactant: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_480a15b6_49a0_4b85_b690_f6414d359232
constant: false
boundary condition: true
is encoded by: hsa:4697
initial amount: NaN
initial concentration: NaN
name: NDUFA4
is: O00483
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_d8644e53_0831_4e7a_888b_7155b8d838e2
initial amount: NaN
constant: false
is: E7EUT4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GAPDH
is encoded by: hsa:2597
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_184d4149_eb8d_455a_973e_49b54c810c90
type: Species
has only substance units: false
is encoded by: hsa:7296
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: TXNRD1

metaR FBA2
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110034#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_8f1121d7_a0e6_4c92_a9ef_459896b01239
boundary condition: true
is: O15254
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: ACOX3
is encoded by: hsa:8310
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_83c87774_8f8b_4ddb_be0c_98c5cd713ea9
has part: Q99519
has part: P16278
type: Species
has part: P10619
has only substance units: false
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:2588
is encoded by: hsa:5476
boundary condition: true
has part: P34059
initial concentration: NaN
is encoded by: hsa:4758
is: SBO:0000297
constant: false
initial amount: NaN
is encoded by: hsa:2720

http://identifiers.org/biomodels.db/MODEL1310110034#_8f3282a2_1554_4483_9827_f32cbf7be8f1
is: Q9H0N5
has only substance units: false
constant: false
name: PCBD2
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:84105

metaR S6TASE16ly
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#

metaM ump c
constant: false
type: Species
is: HMDB00288
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: C00105
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57865
initial concentration: 1.0

metaM c5dc e
type: Species
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: glutaryl carnitine
initial amount: NaN

metaM ins c
is: CHEBI:17596
boundary condition: false
initial amount: NaN
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
is: C00294
initial concentration: 1.0
name: Inosine
constant: false
has only substance units: false
type: Species

metaR r1590
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_ff71ca82_227e_466d_9233_2249cc98fbf3
type: Species
initial concentration: NaN
is encoded by: hsa:84720
constant: false
is: SBO:0000252
is: Q8TEQ8
initial amount: NaN
name: PIGO
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_1be0b41c_530b_4d6a_97e3_ca9ab4b98de2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:219
constant: false
is: SBO:0000252
name: ALDH1B1
has only substance units: false
initial amount: NaN
type: Species
is: P30837

metaR CITtam
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
name: citrate transport, mitochondrial
fast: false
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110034#

metaM ha e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16336
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: hyaluronan

metaM lys L c
initial concentration: 1.0
is: HMDB00182
initial amount: NaN
has only substance units: false
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_e2201031_c806_497a_9454_8e4e5d3d4f01
boundary condition: true
constant: false
has only substance units: false
name: PIK3CG
is: P48736
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5294
type: Species

metaM gt1c hs g
has only substance units: false
name: GT1c
initial amount: NaN
boundary condition: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:28648

metaR S6TASE15ly
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR MTHFDm
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110034#
type: Reaction
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR r0570
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
modifier: MODEL1310110034#
reversible: true
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.3.3.2
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
fast: false

metaR LNSTLSr
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is described by: ECO:0000134
kinetic law: MODEL1310110034#
name: lanosterol synthase
is version of: http://identifiers.org/ec-code/5.4.99.7
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
reversible: false

metaR RE3628M
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3628
reversible: true

metaM CE2705 c
is: SBO:0000247
name: quinonoid dihydrobiopterin
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
is: CHEBI:52328

metaR r0610
reactant: MODEL1310110034#
type: Reaction
fast: false
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000
product: MODEL1310110034#
reversible: true
is: SBO:0000176

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.99.13
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110034#

metaR GLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
name: glycerol transport via channel
type: Reaction
fast: false
kinetic law: MODEL1310110034#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ed0b79f3_223b_4a18_87fd_33debe0a7e65
is encoded by: hsa:762
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: CA4
is: Q6FHI7
initial concentration: NaN
is: SBO:0000252
constant: false

metaR C142CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ff4b44c6_aed6_47d4_a96d_ac5ec7b43e21
boundary condition: true
is: SBO:0000252
has only substance units: false
name: DPYS
initial concentration: NaN
is encoded by: hsa:1807
initial amount: NaN
constant: false
type: Species
is: Q14117

metaM triodthy e
initial amount: NaN
is: CHEBI:18258
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
type: Species

metaM ins e
is: C00294
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
name: Inosine
is: CHEBI:17596
is: SBO:0000247
initial amount: NaN
is: HMDB00195

metaR r0611
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.3.1
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000000
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_9dfec860_3c5e_4bff_81fb_4f4d08beb8c6
type: Species
name: _R06874_1_r
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:R06874
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR RE1845C
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110034#

metaM lys L e
initial amount: NaN
is: HMDB00182
initial concentration: 1.0
is: CHEBI:32551
has only substance units: false
boundary condition: false
constant: false
name: L-lysinium(1+)
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM octa e
name: octanoate (n-C8:0)
initial amount: NaN
is: CHEBI:25646
constant: false
has only substance units: false
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C06423
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_43909637_808f_486c_a86f_b5bf9ef42a73
constant: false
is: O95497
name: VNN1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8876
has only substance units: false
boundary condition: true

metaR RE2079R
is: SBO:0000176
name: RE2079
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_1e3b8f81_7e3f_4540_a7e0_e1014ea77324
initial amount: NaN
is encoded by: hsa:4200
is: P23368
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: ME2

metaM hgentis c
is: SBO:0000247
boundary condition: false
is: HMDB00130
is: CHEBI:16169
type: Species
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
constant: false
name: homogentisate
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM lac L x
initial concentration: 1.0
type: Species
is: HMDB00190
constant: false
has only substance units: false
is: CHEBI:16651
initial amount: NaN
name: (S)-lactate
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_cdb7ca8a_d450_4af9_bd7f_b5591dbf1f39
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:56606
initial concentration: NaN
name: SLC2A9
has only substance units: false
type: Species
constant: false
is: Q9NRM0

metaM cs b deg3 l
has only substance units: false
type: Species
is: CHEBI:21338
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: HMDB02704
boundary condition: false
initial concentration: 1.0

metaR EX gq1b hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1b (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ffc24db1_7440_4ea7_9b44_74eb29caf5d0
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q6ZWT7
name: MBOAT2
is encoded by: hsa:129642
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f079c2cb_2916_4675_a9d2_0c637ce9803d
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: _AA977580_1_c
initial concentration: NaN
is encoded by: hsa:AA977580
boundary condition: true

metaR r1594
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true

metaR r2129
reactant: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reversible: true
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000

metaR GALASE10ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM HC01412 x
constant: false
is: CHEBI:61405
type: Species
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: trans-tetradec-2-enoyl-CoA(4-)

metaR r1380
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_554c4f1f_c747_449b_a01b_6e86a4ca3df3
has only substance units: false
type: Species
is: E5KSL6
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: DGUOK
is encoded by: hsa:1716

metaM 1pyr5c m
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: SBO:0000247
initial concentration: 1.0
is: C03912
type: Species
constant: false
initial amount: NaN
is: CHEBI:15893
is: HMDB01301
boundary condition: false
name: 1-Pyrroline-5-carboxylate
has only substance units: false

metaM hexdicoa r
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
is: C08260
name: hexadecanedioylcoa
is: HMDB00672
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR UMPK5n
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110034#
name: UMP kinase (dATP),nuclear
product: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM andrstrn r
is: SBO:0000247
boundary condition: false
name: androsterone
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
constant: false
is: CHEBI:16032
initial amount: NaN
has only substance units: false
is: HMDB00031
initial concentration: 1.0

metaR r1593
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#

metaM hdcea e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
constant: false
boundary condition: false
name: Hexadecenoate (n-C16:1)
is: HMDB03229
is: CHEBI:32372
type: Species

metaR KHK
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.3
name: ketohexokinase
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_33fabac0_48dd_45c5_ab41_fa0fe76a5acd
has only substance units: false
name: ACOT6
initial amount: NaN
boundary condition: true
type: Species
is: Q3I5F7
is encoded by: hsa:641372
constant: false
is: SBO:0000252
initial concentration: NaN

metaR HSD17B4x
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110034#
name: hydroxysteroid (17-beta) dehydrogenase 4
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2ce9e988_2bd2_40f6_b9ee_f77bc32cbbbd
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: PIP4K2B
is: P78356
is encoded by: hsa:8396

metaR DURAD2
product: MODEL1310110034#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction
name: dihydrothymin dehydrogenase (NADP)
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_bc403b97_efc3_4412_bf2e_253cb60e2700
name: PC
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5091
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_300ad492_a74c_4133_b280_68b9e8118d1c
has only substance units: false
boundary condition: true
initial amount: NaN
name: PEMT
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10400
initial concentration: NaN

metaR r0614
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110034#
fast: false
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_a0431bf3_6138_42b5_8706_0ccb0e82f221
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: F5GZG6
name: TPK1
is encoded by: hsa:27010
has only substance units: false

metaR r2127
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110034#
is: SBO:0000185
fast: false
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#

metaR r1592
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false

metaR CDIPTr
is described by: ECO:0000000
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
name: phosphatidylinositol synthase (Homo sapiens)
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
reactant: MODEL1310110034#

metaM cs a deg5 l
is: SBO:0000247
boundary condition: false
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110034#_fde2a47b_e56b_480c_bbbd_a205344ba8d0
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:89874
name: SLC25A21
initial amount: NaN
is: G3V4L5

metaR BTNt4i
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
kinetic law: MODEL1310110034#
fast: false
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: false
name: Biotin uptake (antiport)

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM hdcea c
has only substance units: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Hexadecenoate (n-C16:1)
constant: false
is: HMDB03229
is: CHEBI:32372

metaR CSBPASEly
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false

metaR r2128
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110034#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_e24d72e3_94d4_4c10_bd20_451e3d059d37
type: Species
initial amount: NaN
initial concentration: NaN
name: GNE
is: B7Z428
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:10020
has only substance units: false

metaR 4MOPte
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000134
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r1591
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
reversible: true

metaR O2St
is described by: ECO:0000000
type: Reaction
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
fast: false

metaR C8CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaM dcholcoa c
is: CHEBI:28701
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
type: Species
is: HMDB06292

metaM cspg d e
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan
initial concentration: 1.0
is: HMDB00630
notes: FORMULA: C45H64N2O51S5X CHARGE: -7
is: CHEBI:16040

http://identifiers.org/biomodels.db/MODEL1310110034#_034baebb_e487_4e65_86f8_365101bc1f70
has only substance units: false
type: Species
initial concentration: NaN
is: P14618
name: PKM2
boundary condition: true
is encoded by: hsa:5315
is: SBO:0000252
initial amount: NaN
constant: false

metaR OLEICFATPtc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR SPODMx
fast: false
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is: SBO:0000176
modifier: MODEL1310110034#
name: superoxide dismutase, peroxisome
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110034#

metaR ICDHxm
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.41
is described by: ECO:0000134
modifier: MODEL1310110034#
reactant: MODEL1310110034#
name: Isocitrate dehydrogenase (NAD+)
type: Reaction
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic
reversible: false
product: MODEL1310110034#

metaR r0340
fast: false
modifier: MODEL1310110034#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
product: MODEL1310110034#

metaM HC01397 x
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
boundary condition: false

metaR AHCYStd
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is described by: ECO:0000134
fast: false
reversible: true
name: diffusion of S-Adenosyl-L-homocysteine
is: SBO:0000185
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#

metaR r0578
is: SBO:0000176
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_487affa3_044e_4104_8409_02b6c60b367f
name: SLC17A4
initial concentration: NaN
is encoded by: hsa:10050
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9Y2C5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ceee1a37_525c_4c60_aebb_956bafa6b8ba
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: C9JC79
is encoded by: hsa:6342
initial amount: NaN
initial concentration: NaN
name: SCP2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c142937c_fded_47d1_b3af_836e648282e1
name: _22305_2_c
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:22305
boundary condition: true

metaM CE2250 e
initial amount: NaN
name: 3-oxodocosanoyl-CoA
is: SBO:0000247
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:52328
initial concentration: 1.0
constant: false

metaM HC02214 e
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28852
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e1194871_4367_4a94_9c74_526116f5d970
type: Species
is: SBO:0000252
boundary condition: true
is: P36969
name: GPX4
has only substance units: false
initial amount: NaN
is encoded by: hsa:2879
initial concentration: NaN
constant: false

metaM lac L c
has only substance units: false
constant: false
is: HMDB00190
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
boundary condition: false
type: Species
name: (S)-lactate

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
is: HMDB01123
initial concentration: 1.0
is: CHEBI:16567
has only substance units: false
is: SBO:0000247
boundary condition: false
name: anthranilate
constant: false
initial amount: NaN

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
name: hexokinase (D-fructose:ATP)
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c431180d_a5d4_4087_8ffa_c8b4f3ef969f
is encoded by: hsa:229
constant: false
boundary condition: true
name: ALDOB
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P05062
has only substance units: false

metaR r1851
kinetic law: MODEL1310110034#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110034#
reversible: false
product: MODEL1310110034#

metaM pydx c
is: C00250
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01545
name: Pyridoxal
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
is: CHEBI:17310

metaR r1964
modifier: MODEL1310110034#
reversible: false
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Y+LAT2 Utilized transport
type: Reaction

metaR r0604
product: MODEL1310110034#
type: Reaction
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_16b491dd_b049_4050_b190_5bd2eccead2b
has only substance units: false
is encoded by: hsa:92745
initial amount: NaN
is: SBO:0000252
is: Q8WUX1
boundary condition: true
name: SLC38A5
type: Species
initial concentration: NaN
constant: false

metaR r0129
is described by: ECO:0000000
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110034#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110034#_071692c4_528f_4066_a520_b95b8241a4cc
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: Q6P9G0
has only substance units: false
name: CYB5D1
is encoded by: hsa:124637
is: SBO:0000252
type: Species

metaR GALASE3ly
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110034#_7a067408_1710_4c01_a955_d9378fc1f4b7
is encoded by: hsa:1645
initial concentration: NaN
is: SBO:0000252
name: AKR1C1
constant: false
is: Q04828
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_bda94ea9_47e2_4d29_98f8_1922a0ce26b0
name: PIK3C2G
is: O75747
is: SBO:0000252
is encoded by: hsa:5288
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR LPASE
product: MODEL1310110034#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.5
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110034#
is described by: ECO:0000000
name: lysophospholipase
reactant: MODEL1310110034#

metaR RE2269E
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
name: RE2269
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39
type: Reaction

metaM ppp9 m
is: HMDB00241
constant: false
name: Protoporphyrin
is: SBO:0000247
boundary condition: false
is: CHEBI:36159
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
type: Species

metaR LINKDEG3ly
product: MODEL1310110034#
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_1a1aac43_3323_44e6_aaf8_7e3c24ba547d
has only substance units: false
is: P21912
boundary condition: true
name: SDHB
constant: false
initial amount: NaN
is encoded by: hsa:6390
initial concentration: NaN
is: SBO:0000252
type: Species

metaR RE1447N
is described by: ECO:0000000
name: RE1447
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true

metaM glac c
is: CHEBI:18268
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false
name: D-glucurono-6,3-lactone
initial amount: NaN
initial concentration: 1.0

metaM lac L e
is: HMDB00190
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16651
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
constant: false
name: (S)-lactate

metaM nicrns c
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58527
name: Nicotinate D-ribonucleoside
has only substance units: false
initial amount: NaN
is: HMDB06809
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_95397438_6fd5_4938_bf27_d17331a6e286
initial amount: NaN
is encoded by: hsa:8527
constant: false
has only substance units: false
is: Q16760
name: DGKD
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
product: MODEL1310110034#
type: Reaction

metaR r1966
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reversible: false
fast: false

metaM ha l
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
name: hyaluronan
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16336
initial amount: NaN
constant: false

metaM anth c
is: CHEBI:16567
is: SBO:0000247
boundary condition: false
is: HMDB01123
constant: false
type: Species
has only substance units: false
name: anthranilate
initial concentration: 1.0
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN

metaM pydx e
constant: false
has only substance units: false
name: Pyridoxal
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00250
type: Species
is: CHEBI:17310
is: HMDB01545
is: SBO:0000247
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250

metaR r0127
is described by: ECO:0000000
fast: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reactant: MODEL1310110034#
reversible: false

metaM CE2433 m
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: CHEBI:57795
initial amount: NaN
constant: false
boundary condition: false

metaR RE0453N
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
name: RE0453
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_53bdd9de_5ff3_4cc0_9ee4_90c6a1bcd66c
is: SBO:0000252
boundary condition: true
constant: false
name: ATP5G3
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:518
initial amount: NaN
is: P48201

metaR AKR1D2
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is: SBO:0000176
is described by: ECO:0000269
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.1.3
reversible: false
fast: false
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaM ksii core4 deg4 l
initial amount: NaN
is: SBO:0000247
is: HMDB00812
name: keratan sulfate II (core 4-linked), degradation product 4
initial concentration: 1.0
notes: FORMULA: C66H108N6O48SX CHARGE: -1
type: Species
is: CHEBI:16953
constant: false
boundary condition: false
has only substance units: false

metaR GPIAT
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
name: glucosaminylphosphatidyl inositol acetyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176

metaR r1375
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
fast: false
kinetic law: MODEL1310110034#
name: Transport reaction
reversible: false

metaR SMS
type: Reaction
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
reactant: MODEL1310110034#
is: SBO:0000176
name: Sphingomyelin synthase (homo sapiens)
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.27

metaR GALASE7ly
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reversible: false
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM lys L x
boundary condition: false
is: SBO:0000247
name: L-lysinium(1+)
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00182
initial concentration: 1.0

metaR HEX1
reversible: false
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: hexokinase (D-glucose:ATP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
is described by: ECO:0000134
type: Reaction

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM 3hpp m
is: CHEBI:16510
is: SBO:0000247
name: 3-hydroxypropionate
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: HMDB00700
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaR SGPL12r
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000176
name: Sphingosine-1-phosphate lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is described by: ECO:0000304
reactant: MODEL1310110034#

metaR ASPGLUm
modifier: MODEL1310110034#
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_94a6aa94_b245_4e19_8b5a_d7b89a32ffc6
is encoded by: hsa:4514
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P00414
type: Species
name: COX3
constant: false

metaM HC00319 c
initial concentration: 1.0
boundary condition: false
name: Malonate
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaR ASPTAm
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
name: aspartate transaminase
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR NTP3e
fast: false
name: nucleoside-triphosphatase (GTP)
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR PCHOLPm hs
modifier: MODEL1310110034#
fast: false
name: choline phosphatase
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
is described by: ECO:0000269
type: Reaction

metaR DHCR71r
reversible: false
name: 7-dehydrocholesterol reductase
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
fast: false
modifier: MODEL1310110034#

metaM leuktrB4 e
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
is: CHEBI:57461
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: leukotriene B4(1-)
has only substance units: false

metaR HEXDIACTD
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_718c6518_ecca_4638_a891_511f02435386
name: _AA526438_1_m
is encoded by: hsa:AA526438
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR C120CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_1ace6ed2_cc06_4a12_9e75_4153e9652991
is: G3V0F6
constant: false
is encoded by: hsa:8525
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110034#_b271304d_885a_49c9_b00c_659f339b6e3b
is encoded by: hsa:9380
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: GRHPR
constant: false
initial concentration: NaN
has only substance units: false
is: Q9UBQ7

metaM c5dc c
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: glutaryl carnitine
notes: FORMULA: C12H21NO6 CHARGE: 0
is: HMDB13130
type: Species

metaM gm3 hs g
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: SBO:0000247
type: Species
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
is: CHEBI:60065
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2a0284b3_50a2_432b_89ad_abd529f4bac6
has only substance units: false
name: _BE042354_1_m
type: Species
is: SBO:0000252
is encoded by: hsa:BE042354
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM udpglcur r
type: Species
is: C00167
initial concentration: 1.0
name: UDP-D-glucuronate
has only substance units: false
is: SBO:0000247
is: HMDB00935
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052

metaM 2dr5p c
name: 2-deoxy-D-ribose 5-phosphate(2-)
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01031
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_d80bacdc_697b_4ddc_ad8c_b0a009b86308
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:22978
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P49902
name: NT5C2
constant: false

metaR CITtbm
type: Reaction
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
name: citrate transport, mitochondrial
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_6be10744_962e_403b_bbbb_6efaf44b0c3a
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: P09960
name: LTA4H
initial amount: NaN
has only substance units: false
is encoded by: hsa:4048

metaM HC02214 c
has only substance units: false
is: CHEBI:28852
is: SBO:0000247
name: prostaglandin-f1alpha
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1

metaR MI14Ptn
fast: false
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0579
reversible: true
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is: SBO:0000176
product: MODEL1310110034#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaR HEX4
is described by: ECO:0000304
reversible: false
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-mannose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
product: MODEL1310110034#

metaR r2014
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110034#
reversible: false
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110034#
type: Reaction

metaR r2130
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GALGT2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.92
modifier: MODEL1310110034#
name: Beta-1,4 N-acetylgalactosaminyltransferase

metaR FAS180COA
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C18:0CoA)
reversible: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_59270506_aec6_41d8_8fd7_8cb30d128c6a
name: BPNT1
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O95861
is encoded by: hsa:10380
constant: false
initial amount: NaN

metaR LALDO2x
is described by: ECO:0000269
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
reversible: false
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

metaR r2318
reversible: true
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM man l
name: D-mannose
is: HMDB00169
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false

metaR NACHEX7ly
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110034#
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110034#
is: SBO:0000176

metaR B3GALTg
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000176
type: Reaction
name: Beta galactosyltransferase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ

metaM leuktrB4 c
constant: false
initial amount: NaN
is: CHEBI:57461
is: HMDB01085
type: Species
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM asn L c
is: CHEBI:17196
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
name: L-asparagine
initial amount: NaN
is: SBO:0000247
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110034#_a68057af_69c4_49eb_ae8c_93a79f41e085
name: _AV713053_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AV713053
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR r1859
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GALGT3
reversible: false
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.1.92
is: SBO:0000176
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110034#
name: Beta-1,4 N-acetylgalactosaminyltransferase
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ

metaR RE2814R
fast: false
name: RE2814
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
product: MODEL1310110034#

metaR r0717
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
kinetic law: MODEL1310110034#

metaR r2317
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110034#
is: SBO:0000185

metaR SPODMn
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
reactant: MODEL1310110034#
name: superoxide dismutase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110034#_6482fccf_93d4_4ec3_bb26_7d113f8f2f69
is: SBO:0000252
is: Q9BYZ2
type: Species
constant: false
has only substance units: false
is encoded by: hsa:92483
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: LDHAL6B

metaM andrstrn e
name: androsterone
is: HMDB00031
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: CHEBI:16032

http://identifiers.org/biomodels.db/MODEL1310110034#_6730bfc4_b940_4c1d_83e6_79ac2961a45e
has only substance units: false
boundary condition: true
type: Species
constant: false
is: Q75T13
name: PGAP1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80055

http://identifiers.org/biomodels.db/MODEL1310110034#_13f1e34b_beca_446d_88cb_af986c169cc2
name: GALNS
constant: false
type: Species
is: P34059
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2588
boundary condition: true

metaR PI345P5P
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction
is: SBO:0000176
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#

metaM gq1balpha hs g
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: C00249
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00220
is: SBO:0000247
is: CHEBI:7896
name: GQ1balpha
initial concentration: 1.0

metaR SPODMm
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000304
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
name: superoxide dismutase
is version of: http://identifiers.org/ec-code/1.15.1.1

metaR GALGT4
reactant: MODEL1310110034#
name: Beta-1,4 N-acetylgalactosaminyltransferase
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.1.92
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000269

metaM chol c
is: SBO:0000247
is: C00114
is: HMDB00097
name: Choline
constant: false
boundary condition: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_0b6a4cd0_953f_40a6_9aa3_559d2932fc44
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:570
is: Q14032
boundary condition: true
name: BAAT
constant: false

metaR r1377
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110034#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
fast: false
product: MODEL1310110034#
is: SBO:0000176
reversible: true

metaR GLNS
is described by: ECO:0000254
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
name: glutamine synthetase
product: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_25054291_49ed_4033_95a2_7afa42e5d65c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA419122
is: SBO:0000252
name: _AA419122_1_c
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaM uppg3 c
type: Species
has only substance units: false
name: Uroporphyrinogen III
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01086
is: CHEBI:57308
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
boundary condition: false
is: C01051
initial concentration: 1.0

metaM mag hs c
initial amount: NaN
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
is: CHEBI:16987
boundary condition: false
is: SBO:0000247
is: HMDB12130
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_7500653d_ed1b_4a18_bff0_dca4370c9ce9
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ADCY4
is: SBO:0000252
is: Q8NFM4
is encoded by: hsa:196883
constant: false
boundary condition: true

metaR r2319
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
reactant: MODEL1310110034#
fast: false

metaR CERT2gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
fast: false
product: MODEL1310110034#
name: ceramide transport protein
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
type: Reaction
modifier: MODEL1310110034#

metaR r0719
reversible: false
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.153
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

http://identifiers.org/biomodels.db/MODEL1310110034#_e446f8cd_3362_4ca2_98d1_71eecf28eb54
boundary condition: true
is: P28329
has only substance units: false
initial concentration: NaN
constant: false
name: CHAT
is encoded by: hsa:1103
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1378
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000176
reversible: true
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110034#

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM chol e
is: HMDB00097
type: Species
is: C00114
boundary condition: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: CHEBI:15354
is: SBO:0000247
constant: false
initial amount: NaN
name: Choline

metaM gq1balpha hs e
name: GQ1balpha
has only substance units: false
type: Species
is: CHEBI:58115
is: SBO:0000247
constant: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01397

http://identifiers.org/biomodels.db/MODEL1310110034#_4b42afd4_2625_4c94_ad0f_27480d2176cf
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P07327
name: ADH1A
is encoded by: hsa:124
initial amount: NaN

metaM HC00319 m
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:30794
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
initial concentration: 1.0
type: Species
name: Malonate

http://identifiers.org/biomodels.db/MODEL1310110034#_6dea31b6_06d0_44e7_ad4e_d4d193c2cfd0
initial amount: NaN
boundary condition: true
constant: false
is: Q06055
is: SBO:0000252
has only substance units: false
name: ATP5G2
type: Species
initial concentration: NaN
is encoded by: hsa:517

http://identifiers.org/biomodels.db/MODEL1310110034#_974bf4aa_31cb_4c5f_8e08_4098a2b68cc2
is encoded by: hsa:84264
initial amount: NaN
constant: false
initial concentration: NaN
name: HAGHL
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110034#
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
name: ribulose 5-phosphate 3-epimerase
fast: false

metaR RBTt
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: ribitol transport via passive diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000000

metaM gumtchol e
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
name: guar gum-taurocholic acid complex
type: Species
is: HMDB00626
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR C6DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_6aab12ca_6a94_40ea_bbfe_a6bdc32d2c45
is encoded by: hsa:NM 001929
has only substance units: false
is: SBO:0000252
name: _NM_001929_1_c
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5473e288_af38_413e_8d94_9697b0324989
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: P49902
is: SBO:0000252
is encoded by: hsa:22978
initial amount: NaN
name: NT5C2
constant: false

metaR FUM
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
reversible: true
name: fumarase
is version of: http://identifiers.org/ec-code/4.2.1.2
reactant: MODEL1310110034#

metaM HC02206 c
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57399
constant: false
initial amount: NaN
name: prostaglandin C1(1-)
boundary condition: false

metaR r2532
product: MODEL1310110034#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_944ab145_e134_40cf_a8e3_181f011db4ca
name: DUT
has only substance units: false
is encoded by: hsa:1854
boundary condition: true
type: Species
initial concentration: NaN
is: P33316
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_13799990_e0b6_4846_926c_cd4e91158240
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:H45672
name: _H45672_1_m
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_f9700c70_81c9_44fa_a59c_12e46068766e
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: ECHS1
has only substance units: false
is: P30084
boundary condition: true
is encoded by: hsa:1892
constant: false

metaR RE1447M
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: RE1447

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ba94f152_c316_4235_9632_eb578461c91b
constant: false
type: Species
has only substance units: false
is: Q08499
is encoded by: hsa:5144
name: PDE4D
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM kynate c
name: kynurenate
is: CHEBI:58454
boundary condition: false
is: HMDB00715
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247
initial amount: NaN
type: Species

metaM mag hs e
has only substance units: false
is: SBO:0000247
name: monoacylglycerol 2
type: Species
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:60479
initial concentration: 1.0
initial amount: NaN

metaR CHSTEROLt1
fast: false
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110034#
name: cholesterol intracellular transport
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true

metaR B3GNT51g
reactant: MODEL1310110034#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
product: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_4305be88_880a_4f0b_aee5_33c8f6677f23
is: B7Z4Y6
type: Species
initial concentration: NaN
name: ALPL
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:249

http://identifiers.org/biomodels.db/MODEL1310110034#_8f08049e_e200_4f77_b73b_e71f03e9215b
type: Species
initial concentration: NaN
constant: false
name: CPT1B
is: E9PCP2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1375

metaR r2534
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#

metaR ENO
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
name: enolase
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.11
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
reversible: true
fast: false

metaM gq1balpha hs c
initial amount: NaN
type: Species
is: CHEBI:7896
is: SBO:0000247
constant: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: HMDB00220
name: GQ1balpha
has only substance units: false
is: C00249

metaM mi134p c
is: HMDB01143
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial concentration: 1.0
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:58414

metaR RE3273C
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
type: Reaction
fast: false
name: RE3273
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176

metaR CHSTEROLt2
reversible: true
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000000

metaM xylu L c
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB00751
boundary condition: false
name: L-xylulose
is: CHEBI:17399
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267

metaM HC02206 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial concentration: 1.0
is: CHEBI:57399
has only substance units: false
initial amount: NaN
name: prostaglandin C1(1-)
boundary condition: false
type: Species
is: SBO:0000247

metaR RETH2e
fast: false
is: SBO:0000176
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
type: Reaction
name: retinyl ester hydrolase (11-cis), extracellular
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110034#_77a658b0_3714_412d_8bf8_bdaab230f39b
has only substance units: false
is: B4DYG5
is encoded by: hsa:5297
name: PI4KA
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR SPHMYLNtg
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
is described by: ECO:0000000
name: sphingomyelin intracellular transport
product: MODEL1310110034#

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
name: hexaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110034#_eb41b927_bf92_4ecc_b7ff_49f90e0d1819
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3158
initial concentration: NaN
boundary condition: true
type: Species
name: HMGCS2
is: P54868
constant: false

metaR RE0453C
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
is: SBO:0000176
name: RE0453

metaR RE2814M
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_620a97ee_16cc_44ac_ae20_d9d3f81e605c
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _MBOAT5_1_c
initial amount: NaN
is encoded by: hsa:MBOAT5

http://identifiers.org/biomodels.db/MODEL1310110034#_e1501c43_3b10_4d6e_9565_ac27271aded0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3417
name: IDH1
type: Species
constant: false
initial amount: NaN
is: O75874

metaM andrstrn c
boundary condition: false
has only substance units: false
is: HMDB00031
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species
constant: false
is: CHEBI:16032
name: androsterone

metaR r0715
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110034#
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#

metaR CHSTEROLt3
product: MODEL1310110034#
type: Reaction
name: cholesterol intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
is: SBO:0000185
reversible: true

metaR GALGT1
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES:NJ
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
name: Beta-1,4 N-acetylgalactosaminyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.92
modifier: MODEL1310110034#

metaM ksii core2 l
type: Species
is: HMDB00189
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial concentration: 1.0
is: CHEBI:57614
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 2-linked)
initial amount: NaN

metaM asn L e
is: HMDB00168
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
is: SBO:0000247
name: L-asparagine
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17196
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_10479f31_811c_43f1_b258_c952aae9f7f2
initial amount: NaN
is: O43252
initial concentration: NaN
name: PAPSS1
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:9061
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_63848361_37db_4dbf_83f5_c5958de55b8a
is: SBO:0000252
type: Species
is: Q7KYS4
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PDE4C
is encoded by: hsa:5143
initial amount: NaN
constant: false

metaR PAIL45P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
fast: false
type: Reaction
reactant: MODEL1310110034#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

metaM HC02121 c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
type: Species
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
boundary condition: false

metaR ST6GALNAC31
kinetic law: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (256435.1) or (30815.1) or (81849.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110034#

metaR r0474
product: MODEL1310110034#
fast: false
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_949de593_f64f_4c2b_a9cb_57a0643530e6
has only substance units: false
is encoded by: hsa:1962
constant: false
initial concentration: NaN
is: SBO:0000252
name: EHHADH
is: Q9NY65
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9493cca8_ee96_465a_a43d_c40551c7b823
type: Species
has only substance units: false
name: RRM1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P23921
is: SBO:0000252
is encoded by: hsa:6240
constant: false

metaM f1a g
is: SBO:0000247
is: CHEBI:17151
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
name: F1alpha
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
initial amount: NaN

metaR r2323
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110034#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
fast: false
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_68f5bafd_df29_444e_977b_99b360522281
boundary condition: true
name: FASN
is: P49327
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2194

metaM man c
boundary condition: false
initial concentration: 1.0
is: HMDB00169
name: D-Mannose
type: Species
constant: false
is: C00159
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial amount: NaN
is: SBO:0000247

metaR r2111
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110034#

metaR r0475
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_11bf5f2b_c491_4054_b20a_dce03d718c8e
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8869
is: Q9UNP4
name: ST3GAL5

http://identifiers.org/biomodels.db/MODEL1310110034#_fce87ec1_b431_4b17_995f_107db1c67fd8
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2582
has only substance units: false
name: GALE
is: Q14376

metaR 2HBO
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR r2324
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
product: MODEL1310110034#

metaR LEUTAm
type: Reaction
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110034#
name: leucine transaminase, mitochondrial

metaR MAL Lte
reversible: true
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110034#
type: Reaction
name: Transport of L-malate
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110034#

metaM prpp e
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
has only substance units: false
is: HMDB00280
initial amount: NaN
is: CHEBI:58017
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_cfad61d8_851f_4fb0_bd5c_0418a5e759e8
name: _AI934540_1_c
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AI934540
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_4bdb2961_7975_48b3_a363_6f8ce81e0a29
initial concentration: NaN
is encoded by: hsa:154091
is: Q8TD20
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: SLC2A12
constant: false
is: SBO:0000252

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00812
type: Species
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial amount: NaN
has only substance units: false
is: CHEBI:16953
boundary condition: false

metaR r2112
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#

metaR UMPK2
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110034#_70d74b3e_8cfe_4b5e_8eec_eaba73f1721d
boundary condition: true
name: _AA788780_1_c
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AA788780
initial concentration: NaN
has only substance units: false
constant: false

metaR r2321
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ksi deg34 l
initial amount: NaN
has only substance units: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
boundary condition: false
is: SBO:0000247
is: CHEBI:16953
type: Species
name: keratan sulfate I, degradation product 34
initial concentration: 1.0
constant: false
is: HMDB00812

metaR LINKDEG4ly
is described by: ECO:0000000
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#

metaM dd2coa x
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial concentration: 1.0
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
is: CHEBI:57330
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: HMDB03712

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

metaR r2113
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM glyb c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:17750
name: glycine betaine

http://identifiers.org/biomodels.db/MODEL1310110034#_826ecb7e_7195_4de9_834c_9630072be84f
is: SBO:0000297
has part: Q06055
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:517
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM dgsn c
is: C00330
has only substance units: false
name: Deoxyguanosine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
type: Species
is: CHEBI:17172
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_715a56ef_c05f_42d8_86ac_b02356e6a105
initial concentration: NaN
is encoded by: hsa:4357
has only substance units: false
type: Species
name: MPST
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: P25325

metaR S4TASE2ly
fast: false
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
reversible: true
type: Reaction
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110034#

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM 3hbcoa m
constant: false
type: Species
is: CHEBI:57316
is: HMDB01166
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
has only substance units: false
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0

metaR r2322
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
reversible: true

metaM mgacpail hs r
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00220
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
type: Species
is: CHEBI:7896
has only substance units: false
is: C00249
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_3812038c_e043_45b0_b59f_a79516ad3ac7
has part: P09622
is encoded by: hsa:4967
boundary condition: true
has only substance units: false
is encoded by: hsa:1738
constant: false
has part: Q02218
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:8050
has part: O00330
is encoded by: hsa:1743
initial amount: NaN
has part: P36957
type: Species
is: SBO:0000297

metaR KSItly
type: Reaction
reversible: false
is described by: ECO:0000000
name: keratan sulfate I transport, extracellular to lysosome
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR SO4tl
name: Sulfate transport (lysosome)
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#

metaR S6TASE17ly
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110034#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
reactant: MODEL1310110034#

metaR SO4OXAtex2
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
name: sulfate transport via oxalate countertransport (2:1)
is described by: ECO:0000304
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false

metaR r2114
product: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110034#

metaR C4STMO2Pr
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
fast: false
name: C-4 methyl sterol oxidase

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_4c14ebab_4d70_435b_9912_4b3f2c5ee22c
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P14550
is encoded by: hsa:10327
initial amount: NaN
type: Species
name: AKR1A1
boundary condition: true

metaR C3STDH1Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
reversible: false

metaR GALtly
type: Reaction
reversible: false
is: SBO:0000185
fast: false
name: galactose efflux from lysosome
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000

metaR LTC4CP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
name: Leukotriene C4 carboxypeptidase
type: Reaction

metaR GLCAASE6ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false

metaR ACt2r
is described by: ECO:0000000
name: acetate reversible transport via proton symport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
fast: false

metaM ala D c
is: SBO:0000247
constant: false
name: D-alanine
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15570
is: HMDB01310
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_5e58f837_8039_4366_9edf_8f769f7a3fcb
is encoded by: hsa:84720
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: PIGO
is: SBO:0000252
boundary condition: true
type: Species

metaM dtmp c
is: C00364
is: CHEBI:26999
constant: false
is: SBO:0000247
is: HMDB01227
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
type: Species

metaR CHOLtu
reactant: MODEL1310110034#
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000185
name: Choline uniport
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaR r0470
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_d3071c32_3c20_4bc5_b2c9_899e6714a50d
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: SLC24A4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:123041
is: SBO:0000252

metaR UMPK5
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110034#
is: SBO:0000176
name: UMP kinase (dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d64f53e6_afbf_47a2_be25_49f6ec877006
type: Species
constant: false
boundary condition: true
name: ADSSL1
has only substance units: false
is encoded by: hsa:122622
initial concentration: NaN
is: Q8N142
initial amount: NaN
is: SBO:0000252

metaM chol n
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
name: choline
is: CHEBI:15354
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM glyb e
boundary condition: false
name: glycine betaine
is: HMDB00043
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species

metaM sT antigen g
notes: FORMULA: C25H40N2O18X CHARGE: -1
constant: false
boundary condition: false
name: sialyl-T antigen
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16565
is: SBO:0000247
initial concentration: 1.0

metaR r2327
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000185

metaR HXPRT
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_991585f0_8697_4ea6_b906_8ad054dd6538
type: Species
has only substance units: false
name: SLC17A1
is: Q14916
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6568
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_829f905d_ce02_46c7_a844_d452963abdef
name: SLC35A2
initial concentration: NaN
has only substance units: false
is: P78381
is: SBO:0000252
type: Species
is encoded by: hsa:7355
constant: false
initial amount: NaN
boundary condition: true

metaM 34dhoxmand c
is: HMDB01866
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
is: SBO:0000247
initial amount: NaN

metaM f1a l
is: SBO:0000247
name: F1alpha
has only substance units: false
type: Species
is: CHEBI:17151
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: HMDB02917
boundary condition: false

metaM dhap x
name: Dihydroxyacetone phosphate
is: SBO:0000247
boundary condition: false
is: CHEBI:57642
is: C00111
is: HMDB01473
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411

metaM acgal l
type: Species
is: HMDB00212
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
name: N-acetyl-D-galactosamine
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM ksii core2 e
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
is: CHEBI:17268
initial amount: NaN
constant: false
is: HMDB00211
initial concentration: 1.0
has only substance units: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR UMPK6
name: UMP kinase (dCTP)
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
reversible: true
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110034#
type: Reaction

metaR INSTt2r
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
fast: false
name: inositol transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110034#
reversible: true

metaR RAI2
reversible: true
name: retinal isomerase (9-cis)
reactant: MODEL1310110034#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110034#

metaR r2328
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR RE1532M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1532
is described by: ECO:0000000
is: SBO:0000176
reversible: true
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM dtmp e
constant: false
is: CHEBI:26999
is: SBO:0000247
is: HMDB01227
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
initial concentration: 1.0
name: dTMP(2-)
boundary condition: false
type: Species

metaR HMGCOARc
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
reversible: false
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol

metaM ala D e
initial concentration: 1.0
constant: false
initial amount: NaN
name: D-alanine
type: Species
is: CHEBI:15570
is: HMDB01310
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
is: SBO:0000247

metaM tdcoa c
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
is: SBO:0000247
is: HMDB01521
boundary condition: false
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
is: C02593
is: CHEBI:57385
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_9329a8e3_7777_41bc_961e_5e880d195e5a
has only substance units: false
name: HADH
initial concentration: NaN
is: Q16836
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3033

metaR r0472
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
fast: false

metaM udpglcur c
boundary condition: false
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: CHEBI:58052
has only substance units: false
is: HMDB00935
initial concentration: 1.0
type: Species
name: UDP-D-glucuronate
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_6188b2cf_6ae6_4607_a385_dfad2a50aeb5
is: P30038
has only substance units: false
boundary condition: true
name: ALDH4A1
is encoded by: hsa:8659
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR PPBNGS
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.24
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110034#
reversible: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000176
name: porphobilinogen synthase

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_8061ba3d_1c29_44c0_bd43_d44d28487f71
type: Species
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
is: Q02218
constant: false
name: OGDH
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_75ceb4d4_1d63_40cb_876e_824042aecd7e
is: SBO:0000252
is encoded by: hsa:4726
initial concentration: NaN
name: NDUFS6
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: Q6IBC4

metaM glac r
is: CHEBI:18268
is: SBO:0000247
initial amount: NaN
name: D-glucurono-6,3-lactone
has only substance units: false
type: Species
is: HMDB06355
initial concentration: 1.0
constant: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
boundary condition: false

metaR UMPK3
modifier: MODEL1310110034#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: UMP kinase (UTP)
reactant: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_6d0b2d59_4c78_4d11_a077_35cbeac72cac
initial concentration: NaN
is encoded by: hsa:6569
name: SLC34A1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: Q7Z725
initial amount: NaN

metaR PAPtg
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: adenosine 3',5'-bisphosphate Golgi transport
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
reversible: false

metaR NRPPHRtu
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Norepinephrine uniport
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#

metaR RE0915E
name: RE0915
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR r2325
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_35d115c7_aa4a_4f76_b8ea_86ba4b35bb70
boundary condition: true
is: Q9H2X9
is encoded by: hsa:57468
initial amount: NaN
name: SLC12A5
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR O16G1e
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular

http://identifiers.org/biomodels.db/MODEL1310110034#_22684dea_4fbf_4a82_9468_21d59d702aa8
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: FPGT
constant: false
is: O14772
is encoded by: hsa:8790

http://identifiers.org/biomodels.db/MODEL1310110034#_9bcf0a7d_b959_449a_9f38_a3d1b54dab2c
initial amount: NaN
is encoded by: hsa:28976
name: ACAD9
is: SBO:0000252
is: Q9H845
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR UMPK4
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: UMP kinase (GTP)

metaR r2110
modifier: MODEL1310110034#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000

metaR C4STMO1r
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
reactant: MODEL1310110034#

metaM chol m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false
name: choline
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:15354
is: HMDB00097

http://identifiers.org/biomodels.db/MODEL1310110034#_ee692764_63ef_4c40_8a34_773e5e8e8eee
is encoded by: hsa:4702
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: B1AM93
boundary condition: true
type: Species
name: NDUFA8

metaR APOC LYS BTNPm
fast: false
is: SBO:0000176
product: MODEL1310110034#
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction
reversible: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#

metaR r2326
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110034#_53088fbe_20db_4572_9941_c195f8775620
boundary condition: true
is encoded by: hsa:6120
initial concentration: NaN
constant: false
name: RPE
is: SBO:0000252
has only substance units: false
is: Q96AT9
initial amount: NaN
type: Species

metaR MI145PP
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56

metaM CE2432 m
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57795
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
type: Species
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial amount: NaN
initial concentration: 1.0

metaR PHEMEt
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
name: heme transport
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
modifier: MODEL1310110034#
is described by: ECO:0000269

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
name: phosphatidylinositol 3-kinase
product: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.137
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR S6TASE18ly
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_8fea30c8_c0d5_452e_8de2_baebde851564
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64064
name: OXCT2
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q9BYC2
type: Species

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM cs b deg1 l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: CHEBI:16953
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
constant: false
is: HMDB00812
boundary condition: false
is: SBO:0000247
type: Species

metaR r2119
product: MODEL1310110034#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110034#

metaM leuktrA4 e
has only substance units: false
initial amount: NaN
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01337
constant: false
initial concentration: 1.0
name: leukotriene A4(1-)

metaM pan4p c
is: HMDB01416
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: Pantetheine 4'-phosphate
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C01134

http://identifiers.org/biomodels.db/MODEL1310110034#_31f1869f_892f_43fe_ad81_8893d5e6a302
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5321
name: PLA2G4A
constant: false
is: SBO:0000252
is: P47712
initial amount: NaN
type: Species

metaR FALDH
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.1
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
fast: false
is: SBO:0000176
modifier: MODEL1310110034#

metaM dd2coa m
is: HMDB03712
has only substance units: false
type: Species
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: trans-dodec-2-enoyl-CoA(4-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_cc7c8e36_118d_4d90_8dc6_2847e75d436f
initial amount: NaN
type: Species
name: NDUFA11
constant: false
is encoded by: hsa:126328
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: C9JT23

metaR CYANt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110034#
type: Reaction

metaR It
reactant: MODEL1310110034#
fast: false
name: Iodide uniport
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_952292ec_1dec_4f8f_985f_5dd080deb84e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: Q9NWU1
name: OXSM
is encoded by: hsa:54995

metaM glx c
is: HMDB00119
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
initial amount: NaN
is: SBO:0000247
constant: false

metaR CSPG Atly
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
reversible: false
reactant: MODEL1310110034#
type: Reaction

metaR RE3627M
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
name: RE3627
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#

metaR r0580
reversible: true
modifier: MODEL1310110034#
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false

metaR STS1
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.6.2
name: Steryl-sulfatase
is: SBO:0000176
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
fast: false

metaR RTOTAL2FATPc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR EX andrstrn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Androsterone exchange
type: Reaction

metaR UMPK7
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
name: UMP kinase (dGTP)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR UDPGLCter
reversible: true
fast: false
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185

metaM pan4p e
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: C01134
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2
constant: false
name: Pantetheine 4'-phosphate
has only substance units: false
is: HMDB01416
boundary condition: false

metaM lald D c
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17167
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
name: (R)-lactaldehyde

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_4f95c8a9_1032_411a_8ea0_331e7186d5e4
boundary condition: true
is: SBO:0000252
type: Species
is: Q9Y259
initial amount: NaN
has only substance units: false
name: CHKB
is encoded by: hsa:1120
constant: false
initial concentration: NaN

metaM tetdec2crn c
boundary condition: false
name: tetradecadienoyl carnitine
is: HMDB02014
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H37NO4 CHARGE: 0
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR ACNAM9PL
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reversible: false
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is described by: ECO:0000269
product: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.56
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

metaM omhpal r
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06294
type: Species
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0
boundary condition: false
name: w-hydroxypalmiticacid
initial amount: NaN

metaR ACCOAC
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e9a46627_e9c4_49f2_b26a_ebf61f56b9bc
has only substance units: false
boundary condition: true
is encoded by: hsa:AI926493
is: SBO:0000252
initial concentration: NaN
name: _AI926493_1_m
constant: false
initial amount: NaN
type: Species

metaR CHOLtn
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Choline transport, nuclear through pores
reactant: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_7f95bfe5_00e9_49e8_926e_9e1bf8bddc42
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: HMGCS1
constant: false
is encoded by: hsa:3157
type: Species
is: Q01581
is: SBO:0000252
has only substance units: false

metaM glyb m
boundary condition: false
name: glycine betaine
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
is: HMDB00043
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_b2781ba6_717d_4379_bb58_931e2beb9097
has only substance units: false
name: SLC4A10
is: B7Z1R0
type: Species
is encoded by: hsa:57282
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_54411f3f_3f90_4a18_b394_83d9e213f0cc
boundary condition: true
name: AK1
has only substance units: false
type: Species
is encoded by: hsa:203
is: P00568
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_bbcb4bd4_a250_4602_9a2e_cf0b01eca846
is: Q14642
type: Species
is: SBO:0000252
boundary condition: true
name: INPP5A
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:3632

http://identifiers.org/biomodels.db/MODEL1310110034#_5b7486d4_7ffc_45c1_b898_0a92a9c941de
boundary condition: true
is: P56181
name: NDUFV3
has only substance units: false
initial amount: NaN
is encoded by: hsa:4731
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_2fc8393b_e33b_470e_a60b_02b2641e0385
type: Species
is: SBO:0000252
is encoded by: hsa:81849
is: Q9BVH7
name: ST6GALNAC5
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM dgsn e
is: C00330
is: HMDB00085
type: Species
constant: false
is: CHEBI:17172
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
has only substance units: false

metaR r2115
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM acgal c
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
constant: false
is: CHEBI:28037
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: N-acetyl-D-galactosamine

metaR SRTNtu
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110034#
is: SBO:0000185
reversible: true
name: Serotonin uniport
product: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000269

metaM xoltetrol c
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial amount: NaN
is: HMDB01231
boundary condition: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17278

metaM trdox c
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Oxidized thioredoxin
type: Species
is: C00343

metaM 4mop m
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:17865
initial concentration: 1.0
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

http://identifiers.org/biomodels.db/MODEL1310110034#_757c22cc_c7c1_4a50_9c6f_18a4049be3c3
name: DGKH
type: Species
has only substance units: false
is encoded by: hsa:160851
is: Q86XP1
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR PSSA1 hs
modifier: MODEL1310110034#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#
name: Phosphatidylserine synthase homo sapiens
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9e66985a_d774_4325_a004_0349fa53d998
name: HIBCH
initial concentration: NaN
is encoded by: hsa:26275
constant: false
initial amount: NaN
is: Q6NVY1
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_bfb60c69_acf9_4728_90fe_e221d120f6a2
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: Q6FH48
boundary condition: true
name: ASPA
is encoded by: hsa:443

metaR r0603
kinetic law: MODEL1310110034#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#

metaR LTA4H
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
name: Leukotriene A-4 hydrolase
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_546a72f8_195d_431d_bcd0_c914ab3fc87c
initial concentration: NaN
initial amount: NaN
is: Q9GZV3
boundary condition: true
name: SLC5A7
has only substance units: false
is encoded by: hsa:60482
constant: false
type: Species
is: SBO:0000252

metaR AACOAT
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Acetoacetyl-CoA:acetate CoA-transferase
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaR r2320
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110034#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM gchola c
name: glycocholate
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: HMDB00138
is: CHEBI:58235
initial amount: NaN
type: Species

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
fast: false
reactant: MODEL1310110034#

metaR r2116
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110034#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110034#
fast: false
is described by: ECO:0000000

metaR r0584
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
fast: false
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is: SBO:0000176
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true

metaR UMPK6n
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110034#
reversible: true
kinetic law: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_834b611b_817d_4f5d_8873_94b268c455d8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51205
initial concentration: NaN
name: ACP6
boundary condition: true
type: Species
has only substance units: false
is: Q9NPH0
constant: false

metaM 10fthf5glu e
name: 10-formyltetrahydrofolate-[Glu](5)
type: Species
is: CHEBI:58190
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false
is: HMDB00224
initial concentration: 1.0

metaR r0339
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110034#_85130d62_cee4_4ff4_8cee_06f9f32f2ae0
has only substance units: false
is encoded by: hsa:4597
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: MVD
initial concentration: NaN
is: P53602
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_756831c1_c3ac_4f50_8961_4c090b13ccae
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: F8VQS7
boundary condition: true
is encoded by: hsa:55967
name: NDUFA12
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2ea597a8_d3a0_4f7a_bcf1_6218e5ea0a4f
is: Q9H6Y6
is: SBO:0000252
is encoded by: hsa:4645
initial concentration: NaN
type: Species
constant: false
name: MYO5B
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_ad4dde5d_4a3a_4795_856e_0eb03d226374
boundary condition: true
is encoded by: hsa:2271
initial amount: NaN
initial concentration: NaN
name: FH
is: SBO:0000252
constant: false
is: P07954
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_762886a0_7c06_45ed_a0f0_87ce4005f7d9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _AD000092_1_c
constant: false
is encoded by: hsa:AD000092
type: Species
has only substance units: false

metaR NACHEX23ly
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110034#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaM leuktrA4 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57463
name: leukotriene A4(1-)
is: HMDB01337
type: Species
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false

metaR r2117
product: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_e63ceacb_a3ad_4e7b_a3a6_9a25cdf40172
is encoded by: hsa:206
initial amount: NaN
name: _206_1_c
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR HIVCACBP
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM hco3 m
is: HMDB00595
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false
is: C00288
boundary condition: false
type: Species
initial amount: NaN
name: Bicarbonate
is: CHEBI:17544

http://identifiers.org/biomodels.db/MODEL1310110034#_9d3d637b_06cf_410a_b57a_7d141db40536
boundary condition: true
name: AMY2B
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:280
initial amount: NaN
has only substance units: false
is: P19961
type: Species
constant: false

metaM prpp c
is: C00119
type: Species
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017
initial amount: NaN
is: HMDB00280

metaM gchola e
notes: FORMULA: C26H43NO6 CHARGE: 0
constant: false
boundary condition: false
name: glycocholate
has only substance units: false
initial concentration: 1.0
is: HMDB00138
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_e7bf5166_f8f7_449f_aec3_17a608c640b9
has part: P05496
is encoded by: hsa:9551
has part: Q08ET0
is encoded by: hsa:10476
is encoded by: hsa:522
is encoded by: hsa:10632
initial concentration: NaN
has part: P56385
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false
is encoded by: hsa:515
has part: P46459
initial amount: NaN
boundary condition: true
is encoded by: hsa:521
constant: false
is: SBO:0000297
is encoded by: hsa:4905
has part: Q6IBB3
type: Species
has part: A0PJH2
has part: O75964
is encoded by: hsa:516

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
type: Species
is: HMDB06841
boundary condition: false
is: CHEBI:16608
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2118
reactant: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110034#

metaR r1381
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110034#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
product: MODEL1310110034#

metaM bildglcur r
constant: false
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: CHEBI:58471
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR AKR1C1
reversible: false
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.1.20
modifier: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ
is: SBO:0000176

metaM leuktrE4 e
has only substance units: false
constant: false
is: HMDB02200
type: Species
name: leukotriene E4(1-)
initial amount: NaN
is: CHEBI:57462
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_7f81136c_e998_4d70_9aa3_68e52d7f8f67
is: SBO:0000252
is encoded by: hsa:2348
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: FOLR1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e52b68de_4056_44d1_94c6_300506122b5c
is: SBO:0000252
initial concentration: NaN
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR RE3326M
type: Reaction
reactant: MODEL1310110034#
name: RE3326
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#

metaM f6p c
type: Species
is: http://identifiers.org/pubchem.compound/3385
has only substance units: false
initial amount: NaN
is: CHEBI:57579
is: HMDB00124
initial concentration: 1.0
constant: false
is: C00085
is: SBO:0000247
boundary condition: false
name: D-Fructose 6-phosphate

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_86d4f393_789f_4ff0_9e37_595dda0166b2
name: DGAT2
is: Q96PD7
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:84649
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR GARFT
product: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.2
name: phosphoribosylglycinamide formyltransferase
is: SBO:0000176
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_55233f49_bfa0_498a_9c46_a3ce80cfa4ce
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA177072
is: SBO:0000252
has only substance units: false
name: _AA177072_1_c

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false
is: CHEBI:17168
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
boundary condition: false
initial amount: NaN
is: HMDB01170
is: SBO:0000247
type: Species
constant: false

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR ACGAMPM
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction
is: SBO:0000176
name: phosphoacetylglucosamine mutase
fast: false

metaR S6TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reversible: true

metaR RE1709C
reversible: true
name: RE1709
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaR RE0926E
name: RE0926
product: MODEL1310110034#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110034#

metaM gq1c hs g
has only substance units: false
boundary condition: false
constant: false
name: GQ1c
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28058
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_f7340cff_addb_4382_89de_16fa7711d16d
constant: false
name: NUDT12
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:83594
is: Q9BQG2
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1951
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000185

metaR TMDPK
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110034#
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.6.2
fast: false

metaM glx m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:36655
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
is: SBO:0000247
type: Species

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaM tdcoa x
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: C02593
boundary condition: false

metaM pan4p m
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_0d9aaab1_6cf2_4d1a_8b2d_67a069298725
name: NDUFB7
is encoded by: hsa:4713
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: P17568
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1952
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
modifier: MODEL1310110034#
type: Reaction
reversible: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM sucsal m
boundary condition: false
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
initial concentration: 1.0
is: HMDB01259
is: CHEBI:57706
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR r0330
reversible: false
reactant: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_fa998185_e57a_4927_a83e_e1223cbb40ca
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6489
initial concentration: NaN
name: ST8SIA1
is: Q92185
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a18959b6_de5b_4e9b_be27_7b6793d6d66b
initial concentration: NaN
name: SCD
is: O00767
boundary condition: true
is encoded by: hsa:6319
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_811c1a22_44e2_43cd_b0f1_9363a3587cd7
is encoded by: hsa:5277
name: PIGA
is: P37287
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR SUBERCACT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM tetdec2crn e
constant: false
initial concentration: 1.0
is: HMDB05066
is: SBO:0000247
name: tetradecadienoyl carnitine
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H37NO4 CHARGE: 0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_9faced4a_c29f_47aa_92d7_e083457cca76
is encoded by: hsa:3420
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: IDH3B
is: O43837
constant: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r0119
reactant: MODEL1310110034#
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110034#
fast: false
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000

metaR r2002
reactant: MODEL1310110034#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110034#
is: SBO:0000185
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110034#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR ACOAD8m
is version of: http://identifiers.org/ec-code/1.3.99.10
fast: false
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: false
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial

metaM c101crn e
has only substance units: false
constant: false
initial amount: NaN
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
name: decenoyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_78ca95bb_1c8c_4230_bc63_e48605618fc5
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q96QG2
name: SLC8A3
is encoded by: hsa:6547

metaR RE1519M
modifier: MODEL1310110034#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110034#

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000304
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176

metaM leuktrE4 c
is: HMDB02200
boundary condition: false
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: leukotriene E4(1-)

http://identifiers.org/biomodels.db/MODEL1310110034#_fb01ed92_ef64_42e0_9eb1_afd42a8bad10
has only substance units: false
name: ME3
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10873
boundary condition: true
initial amount: NaN
is: Q6TCH8
constant: false

metaR C51CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_7813906f_e730_49c3_891e_bc5eda0e84a7
name: AOX1
has only substance units: false
initial amount: NaN
is: Q06278
boundary condition: true
is: SBO:0000252
is encoded by: hsa:316
initial concentration: NaN
type: Species
constant: false

metaR RE3520E
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176
name: RE3520
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5323b55f_4f2b_45ad_8aee_56809bfb567f
type: Species
boundary condition: true
has only substance units: false
is: P49914
name: MTHFS
is encoded by: hsa:10588
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR ALDD2xm
modifier: MODEL1310110034#
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
product: MODEL1310110034#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134

metaR EX c16dc
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_7a5c4284_6090_4a95_b0c5_d115bec4d20d
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q10472
name: GALNT1
has only substance units: false
is encoded by: hsa:2589
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_c8bdbb2d_aa8c_4895_aaec_0dcc127c872d
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ALDH9A1
is: P49189
is: SBO:0000252
is encoded by: hsa:223
has only substance units: false
type: Species

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_44c74f9d_3f67_4868_9441_f3dee57b7d27
boundary condition: true
has only substance units: false
is encoded by: hsa:84532
is: SBO:0000252
is: Q9NUB1
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ACSS1

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR CHATn
kinetic law: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
type: Reaction
is: SBO:0000176
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

metaM glygn5 e
is: CHEBI:17754
is: C00116
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
boundary condition: false
notes: FORMULA: C12H21O11X CHARGE: 0
is: HMDB00131
constant: false
initial amount: NaN

metaR r1090
fast: false
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110034#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110034#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is described by: ECO:0000000

metaM nicrnt c
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: CHEBI:57502
is: C01185
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: Nicotinate D-ribonucleotide
has only substance units: false
is: HMDB01132
initial concentration: 1.0

metaR BILDGLCURtr
name: glucuronidated compound transport
reversible: true
fast: false
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction

metaM c101crn c
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: decenoyl carnitine
is: HMDB13205
constant: false
has only substance units: false
initial amount: NaN

metaR ACt2m
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
is: SBO:0000185
product: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_b8fc631a_3e73_4043_aeb7_d4410858903f
constant: false
initial amount: NaN
name: GPX5
initial concentration: NaN
is encoded by: hsa:2880
type: Species
has only substance units: false
is: O75715
boundary condition: true
is: SBO:0000252

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_6f312b10_7a0a_4915_bff0_1f0b52128c62
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI222095_1_m
is encoded by: hsa:AI222095

http://identifiers.org/biomodels.db/MODEL1310110034#_b094cdc4_bebd_4c12_bfab_7116c671a71c
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:226
has only substance units: false
name: ALDOA

metaR PHEMEtm
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
reactant: MODEL1310110034#
name: Heme transport to cytosol
fast: false

metaM ump r
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
name: UMP
is: SBO:0000247
is: CHEBI:57865
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00288
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_25feac9a_bbd4_4ca3_83e7_bb271ed38719
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5198
initial concentration: NaN
is: Q6P4B4
type: Species
constant: false
name: PFAS

metaR r0706
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.3
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_43b3d36c_60b2_45a5_9471_e7f7a3207a59
initial concentration: NaN
has only substance units: false
is: Q8NFW8
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55907
constant: false
name: CMAS
type: Species

metaR DNDPt27m
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110034#
is: SBO:0000185
type: Reaction
name: dCDP transport via dTDP antiport
product: MODEL1310110034#
is described by: ECO:0000269

metaR r2329
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110034#

metaR CHOLATEt
name: cholate transport via bicarbonate countertransport
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110034#
modifier: MODEL1310110034#

metaM hs deg15 l
initial amount: NaN
boundary condition: false
is: CHEBI:16126
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
name: heparan sulfate, degradation product 15

metaM ksi deg14 l
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:12936
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 14
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_574af26c_f62e_499f_8e6c_9468c8aa6ea1
is: Q9NP59
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SLC40A1
is encoded by: hsa:30061
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_d9f45fdf_3070_4960_96a4_caf2da0d7a08
name: SDS
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10993
boundary condition: true
is: SBO:0000252
is: P20132
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_87aad412_57e4_4aa0_989f_66165481fc9d
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: H7C5B8
boundary condition: true
is encoded by: hsa:4708
name: NDUFB2

metaR THRGLNexR
product: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110034#

metaR PI4PP
reversible: false
type: Reaction
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
name: phosphatidylinositol-4-phosphate 4-phosphatase
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
kinetic law: MODEL1310110034#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110034#_c566839c_2709_4175_8a6a_985188a88d92
has only substance units: false
boundary condition: true
name: PEMT
constant: false
is encoded by: hsa:10400
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_2e80fb2c_a2a0_4774_8e4e_d6c9c7f0ec11
initial amount: NaN
name: XDH
boundary condition: true
has only substance units: false
is: P47989
is encoded by: hsa:7498
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_46919f10_7110_46c2_b28f_2b82398923ba
boundary condition: true
has only substance units: false
is encoded by: hsa:4669
initial amount: NaN
constant: false
is: SBO:0000252
name: NAGLU
initial concentration: NaN
is: P54802
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_7d7ff509_bbbe_4331_a5b5_9c069c1d7b39
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:9374
has only substance units: false
is: Q9UMR5
type: Species
name: PPT2
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_7bf5d797_c8bd_425c_b3f5_7a42c88e2971
is: O43175
type: Species
is: SBO:0000252
name: PHGDH
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:26227

http://identifiers.org/biomodels.db/MODEL1310110034#_f2d4789f_b4aa_4ea9_99fb_0fb043a30eb8
type: Species
boundary condition: true
is encoded by: hsa:2585
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q01415
name: GALK2

http://identifiers.org/biomodels.db/MODEL1310110034#_756ff323_6094_4f29_bb69_84737c2da3c6
is: P51688
is encoded by: hsa:6448
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SGSH
boundary condition: true

metaR RE1709N
kinetic law: MODEL1310110034#
name: RE1709
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.96

http://identifiers.org/biomodels.db/MODEL1310110034#_3a611254_691b_4c4e_aba7_8d2be95a5b26
initial amount: NaN
initial concentration: NaN
name: PLCB4
is: SBO:0000252
has only substance units: false
is: Q15147
type: Species
constant: false
boundary condition: true
is encoded by: hsa:5332

metaR CYOOm3
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
is: SBO:0000185
name: cytochrome c oxidase, mitochondrial Complex IV
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR APOCFm
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#
type: Reaction
fast: false
reactant: MODEL1310110034#
name: Apocarboxylase formation, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110034#

metaR LDH D
kinetic law: MODEL1310110034#
name: D-lactate dehydrogenase
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110034#_4ad2c690_f83a_4176_ae8c_1d948fbdc960
initial amount: NaN
name: DGKA
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1606
type: Species
is: P23743
constant: false

metaM mn l
initial amount: NaN
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
is: HMDB06535
type: Species
is: SBO:0000247
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
constant: false

metaR r1156
is described by: ECO:0000000
reactant: MODEL1310110034#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: true
fast: false

metaM retinal cis 13 r
is: SBO:0000247
is: CHEBI:45487
name: 13-cis-retinal
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
is: HMDB06220
type: Species

metaM ksi deg29 l
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 29
is: HMDB00143
type: Species
initial concentration: 1.0
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
has only substance units: false
initial amount: NaN

metaR DNDPt15m
reversible: false
fast: false
is: SBO:0000185
name: dUDP transport via dGDP antiport
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM ga2 hs g
boundary condition: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
is: CHEBI:465284
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: GA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_9e3848fc_ebfc_4c22_855c_cee5baf4a3cc
initial concentration: NaN
name: IDS
type: Species
is: B4DGD7
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3423

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_ced6c13d_8fde_4028_a082_c0af105900cd
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2990
is: P08236
has only substance units: false
boundary condition: true
is: SBO:0000252
name: GUSB
type: Species

metaM acnamp c
name: N-Acetylneuraminate 9-phosphate
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:27438
is: HMDB06268
initial concentration: 1.0

metaR DURAD
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110034#
name: dihydrouracil dehydrogenase (NADP)
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
kinetic law: MODEL1310110034#

metaM 34dhoxmand m
constant: false
initial concentration: 1.0
has only substance units: false
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
is: SBO:0000247
is: HMDB01866
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_76d4d1bf_2b4a_44df_9cb4_bfb8d10f38db
is: Q546H9
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:7915
name: ALDH5A1
is: SBO:0000252
boundary condition: true

metaR LYSOXp
is: SBO:0000176
fast: false
name: L-lysine oxidase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is described by: ECO:0000000

metaM ump n
boundary condition: false
initial amount: NaN
is: HMDB00288
name: UMP(2-)
type: Species
has only substance units: false
is: CHEBI:57865
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110034#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#

metaR SARCStex
fast: false
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
name: Sarcosine transport (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110034#_9cf8e04e_185e_4403_b35a_e8aa1f7f423e
boundary condition: true
name: ALDOB
is: P05062
has only substance units: false
is: SBO:0000252
is encoded by: hsa:229
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_cb08b23a_b9d4_4553_8ecd_8795a96dc238
constant: false
has only substance units: false
name: _AV727634_1_c
is: SBO:0000252
is encoded by: hsa:AV727634
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR RE1448N
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
kinetic law: MODEL1310110034#
name: RE1448
fast: false
is: SBO:0000176

metaM sucr e
initial amount: NaN
is: HMDB00258
is: CHEBI:17992
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: C00089
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
name: Sucrose
type: Species
boundary condition: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM retinal cis 9 c
type: Species
name: all-trans-retinal
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17898
initial concentration: 1.0
initial amount: NaN
is: HMDB01358
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaR ACACtx
type: Reaction
product: MODEL1310110034#
fast: false
name: acetoacetate intracellular transport unknown mechanism
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true

metaR MCPST
modifier: MODEL1310110034#
name: 3-mercaptopyruvate sulfurtransferase
reversible: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
is described by: ECO:0000134
is: SBO:0000176

metaR BACCLm
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110034#
fast: false
is described by: ECO:0000254
reactant: MODEL1310110034#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110034#
reversible: false
type: Reaction
product: MODEL1310110034#

metaR GGLUCT
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
is: SBO:0000185
name: gamma-glutamylcyclotransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.4
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0905e30b_e3bf_4ab1_b66c_ad694ec5c443
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4697
initial amount: NaN
is: O00483
type: Species
name: NDUFA4
constant: false

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57597
has only substance units: false
name: Glycerol 3-phosphate
type: Species
initial concentration: 1.0
is: C00093
initial amount: NaN

metaR r1827
is: SBO:0000185
fast: false
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0741
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is: SBO:0000176
reactant: MODEL1310110034#
fast: false
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

metaM chsterol c
constant: false
is: CHEBI:16113
initial amount: NaN
is: HMDB00067
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol

metaM gluside hs r
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
has only substance units: false
initial amount: NaN
is: CHEBI:18368
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR LPS3
reversible: false
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
reactant: MODEL1310110034#
is described by: ECO:0000000
name: lipase
kinetic law: MODEL1310110034#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.23

metaM udpgal g
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: CHEBI:58439
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00302

http://identifiers.org/biomodels.db/MODEL1310110034#_b5937bf7_a055_40ea_b476_9783d54134d7
initial amount: NaN
type: Species
is encoded by: hsa:55577
boundary condition: true
initial concentration: NaN
name: NAGK
is: Q9UJ70
constant: false
is: SBO:0000252
has only substance units: false

metaM gmp e
initial concentration: 1.0
is: HMDB01397
initial amount: NaN
name: GMP(3-)
is: SBO:0000247
is: CHEBI:58115
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR GQ1BALPHAte
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
fast: false
name: gq1balpha hs transport
type: Reaction
is: SBO:0000185

metaM dutp n
is: CHEBI:17625
is: HMDB01191
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: dUTP
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false

metaM 34dhmald m
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
is: C05577
constant: false
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
has only substance units: false
is: HMDB06242
is: SBO:0000247
initial amount: NaN

metaM b2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
type: Species
constant: false
boundary condition: false
is: CHEBI:57332
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02009
is: SBO:0000247

metaR r2338
kinetic law: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_60f1dea5_0871_4732_8ba9_f0aaf4a15643
is encoded by: hsa:6567
type: Species
is: P36021
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC16A2
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_e5c10670_094c_4498_b9ba_9fdbc0300643
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PTDSS1
is: SBO:0000252
is encoded by: hsa:9791
initial amount: NaN
constant: false
is: P48651

http://identifiers.org/biomodels.db/MODEL1310110034#_0726625f_a1cc_4772_ae5d_a0e2d2f9e73a
type: Species
is: P00441
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6647
name: SOD1
has only substance units: false
initial amount: NaN
boundary condition: true

metaM datp c
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
is: HMDB01532
constant: false
boundary condition: false
type: Species
name: dATP
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00131

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
fast: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
modifier: MODEL1310110034#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_d30c2ead_a7da_4899_8a7d_f098c27a907e
initial amount: NaN
name: SLC1A1
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:6505
initial concentration: NaN
is: P43005
constant: false
has only substance units: false

metaM pail5p hs c
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
is: CHEBI:57795
type: Species

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR GLYtm
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
reversible: true
fast: false
name: glycine passive transport to mitochondria
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110034#

metaR GQ1BALPHAtg
name: gq1balpha hs intracellular transport
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110034#
reversible: true

metaR HSPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
product: MODEL1310110034#
reversible: false
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110034#

metaR r0743
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110034#
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35

metaR PROSTGI2t
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaM sebacid x
is: C08277
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00792
name: sebacicacid
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_85333982_efc0_42ec_b716_67d3a8f51dd5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:226
type: Species
constant: false
name: ALDOA
is: P04075
initial amount: NaN
boundary condition: true
has only substance units: false

metaR SADT
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
reversible: false
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false

metaM gmp c
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58115
is: HMDB01397
initial amount: NaN
is: C00144
name: GMP

metaM mercppyr c
is: CHEBI:57678
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 3-mercaptopyruvate
constant: false
type: Species
is: HMDB01368
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_8270636d_ca16_45a8_92dd_082ff9846ff4
initial concentration: NaN
boundary condition: true
has only substance units: false
name: LDHAL6A
is encoded by: hsa:160287
is: Q6ZMR3
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_66cc80e8_f4e6_42c9_aa0d_84e234ca4289
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: O95299
initial amount: NaN
is encoded by: hsa:4705
boundary condition: true
name: NDUFA10
initial concentration: NaN

metaR GTHRDt
name: Glutathione transport into mitochondria
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true
is: SBO:0000185
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f63d523a_5012_4417_9994_48dd57a303c0
is: P10696
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ALPPL2
is encoded by: hsa:251
initial amount: NaN

metaR r0899
fast: false
reversible: true
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

metaR r0744
kinetic law: MODEL1310110034#
type: Reaction
reversible: false
reactant: MODEL1310110034#
product: MODEL1310110034#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaM HC01409 m
boundary condition: false
type: Species
name: Hexanoyl-CoA
is: CHEBI:27540
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
initial concentration: 1.0

metaM 42A3HP24DB c
is: HMDB04083
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
boundary condition: false
initial concentration: 1.0
is: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7956
constant: false

metaR 5HLTDL
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110034#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false

metaM pectindchac e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2559H3549O2539 CHARGE: -1
name: pectin-deoxycholic acid complex
is: HMDB03402
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaM hs deg21 l
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:16126

metaR r2101
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110034#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110034#_05483198_4f27_4fbd_940d_e4d9acebdaa1
initial amount: NaN
name: TALDO1
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6888
is: P37837

metaM asp D c
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB06483
is: CHEBI:29990
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_fa030e8c_9e2b_45c6_a8f4_86babee41910
is: SBO:0000252
initial amount: NaN
name: CA2
type: Species
boundary condition: true
has only substance units: false
is: P00918
initial concentration: NaN
is encoded by: hsa:760
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e2114c3e_2c16_4f0d_b533_bad33a86561c
type: Species
constant: false
name: COX7C
initial amount: NaN
initial concentration: NaN
is: P15954
is: SBO:0000252
is encoded by: hsa:1350
has only substance units: false
boundary condition: true

metaR r2333
reversible: true
type: Reaction
reactant: MODEL1310110034#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_b341e65d_93f6_415b_bab3_223a7007ce98
boundary condition: true
is encoded by: hsa:8372
name: HYAL3
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: O43820
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_589612b0_1b43_43fb_a954_4e7c77585333
type: Species
is encoded by: hsa:AA177072
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: _AA177072_1_x
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_2e20a9b4_08fd_4d1e_bb62_3c41589c8c77
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:H17063
name: _H17063_1_m
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaR RE0830C
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: RE0830
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true
fast: false

metaR FAOXC12C12OHm
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR UGALNACtg
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
product: MODEL1310110034#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110034#
name: UDP-GalNAc Golgi transport via CMP antiport

metaM udpgal c
initial amount: NaN
name: UDP-D-galactose(2-)
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
is: HMDB00302
is: CHEBI:58439
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b43e6a93_d8cc_4d0a_b77c_97db8ce1a7f5
is: P15309
name: ACPP
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:55
initial concentration: NaN

metaR r2102
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is: SBO:0000176
fast: false
type: Reaction
name: RE3347
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true

metaR RE1531M
name: RE1531
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110034#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_aee96025_028f_493c_8fd2_4cfd65be04d7
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q96RQ3
is encoded by: hsa:56922
constant: false
has only substance units: false
name: MCCC1

metaM fe3 c
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: Fe3+
initial amount: NaN
boundary condition: false
constant: false

metaM glyphe c
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Glycylphenylalanine
initial amount: NaN
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/97415
initial concentration: 1.0

metaR r2334
reactant: MODEL1310110034#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
product: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_eda97907_e027_4c35_9dc4_ff874fa1776c
type: Species
is: SBO:0000252
is encoded by: hsa:9551
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: F8W7V3
initial amount: NaN
name: ATP5J2

http://identifiers.org/biomodels.db/MODEL1310110034#_1ad83b32_b585_484d_954b_3ee1840f06fb
initial amount: NaN
initial concentration: NaN
name: ABAT
is encoded by: hsa:18
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_dc499f34_8ac7_4768_af8b_2d4df9a6f678
has only substance units: false
is encoded by: hsa:5150
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: PDE7A
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_96bfd105_37c5_44fa_94c0_a200b29d00c3
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: _AA629629_1_m
initial amount: NaN
is encoded by: hsa:AA629629

http://identifiers.org/biomodels.db/MODEL1310110034#_bfb91921_256d_498b_89c9_914d4133b783
initial amount: NaN
has only substance units: false
is encoded by: hsa:349565
name: NMNAT3
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q96T66

metaM C05280 m
type: Species
constant: false
has only substance units: false
is: CHEBI:28002
boundary condition: false
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial amount: NaN
is: HMDB03952
is: SBO:0000247

metaR NAGA2ly
reversible: false
is described by: ECO:0000000
name: N-acetylgalactosaminidase, alpha-
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is version of: http://identifiers.org/ec-code/3.2.1.49
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2d53a7a2_5759_4726_8f2b_9716585cf299
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:19
name: ABCA1
is: O95477
constant: false
type: Species
boundary condition: true

metaR r0747
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#

metaM ksi deg32 l
initial amount: NaN
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 32
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C82H135N5O67S2 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110034#_de7851bd_eee4_47c4_a1a5_698099f6229b
is: SBO:0000297
type: Species
is encoded by: hsa:518
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
has part: P48201
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM asp D e
has only substance units: false
is: CHEBI:29990
is: HMDB06483
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
name: D-aspartate(1-)
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_2082fd98_fb45_497e_bdc4_281ca9969c5f
is encoded by: hsa:3704
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9BY32
boundary condition: true
has only substance units: false
name: ITPA
constant: false

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:58115
is: HMDB01397
name: GMP(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f8379a17_9011_42ff_ad81_75507d122be2
is: SBO:0000252
type: Species
name: UCK2
boundary condition: true
constant: false
initial concentration: NaN
is: Q9BZX2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7371

metaR r2335
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is: SBO:0000185
product: MODEL1310110034#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2100
reactant: MODEL1310110034#
type: Reaction
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110034#
reversible: true

metaM acac x
has only substance units: false
initial amount: NaN
boundary condition: false
name: acetoacetate
initial concentration: 1.0
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
is: HMDB00060
type: Species
is: SBO:0000247

metaR MTHGXLt
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
name: Methylglyoxal transport (cytosol to extracellular)
reactant: MODEL1310110034#
product: MODEL1310110034#

metaR SUCCt4 2
name: succinate transport via sodium symport
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_9663428f_78d1_462b_ad62_2b81b419f9db
initial amount: NaN
initial concentration: NaN
constant: false
is: O14734
is encoded by: hsa:10005
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACOT8
type: Species

metaR GLYt2r
is described by: ECO:0000304
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_1888d6e2_1b67_4df8_9245_39b496d33dbc
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7371
is: Q9BZX2
name: UCK2

metaR OROTGLUt
fast: false
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000134
name: OROTGLUt
reversible: true

metaR LPS2
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110034#
name: lipase
is: SBO:0000176
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/3.1.1.34
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction

metaM 4mlacac c
initial amount: NaN
constant: false
name: 4-maleylacetoacetate
has only substance units: false
is: HMDB02052
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial concentration: 1.0
is: CHEBI:17105
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_107f17fb_c2c3_4a94_be03_6c5cc6c3db01
boundary condition: true
type: Species
name: PLCG2
is: P16885
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5336

metaM ksii core2 deg4 l
name: keratan sulfate II (core 2-linked), degradation product 4
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1
is: HMDB00812
type: Species
is: CHEBI:16953
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_ab54bd1c_3c33_4054_ad9f_530e473005f5
is: P00439
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5053
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PAH
type: Species

metaR METS
name: methionine synthase
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
modifier: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.13

http://identifiers.org/biomodels.db/MODEL1310110034#_ffa148dd_8fbb_40c2_b021_a25a8e1f5e1c
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:22305
type: Species
name: _22305_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR CYSGLTH
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
name: Glutathione:cystine oxidoreductase
is: SBO:0000176
type: Reaction

metaM thyox L e
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: L-thyroxine
boundary condition: false
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
is: CHEBI:18332

metaR r2105
type: Reaction
reversible: true
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110034#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110034#
fast: false
is: SBO:0000185

metaM andrstandn r
is: HMDB00899
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
name: 5alpha-androstane-3,17-dione
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_019ba679_f59d_4119_9b8a_3f1f2bb5acd2
is: Q92959
name: SLCO2A1
is encoded by: hsa:6578
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR r0892
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.2.27
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
reversible: true

metaR SCP22x
is described by: ECO:0000000
name: Sterol carrier protein 2
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
reversible: true
fast: false
product: MODEL1310110034#
is: SBO:0000185

metaR FUMm
is described by: ECO:0000134
modifier: MODEL1310110034#
name: fumarase, mitochondrial
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
fast: false
is: SBO:0000176
reactant: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2
reversible: true

metaR HAS2
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is: SBO:0000185
name: hyaluronan synthase

metaM chsterol l
type: Species
has only substance units: false
is: CHEBI:16113
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
name: cholesterol
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR ARACHDt2
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
name: fatty acid transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
reversible: true

metaR r2106
modifier: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110034#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110034#
type: Reaction
reversible: true

metaR SIAASE4ly
modifier: MODEL1310110034#
name: sialidase, lysosomal
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR PMTCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
name: fatty acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_36fa8b41_a9bc_4f90_8687_480dd38ef546
name: _AI345944_1_m
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI345944
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r2443
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false

metaR RE0830N
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction

metaR GLCURtly
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000269
name: glucuronate transport into lysososme
type: Reaction
modifier: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaM bildglcur c
boundary condition: false
is: HMDB03325
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58471
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR MAL Ltx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Transport reaction for malate
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_69cfcf86_5636_4d82_aa2c_34819b4d0208
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2523
name: FUT1
constant: false
is: SBO:0000252
is: Q6IZA2
type: Species
has only substance units: false
initial amount: NaN

metaR PE HSter
kinetic law: MODEL1310110034#
is: SBO:0000185
name: phosphatidylethanolamine scramblase
reversible: true
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaR RE1233C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176
reversible: true
reactant: MODEL1310110034#
type: Reaction
fast: false
name: RE1233
is described by: ECO:0000000
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110034#

metaM dmpp x
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57623
name: prenyl diphosphate(3-)
has only substance units: false
initial amount: NaN
constant: false

metaR BILIRUBt2
name: bilirubin transport via bicarbonate countertransport
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaR r2331
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM ttdca e
is: HMDB00806
has only substance units: false
is: CHEBI:30807
initial amount: NaN
is: C06424
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: tetradecanoate (n-C14:0)

http://identifiers.org/biomodels.db/MODEL1310110034#_71e9f6ba_268f_4ed5_90f1_bc25551dad5e
initial amount: NaN
is: SBO:0000252
name: DYLX2
boundary condition: true
has only substance units: false
type: Species
is: F5H123
constant: false
is encoded by: hsa:9856
initial concentration: NaN

metaM retinal cis 9 r
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial amount: NaN
name: all-trans-retinal
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17898
is: HMDB01358
type: Species

metaR r2103
kinetic law: MODEL1310110034#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true

metaR CMPSASn
reactant: MODEL1310110034#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
product: MODEL1310110034#
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: CMP sialic acid synthase, nuclear
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176

metaR MCLOR
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 3-Mercaptolactate:NAD+ oxidoreductase
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

metaR r0596
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#

metaM glyphe e
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Glycylphenylalanine
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
has only substance units: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b95bf59a_55fd_4389_8fab_43eab02a4d8a
name: NANS
type: Species
is encoded by: hsa:54187
boundary condition: true
initial concentration: NaN
constant: false
is: Q9NR45
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_08417700_06b9_4bc4_bb1a_62781f48565b
constant: false
is: SBO:0000252
initial amount: NaN
is: A7E2E5
type: Species
is encoded by: hsa:5140
name: PDE3B
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_934494d8_eea5_4b39_813a_80ff26a70a10
boundary condition: true
name: _AI373818_1_m
initial amount: NaN
type: Species
is encoded by: hsa:AI373818
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaM gluside hs g
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
is: SBO:0000247
is: CHEBI:18368
type: Species
initial concentration: 1.0
has only substance units: false
name: D-glucosyl-N-acylsphingosine

metaR r2332
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR DM T antigen g
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaM fe3 e
name: Fe3+
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB12943
initial concentration: 1.0
is: CHEBI:29034
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e2096d5f_17d3_4085_a996_4963e1ecf4d6
is encoded by: hsa:10846
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: Q9Y233
name: PDE10A
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_33e1dd0c_5ddd_4661_a672_29d1ea6a3c9d
is encoded by: hsa:AI191472
name: _AI191472_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false

metaM bildglcur e
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:58471
type: Species
has only substance units: false
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin

metaR r2104
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_9fd1c552_2583_4091_9489_d8f95cc898ea
name: ALDH2
initial amount: NaN
is: P05091
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:217
boundary condition: true
is: SBO:0000252

metaR L LACDcm
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is described by: ECO:0000000
reactant: MODEL1310110034#
reversible: false
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_6812e2f4_5283_4501_9190_7a6cc995f892
boundary condition: true
is: B2RD24
name: MTHFD1L
initial concentration: NaN
is encoded by: hsa:25902
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR r2109
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: true
type: Reaction

metaM pcrn m
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738
constant: false
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: propionyl-carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_82bd1d0d_c62c_4260_93f9_b703c690e76c
initial amount: NaN
is: P21399
name: ACO1
constant: false
is: SBO:0000252
is encoded by: hsa:48
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_3f554f2d_4f55_4d60_af56_66ad3b17aad3
is: SBO:0000252
constant: false
boundary condition: true
name: _PRO1933_1_m
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:PRO1933
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_8b681312_f3c8_43f2_8094_e880cf7b61e2
is: SBO:0000252
type: Species
constant: false
is: O95427
initial amount: NaN
has only substance units: false
boundary condition: true
name: PIGN
is encoded by: hsa:23556
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_1942dcbc_6f96_4ab1_be21_724326d7f227
is: SBO:0000252
is encoded by: hsa:3425
initial amount: NaN
name: IDUA
type: Species
has only substance units: false
constant: false
is: P35475
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_df264bc7_8e89_48bf_96b0_ad49d48b94da
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110034#_6dab07ad_9d8a_4832_9ac1_d56eb48195a6
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DGKZ
is encoded by: hsa:8525
is: SBO:0000252
is: B7Z6M3
type: Species

metaM xol7a r
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: SBO:0000247
is: CHEBI:1296
is: HMDB01496
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: 20-hydroxycholesterol
boundary condition: false

metaR UMPK7n
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000269
name: UMP kinase (dGTP),nuclear
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110034#

metaM acac m
initial amount: NaN
type: Species
is: HMDB00060
boundary condition: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: acetoacetate

http://identifiers.org/biomodels.db/MODEL1310110034#_d75761a1_975d_4424_aa21_ff290c228e30
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: _U37519_1_e
initial amount: NaN
is encoded by: hsa:U37519

metaM thbpt4acam c
boundary condition: false
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:15374
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_21d4cf21_2401_4d39_a5bb_ee4ceefca2c0
has part: Q96RQ3
has part: Q9HCC0
is: SBO:0000297
is encoded by: hsa:56922
has only substance units: false
name: MCCC1:MCCC2
initial amount: NaN
boundary condition: true
is encoded by: hsa:64087
initial concentration: NaN
constant: false
type: Species

metaR r0594
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110034#_e6fe1036_a547_418c_a976_4c2ffcf07b81
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5151
initial concentration: NaN
is: SBO:0000252
constant: false
name: PDE8A
boundary condition: true

metaM xoldioloneh c
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
is: CHEBI:2288
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB06887
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_db8dd836_8c50_4b7b_afc8_d5da63f786cf
initial amount: NaN
type: Species
is: P12235
is encoded by: hsa:291
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC25A4
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_313c2df3_9117_45a5_90f3_61e7f8775217
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC22A1
is: SBO:0000252
constant: false
is encoded by: hsa:6580
type: Species
boundary condition: true
is: O15245

metaR r2107
type: Reaction
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110034#

metaR r0321
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
modifier: MODEL1310110034#
fast: false
reversible: false
reactant: MODEL1310110034#

metaM chsterol e
is: CHEBI:16113
is: SBO:0000247
constant: false
name: cholesterol
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
type: Species

metaR r0591
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
fast: false
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9

metaM thyox L c
has only substance units: false
boundary condition: false
is: SBO:0000247
name: L-thyroxine
type: Species
initial concentration: 1.0
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
initial amount: NaN
constant: false
is: CHEBI:18332

http://identifiers.org/biomodels.db/MODEL1310110034#_7094d369_f557_4e9b_b5fd_a63bf5fd8ba8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4952
type: Species
initial amount: NaN
name: OCRL
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ccadd504_b695_49f9_ae42_06a2b0ec6263
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9UBM1
name: PEMT
constant: false
is encoded by: hsa:10400
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_7b6bb23e_ccfb_4f0d_a8ba_94293f982874
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q9Y666
is encoded by: hsa:10723
name: SLC12A7
has only substance units: false

metaM dutp m
initial amount: NaN
is: CHEBI:17625
is: HMDB01191
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: dUTP
constant: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_4616fde0_98a7_49d8_a3ac_c808d6db274f
name: ND3
has only substance units: false
constant: false
is encoded by: hsa:4537
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: P03897
initial amount: NaN

metaR r2108
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b35b7767_8d8d_4bd5_b252_716709b05802
has only substance units: false
is: P43353
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ALDH3B1
is encoded by: hsa:221
is: SBO:0000252

metaR C4STMO2r
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110034#
name: C-4 methyl sterol oxidase
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.72

http://identifiers.org/biomodels.db/MODEL1310110034#_e910bd82_ad26_4d9e_8fc3_78e05ac352a9
name: PYCR1
has only substance units: false
is: A6NFM2
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5831
constant: false

metaM gum e
constant: false
name: gums
type: Species
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR PPA
is described by: ECO:0000269
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_864d265f_b204_45c4_b441_e9f58abd5210
has only substance units: false
boundary condition: true
is: P00374
initial amount: NaN
initial concentration: NaN
constant: false
name: DHFR
is: SBO:0000252
type: Species
is encoded by: hsa:1719

metaM 3snpyr m
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02332
name: 3-Sulfinopyruvate
is: SBO:0000247
type: Species
is: CHEBI:1665
initial concentration: 1.0

metaR XYLtly
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
name: Xylose efflux from lysosome
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

metaM bglc e
initial amount: NaN
boundary condition: false
name: beta-glucans
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
is: HMDB00725

metaR SARCStm
reversible: false
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
name: Sarcosine transport (mitochondrial)
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaM Rtotal2coa c
has only substance units: false
initial concentration: 1.0
is: C00055
is: SBO:0000247
is: HMDB00095
is: CHEBI:60377
name: R total 2 coenzyme A
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
type: Species
is: C00288
is: CHEBI:17544
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00595
initial concentration: 1.0
constant: false
name: Bicarbonate

metaR r1298
name: Vesicular transport
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: false
product: MODEL1310110034#
fast: false

metaR CAATPS
modifier: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
type: Reaction
name: Ca ATPase
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.3.8
fast: false
product: MODEL1310110034#
is described by: ECO:0000269

metaM ivcrn c
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00688
name: isovaleryl carnitine
boundary condition: false
has only substance units: false
notes: FORMULA: C12H23NO4 CHARGE: 0
type: Species

metaM gua c
is: CHEBI:16235
boundary condition: false
is: HMDB00132
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00242
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a115f70d_840a_4476_8e41_97c3f6736187
is encoded by: hsa:954
boundary condition: true
initial amount: NaN
is: Q5SPY7
type: Species
name: ENTPD2
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_cb19e44a_e990_401d_b1f7_ad8d04f54a31
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:U37519
name: _U37519_1_m
is: SBO:0000252
initial concentration: NaN

metaM ha pre1 e
type: Species
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16126
boundary condition: false

metaR EHGLATm
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false
name: gamma-linolenate
is: SBO:0000247
type: Species
is: HMDB03073
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:32391

metaM hpyr c
initial amount: NaN
is: HMDB01352
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:17180
boundary condition: false
name: 3-hydroxypyruvate

metaR BILIRED
type: Reaction
fast: false
reactant: MODEL1310110034#
name: Nad(p)h biliverdin reductase
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
product: MODEL1310110034#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_6607e553_d6ec_4c9e_95da_0a6fb541e2ad
type: Species
is encoded by: hsa:9990
name: SLC12A6
is: SBO:0000252
is: Q9UHW9
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

metaR r1299
reversible: false
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
name: Vesicular transport
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c58efcca_54c0_4bb1_bdb9_1dbb336b88bb
has only substance units: false
is encoded by: hsa:51268
name: PIPOX
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9P0Z9
constant: false

metaM q10 e
is: HMDB01072
initial amount: NaN
is: CHEBI:46245
initial concentration: 1.0
name: ubiquinone-10
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
boundary condition: false

metaM citr L m
initial concentration: 1.0
is: HMDB00904
type: Species
is: CHEBI:16349
boundary condition: false
is: SBO:0000247
name: L-citrulline
constant: false
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_d7c1a883_07c2_466c_9805_d721cb1db596
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:9514
constant: false
initial concentration: NaN
name: GAL3ST1
boundary condition: true
is: SBO:0000252
is: Q99999

metaM 2mpdhl m
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM acac c
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
is: HMDB00060
name: acetoacetate
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_f0cbd7f3_6df8_4b5c_b1b9_3d6cc0863d65
initial concentration: NaN
boundary condition: true
is encoded by: hsa:549
initial amount: NaN
is: SBO:0000252
is: Q13825
type: Species
has only substance units: false
constant: false
name: AUH

http://identifiers.org/biomodels.db/MODEL1310110034#_ce3539e7_e730_43b5_9726_5eb88d5082e6
is: O43678
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4695
name: NDUFA2
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM 34dhpha c
is: SBO:0000247
has only substance units: false
is: CHEBI:17612
boundary condition: false
name: (3,4-dihydroxyphenyl)acetate
constant: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: HMDB01336
initial amount: NaN
type: Species
initial concentration: 1.0

metaM btn e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00030
has only substance units: false
type: Species
is: C00120
name: Biotin
initial concentration: 1.0
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false

metaM gua e
is: HMDB00132
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: guanine
has only substance units: false
constant: false
is: CHEBI:16235

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
initial concentration: 1.0
constant: false
name: cholesterol
has only substance units: false
type: Species
is: SBO:0000247

metaR SUCCOAPET
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_3ad755c1_de3c_4551_bcbf_0e994e60e4bb
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1375
has only substance units: false
name: CPT1B
constant: false
is: Q92523
initial concentration: NaN

metaR C16DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR ACNAMlt
modifier: MODEL1310110034#
is described by: ECO:0000269
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000185
type: Reaction
name: N-acetylneuraminate transport into lysososme
product: MODEL1310110034#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ

http://identifiers.org/biomodels.db/MODEL1310110034#_fc9c6568_2c3e_49ea_99c1_286778399f55
is: O14561
constant: false
name: NDUFAB1
boundary condition: true
is encoded by: hsa:4706
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR TCHOLAte
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: bile acid intracellular transport
reversible: true

metaM cit m
constant: false
is: SBO:0000247
name: Citrate
initial concentration: 1.0
is: CHEBI:16947
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: C00158
boundary condition: false
is: HMDB00094
has only substance units: false

metaM HC01405 m
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial concentration: 1.0
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28632
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_bae2ef5b_4f9a_4453_9cbc_e7c23a3a2020
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: P31350
is encoded by: hsa:6241
constant: false
initial concentration: NaN
name: RRM2
initial amount: NaN

metaM ksi deg33 l
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: SBO:0000247
name: keratan sulfate I, degradation product 33
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
constant: false
boundary condition: false
is: CHEBI:12936
type: Species

metaM q10 c
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
initial amount: NaN
is: HMDB01072
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110034#_be168d4f_c0cd_468b_a39c_27143b24d709
has part: Q9H3S5
constant: false
is encoded by: hsa:54965
is encoded by: hsa:93183
has part: Q8TBF5
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000297
name: PIGX:PIGM
has only substance units: false

metaR r1088
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is: SBO:0000185
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110034#_b6d1cdbf_1432_4ad1_9020_03aa7d387570
type: Species
is encoded by: hsa:29968
has only substance units: false
initial concentration: NaN
name: PSAT1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM acac e
has only substance units: false
boundary condition: false
is: HMDB00060
initial concentration: 1.0
is: CHEBI:13705
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
name: acetoacetate
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_087de69d_0e69_443d_a5c8_754ed84d9fe1
is encoded by: hsa:80864
has only substance units: false
initial amount: NaN
name: EGFL8
boundary condition: true
is: Q99944
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_d91fc31a_3f3e_4c45_8580_75347dbb72c4
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: COX6B2
has only substance units: false
is encoded by: hsa:125965
constant: false
is: Q6YFQ2

metaM HC00900 c
initial amount: NaN
is: CHEBI:30860
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Methylmalonate
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
constant: false

metaR 3HCO3 NAt
reversible: true
kinetic law: MODEL1310110034#
is described by: ECO:0000134
product: MODEL1310110034#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110034#
type: Reaction
name: 3HCO3_NAt

metaR SERDGLYexR
reversible: true
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_1b7dca7c_7059_4a4c_85a6_71b9ca067199
type: Species
boundary condition: true
is encoded by: hsa:3101
has only substance units: false
is: P52790
name: HK3
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM 3otdcoa x
is: CHEBI:28726
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB03935
has only substance units: false
type: Species

metaR C16DCe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR GPIMTer U
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
fast: false
reversible: false
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_bc17fe24_2a01_4d2c_bcea_937cfcd0f5f7
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51109
is: B4DDW0
type: Species
name: RDH11

metaM g3pc c
is: HMDB00086
type: Species
is: CHEBI:16870
constant: false
boundary condition: false
initial amount: NaN
name: sn-Glycero-3-phosphocholine
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_3c944e77_7428_4dc2_8b00_eaad09b5d445
is: SBO:0000252
is encoded by: hsa:1738
is: P09622
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: DLD
has only substance units: false

metaM dhap e
name: glycerone phosphate(2-)
is: HMDB01473
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_7ee50802_f78f_4aea_b1bc_fce90f6e2919
has only substance units: false
is: P08842
initial amount: NaN
name: STS
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:412
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_984e7af6_89fd_4d43_87d8_29b3c048892b
constant: false
is: SBO:0000252
is encoded by: hsa:1718
initial amount: NaN
boundary condition: true
name: DHCR24
type: Species
has only substance units: false
is: Q15392
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_10f2c704_08c7_4fe6_8494_c94729233dde
boundary condition: true
is encoded by: hsa:51227
is: SBO:0000297
has part: P57054
has only substance units: false
is encoded by: hsa:9091
type: Species
constant: false
is encoded by: hsa:5279
has part: B2RAU6
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
is encoded by: hsa:5277
initial amount: NaN

metaM glutcoa m
type: Species
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false
initial amount: NaN
initial concentration: 1.0
name: glutaryl-CoA(5-)
is: SBO:0000247
is: CHEBI:57378
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_5e9ac5f1_3f4f_42d5_a034_b38dd6d1d34d
is: B3KQP5
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: B3GALT4
is: SBO:0000252
is encoded by: hsa:8705
type: Species
constant: false

metaM maltpt e
name: maltopentaose
initial concentration: 1.0
boundary condition: false
is: C02052
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01296
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: HMDB00126
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Glycerol 3-phosphate
is: CHEBI:57597
type: Species
is: C00093

metaR 34DHPLACOX NADP
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
reactant: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is described by: ECO:0000269
fast: false
product: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction

metaM chsterol m
is: HMDB00067
type: Species
initial concentration: 1.0
name: cholesterol
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
fast: false
is: SBO:0000176
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_315b658e_400a_496c_8311_e95ef4ee1188
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: INPP4A
is encoded by: hsa:3631
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q96PE3

metaR r1989
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110034#

metaM hco3 c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00595
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: CHEBI:17544
name: Bicarbonate

metaM cs e deg3 l
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
boundary condition: false
type: Species
notes: FORMULA: C37H53NO44S4 CHARGE: -6
constant: false
has only substance units: false
is: CHEBI:15748
initial amount: NaN
is: HMDB00127

metaM dutp c
name: dUTP
is: C00460
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
type: Species
constant: false
is: HMDB01191
boundary condition: false
has only substance units: false
is: CHEBI:17625
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_7aa6c882_52a1_4aa8_a60e_c108702fb12d
initial amount: NaN
name: PANK1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q8TE04
is encoded by: hsa:53354
constant: false

metaM gluside hs c
initial amount: NaN
is: CHEBI:18368
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species

metaM ha pre1 l
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
type: Species
is: SBO:0000247

metaM trp L e
has only substance units: false
initial concentration: 1.0
name: L-tryptophan
constant: false
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
is: HMDB00929
is: SBO:0000247
type: Species
is: CHEBI:16828

metaM core2 g
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
is: SBO:0000247
initial amount: NaN
name: Core 2
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15876
initial concentration: 1.0

metaR FACOAL140i
modifier: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
product: MODEL1310110034#

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is: SBO:0000176
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000304

metaM dhap c
constant: false
type: Species
boundary condition: false
is: HMDB01473
initial concentration: 1.0
initial amount: NaN
is: C00111
name: Dihydroxyacetone phosphate
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642

metaM ivcrn e
type: Species
initial amount: NaN
notes: FORMULA: C12H23NO4 CHARGE: 0
is: HMDB00688
constant: false
initial concentration: 1.0
name: isovaleryl carnitine
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR HAtly
name: hyaluronan transport, extracellular to lysosome
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110034#

metaM 34dhmald c
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: 3,4-Dihydroxymandelaldehyde
type: Species
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ce2f49d0_321c_4164_b88e_46971089442b
is: P19440
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2678
type: Species
name: GGT1
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM nadh x
is: CHEBI:57945
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01487
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
constant: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
type: Species
initial concentration: 1.0

metaM lnlncg c
constant: false
initial amount: NaN
type: Species
name: gamma-linolenate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:32391
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

http://identifiers.org/biomodels.db/MODEL1310110034#_f13ed407_54c9_44c6_9131_e5f3dcc5965c
constant: false
type: Species
is encoded by: hsa:1347
name: COX7A2
is: H0UI06
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR HMGLx
type: Reaction
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
kinetic law: MODEL1310110034#
name: hydroxymethylglutaryl-CoA lyase
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: false

metaM trp L c
is: HMDB00929
is: SBO:0000247
initial amount: NaN
name: L-tryptophan
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
has only substance units: false
is: CHEBI:16828

metaR RDH3
reactant: MODEL1310110034#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
modifier: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
product: MODEL1310110034#
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADH)

http://identifiers.org/biomodels.db/MODEL1310110034#_14108e55_132d_4c65_b8aa_af8b4ddea81d
type: Species
constant: false
boundary condition: true
is encoded by: hsa:11343
is: B2ZGL7
has only substance units: false
initial concentration: NaN
name: MGLL
is: SBO:0000252
initial amount: NaN

metaM subeac x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00893
name: suberic acid
notes: FORMULA: C8H12O4 CHARGE: -2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e09837ca_f385_4e53_86cf_93d679178757
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6389
initial concentration: NaN
name: SDHA
is: P31040
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX tdcrn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM dd2coa c
is: HMDB03712
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_72a4e536_d490_4952_8601_34c97b810410
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:3032
is: SBO:0000252
constant: false
is: P55084
name: HADHB
initial concentration: NaN

metaR TPI
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: triose-phosphate isomerase
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110034#
reversible: true
product: MODEL1310110034#

metaM nadh r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
is: CHEBI:57945
boundary condition: false
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_65e1571f_4e51_413b_968c_89e1c1cbf5ff
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: _NM_013421_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:NM 013421

http://identifiers.org/biomodels.db/MODEL1310110034#_b5f2c86a_efba_4e44_8900_295d872dc84a
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4842
name: NOS1
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: B4DG68

metaM pcrn c
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
constant: false
name: propionyl-carnitine

metaM prostgi2 c
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57403
name: prostaglandin I2(1-)
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_b8e3b0f4_4440_449b_97aa_e307ce79b691
boundary condition: true
is: P43251
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:686
constant: false
name: BTD

metaM omhpal c
initial concentration: 1.0
is: HMDB06294
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
has only substance units: false
name: w-hydroxypalmiticacid
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e5e6b50d_5106_481d_a6f6_8175342205e7
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM q10 m
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:46245
has only substance units: false
is: HMDB01072
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
boundary condition: false
initial amount: NaN

metaR ALADGLNexR
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110034#
name: L-alanine/glutamine reversible exchange
reversible: true
reactant: MODEL1310110034#
fast: false

metaM 3spyr c
boundary condition: false
type: Species
is: HMDB04045
is: CHEBI:57940
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
name: 3-sulfonatopyruvate(2-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false

metaM citr L e
constant: false
name: citr_L[e]
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
boundary condition: false
is: CHEBI:16349
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
type: Species

metaM hs deg9 l
is: SBO:0000247
is: HMDB06355
constant: false
is: CHEBI:18268
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
boundary condition: false
name: heparan sulfate, degradation product 9
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_3ba3b8bf_99b9_4885_89d8_5789eaa7fdb7
boundary condition: true
is: SBO:0000252
name: ACAT1
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:38
is: P24752
has only substance units: false
initial amount: NaN

metaR RDH2
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
product: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
reactant: MODEL1310110034#
is: SBO:0000176
reversible: true

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM zym int2 r
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
name: zymosterol intermediate 2
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:52386

metaM gt3 hs g
has only substance units: false
is: SBO:0000247
is: CHEBI:28424
initial amount: NaN
constant: false
type: Species
name: GT3
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110034#_90400eed_1cc3_4b1b_86df_fa8906a35eaa
initial amount: NaN
is: P43004
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6506
initial concentration: NaN
name: SLC1A2
type: Species
boundary condition: true

metaR r0739
type: Reaction
reactant: MODEL1310110034#
reversible: true
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
is: SBO:0000176
fast: false
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:

metaM 20ahchsterol m
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: SBO:0000247
type: Species
constant: false
is: HMDB06283
initial amount: NaN
is: CHEBI:1296
boundary condition: false
has only substance units: false
name: 20-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110034#_afe0e425_89ca_4e5c_a09a_c0a833d6300c
is encoded by: hsa:515
is: P24539
is: SBO:0000252
name: ATP5F1
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaM pa hs c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:57739
boundary condition: false

metaR RDH1
type: Reaction
fast: false
name: retinol dehydrogenase (all-trans)
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is: SBO:0000176
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_d7836cf3_f2cd_4076_aa8a_55b98fc790d0
is: SBO:0000252
is encoded by: hsa:55825
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9BY49
initial amount: NaN
constant: false
name: PECR

metaM malthx e
is: C01936
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaR 4NPHSFte
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
reactant: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
name: xenobiotic transport
is: SBO:0000185
fast: false

metaM pser L c
is: HMDB01721
is: SBO:0000247
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
initial amount: NaN
name: O-Phospho-L-serine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15811
type: Species
constant: false

metaM prostgi2 e
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01335
has only substance units: false
is: CHEBI:57403
initial concentration: 1.0

metaM nadh m
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: HMDB01487
is: C00004
initial concentration: 1.0
boundary condition: false
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
type: Species
constant: false
initial amount: NaN

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is encoded by: hsa:114134
initial amount: NaN
constant: false
boundary condition: true
is: Q96QE2
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC2A13
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_248c4f77_f96d_411c_ba37_52e72be8be79
is: SBO:0000252
type: Species
boundary condition: true
is: Q14542
initial concentration: NaN
constant: false
has only substance units: false
name: SLC29A2
initial amount: NaN
is encoded by: hsa:3177

metaM biliverd c
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57991
initial amount: NaN
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: HMDB01008
name: biliverdin(2-)

metaM clpn hs c
name: cardiolipin
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:28494
initial amount: NaN
is: SBO:0000247
constant: false

metaR MI145PK
fast: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
type: Reaction
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.127
reversible: false
name: inositol-1,4,5-trisphosphate 3-kinase
reactant: MODEL1310110034#

metaM crm hs c
name: N-acylsphingosine
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
type: Species
is: CHEBI:52639
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_c88b59b2_7053_48a3_8651_2ca596cecf45
name: MVK
is: B2RDU6
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4598
has only substance units: false

metaM citr L c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
boundary condition: false
name: L-citrulline
type: Species
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

http://identifiers.org/biomodels.db/MODEL1310110034#_876c52ef_c953_4579_a781_9f66d049cb4f
is encoded by: hsa:5331
has only substance units: false
initial concentration: NaN
is: G5E960
initial amount: NaN
name: PLCB3
constant: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_21cce487_a3ca_4689_b48f_a9d56d99004c
initial amount: NaN
name: IDH3B
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3420
has only substance units: false
constant: false
is: SBO:0000252

metaR BILDGLCURt
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
fast: false
kinetic law: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_9d39b040_73bd_4c39_9754_eb73e1d3f6e7
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: PANK2
is encoded by: hsa:80025
initial amount: NaN
boundary condition: true
is: Q6P1K9

metaM trdox m
constant: false
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
is: SBO:0000247
is: CHEBI:18191
initial amount: NaN
type: Species
name: Oxidized thioredoxin
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_9591ef0d_0d45_4ac5_980f_42f17cf865b5
has part: Q6IB80
is encoded by: hsa:4713
is encoded by: hsa:4711
is encoded by: hsa:4731
has part: F8VQS7
has part: Q6IBC4
is encoded by: hsa:4539
has part: P28331
has part: P03897
is encoded by: hsa:4710
has part: O43674
has part: O95139
is encoded by: hsa:4538
is encoded by: hsa:4706
is encoded by: hsa:4536
is encoded by: hsa:4697
has part: Q7GXZ1
has part: Q7GXZ4
has part: Q13454
has part: Q9P0J0
is encoded by: hsa:7991
initial concentration: NaN
has part: B7Z792
has part: O95167
is encoded by: hsa:4716
is encoded by: hsa:4702
has part: O43678
is encoded by: hsa:4700
is encoded by: hsa:4720
has part: O75489
has part: Q6IBA0
is encoded by: hsa:4709
is encoded by: hsa:4729
has part: P56556
has part: Q6IBB5
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O00483
has part: H7C5B8
is encoded by: hsa:4537
is encoded by: hsa:4719
has part: O95168
is encoded by: hsa:4535
is encoded by: hsa:4696
has part: O43677
is encoded by: hsa:4726
is encoded by: hsa:4718
is encoded by: hsa:4695
has part: O14561
is encoded by: hsa:4705
is encoded by: hsa:4725
is encoded by: hsa:4541
is encoded by: hsa:4723
type: Species
has part: Q6FG42
has part: Q549M5
has part: Q7GXY9
has part: Q16718
has part: B1AM93
is encoded by: hsa:4715
constant: false
is encoded by: hsa:374291
is encoded by: hsa:4714
has part: Q16795
is encoded by: hsa:4712
has part: P03905
has part: E5KNH5
has part: O75251
is encoded by: hsa:4708
has part: O00217
is encoded by: hsa:4728
is: SBO:0000297
is encoded by: hsa:51079
is encoded by: hsa:4707
has part: P56181
has part: O95169
is encoded by: hsa:4540
has part: A8K761
is encoded by: hsa:55967
has part: P19404
has part: O43181

metaM btn c
is: HMDB00030
has only substance units: false
name: Biotin
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:3420

metaR DESAT20 1
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false
reversible: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
type: Reaction

metaM o2s x
is: CHEBI:18421
initial amount: NaN
name: superoxide
is: SBO:0000247
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial concentration: 1.0
is: HMDB02168
type: Species
has only substance units: false

metaR LACLt
kinetic law: MODEL1310110034#
fast: false
name: Lactate transport
is: SBO:0000185
reactant: MODEL1310110034#
reversible: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
product: MODEL1310110034#

metaR EX c81crn
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR RE1518M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
product: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1518
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
type: Reaction

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM hs deg18 l
boundary condition: false
is: HMDB01352
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 18
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial amount: NaN
is: CHEBI:17180
initial concentration: 1.0

metaM tetdece1coa c
name: tetradecenoylcoa
initial amount: NaN
is: SBO:0000247
is: HMDB05066
constant: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM datp n
initial amount: NaN
constant: false
is: C00131
name: dATP
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01532
is: CHEBI:61404

metaM gluala e
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 5-L-Glutamyl-L-alanine
is: C03740
is: HMDB06248
type: Species
has only substance units: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6503

http://identifiers.org/biomodels.db/MODEL1310110034#_dc71f937_ff11_4751_bd2b_1672144e407e
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:257068
constant: false
name: PLCXD2
is: Q0VAA5
has only substance units: false
is: SBO:0000252

metaR r1982
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
reactant: MODEL1310110034#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185

metaM ksii core4 deg2 l
name: keratan sulfate II (core 4-linked), degradation product 2
initial amount: NaN
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
constant: false
type: Species
is: HMDB00143

metaR SPH1Pte
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
type: Reaction

metaM 3hibutcoa m
is: SBO:0000247
is: HMDB01052
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
boundary condition: false
is: CHEBI:28259
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_1cc960d3_4a00_45b3_aefe_8757daa67987
is encoded by: hsa:622
boundary condition: true
name: BDH1
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_b45abd25_5ae9_43b1_996c_352d603cc721
type: Species
is: E7ET30
is encoded by: hsa:50808
initial amount: NaN
name: AK3
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r0731
fast: false
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110034#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR LEUPHELAT2tc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f6bd530b_2757_4233_8585_a09680247be1
initial amount: NaN
boundary condition: true
is encoded by: hsa:1036
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q16878
name: CDO1

http://identifiers.org/biomodels.db/MODEL1310110034#_162f7eb7_d1b3_4353_942f_f8e10049a35e
constant: false
is encoded by: hsa:2026
initial amount: NaN
name: ENO2
type: Species
is: SBO:0000252
has only substance units: false
is: P09104
initial concentration: NaN
boundary condition: true

metaR FAOXC4C4DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaM ddsmsterol r
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:27910
is: HMDB03896
name: 7-dehydrodesmosterol
initial concentration: 1.0
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
boundary condition: false
type: Species

metaR FAOXC12DCx
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM txa2 c
type: Species
has only substance units: false
initial concentration: 1.0
name: thromboxane A2(1-)
is: HMDB01452
initial amount: NaN
boundary condition: false
is: CHEBI:57445
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_c7384b0d_d82e_473d_98e1_a123b34cca7e
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1644
initial concentration: NaN
boundary condition: true
is: Q53Y41
name: DDC
constant: false
is: SBO:0000252

metaR r0732
kinetic law: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR 3AIBt
fast: false
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
type: Reaction
name: 3-amino-isobutyrate transport
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_525687a2_98ab_4219_812c_14419c13384e
is: Q53HM1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:54963
name: UCKL1
is: SBO:0000252

metaR H2O2tp
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
name: hydrogen peroxide peroxisomal transport via diffusion

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_fbb63fca_9ca3_406b_96cb_e24b1611c368
initial concentration: NaN
constant: false
boundary condition: true
name: TXNRD1
is encoded by: hsa:7296
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM ctp m
is: CHEBI:37563
is: HMDB00082
name: CTP(4-)
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

http://identifiers.org/biomodels.db/MODEL1310110034#_160dd224_c5c8_4dd5_96d9_b4fe62a52f4f
has only substance units: false
is encoded by: hsa:377841
constant: false
initial amount: NaN
type: Species
name: ENTPD8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q5MY95

metaM ppa e
has only substance units: false
is: HMDB00237
name: propionate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false

metaR GLYBtm
is described by: ECO:0000000
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
fast: false
product: MODEL1310110034#
is: SBO:0000185
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
type: Reaction
reversible: true
kinetic law: MODEL1310110034#

metaR CYSGLUexR
product: MODEL1310110034#
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR r0202
reactant: MODEL1310110034#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
type: Reaction

metaM dopasf e
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37946
name: dopamine 3-O-sulfate
constant: false
boundary condition: false
is: HMDB06275

metaR C3DCe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_346e41b7_b1fd_4fc6_a6e5_dbb68f818d4d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:47
initial amount: NaN
constant: false
type: Species
name: ACLY
is: SBO:0000252
has only substance units: false

metaR SUCCtp
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
name: succinate transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_72707a4d_e64f_4911_8fd7_c9ea70d2a247
is encoded by: hsa:2590
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: Q10471
type: Species
is: SBO:0000252
name: GALNT2

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM crm hs g
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:52639
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
has only substance units: false

metaR GLYt7 311 r
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110034#
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is described by: ECO:0000006

metaR LEUKTRB4t
fast: false
name: leukotriene B4 transport
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaM txa2 e
is: CHEBI:57445
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01452
initial amount: NaN
name: thromboxane A2(1-)
type: Species
has only substance units: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaR ST8SIA12
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.8
product: MODEL1310110034#
name: Beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaR RE3421R
name: RE3421
fast: false
product: MODEL1310110034#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:

metaR ASCBt4
product: MODEL1310110034#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
modifier: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000269
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110034#

metaR H2O2tn
reactant: MODEL1310110034#
is: SBO:0000185
name: hydrogen peroxide nuclear transport
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000

metaR r0730
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
modifier: MODEL1310110034#
reversible: false
product: MODEL1310110034#
type: Reaction
reactant: MODEL1310110034#
fast: false
is: SBO:0000176

metaR C80CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_27296237_adce_469c_a8e9_10c184104b0e
type: Species
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has part: Q9UHI5
has only substance units: false
boundary condition: true
constant: false

metaM ksi deg22 l
initial concentration: 1.0
is: CHEBI:16953
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial amount: NaN
is: HMDB00812
name: keratan sulfate I, degradation product 22

http://identifiers.org/biomodels.db/MODEL1310110034#_c9dd5ba8_c118_432d_8448_45f772481ce0
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: P59796
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:257202
name: GPX6
constant: false

metaM HC02217 c
constant: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin-g2
is: SBO:0000247
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
boundary condition: false
type: Species

metaR r2347
reversible: true
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR FRDPtc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110034#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: lipid, flip-flop intracellular transport
type: Reaction

metaR r0317
fast: false
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4

metaR H2O2tm
reactant: MODEL1310110034#
is: SBO:0000185
name: hydrogen peroxide mitochondrial transport
product: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110034#

metaR r0735
modifier: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110034#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110034#_da87254c_e739_432c_9c2f_e14e5303b3ff
is encoded by: hsa:8818
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: DPM2
type: Species

metaM galacglcgalgluside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
type: Species
is: CHEBI:17103
boundary condition: false
name: Lc4Cer
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM mlthf m
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00143
is: CHEBI:15636
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

http://identifiers.org/biomodels.db/MODEL1310110034#_d0fa9144_d341_43b4_ad1b_35aafb38b830
is: Q6IBB5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4694
initial amount: NaN
constant: false
name: NDUFA1
has only substance units: false
type: Species

metaR CO2ter
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

metaR r0450
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
is: SBO:0000176
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_cb0a4e8e_fa9f_4a97_b959_4169565c0bae
boundary condition: true
has only substance units: false
initial concentration: NaN
name: TAZ
type: Species
is: Q16635
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6901

metaM dheas c
is: SBO:0000247
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01032
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial amount: NaN
is: CHEBI:57905

http://identifiers.org/biomodels.db/MODEL1310110034#_693acd66_b9b2_44a1_afcb_a061e0665a9e
is: SBO:0000252
is encoded by: hsa:AL525798
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AL525798_1_c
constant: false

metaR GDPFUCtg
reactant: MODEL1310110034#
name: GDPFuc Golgi transport via CMP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
reversible: true
product: MODEL1310110034#

metaM lnlc e
is: HMDB00673
constant: false
name: linoleate
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
is: CHEBI:30245
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_f76c5c50_7e57_4f80_9ac7_9a5a035504fc
is: B2RDZ2
type: Species
initial amount: NaN
name: RFK
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55312

http://identifiers.org/biomodels.db/MODEL1310110034#_621d9073_c7d1_4eb3_b4a5_f7eb4482ab18
is: P56181
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4731
name: NDUFV3
is: SBO:0000252
initial concentration: NaN

metaM glyc c
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17754
is: C00116
is: HMDB00131
constant: false
has only substance units: false
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110034#_b933b6c7_dcb2_4192_bb8b_53bca9e18c19
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:64078
initial amount: NaN
has only substance units: false
constant: false
name: SLC28A3
is: Q9HAS3

http://identifiers.org/biomodels.db/MODEL1310110034#_8783bd69_02ea_460a_bb3b_e58ed0836159
initial concentration: NaN
type: Species
initial amount: NaN
name: INPP4B
is: SBO:0000252
is: O15327
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8821

metaR ILEt4
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
name: L-isoleucine transport in via sodium symport
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110034#_836bb738_9426_4c31_9240_a9a5644f63df
initial concentration: NaN
is encoded by: hsa:5277
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: PIGA
constant: false
is: SBO:0000252

metaR ALOX5
fast: false
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
product: MODEL1310110034#
name: Arachidonate 5-lipoxygenase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.13.11.34

metaM HC02217 e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
type: Species
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false

metaM 6dhf e
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
has only substance units: false
is: SBO:0000247
name: hexaglutamyl folate (DHF)
is: HMDB06563
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_32140b20_4e75_4218_89b6_754112226427
name: SLC38A3
is encoded by: hsa:10991
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q99624
is: SBO:0000252
initial concentration: NaN

metaM dmnoncoa c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB11604
name: 4,8 dimethylnonanoyl-CoA

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species
name: 20-hydroxy-arachidonate
is: CHEBI:34306
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c7392f67_5fd8_4a18_87c0_720d9ddb5ea7
name: NT5C
is: Q8TCD5
initial amount: NaN
is encoded by: hsa:30833
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM ppa m
initial amount: NaN
has only substance units: false
is: HMDB00237
name: propionate
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:17272
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: gamma-linolenate
is: SBO:0000247
has only substance units: false
is: HMDB03073
is: CHEBI:32391

metaR UGLCNACtg
is described by: ECO:0000269
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110034#

metaR UPP3S
product: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.75
reversible: false
is: SBO:0000176
fast: false
name: uroporphyrinogen-III synthase
modifier: MODEL1310110034#

metaR r0733
fast: false
type: Reaction
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaR EX gq1balpha hs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1balpha (homo sapiens) exchange
type: Reaction

metaM CE5101 m
boundary condition: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101

metaM dheas e
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: HMDB01032
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: CHEBI:57905
is: SBO:0000247

metaM ctp n
name: CTP(4-)
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00082
initial concentration: 1.0

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_81b26b7c_f543_4ce6_b719_c14c6cd52289
is encoded by: hsa:9153
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: O43868
is: SBO:0000252
constant: false
has only substance units: false
name: SLC28A2

http://identifiers.org/biomodels.db/MODEL1310110034#_c0d33758_6dd7_4515_901c_80262326dc05
constant: false
initial concentration: NaN
type: Species
is: P41222
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5730
boundary condition: true
name: PTGDS
initial amount: NaN

metaM HC02179 c
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
boundary condition: false
is: CHEBI:34306
is: SBO:0000247
constant: false
name: 20-hydroxy-arachidonate
initial amount: NaN
has only substance units: false

metaM glyc e
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00116
initial concentration: 1.0
is: HMDB00131
is: CHEBI:17754
constant: false
type: Species

metaR r0734
product: MODEL1310110034#
reversible: false
fast: false
reactant: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_cd2d1348_1cba_4d25_8507_33fee80f56e7
boundary condition: true
name: NDUFS4
is: O43181
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4724
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_e84ea04b_62a7_4f88_9794_f81e6ed3b967
is: SBO:0000252
has only substance units: false
name: PLCL1
is encoded by: hsa:5334
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q15111
type: Species
constant: false

metaR NACHEX18ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#

metaR r2346
reactant: MODEL1310110034#
fast: false
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
product: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR RE0344C
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110034#
reversible: true
name: RE0344
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110034#
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#

metaR GALASE12ly
type: Reaction
name: beta-galactosidase, lysosomal
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM ksii core2 deg7 l
initial concentration: 1.0
type: Species
notes: FORMULA: C44H73N4O30X CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16953
name: keratan sulfate II (core 2-linked), degradation product 7
has only substance units: false
initial amount: NaN
is: HMDB00812

metaR NACHEX26ly
product: MODEL1310110034#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false

metaR PROSTGE1t
reversible: true
modifier: MODEL1310110034#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110034#

metaR r2343
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
fast: false

metaR THYOXt
reactant: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
name: T4 transport via bicarbonate countertransport
product: MODEL1310110034#
is described by: ECO:0000269
reversible: true

metaM ksi deg18 l
type: Species
is: CHEBI:12936
initial amount: NaN
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: SBO:0000247
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 18
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110034#_a912c012_0952_4fa9_8e67_dd33e7a71dd0
boundary condition: true
has only substance units: false
is encoded by: hsa:J03866
constant: false
name: _J03866_1_m
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR r0208
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.4.1.1
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reversible: true
fast: false
product: MODEL1310110034#
type: Reaction

metaM crm hs r
name: N-acylsphingosine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaM btn m
has only substance units: false
is: HMDB00030
initial concentration: 1.0
name: biotinate
is: SBO:0000247
is: CHEBI:57586
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
constant: false
initial amount: NaN
type: Species

metaR r2030
reactant: MODEL1310110034#
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110034#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000

metaM ctp c
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
is: HMDB00082
has only substance units: false
boundary condition: false
is: C00063
constant: false
name: CTP
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:37563

metaM prostgi2 r
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01335
constant: false
name: prostaglandin I2(1-)

metaM glutcoa c
initial concentration: 1.0
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
type: Species
initial amount: NaN
name: glutaryl-CoA(5-)
has only substance units: false
is: HMDB01339
boundary condition: false
is: SBO:0000247

metaM 5adtststerone c
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
is: HMDB02961
type: Species
is: CHEBI:16330

http://identifiers.org/biomodels.db/MODEL1310110034#_7f9d15fd_6890_455b_a7fe_a92423e6eaf6
constant: false
name: ATP8A1
boundary condition: true
is: Q9Y2Q0
is encoded by: hsa:10396
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR XYLTt
fast: false
is: SBO:0000185
product: MODEL1310110034#
name: Xylitol transport via passive diffusion
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110034#

metaR r2344
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110034#
fast: false
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#
kinetic law: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_497cac9b_96f1_4609_9dd4_61f0a4ce3be9
is: SBO:0000252
name: AK7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:122481
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: Q96M32

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110034#
type: Reaction
name: riboflavin kinase
product: MODEL1310110034#

metaR MANtly
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110034#
name: mannose efflux from lysosome
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2f8b537c_67c6_43c9_b926_99ae293e0de9
constant: false
is: O43677
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: NDUFC1
is encoded by: hsa:4717
has only substance units: false
boundary condition: true

metaR r2341
product: MODEL1310110034#
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
reversible: true

metaM o2s m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: Superoxide anion
type: Species
is: HMDB02168
constant: false
is: CHEBI:18421
initial concentration: 1.0
boundary condition: false

metaR r1291
type: Reaction
is: SBO:0000185
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110034#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110034#_b6730091_8d2d_478b_9692_e8f1b7d11d4f
has only substance units: false
is: SBO:0000252
name: PIGH
is encoded by: hsa:5283
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q14442
initial concentration: NaN

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_33edeedb_ca63_4f6b_9ad2_8325d6ec2e01
type: Species
name: SLC8A3
boundary condition: true
constant: false
is encoded by: hsa:6547
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000212
is: SBO:0000176
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
kinetic law: MODEL1310110034#
reversible: true
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110034#

metaM pmtcoa x
initial amount: NaN
is: HMDB01338
boundary condition: false
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
type: Species
is: C00154

http://identifiers.org/biomodels.db/MODEL1310110034#_f0b08eb2_672a_4f81_b386_dbb64c3e46d3
initial amount: NaN
type: Species
is encoded by: hsa:AI285872
constant: false
boundary condition: true
name: _AI285872_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM o2s n
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02168
is: CHEBI:18421

http://identifiers.org/biomodels.db/MODEL1310110034#_8b13d56f_ebc9_405b_9d29_e3a718f765b8
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH3B2
type: Species
is encoded by: hsa:222
is: P48448
boundary condition: true

metaM ksi deg11 l
boundary condition: false
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 11
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00143
initial amount: NaN
type: Species
notes: FORMULA: C180H289N12O158S9 CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110034#_247d3b83_bf19_445d_b11e_2edbb2891786
boundary condition: true
name: ATP5E
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:514
initial amount: NaN
type: Species
has only substance units: false

metaR ANDRSTRNtr
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
name: androsterone intracellular transport

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_e35beb81_914a_4ec7_aa50_213c57259923
is: P31639
initial amount: NaN
has only substance units: false
type: Species
name: SLC5A2
constant: false
is encoded by: hsa:6524
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_d8619ed2_4be7_4b6e_9901_ed94a757829b
initial concentration: NaN
is: Q9Y6T7
is: SBO:0000252
constant: false
is encoded by: hsa:1607
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: DGKB

metaM dopasf c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false
is: SBO:0000247
name: dopamine 3-O-sulfate
is: CHEBI:37946
type: Species
is: HMDB06275
has only substance units: false

metaR DHPM1
is version of: http://identifiers.org/ec-code/3.5.2.2
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
reversible: false

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_7e8913df_2206_434d_8d73_b95b017793cf
name: SLC27A1
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:376497
is: Q6PCB7

http://identifiers.org/biomodels.db/MODEL1310110034#_3033f208_8b8a_407d_8b5c_2331a13148ea
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: GALNT8
is encoded by: hsa:26290
boundary condition: true
is: Q9NY28
type: Species

metaR r1292
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
kinetic law: MODEL1310110034#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
is: SBO:0000185
product: MODEL1310110034#

metaR GLCNACASE2ly
modifier: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110034#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal

metaR MTHFCm
fast: false
type: Reaction
kinetic law: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
reversible: true
reactant: MODEL1310110034#
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_707a68b7_5ef1_4982_aa4d_8ee789b42746
boundary condition: true
is: P50225
constant: false
has only substance units: false
type: Species
name: SULT1A1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6817
initial amount: NaN

metaM lnlncg l
is: CHEBI:32391
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
name: gamma-linolenate
has only substance units: false
is: SBO:0000247
is: HMDB03073
initial amount: NaN

metaM em2emgacpail prot hs r
initial concentration: 1.0
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: HMDB00086
has only substance units: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
type: Species
is: SBO:0000247
is: CHEBI:16870
initial amount: NaN
boundary condition: false

metaM cit c
constant: false
is: C00158
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16947
is: HMDB00094
initial amount: NaN

metaM HC01842 c
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
is: CHEBI:31997
is: SBO:0000247
name: Phosphodimethylethanolamine
constant: false
has only substance units: false

metaR RE1573M
reversible: true
modifier: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
name: RE1573
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_196dbdae_e498_4a39_8b25_980ce8167e43
name: IDH2
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: P48735
is encoded by: hsa:3418
is: SBO:0000252
has only substance units: false

metaM csn e
constant: false
initial amount: NaN
type: Species
is: CHEBI:16040
is: HMDB00630
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
name: cytosine
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR URIDK2m
fast: false
product: MODEL1310110034#
reversible: true
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110034#
name: uridylate kinase (dUMP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
kinetic law: MODEL1310110034#

metaR r0311
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110034#

metaR TETDEC2CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaM glyc m
is: SBO:0000247
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
initial amount: NaN
type: Species
is: C00116
is: CHEBI:17754
has only substance units: false
constant: false
is: HMDB00131
initial concentration: 1.0

metaM thf m
initial concentration: 1.0
is: C00101
initial amount: NaN
type: Species
constant: false
is: CHEBI:57453
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

http://identifiers.org/biomodels.db/MODEL1310110034#_1c6a5308_6f31_4182_b9f9_223c5e8d9d81
name: NDUFA9
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4704
is: Q16795

metaM ctp e
is: HMDB00082
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:37563
name: CTP(4-)

metaM hs deg17 l
name: heparan sulfate, degradation product 17
is: HMDB02704
initial amount: NaN
is: CHEBI:21338
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
boundary condition: false
constant: false
is: SBO:0000247

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM cit e
type: Species
is: CHEBI:16947
has only substance units: false
name: citrate(3-)
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM ppa c
constant: false
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00237
is: CHEBI:17272
name: propionate

metaM pmtcoa r
initial concentration: 1.0
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
is: CHEBI:3454
is: C00154
type: Species
boundary condition: false
constant: false

metaM HC01399 x
constant: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:27466
is: SBO:0000247
type: Species
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0

metaR GLUPROASCT1
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000134
name: glutamate intake by system ASCT-1 transporter
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.

metaM txa2 r
type: Species
has only substance units: false
is: CHEBI:57445
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247
constant: false
boundary condition: false
name: thromboxane A2(1-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01452

metaR r0885
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110034#
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
product: MODEL1310110034#

metaM cs a deg1 l
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16953
boundary condition: false
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species
is: HMDB00812

metaM csn c
type: Species
name: cytosine
is: HMDB00630
has only substance units: false
boundary condition: false
is: CHEBI:16040
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110034#_2cfbb4e9_d557_42da_aec1_7b1eb7dcf3f9
initial concentration: NaN
name: GCK
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2645
constant: false
is: Q53Y25

metaM m2mn l
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: HMDB06537
has only substance units: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_cacb99af_915b_4c3d_b951_d78ba201f769
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: P37268
is encoded by: hsa:2222
has only substance units: false
name: FDFT1

metaM pchol hs c
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16110
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM met L e
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16643
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_29ceb5df_23c6_4de3_a177_5e47bca358c6
initial concentration: NaN
type: Species
name: BDH1
initial amount: NaN
is encoded by: hsa:622
constant: false
has only substance units: false
is: Q02338
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_723828e8_466d_4936_a91e_f353a4ebfe18
boundary condition: true
type: Species
has only substance units: false
name: PGM3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B4DX94
constant: false
is encoded by: hsa:5238

metaR TYRt
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
name: L-tyrosine transport
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
product: MODEL1310110034#

metaM HC02210 e
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:34939
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d3
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110034#_7041d51b_bf67_4797_b3d3_4e799fd8bbb0
boundary condition: true
is encoded by: hsa:6534
initial amount: NaN
type: Species
is: Q99884
has only substance units: false
name: SLC6A7
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e0300bac_fa1f_4817_ab8b_6f26317470af
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:522
boundary condition: true
name: ATP5J
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_f6b981d9_1349_49c8_83a2_32b65d1dca0b
initial concentration: NaN
is encoded by: hsa:3030
has only substance units: false
type: Species
is encoded by: hsa:3032
has part: P55084
name: HADHA:HADHB
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000297
has part: E9KL44

metaR r2026
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110034#

metaM tchola c
type: Species
boundary condition: false
is: CHEBI:36257
constant: false
initial concentration: 1.0
is: HMDB00036
has only substance units: false
is: SBO:0000247
name: taurocholic acid
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaR ST6GALNAC27
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.7
kinetic law: MODEL1310110034#
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110034#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
product: MODEL1310110034#

metaM fe2 c
initial concentration: 1.0
is: HMDB00692
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
initial amount: NaN
is: CHEBI:29033
type: Species
name: Fe2+
has only substance units: false
is: C00023
boundary condition: false

metaR DTTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110034#
type: Reaction
product: MODEL1310110034#
reversible: true
is: SBO:0000185
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110034#
is described by: ECO:0000000
fast: false

metaM o2s c
name: superoxide
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
boundary condition: false
initial concentration: 1.0
type: Species

metaR MTHFD2
reversible: true
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110034#
modifier: MODEL1310110034#

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
is described by: ECO:0000000
reactant: MODEL1310110034#
name: Gamma-glutamyltransferase
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110034#
reversible: true
product: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_e1fb4ea4_3036_4302_b991_080a8c3cf4fa
type: Species
initial concentration: NaN
is: P13929
has only substance units: false
constant: false
is: SBO:0000252
name: ENO3
is encoded by: hsa:2027
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_859f50e9_03c2_4b89_9afc_9d8e603d54f1
name: KHK
is encoded by: hsa:3795
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: P50053

metaM so4 m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
has only substance units: false
boundary condition: false
is: HMDB01448
name: sulfate
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_2881c203_2651_4823_8920_778b5f7c92f0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:155184
boundary condition: true
type: Species
is: Q6PXP3
initial amount: NaN
name: SLC2A7
has only substance units: false
constant: false

metaR MCLACCYSR
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: 3-mercaptolactate:cysteine reductase
reversible: false
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reactant: MODEL1310110034#

metaR METyLATthc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM pchol hs e
constant: false
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c9815cca_ede7_444b_aad4_97def8498524
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: GGT2
boundary condition: true
is encoded by: hsa:728441
has only substance units: false

metaM pre prot r
has only substance units: false
initial amount: NaN
notes: FORMULA: XY CHARGE: 0
is: CHEBI:16240
type: Species
initial concentration: 1.0
boundary condition: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: SBO:0000247
constant: false
is: HMDB03125

metaM fum m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: C00122
is: SBO:0000247
is: CHEBI:29806
is: HMDB00134
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate

metaR DNDPt29m
kinetic law: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is: SBO:0000185
name: dCDP transport via dADP antiport
is described by: ECO:0000269
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#

metaM mlthf c
constant: false
is: CHEBI:15636
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01533
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143

http://identifiers.org/biomodels.db/MODEL1310110034#_ac4454e7_49cc_438f_a78c_911adf4cc0e0
name: GOT2
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: P00505
is encoded by: hsa:2806

metaM tchola e
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0
boundary condition: false
constant: false
is: HMDB00036
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: taurocholic acid
has only substance units: false

metaM so4 l
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01448

metaM o2s e
initial amount: NaN
is: SBO:0000247
is: CHEBI:18421
constant: false
name: superoxide
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
type: Species
boundary condition: false
initial concentration: 1.0

metaR NACDe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM fe2 e
is: HMDB00692
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
type: Species
name: Fe2+
is: C00023
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a2b2f20d_e656_4f2b_b955_e849253a1f7f
is encoded by: hsa:4830
is: P15531
initial concentration: NaN
is: SBO:0000252
name: NME1
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM apoC Lys m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Apocarboxylase (Lys residue)
initial amount: NaN
is: CHEBI:32551
constant: false
is: HMDB00182
boundary condition: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110034#_dbb869d7_21ed_4fe4_927c_57dd9f23b234
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: OXCT1
is encoded by: hsa:5019
is: P55809
boundary condition: true
initial concentration: NaN

metaR NACHEX15ly
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
modifier: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d7abbe4e_5d63_4172_a669_def69cb2b4ff
name: ATP5G3
initial amount: NaN
is encoded by: hsa:518
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR HS4ly
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110034#
name: heparan-N-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110034#

metaR XYLt
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
name: D-xylose reversible transport
reactant: MODEL1310110034#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_93bbcc49_2b15_40af_8356_a82e153e8b41
is: SBO:0000252
is encoded by: hsa:4710
initial concentration: NaN
is: O95168
boundary condition: true
has only substance units: false
type: Species
name: NDUFB4
initial amount: NaN
constant: false

metaR PRAGSr
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110034#
fast: false
name: phosphoribosylglycinamide synthase
is version of: http://identifiers.org/ec-code/2.1.2.2
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110034#
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_79aa0732_9f5d_4c8d_8e32_aa49d63ccbe4
is: SBO:0000252
constant: false
is encoded by: hsa:386757
boundary condition: true
type: Species
initial amount: NaN
name: SLC6A10P
initial concentration: NaN
has only substance units: false

metaR FRDPtr
reversible: true
is: SBO:0000185
reactant: MODEL1310110034#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
kinetic law: MODEL1310110034#
name: lipid, flip-flop intracellular transport
product: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_8eacf21b_ae52_4fb9_96ef_90243f248595
is: SBO:0000252
type: Species
is encoded by: hsa:8560
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: DEGS1
has only substance units: false

metaM pcrn x
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
type: Species
initial concentration: 1.0
name: propionyl-carnitine
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

metaM thf c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: CHEBI:57453
is: C00101
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2331d9f7_64b2_4a47_9a78_6071c3cd9f82
name: TM7SF2
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7108
is: O76062
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR DNDPt17m
product: MODEL1310110034#
name: dUDP transport via dCDP antiport
modifier: MODEL1310110034#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false

metaM but m
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
has only substance units: false
is: HMDB00039
initial amount: NaN
is: CHEBI:17968
type: Species
name: butyrate
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_afb5bc70_ad94_45d3_888d_9190d6dc362d
is encoded by: hsa:51477
is: B3KRT1
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ISYNA1

http://identifiers.org/biomodels.db/MODEL1310110034#_ca980559_9ef7_459a_9111_fea5fc702bd8
is encoded by: hsa:AI090874
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI090874_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_daea43a1_df81_46ad_90bc_848eb7a819ea
name: PPCDC
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:60490
is: SBO:0000252
is: Q96CD2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_870928ac_67c9_4383_8881_7ece707e99a7
is encoded by: hsa:6536
has only substance units: false
boundary condition: true
name: SLC6A9
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: B7Z3W8

metaR RE3272N
product: MODEL1310110034#
name: RE3272
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_544bdee6_6624_43e2_9989_37437f1e4573
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: _AW277253_1_c
initial amount: NaN
is encoded by: hsa:AW277253
is: SBO:0000252

metaR DUDPtn
name: dUDP nuclear transport
kinetic law: MODEL1310110034#
reversible: true
reactant: MODEL1310110034#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false

metaR S3TASE2ly
is: SBO:0000176
type: Reaction
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_32bd4eb9_e795_4d29_adbd_407aee825773
is encoded by: hsa:4694
is: SBO:0000252
is: Q6IBB5
boundary condition: true
has only substance units: false
constant: false
type: Species
name: NDUFA1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c4b952c4_90e5_44dc_8f38_a5da3347928f
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: PLCB4
initial amount: NaN
initial concentration: NaN
is: E2QRH8
is encoded by: hsa:5332
has only substance units: false

metaM pail5p hs n
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_02419376_6885_4754_8ef7_7f540c5d30f0
constant: false
initial amount: NaN
is: P15289
is encoded by: hsa:410
name: ARSA
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_adcb02d6_0d09_4675_8e5f_50cc46d6d660
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: COL4A3BP
is: Q9Y5P4
is encoded by: hsa:10087

http://identifiers.org/biomodels.db/MODEL1310110034#_aef34dab_6b2c_4e3f_ad07_6188b0926cc0
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: _AI971036_1_c
is encoded by: hsa:AI971036
is: SBO:0000252
constant: false
boundary condition: true

metaR H2MTer U
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
product: MODEL1310110034#
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110034#
type: Reaction
fast: false
reactant: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_d93b9a22_69fa_4b03_880d_6228476306e7
has only substance units: false
type: Species
has part: Q6NZ59
initial amount: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
initial concentration: NaN
boundary condition: true
constant: false

metaR ARACHDCOAtx
kinetic law: MODEL1310110034#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000000
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c9fc8377_e53d_476a_b5ba_e8dbe7e035b3
name: ALDH1A3
constant: false
is: SBO:0000252
is encoded by: hsa:220
boundary condition: true
has only substance units: false
is: P47895
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_7505943a_5051_4e24_aa1a_23c83e943ce5
has only substance units: false
name: NNT
constant: false
is encoded by: hsa:23530
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaR APOCF
reversible: false
kinetic law: MODEL1310110034#
name: Apocarboxylase formation
product: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110034#

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaM 5adtststerone e
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02961
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
constant: false
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_1bb522cf_da6c_4574_933c_9219551fc8d4
has only substance units: false
is: Q9UNK4
initial concentration: NaN
type: Species
name: PLA2G2D
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:26279
boundary condition: true

metaR C121CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR SUBERCROT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_707b3930_7092_4c0c_8b90_bb943a779618
is: F8VQS7
has only substance units: false
is encoded by: hsa:55967
initial amount: NaN
is: SBO:0000252
name: NDUFA12
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_35d6d0f9_bce1_4a9a_9444_b89ca5a169fe
is: E9PB82
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: HSD17B4
has only substance units: false
initial amount: NaN
is encoded by: hsa:3295

metaR GLUTCOAACBP
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM apoC Lys c
boundary condition: false
is: HMDB00182
is: CHEBI:32551
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
initial amount: NaN

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
is: CHEBI:15374
boundary condition: false
is: HMDB02281
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
type: Species
constant: false

metaR ANDRSTRNte
name: androsterone transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR ABTD
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: true

metaR PI45PLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction
kinetic law: MODEL1310110034#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110034#
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_4ac13ad0_2f5e_4aae_a2e2_3e2edb94fcc8
constant: false
is encoded by: hsa:200010
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: E9PAK4
name: SLC5A9
type: Species
has only substance units: false
initial amount: NaN

metaR ADPACTD
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_2e21c9aa_d56d_4e97_8b9e_b0b683552645
is: SBO:0000252
is: O00341
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6512
constant: false
name: SLC1A7
boundary condition: true

metaM thmmp c
constant: false
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial concentration: 1.0
is: CHEBI:37575
is: HMDB02666
is: C01081
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: Thiamin monophosphate

metaR 3SALATAim
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110034#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
reversible: false

metaR r0727
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110034#
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR r1971
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110034#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false

metaR SMPD3g
reversible: false
product: MODEL1310110034#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.12
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
reactant: MODEL1310110034#

metaR r0726
product: MODEL1310110034#
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction

metaM pchol hs m
is: SBO:0000247
is: CHEBI:16110
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial amount: NaN
has only substance units: false
name: Phosphatidylcholine
boundary condition: false
constant: false

metaR UMPKn
fast: false
reactant: MODEL1310110034#
is described by: ECO:0000269
modifier: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110034#
name: UMP kinase, nuclear
product: MODEL1310110034#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_294bd676_9600_4563_97dd_a817dafe0244
has only substance units: false
is: SBO:0000252
name: ECHS1
type: Species
initial concentration: NaN
boundary condition: true
is: P30084
initial amount: NaN
constant: false
is encoded by: hsa:1892

metaM so4 e
constant: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
type: Species
initial concentration: 1.0
name: sulfate
is: CHEBI:16189
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM CE5788 e
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
name: kinetensin 1-7
is: HMDB02710
is: CHEBI:27485
boundary condition: false
initial amount: NaN

metaM fe2 m
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: Fe2+
is: CHEBI:29033
is: SBO:0000247
is: C00023
has only substance units: false
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: HMDB00692

metaR GLYPHEHYc
kinetic law: MODEL1310110034#
name: hydrolysis of glycylphenylalanine
reversible: true
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is described by: ECO:0000134
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_2a00b2da_27f0_4b59_a04f_0bd19c9f3712
is encoded by: hsa:286016
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: TPI1P2

metaM 5adtststerone r
is: HMDB02961
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16330
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one

http://identifiers.org/biomodels.db/MODEL1310110034#_b1fbe754_aca5_4e47_ab9d_b54a63686eca
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR r1972
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000185
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GP1CALPHAte
reactant: MODEL1310110034#
name: gp1calpha hs transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110034#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110034#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_be1a0e21_c5e4_4547_b2ec_28a1f7b55787
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFS7
type: Species
is: O75251
is encoded by: hsa:374291
initial amount: NaN
initial concentration: NaN

metaM asp D x
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:29990
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
is: HMDB06483
initial concentration: 1.0
name: D-aspartate(1-)

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reversible: false
kinetic law: MODEL1310110034#

metaM oh1 e
constant: false
is: HMDB01039
boundary condition: false
is: C01328
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: hydroxide ion
initial amount: NaN
type: Species
notes: FORMULA: HO CHARGE: -1

metaR NH4t3r
kinetic law: MODEL1310110034#
name: ammonia transport via proton antiport
type: Reaction
reactant: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000269

metaR C100CPT1
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_497cae8c_cc17_413e_9a43_853054f7f18f
is: P55084
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: HADHB
is encoded by: hsa:3032
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR GULLACter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110034#
type: Reaction
name: gulonolactone endoplasmic reticular transport
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000185
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_303b9432_a7bd_4fd2_a3d1_78fe3605e23d
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NDUFS6
is encoded by: hsa:4726
is: Q6IBC4
type: Species

metaM fum c
is: CHEBI:29806
is: HMDB00134
name: Fumarate
type: Species
has only substance units: false
is: C00122
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_3a04be08_196e_458f_bfe4_2a27064797db
initial amount: NaN
constant: false
is encoded by: hsa:6715
has only substance units: false
boundary condition: true
name: SRD5A1
is: SBO:0000252
is: P18405
type: Species
initial concentration: NaN

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR FAOXC12DCc
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_b8842d5f_ce16_4924_b068_04f9e8d542af
initial amount: NaN
boundary condition: true
is encoded by: hsa:2194
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P49327
has only substance units: false
name: FASN

metaM so4 c
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: HMDB01448
constant: false
name: sulfate
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_08429ff8_8770_43f2_8766_f4d6a12dab0d
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PLA2G2E
is: SBO:0000252
type: Species
is: Q9NZK7
is encoded by: hsa:30814
constant: false

metaR PIPLC
product: MODEL1310110034#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
reversible: false
kinetic law: MODEL1310110034#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110034#
modifier: MODEL1310110034#

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
name: butyrate
is: CHEBI:17968
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00039
constant: false
boundary condition: false

metaR DOPAt4 2 r
reactant: MODEL1310110034#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110034#
reversible: true
type: Reaction
product: MODEL1310110034#
is: SBO:0000185
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)

http://identifiers.org/biomodels.db/MODEL1310110034#_b92a499c_329b_416e_8cb9_0630fd23cfb6
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AU149534_1_m
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AU149534
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_49c63a8f_29e0_45f2_ad6a_0b4e589ea8b0
is: Q9NX14
is: SBO:0000252
name: NDUFB11
type: Species
boundary condition: true
constant: false
is encoded by: hsa:54539
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR GALASE19ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110034#
fast: false
product: MODEL1310110034#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110034#

metaM fol m
name: Folate
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
initial concentration: 1.0
type: Species
is: CHEBI:27470
constant: false
initial amount: NaN
is: HMDB00121
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_37db145d_4f86_4967_b626_6e13612cc05a
has only substance units: false
boundary condition: true
name: CDA
is encoded by: hsa:978
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: P32320
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_a884a732_f039_466d_a9a4_3f4bf0329035
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: _AI971036_1_x
is encoded by: hsa:AI971036
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_fe24ab91_5330_4825_aab7_0c40ec9a0b6c
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:728637
initial concentration: NaN
initial amount: NaN
type: Species
name: _728637_1_c
constant: false

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01039
has only substance units: false
name: hydroxide ion
is: SBO:0000247
is: C01328

metaR GP1CALPHAtg
name: gp1calpha hs intracellular transport
fast: false
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110034#
type: Reaction
reversible: true
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000185

metaR ADPCOACROT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR S4TASE5ly
type: Reaction
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110034#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110034#
product: MODEL1310110034#

metaM C02470 c
is: C02470
is: http://identifiers.org/pubchem.compound/5485
has only substance units: false
name: Xanthurenic acid
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
constant: false
type: Species
is: SBO:0000247
is: HMDB00881

metaR RE1517M
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110034#
name: RE1517
is: SBO:0000176
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_1da6620b_8520_4634_8426_78840c9bdc98
has only substance units: false
type: Species
name: DGKD
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:8527
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_7e0e12bb_96a6_49fc_83bb_f56a364a9f45
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1757
name: SARDH
initial amount: NaN
initial concentration: NaN
is: A8K596

metaM HC02210 c
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d3
has only substance units: false

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:57781
initial concentration: 1.0
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
boundary condition: false

metaM met L c
constant: false
is: HMDB00696
is: CHEBI:16643
boundary condition: false
initial amount: NaN
type: Species
name: L-methionine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

metaR ST6GALNAC26
reactant: MODEL1310110034#
reversible: false
is: SBO:0000176
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
fast: false
is described by: ECO:0000304
modifier: MODEL1310110034#
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.7

metaR LEUTA
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110034#
is: SBO:0000176
name: leucine transaminase
modifier: MODEL1310110034#
kinetic law: MODEL1310110034#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
product: MODEL1310110034#
type: Reaction

metaM but c
is: CHEBI:17968
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
constant: false
name: butyrate
initial amount: NaN
is: HMDB00039

http://identifiers.org/biomodels.db/MODEL1310110034#_54f39791_32ce_434b_9d7e_d9a93797f7c6
boundary condition: true
constant: false
is encoded by: hsa:54965
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q8TBF5
name: PIGX

metaR r0729
type: Reaction
reversible: false
product: MODEL1310110034#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reactant: MODEL1310110034#

metaR q10h2tc
is: SBO:0000185
kinetic law: MODEL1310110034#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110034#
name: transport of ubiquinol into cytosol
reversible: true
fast: false

metaR ST6GALNAC25
reversible: false
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
fast: false
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.4.99.7
is: SBO:0000176
modifier: MODEL1310110034#
reactant: MODEL1310110034#
type: Reaction

metaR ILEt5m
product: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
reactant: MODEL1310110034#
fast: false
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
reversible: true

metaR SULFOX
is described by: ECO:0000134
is: SBO:0000185
modifier: MODEL1310110034#
reversible: false
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14729666 NOTES:MM/TDV; r0140
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.8.3.1
fast: false
name: sulfite oxidase

metaM pmtcoa c
is: C00154
type: Species
constant: false
initial amount: NaN
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_a0fcc35f_41a6_43d9_bebc_9fe8ccd7e29b
is: P07864
boundary condition: true
name: LDHC
constant: false
type: Species
is encoded by: hsa:3948
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR GLCt1r
reactant: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
type: Reaction
name: glucose transport (uniport)
reversible: true
modifier: MODEL1310110034#
is described by: ECO:0000269
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
fast: false

metaM ksi deg28 l
type: Species
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 28
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16953
constant: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
is: HMDB00812

metaR RE0383C
reversible: true
fast: false
product: MODEL1310110034#
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110034#

metaM ethamp c
is: HMDB00224
is: CHEBI:58190
name: ethamp[c]
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_880f39c7_1dcb_4da0_a4cd_e5ba903933a4
is encoded by: hsa:4846
constant: false
initial amount: NaN
name: NOS3
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: A0S0A7

http://identifiers.org/biomodels.db/MODEL1310110034#_8c3296cd_d641_4f32_80d1_804b0c12862e
name: MTMR3
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:8897
initial concentration: NaN
type: Species
initial amount: NaN

metaM CE1926 e
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
has only substance units: false
name: gama-carboxyethyl-hydroxychroman
constant: false
initial amount: NaN
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

metaR ARGLYSex
type: Reaction
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is described by: ECO:0000269
fast: false
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Arginine/Lysine exchanger (Arg in)

metaM for c
name: Formate
constant: false
is: CHEBI:15740
is: HMDB00142
is: SBO:0000247
is: C00058
initial concentration: 1.0
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_56162440_6c3d_450d_bf51_c188837dafcf
is encoded by: hsa:2584
has only substance units: false
constant: false
is: SBO:0000252
is: P51570
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GALK1

metaR FUCtly
reactant: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
name: L-fucose efflux from lysosome
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
type: Reaction
is: SBO:0000185

metaR B3GALT44g
name: Beta-1,3-galactosyltransferase 4
is described by: ECO:0000269
modifier: MODEL1310110034#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.62
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_5baa9571_ca52_4f48_959b_98dcf3e8d93d
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACSL5
has only substance units: false
is: Q9ULC5
initial concentration: NaN
is encoded by: hsa:51703
type: Species

metaR CYTD
type: Reaction
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
kinetic law: MODEL1310110034#
name: cytidine deaminase
fast: false
reversible: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110034#

metaM mercplac c
initial concentration: 1.0
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
constant: false
name: 3-Mercaptolactate
is: C05823
is: http://identifiers.org/pubchem.compound/8118
is: HMDB02127
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a1f19bcb_cbba_45d9_bcec_0abdc7e27231
name: ACADM
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:34
type: Species
constant: false
initial concentration: NaN
is: P11310
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_1a82ec73_3a6c_42ed_9f29_ecdf17fd1931
initial amount: NaN
name: DHFR
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P00374
is encoded by: hsa:1719

metaR THYOXt2
reactant: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
name: T4 transport via facilitated diffusion
type: Reaction
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
product: MODEL1310110034#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_fae4c2d4_c70a_4f2d_b4db_ec4d3160cda4
is: P30838
name: ALDH3A1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:218
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_2a86eb8f_76ff_4892_919c_1caed40d7acc
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ALDH3A2
constant: false
type: Species
is encoded by: hsa:224
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110034#_f76a9ae0_bb7e_43ca_948f_0d170f4a84e6
name: SLC35B2
initial concentration: NaN
is: Q8TB61
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:347734

http://identifiers.org/biomodels.db/MODEL1310110034#_29b88630_2cad_4938_89e9_e0e7fcf98a15
type: Species
is: SBO:0000252
is: P49753
initial amount: NaN
name: ACOT2
constant: false
has only substance units: false
is encoded by: hsa:10965
initial concentration: NaN
boundary condition: true

metaR NACHEX20ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
is described by: ECO:0000000
modifier: MODEL1310110034#
product: MODEL1310110034#
fast: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110034#_bbc67864_1bd0_46c2_8109_2518ea04bd7f
is encoded by: hsa:9107
initial amount: NaN
name: MTMR6
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q9Y217
is: SBO:0000252

metaR UAG4E
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110034#
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110034#
name: UDP-N-acetylglucosamine 4-epimerase
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR S6TASE11ly
modifier: MODEL1310110034#
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110034#
reversible: true
type: Reaction

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110034#
is: SBO:0000176
reactant: MODEL1310110034#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110034#
type: Reaction
kinetic law: MODEL1310110034#
name: UMP kinase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_a0e6f7df_c3a7_4d75_9bc7_8582c95113d8
is encoded by: hsa:4952
initial concentration: NaN
name: OCRL
has only substance units: false
is: Q01968
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR DDPGAm
reactant: MODEL1310110034#
is described by: ECO:0000000
kinetic law: MODEL1310110034#
is: SBO:0000176
product: MODEL1310110034#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial

metaR BUTt2r
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reversible: true
name: Butyrate transport via proton symport, reversible
type: Reaction
reactant: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110034#_0dfe38a1_4eb2_4f2f_b040_31ec3f3e31cd
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:93034
is: B3KUK6
name: NT5C1B
constant: false
boundary condition: true

metaR 4ABUTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reactant: MODEL1310110034#
type: Reaction
reversible: true
name: 4-aminobutanoate mitochondrial transport via diffusion
kinetic law: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110034#

metaR NAGLCAly
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
type: Reaction
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_a415d99a_1596_47d7_8a70_d76b6896563d
is: Q8NFF2
name: SLC24A4
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:123041
has only substance units: false
boundary condition: true

metaR r1608
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110034#
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110034#_4e994e63_5af3_448d_8e2b_12c82b05f5d0
is encoded by: hsa:3155
is: Q6IBC0
constant: false
name: HMGCL
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR ATP1ter
kinetic law: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
name: ADP/ATP transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
reversible: true

metaR TETDECE1CRNe
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_146c3c73_bfa2_410f_b9e3_40657732d310
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9365
is: Q9UEF7
name: KL
boundary condition: true
has only substance units: false
constant: false

metaR TAUPAT1c
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaR r1609
fast: false
reactant: MODEL1310110034#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110034#_0dea6bcc_4d68_4b9b_92a4_8b2220cb5691
type: Species
is: SBO:0000252
is encoded by: hsa:7296
initial amount: NaN
name: TXNRD1
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_28ef0980_30a4_493f_a8af_f13e9dfe82e1
constant: false
type: Species
is encoded by: hsa:112
initial amount: NaN
has only substance units: false
boundary condition: true
name: ADCY6
is: SBO:0000252
initial concentration: NaN

metaM 3aib D m
is: C03265
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02299
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
name: D-3-Amino-isobutanoate

metaR 3AIBtm
is: SBO:0000185
modifier: MODEL1310110034#
product: MODEL1310110034#
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110034#
name: 3-amino-isobutyrate transport, mitochondrial
type: Reaction

metaR PGSr
product: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
name: Prostaglandin G/H synthase
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/1.14.99.1
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110034#_6bce66a6_221d_4bd4_a207_19dcab60289e
boundary condition: true
initial amount: NaN
is encoded by: hsa:10768
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O43865
name: AHCYL1
constant: false
type: Species

metaM lpam m
constant: false
initial amount: NaN
has only substance units: false
name: lipoamide
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
is: HMDB00962
is: CHEBI:17460
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_ea8e37bd_1a69_433c_b3e8_2d8f71df2202
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA526438
is: SBO:0000252
has only substance units: false
name: _AA526438_1_c
initial concentration: NaN

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_f22556d8_48e0_4507_9801_8245d961592b
boundary condition: true
is encoded by: hsa:5142
is: Q5TEK5
name: PDE4B
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM ksi deg17 l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 17
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: CHEBI:12936
boundary condition: false
has only substance units: false
is: HMDB00143
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_e0c2018f_e207_4633_a3af_c3eff01409b5
is: Q02742
type: Species
name: GCNT1
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2650
initial concentration: NaN
has only substance units: false

metaM HC00460 c
is: SBO:0000247
is: CHEBI:58044
has only substance units: false
boundary condition: false
constant: false
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628

metaM bilirub e
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57977
is: HMDB00054
type: Species
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)

metaM crn m
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16347
name: L-Carnitine
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00318
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM dmnoncoa x
is: HMDB11604
boundary condition: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial amount: NaN
constant: false

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR DITPtn
product: MODEL1310110034#
kinetic law: MODEL1310110034#
fast: false
reversible: true
reactant: MODEL1310110034#
is: SBO:0000185
name: dITP nuclear transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110034#_c1d2a7b5_be02_4818_bca2_cb3e8fb9438b
initial amount: NaN
name: PIK3C2A
type: Species
initial concentration: NaN
is: O00443
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5286
constant: false
has only substance units: false

metaR NDP3ex
is described by: ECO:0000269
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
reversible: false
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
reactant: MODEL1310110034#
type: Reaction
is: SBO:0000176
product: MODEL1310110034#
modifier: MODEL1310110034#

metaM ser L e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
is: HMDB00187
initial concentration: 1.0
initial amount: NaN
name: L-serine
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17115

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: CHEBI:15740
constant: false
name: formate
is: HMDB00142
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM cs e l
is: SBO:0000247
is: HMDB06202
initial amount: NaN
type: Species
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110034#_8108ed31_f36c_4ead_b7a0_1287ba55e79a
boundary condition: true
name: NDUFB4
initial concentration: NaN
is encoded by: hsa:4710
type: Species
is: SBO:0000252
is: O95168
initial amount: NaN
constant: false
has only substance units: false

metaM hxan x
name: Hypoxanthine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17368
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB00157

metaM 5oxpro e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57606
is: HMDB00267
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
boundary condition: false
name: 5-oxoprolinate
initial amount: NaN
type: Species

metaR r2420
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
product: MODEL1310110034#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110034#
is: SBO:0000185

metaR SEBCOACROT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaM fgam c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426
is: SBO:0000247
is: HMDB01308
type: Species
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: C04376
initial amount: NaN

metaR FUCFUCGALACGLCGALGLUSIDEtg
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
product: MODEL1310110034#
fast: false
is: SBO:0000185

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_37f9a7a5_3c57_447f_b952_d2c4ae55f7e9
is encoded by: hsa:341947
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: COX8C
is: Q7Z4L0

http://identifiers.org/biomodels.db/MODEL1310110034#_4d2a0dee_ebec_4594_9323_30973c9f94f3
initial amount: NaN
name: _AI222095_1_e
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AI222095
boundary condition: true
has only substance units: false

metaM ncam c
notes: FORMULA: C6H6N2O CHARGE: 0
boundary condition: false
is: SBO:0000247
is: CHEBI:0
name: Nicotinamide
type: Species
is: C00153
initial concentration: 1.0
is: HMDB01406
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_fb73ac9d_d56e_4b82_b2d6_e4cb46f1c30d
is: SBO:0000252
is encoded by: hsa:2583
boundary condition: true
name: B4GALNT1
type: Species
is: Q59FK0
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_45ee864c_9db5_4fb3_9787_7bffec9ba4a8
boundary condition: true
constant: false
name: CPT2
is encoded by: hsa:1376
is: P23786
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM acnam n
initial concentration: 1.0
is: HMDB00230
constant: false
initial amount: NaN
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_84d89afa_b6cb_497b_88b4_b38edf85e41b
name: MTHFR
initial amount: NaN
is encoded by: hsa:4524
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q59GJ6
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_4294e4fd_67e6_47ea_8c80_17bc150d7297
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8574
name: AKR7A2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O43488
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_38990fd4_1c99_48bd_be4f_c4afc8025ebd
initial amount: NaN
has only substance units: false
constant: false
is: Q6LEN5
name: CHAT
is encoded by: hsa:1103
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR XANDp
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110034#
fast: false
modifier: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
reversible: false
type: Reaction
product: MODEL1310110034#
is: SBO:0000176
is described by: ECO:0000269
name: xanthine dehydrogenase, peroxisomal

metaM 5oxpro c
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57606
name: 5-oxoprolinate
is: HMDB00267
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_cce76db6_b606_4a20_b65c_2fdb7c8f00ee
boundary condition: true
constant: false
is encoded by: hsa:29968
has only substance units: false
is: Q9Y617
is: SBO:0000252
name: PSAT1
initial concentration: NaN
initial amount: NaN
type: Species

metaM CE5236 n
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28002
type: Species
initial concentration: 1.0
is: HMDB03952
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_e2fa7936_8b9e_47ef_909f_120bf4975634
has only substance units: false
initial amount: NaN
is encoded by: hsa:BF195998
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: _BF195998_1_x
is: SBO:0000252

metaM c3dc c
is: HMDB02095
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: malonyl carnitine
notes: FORMULA: C10H16NO6 CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110034#_0c8b5ca0_fb21_40b3_b5ae_7473f6d9405c
name: PTEN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5728
has only substance units: false
boundary condition: true
is: F6KD01
initial amount: NaN

metaM HC02180 c
has only substance units: false
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
is: SBO:0000247
is: CHEBI:28728

metaM ser L c
is: SBO:0000247
is: HMDB00187
type: Species
initial concentration: 1.0
has only substance units: false
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
boundary condition: false
is: CHEBI:17115
constant: false

metaR MCITS
product: MODEL1310110034#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110034#
name: 2-methylcitrate synthase

http://identifiers.org/biomodels.db/MODEL1310110034#_9e0ed39f_d646_4414_be69_c313af4e5387
is encoded by: hsa:1808
has only substance units: false
name: DPYSL2
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: B4DR31
type: Species
initial concentration: NaN

metaR GLCAASE9ly
fast: false
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
is: SBO:0000176
reversible: false

metaM hcys L c
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-homocysteine
has only substance units: false
is: HMDB00742
is: CHEBI:17588

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM acnam l
has only substance units: false
is: CHEBI:35418
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0
is: HMDB00230

metaM bilirub r
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57977
is: HMDB00054
initial amount: NaN
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110034#
name: retinol isomerase (9-cis)
product: MODEL1310110034#
reactant: MODEL1310110034#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110034#_f4040362_9774_418e_8664_aee6b4cf6a48
name: PIGP
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51227
initial concentration: NaN
constant: false
initial amount: NaN

metaM Tn antigen g
has only substance units: false
is: C04383
is: SBO:0000247
name: Tn antigen
type: Species
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_c859ed3f_381d_4bd1_bd1a_455a3b37a96d
name: A4GNT
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q9UNA3
is: SBO:0000252
is encoded by: hsa:51146
constant: false
initial amount: NaN

metaM c3dc e
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H16NO6 CHARGE: -1
is: HMDB02095
has only substance units: false
name: malonyl carnitine
boundary condition: false

metaM HC02180 e
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: thromboxane-b2
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
is: CHEBI:28728

http://identifiers.org/biomodels.db/MODEL1310110034#_2d294da7_3efb_4fd0_bf64_a2182c071d59
name: NDUFB1
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4707
is: O75438
initial amount: NaN

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM 3aib D c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
is: C03265
constant: false
name: D-3-Amino-isobutanoate
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB02299
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_f8767931_2648_4563_a8eb_dbdd9a930f0a
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6584
name: SLC22A5
is: SBO:0000252
constant: false
is: O76082
type: Species

http://identifiers.org/biomodels.db/MODEL1310110034#_e371b211_9d70_4df4_ae47_9a1b9883ef38
type: Species
is encoded by: hsa:27115
name: PDE7B
is: Q9NP56
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM 4hglusa m
constant: false
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_1c91a1e8_7d40_4e87_a66b_d5b6f0524617
initial concentration: NaN
has only substance units: false
name: ALG12
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79087
is: Q9BV10

http://identifiers.org/biomodels.db/MODEL1310110034#_892a7529_b1ab_4a33_b8e1_afb93a48f32e
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: OGDHL
type: Species
boundary condition: true
is: Q9ULD0
is encoded by: hsa:55753

metaM thcholstoic x
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:18402
has only substance units: false
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
is: SBO:0000247
is: HMDB02084
boundary condition: false
initial amount: NaN
has only substance units: false
name: hydrogen cyanide
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110034#_e801dd53_ba1d_4fa2_b272_32bce0bd0eb6
is encoded by: hsa:6513
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC2A1
initial concentration: NaN
is: P11166
constant: false

metaM crn e
initial concentration: 1.0
is: CHEBI:16347
initial amount: NaN
type: Species
is: C00318
name: L-Carnitine
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: SBO:0000247
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110034#_19ec947c_a0e5_4baf_8083_3ae0ef21d0d9
name: SLC2A4
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6517
is: P14672

http://identifiers.org/biomodels.db/MODEL1310110034#_b97ef403_c051_42a5_8c64_8faa5571fd02
initial concentration: NaN
is encoded by: hsa:4724
name: NDUFS4
initial amount: NaN
constant: false
boundary condition: true
is: O43181
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_b28d1179_6414_4923_ba65_6835ace1d5c7
is: P20674
initial concentration: NaN
is encoded by: hsa:9377
is: SBO:0000252
name: COX5A
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM 3aib D e
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
constant: false
has only substance units: false
name: D-3-Amino-isobutanoate
is: SBO:0000247
type: Species
is: HMDB02299
initial amount: NaN
initial concentration: 1.0

metaR 34DHXMANDACOX
kinetic law: MODEL1310110034#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110034#
product: MODEL1310110034#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
reactant: MODEL1310110034#

metaR NACHEX22ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110034#
product: MODEL1310110034#
reversible: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_747f5a2a_faac_4464_a71f_e24d66bded3c
constant: false
is: B3KT86
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: ADCY3
is encoded by: hsa:109
initial concentration: NaN
has only substance units: false

metaR FUCFUCGALACGLCGALGLUSIDEte
reversible: true
is: SBO:0000185
name: blood group intracellular transport
reactant: MODEL1310110034#
product: MODEL1310110034#
fast: false
kinetic law: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110034#_206529f0_e34b_4dd4_816d_72edb199a4d9
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: PRDX2
is encoded by: hsa:7001

metaR GALASE13ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110034#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110034#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110034#

metaM Tn antigen l
is: C04383
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: Tn antigen
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false

metaM 5aop c
constant: false
is: SBO:0000247
is: HMDB01149
is: C00430
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: CHEBI:17549
initial concentration: 1.0
type: Species
name: 5-Amino-4-oxopentanoate
initial amount: NaN

metaR CYSt4
reactant: MODEL1310110034#
is: SBO:0000185
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
name: L-cysteine reversible transport via sodium symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110034#

http://identifiers.org/biomodels.db/MODEL1310110034#_6e68dce1_b4a7_4960_8183_f6aee9481d44
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:175
name: AGA
is: P20933
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaM ncam e
constant: false
initial concentration: 1.0
is: CHEBI:0
has only substance units: false
is: HMDB01406
is: C00153
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Nicotinamide

metaM 12ppd R c
name: (R)-propane-1,2-diol
has only substance units: false
is: HMDB01881
is: CHEBI:28972
type: Species
boundary condition: false
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110034#_ee921328_ab2a_41b3_bdc1_2bebfb4b6fb1
name: GGT2
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:728441
type: Species

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110034#
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM cyan e
is: CHEBI:18407
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
is: HMDB02084
boundary condition: false
constant: false
has only substance units: false
type: Species
name: hydrogen cyanide
initial concentration: 1.0

metaR C10DCCACT
kinetic law: MODEL1310110034#
product: MODEL1310110034#
reactant: MODEL1310110034#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaM crn c
initial concentration: 1.0
is: HMDB00062
constant: false
is: SBO:0000247
is: CHEBI:16347
initial amount: NaN
type: Species
name: L-Carnitine
boundary condition: false
has only substance units: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110034#_5755be02_e38d_4e4c_affc_b966f6e47788
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: B4DER4
name: PIK3CB
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5291
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_43e0f518_9f9d_497c_8a99_3bea2ccede31
is: SBO:0000252
is: Q969X2
is encoded by: hsa:30815
has only substance units: false
constant: false
name: ST6GALNAC6
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR GK1
modifier: MODEL1310110034#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
kinetic law: MODEL1310110034#
product: MODEL1310110034#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
reversible: true

metaR PCHOLP hs
is: SBO:0000176
fast: false
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110034#
is described by: ECO:0000269
name: choline phosphatase
type: Reaction
reactant: MODEL1310110034#
reversible: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ

metaM cholcoa c
initial concentration: 1.0
is: HMDB01374
type: Species
initial amount: NaN
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
is: CHEBI:57373
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_1ad950af_8662_4d1f_9f00_f8c839c9f1ef
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q6FH11
has only substance units: false
name: HMOX1
is encoded by: hsa:3162
is: SBO:0000252

metaR r0236
reversible: true
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000176
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110034#
kinetic law: MODEL1310110034#
modifier: MODEL1310110034#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction

metaR 3HKYNAKGAT
is: SBO:0000176
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
type: Reaction
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

http://identifiers.org/biomodels.db/MODEL1310110034#_337b59db_64ec_42ba_b5a5_966900867329
boundary condition: true
is: O43674
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4711
name: NDUFB5
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_2bd66bc0_240c_4233_a0ae_c0964a01e75b
name: ENTPD1
is: Q86VV3
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:953
initial concentration: NaN
type: Species

metaR CITL
is: SBO:0000176
type: Reaction
modifier: MODEL1310110034#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is described by: ECO:0000000
fast: false
reactant: MODEL1310110034#
reversible: false
product: MODEL1310110034#
kinetic law: MODEL1310110034#
name: Citrate lyase

http://identifiers.org/biomodels.db/MODEL1310110034#_e378aeed_faca_4ac0_a88e_7052491240c1
is encoded by: hsa:5167
type: Species
initial amount: NaN
is: SBO:0000252
is: P22413
initial concentration: NaN
constant: false
name: ENPP1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110034#_1c52d978_9b9d_4605_93c1_21a4a7deabb6
initial concentration: NaN
constant: false
name: SLC22A2
type: Species
boundary condition: true
is encoded by: hsa:6582
is: O15244
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110034#_16dc1f4b_c3c5_40ad_a8c6_a86b2390fabf
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:57419
constant: false
name: SLC24A3
is: SBO:0000252
is: Q9HC58
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_cbe458a2_94ca_46db_a19f_ebc78b8f5b37
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2747
is: SBO:0000252
is: P49448
name: GLUD2

metaR CYSTA
reversible: true
type: Reaction
kinetic law: MODEL1310110034#
name: cysteine transaminase
modifier: MODEL1310110034#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reactant: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110034#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110034#_651742f5_f9d3_4213_98ae_e13216219768
is: SBO:0000252
initial concentration: NaN
is: P51648
has only substance units: false
initial amount: NaN
type: Species
name: ALDH3A2
boundary condition: true
constant: false
is encoded by: hsa:224

metaR UAGDP
reactant: MODEL1310110034#
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
kinetic law: MODEL1310110034#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110034#
is described by: ECO:0000269
product: MODEL1310110034#
is version of: http://identifiers.org/ec-code/2.7.7.23
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110034#_73032d75_80f7_430e_b2ba_5f05d0164d77
is encoded by: hsa:3420
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: IDH3B
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_a3efc5d8_22b1_4903_96af_3570722b11f9
constant: false
has only substance units: false
is: Q11201
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: ST3GAL1
is encoded by: hsa:6482

http://identifiers.org/biomodels.db/MODEL1310110034#_2cc0f7b5_3274_492b_a5c8_bd87521bb011
is: SBO:0000252
is: Q9HAB8
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PPCS
type: Species
boundary condition: true
is encoded by: hsa:79717
constant: false

http://identifiers.org/biomodels.db/MODEL1310110034#_ab41bdc9_effe_46b5_9ede_9d0000739e19
is: P04183
name: TK1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7083
constant: false
has only substance units: false
initial amount: NaN

metaR PRFGS
product: MODEL1310110034#
reactant: MODEL1310110034#
reversible: false
modifier: MODEL1310110034#
is version of: http://identifiers.org/ec-code/6.3.5.3
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110034#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylformylglycinamidine synthase

metaR IDOAASE1ly
reactant: MODEL1310110034#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
reversible: false
name: alpha-L-iduronidase, lysosomal
fast: false
modifier: MODEL1310110034#
is described by: ECO:0000000
product: MODEL1310110034#
is: SBO:0000176
kinetic law: MODEL1310110034#
is version of: http://identifiers.org/ec-code/3.2.1.76

metaM dsT antigen g
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: HMDB01440
boundary condition: false
constant: false
name: disialyl-T antigen
is: CHEBI:16497
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_c29300fb_2d70_419e_93a2_0497e1f312db
boundary condition: true
type: Species
is: SBO:0000297
is encoded by: hsa:522
has part: Q6IB54
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110034#_692da34f_dcd0_41f3_8565_bee875587ad0
is encoded by: hsa:11136
boundary condition: true
has only substance units: false
name: SLC7A9
is: P82251
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110034#_ee84c964_6142_49bc_bf5d_f8f56d76053a
constant: false
name: MTHFD2L
boundary condition: true
is encoded by: hsa:441024
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q9H903
initial amount: NaN

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston