metaM 3mob e
has only substance units: false
boundary condition: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: HMDB00019
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: CHEBI:11851

metaR UDPGLCAter
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
fast: false
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#

metaR ACCOALm
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110032#
type: Reaction
name: acetate-CoA ligase (AMP-forming)

metaR r0853
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reversible: false
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#

metaR r1665
is described by: ECO:0000000
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_7af5cd0f_df1d_477e_88b2_33fe1db0503e
initial concentration: NaN
name: HSD17B4
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:3295
initial amount: NaN
is: E9PB82

metaM tchola e
constant: false
initial amount: NaN
is: HMDB00036
name: taurocholic acid
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR NH4t3r
modifier: MODEL1310110032#
name: ammonia transport via proton antiport
fast: false
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is described by: ECO:0000269
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction

metaR r1915
reversible: false
modifier: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110032#

metaR D 3AIBt
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110032#
name: D-3-amino-isobutyrate transport
kinetic law: MODEL1310110032#
fast: false

metaM dadp n
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
constant: false
is: CHEBI:57667
boundary condition: false
initial concentration: 1.0
is: HMDB01508
has only substance units: false
initial amount: NaN
name: dADP(3-)
is: SBO:0000247

metaM dcmp c
has only substance units: false
is: C00239
initial concentration: 1.0
name: dCMP
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
type: Species
constant: false
is: CHEBI:57566
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0149
reactant: MODEL1310110032#
is described by: ECO:0000000
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110032#

metaM ivcoa m
name: Isovaleryl-CoA
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57345
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: HMDB01113

metaR MAL Ltx
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
fast: false
name: Transport reaction for malate
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_d9c880e1_f990_4b13_94cb_20ac2bf9d26e
initial concentration: NaN
name: GALNT4
boundary condition: true
is encoded by: hsa:8693
type: Species
has only substance units: false
initial amount: NaN
is: Q8N4A0
is: SBO:0000252
constant: false

metaR r2373
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR SPMTDe
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
name: SPMTDe
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
fast: false

metaR PUNP7
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176
fast: false

metaR ALADGLNexR
reversible: true
modifier: MODEL1310110032#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8aaee421_cb99_4a1f_856d_00cb83357f44
initial concentration: NaN
has only substance units: false
name: OGDH
constant: false
boundary condition: true
type: Species
is: Q02218
is: SBO:0000252
is encoded by: hsa:4967
initial amount: NaN

metaR r2443
reversible: false
fast: false
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_4732d3df_06be_4cc4_9aaf_2e002a967410
is: SBO:0000252
initial concentration: NaN
name: CA6
has only substance units: false
constant: false
boundary condition: true
is: Q5FC00
initial amount: NaN
is encoded by: hsa:765
type: Species

metaR PSFLIPm
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.3.1
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
name: phosphatidylserine flippase
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_9940bc50_551e_4d7d_be70_8dcc77d8d36c
type: Species
constant: false
name: GPX6
initial amount: NaN
is encoded by: hsa:257202
boundary condition: true
initial concentration: NaN
is: P59796
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_337618fb_6f12_4075_9b9f_cd9bc8764076
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P15289
is encoded by: hsa:410
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: ARSA

metaR GALASE7ly
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
product: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_dd115e12_d644_4591_a10f_78bdbab91559
initial concentration: NaN
type: Species
boundary condition: true
name: _D87002_1_e
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:D87002

metaM arab L c
is: CHEBI:30849
constant: false
has only substance units: false
is: HMDB00646
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0
is: SBO:0000247
name: L-arabinose

metaM ksi deg23 l
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00143
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 23
initial amount: NaN
type: Species
notes: FORMULA: C124H201N8O106S5 CHARGE: -5

metaR r1664
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000

metaR r2506
name: Utilized transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
fast: false
name: bilirubin transport via bicarbonate countertransport

metaM CE2433 m
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
type: Species
initial amount: NaN
is: CHEBI:57795
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaM dudp n
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
name: dUDP(3-)
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:60471
is: HMDB01000
initial concentration: 1.0

metaM xol7ah2al c
is: SBO:0000247
is: CHEBI:27428
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: HMDB06894
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

http://identifiers.org/biomodels.db/MODEL1310110032#_42e89c59_de8c_49fd_bce9_edd1d50d5282
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q6ZWP6
name: ACAD8
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:27034

metaR CDS
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.7.41
name: phosphatidate cytidylyltransferase
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
product: MODEL1310110032#
type: Reaction

metaM dadp m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: dADP(3-)
type: Species
constant: false
is: CHEBI:57667
is: HMDB01508
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN

metaR RE0691C
name: RE0691
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110032#

metaR PUNP6
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyinosine)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#

metaR r2374
is: SBO:0000185
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM 5mthf c
type: Species
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
has only substance units: false
is: C00440
constant: false
is: HMDB01396
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
boundary condition: false
is: SBO:0000247

metaM CE2705 n
name: quinonoid dihydrobiopterin
boundary condition: false
is: HMDB02281
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15374
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_e7746553_e39a_46db_a35c_095bf99cd122
is: SBO:0000252
is encoded by: hsa:35
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P16219
name: ACADS
boundary condition: true
type: Species

metaM dgchol c
is: HMDB00637
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: glycochenodeoxycholate
constant: false
type: Species
has only substance units: false

metaM 2425dhvitd3 m
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:28818
type: Species
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337
name: (24R)-24,25-dihydroxycalciol
initial amount: NaN

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3e04bdf9_1293_43b3_b131_59c685b8ff99
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8527
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: DGKD

http://identifiers.org/biomodels.db/MODEL1310110032#_e5d973e4_2d86_4e10_8faa_ee3529dbc52c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26289
constant: false
type: Species
name: AK5

metaR PI4PP
name: phosphatidylinositol-4-phosphate 4-phosphatase
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
fast: false

metaR 24 25DHVITD3tm
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110032#
name: 24,25-Dihydroxyvitamin D3 transport from mitochondria

metaR r1667
reversible: true
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000

metaM itaccoa m
constant: false
is: SBO:0000247
is: CHEBI:57381
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: itaconyl-CoA(5-)
is: HMDB03377

metaM aps c
initial amount: NaN
is: CHEBI:58243
is: SBO:0000247
constant: false
is: HMDB01003
has only substance units: false
name: 5'-adenylyl sulfate(2-)
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
boundary condition: false

metaM dudp m
boundary condition: false
name: dUDP(3-)
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:60471
is: HMDB01000
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5d75bade_e823_4fb5_847d_a84caa3569ca
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P28332
is encoded by: hsa:130
name: ADH6
is: SBO:0000252
type: Species

metaR r2375
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
fast: false

metaR PUNP5
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
kinetic law: MODEL1310110032#
type: Reaction
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_78d5e00b_0558_43c1_b51b_dae43dd66cdc
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2653
constant: false
name: GCSH
is: P23434
initial amount: NaN

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_ed65136c_8579_405e_91d9_2a5ceea17354
has only substance units: false
is: Q99755
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: PIP5K1A
initial concentration: NaN
is encoded by: hsa:8394

metaR RPI
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110032#
name: ribose-5-phosphate isomerase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.3.1.6
modifier: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_a9fc4b68_4b8d_42ac_a786_07ae589b9636
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:23530
name: NNT
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r1666
reversible: true
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#

metaM arab L e
type: Species
is: SBO:0000247
is: HMDB00646
initial amount: NaN
name: L-arabinose
boundary condition: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
is: CHEBI:30849
has only substance units: false

metaR ASCBt4
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
reactant: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_9561e401_d010_4334_ab87_706148a68840
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: A0S0A7
name: NOS3
initial amount: NaN
is encoded by: hsa:4846
type: Species

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
fast: false
name: Sulfate transport (lysosome)
is: SBO:0000185
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true

metaR ETFQO
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.5.1
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977

metaR RE2814M
name: RE2814
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
product: MODEL1310110032#
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_22e7e53c_122d_4832_9147_f88a296d8950
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:10723
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9Y666
name: SLC12A7

metaR GLYCt
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
name: glycerol transport via channel
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_cbaed0a3_e55a_43a2_adad_3fdcdf845d0a
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:6799
name: SULT1A2
type: Species
initial concentration: NaN
is: SBO:0000252

metaR RE1523M
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1523
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110032#
type: Reaction
reversible: true

metaR PUNP4
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110032#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is described by: ECO:0000269
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_31378587_e5ba_4d36_bef0_eb2a3418f4a9
name: ZADH2
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:284273
is: SBO:0000252
has only substance units: false
is: Q4G1C4
initial amount: NaN
constant: false

metaM Rtotal3coa c
is: HMDB01448
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16189
name: R total 3 Coenzyme A
boundary condition: false
type: Species
constant: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4

metaR r2376
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM gly m
initial concentration: 1.0
boundary condition: false
type: Species
is: C00037
has only substance units: false
is: CHEBI:15428
is: HMDB00123
initial amount: NaN
is: SBO:0000247
name: Glycine
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

metaM paps g
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58339
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110032#_79f3602e_e0c5_446b_99a1_c8dca81c0335
initial amount: NaN
name: SLC25A1
is: SBO:0000252
constant: false
is: D9HTE9
type: Species
is encoded by: hsa:6576
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM 3ohdcoa x
type: Species
initial amount: NaN
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06402

metaR FAOXC183806m
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#

metaM gthox c
is: CHEBI:58297
has only substance units: false
name: Oxidized glutathione
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species
is: C00127
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB03337
initial concentration: 1.0

metaR FUMtm
kinetic law: MODEL1310110032#
name: fumarate transport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is: SBO:0000185
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_89f474af_51cb_4575_a2fc_51e3df98f1a2
initial concentration: NaN
type: Species
name: _BE966236_1_m
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BE966236

http://identifiers.org/biomodels.db/MODEL1310110032#_3785fcb6_3a49_4436_bb4c_b27a3ad93644
is encoded by: hsa:160728
name: SLC5A8
boundary condition: true
constant: false
is: Q8N695
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r2509
name: Utilized transport
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_b6792490_9e40_4853_9ea8_1fefa1754323
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1215
initial concentration: NaN
name: CMA1
initial amount: NaN
type: Species
constant: false
is: Q4FEB3
has only substance units: false

metaM gln L e
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:18050
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00641
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247

metaM HC02179 e
type: Species
constant: false
is: SBO:0000247
name: 20-hydroxy-arachidonate
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN
is: CHEBI:34306

metaM dgsn c
is: HMDB00085
name: Deoxyguanosine
is: C00330
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
is: CHEBI:17172

http://identifiers.org/biomodels.db/MODEL1310110032#_741377b6_4af6_4441_9b1e_abd62f2c47d4
initial amount: NaN
name: B3GALT5
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10317
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_a2cd1afa_199f_4371_88af_23858a268c31
is: Q9NNW7
type: Species
constant: false
is encoded by: hsa:10587
is: SBO:0000252
initial amount: NaN
name: TXNRD2
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r1661
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
product: MODEL1310110032#

metaR UMPK3
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110032#
name: UMP kinase (UTP)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true

metaR ADK3
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
product: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
name: adentylate kinase (GTP)
type: Reaction

metaR RAI2
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is: SBO:0000176
name: retinal isomerase (9-cis)
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaR CYOOm3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
reversible: false
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
name: cytochrome c oxidase, mitochondrial Complex IV
kinetic law: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8d87c305_c3a9_46c4_92d2_715977c01838
is: P33316
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1854
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: DUT

http://identifiers.org/biomodels.db/MODEL1310110032#_011bb13b_9306_4104_aa39_2de59c611c0e
is: SBO:0000252
is: P49327
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2194
boundary condition: true
name: FASN

metaR RE2814R
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
name: RE2814
reactant: MODEL1310110032#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_2fc30b0e_e2a9_4598_b4cd_545569578dba
is encoded by: hsa:AI631997
boundary condition: true
constant: false
name: _AI631997_1_m
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM dump c
is: CHEBI:246422
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
is: HMDB01409
is: C00365
name: dUMP
has only substance units: false

metaR BTNt2
reactant: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110032#
type: Reaction
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000185
name: Biotin reversible transport via proton symport

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR VITD3t2
is described by: ECO:0000000
product: MODEL1310110032#
name: Vitamin D3 uptake
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
type: Reaction

metaM HC02187 c
type: Species
initial amount: NaN
name: reverse-triiodthyronine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28774
has only substance units: false
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR GDPFUCtg
reactant: MODEL1310110032#
is: SBO:0000185
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
kinetic law: MODEL1310110032#
name: GDPFuc Golgi transport via CMP antiport
reversible: true

metaR BACCLm
is described by: ECO:0000254
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
reactant: MODEL1310110032#
fast: false
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110032#_8ad9669e_79e6_49c8_98bb_f55f90eb173b
is encoded by: hsa:8776
initial concentration: NaN
name: MTMR1
is: Q13613
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
name: 9-cis-retinol
is: HMDB06217
is: CHEBI:17336
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR RE1525M
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE1525
is described by: ECO:0000000

metaR r1886
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110032#

metaR NTD7e
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: 5'-nucleotidase (AMP), extracellular
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM dhap m
is: HMDB01473
type: Species
is: C00111
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
is: SBO:0000247
name: Dihydroxyacetone phosphate
constant: false
initial amount: NaN

metaR UMPK4
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110032#
name: UMP kinase (GTP)
kinetic law: MODEL1310110032#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#

metaR r1660
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ed9e1724_7054_4f52_a8e5_39dc27f25130
type: Species
initial concentration: NaN
name: SDHD
is encoded by: hsa:6392
initial amount: NaN
constant: false
is: O14521
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM 2maacoa m
initial amount: NaN
is: HMDB01157
is: CHEBI:57335
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344

http://identifiers.org/biomodels.db/MODEL1310110032#_64d2d221_34d2_487a_abba_05ce19f1d9d5
type: Species
name: NT5C2
is: SBO:0000252
is encoded by: hsa:22978
boundary condition: true
is: P49902
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaR GLUt2m
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: L-glutamate reversible transport via proton symport, mitochondrial
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaM glyc R m
constant: false
has only substance units: false
is: CHEBI:16659
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: D-glycerate
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaM pan4p e
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2
type: Species
constant: false
is: SBO:0000247
is: HMDB01416
is: C01134
has only substance units: false
name: Pantetheine 4'-phosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM leuktrF4 e
has only substance units: false
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB06465
type: Species
is: CHEBI:27491
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_28002a5b_4b0d_425e_b8d0_c72908204ae9
initial concentration: NaN
is encoded by: hsa:222
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: P48448
boundary condition: true
name: ALDH3B2

metaR ADRNCOAtx
type: Reaction
kinetic law: MODEL1310110032#
fast: false
name: fatty acid intracellular transport
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
reversible: true

metaR INSTt4
kinetic law: MODEL1310110032#
reversible: true
name: inositol transport via sodium symport
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b5707e87_7e55_4f1d_8f83_e57611a30e28
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: ACAT2
initial amount: NaN
is encoded by: hsa:39
is: Q9BWD1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_c94006f4_e27c_4b98_8e8f_6eefe2946963
is: O76082
name: SLC22A5
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6584
initial concentration: NaN
has only substance units: false

metaR r2507
name: Utilized transport
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_bc3840b1_75ec_4dc2_a40c_a1c2f4ac3c36
constant: false
name: GUK1
is encoded by: hsa:2987
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q16774
initial amount: NaN
boundary condition: true
has only substance units: false

metaM tchola c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
is: HMDB00036
initial concentration: 1.0
type: Species
constant: false
name: taurocholic acid
boundary condition: false
is: CHEBI:36257

metaM HC02179 c
is: CHEBI:34306
name: 20-hydroxy-arachidonate
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN

metaR UMPK5
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_76c99e39_9b37_4d74_bed0_cbf9c4d749d2
is encoded by: hsa:AI620219
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI620219_1_m
has only substance units: false

metaR ADK1
type: Reaction
name: adenylate kinase
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR ORPT
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
reversible: true
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: orotate phosphoribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110032#

metaR CERT2rt
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
name: ceramide transport protein
type: Reaction
is: SBO:0000185

metaR r2371
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR CORE6GTg
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_74925650_bb1d_4005_9ed7_6bba7e36fa51
is encoded by: hsa:10005
is: SBO:0000252
is: O14734
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: ACOT8
type: Species

metaR G6Pter
reversible: true
modifier: MODEL1310110032#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaR PRISTCOAtcx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_490238a8_0222_4328_b25d_6d5d532748ca
name: NDUFB7
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P17568
is encoded by: hsa:4713
boundary condition: true

metaR r1708
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR THMP
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
type: Reaction
name: thiamin phosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD

metaR UMPK7
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110032#
name: UMP kinase (dGTP)
modifier: MODEL1310110032#
reversible: true
is: SBO:0000176
type: Reaction

metaM s2l2n2m2m l
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
name: de-Fuc form of PA6 (w/o peptide linkage)
initial amount: NaN
is: CHEBI:57312
initial concentration: 1.0
is: HMDB01356
constant: false
is: SBO:0000247
type: Species
boundary condition: false

metaM leuktrF4 c
is: SBO:0000247
is: HMDB06465
type: Species
boundary condition: false
is: CHEBI:27491
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
constant: false
name: leukotriene F4
initial concentration: 1.0

metaM pan4p c
is: CHEBI:47942
type: Species
has only substance units: false
name: Pantetheine 4'-phosphate
constant: false
initial concentration: 1.0
boundary condition: false
is: C01134
is: SBO:0000247
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN

metaR UMPK6
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#

metaR r1662
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110032#

metaM 5mthf e
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
name: 5-Methyltetrahydrofolate
boundary condition: false
constant: false
is: HMDB01396
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:3729
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_e3d8c652_5b1a_417d_b798_bdd9bafb9b6e
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:100128062
is: SBO:0000252
constant: false
name: _100128062_1_m
initial concentration: NaN
initial amount: NaN

metaR DNDPt40m
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
name: dUTP transport via dADP antiport
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_484164bc_fd8c_4503_994e_30d79721c4f0
initial amount: NaN
is encoded by: hsa:9517
name: SPTLC1:SPTLC2
is encoded by: hsa:10558
is: SBO:0000297
type: Species
boundary condition: true
constant: false
has part: O15269
has part: O15270
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ce1b0132_3443_436d_abb4_905c1262b06a
initial amount: NaN
name: _AA854479_1_m
type: Species
has only substance units: false
is encoded by: hsa:AA854479
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaR AATAi
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: 2-aminoadipate transaminase, irreversible
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM

metaR r1552
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM forglu c
boundary condition: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: C00439
constant: false
is: CHEBI:18327
has only substance units: false
type: Species
is: SBO:0000247
name: N-Formimidoyl-L-glutamate
is: HMDB00854
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_71a7f0c2_ff1d_49aa_bee3_3f26f8fa5ed3
type: Species
constant: false
is: O00462
is encoded by: hsa:4126
boundary condition: true
has only substance units: false
name: MANBA
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_4ec0dbbb_5a53_4780_a810_b588c31c0ef0
initial amount: NaN
name: SKIV2L2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q3MHC9
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23517

metaR NACHEXA18ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110032#
modifier: MODEL1310110032#

metaM datp m
has only substance units: false
is: CHEBI:61404
is: SBO:0000247
constant: false
boundary condition: false
is: C00131
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
name: dATP
is: HMDB01532
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ec34327f_69b3_496e_af98_f0725e9163db
is: Q92820
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8836
constant: false
name: GGH
initial concentration: NaN
type: Species
has only substance units: false

metaR r0911
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110032#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e0e3474f_8faa_4554_8a7a_2510c27d175a
type: Species
boundary condition: true
has only substance units: false
name: UEVLD
is: Q8IX04
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55293

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM HC02202 e
type: Species
initial concentration: 1.0
is: CHEBI:57398
is: SBO:0000247
name: prostaglandin A1(1-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

metaM 2425dhvitd3 e
is: CHEBI:28818
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337
initial amount: NaN
constant: false
name: (24R)-24,25-dihydroxycalciol
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM HC01444 e
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
boundary condition: false
is: CHEBI:15754
name: Galactosylglycerol
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_3992266d_8178_4f85_a32d_8c3e4a4c1443
initial amount: NaN
is: Q9BYZ2
boundary condition: true
initial concentration: NaN
has only substance units: false
name: LDHAL6B
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:92483

metaR r0142
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
type: Reaction
reversible: false

metaR r1551
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HEX7
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000304
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
name: hexokinase (D-fructose:ATP)
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
fast: false
modifier: MODEL1310110032#

metaR NRPPHRSULT
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
name: Norepinephrine Sulfotransferase
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM ksi deg17 l
initial concentration: 1.0
is: HMDB00143
boundary condition: false
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 17
constant: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
type: Species

metaM datp n
initial concentration: 1.0
is: SBO:0000247
constant: false
name: dATP
is: HMDB01532
is: C00131
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
initial amount: NaN
boundary condition: false
has only substance units: false

metaM guln r
type: Species
constant: false
name: L-gulonate
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
is: HMDB03290
initial concentration: 1.0

metaM msa m
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 3-oxopropanoate
is: HMDB11111
is: CHEBI:33190
is: SBO:0000247
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222

metaR r1418
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_a20cdb94_e62e_4433_be38_2af7f3099db2
constant: false
boundary condition: true
is encoded by: hsa:80308
initial amount: NaN
is: Q8NFF5
initial concentration: NaN
type: Species
name: FLAD1
has only substance units: false
is: SBO:0000252

metaM malthx e
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false
is: SBO:0000247
constant: false
is: C01936
boundary condition: false
name: Maltohexaose
type: Species
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041

metaM HC01104 e
initial concentration: 1.0
constant: false
is: CHEBI:61146
type: Species
has only substance units: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
boundary condition: false
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
is: SBO:0000247

metaR ACONTm
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
reversible: true
name: Aconitate hydratase
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction

metaM sgalside hs l
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00904
has only substance units: false
name: sulfatide galactocerebroside
initial amount: NaN
constant: false
is: CHEBI:16349
initial concentration: 1.0

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110032#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
reactant: MODEL1310110032#
is described by: ECO:0000269

metaR 3MOBte
product: MODEL1310110032#
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110032#

metaM udp n
is: HMDB00295
is: CHEBI:58223
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
name: UDP(3-)
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2d3a0306_2f6a_4e09_a104_528b9f5cb3f0
has only substance units: false
initial amount: NaN
name: UMPS
initial concentration: NaN
boundary condition: true
is: A8K5J1
is: SBO:0000252
is encoded by: hsa:7372
type: Species
constant: false

metaR S4TASE2ly
modifier: MODEL1310110032#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
reactant: MODEL1310110032#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12

metaR r1554
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110032#

metaM gln L c
initial amount: NaN
has only substance units: false
type: Species
name: L-glutamine
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
is: HMDB00641
boundary condition: false
is: CHEBI:18050
initial concentration: 1.0

metaR FUMTSULtm
fast: false
name: Fumarate:thiosulfate antiport, mitochondrial
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_29694cf5_d674_4740_a142_cb96e8aa3c22
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: Q9BYC2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: OXCT2
is encoded by: hsa:64064

http://identifiers.org/biomodels.db/MODEL1310110032#_ba48eba4_69a1_4416_ae5e_847353b43ccf
constant: false
initial amount: NaN
is: P26439
is encoded by: hsa:3284
has only substance units: false
name: HSD3B2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0913
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_830c1ac5_7f67_4446_b292_0b76aff98b6f
type: Species
constant: false
is encoded by: hsa:56953
has only substance units: false
is: SBO:0000252
name: NT5M
boundary condition: true
initial amount: NaN
is: Q9NPB1
initial concentration: NaN

metaM HC02202 c
initial amount: NaN
is: CHEBI:57398
name: prostaglandin A1(1-)
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0

metaM mi13p c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
constant: false
is: HMDB06234
is: CHEBI:18225
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_defb367b_8d49_4e70_9b63_ebb0871c987b
has only substance units: false
name: COX8A
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1351
is: SBO:0000252
is: Q53XN1
boundary condition: true
type: Species

metaR GLUDxm
modifier: MODEL1310110032#
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110032#
reversible: true

metaR RTOTAL3FATPc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2d13eb7a_dcbf_4534_8137_b2e890d66e36
initial concentration: NaN
boundary condition: true
name: SULT1A1
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6817
initial amount: NaN

metaM 4izp c
name: 4-Imidazolone-5-propanoate
has only substance units: false
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01014
boundary condition: false
type: Species
is: SBO:0000247

metaR SRTNtu
reversible: true
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
name: Serotonin uniport
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f758fb0f_ed1b_4873_80ad_277b4b4a5449
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:11332
initial concentration: NaN
has only substance units: false
is: O00154
name: ACOT7

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r1553
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM retinal 11 cis c
name: 11-cis-retinal
constant: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02152
type: Species
is: CHEBI:16066
initial amount: NaN

metaM C05957 r
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB02710
is: CHEBI:27485
name: Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial concentration: 1.0
is: SBO:0000247

metaR GLXtm
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
name: glyoxylate transport, mitochondrial
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
type: Reaction

metaR TRIODTHYt2
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: T3 transport via facilitated diffusion

metaM CE2705 c
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:36781
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
has only substance units: false
is: SBO:0000247
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: C00154
is: HMDB01338

metaR RE1518M
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_64bbba65_86ff_4d96_8cfb_500f8e5c7541
initial concentration: NaN
is: Q4KWH8
has only substance units: false
initial amount: NaN
is encoded by: hsa:23007
constant: false
name: PLCH1
type: Species
is: SBO:0000252
boundary condition: true

metaR LTA4H
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.3.2.6
modifier: MODEL1310110032#
name: Leukotriene A-4 hydrolase
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110032#

metaR ACCOACm
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
name: Acetyl-Coa carboxylase, beta isoform
notes: GENE_ASSOCIATION: (32.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.4.1.2 Confidence Level: 4 AUTHORS: PMID:10677481 NOTES:TDV (9/14/2004)
is version of: http://identifiers.org/ec-code/6.4.1.2
is described by: ECO:0000269
modifier: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ad265db0_dcad_45c4_ab13_14580db5ecdf
has only substance units: false
constant: false
is encoded by: hsa:6524
name: SLC5A2
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P31639

metaR HEX4
is: SBO:0000176
reactant: MODEL1310110032#
name: hexokinase (D-mannose:ATP)
is described by: ECO:0000304
kinetic law: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
fast: false
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_841b493d_08e2_4c9c_b4ae_7bb35a2aeece
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: B3KVA3
name: RDH13
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:112724

http://identifiers.org/biomodels.db/MODEL1310110032#_ac8d3729_7b2d_4521_b6e0_ccac49faf51e
is encoded by: hsa:6392
constant: false
type: Species
is: O14521
boundary condition: true
name: SDHD
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR ICDHyrm
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
name: Isocitrate dehydrogenase (NADP+)
type: Reaction

metaM fald c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16842
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
constant: false
has only substance units: false

metaR GALASE8ly
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110032#
reversible: false
type: Reaction
modifier: MODEL1310110032#
name: beta-galactosidase, lysosomal
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR RE0344C
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: RE0344
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is described by: ECO:0000000
is: SBO:0000176

metaR UMPK2n
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
is described by: ECO:0000269
type: Reaction
name: UMP kinase (CTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110032#_8080d3f9_1881_4260_b9d6_d6c6ec76251f
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10965
initial concentration: NaN
is: P49753
type: Species
name: ACOT2

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110032#
fast: false
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110032#

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: phosphatidylethanolamine
is: CHEBI:16038
type: Species
initial amount: NaN

metaR PUNP3
is: SBO:0000176
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r0145
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:

metaR r0915
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1556
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185

metaR GALASE11ly
reactant: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110032#

metaM 6dhf e
is: HMDB06563
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
is: SBO:0000247
name: hexaglutamyl folate (DHF)
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR INSt
is described by: ECO:0000269
reversible: true
product: MODEL1310110032#
name: Inosine transport (diffusion)
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
fast: false
is: SBO:0000185

metaR r0784
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
kinetic law: MODEL1310110032#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110032#
type: Reaction

metaR PUNP2
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110032#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyadenosine)
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR ALADGLYexR
name: D-alanine/glycine reversible exchange
kinetic law: MODEL1310110032#
is described by: ECO:0000304
reversible: true
product: MODEL1310110032#
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110032#

metaR LCADi
modifier: MODEL1310110032#
name: lactaldehyde dehydrogenase
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110032#
is described by: ECO:0000304
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e3448d69_dba1_4594_a442_6c5252871696
constant: false
initial amount: NaN
is: O15056
boundary condition: true
has only substance units: false
type: Species
name: SYNJ2
initial concentration: NaN
is encoded by: hsa:8871
is: SBO:0000252

metaM 3mgcoa m
has only substance units: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
type: Species
is: CHEBI:57346
constant: false
is: HMDB01057
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_20dae7ef_e738_4afd_8941_686462e3d0ca
name: TXNRD2
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:10587
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d975cefc_f746_464b_a229_9610db9f4a42
is: SBO:0000252
constant: false
initial amount: NaN
name: _BC005314_1_x
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:BC005314

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM HC02023 r
type: Species
is: CHEBI:46898
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false
has only substance units: false
initial amount: NaN
name: Cholesterol-ester-ol
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM 2amac c
name: 2-aminoacrylic acid
constant: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
is: HMDB03609
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:17123
type: Species
boundary condition: false

metaR UDPGLCter
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
type: Reaction
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185

metaR r0783
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
type: Reaction
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110032#_1f227699_b798_44a9_bd6a_ad4eae3ede00
is encoded by: hsa:6520
is: P08195
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC3A2
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_95b557e5_3852_444d_afdf_cdce9a57a31f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4694
constant: false
initial amount: NaN
is: Q6IBB5
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFA1

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b0253460_ad22_4d5d_93fb_b746d59911d6
has only substance units: false
type: Species
initial concentration: NaN
name: AHCYL1
is: SBO:0000252
is encoded by: hsa:10768
initial amount: NaN
constant: false
boundary condition: true

metaM maltttr e
name: Maltotetraose
type: Species
is: C02052
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ce6ffffc_b62c_4f57_88d8_c389ad29a925
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:29922
has only substance units: false
type: Species
boundary condition: true
name: NME7

http://identifiers.org/biomodels.db/MODEL1310110032#_86d6ceed_29c4_4782_a4d2_bdda741dedb8
type: Species
constant: false
boundary condition: true
is: Q99519
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: NEU1
is encoded by: hsa:4758
has only substance units: false

metaR DCSPTN1CPT1
kinetic law: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_668744c8_baa6_469f_8c92_eaccab5606e3
has only substance units: false
name: NDUFA2
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: O43678
constant: false
is encoded by: hsa:4695
initial amount: NaN

metaM 3ohdcoa m
initial amount: NaN
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
is: SBO:0000247
type: Species
is: CHEBI:57349
initial concentration: 1.0
constant: false
is: HMDB06402
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r0917
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_eba99eef_fe0a_408a_99f2_d6b560c8d0f3
is: P11310
has only substance units: false
name: ACADM
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:34
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_11dd142a_9fb9_4681_ad83_47a0fbd865d4
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AV713053
name: _AV713053_1_m
is: SBO:0000252

metaM udp r
has only substance units: false
is: C00015
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: UDP
is: HMDB00295
is: CHEBI:58223

metaR RTOTAL2t
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
name: RTOTAL2 transport
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_ac21cc74_cf6d_4626_9f4d_732f98b75cdb
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: ENPP1
is: P22413
constant: false
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110032#_4a34af72_a6a9_473a_9180_9eaba62bac01
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P00813
name: ADA
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:100

metaM 3mob c
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
is: CHEBI:11851
initial amount: NaN
is: HMDB00019
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR CERT2gt
kinetic law: MODEL1310110032#
name: ceramide transport protein
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
reactant: MODEL1310110032#

metaM dhap x
is: C00111
name: Dihydroxyacetone phosphate
is: HMDB01473
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57642
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f4b6dc4c_f476_4d0a_bd30_497e7eb414dd
initial amount: NaN
name: UGT1A8
has only substance units: false
type: Species
is encoded by: hsa:54576
initial concentration: NaN
is: Q5DSZ6
boundary condition: true
constant: false
is: SBO:0000252

metaM dcmp n
is: CHEBI:57566
initial concentration: 1.0
type: Species
name: dCMP(2-)
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01202
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_af0a85af_cf5f_4f66_b54b_f2cc7c0b418c
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:205
name: AK4
type: Species
is: P27144
is: SBO:0000252

metaR GUAt
is: SBO:0000185
is described by: ECO:0000269
name: Guanine transport
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110032#_f0490034_48bd_413b_9020_6c52561631e9
has only substance units: false
is: Q9NRF8
type: Species
is encoded by: hsa:56474
boundary condition: true
name: CTPS2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaM 2425dhvitd3 c
constant: false
name: (24R)-24,25-dihydroxycalciol
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:28818
boundary condition: false
has only substance units: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337

metaR 3DSPHR
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110032#
product: MODEL1310110032#
name: 3-Dehydrosphinganine reductase
is version of: http://identifiers.org/ec-code/1.1.1.102
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#

metaM xol27oh r
type: Species
name: 26-hydroxycholesterol
is: HMDB02103
has only substance units: false
is: CHEBI:17703
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d02a1ab6_c2e1_41df_b4b8_3e4cccf18d5e
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SULT1A1
is encoded by: hsa:6817
type: Species
is: SBO:0000252
constant: false

metaR RE2799C
type: Reaction
fast: false
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:

metaM fald e
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01426
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
name: formaldehyde
constant: false
is: CHEBI:16842
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_a481b783_9e69_463d_9234_e07987444c88
is: Q9UBM1
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10400
initial concentration: NaN
name: PEMT

http://identifiers.org/biomodels.db/MODEL1310110032#_4ae9bf61_e5f2_403d_90a7_c18cf121923f
type: Species
is: Q49AT3
has only substance units: false
is encoded by: hsa:8706
name: B3GALNT1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaR LNLCCRNt
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185
modifier: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
product: MODEL1310110032#
reversible: false

metaM ser D e
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
name: D-serine
type: Species
constant: false
initial amount: NaN
is: HMDB03406
initial concentration: 1.0
is: CHEBI:16523
is: SBO:0000247

metaR PNTOte
kinetic law: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110032#
name: Transport of (R)-Pantothenate
type: Reaction
reversible: true
fast: false
product: MODEL1310110032#

metaR r1557
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_7261f080_262e_434c_921b_05004d9118da
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:R06874
name: _R06874_1_r
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_cc434f04_bac2_45aa_8b82_62501b2d85df
has only substance units: false
is encoded by: hsa:113235
name: SLC46A1
constant: false
type: Species
is: Q96NT5
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r1559
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
product: MODEL1310110032#

metaR r0787
type: Reaction
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
product: MODEL1310110032#

metaR RE3565C
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
type: Reaction
reactant: MODEL1310110032#
name: RE3565
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_06f81a66_b58f_4493_befc_6f0bf24481d2
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: PNPO
is: Q9NVS9
is encoded by: hsa:55163
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_3d9cacf5_4d5e_4ec6_92af_120cf8fa90df
is: B2RBR4
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC20A2
has only substance units: false
constant: false
is encoded by: hsa:6575

metaR CHSTEROLt3
product: MODEL1310110032#
name: cholesterol intracellular transport
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction

metaM ser D c
name: D-serine
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
is: HMDB03406
has only substance units: false

metaR r0360
kinetic law: MODEL1310110032#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
is described by: ECO:0000000
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR DCSPTN1CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: carnitine transferase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110032#

metaM pe hs m
name: phosphatidylethanolamine
type: Species
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16038
constant: false
initial amount: NaN

metaM 5HPET c
type: Species
is: CHEBI:57450
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01193
has only substance units: false
name: 5(S)-HPETE(1-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_c0183bed_81ba_4495_bd88_6fadb36d40f9
constant: false
is encoded by: hsa:8875
initial concentration: NaN
name: VNN2
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: A8K7W0

metaR OCCOAtm
is: SBO:0000185
name: Octanoyl-CoA transport, diffusion
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
reversible: false

metaM man c
name: D-Mannose
initial concentration: 1.0
constant: false
is: CHEBI:16024
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ef48bf41_2d71_44ef_81b7_170d0ffc2b38
initial concentration: NaN
is encoded by: hsa:48
constant: false
is: SBO:0000252
initial amount: NaN
is: P21399
has only substance units: false
name: ACO1
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_b40edcda_a7f1_43ed_bb1b_c36c06c01b66
name: LEFTY1
initial concentration: NaN
is: O75610
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10637

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_86717732_7266_41a2_bd8c_352d0d87b91f
is encoded by: hsa:4713
has only substance units: false
name: NDUFB7
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P17568
constant: false
type: Species
initial concentration: NaN

metaM pmtcoa m
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
is: HMDB01338
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00154

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR r0788
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110032#
type: Reaction
reversible: true

metaM ksi deg21 l
boundary condition: false
name: keratan sulfate I, degradation product 21
constant: false
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
is: HMDB00143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_7e7d67ef_5b31_453c_914c_0e346a26dc85
is: P20674
is encoded by: hsa:9377
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: COX5A

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_458265b8_f434_43c3_a53c_46b800fae4ee
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2710
name: GK
is: B4DH54
initial concentration: NaN
initial amount: NaN

metaM prostge1 e
is: CHEBI:57397
constant: false
name: prostaglandin E1(1-)
is: SBO:0000247
type: Species
is: HMDB01442
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaM idour c
name: L-iduronate
is: CHEBI:21338
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR CATm
fast: false
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
reversible: false
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
name: catalase
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.6
reactant: MODEL1310110032#
is: SBO:0000176

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: D-glucuronate
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM prostgf2 e
constant: false
initial amount: NaN
boundary condition: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
initial concentration: 1.0
type: Species
is: CHEBI:57404

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR LINKDEG2ly
fast: false
is described by: ECO:0000000
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_44d61fc0_a7d7_4744_bca7_40f28b561443
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2819
constant: false
has only substance units: false
is: F8W1L5
name: GPD1

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b4036a1b_d2d0_4ce1_b97d_664384154d52
boundary condition: true
type: Species
is: Q59F77
initial amount: NaN
name: PLCB2
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5330

metaR r0596
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_43e19aaf_4fb1_4593_9c52_e3c37ac87ef4
is: SBO:0000252
boundary condition: true
type: Species
name: SLC7A7
is encoded by: hsa:9056
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9UM01
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_468b5950_8db8_43e9_a069_1bc53efe41f0
type: Species
has only substance units: false
is: Q8IV97
name: SLC7A5
is encoded by: hsa:8140
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM akg m
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: C00026
name: 2-Oxoglutarate
is: CHEBI:16810
initial concentration: 1.0
initial amount: NaN

metaR NOt
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185
name: NO transport (diffusion)
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2c84077f_35eb_4e73_96e6_1c78b8e0c1d6
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: PEMT
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10400

metaR ADAe
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: Adenosine deaminase, extracellular
fast: false
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6337e482_5a20_48fe_b8ba_4a2389a8f3da
initial amount: NaN
is encoded by: hsa:AI469183
constant: false
has only substance units: false
initial concentration: NaN
name: _AI469183_1_x
type: Species
boundary condition: true
is: SBO:0000252

metaM man e
initial concentration: 1.0
name: D-Mannose
is: CHEBI:16024
initial amount: NaN
is: HMDB00169
is: C00159
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false
has only substance units: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9695555b_6ca7_465f_b040_53c6514b1692
is encoded by: hsa:23632
initial amount: NaN
has only substance units: false
type: Species
name: CA14
is: A8K3J4
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_34ff204e_c438_4e5f_a5b8_99b86f571c36
initial amount: NaN
has only substance units: false
name: SLC7A6
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9057
constant: false
is: Q92536

metaM L2aadp6sa c
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
name: L-allysine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01263
boundary condition: false
is: CHEBI:17917
initial amount: NaN

metaM hexdiac r
boundary condition: false
initial concentration: 1.0
name: hexadecanediocacid
is: SBO:0000247
type: Species
is: HMDB00672
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
constant: false
has only substance units: false

metaM cl c
initial concentration: 1.0
has only substance units: false
name: Chloride
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:3966
initial amount: NaN
is: C00115
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492

metaM datp c
boundary condition: false
initial concentration: 1.0
is: HMDB01532
is: C00131
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: dATP
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
type: Species

metaM glcur e
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15748
initial amount: NaN
is: SBO:0000247
is: HMDB00127
boundary condition: false

metaR r0022
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_b7c11a79_6a53_477c_a0db_96d7df31456f
name: RRM2
has only substance units: false
is: P31350
is: SBO:0000252
is encoded by: hsa:6241
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaM prostgf2 c
is: CHEBI:57404
boundary condition: false
constant: false
name: prostaglandin F2alpha(1-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
initial concentration: 1.0
is: HMDB01139
type: Species

metaR SERLYSNaex
type: Reaction
is described by: ECO:0000212
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: Serine/Lysine Na-dependent exchange (Ser in)

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR r0638
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR DCSPTN1COAtx
name: fatty acid intracellular transport
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110032#

metaM pep m
is: CHEBI:18021
constant: false
name: Phosphoenolpyruvate
boundary condition: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00263
is: C00074

metaR SO4t4 2
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
type: Reaction
is described by: ECO:0000269
name: sulfate transport via sodium symport
kinetic law: MODEL1310110032#
reversible: true
fast: false
reactant: MODEL1310110032#

metaM tmndnccoa m
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
boundary condition: false
name: timnodonyl coenzyme A
is: HMDB06514

metaR TTDCAtr
name: tetradecanoate (transport)
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
fast: false
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaM adp m
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:456216
boundary condition: false
is: C00008
type: Species
name: ADP
is: HMDB01341

metaR OLEICFATPtc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM sphmyln hs c
boundary condition: false
name: sphmyln_hs[c]
notes: FORMULA: CHARGE: 0
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB02704
initial amount: NaN
has only substance units: false
is: CHEBI:21338

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8ed9ad57_5fb6_4b56_8c67_d6c67b8b0a71
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P07451
name: CA3
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:761

metaR r0021
type: Reaction
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110032#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR FATP3t
type: Reaction
name: fatty acid electroneutral transport
modifier: MODEL1310110032#
reversible: true
is: SBO:0000185
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaM cs b deg2 l
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB00812
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16953
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
constant: false

metaR r0639
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110032#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_c66d8526_c2df_4027_a40f_116372d42567
is: SBO:0000252
is encoded by: hsa:2582
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: GALE
initial concentration: NaN
is: Q14376
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_734002ba_f702_4446_a14a_af3f64c1f97d
type: Species
initial amount: NaN
is encoded by: hsa:7359
is: SBO:0000252
has only substance units: false
constant: false
name: _7359_1_c
initial concentration: NaN
boundary condition: true

metaM fad m
is: SBO:0000247
has only substance units: false
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: HMDB01248
type: Species
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
constant: false
boundary condition: false
is: C00016

http://identifiers.org/biomodels.db/MODEL1310110032#_0c67a851_b7e9_44c0_9ee2_6d64bec60c6e
boundary condition: true
has only substance units: false
initial concentration: NaN
name: OCRL
is encoded by: hsa:4952
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_1ec10f23_4a5b_46b1_a20f_2770931243a9
is encoded by: hsa:4731
initial concentration: NaN
is: P56181
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: NDUFV3
boundary condition: true
has only substance units: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110032#
name: RE0512
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
reversible: true
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaM sarcs m
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00213
is: CHEBI:15611
initial concentration: 1.0
is: HMDB00271
name: Sarcosine

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: HMDB00359
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:16577

metaM bildglcur c
boundary condition: false
is: HMDB03325
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:58471
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
name: bis(beta-glucosyluronate)bilirubin
type: Species
has only substance units: false
constant: false

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM dag hs c
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: CHEBI:18035
name: diglyceride

metaM arachdcoa c
boundary condition: false
initial amount: NaN
is: HMDB06523
is: CHEBI:57368
is: SBO:0000247
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
type: Species

metaM xol27oh m
is: HMDB02103
is: SBO:0000247
boundary condition: false
is: CHEBI:17703
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 26-hydroxycholesterol

metaR r1291
reactant: MODEL1310110032#
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM prostgd2 r
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
has only substance units: false
is: CHEBI:57406
name: prostaglandin D2(1-)
boundary condition: false
is: HMDB01403

http://identifiers.org/biomodels.db/MODEL1310110032#_7a35df1a_c326_47e2_808d_9d318214914d
initial amount: NaN
type: Species
is: P11310
constant: false
is encoded by: hsa:34
initial concentration: NaN
is: SBO:0000252
name: ACADM
boundary condition: true
has only substance units: false

metaM ibcoa m
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01243
is: CHEBI:57338
constant: false
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)
boundary condition: false
initial amount: NaN

metaM dudp c
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C01346
type: Species
is: SBO:0000247
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
is: CHEBI:60471
name: dUDP

http://identifiers.org/biomodels.db/MODEL1310110032#_f4b82fe1_c457_4a3e_b07e_2bc8b1713885
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: P13073
is encoded by: hsa:1327
name: COX4I1

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR ACHtn
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_c1b8fac6_cb05_437e_ab2d_9f2851298bcc
constant: false
initial amount: NaN
initial concentration: NaN
name: ECHS1
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1892
is: P30084

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ba183072_7fe9_4c5a_8924_40af759e1193
is: Q6IBA0
type: Species
constant: false
name: NDUFS5
is encoded by: hsa:4725
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_eb6524fa_1da6_472d_a068_288107a1f7bd
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O00154
type: Species
initial amount: NaN
is encoded by: hsa:11332
initial concentration: NaN
name: ACOT7
constant: false

metaR RETNt
fast: false
name: retinoic acid transport
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_51b11a79_50ab_48e6_92cf_18d22ebacc86
name: UPP1
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:7378
is: SBO:0000252
initial amount: NaN

metaR CYTDtm
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: cytidine facilated transport in mitochondria
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false

metaR DCYTDn
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: deoxycytidine deaminase, nuclear
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a0c7f2ce_4fc5_4bb3_923d_61057fa80e04
is: Q16222
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6675
name: UAP1
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_950d51da_d0db_4844_bfc2_bd26f2f89f15
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:56623
has only substance units: false
constant: false
name: INPP5E
initial amount: NaN
initial concentration: NaN
is: Q9NRR6

metaR DGAT
is described by: ECO:0000000
modifier: MODEL1310110032#
reversible: false
product: MODEL1310110032#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
type: Reaction
name: diacylglycerol acyltransferase
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/2.3.1.20

metaM lald L c
constant: false
type: Species
is: CHEBI:18041
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (S)-lactaldehyde
initial concentration: 1.0
is: HMDB03052

http://identifiers.org/biomodels.db/MODEL1310110032#_c902e888_903f_4db0_bfb1_28456812c11d
initial concentration: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:2108
name: ETFA:ETFB
initial amount: NaN
is encoded by: hsa:2109
has part: P13804
boundary condition: true
type: Species
has only substance units: false

metaR MAN6PI
reversible: true
name: mannose-6-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000304
type: Reaction
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_001f96a6_d6aa_4ab8_8537_5ce12bc1f03c
boundary condition: true
has only substance units: false
is encoded by: hsa:28231
initial concentration: NaN
name: SLCO4A1
type: Species
initial amount: NaN
constant: false
is: Q96BD0
is: SBO:0000252

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_1339f4f3_0287_4c7a_b0cc_85286e051620
name: _AI971036_1_x
boundary condition: true
is encoded by: hsa:AI971036
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_8e3e1312_5fc9_4523_b027_bb4eb89e9408
initial amount: NaN
name: SLC23A2
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9962
type: Species
constant: false
is: SBO:0000252

metaM mal L c
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
name: (S)-malate(2-)
has only substance units: false
is: HMDB00156
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR GLXtp
product: MODEL1310110032#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
name: glyoxylate transport, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110032#_64aa782e_52aa_444c_bf3d_5c3ada19ff03
initial concentration: NaN
name: _LOC728997_1_c
boundary condition: true
is encoded by: hsa:LOC728997
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM adp n
is: HMDB01341
has only substance units: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1812
kinetic law: MODEL1310110032#
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110032#
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r0921
name: Postulated transport reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_96054649_0822_4195_8e37_cf682d8b8c6f
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:60482
is: Q9GZV3
name: SLC5A7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_d76ab02d_d34d_4a4d_8b9e_1483f5077ffd
initial amount: NaN
constant: false
is: O15269
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SPTLC1
is encoded by: hsa:10558
type: Species
is: SBO:0000252

metaM dag hs e
name: diglyceride
initial amount: NaN
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM idour e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02704
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
has only substance units: false
constant: false
is: CHEBI:21338

metaM prostge1 c
initial amount: NaN
is: CHEBI:57397
name: prostaglandin E1(1-)
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01442
has only substance units: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaM bildglcur e
type: Species
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110032#_853b2cd2_0ab7_4d30_b4dc_a857120b990e
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: _HG2846_HT2983_1_m
initial amount: NaN
constant: false
is encoded by: hsa:HG2846-HT2983

metaM glu L m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29985
name: L-glutamate(1-)
constant: false
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_260bf12f_d845_4945_95ba_397ede5d7e92
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:92483
is: SBO:0000252
is: Q9BYZ2
type: Species
name: LDHAL6B
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fa71e10e_9a65_437e_b22d_c358db433223
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9NS82
name: SLC7A10
is encoded by: hsa:56301
type: Species

metaR FRDPtcr
is described by: ECO:0000134
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110032#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.

http://identifiers.org/biomodels.db/MODEL1310110032#_20baef12_0031_4452_84a3_b20fff6e2319
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AV717590
name: _AV717590_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0590
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176

metaM pe hs e
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine
has only substance units: false

metaM arachd c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
is: HMDB01043
constant: false
boundary condition: false
name: arachidonate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_6d3a017f_3f3b_4dc0_8ed6_c5e4007da172
constant: false
type: Species
initial amount: NaN
name: ENTPD3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:956
initial concentration: NaN
is: O75355
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_ca05fdbc_6996_46e1_b3a9_82c4bbe0495c
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: CHAT
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
is: P28329

http://identifiers.org/biomodels.db/MODEL1310110032#_d2ec2f66_8573_4b75_8623_ba02bbe3e512
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:22305
initial amount: NaN
name: _22305_2_c
type: Species

metaR r0634
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110032#
product: MODEL1310110032#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_64f4f7dc_fa15_4e7c_a0b6_b9e7a4d4f1e4
initial concentration: NaN
is: Q8TF08
boundary condition: true
is encoded by: hsa:170712
is: SBO:0000252
name: COX7B2
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM gly c
initial concentration: 1.0
has only substance units: false
type: Species
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: C00037
initial amount: NaN
is: HMDB00123
is: CHEBI:3339
constant: false

metaM fucfucgalacglcgalgluside hs e
is: HMDB00660
boundary condition: false
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
type: Species
is: CHEBI:15824
constant: false
is: SBO:0000247
is: C00095
has only substance units: false
name: Leb glycolipid
initial amount: NaN
initial concentration: 1.0

metaM idour l
boundary condition: false
is: SBO:0000247
is: CHEBI:21338
constant: false
type: Species
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_57d7591a_7a4c_469c_bc55_5af65a09c70e
constant: false
name: SLC22A2
boundary condition: true
is encoded by: hsa:6582
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

MODEL1310110032
species: metaM triodthy c
reaction: metaR EX hxan LPAREN e RPAREN
species: metaM CE2705 n
species: metaM ac m
reaction: metaR EX acmana LPAREN e RPAREN
species: metaM air c
reaction: metaR r1568
reaction: metaR ATPtm
species: metaM galside hs e
reaction: metaR r2389
species: metaM nrpphrsf e
reaction: metaR GLCter
reaction: metaR FAOXC8DCC6DCx
reaction: metaR EX 6thf LPAREN e RPAREN
species: metaM hxan c
reaction: metaR EX ac LPAREN e RPAREN
reaction: metaR RE3626M
reaction: metaR r1377
reaction: metaR DASCBR
species: metaM CE5121 m
reaction: metaR r2195
reaction: metaR PUNP3
species: metaM gdpfuc c
species: metaM fucfucgalacglcgalgluside hs g
species: metaM pail hs n
reaction: metaR BAAT4x
reaction: metaR EX sbt DASH d LPAREN e RPAREN
species: metaM CE4876 r
reaction: metaR r1608
reaction: metaR r1587
species: metaM cmp e
species: metaM co2 e
reaction: metaR RDH1
reaction: metaR MI14P4P
species: metaM xylu D c
reaction: metaR DNDPt33m
reaction: metaR DASPO1p
reaction: metaR RE1534M
reaction: metaR r0860
species: metaM CE2418 m
reaction: metaR r1544
species: metaM thp2c c
reaction: metaR r0994
species: metaM o2 r
reaction: metaR r0393
species: metaM omhpal r
species: metaM tdcoa m
species: metaM pro D e
reaction: metaR AMETtd
reaction: metaR r0178
reaction: metaR PAIL HStn
species: metaM srtn c
reaction: metaR EX coa LPAREN e RPAREN
species: metaM xol7aone r
reaction: metaR PItx
species: metaM pi n
reaction: metaR FAOXC6DCC4DCx
species: metaM 5adtststerones e
species: metaM pap g
reaction: metaR LEUKTRB4t
species: metaM ptrc e
species: metaM leuktrE4 c
species: metaM dgsn c
reaction: metaR SERGLNexR
reaction: metaR EX for LPAREN e RPAREN
species: metaM CE0785 m
reaction: metaR H2O2tp
reaction: metaR LAPCOAl
reaction: metaR EX oagd3 hs LPAREN e RPAREN
reaction: metaR ACGAMtly
species: metaM gdp n
species: metaM xylt c
reaction: metaR r1570
reaction: metaR r0829
reaction: metaR VALTAm
species: metaM thym c
species: metaM pram c
reaction: metaR UGALNACtg
reaction: metaR TMDK1
reaction: metaR SERDGLYexR

http://identifiers.org/biomodels.db/MODEL1310110032#_13b1eb4f_1384_4a0a_9cfd_c0b6a75c0810
is: Q96FL9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79623
constant: false
name: GALNT14
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false

metaM HC02180 e
is: CHEBI:28728
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: thromboxane-b2
boundary condition: false
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN

metaM prostgd2 e
initial concentration: 1.0
is: HMDB01403
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
has only substance units: false
initial amount: NaN
name: prostaglandin D2(1-)
constant: false

metaM mal L e
initial amount: NaN
is: CHEBI:15589
initial concentration: 1.0
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00156
type: Species
name: (S)-malate(2-)

metaM hxan c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
type: Species
is: HMDB00157
has only substance units: false
name: Hypoxanthine
is: C00262
constant: false
is: CHEBI:17368

metaR ABUTD
product: MODEL1310110032#
reversible: false
is: SBO:0000176
fast: false
name: Aminobutyraldehyde dehydrogenase
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110032#
is described by: ECO:0000269

metaR DM Lcystin
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR r2369
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_2e9e0757_9938_4428_9fdb_52de69efd17b
name: OGDHL
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:55753
is: SBO:0000252
is: Q9ULD0
initial concentration: NaN
constant: false

metaR RE2972M
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.67
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
name: RE2972
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaR BTNt4i
is: SBO:0000185
reversible: false
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: Biotin uptake (antiport)
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110032#_49318dd1_2084_4e61_bec0_ca3940a1e124
name: NMNAT3
is encoded by: hsa:349565
type: Species
is: SBO:0000252
is: Q96T66
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM gly e
constant: false
name: Glycine
initial concentration: 1.0
is: C00037
type: Species
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00123

metaR CYTDK2m
reactant: MODEL1310110032#
reversible: false
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM adp c
is: SBO:0000247
is: HMDB01341
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
constant: false
is: C00008

http://identifiers.org/biomodels.db/MODEL1310110032#_59ab94a4_1df2_4ba4_96c6_44952a0603cd
constant: false
initial amount: NaN
is encoded by: hsa:26289
name: AK5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: Q9Y6K8

metaM pe hs c
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_2b8c0a05_0d99_4033_9002_ae90b692210b
is: SBO:0000252
has only substance units: false
type: Species
name: PTGDS
initial concentration: NaN
is: P41222
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:5730

metaR UMPK2
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: UMP kinase (CTP)
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_2d6b876d_b3ce_4197_b309_588ff998c8de
initial concentration: NaN
name: _D29675_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:D29675

metaR PRO Dtde
kinetic law: MODEL1310110032#
name: D-proline transport, extracellular
type: Reaction
is described by: ECO:0000134
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
reversible: true

metaR RE1526M
reversible: true
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1526
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM fucfucgalacglcgalgluside hs c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Leb glycolipid
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:18287
is: HMDB00174
initial concentration: 1.0
constant: false
type: Species

metaM dadp c
is: SBO:0000247
is: HMDB01508
name: dADP
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
boundary condition: false
constant: false
type: Species
has only substance units: false
is: C00206

http://identifiers.org/biomodels.db/MODEL1310110032#_6048019e_43db_4ea9_a829_ec6cf1503ccc
type: Species
has only substance units: false
initial amount: NaN
name: FUK
is: Q8N0W3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:197258

metaR GARFT
name: phosphoribosylglycinamide formyltransferase
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.1.2.2
fast: false
reversible: true
product: MODEL1310110032#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_4d681517_2373_48b3_a7c2_27f4462848a0
name: ATP10A
is: O60312
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57194

metaR UAGDP
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
name: UDP-N-acetylglucosamine diphosphorylase
is version of: http://identifiers.org/ec-code/2.7.7.23
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_4cc72bcb_2e28_43a2_8ae4_dde92897247a
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: PRPS1L1
constant: false
is encoded by: hsa:221823

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3ef2a129_3028_4d9b_929d_572eee4319c3
is: B4DUG1
type: Species
constant: false
is: SBO:0000252
name: SLC24A1
has only substance units: false
is encoded by: hsa:9187
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_cbefe69c_3dc9_4ea5_80b0_bb88ce5ec3b3
initial amount: NaN
is: P49189
type: Species
has only substance units: false
is encoded by: hsa:223
is: SBO:0000252
constant: false
name: ALDH9A1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_03e41f0c_8c6b_4ee8_a297_0c063d8f065f
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80724
constant: false
name: ACAD10
boundary condition: true
type: Species
is: G3XAJ0
initial amount: NaN
has only substance units: false

metaM pmtcoa r
initial concentration: 1.0
is: CHEBI:3454
constant: false
is: C00154
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_9c252970_bb48_4810_a83d_26e66216b321
name: DCTD
has only substance units: false
type: Species
constant: false
is: P32321
is encoded by: hsa:1635
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_0674ebcc_7581_48a4_861c_2170d9aac27e
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4726
has only substance units: false
name: NDUFS6
boundary condition: true
constant: false
initial concentration: NaN
is: Q6IBC4

http://identifiers.org/biomodels.db/MODEL1310110032#_d5b2a37e_29f1_4c17_968c_78381285a801
name: TXNRD1
is encoded by: hsa:7296
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d5867365_3a25_4a66_9ff7_97bd5ef5b6e6
constant: false
name: GMPS
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P49915
boundary condition: true
is encoded by: hsa:8833
initial concentration: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM sarcs c
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species
is: HMDB00271
has only substance units: false
constant: false
is: C00213
initial concentration: 1.0
boundary condition: false
name: Sarcosine
is: SBO:0000247
initial amount: NaN
is: CHEBI:3513

metaM man l
name: D-mannose
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00169
is: CHEBI:16024
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6a8cbd93_aad2_4d4c_9eb0_2301a8b41dfe
name: FOLR1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2348
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ab46a3cc_c9cb_4399_8009_725ba3278bd5
is: O95498
initial concentration: NaN
is encoded by: hsa:8875
has only substance units: false
name: VNN2
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0633
modifier: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM hxan e
initial concentration: 1.0
is: HMDB00157
boundary condition: false
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17368
name: hypoxanthine
is: SBO:0000247

metaR r1885
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110032#_43604729_15ec_43ab_b716_1d42610321a5
boundary condition: true
has only substance units: false
name: PLCH2
initial concentration: NaN
is: O75038
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:9651
initial amount: NaN

metaM prostgd2 c
initial amount: NaN
is: SBO:0000247
is: HMDB01403
is: CHEBI:57406
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
name: prostaglandin D2(1-)
type: Species
has only substance units: false
initial concentration: 1.0

metaM HC02180 c
boundary condition: false
name: thromboxane-b2
is: SBO:0000247
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:28728
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_30823149_6205_4028_86e5_ee89b6b4f710
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI697028_1_e
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI697028

metaR NDPK10n
type: Reaction
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is described by: ECO:0000304
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM gthox m
type: Species
constant: false
is: CHEBI:58297
initial amount: NaN
is: HMDB03337
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5c345e6c_d007_49a5_bd20_ddf06e033355
boundary condition: true
type: Species
name: _AI915649_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI915649

metaR r0365
product: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR r1298
reactant: MODEL1310110032#
product: MODEL1310110032#
name: Vesicular transport
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM Lcystin e
is: CHEBI:16283
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00192
initial concentration: 1.0
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
constant: false
initial amount: NaN

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r0594
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:

metaM mi14p c
type: Species
initial concentration: 1.0
is: HMDB00968
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58282
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial amount: NaN

metaM adp e
is: SBO:0000247
is: HMDB01341
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
initial concentration: 1.0
name: ADP(3-)
boundary condition: false
has only substance units: false
constant: false
type: Species

metaR DHCRD1
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
name: dihydroceramide desaturase
type: Reaction
modifier: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reactant: MODEL1310110032#

metaM pan4p m
boundary condition: false
type: Species
name: pantetheine 4'-phosphate(2-)
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: SBO:0000247
is: CHEBI:47942
is: HMDB01416

metaR NDPK4n
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110032#
is described by: ECO:0000304
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
kinetic law: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
reversible: true
product: MODEL1310110032#
is: SBO:0000176

metaR r2366
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR DITPtn
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110032#
name: dITP nuclear transport

metaM ascb L e
is: HMDB00044
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
name: L-ascorbate
boundary condition: false
is: CHEBI:38290
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_4ffb9c12_bb6d_42b2_9baa_96b2f460375c
has only substance units: false
type: Species
is encoded by: hsa:84569
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: LYZL1
is: Q6UWQ5
initial concentration: NaN

metaR r0434
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110032#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaR CYTK9n
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269

metaR NADtx
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
product: MODEL1310110032#
name: transport of NAD into peroxisome
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_540a3fe4_c3da_4637_85d1_a9c582f31086
has only substance units: false
name: ACO1
type: Species
boundary condition: true
is encoded by: hsa:48
is: P21399
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0630
modifier: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1

http://identifiers.org/biomodels.db/MODEL1310110032#_5467c21f_c911_46a3_8d21_c8a464af7fa5
boundary condition: true
is encoded by: hsa:4907
type: Species
name: NT5E
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: P21589
is: SBO:0000252

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
name: Y+LAT2 Utilized transport
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110032#
product: MODEL1310110032#

metaR NRPPHRt4 2 r
modifier: MODEL1310110032#
name: Norepinephrine reversible transport in via sodium symport (1:2)
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269

metaM dump m
type: Species
name: dUMP(2-)
is: SBO:0000247
is: HMDB01409
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
has only substance units: false
is: CHEBI:246422
constant: false

metaR r1299
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_04567df4_0bb2_4fc6_92d9_236241044ada
is: SBO:0000252
is encoded by: hsa:622
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: BDH1
initial amount: NaN

metaR DUMPtn
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

metaM hexdiac c
constant: false
initial amount: NaN
is: C08260
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672
has only substance units: false
name: hexadecanediocacid
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_f4627ca7_5273_45a1_af76_8a1482857064
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: FOLR1
initial amount: NaN
type: Species
is encoded by: hsa:2348
initial concentration: NaN

metaR r2365
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110032#
fast: false

metaM pmtcoa x
type: Species
is: CHEBI:57379
initial amount: NaN
initial concentration: 1.0
is: C00154
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3c7d7e1a_343b_4b3f_964f_f287a16e2ab7
is: Q8WUM9
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6574
is: SBO:0000252
name: SLC20A1
has only substance units: false
boundary condition: true

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial amount: NaN
name: pentaglutamyl folate (DHF)
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06487

metaM cl e
is: C00115
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:3966
type: Species
name: Chloride
constant: false
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_3fa1810c_b364_4a71_af92_f04db00685b2
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80025
name: PANK2
boundary condition: true
is: Q6P1K9
initial amount: NaN
is: SBO:0000252

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM fad e
is: C00016
has only substance units: false
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: HMDB01248
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1669
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000

metaM retfa e
type: Species
constant: false
boundary condition: false
is: CHEBI:15963
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00508
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
name: fatty acid retinol

metaM Lcystin c
initial amount: NaN
type: Species
is: CHEBI:16283
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
boundary condition: false
has only substance units: false
constant: false
name: L-cystine
is: SBO:0000247

metaM arachd e
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32395
is: HMDB01043
is: SBO:0000247
boundary condition: false
name: arachidonate

metaM dump n
constant: false
is: CHEBI:246422
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01409
initial amount: NaN
name: dUMP(2-)
initial concentration: 1.0

metaM prpncoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02307
boundary condition: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
type: Species
is: CHEBI:57367
has only substance units: false
name: acryloyl-CoA(4-)
constant: false

metaM ascb L c
is: CHEBI:38290
initial amount: NaN
type: Species
is: HMDB00044
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d685a085_df35_4877_9dfe_b5425ec78749
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110032#_fa768d2c_c892_4956_9ed5_b4b4c9ccd4e6
has only substance units: false
is encoded by: hsa:51166
initial amount: NaN
name: AADAT
boundary condition: true
is: SBO:0000252
constant: false
is: Q8N5Z0
initial concentration: NaN
type: Species

metaR r0027
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaR r2368
reactant: MODEL1310110032#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR 24 25DHVITD3t
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
fast: false
name: 24,25-Dihydroxyvitamin D3 transport from cytoplasm
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

metaR AACOAT
name: Acetoacetyl-CoA:acetate CoA-transferase
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true

metaM glac c
has only substance units: false
initial amount: NaN
is: CHEBI:18268
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-glucurono-6,3-lactone
type: Species
boundary condition: false
is: HMDB06355

metaR GASNASE3ly
reactant: MODEL1310110032#
is: SBO:0000176
reversible: false
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_3f2b4585_0bcd_4434_995b_c864a203880a
initial amount: NaN
is: P04745
initial concentration: NaN
name: AMY1B
is encoded by: hsa:277
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR r2079
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#

metaR CHOLt4
is: SBO:0000185
name: choline, sodium cotransport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaR CYTK14n
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#

metaR RPE
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribulose 5-phosphate 3-epimerase
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR PSt3
kinetic law: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
reversible: true
fast: false
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110032#
is described by: ECO:0000304
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: false
is: SBO:0000176

metaR r1881
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
reversible: false
is: SBO:0000185

metaR r0591
type: Reaction
reversible: true
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_e41716c7_17da_4c0d_bd9a_57e8424f2b1e
initial concentration: NaN
name: NDUFA12
constant: false
is: F8VQS7
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:55967
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d2b90d81_d158_4e7c_b685_d55dbca28a5c
initial amount: NaN
is encoded by: hsa:285973
is: Q674R7
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ATG9B

metaM pail4p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaM HC00695 m
name: S-Succinyldihydrolipoamide
is: CHEBI:17432
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
is: SBO:0000247
has only substance units: false

metaR MI145PP
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR r2367
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaR DADNt4
name: deoxyadenosine transport via diffusion
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000

metaR r0437
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaR CYTK4n
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,GTP),nuclear
type: Reaction
reversible: true
fast: false
product: MODEL1310110032#

metaM fad c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: C00016
initial concentration: 1.0
is: CHEBI:16238
boundary condition: false
type: Species
is: HMDB01248
initial amount: NaN
constant: false

metaM retinal c
name: retinal
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01358
initial concentration: 1.0
is: CHEBI:15035
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376

http://identifiers.org/biomodels.db/MODEL1310110032#_e128dc86_9de6_44db_b783_e78de00bfe88
is encoded by: hsa:157506
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: RDH10
is: Q8IZV5
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9508514f_9ce3_42dd_81a5_05883a65a7aa
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: B1AM93
name: NDUFA8
is: SBO:0000252
is encoded by: hsa:4702

metaR FRDPtc
fast: false
product: MODEL1310110032#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_04699e4e_f59b_473b_8c6f_34e42c8a3773
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: AOC3
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q16853
is encoded by: hsa:8639

http://identifiers.org/biomodels.db/MODEL1310110032#_27ff7fa0_2422_4657_bb96_fdb0abd03199
name: _2544_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2544
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r1655
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110032#
reversible: true

metaM adp x
has only substance units: false
name: ADP(3-)
boundary condition: false
type: Species
is: HMDB01341
is: CHEBI:456216
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false

metaR GALASE14ly
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_08337b36_b388_4f19_8062_7e3374d876b4
constant: false
is: SBO:0000252
is encoded by: hsa:4830
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: NME1
initial amount: NaN

metaR C204CPT2
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: arachidonic acid transport into the mitochondria
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_7ab06b73_e292_4d71_8ae1_94ec8fafb731
is: E7EUT4
constant: false
boundary condition: true
is encoded by: hsa:2597
type: Species
name: GAPDH
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR DHFR
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
name: dihydrofolate reductase
fast: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110032#
product: MODEL1310110032#

metaR SUCCt2m
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
name: succinate transport, mitochondrial
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_f17ffc45_d2a8_40e9_b781_9bf38254964b
name: HAS3
has only substance units: false
is: Q96RV2
is: SBO:0000252
constant: false
is encoded by: hsa:3038
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_5857da1e_30d9_467d_8f1a_7aa87930779a
constant: false
name: _728226_1_m
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:728226
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR MI145PK
type: Reaction
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
name: inositol-1,4,5-trisphosphate 3-kinase
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.127

metaM dad 2 e
is: SBO:0000247
initial amount: NaN
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: 2-deoxyadenosine
is: HMDB00101

metaR r1654
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_5a2e2ad0_a38e_4816_a399_def59f44e297
has only substance units: false
type: Species
constant: false
is: O43678
initial amount: NaN
name: NDUFA2
initial concentration: NaN
is encoded by: hsa:4695
is: SBO:0000252
boundary condition: true

metaR LEULEULAPc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR r1603
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#

metaM ribflv c
is: CHEBI:3554
is: C00255
initial amount: NaN
is: HMDB00244
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false

metaM HC02217 e
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
boundary condition: false
has only substance units: false
constant: false

metaR GLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
name: glucose transport, endoplasmic reticulum
type: Reaction
fast: false

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR r2388
reversible: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR TMDPK
modifier: MODEL1310110032#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.6.2
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
fast: false

metaR BILIRED
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
modifier: MODEL1310110032#
product: MODEL1310110032#
name: Nad(p)h biliverdin reductase
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM lnlccrn c
constant: false
is: HMDB06469
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Linoleyl carnitine

metaR r0443
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
product: MODEL1310110032#
is: SBO:0000176
reversible: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaR r1713
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false

metaR r1653
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r1600
is: SBO:0000185
reversible: true
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ebec933a_27c8_4ddd_bc70_155ad39c260f
has only substance units: false
is encoded by: hsa:55350
name: VNN3
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_96ce0659_8668_47e2_b632_ee4279bdaa3a
boundary condition: true
constant: false
name: MCEE
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84693
initial concentration: NaN
has only substance units: false
is: Q96PE7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_03e7feb6_df68_4a29_b0c9_3b13c6d37ef2
constant: false
type: Species
is encoded by: hsa:411
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P15848
initial amount: NaN
name: ARSB
has only substance units: false

metaM CE5788 e
is: CHEBI:27485
type: Species
initial concentration: 1.0
name: kinetensin 1-7
constant: false
boundary condition: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN
has only substance units: false
is: HMDB02710
is: SBO:0000247

metaR GLYCTDle
kinetic law: MODEL1310110032#
is described by: ECO:0000134
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110032#
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110032#
type: Reaction

metaR APOC LYS BTNPm
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110032#
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction

metaR r2385
kinetic law: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#

metaM q10 e
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
has only substance units: false
is: HMDB01072
name: ubiquinone-10
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:46245
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6cf7ea09_f309_4346_8de5_6a8c52796e3a
constant: false
is: E7ET30
is encoded by: hsa:50808
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: AK3
boundary condition: true
initial concentration: NaN

metaM cs b l
type: Species
is: SBO:0000247
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: C00318
is: HMDB00062
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16347
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_39929797_6086_45a6_8c37_47544892877b
type: Species
initial concentration: NaN
is: B7Z5T8
is: SBO:0000252
has only substance units: false
name: CPT1B
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1375

http://identifiers.org/biomodels.db/MODEL1310110032#_4878aa86_819d_42ac_a738_f9dcf538f8de
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:83884
constant: false
is: Q9BXI2
initial concentration: NaN
name: SLC25A2
is: SBO:0000252

metaR NACHEXA19ly
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
reactant: MODEL1310110032#
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
type: Reaction

metaM arachd l
initial amount: NaN
boundary condition: false
is: HMDB01043
name: arachidonate
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species

metaM C05279 m
initial amount: NaN
is: CHEBI:28387
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: HMDB11123

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
is: SBO:0000247
is: CHEBI:17256
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: 2-deoxyadenosine
constant: false
is: HMDB00101

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#

metaM orot e
is: SBO:0000247
is: CHEBI:30839
boundary condition: false
is: HMDB00226
name: orotate
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR ACCOAtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
name: acetyl-CoA transport, nuclear
is: SBO:0000185
fast: false
reactant: MODEL1310110032#

metaM ksi deg39 l
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: HMDB00143
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 39
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_97383a4b_dbee_4a91_8ec9_880c951864b1
name: AMPD3
constant: false
is: B7Z763
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:272
initial concentration: NaN
initial amount: NaN

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
type: Species
is: CHEBI:57977
constant: false
boundary condition: false
name: bilirubin(2-)
is: HMDB00054
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r2386
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
modifier: MODEL1310110032#
is: SBO:0000185

metaR RE1522M
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
product: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1522
is: SBO:0000176

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
boundary condition: false
name: sodium(1+)
is: HMDB00588
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29101
constant: false
has only substance units: false
type: Species

metaR GLYC3PFADm
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: glycerophosphate shuttle for trasnfer of reducing equivalents
is: SBO:0000176
is described by: ECO:0000134
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b603faec_14c1_49fe_8b52_a47f26bc8ce0
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:37
is: P49748
name: ACADVL
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_cbe9929c_ab42_4e51_b7d0_dbf74b332970
is encoded by: hsa:115286
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: SLC25A26
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q70HW3

metaR r2519
name: Utilized transport
product: MODEL1310110032#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_5fc7cee0_a0e5_462c_8bfe_7892772a1d31
is encoded by: hsa:270
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is: P23109
boundary condition: true
name: AMPD1
initial concentration: NaN

metaR VD3
name: Vitamin D3 formation
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
kinetic law: MODEL1310110032#

metaR r0441
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#

metaR PTPATe
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110032#
name: PTPATe
is described by: ECO:0000134
kinetic law: MODEL1310110032#
reversible: true
fast: false

metaR r1651
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185

metaR URIDK2m
reversible: true
name: uridylate kinase (dUMP), mitochondrial
fast: false
is described by: ECO:0000134
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6527d6ed_ef01_409d_ad07_09504e3779ea
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2746
initial amount: NaN
name: GLUD1
has only substance units: false
type: Species
is: E9KL48
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_41955c25_e628_47ce_b72a_4e02d90731f8
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5315
type: Species
has only substance units: false
is: B4DNK4
is: SBO:0000252
name: PKM2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b5430b63_3b74_4c2d_be3c_575ae7afbbb5
is: P09622
name: DLD
initial concentration: NaN
is encoded by: hsa:1738
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM ptth c
initial amount: NaN
is: CHEBI:16753
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
boundary condition: false
type: Species
name: pantetheine
constant: false
is: SBO:0000247
has only substance units: false

metaM 7thf e
name: heptaglutamyl folate (THF)
has only substance units: false
initial concentration: 1.0
is: HMDB06559
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C49H57N13O24 CHARGE: -8
boundary condition: false

metaM lys L c
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:32551
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00182
name: L-lysinium(1+)

metaM orot5p c
is: C01103
constant: false
has only substance units: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: HMDB00218
name: Orotidine 5'-phosphate
initial amount: NaN
boundary condition: false
is: CHEBI:57538
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r2384
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR RE0577C
name: RE0577
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
product: MODEL1310110032#

metaM oaa m
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
is: C00036
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00223
has only substance units: false
is: CHEBI:16452
initial concentration: 1.0
name: Oxaloacetate
type: Species

metaM gal l
constant: false
boundary condition: false
is: CHEBI:12936
name: D-galactose
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

metaR r1650
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000000

metaR SGPL12r
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110032#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110032#
name: Sphingosine-1-phosphate lyase
product: MODEL1310110032#

metaM 7dhchsterol c
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
is: CHEBI:17759
is: SBO:0000247
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_01db0f01_ac89_4ec9_9ff1_fab1e1e7ea60
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ACOT2
has only substance units: false
constant: false
initial amount: NaN
is: P49753
is encoded by: hsa:10965

metaM amet r
is: HMDB01185
name: S-adenosyl-L-methionine
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15414
is: SBO:0000247

metaR GLNtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
kinetic law: MODEL1310110032#
name: L-glutamine transport via electroneutral transporter
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#

metaR PVD3
kinetic law: MODEL1310110032#
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: Previtamin D3 formation
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a1e8e579_f03f_42b5_961d_5301cb09b171
constant: false
type: Species
boundary condition: true
is: Q86V21
is encoded by: hsa:65985
initial concentration: NaN
has only substance units: false
name: AACS
initial amount: NaN
is: SBO:0000252

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000304
product: MODEL1310110032#
reversible: true
fast: false
modifier: MODEL1310110032#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110032#

metaR KSItly
is: SBO:0000185
name: keratan sulfate I transport, extracellular to lysosome
type: Reaction
kinetic law: MODEL1310110032#
reversible: false
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110032#

metaM 2mop m
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57700
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
boundary condition: false

metaR r0860
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: Utilized transport
product: MODEL1310110032#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f0cad2e9_c18f_406c_a107_b646dde7e1e8
is: SBO:0000252
name: BLVRA
type: Species
boundary condition: true
initial concentration: NaN
is: P53004
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:644

metaR NRPPHRtu
type: Reaction
fast: false
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Norepinephrine uniport
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#

metaM lys L e
is: HMDB00182
is: CHEBI:32551
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR DNDPt25m
reversible: false
product: MODEL1310110032#
name: dTDP transport via dCDP antiport
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_7376b091_14bc_4de4_b12f_a551bacc7a50
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:586
is: P54687
has only substance units: false
initial amount: NaN
name: BCAT1
type: Species
constant: false

metaM mi134p c
initial amount: NaN
is: CHEBI:58414
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
boundary condition: false
initial concentration: 1.0
is: HMDB01143

metaR DNDPt36m
reactant: MODEL1310110032#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: dGDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#

metaR RE1519M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1519
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110032#
type: Reaction
fast: false

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r2382
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b7256156_1c20_40de_bcac_79fc985d7c48
name: B3GNT3
constant: false
initial concentration: NaN
is: Q9Y2A9
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10331
initial amount: NaN

metaR GLNLASEer
is: SBO:0000176
reactant: MODEL1310110032#
name: gluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_bda19bbd_f78f_483d_a3b1_ff5b23453ebd
is encoded by: hsa:6470
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: SHMT1
is: P34896
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR PGI
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.3.1.9
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
name: glucose-6-phosphate isomerase
fast: false
product: MODEL1310110032#

metaR MI13PP
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110032#
name: inositol-1,3-bisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110032#
type: Reaction

metaR ADK3m
name: adentylate kinase (GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true

metaM lthstrl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01170
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17168
name: 5alpha-cholest-7-en-3beta-ol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_4edb5e00_5344_4f93_849d_5fc7283ac59f
initial amount: NaN
name: _H77542_1_c
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:H77542
has only substance units: false
initial concentration: NaN

metaM ribflv e
name: Riboflavin
initial concentration: 1.0
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
initial amount: NaN
is: C00255
type: Species
is: HMDB00244
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5f956ea8_3314_467c_876d_f85ca59b23ee
initial amount: NaN
is encoded by: hsa:218
initial concentration: NaN
is: P30838
has only substance units: false
is: SBO:0000252
constant: false
name: ALDH3A1
type: Species
boundary condition: true

metaM HC02216 c
is: CHEBI:28922
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: prostaglandin-f2beta

http://identifiers.org/biomodels.db/MODEL1310110032#_11e40e0d_573e_46a2_b2df_0b248c7de886
type: Species
is: P33897
boundary condition: true
initial amount: NaN
is encoded by: hsa:215
name: ABCD1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR UROLACer
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
name: uronolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reversible: true
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_64961b25_be34_430a_a521_94068b45f537
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23761
constant: false
name: PISD
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9UG56
has only substance units: false

metaM Rtotal e
is: HMDB00244
is: CHEBI:3554
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
is: C00255
name: R total
initial concentration: 1.0
initial amount: NaN

metaM akg e
has only substance units: false
boundary condition: false
type: Species
is: HMDB00208
name: 2-oxoglutarate(2-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16810
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_4b1602dc_ba08_4301_9f16_17d4b6c046c1
initial concentration: NaN
constant: false
initial amount: NaN
name: _BG035985_1_c
is encoded by: hsa:BG035985
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR BACCL
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: biotin-[acetyl-CoA-carboxylase] ligase
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_57f6751c_9e88_4fd9_845d_cce2ed2b41dc
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1757
is: A8K596
name: SARDH
initial amount: NaN
constant: false

metaM Ser Gly Ala X Gly l
constant: false
boundary condition: false
is: CHEBI:16347
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00062
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: C00318
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false

metaR BTNDe
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
name: biotinidase (biotin), extracellular
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
fast: false
is described by: ECO:0000269

metaM dd2coa m
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712
is: CHEBI:57330
is: SBO:0000247

metaM 2dr1p c
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
constant: false
is: CHEBI:58576
is: SBO:0000247
is: C00672
type: Species
initial amount: NaN
boundary condition: false
name: 2-Deoxy-D-ribose 1-phosphate
has only substance units: false
is: HMDB01351

metaR r2380
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110032#

metaM glcur l
initial concentration: 1.0
is: HMDB00127
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
boundary condition: false
name: D-glucuronate

metaR NACHEXA15ly
modifier: MODEL1310110032#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reactant: MODEL1310110032#
reversible: false

metaM 25hvitd3 c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
is: CHEBI:17933
name: calcidiol
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB03550
initial amount: NaN
has only substance units: false

metaR r0926
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
reversible: false
name: Postulated transport reaction

metaR NACASPtm
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false

metaR PCHOLPm hs
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.4.4
name: choline phosphatase
fast: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
reversible: false

metaM arachd r
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
initial amount: NaN
initial concentration: 1.0
name: arachidonate
boundary condition: false
type: Species
is: HMDB01043
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_82aaabf9_32ee_4b7c_aa35_2f40bd23d143
is encoded by: hsa:29925
type: Species
is: Q9Y5P6
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: GMPPB
initial concentration: NaN

metaR CYSTGL
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
is version of: http://identifiers.org/ec-code/4.4.1.1
is described by: ECO:0000269
type: Reaction
name: cystathionine g-lyase
is: SBO:0000176
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_a062c170_73a9_40f7_b114_a7dd423777a7
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLCO1A2
constant: false
initial concentration: NaN
is encoded by: hsa:6579
is: P46721
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_e985c540_bdc8_4b92_adce_73c97f77675d
initial amount: NaN
initial concentration: NaN
is: Q53Y41
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1644
constant: false
name: DDC
is: SBO:0000252

metaM so3 m
name: hydrogensulfite
boundary condition: false
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00240

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reversible: false
type: Reaction
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3

metaM cytd m
is: CHEBI:17562
name: cytidine
is: HMDB00089
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_f52400ff_bf1a_4508_94b6_b083148e55d0
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110032#_394d0a98_50eb_43e8_a258_a30c62565ba1
is: SBO:0000297
type: Species
is encoded by: hsa:6391
initial concentration: NaN
is encoded by: hsa:6389
has part: P31040
has only substance units: false
is encoded by: hsa:6390
has part: Q99643
is encoded by: hsa:6392
constant: false
name: SDHA:SDHB:SDHC:SDHD
initial amount: NaN
boundary condition: true
has part: P21912
has part: O14521

metaR THRGLYexR
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110032#

metaM r5p r
has only substance units: false
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
constant: false
is: CHEBI:18189
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

metaM oaa x
initial concentration: 1.0
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223
is: CHEBI:16452
has only substance units: false
is: SBO:0000247
is: C00036
boundary condition: false
name: Oxaloacetate
constant: false
initial amount: NaN

metaM HC02216 e
is: CHEBI:28922
type: Species
name: prostaglandin-f2beta
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR r0153
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
product: MODEL1310110032#
reversible: false
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#

metaR EHGLATm
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110032#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110032#
reversible: false
is described by: ECO:0000212
is: SBO:0000176
fast: false

metaM akg c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-Oxoglutarate
type: Species
initial concentration: 1.0
is: HMDB00208
is: C00026
is: CHEBI:16810
has only substance units: false
is: SBO:0000247

metaR r2439
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
reversible: false
type: Reaction
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

metaR r1608
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f96e4155_4767_4fb6_9873_47af69555430
boundary condition: true
name: NDUFAB1
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: O14561
is encoded by: hsa:4706
initial concentration: NaN

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_22f0632f_4b8f_415e_90de_d823172d21d6
type: Species
boundary condition: true
is: P32019
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: INPP5B
is encoded by: hsa:3633

metaR LEUKTRB4t
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
name: leukotriene B4 transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#

metaM pail4p hs c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58178
type: Species
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110032#_9ae25725_d0ff_4efe_b97d_3b38f2366e4f
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
initial concentration: NaN
name: _AI971036_1_m
boundary condition: true
has only substance units: false
type: Species

metaR HACD9m
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110032#

metaR DOPAtu
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Dopamine uniport
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM q10 m
boundary condition: false
is: HMDB01072
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false
name: ubiquinone-10
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:46245

metaR GLUDym
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: glutamate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is: SBO:0000176

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
type: Species
initial amount: NaN
is: HMDB00812
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042

http://identifiers.org/biomodels.db/MODEL1310110032#_1d3a74d8_14df_4418_8387_7068d19d5a2f
is: E9KL42
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACOT1
is: SBO:0000252
is encoded by: hsa:641371
constant: false

metaR PSDm hs
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
type: Reaction
product: MODEL1310110032#
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65

metaM l2n2m2mn l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
type: Species
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: HMDB00143
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR r1609
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110032#

metaR THFtm
fast: false
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_b6cbfef6_b3bb_4bea_a06d_de37e8ccb468
constant: false
name: PPA2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:27068
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_cab3138c_d63c_43d1_b4f9_37a3d50d73e6
initial concentration: NaN
boundary condition: true
name: OXSM
is encoded by: hsa:54995
type: Species
constant: false
is: Q9NWU1
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_a0b34f02_3933_48cd_ad70_e541737b683a
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC26A1
is encoded by: hsa:10861
boundary condition: true
type: Species
has only substance units: false

metaR 2OXOADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
modifier: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110032#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reversible: true
type: Reaction

metaR PROSTGE2t
reactant: MODEL1310110032#
is described by: ECO:0000269
fast: false
is: SBO:0000185
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaM ethamp c
name: ethamp[c]
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00224
is: SBO:0000247
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190

metaR TMDPP
type: Reaction
is described by: ECO:0000269
name: thymidine phosphorylase
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.4
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_b69f4e58_eabc_48e5_aec0_683ecb6211ad
name: COX6B1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P14854
is encoded by: hsa:1340
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaR HSD3A1r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.225

metaR UMPK3n
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110032#

metaM CE2420 m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
boundary condition: false
constant: false
is: SBO:0000247
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110032#_9793e7d7_ab02_4199_b60d_308cea33aadc
is: O14734
initial concentration: NaN
constant: false
is: SBO:0000252
name: ACOT8
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10005

metaM din c
boundary condition: false
initial amount: NaN
is: HMDB00071
has only substance units: false
name: Deoxyinosine
initial concentration: 1.0
constant: false
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
is: SBO:0000247
is: CHEBI:28997

metaM HC01405 m
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: CHEBI:28632
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_26003392_40ba_435e_9719_d2bbd51e70a8
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P14672
initial concentration: NaN
type: Species
name: SLC2A4
is encoded by: hsa:6517
has only substance units: false
constant: false

metaM k e
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
initial concentration: 1.0
initial amount: NaN
name: potassium
is: CHEBI:29103
boundary condition: false
is: HMDB00586
has only substance units: false
constant: false
is: SBO:0000247
is: C00238

metaR MAL Lte
fast: false
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000134
name: Transport of L-malate
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185

metaM gal e
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00143
is: CHEBI:0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: C00124
name: D-Galactose

metaR r1546
kinetic law: MODEL1310110032#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM glcur r
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15748
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00127

metaR r1429
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Free diffusion
kinetic law: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_93799a39_c513_4cde_a021_a778765d8c48
constant: false
boundary condition: true
is: Q06830
name: PRDX1
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5052
is: SBO:0000252

metaR r0715
product: MODEL1310110032#
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.5
is: SBO:0000176

metaR r1606
reactant: MODEL1310110032#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#

metaR r2437
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3ce13c3e_4485_424f_9374_adeca58e7796
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC26A3
boundary condition: true
is encoded by: hsa:1811
is: SBO:0000252
has only substance units: false
is: P40879
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ee99a0b1_6947_447b_9e91_0fe03a3c3366
has only substance units: false
initial concentration: NaN
name: PPT2
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q9UMR5
is encoded by: hsa:9374

metaR TYRATB0tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the intestinal cells by ATB0 transporter
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR ALDD2y
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000000

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
is: HMDB06404
initial amount: NaN
type: Species
constant: false
is: C05274
has only substance units: false

metaR SIAASEly
name: sialidase, lysosomal
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR NMNS
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
kinetic law: MODEL1310110032#
name: NMN synthetase
product: MODEL1310110032#
is: SBO:0000176
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110032#

metaR GHMT2r
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
name: glycine hydroxymethyltransferase, reversible
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_d2b1daf9_4e45_4a19_b3ec_92873fbac88e
has only substance units: false
initial amount: NaN
name: ACSS1
is: Q9NUB1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110032#_a75b9ee6_cc96_4049_ad4b_e48078e1157d
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DHFR
constant: false
is encoded by: hsa:1719
has only substance units: false
is: P00374

http://identifiers.org/biomodels.db/MODEL1310110032#_00204f66_520a_4c4e_8b90_53e646a11d31
name: EPX
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8288
constant: false
is: P11678

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r1428
is: SBO:0000185
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM glu L e
is: CHEBI:29985
is: HMDB00148
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
initial concentration: 1.0
type: Species
name: L-glutamate(1-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_1edf03f4_9218_4ea7_95e5_d280f398b93a
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACOX1
type: Species
initial concentration: NaN
constant: false
is: B4DK61
is encoded by: hsa:51
is: SBO:0000252

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true

metaR r0716
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#

metaR ATPtm
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110032#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0156
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_57dd3e77_2f42_4f31_8f1d_8c2ec7e476ed
is encoded by: hsa:3032
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: HADHB
initial concentration: NaN
is: P55084

metaM 3hpp m
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16510
boundary condition: false
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
name: 3-hydroxypropionate
has only substance units: false

metaM din e
initial amount: NaN
boundary condition: false
is: HMDB00071
constant: false
is: C05512
initial concentration: 1.0
has only substance units: false
name: Deoxyinosine
type: Species
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
is: CHEBI:28997

http://identifiers.org/biomodels.db/MODEL1310110032#_ace35a05_fb11_43db_8bb1_6ca0c2f3815f
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110032#_ab9552ae_fe5f_48c7_be50_db437d2d3f7e
initial amount: NaN
boundary condition: true
is encoded by: hsa:84532
name: ACSS1
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q9NUB1
has only substance units: false

metaR PYK
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110032#
reversible: false
name: pyruvate kinase
is: SBO:0000176
product: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_be9aa15a_cd37_43c5_910f_57759278ec9f
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: ACP1
is: SBO:0000252
is: Q59EH3
is encoded by: hsa:52

metaR THRPHELAT2tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_42b2ee7e_de43_4c2f_9fd3_aa02af4eba5f
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:286297
has only substance units: false
name: _286297_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_8e3f261e_a50b_4eea_897a_c79a8d6ce7b4
initial concentration: NaN
name: SLC26A6
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9Y3Y1
is encoded by: hsa:65010
boundary condition: true

metaR r1604
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_89f1f3f1_c62c_4c63_802b_a30ec2bcbdf6
is: SBO:0000252
has only substance units: false
name: ALDH1A2
is encoded by: hsa:8854
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: O94788
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ac5c66f5_69d5_4dc8_83cf_a5e254a81e71
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: LHPP
is: Q9H008
has only substance units: false
is encoded by: hsa:64077
constant: false
boundary condition: true

metaR r0796
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56

metaR r1544
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM gal c
is: SBO:0000247
is: C00124
initial concentration: 1.0
boundary condition: false
is: CHEBI:0
initial amount: NaN
constant: false
is: HMDB00143
has only substance units: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose

metaR CLFORtex
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000304
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
reversible: false
name: chloride transport via formate countertransport

metaR r0157
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/6.3.4.2
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
is: SBO:0000176

metaR r1818
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9f52f740_f3bc_4412_942d_2873274e7841
has only substance units: false
is: SBO:0000252
name: _728637_1_c
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:728637
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_73687cbf_121d_467e_af1c_16e897f7b917
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:PRO1933
name: _PRO1933_1_m
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_80dc00e3_7689_4201_85e8_8e7642798446
is encoded by: hsa:U37519
boundary condition: true
has only substance units: false
name: _U37519_1_m
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaR RE0583C
is: SBO:0000176
is described by: ECO:0000000
name: RE0583
fast: false
product: MODEL1310110032#
type: Reaction
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_15afaa46_ef15_4d7e_b571_be4a4f64fd9f
has only substance units: false
name: KDSR
is: Q06136
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2531

metaR ARAB Lt
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is: SBO:0000185
reversible: true
name: L-arabinoase extracellular transport
type: Reaction
product: MODEL1310110032#

metaM 25hvitd3 e
constant: false
is: SBO:0000247
is: HMDB03550
name: calcidiol
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17933
initial concentration: 1.0

metaM lys L m
constant: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: L-lysinium(1+)
is: SBO:0000247
is: HMDB00182
is: CHEBI:32551

metaM urcan c
name: Urocanate
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00301
initial amount: NaN
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: C00785
type: Species
boundary condition: false
is: CHEBI:17771

metaR r0714
type: Reaction
reversible: false
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110032#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110032#
fast: false
is described by: ECO:0000000

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dgchol x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00637
has only substance units: false
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
name: glycochenodeoxycholate
constant: false
type: Species

metaM glu L c
initial amount: NaN
is: CHEBI:29985
is: HMDB00148
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
constant: false
name: L-glutamate(1-)
boundary condition: false
initial concentration: 1.0
type: Species

metaM arachd x
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
is: HMDB01043
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: arachidonate
initial concentration: 1.0
is: CHEBI:32395

http://identifiers.org/biomodels.db/MODEL1310110032#_393dc1fc_b9f1_4377_9db8_9a26f1fbe80b
is: Q6IBC4
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4726
initial concentration: NaN
initial amount: NaN
constant: false
name: NDUFS6
boundary condition: true

metaM ctp c
is: CHEBI:37563
is: C00063
initial concentration: 1.0
name: CTP
initial amount: NaN
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM gtp c
type: Species
has only substance units: false
initial concentration: 1.0
name: GTP
boundary condition: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
initial amount: NaN
is: HMDB01273
is: C00044
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_7ca29646_eebe_4b60_af12_854ea8e0f84e
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
name: XDH
is: P47989
is encoded by: hsa:7498
is: SBO:0000252
initial amount: NaN

metaM fe3 e
boundary condition: false
type: Species
name: Fe3+
is: CHEBI:29034
initial amount: NaN
has only substance units: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB12943

metaM thmmp c
boundary condition: false
initial amount: NaN
is: C01081
is: SBO:0000247
name: Thiamin monophosphate
is: CHEBI:37575
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial concentration: 1.0
constant: false
is: HMDB02666
type: Species
has only substance units: false

metaR r1549
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaM bilirub c
is: HMDB00054
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57977

metaM cdp m
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01546
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069

metaR r0797
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
name: glycine N-choloyltransferase EC:2.3.1.65
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_70a9e8ca_4906_48d9_87e0_a1fe3371638e
initial amount: NaN
boundary condition: true
is encoded by: hsa:2806
constant: false
has only substance units: false
type: Species
is: P00505
is: SBO:0000252
initial concentration: NaN
name: GOT2

metaM glyc R c
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:16659
initial concentration: 1.0
name: D-glycerate
type: Species
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_d9b4d965_25c2_477f_93a0_f2574120c579
initial concentration: NaN
is: O14556
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
name: GAPDHS
is encoded by: hsa:26330

metaR HEX1
is described by: ECO:0000134
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
fast: false
reversible: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.1

metaR r0584
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true

metaR RE2541E
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: RE2541
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is: SBO:0000176
type: Reaction
fast: false

metaR FRDPtr
kinetic law: MODEL1310110032#
name: lipid, flip-flop intracellular transport
type: Reaction
reversible: true
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000185

metaR CO2tm
fast: false
name: CO2 transport (diffusion), mitochondrial
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7b1c6922_e5d2_4876_a1c9_33f5bc6c8987
is: SBO:0000252
type: Species
is encoded by: hsa:216
has only substance units: false
name: ALDH1A1
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: P00352

metaM 7dhchsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
boundary condition: false
is: HMDB00032
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:17759

http://identifiers.org/biomodels.db/MODEL1310110032#_606b0384_e19e_4d7b_95b2_babab4ac9f18
constant: false
name: _NM_001929_1_c
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:NM 001929
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_1a8b0dad_6970_4aee_8c02_4f9a59ec2709
constant: false
initial amount: NaN
name: GALNT11
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:63917
initial concentration: NaN
is: B3KWF4

metaR FE3MTP1
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
name: transport of ferrous iron into blood
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
reversible: false

metaR EX 2425dhvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 24R,25-Dihydroxyvitamin D3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_e0dffac2_f474_40ec_920b_fb99250aa680
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: Q9H2X9
has only substance units: false
name: SLC12A5
type: Species
is encoded by: hsa:57468
initial concentration: NaN

metaM 2mop c
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
is: HMDB01172
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:57700

metaM tyr L c
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
boundary condition: false
type: Species
is: CHEBI:17895
name: L-tyrosine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00158

http://identifiers.org/biomodels.db/MODEL1310110032#_834cc59a_287c_4302_8371_5360eefd20ad
initial amount: NaN
initial concentration: NaN
type: Species
name: _AA526438_1_c
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA526438

metaM ins c
name: Inosine
constant: false
initial concentration: 1.0
is: HMDB00195
is: C00294
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17596
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
has only substance units: false

metaR ENGASE2ly
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_abef1b28_7961_4601_b84f_c3f21fd53cb4
name: NDUFA1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4694
is: Q6IBB5
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_7f4bd9d2_9e48_42c8_abdc_9eb4dd880eaa
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AF116616
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AF116616_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_926631f7_ed66_4054_9af3_cd8c028b056a
initial concentration: NaN
name: SLC7A8
constant: false
type: Species
initial amount: NaN
is: Q86U05
boundary condition: true
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000252

metaM HC00460 c
constant: false
initial amount: NaN
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: CHEBI:58044
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

metaR DOPASULT
product: MODEL1310110032#
reversible: false
type: Reaction
reactant: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
name: Dopamine Sulfotransferase
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_ad4e920d_003e_4f1a_8594_d72d20d1c6bd
constant: false
name: GLRX2
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51022

http://identifiers.org/biomodels.db/MODEL1310110032#_4060dbe2_3c49_44f4_a8ee_6e7db2c13a41
name: SDR16C5
constant: false
initial concentration: NaN
is: SBO:0000252
is: B3KT84
is encoded by: hsa:195814
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM udp e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: CHEBI:58223
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: UDP(3-)
is: HMDB00295

metaR H2Otp
reactant: MODEL1310110032#
is: SBO:0000185
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110032#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaM occoa x
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
is: C01944
is: CHEBI:57386
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01070
type: Species
is: SBO:0000247

metaR PRPNCOAHYDm
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110032#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
reactant: MODEL1310110032#

metaM na1 e
is: SBO:0000247
constant: false
is: CHEBI:4541
boundary condition: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
name: Sodium
type: Species
is: C01330
initial concentration: 1.0
has only substance units: false
is: HMDB00588

http://identifiers.org/biomodels.db/MODEL1310110032#_ac7434fc_c720_4fd8_b19d_2bc2183756c5
is encoded by: hsa:8803
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: SUCLG1:SUCLA2
has part: E5KS60

metaM so3 c
is: CHEBI:17137
initial amount: NaN
boundary condition: false
is: C00094
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: Sulfite
is: SBO:0000247

metaR NACHEXA12ly
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3e86979d_a169_45be_b15f_e24597be37da
type: Species
boundary condition: true
is: P51648
constant: false
name: ALDH3A2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:224

http://identifiers.org/biomodels.db/MODEL1310110032#_8cd1a2de_ad00_4980_803f_04249e1f3cb2
has only substance units: false
is encoded by: hsa:10201
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: NME6
is: O75414
is: SBO:0000252

metaM sgalside hs c
initial concentration: 1.0
is: HMDB03406
name: sulfatide galactocerebroside
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16523
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR r1827
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false

metaR CYSO
is version of: http://identifiers.org/ec-code/1.13.11.20
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
name: cysteine oxidase
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: false
fast: false

metaM frdp c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: C00448
is: CHEBI:175763
type: Species
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: HMDB00961
name: Farnesyl diphosphate

metaR r1547
fast: false
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000

metaM udp g
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
initial concentration: 1.0
has only substance units: false
type: Species
name: UDP(3-)
is: SBO:0000247
boundary condition: false

metaR BTNDm
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
name: biotinidase (biotin), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110032#_b6e1f4bf_6d9d_424c_82b8_ce9572c897e3
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AMPD2
is: Q01433
is encoded by: hsa:271
has only substance units: false
boundary condition: true
constant: false

metaR RETt
reversible: false
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
name: Retinol transport via faciliated diffusion
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

metaR GLCAASE9ly
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
type: Reaction
reversible: false
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_8d63f405_4349_46aa_9389_6d97134246b5
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80347
name: COASY
is: Q13057
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM pheme c
is: CHEBI:17627
boundary condition: false
initial amount: NaN
name: Protoheme
is: C00032
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: HMDB03178

metaM ppa m
is: CHEBI:17272
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
name: propionate
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00237

http://identifiers.org/biomodels.db/MODEL1310110032#_d6958826_3ee0_4858_a158_0f3f014e62a3
initial amount: NaN
boundary condition: true
is: O95477
constant: false
is encoded by: hsa:19
has only substance units: false
name: ABCA1
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1826
modifier: MODEL1310110032#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR r1423
fast: false
name: Facilitated diffusion
reversible: false
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

metaR r1548
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pac c
boundary condition: false
type: Species
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
is: HMDB00209
is: SBO:0000247
has only substance units: false
name: phenylacetate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18401

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_4414b294_8b30_4457_835a_29527f25f70f
type: Species
is: SBO:0000252
boundary condition: true
is: Q9NWU1
is encoded by: hsa:54995
name: OXSM
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_87cc7cd7_dc71_4396_8581_0f06f6b030e4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AI435857_1_x
has only substance units: false
is encoded by: hsa:AI435857
type: Species
constant: false
boundary condition: true

metaR H2Otn
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
name: H2O transport, nuclear
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false

metaM ins e
has only substance units: false
name: Inosine
is: HMDB00195
initial concentration: 1.0
is: C00294
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17596
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1008a4ab_50a0_4fae_8727_d237a7bc0649
has only substance units: false
name: SLC27A4
initial concentration: NaN
is: Q6P1M0
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:10999

metaM cytd e
is: HMDB00089
initial concentration: 1.0
type: Species
name: Cytidine
is: C00475
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM na1 c
is: HMDB00588
boundary condition: false
is: CHEBI:4541
is: SBO:0000247
constant: false
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
name: Sodium
type: Species
has only substance units: false
is: C01330
initial concentration: 1.0

metaM HC02208 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
is: CHEBI:27696
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_40202c14_c14e_44aa_b088_a2ef4f85661c
has only substance units: false
type: Species
initial amount: NaN
name: SLC27A1
constant: false
initial concentration: NaN
boundary condition: true
is: Q6PCB7
is: SBO:0000252
is encoded by: hsa:376497

http://identifiers.org/biomodels.db/MODEL1310110032#_41ab5237_c66e_4092_b6b3_8091790f8a5f
initial concentration: NaN
boundary condition: true
type: Species
is: Q53HM1
has only substance units: false
name: UCKL1
is encoded by: hsa:54963
is: SBO:0000252
constant: false
initial amount: NaN

metaR GNMT
is version of: http://identifiers.org/ec-code/2.1.1.20
product: MODEL1310110032#
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110032#
name: glycine N-methyltransferase
reactant: MODEL1310110032#
fast: false

metaR RE0926E
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110032#
is described by: ECO:0000000

metaR PEt
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
fast: false
type: Reaction
name: phosphatidylethanolamine transport

metaR SRTNt6 2 r
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00751
name: L-xylulose
is: CHEBI:17399

metaR THD1m
modifier: MODEL1310110032#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.1.2
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
name: NAD(P) transhydrogenase
is: SBO:0000185
is described by: ECO:0000269

metaR r0160
reversible: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
fast: false
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.1.3.2
type: Reaction
is described by: ECO:0000000

metaR DCK1n
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (ATP)
fast: false
reversible: true
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7eb41e91_7d21_45b1_96b8_8ffdeb9a5a5d
is: P19174
initial amount: NaN
name: PLCG1
is encoded by: hsa:5335
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_b12b1861_8726_49da_ad4d_85ccdfa6439d
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9BV79
name: MECR
initial amount: NaN
is encoded by: hsa:51102
has only substance units: false
type: Species
boundary condition: true

metaM HC01397 m
constant: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
is: CHEBI:27402
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR CDSm
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
type: Reaction
name: phosphatidate cytidylyltransferase
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
reactant: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_989e8d10_4c59_4d3f_96c8_1d6c66540bcb
is encoded by: hsa:29925
initial amount: NaN
name: GMPPB
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_35a82c55_021f_4894_8e8b_c6da0eb1d9fe
is: Q9Y5P4
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:10087
name: COL4A3BP
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_ce578642_10c4_479b_b58e_c73eb5b7d22c
initial amount: NaN
initial concentration: NaN
name: HAO2
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51179

metaM xylt e
is: HMDB02917
boundary condition: false
initial concentration: 1.0
constant: false
name: xylitol
is: CHEBI:17151
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaR r1421
is: SBO:0000185
fast: false
reversible: true
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110032#

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
is: SBO:0000176
reactant: MODEL1310110032#

metaR TYMSULT
is: SBO:0000176
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.8.2.1
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
reversible: false
fast: false
product: MODEL1310110032#
name: Tyramine Sulfotransferase
reactant: MODEL1310110032#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR LYStip
fast: false
reversible: false
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: L-lysine transport, peroxisomal (irreversible)

metaR RE1448N
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
name: RE1448
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true

metaR FATP2t
product: MODEL1310110032#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
modifier: MODEL1310110032#

metaM pheme e
is: C00032
name: Protoheme
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17627
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN

metaR ALASm
kinetic law: MODEL1310110032#
name: 5-aminolevulinate synthase
fast: false
type: Reaction
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reversible: false
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.37
is described by: ECO:0000254
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_be88f199_5423_48ee_8856_a3a6b2ca7119
name: BTD
has only substance units: false
initial amount: NaN
is encoded by: hsa:686
is: P43251
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaM gbside hs g
is: CHEBI:18259
initial amount: NaN
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_a51b538c_48f5_4fe8_aea2_5ac307057c1c
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3098
constant: false
has only substance units: false
is: P78542
boundary condition: true
initial concentration: NaN
name: HK1

http://identifiers.org/biomodels.db/MODEL1310110032#_cc1c53ba_6bb5_4fac_a2dd_fad7641d9a90
has only substance units: false
is: B7Z1R0
is: SBO:0000252
type: Species
name: SLC4A10
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57282

metaR ATPH1e
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
name: ATP diphosphohydrolase
is: SBO:0000176
product: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM chsterol c
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
constant: false
boundary condition: false
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110032#_8666eb41_2c78_401b_976b_42d2dc0540e2
is: SBO:0000252
name: SLC25A1
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: D9HTE9
is encoded by: hsa:6576

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM mn l
is: SBO:0000247
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
constant: false
is: HMDB06535
initial amount: NaN

metaR RE1530C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
kinetic law: MODEL1310110032#
name: RE1530
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176

metaR r0932
reactant: MODEL1310110032#
name: Transport reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction

metaM hmgcoa c
boundary condition: false
initial concentration: 1.0
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
constant: false
has only substance units: false

metaR FUCASEly
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: alpha-fucosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110032#_cd050f32_4852_4431_b947_2fdb67f31c20
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: FTCD
is encoded by: hsa:10841
is: O95954
is: SBO:0000252
initial concentration: NaN

metaM bilirub e
constant: false
initial amount: NaN
name: bilirubin(2-)
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_c9b8b8a8_13fb_42f4_946b_a4d464cc661e
is: O15357
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: INPPL1
is encoded by: hsa:3636
is: SBO:0000252
type: Species
boundary condition: true

MODEL1310110032#
species: metaM gthrd m
species: metaM sgalside hs c
species: metaM HC00250 c
species: metaM itp e
species: metaM HC02202 c
species: metaM udpglcur c
species: metaM 3hbcoa m
species: metaM utp e
species: metaM ppi m
species: metaM HC01412 m
species: metaM h2o2 c
species: metaM crn x
species: metaM din e
species: metaM fald e
species: metaM lnlnca c
species: metaM xol7aone m
species: metaM L2aadp6sa c
name: GLB1:CTSA
stoichiometry: 9.0
species: metaM paf hs e
species: metaM pyr e
species: metaM ura c
species: metaM udpacgal c
species: metaM arab L c
species: metaM acnam l
species: metaM man c
species: metaM HC02205 e
species: metaM cs b deg3 l
species: metaM apoC Lys m
species: metaM pe hs c
species: metaM tdcoa x
species: metaM h2o g
species: metaM lnlccrn m
species: metaM pi e
species: metaM chol n
species: metaM andrstrn r
species: metaM ac m
species: metaM glutcoa m
species: metaM ala L c
species: metaM gsn e
species: metaM pi g
species: metaM icit c
species: metaM gchola c
species: metaM HC00319 c
species: metaM sarcs c
species: metaM hom L e
species: metaM aacoa x
species: metaM dgtp c
species: metaM fad r
species: metaM pram c
species: metaM HC01231 c
species: metaM trdrd m
species: metaM xylu D c
species: metaM digalsgalside hs c
species: metaM methf m
stoichiometry: 0.005829
species: metaM 10fthf c
species: metaM itp c
species: metaM 3oddcoa m
species: metaM pro L m
species: metaM 4abut m
species: metaM cs a deg5 l
species: metaM 13dpg c
species: metaM succ x
species: metaM HC01231 m
species: metaM mal L x
species: metaM 10fthf e
species: metaM pep c
species: metaM HC01407 m
species: metaM nh4 n
species: metaM 25hvitd3 c
species: metaM Tn antigen l
species: metaM oaa x
species: metaM ascb L c
species: metaM core6 l
species: metaM HC01415 m
species: metaM 13dampp c
species: metaM dgsn c
species: metaM prpp c
species: metaM hdd2coa x

metaR HIStiDF
is: SBO:0000185
modifier: MODEL1310110032#
fast: false
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000269
name: L-histidine transport via diffusion (extracellular to cytosol)
reversible: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR r2061
is described by: ECO:0000000
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110032#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi deg12 l
is: HMDB00143
name: keratan sulfate I, degradation product 12
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: CHEBI:12936
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_827deb69_e1d6_4aee_9b69_527b5d6716a5
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2588
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: GALNS
is: P34059

metaM atp r
name: ATP(4-)
is: CHEBI:57299
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: C00002
initial amount: NaN
is: HMDB00538
initial concentration: 1.0
has only substance units: false

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM sgalside hs g
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00061
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: CHEBI:58343
is: SBO:0000247
type: Species

metaM amet c
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
type: Species
boundary condition: false
name: S-Adenosyl-L-methionine
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01185
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_cd9eaf30_681d_4e81_8120_7214eb5a8e27
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: ACLY
is encoded by: hsa:47
initial amount: NaN
is: SBO:0000252

metaM fe3 c
has only substance units: false
notes: FORMULA: Fe CHARGE: 3
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB12943
boundary condition: false
constant: false
name: Fe3+

metaR ACGAMPM
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is version of: http://identifiers.org/ec-code/5.4.2.3
name: phosphoacetylglucosamine mutase
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#

metaR FACOAL204
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
type: Reaction
name: fatty-acid--CoA ligase
modifier: MODEL1310110032#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR CYTK9
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_040b3488_13a5_4422_b479_eb07a7cf021b
boundary condition: true
is: Q9Y6M9
is encoded by: hsa:4715
initial concentration: NaN
name: NDUFB9
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR DHAPtc
product: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: transport of DHAP into cytosol
kinetic law: MODEL1310110032#
is described by: ECO:0000134
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_394f9125_bc74_4e2c_aac6_03e59e6c1284
is: Q5QPH3
is: SBO:0000252
name: ACSS2
is encoded by: hsa:55902
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_ff7ee81c_4392_4785_8c83_8d11eaa0e45a
boundary condition: true
constant: false
is encoded by: hsa:2592
name: GALT
is: E7ET32
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_372c1d24_3a96_46bc_94b4_075bc41b1da0
is: Q9UKG4
name: SLC13A4
boundary condition: true
is encoded by: hsa:26266
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_af5b9dfe_49ba_4c68_95cf_c3910b290822
name: CHAT
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1103
initial concentration: NaN
is: Q6LEN6
is: SBO:0000252

metaM udp l
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: UDP(3-)
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: HMDB00295
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110032#_4b99333a_abd0_4795_8adb_3957cb20837d
initial amount: NaN
is: SBO:0000297
has part: Q86U05
is encoded by: hsa:23428
constant: false
initial concentration: NaN
has only substance units: false
name: SLC7A8:SLC3A2
type: Species
boundary condition: true

metaR r0931
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#

metaM xylt c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: xylitol
is: HMDB02917
constant: false
is: CHEBI:17151
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

http://identifiers.org/biomodels.db/MODEL1310110032#_444f1e62_814b_4874_bb97_db62d8f2abbf
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:113452
type: Species
is: Q969K7
name: TMEM54
is: SBO:0000252

metaR CLOXAtex2
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
reversible: false
modifier: MODEL1310110032#
name: chloride transport via oxalate countertransport (2:1)
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction

metaR GHMT2rm
modifier: MODEL1310110032#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
name: glycine hydroxymethyltransferase, reversible, mitochondrial
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
fast: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR BPNT
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
name: 3',5'-bisphosphate nucleotidase
reversible: false
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.7
modifier: MODEL1310110032#
is described by: ECO:0000269

metaR PAIL45P HStn
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110032#

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
name: cholesterol
is: SBO:0000247
is: HMDB00067
constant: false
has only substance units: false

metaR ASNtN1
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
name: Asparagine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110032#_4c5c0aa3_410b_45ed_a42a_7dcdf6c935ad
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: EHHADH
is: Q9NY65
is encoded by: hsa:1962
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR ADRNt
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_12d9c2b9_1499_4ef6_abd4_bf6f311dc465
constant: false
is: SBO:0000252
is: P37268
name: FDFT1
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2222

metaR GK1
type: Reaction
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6447a085_37b9_46ab_8420_5a04c6671335
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:343
name: AQP8
has only substance units: false
is: O94778
is: SBO:0000252

metaR ARACHDtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110032#
reversible: true
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
name: intracellular transport
product: MODEL1310110032#
is: SBO:0000185

metaR DUTPDPm
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.23
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reactant: MODEL1310110032#
name: dUTP diphosphatase
product: MODEL1310110032#
fast: false

metaM lys L x
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:32551
is: HMDB00182
is: SBO:0000247
name: L-lysinium(1+)

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f8fb2fb0_6b8d_4782_9f22_379961886594
is: SBO:0000252
has only substance units: false
name: SLC3A1
is: Q07837
boundary condition: true
is encoded by: hsa:6519
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM C05965 e
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: 12(S)-HPETE(1-)
boundary condition: false
is: HMDB04243

http://identifiers.org/biomodels.db/MODEL1310110032#_617ef194_4d4b_4d02_a099_a994cdc0d16f
is: P51648
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: ALDH3A2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:224
constant: false

metaR CYTK7
modifier: MODEL1310110032#
type: Reaction
name: cytidylate kinase (CMP,UTP)
product: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110032#

metaR PI345P5P
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110032#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reversible: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110032#

metaM HC02187 e
is: SBO:0000247
has only substance units: false
is: CHEBI:28774
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
type: Species
name: reverse-triiodthyronine
initial amount: NaN
initial concentration: 1.0

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM ksi deg5 l
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
constant: false
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 5
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11

metaM gua c
type: Species
is: SBO:0000247
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: Guanine
is: C00242
is: HMDB00132

metaR r0226
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
fast: false
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

metaM r5p c
type: Species
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: HMDB00618
initial concentration: 1.0
has only substance units: false
is: CHEBI:18189
name: alpha-D-Ribose 5-phosphate
constant: false
boundary condition: false
is: C00117
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_d95d4dd4_a589_49b5_893b_9a7202d1cbaa
constant: false
initial concentration: NaN
name: HIBADH
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:11112
is: P31937
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_78b9a4a0_cf55_43aa_b3c0_4e465b63fdf4
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFB2
is: H7C5B8
is encoded by: hsa:4708
initial amount: NaN
constant: false

metaM 56dura c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15901
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
name: 5,6-dihydrouracil
is: HMDB00076

http://identifiers.org/biomodels.db/MODEL1310110032#_7d82bf5b_2095_4d53_acd2_723fe4a12bdf
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ATP2B4
initial concentration: NaN
has only substance units: false
is: P23634
is encoded by: hsa:493

metaR r0644
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
reversible: true
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_30f6377c_0dc6_4941_8a27_c90f383a0fce
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: LDHB
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: P07195
is encoded by: hsa:3945

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2e4ddbf3_18dc_4e57_bc1a_2e3e23775da5
initial concentration: NaN
name: SCD5
is: Q86SK9
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:79966

metaR DUTPDPn
type: Reaction
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.23
is described by: ECO:0000269
reversible: false
name: dUTP diphosphatase, nuclear
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reactant: MODEL1310110032#

metaR CYTK8
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110032#
is: SBO:0000176
name: cytidylate kinase (CMP,dATP)
reversible: true
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110032#

metaR GLYSNAT5tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM gtp m
constant: false
boundary condition: false
is: CHEBI:37565
initial amount: NaN
name: GTP
type: Species
is: C00044
is: HMDB01273
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f9db0892_6f57_4176_bce9_f080d4159e4c
boundary condition: true
has only substance units: false
is encoded by: hsa:9061
name: PAPSS1
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: O43252
initial amount: NaN

metaM tag hs e
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
is: CHEBI:17855
is: SBO:0000247

metaR NDP8
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_9d6b1827_4661_43a0_a017_5c618a3aa20e
name: RDH14
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q9HBH5
is encoded by: hsa:57665
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_07bcfd2b_5363_4a16_ab86_a23e08bab9f2
is encoded by: hsa:4712
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: O95139
name: NDUFB6
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_afbaf44e_9ca1_42d4_9173_9573a763745f
is: SBO:0000252
is: Q7GXY9
name: ND2
type: Species
is encoded by: hsa:4536
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_5c123a4d_721b_4004_94af_1ea53cccc777
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4707
type: Species
is: SBO:0000252
name: NDUFB1
is: O75438
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_67a29b6e_4e1a_46b2_941a_f05ca036314b
is: SBO:0000252
is: O60760
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:27306
name: HPGDS
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5ecacf7c_9a3b_482c_81fb_7e3b757b2423
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:155184
is: Q6PXP3
type: Species
name: SLC2A7
constant: false
has only substance units: false

metaM dhap c
is: C00111
constant: false
initial amount: NaN
has only substance units: false
name: Dihydroxyacetone phosphate
is: CHEBI:57642
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01473

metaR r0377
is version of: http://identifiers.org/ec-code/2.7.4.3
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_ae8f1319_ae41_49c8_80fb_10e18e23f159
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR FK
product: MODEL1310110032#
name: Fucokinase
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.52
reactant: MODEL1310110032#
type: Reaction

metaM ksi deg36 l
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
constant: false
name: keratan sulfate I, degradation product 36
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
boundary condition: false

metaR 4NPHte
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110032#
is: SBO:0000185
name: xenobiotic transport
reversible: true
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#

metaR CYTK5
name: cytidylate kinase (dCMP)
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_ccf727a1_7e82_478c_935e_55158d5a3482
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:3948
has only substance units: false
is: P07864
name: LDHC
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_e2e9e55a_f4b8_4761_96e1_0915d11b1f51
is: SBO:0000252
type: Species
is: Q9NS18
is encoded by: hsa:51022
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: GLRX2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_69f13ccf_75e6_410c_ae88_126d49dae10a
initial amount: NaN
boundary condition: true
type: Species
is: Q9HAS3
name: SLC28A3
is encoded by: hsa:64078
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM 3mob m
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
has only substance units: false
name: 3-methyl-2-oxobutanoate
type: Species
is: CHEBI:11851
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_dab054c6_5b44_4c39_b1e5_7dd344d57b9f
constant: false
is: Q14916
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC17A1
initial concentration: NaN
is encoded by: hsa:6568

metaR ALOX5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
fast: false
name: Arachidonate 5-lipoxygenase
kinetic law: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe

metaM gua e
is: CHEBI:16235
boundary condition: false
initial concentration: 1.0
name: guanine
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00132
constant: false

metaM ppa c
type: Species
name: propionate
constant: false
is: HMDB00237
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17272
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_45288f9f_00c0_4af4_b98a_cf00a43e8486
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: HAS1
has only substance units: false
is: Q8IYH3
type: Species
is encoded by: hsa:3036
is: SBO:0000252

metaM sphgn c
is: HMDB00269
type: Species
boundary condition: false
has only substance units: false
name: sphinganine(1+)
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_53d34385_9971_4bf7_9688_df42e580f01b
boundary condition: true
is: SBO:0000252
name: SULT1A1
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6817
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_bb683365_009d_4923_b4c4_97bc72e38cef
is encoded by: hsa:955
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: ENTPD6
is: O75354
initial concentration: NaN
is: SBO:0000252

metaM ptth m
is: CHEBI:16753
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
is: HMDB03426
boundary condition: false
initial amount: NaN
constant: false
name: pantetheine

http://identifiers.org/biomodels.db/MODEL1310110032#_1b02886a_8185_43e9_91b3_30b2c2813f36
is: P09972
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:230
is: SBO:0000252
has only substance units: false
name: ALDOC
type: Species
initial concentration: NaN

metaR ACACT10m
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
kinetic law: MODEL1310110032#
fast: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176

metaR CYTK6
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#

metaM tag hs c
name: triglyceride
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17855
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species

metaR THYMt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
name: thymine reversible transport via facilated diffusion
type: Reaction
is described by: ECO:0000269

metaR ALR2
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: aldose reductase (methylglyoxal)
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_33d7f2f9_e04e_46cb_a0d9_290609e77bd2
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5052
initial concentration: NaN
initial amount: NaN
name: PRDX1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fd72d388_cc58_4cd6_997b_4da88e38e105
is: SBO:0000252
constant: false
name: RRM1
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6240
type: Species
is: P23921
initial amount: NaN

metaR C14STRr
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reversible: false
is described by: ECO:0000134
name: C-14 sterol reductase
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM chsterol r
is: HMDB00067
initial amount: NaN
initial concentration: 1.0
name: cholesterol
has only substance units: false
is: CHEBI:16113
boundary condition: false
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_732f1d11_fd24_4953_9b9e_fbb4d2192ffe
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:64834
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: ELOVL1
is: Q9BW60

http://identifiers.org/biomodels.db/MODEL1310110032#_28ee5040_f4a3_44e1_95c9_ba4ce50d2524
name: HIBCH
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: Q6NVY1
is: SBO:0000252
type: Species
is encoded by: hsa:26275

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
initial concentration: 1.0
is: HMDB00224
is: SBO:0000247
type: Species
is: CHEBI:58190
name: O-phosphonatoethanaminium(1-)
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_c5f5c3bf_ccab_46ce_bdbf_84935ca22a27
initial concentration: NaN
constant: false
name: _AI769281_1_e
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI769281
initial amount: NaN
has only substance units: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR CYTK3n
is: SBO:0000176
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110032#
fast: false
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR PAIL HStn
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_44394e1b_5821_46ff_b09f_aadfcd529246
is: O00624
is encoded by: hsa:10246
constant: false
name: SLC17A2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR ALR3
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: aldose reductase (acetol)
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaM ocdca c
is: HMDB00827
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:25629

metaR PROSTGF2t
modifier: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
is: SBO:0000185
name: prostaglandin uniport
fast: false
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_87451f9b_eb81_42ea_ad2f_ee9e262791be
type: Species
name: DCK
is: SBO:0000252
initial amount: NaN
constant: false
is: P27707
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1633
boundary condition: true

metaM ppa e
constant: false
is: HMDB00237
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17272
type: Species
boundary condition: false

metaR NDPK3n
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: true

metaR UDPACGALtl
fast: false
product: MODEL1310110032#
reversible: true
is: SBO:0000185
type: Reaction
name: udpacgal intracellular transport
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaR CYTK3
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (CMP)(GTP)
kinetic law: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#

metaR r0580
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false

metaM atp x
type: Species
constant: false
is: HMDB00538
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: ATP(4-)
is: C00002
is: CHEBI:57299

metaR r1658
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#

metaM amet m
type: Species
is: SBO:0000247
is: HMDB01185
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
has only substance units: false
name: S-Adenosyl-L-methionine
is: C00019
boundary condition: false

metaR DAGt
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110032#
name: diacylglycerol transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_46b9a958_c711_4ed8_b2d9_388613d58604
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:80201
is: B3KT70
has only substance units: false
constant: false
name: HKDC1

metaM 7dhf e
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: heptaglutamyl folate (DHF)
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: HMDB06559
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_7c9338bf_7ac2_4619_8b0d_3cb9cfff8b27
name: CTH
is: SBO:0000252
is: P32929
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:1491

metaM q10 c
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: ubiquinone-10
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072

metaM cytd c
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
constant: false
initial amount: NaN
is: HMDB00089
is: SBO:0000247
is: C00475
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Cytidine

metaM ksi deg15 l
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
name: keratan sulfate I, degradation product 15
boundary condition: false

metaM HC02208 e
type: Species
initial concentration: 1.0
is: CHEBI:27696
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-d1
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110032#_a94da1fd_3d4c_471b_9230_fea008560476
is: O75489
initial concentration: NaN
type: Species
has only substance units: false
name: NDUFS3
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4722
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_0799265e_3ac0_4a8b_a731_b763b79894a3
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false

metaR CYTK4
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
name: cytidylate kinase (dCMP)(GTP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000269

metaM adn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00050
name: Adenosine
boundary condition: false
is: C00212
is: CHEBI:16335

http://identifiers.org/biomodels.db/MODEL1310110032#_2c797e97_2b30_4616_883b_5c6630b86c96
is: E5KNH5
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: NDUFV1
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4723
initial concentration: NaN

metaR r1659
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110032#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_23730cb0_c38a_4590_bed0_89baa2be4de5
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q96CA6
is encoded by: hsa:30
initial amount: NaN
name: ACAA1
type: Species

metaR PROt4 2 r
is: SBO:0000185
name: Proline transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000006
reversible: true
kinetic law: MODEL1310110032#

metaR r0641
is described by: ECO:0000000
fast: false
modifier: MODEL1310110032#
is: SBO:0000176
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#

metaR DESAT18 5
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: false
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_dc61a9cd_d932_4d69_84a1_da685688646e
initial amount: NaN
boundary condition: true
is: O95139
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: NDUFB6
is encoded by: hsa:4712

metaM chsterol l
is: HMDB00067
name: cholesterol
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16113
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaM 3hpcoa m
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58528
is: HMDB06807
type: Species
name: 3-hydroxypropanoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668

http://identifiers.org/biomodels.db/MODEL1310110032#_f524422d_26ca_4647_9fdd_5d5272ca0645
is: O43570
constant: false
is encoded by: hsa:771
boundary condition: true
name: CA12
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaR 3MOBt2im
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110032#_ce9109da_ca5b_400f_83d4_3cdd9798a070
has only substance units: false
name: _AI222095_1_m
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI222095
constant: false

metaM dhap e
name: glycerone phosphate(2-)
boundary condition: false
is: CHEBI:57642
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01473
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
constant: false

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00827
type: Species
name: octadecanoate (n-C18:0)
is: CHEBI:25629
is: C01530

metaM gtp n
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
boundary condition: false
is: CHEBI:37565
is: HMDB01273
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
product: MODEL1310110032#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: mesaconate--CoA ligase (GDP-forming)
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF

metaR CYTK1
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
name: cytidylate kinase (CMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_fbce9818_cbe5_41ba_b5f1_f15c6c1af7a9
has only substance units: false
is encoded by: hsa:65010
initial amount: NaN
is: Q9NQU1
initial concentration: NaN
name: SLC26A6
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_0f1343bf_b037_4ff1_a82c_670f9601da92
is: Q9H6R3
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:79611
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: ACSS3

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a65c83fe_6e89_4350_8bc4_1dadfabd2ba6
is: SBO:0000252
is encoded by: hsa:2678
initial concentration: NaN
initial amount: NaN
name: GGT1
constant: false
is: P19440
boundary condition: true
has only substance units: false
type: Species

metaR r2514
type: Reaction
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110032#
reversible: true
name: Utilized transport
product: MODEL1310110032#

metaM HC01397 x
constant: false
initial amount: NaN
is: CHEBI:27402
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0

metaR r0642
reversible: true
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110032#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_df312b5d_3ce4_4dce_8d69_f90992c1a52e
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: SLC22A2
is: O15244
is encoded by: hsa:6582
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1656
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000

metaR LEUKTRE4t
fast: false
type: Reaction
name: leukotriene E4 transport
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_49fc688a_cd8a_4fe3_bdd9_ae0b69fb0103
boundary condition: true
name: ENTPD2
has only substance units: false
is encoded by: hsa:954
initial concentration: NaN
type: Species
is: Q5SPY7
initial amount: NaN
constant: false
is: SBO:0000252

metaM chsterol m
constant: false
has only substance units: false
is: HMDB00067
initial amount: NaN
name: cholesterol
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
is: CHEBI:16113
initial concentration: 1.0

metaR r2378
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110032#
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f129e290_a1e3_46b4_a8d4_74860bfcec17
is encoded by: hsa:114805
constant: false
type: Species
initial concentration: NaN
name: GALNT13
boundary condition: true
is: Q8IUC8
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM adn c
is: CHEBI:16335
is: HMDB00050
name: Adenosine
is: SBO:0000247
type: Species
boundary condition: false
is: C00212
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
has only substance units: false
constant: false

metaR NDPK3m
modifier: MODEL1310110032#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
is described by: ECO:0000254
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR r2377
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
product: MODEL1310110032#
is described by: ECO:0000000

metaR DNDPt9m
modifier: MODEL1310110032#
name: dADP transport via dTDP antiport
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM udp c
is: HMDB00295
name: UDP
has only substance units: false
constant: false
is: CHEBI:58223
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00015
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_49c8da00_7cf9_4d1f_9c42_8c627d78aee9
has only substance units: false
constant: false
name: PIP5K1C
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:23396
boundary condition: true
is: SBO:0000252
is: O60331

metaR CYTK2
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110032#
modifier: MODEL1310110032#

metaR HDCAtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000

metaM tyr L e
initial concentration: 1.0
has only substance units: false
is: CHEBI:17895
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: SBO:0000247
constant: false
name: L-tyrosine
type: Species
is: HMDB00158

metaR r1657
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110032#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
fast: false

metaM cdp n
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58069
type: Species
is: HMDB01546
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaM paps c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
has only substance units: false
boundary condition: false
is: HMDB01134
initial amount: NaN

metaM acgam6p c
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
initial concentration: 1.0

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM CE2421 m
has only substance units: false
name: (3S)-3-hydroxylinoleoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30623
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: HMDB02329
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1988f7f2_bde3_4849_8157_63a8540127e8
type: Species
initial concentration: NaN
is: Q9NRA2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC17A5
is encoded by: hsa:26503
constant: false

metaM ksi deg9 l
has only substance units: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 9
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial amount: NaN
type: Species
constant: false
is: HMDB00143

metaR r1935
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR A4GALTg
fast: false
kinetic law: MODEL1310110032#
name: Lactosylceramide 4-alpha-galactosyltransferase
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.228
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ

http://identifiers.org/biomodels.db/MODEL1310110032#_20a25175_2661_4e61_aea8_c00b7da2a1b3
is: Q76EJ3
initial concentration: NaN
is encoded by: hsa:11046
type: Species
initial amount: NaN
name: SLC35D2
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR HEXDIACTD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM hco3 m
is: C00288
initial amount: NaN
is: SBO:0000247
name: Bicarbonate
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
is: CHEBI:17544
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR RE1897C
name: RE1897
kinetic law: MODEL1310110032#
fast: false
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
reversible: true

metaM L2aadp c
initial concentration: 1.0
constant: false
is: HMDB00510
is: CHEBI:58672
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
type: Species
has only substance units: false
name: L-2-aminoadipate(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8afb467f_903a_4cb4_a98c_33032bbb3cc1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q96QE2
type: Species
is encoded by: hsa:114134
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC2A13

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_04030f96_2db2_42f3_88a2_525742790166
boundary condition: true
name: CA5B
is encoded by: hsa:11238
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: Q9Y2D0
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_fb9af985_90f4_4e02_8873_e12a4b62a28a
name: ACAT2
is encoded by: hsa:39
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9BWD1
has only substance units: false
constant: false

metaR RE3241R
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reversible: false
name: RE3241
modifier: MODEL1310110032#
fast: false
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaM glu5sa c
type: Species
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
initial concentration: 1.0
is: C01165
name: L-Glutamate 5-semialdehyde
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02104
is: CHEBI:17232
constant: false

metaM C02528 r
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
is: HMDB00518
name: chenodeoxycholate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_a830c633_cca3_4e38_ab55_cf290977f976
is: P05091
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:217
constant: false
name: ALDH2
is: SBO:0000252

metaM 4mop c
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17865
is: HMDB00695

metaR r2318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_53faf4c2_bd09_4ef3_b3fa_67a066f658a9
is encoded by: hsa:2194
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P49327
name: FASN

metaM nadp m
boundary condition: false
is: HMDB00217
has only substance units: false
constant: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
initial amount: NaN

metaR ENGASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110032#
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110032#

metaM urate x
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00289
initial amount: NaN
name: Urate
is: CHEBI:17775
is: C00366
type: Species
has only substance units: false

metaM prpp e
is: HMDB00280
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
initial concentration: 1.0
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58017
boundary condition: false

metaM cmpacna g
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01176
is: SBO:0000247

metaM 1pyr5c m
is: C03912
is: HMDB01301
has only substance units: false
constant: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
boundary condition: false
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
initial amount: NaN
is: CHEBI:15893
initial concentration: 1.0

metaR GALNTg
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.41
is: SBO:0000176
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR NACHEX27ly
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000269
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_814ab6dd_1074_4d0f_b7b9_d6786e42b651
is: Q9Y259
initial amount: NaN
is encoded by: hsa:1120
name: CHKB
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR UGCG
reversible: false
modifier: MODEL1310110032#
name: Ceramide glucosyltransferase
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.80
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaR r1684
name: Y+LAT2 Utilized transport
modifier: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
is: SBO:0000185

metaR MALTSULtm
name: Malate:thiosulfate antiport, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
modifier: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_fa109334_149e_4801_85a6_ba514198baa4
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: COX7A2L
initial amount: NaN
is encoded by: hsa:9167
is: Q6FGA0
type: Species
has only substance units: false

metaM CE5160 r
constant: false
initial concentration: 1.0
is: CHEBI:12947
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA

metaM ump c
is: HMDB00288
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: C00105
name: UMP
constant: false
is: SBO:0000247
is: CHEBI:57865
boundary condition: false

metaR GTHOm
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000254
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110032#

metaM dhf m
type: Species
name: dihydrofolate(2-)
is: SBO:0000247
is: CHEBI:57451
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
initial concentration: 1.0

metaR SPHK21c
product: MODEL1310110032#
name: sphingosine kinase 2
is: SBO:0000176
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.91
fast: false
reactant: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR FAOXC2252053m
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
name: Beta oxidation of long chain fatty acid

metaR PROSTGE2t2
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
product: MODEL1310110032#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110032#

metaM ctp n
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
boundary condition: false
is: CHEBI:37563
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00082
is: SBO:0000247
type: Species

metaR r2317
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR 25HVITD3tin
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
name: 25-hydroxyvitamin D3 transport in cytoplasm
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction

metaM ha e
boundary condition: false
name: hyaluronan
has only substance units: false
is: CHEBI:16336
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species

metaR r1365
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: Vesicular transport
type: Reaction
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_bef3820f_617e_44f7_93bd_a2fd0f41956c
type: Species
is encoded by: hsa:8790
has only substance units: false
boundary condition: true
initial amount: NaN
is: O14772
initial concentration: NaN
name: FPGT
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8d01a691_1639_4306_a682_1a22ed07b1ad
has only substance units: false
name: RDH5
type: Species
initial amount: NaN
constant: false
is: Q92781
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5959

metaR GluForTx
fast: false
is described by: ECO:0000269
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
name: Glutamate formimidoyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.5
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction

metaM galgluside hs g
type: Species
initial concentration: 1.0
name: galactosyl glucosyl ceramide
has only substance units: false
constant: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
boundary condition: false
is: C00015
is: HMDB00295
initial amount: NaN
is: CHEBI:58223

metaM cs a deg5 l
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15936
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false

metaR GALt1r
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
reversible: true
product: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
name: galactose transport (uniport)

metaR ARACHCPT1
fast: false
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
modifier: MODEL1310110032#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR B MANNASEly
type: Reaction
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
fast: false
modifier: MODEL1310110032#
name: beta-mannosidase, lysosomal
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.25
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaR SPH1Pte
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
fast: false
name: sph1p transport
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_4977f522_ae02_41d1_9e03_05c0295e8c78
has only substance units: false
is encoded by: hsa:38
constant: false
boundary condition: true
name: ACAT1
initial amount: NaN
type: Species
is: SBO:0000252
is: P24752
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2ae6dab2_945b_41c3_af5f_c4022b0ab15e
is: P51570
type: Species
is encoded by: hsa:2584
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: GALK1
initial concentration: NaN

metaM arg L e
boundary condition: false
initial concentration: 1.0
name: L-argininium(1+)
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00517
is: CHEBI:32682
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN

metaM Rtotalcoa c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
is: HMDB01448
is: SBO:0000247
has only substance units: false
name: R total Coenzyme A
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5925805e_cbb4_4d3c_975c_84492ab9e2c0
is: SBO:0000252
type: Species
name: ACOX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
boundary condition: true
initial amount: NaN
constant: false
is: B4DK61

metaM prpp c
is: HMDB00280
type: Species
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: C00119
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58017
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_48c010e2_feb3_47c1_8a81_9823eafd19e4
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3034
boundary condition: true
has only substance units: false
is: B4E0V8
constant: false
name: HAL

metaR r0870
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.4.13
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#

metaM acngalgbside hs g
name: sialyl galactosylgloboside
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03406
boundary condition: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: SBO:0000247
is: CHEBI:16523
initial amount: NaN

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR NADH2 u10m
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
name: NADH dehydrogenase, mitochondrial
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3

metaR FRUt4
name: D-fructose transport via sodium cotransport
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000269

metaM arg L c
initial amount: NaN
constant: false
name: L-argininium(1+)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:32682
boundary condition: false
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517

http://identifiers.org/biomodels.db/MODEL1310110032#_b7fdc8cd_1e60_4449_80c5_fa1dbb1b36fb
initial concentration: NaN
name: _22305_1_c
has only substance units: false
constant: false
is encoded by: hsa:22305
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaM gluside hs g
is: CHEBI:18368
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
name: D-glucosyl-N-acylsphingosine
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
type: Reaction
kinetic law: MODEL1310110032#
reversible: true

metaR RE3520E
product: MODEL1310110032#
name: RE3520
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
modifier: MODEL1310110032#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9

metaR ACGAMtly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f3cee7e7_1f92_46c3_8535_7b221b374383
boundary condition: true
name: ST20
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9HBF5
constant: false
is encoded by: hsa:400410
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_eaf41ced_0924_4f74_9888_e2f3db1f1731
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q6LEN5
name: CHAT
type: Species
constant: false
is encoded by: hsa:1103
initial concentration: NaN

metaR r2319
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185

metaR ARACHCPT2
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110032#
name: carnitine transferase
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#

metaR DNDPt26m
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110032#
reversible: false
is: SBO:0000185
name: dCDP transport via dUDP antiport

metaM CE5121 m
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
is: CHEBI:57449
constant: false
is: SBO:0000247
boundary condition: false
name: trans-3-decenoyl-CoA

metaM HC01223 m
is: CHEBI:57340
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
has only substance units: false
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0

metaM occoa m
is: HMDB01070
boundary condition: false
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57386
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)

metaR 2OXOADOXm
modifier: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.61
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110032#
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_c20529fe_a45e_4e48_84c7_c94115fe96b7
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AI620219
initial concentration: NaN
name: _AI620219_1_e

metaR G6PPer
name: glucose-6-phosphate phosphatase, edoplasmic reticular
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.9
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_73a36f66_111a_47ef_8c0e_f7f3a2f324d2
boundary condition: true
has only substance units: false
initial amount: NaN
name: PLCB4
is encoded by: hsa:5332
is: Q15147
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_b1a22402_46aa_4ca0_b840_c57444918e46
boundary condition: true
name: ALDH1B1
type: Species
is: P30837
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:219
initial concentration: NaN

metaR LPS
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.34
modifier: MODEL1310110032#
is described by: ECO:0000000
name: lipase
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#

metaR HACD1m
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110032#
modifier: MODEL1310110032#

metaM malttr e
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial concentration: 1.0
is: SBO:0000247
name: maltotriose
boundary condition: false
is: CHEBI:27931
is: HMDB01262
constant: false
is: C01835
initial amount: NaN
has only substance units: false

metaM g6p r
name: D-Glucose 6-phosphate
type: Species
initial amount: NaN
is: C00092
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:61548
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401

http://identifiers.org/biomodels.db/MODEL1310110032#_87edabe4_a10e_45bd_ad60_422a986da148
has only substance units: false
initial amount: NaN
is: Q9HC58
type: Species
is encoded by: hsa:57419
is: SBO:0000252
initial concentration: NaN
constant: false
name: SLC24A3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_b70b1c8d_5be4_4b4c_bdf7_0a863d721430
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AI653169_1_c
type: Species
is encoded by: hsa:AI653169
constant: false
boundary condition: true
is: SBO:0000252

metaM 3sala c
boundary condition: false
is: C00606
type: Species
name: 3-Sulfino-L-alanine
is: CHEBI:61085
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaR AICART
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110032#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reversible: true

metaR GLCAASE8ly
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b968da5c_e57d_45ac_927c_0d0b81086b98
boundary condition: true
is: P22680
is encoded by: hsa:1581
initial amount: NaN
type: Species
is: SBO:0000252
name: CYP7A1
has only substance units: false
constant: false
initial concentration: NaN

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR PRPPS
product: MODEL1310110032#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
modifier: MODEL1310110032#
reactant: MODEL1310110032#

metaM bamppald c
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
name: beta-Aminopropion aldehyde
boundary condition: false
initial amount: NaN
is: C05665
constant: false
has only substance units: false
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975

metaR r0651
reversible: true
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_76e16b3b_c3cd_4760_bd4e_e17b6e3e77a9
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: SLCO2A1
constant: false
is encoded by: hsa:6578
is: Q92959

metaM CE2417 m
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
boundary condition: false
is: CHEBI:28387
initial amount: NaN
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
constant: false

metaR r2314
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9331d04d_db04_4367_884d_0ffa6b357a63
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3162
is: SBO:0000252
is: Q6FH11
name: HMOX1
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM nmn c
is: SBO:0000247
name: NMN
is: C00455
initial concentration: 1.0
constant: false
is: CHEBI:14649
type: Species
boundary condition: false
has only substance units: false
is: HMDB00229
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455

http://identifiers.org/biomodels.db/MODEL1310110032#_4541da57_8c1f_40c6_8cdc_fad88f38b909
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:115286
initial concentration: NaN
boundary condition: true
name: SLC25A26

http://identifiers.org/biomodels.db/MODEL1310110032#_0de79b77_3bf1_4bb0_8e2e_cc3f591c628a
has only substance units: false
constant: false
is encoded by: hsa:412
name: STS
type: Species
boundary condition: true
initial amount: NaN
is: P08842
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_a33a3c06_7876_48d6_9425_33b81b3d3606
type: Species
name: _AI191472_1_c
is encoded by: hsa:AI191472
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaM ump g
type: Species
has only substance units: false
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00288
is: CHEBI:57865
is: SBO:0000247

metaR r0650
modifier: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

metaR RE1903R
type: Reaction
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
name: RE1903
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaR r1364
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Vesicular transport
fast: false
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110032#

metaM HC01115 c
is: SBO:0000247
is: CHEBI:29025
type: Species
constant: false
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: NeuNGc

metaM apoC c
constant: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: HMDB11111
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
is: CHEBI:33190
type: Species
boundary condition: false
is: SBO:0000247

metaM nadp r
is: CHEBI:58349
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
type: Species
constant: false
is: HMDB00217
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
is: SBO:0000247

metaM HC01401 m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
type: Species
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8c14134a_1ebc_47cd_9126_e5ca023d7719
type: Species
name: COX7B
boundary condition: true
is encoded by: hsa:1349
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P24311
is: SBO:0000252
constant: false

metaM f1a l
type: Species
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
name: F1alpha
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17151
is: HMDB02917
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9084768b_265a_49c0_8afc_31127f0fd22e
is: P04746
boundary condition: true
name: AMY2A
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:279

metaM atp e
has only substance units: false
is: HMDB00538
constant: false
name: ATP(4-)
is: C00002
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57299
initial amount: NaN
boundary condition: false

metaR r2313
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR ACACT1x
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110032#
reversible: false

metaR PPAm
reactant: MODEL1310110032#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: inorganic diphosphatase
product: MODEL1310110032#

metaM hmgcoa m
boundary condition: false
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01375

metaR r0276
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is: SBO:0000176
reversible: true

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_ff2f3b57_7530_4759_a56f_2debf1219ee1
name: SULT1A2
boundary condition: true
is: P50226
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:6799
type: Species
initial amount: NaN

metaR AMETtd
is described by: ECO:0000134
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true

metaR NACHEXA9ly
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000

metaM citr L m
has only substance units: false
is: HMDB00904
is: CHEBI:16349
constant: false
type: Species
initial amount: NaN
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_75a9151e_f7d3_44a2_854d_6c19769184c8
boundary condition: true
is: O00217
initial amount: NaN
is encoded by: hsa:4728
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFS8
is: SBO:0000252

metaR URATEt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
fast: false
reactant: MODEL1310110032#

metaR r2316
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110032#_8145bb0d_ab74_4e60_b99a_d0f79d10e98e
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC37A4
boundary condition: true
is encoded by: hsa:2542
initial amount: NaN
has only substance units: false
is: A8K0S7

http://identifiers.org/biomodels.db/MODEL1310110032#_c7d574ac_711d_40e7_96c9_ccc2e1a489da
has only substance units: false
is encoded by: hsa:4514
type: Species
initial concentration: NaN
name: COX3
is: P00414
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_d56dcc8f_64b4_433b_8bfe_1f59131c5895
initial amount: NaN
is: SBO:0000252
is: P35790
is encoded by: hsa:1119
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: CHKA
type: Species

metaM 4mop e
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:17865
initial amount: NaN
is: HMDB00695
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate

metaM 3pg m
constant: false
is: HMDB00807
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:58272
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate

metaR r2420
type: Reaction
product: MODEL1310110032#
fast: false
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_e4fd9749_6980_4e96_bc31_3e621ecf2e8c
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: P49189
has only substance units: false
is encoded by: hsa:223
is: SBO:0000252
constant: false
name: ALDH9A1

metaR PPAn
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
name: inorganic diphosphatase, nuclear
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
is: SBO:0000176

metaR TCHOLAte
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110032#

metaR DSAT
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
fast: false

metaM gdpfuc c
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57984
type: Species
constant: false
name: GDP-L-fucose(2-)
is: HMDB01095

http://identifiers.org/biomodels.db/MODEL1310110032#_6d8cb328_b66d_497c_8278_6c3393340f8b
is: Q5JZF5
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ALAS2
boundary condition: true
is encoded by: hsa:212
initial amount: NaN

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: C04946
is: SBO:0000247
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_f2c6605c_2742_45da_8bd0_e4a5d30ae91e
boundary condition: true
name: MCCC1:MCCC2
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has part: Q9HCC0
is encoded by: hsa:56922
has part: Q96RQ3
type: Species
constant: false
is encoded by: hsa:64087
has only substance units: false

metaM maltpt e
name: maltopentaose
is: SBO:0000247
is: C02052
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB01296
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_83dd7718_d7a8_4e60_a8d9_34014f15fe12
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: NDUFS8
is: O00217
has only substance units: false
is encoded by: hsa:4728
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_e91c00b8_a371_40d8_9454_1662454d53aa
name: _R51273_1_c
is: SBO:0000252
is encoded by: hsa:R51273
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r2315
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110032#
is: SBO:0000185

metaM gluside hs c
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: D-glucosyl-N-acylsphingosine

metaM atp c
is: HMDB00538
constant: false
name: ATP(4-)
initial concentration: 1.0
is: C00002
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:30616

metaM HC02020 r
boundary condition: false
is: SBO:0000247
name: Cholesterol-ester-palm
type: Species
is: CHEBI:3663
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
has only substance units: false

metaR SMPD4
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false
type: Reaction
name: sphingomyelinase
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
is: SBO:0000176

metaM dhf e
is: HMDB01056
has only substance units: false
name: dihydrofolate(2-)
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
is: SBO:0000247
is: CHEBI:57451
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ff0fcc7b_e8f4_4302_b126_94049a97233b
constant: false
has part: P07327
name: ADH1A:ADH1B
initial amount: NaN
has only substance units: false
is: SBO:0000297
initial concentration: NaN
type: Species
is encoded by: hsa:124
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_452df99e_f089_47a5_aeef_20b4dd5a54bf
is: SBO:0000252
is encoded by: hsa:AI926493
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: _AI926493_1_m
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_4afa39bd_8b3a_489b_8699_4bce003e244d
is encoded by: hsa:3938
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: LCT
constant: false
is: P09848
boundary condition: true
initial amount: NaN
type: Species

metaR FAOXC2051843m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

metaM HC01412 m
type: Species
boundary condition: false
is: SBO:0000247
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
constant: false

metaR DURIt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110032#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110032#

metaR r1758
is: SBO:0000185
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
is described by: ECO:0000000

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR GLYSARCNc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_744fb158_e453_468b_88ed_63d5ed9b5dec
initial concentration: NaN
is: P00390
constant: false
boundary condition: true
type: Species
name: GSR
is: SBO:0000252
is encoded by: hsa:2936
has only substance units: false
initial amount: NaN

metaM HC01409 m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:27540
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM leuktrC4 c
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57973
is: HMDB01198
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)

metaR r0391
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000

metaR r2310
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7a83d17b_ea23_48ec_a004_c8dc0868baf7
has only substance units: false
boundary condition: true
name: CYBRD1
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: B4DWD7
is encoded by: hsa:79901

metaM Tn antigen l
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Tn antigen
initial amount: NaN
constant: false
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110032#_f253dcd1_450e_4567_8870_523bc4c3150b
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: _206_1_c
is encoded by: hsa:206
initial amount: NaN
type: Species
has only substance units: false

metaM nad x
is: SBO:0000247
is: HMDB00902
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00003
is: http://identifiers.org/pubchem.compound/3305
constant: false
type: Species
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: CHEBI:57540

metaM ctp e
initial amount: NaN
is: HMDB00082
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
type: Species
is: CHEBI:37563
boundary condition: false
name: CTP(4-)
initial concentration: 1.0

metaR FACOAL140i
product: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: fatty-acid--CoA ligase (tetradecanoate)
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110032#
type: Reaction

metaR PPA
fast: false
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
is: SBO:0000176
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
modifier: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000269

metaR CHSTEROLtrc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
name: transport of cholesterol into the cytosol
reversible: true
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185

metaM glu5sa m
is: C01165
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB02104
is: CHEBI:17232
name: L-Glutamate 5-semialdehyde
initial amount: NaN

metaM acnam l
constant: false
is: SBO:0000247
type: Species
name: N-acetylneuraminate
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial concentration: 1.0
is: CHEBI:35418

http://identifiers.org/biomodels.db/MODEL1310110032#_214a43aa_582e_49a0_b8dc_8546b328fbdc
type: Species
boundary condition: true
name: PEMT
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10400
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_edeba400_ae67_4dfb_8aa0_c7c62080db1d
is: Q8WXF9
constant: false
is: SBO:0000252
name: SLC2A11
boundary condition: true
initial amount: NaN
is encoded by: hsa:66035
has only substance units: false
type: Species
initial concentration: NaN

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.

metaR ADA
type: Reaction
is described by: ECO:0000269
name: Adenosine deaminase
reversible: false
product: MODEL1310110032#
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.4
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR PRAGSr
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
name: phosphoribosylglycinamide synthase

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r0392
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110032#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110032#
type: Reaction

metaM dhf c
name: 7,8-Dihydrofolate
boundary condition: false
is: HMDB01056
is: CHEBI:57451
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00415
constant: false
type: Species
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR r2425
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.16.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
product: MODEL1310110032#
fast: false

metaR r2312
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM 6a2ohxnt x
name: 6-amino-2-oxohexanoic acid
initial concentration: 1.0
is: HMDB12151
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0879
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110032#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_cf6865d4_63d6_4dcb_a936_c0218eedf35c
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PLA2G7
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:7941
is: Q13093

metaR HIBDm
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000269

metaM dgtp c
is: C00286
boundary condition: false
is: HMDB01440
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: dGTP
is: CHEBI:16497
constant: false

metaM ade e
initial concentration: 1.0
has only substance units: false
is: CHEBI:16708
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: adenine
boundary condition: false
is: HMDB00034

http://identifiers.org/biomodels.db/MODEL1310110032#_6a4a3adb_91b4_4367_9904_6de0e5ae14bf
boundary condition: true
type: Species
constant: false
name: ENTPD4
is: Q9Y227
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9583

metaR HIStN1
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
name: Histidine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false

metaR r1156
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

metaM hpyr c
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: CHEBI:17180
name: 3-hydroxypyruvate
is: HMDB01352
has only substance units: false
initial amount: NaN

metaM leuktrC4 e
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: HMDB01198
is: CHEBI:57973
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)

metaM nadp c
initial amount: NaN
is: CHEBI:58349
boundary condition: false
is: SBO:0000247
is: HMDB00217
is: C00006
type: Species
name: Nicotinamide adenine dinucleotide phosphate
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110032#_c1136995_519f_4b38_aebc_3034d2ca3eb2
is: Q6YFQ2
name: COX6B2
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:125965
initial amount: NaN
boundary condition: true

metaR RE1516M
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM 2mbcoa m
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
has only substance units: false
initial amount: NaN
is: HMDB01041
is: SBO:0000247
boundary condition: false
name: 2-methylbutanoyl-CoA(4-)
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_75eaf333_bf3d_4d70_8b54_136d76a52463
boundary condition: true
type: Species
constant: false
name: ADH4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:127
has only substance units: false
is: SBO:0000252
is: P08319

http://identifiers.org/biomodels.db/MODEL1310110032#_56276d28_8e45_46b0_be90_e26adfebeb2b
name: NDUFS4
is: O43181
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4724

metaR THP2Ctp
is described by: ECO:0000000
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_0444d426_4820_4edb_8d02_e954254777d9
is: P14550
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: AKR1A1
is encoded by: hsa:10327
initial concentration: NaN

metaR APOC LYS BTNP
name: proteolysis of apoC-Lys-btn
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR r1759
is described by: ECO:0000000
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false

metaM gdpfuc g
constant: false
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
boundary condition: false
initial amount: NaN
is: HMDB01095
is: CHEBI:57984
name: GDP-L-fucose(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_71bda88d_6c88_4703_9cd8_c109bdbc814e
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: P51687
initial amount: NaN
is encoded by: hsa:6821
initial concentration: NaN
name: SUOX
has only substance units: false

metaM bilglcur r
has only substance units: false
is: CHEBI:57767
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false

metaR CITRtm
type: Reaction
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: citrulline mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_9c7c62e0_5553_4192_990c_8d0b84175439
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
is: P36269
is encoded by: hsa:2687
initial amount: NaN
name: GGT5

metaM dtdp c
initial concentration: 1.0
has only substance units: false
name: dTDP
is: SBO:0000247
boundary condition: false
is: CHEBI:58369
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial amount: NaN
type: Species
is: C00363

metaR r2311
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaR r0390
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction

metaR RE1521M
reactant: MODEL1310110032#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110032#
name: RE1521
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_3eb6b26c_ac8b_426a_aa53_a355bcc42e97
boundary condition: true
is encoded by: hsa:4709
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q6IB80
name: NDUFB3
initial concentration: NaN
has only substance units: false

metaM dhlam m
is: CHEBI:17694
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
type: Species
name: dihydrolipoamide
constant: false
boundary condition: false
is: HMDB00985
has only substance units: false

metaR O2t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
name: o2 transport (diffusion)
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true

metaR GALASE1ly
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reversible: false
modifier: MODEL1310110032#

metaM ade c
has only substance units: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: Adenine
is: C00147
boundary condition: false
is: CHEBI:16708
initial concentration: 1.0
is: HMDB00034
constant: false
type: Species
initial amount: NaN

metaM pail345p hs c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
boundary condition: false
is: CHEBI:57836

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57795
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110032#_eecc1948_0315_4501_86de_e54baa3cd718
is encoded by: hsa:H77542
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: _H77542_1_r

http://identifiers.org/biomodels.db/MODEL1310110032#_e79c632d_521b_451f_8b90_9ab3af13004c
type: Species
boundary condition: true
is encoded by: hsa:4351
initial amount: NaN
initial concentration: NaN
is: P34949
is: SBO:0000252
has only substance units: false
name: MPI
constant: false

metaM thm c
is: C00378
initial amount: NaN
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
is: CHEBI:0
is: HMDB00235
has only substance units: false
is: SBO:0000247
type: Species
name: Thiamin
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_c2939ce4_4e5d_4fcd_bac3_0b18f7d51439
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P11908
type: Species
initial concentration: NaN
is encoded by: hsa:5634
initial amount: NaN
constant: false
name: PRPS2

metaM dgtp e
initial amount: NaN
constant: false
type: Species
is: HMDB01440
initial concentration: 1.0
is: SBO:0000247
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
has only substance units: false
is: CHEBI:16497

http://identifiers.org/biomodels.db/MODEL1310110032#_d75355e8_0ca8_4432_aa62_a5b15c1c0428
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: CHAT
is: SBO:0000252
is encoded by: hsa:1103
is: Q6LEN5
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_3926d9b5_69ee_4c29_9d0b_e3d5922d828f
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B4E097
has only substance units: false
constant: false
is encoded by: hsa:2592
name: GALT
boundary condition: true

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
fast: false
name: Gamma-glutamyltransferase
is: SBO:0000176
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#

metaR r2092
type: Reaction
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM cmpacna c
is: SBO:0000247
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57812
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_d29c8ef5_bdbb_462c_9e44_af583c8854c9
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: O00483
name: NDUFA4
is: SBO:0000252
is encoded by: hsa:4697
constant: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR TRPt
reactant: MODEL1310110032#
fast: false
name: L-tryptophan transport
kinetic law: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110032#
type: Reaction
reversible: true
modifier: MODEL1310110032#

metaR GMPtg
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)

http://identifiers.org/biomodels.db/MODEL1310110032#_09cc74ac_fa19_4f5b_920f_9242d2647dc4
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10637
name: LEFTY1
is: SBO:0000252
boundary condition: true
constant: false
is: O75610

metaR PPCDC
is described by: ECO:0000269
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
name: phosphopantothenoylcysteine decarboxylase
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM HC02121 c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58758
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
constant: false
initial concentration: 1.0
name: S-(hydroxymethyl)glutathione(1-)

http://identifiers.org/biomodels.db/MODEL1310110032#_09ad9af5_8932_493c_89c5_8096e670ac32
constant: false
type: Species
is: SBO:0000252
is: P20933
has only substance units: false
boundary condition: true
is encoded by: hsa:175
name: AGA
initial amount: NaN
initial concentration: NaN

metaR KCCt
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110032#
name: K+-Cl- cotransport

metaM dcsptn1 e
is: http://identifiers.org/pubchem.compound/5282848
is: HMDB13123
boundary condition: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9f1c4e5f_0b5c_409c_b4cb_bfbf376b5fe5
is encoded by: hsa:47
boundary condition: true
name: ACLY
has only substance units: false
type: Species
initial concentration: NaN
is: P53396
initial amount: NaN
constant: false
is: SBO:0000252

metaR 1PPDCRp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
type: Reaction
product: MODEL1310110032#
fast: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110032#

metaR O2tp
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110032#_c5882057_ff00_461a_a426_e340cd1e8cb2
is: O75912
type: Species
boundary condition: true
is encoded by: hsa:9162
name: DGKI
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR ALAt2r
type: Reaction
reactant: MODEL1310110032#
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110032#
is described by: ECO:0000304
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM ump n
is: CHEBI:57865
type: Species
has only substance units: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
constant: false
name: UMP(2-)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_ffc5bd68_c649_4aa9_b0c3_3c9703784dad
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AA977580
has only substance units: false
constant: false
initial concentration: NaN
name: _AA977580_1_c

http://identifiers.org/biomodels.db/MODEL1310110032#_87de289f_459e_464d_b174_a2656bf54b2f
initial amount: NaN
name: CDIPT
is encoded by: hsa:10423
is: SBO:0000252
has only substance units: false
type: Species
is: O14735
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_58e45bfd_416c_44b6_9936_04c8cb769091
name: _AI539321_1_c
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI539321

http://identifiers.org/biomodels.db/MODEL1310110032#_1bf8c952_82cb_4f46_849b_2fdbc462f1a1
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:7084
is: O00142
has only substance units: false
is: SBO:0000252
constant: false
name: TK2

http://identifiers.org/biomodels.db/MODEL1310110032#_d92da1f7_1c9c_40b9_a6d6_9940dac28a2a
name: SLC25A19
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: Q9HC21
has only substance units: false
is encoded by: hsa:60386

metaM 4abut c
is: SBO:0000247
name: 4-Aminobutanoate
constant: false
boundary condition: false
type: Species
is: HMDB00112
is: CHEBI:3628
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
has only substance units: false
initial concentration: 1.0

metaR r2093
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185

metaR q10tm
reactant: MODEL1310110032#
is described by: ECO:0000134
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of ubiquinone into mitochondria
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9037533b_bfec_42a1_955c_c730981059c3
is: SBO:0000297
initial concentration: NaN
has only substance units: false
is encoded by: hsa:126
type: Species
initial amount: NaN
name: ADH1B:ADH1C
constant: false
boundary condition: true
has part: P00326

metaM thr L c
type: Species
boundary condition: false
is: HMDB00167
is: CHEBI:16857
initial amount: NaN
name: L-threonine
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 5adtststerone c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
constant: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR PPAt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
name: Propionate transport, diffusion

metaM hmgcoa x
type: Species
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
is: HMDB01375
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467

http://identifiers.org/biomodels.db/MODEL1310110032#_fef64b0b_551e_48fc_891b_6fc77cff35e1
name: MCCC1
initial concentration: NaN
boundary condition: true
is: Q96RQ3
is encoded by: hsa:56922
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_d381dfdd_1349_4675_8bcd_a6ee4b8f8820
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:1036
is: Q16878
boundary condition: true
type: Species
name: CDO1
initial amount: NaN

metaM atp n
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
is: HMDB00538
is: CHEBI:57299
initial amount: NaN
type: Species
name: ATP(3-)
constant: false
has only substance units: false

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16336
initial amount: NaN
name: hyaluronan

metaM dtdp e
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: HMDB01274
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58369
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9e4ca754_aee9_4d7f_b336_28900a2805a6
constant: false
is encoded by: hsa:1737
is: Q86YI5
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: DLAT

http://identifiers.org/biomodels.db/MODEL1310110032#_8a9bc1be_bfbc_47b5_8850_736a781d5579
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: P53794
is: SBO:0000252
type: Species
is encoded by: hsa:6526
name: SLC5A3

metaM citr L c
name: L-citrulline
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
type: Species
is: HMDB00904
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM 3pg c
initial amount: NaN
initial concentration: 1.0
is: C00197
name: 3-Phospho-D-glycerate
is: SBO:0000247
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
constant: false
has only substance units: false
is: CHEBI:58272
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_67f99db1_720a_4338_aa85_a34383060bcb
type: Species
initial amount: NaN
is encoded by: hsa:10873
has only substance units: false
constant: false
is: Q6TCH8
is: SBO:0000252
initial concentration: NaN
name: ME3
boundary condition: true

metaR r2390
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6761d880_78ca_4d8a_8f43_6c700e739335
is encoded by: hsa:AF080579
boundary condition: true
name: _AF080579_1_c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_81817f34_672b_4b0d_b67f_e18eb6b9b475
constant: false
is encoded by: hsa:766
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: CA7
is: Q86YU0
initial amount: NaN

metaR SUCCtp
name: succinate transporter, peroxisome
type: Reaction
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185

metaR O2tm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reversible: true
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: O2 transport (diffusion)
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_d7b5d984_2a70_4ecd_b784_35cad7500417
initial amount: NaN
is encoded by: hsa:347734
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: SLC35B2
has only substance units: false
is: Q8TB61

metaR FACOAL2251
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110032#
name: fatty-acid--CoA ligase
reversible: true
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#

metaR r2090
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110032#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#

metaR GCC2am
product: MODEL1310110032#
name: glycine-cleavage complex (lipoamide), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR PRFGS
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110032#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.5.3
name: phosphoribosylformylglycinamidine synthase

metaR MCDm
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.9
name: Malonyl-CoA Decarboxylase, mitochondrial
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.1.1.9 Confidence Level: 4 AUTHORS: PMID:12123667,PMID:12955715 NOTES:TDV (9/14/2004) added "m" to denote compartmentalization - NCD
is described by: ECO:0000269
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM ctp m
is: CHEBI:37563
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00082
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
has only substance units: false
constant: false

metaM atp m
is: CHEBI:57299
initial concentration: 1.0
name: ATP(4-)
has only substance units: false
constant: false
is: C00002
is: SBO:0000247
is: HMDB00538
initial amount: NaN
type: Species
boundary condition: false

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_502e059d_9597_4d77_8383_748644f358fa
type: Species
constant: false
has only substance units: false
is: Q9NX14
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54539
initial amount: NaN
name: NDUFB11
initial concentration: NaN

metaM dcsptn1 c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
has only substance units: false
is: HMDB13123
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaM HC01602 c
is: SBO:0000247
boundary condition: false
is: CHEBI:57454
has only substance units: false
initial amount: NaN
constant: false
name: 10-Formyltetrahydrofolate
type: Species
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_3c326481_8d0d_4257_9135_4d39aed89596
has only substance units: false
initial amount: NaN
constant: false
name: ALDH1B1
is encoded by: hsa:219
is: P30837
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_67d48d3e_6e60_4af2_9a81_562f7feabf0c
has only substance units: false
is: Q1LZ56
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:206358
name: SLC36A1
constant: false
initial amount: NaN
type: Species

metaM thr L e
constant: false
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
type: Species
name: L-threonine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16857
is: HMDB00167
initial amount: NaN

metaM glyc m
has only substance units: false
constant: false
boundary condition: false
name: Glycerol
is: CHEBI:17754
is: HMDB00131
type: Species
is: C00116
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN

metaM Sfglutth c
is: HMDB01550
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false
is: CHEBI:57688
name: S-formylglutathionate(1-)
type: Species

metaR r2091
is: SBO:0000185
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110032#_f46f13a3_a186_4ccd_95b1_84d9037928bb
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: GGT2
is encoded by: hsa:728441
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_61f9546a_fddf_42a2_803d_f215e958434d
is: Q99624
is encoded by: hsa:10991
constant: false
type: Species
has only substance units: false
name: SLC38A3
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR ASNt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
kinetic law: MODEL1310110032#
reversible: false
type: Reaction
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
name: L-asparagine transport in via sodium symport

metaM 4abut e
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
boundary condition: false
is: C00334
type: Species
is: CHEBI:3628
name: 4-Aminobutanoate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d9240c71_f3d6_4157_9899_cc556e93c74a
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6569
has only substance units: false
is: Q7Z725
initial concentration: NaN
name: SLC34A1
type: Species
initial amount: NaN

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r0051
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

http://identifiers.org/biomodels.db/MODEL1310110032#_44734785_c49c_4049_94b3_8e94ba9bdd50
name: NME1:NME2
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297
type: Species
is encoded by: hsa:4830
constant: false
initial concentration: NaN

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r2392
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaR PROSTGD2t
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reversible: true

metaM citr L e
has only substance units: false
name: citr_L[e]
is: HMDB00904
is: CHEBI:16349
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR KHte
reactant: MODEL1310110032#
name: KHte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
fast: false

metaR Coqe
fast: false
name: Transport of q10
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000134
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_92d1aeee_af16_4508_a208_00ccb35ee685
boundary condition: true
type: Species
initial concentration: NaN
name: SLC25A20
is encoded by: hsa:788
initial amount: NaN
is: SBO:0000252
is: O43772
constant: false
has only substance units: false

metaM aacoa x
boundary condition: false
is: CHEBI:57286
is: HMDB01484
name: acetoacetyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM gdpmann c
is: SBO:0000247
name: GDP-alpha-D-mannose(2-)
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial concentration: 1.0
constant: false
is: HMDB01163
is: CHEBI:57527
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaM mescoa m
boundary condition: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: CHEBI:27969
type: Species
is: SBO:0000247
is: C06028
name: Mesaconyl-CoA
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR CO2t
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reactant: MODEL1310110032#
is: SBO:0000185
name: CO2 transporter via diffusion

http://identifiers.org/biomodels.db/MODEL1310110032#_6b351369_dacf_4432_ac1a_1659a85d19e9
initial concentration: NaN
initial amount: NaN
constant: false
name: SPTLC2
is: SBO:0000252
is encoded by: hsa:9517
type: Species
has only substance units: false
is: O15270
boundary condition: true

metaR CRNt
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110032#
name: L-carnitine reversible transport
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_c4c4ef38_9c2f_44ea_9f96_f2f5024a1e9f
initial concentration: NaN
is: SBO:0000252
name: PPAP2C
type: Species
is: E9PAY8
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8612
initial amount: NaN

metaM malcoa c
initial amount: NaN
name: Malonyl-CoA
is: SBO:0000247
is: HMDB01175
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57384
is: C00083
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_3b19b4f7_af00_43e7_8073_1415dea4dc9b
boundary condition: true
name: NDUFS7
initial amount: NaN
initial concentration: NaN
is: O75251
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:374291

metaR r2097
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false

metaR RE3567C
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
name: RE3567
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8220cdac_0450_4aac_a7d9_2776996999cd
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: IDH1
is: O75874
is encoded by: hsa:3417
type: Species

metaR r1750
reversible: false
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR SERDGLYexR
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000304
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_027ac380_423c_4576_a2d8_9d468c9f1328
is encoded by: hsa:T83654
name: _T83654_1_c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM 1pipdn2c x
type: Species
initial concentration: 1.0
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
is: HMDB01084
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 1-piperideine-2-carboxylate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_335fed4c_b2fb_48aa_a897_10ba5af02339
initial concentration: NaN
name: NDUFS2
is encoded by: hsa:4720
initial amount: NaN
has only substance units: false
is: B7Z792
constant: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_f4681535_c045_4e0b_87fb_d10e0f8545ae
initial amount: NaN
is encoded by: hsa:1376
boundary condition: true
has only substance units: false
is: P23786
type: Species
name: CPT2
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r1162
fast: false
reversible: false
name: Active transport
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
product: MODEL1310110032#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR PETOHMr hs
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
modifier: MODEL1310110032#
name: phosphatidylethanolamine N-methyltransferase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_57d7caac_6c7a_46d8_89eb_0893fe4f9e9a
initial amount: NaN
name: CYP51A1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1595
is: Q16850
type: Species

metaR CITL
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
is: SBO:0000176
modifier: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
name: Citrate lyase

http://identifiers.org/biomodels.db/MODEL1310110032#_26fd5008_1acb_4dcd_aa89_73e3ae37effd
name: IVD
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:3712
is: B3KVI7
initial concentration: NaN
constant: false
type: Species

metaR SERGLYexR
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
fast: false
name: L-Serine/Glycine reversible exchange
kinetic law: MODEL1310110032#

metaR ADKd
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110032#
name: adenylate kinase (d form)
type: Reaction
reversible: true
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8944ef3a_15eb_409e_b51a_da5d84cc60ee
type: Species
is encoded by: hsa:2525
has only substance units: false
boundary condition: true
is: P21217
initial amount: NaN
name: FUT3
initial concentration: NaN
constant: false
is: SBO:0000252

metaR GGLUCT
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
reactant: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
name: gamma-glutamylcyclotransferase
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3d64728d_ee25_4094_bec8_1e74e04a6da3
boundary condition: true
type: Species
is: SBO:0000252
is: P54819
name: AK2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:204
constant: false

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000134
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#

metaR ARTCOAL2
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
name: R group coenzyme a ligase
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
product: MODEL1310110032#

metaM gthrd e
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00125
boundary condition: false
name: glutathionate(1-)
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925

metaR r2096
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ATPtx
type: Reaction
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110032#
name: ATP transporter, peroxisomal
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR NACHEXA10ly
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110032#
reversible: false

metaR O2Stm
is: SBO:0000185
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

metaR CITtbm
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
fast: false
modifier: MODEL1310110032#
name: citrate transport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reversible: true

metaR r2004
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0386
fast: false
reversible: false
reactant: MODEL1310110032#
type: Reaction
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7b36c35f_a6b8_45b8_a24e_1e645a7e45df
constant: false
is encoded by: hsa:6240
has part: P23921
has part: P31350
is encoded by: hsa:6241
is: SBO:0000297
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: RRM1:RRM2
has only substance units: false

metaM co2 r
type: Species
has only substance units: false
is: C00011
boundary condition: false
constant: false
is: HMDB01967
name: CO2
is: CHEBI:16526
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: SBO:0000247

metaM malcoa e
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
has only substance units: false
is: HMDB01175
name: malonyl-CoA(4-)
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57384
initial amount: NaN
type: Species

metaR PCHOLPr hs
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
reversible: false
name: choline phosphatase

metaR DNDPt2m
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dATP transport via ATP antiport
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_c5609e6f_75ce_4770_ad5f_014b1055952e
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P00338
type: Species
name: LDHA
constant: false
boundary condition: true
is encoded by: hsa:3939

metaR r2095
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_5ef608ea_61ef_44ed_99f1_d413f9ba1f33
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: SLC27A1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:376497
boundary condition: true

metaM ksi l
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
is: C00445
constant: false
is: CHEBI:57455
type: Species
is: HMDB01354
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR CHOLtn
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
name: Choline transport, nuclear through pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction

metaR r2005
fast: false
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0b0df958_7b30_4604_a614_270071959acb
is encoded by: hsa:6580
type: Species
constant: false
is: O15245
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC22A1
boundary condition: true
initial concentration: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR NDPK6m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000254
modifier: MODEL1310110032#
fast: false
reversible: true
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6c4e704a_3554_4072_9125_5e75baca4519
constant: false
is: P54868
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3158
initial amount: NaN
type: Species
initial concentration: NaN
name: HMGCS2

metaR r0385
is described by: ECO:0000000
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6c714c5c_2820_4ea7_9b45_eee1831cb5dd
is encoded by: hsa:AI440329
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: _AI440329_1_r
is: SBO:0000252
has only substance units: false

metaM nad r
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00902
name: NAD(1-)
is: CHEBI:57540
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

metaM urate e
boundary condition: false
is: CHEBI:17775
is: C00366
constant: false
name: Urate
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00289
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
initial concentration: 1.0

metaR LPCOXp
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110032#
name: L-pipecolate oxidase, peroxisomal
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.3.1

http://identifiers.org/biomodels.db/MODEL1310110032#_36977742_e3ce_497d_8780_ac35fd9d42da
constant: false
initial concentration: NaN
has only substance units: false
name: SOD3
is: SBO:0000252
type: Species
boundary condition: true
is: P08294
initial amount: NaN
is encoded by: hsa:6649

metaR r2094
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false

metaR DURIPP
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is described by: ECO:0000269
name: deoxyuridine phosphorylase
fast: false
kinetic law: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction

metaM b2coa m
initial amount: NaN
name: crotonoyl-CoA(4-)
type: Species
boundary condition: false
is: CHEBI:57332
is: HMDB02009
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r0308
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
type: Reaction
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
kinetic law: MODEL1310110032#
reversible: false
product: MODEL1310110032#
is described by: ECO:0000000

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM gthrd c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
initial amount: NaN
is: SBO:0000247
name: Reduced glutathione
boundary condition: false
is: C00051
type: Species
is: HMDB00125
is: CHEBI:57925

metaR FUMSO4tm
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true
name: Fumarate:sulfate antiport, mitochondrial
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_6117012b_7754_4e56_a07a_c816eb8f503f
type: Species
name: ADSL
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:158
has only substance units: false
is: P30566
constant: false
initial amount: NaN

metaR DHCR72r
kinetic law: MODEL1310110032#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.21
fast: false
reactant: MODEL1310110032#
name: 7-dehydrocholesterol reductase
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110032#

metaR NDPK6n
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
reversible: true
fast: false

metaR r0170
type: Reaction
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_a36aae9c_1ede_461d_aa68_3c4526f3c34f
is: SBO:0000252
is encoded by: hsa:8395
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: PIP5K1B
is: O14986
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_44ced092_ba3c_4de7_a354_7c8d78988efe
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3948
name: LDHC
constant: false

metaR r0384
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
reactant: MODEL1310110032#
type: Reaction
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#

metaM btamp m
type: Species
is: HMDB04220
is: SBO:0000247
has only substance units: false
is: CHEBI:3110
initial amount: NaN
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0
boundary condition: false
constant: false

metaM dgtp n
initial concentration: 1.0
is: C00286
is: CHEBI:16497
is: HMDB01440
name: dGTP
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110032#_3ccc673a_43eb_4a31_a773_1fdae73c22f6
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23417
has only substance units: false
is: SBO:0000252
is: O95822
type: Species
initial amount: NaN
name: MLYCD

metaR SGALSIDEtg
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: sgalside hs intracellular transport
reactant: MODEL1310110032#
type: Reaction
fast: false
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_d15e43ba_4c29_4fc0_b4e6_d8c2071602d2
is: SBO:0000252
is encoded by: hsa:51079
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: NDUFA13
is: Q9P0J0

http://identifiers.org/biomodels.db/MODEL1310110032#_63053c1a_9983_46a4_b7b4_b5400cb1f0aa
boundary condition: true
is encoded by: hsa:4715
type: Species
has only substance units: false
name: NDUFB9
initial amount: NaN
is: Q9Y6M9
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR S2TASE3ly
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: iduronate-2-sulfatase, lysosomal

metaM dtdp m
boundary condition: false
initial concentration: 1.0
is: C00363
has only substance units: false
is: HMDB01274
constant: false
initial amount: NaN
name: dTDP
is: SBO:0000247
type: Species
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaM urate c
name: Urate
type: Species
is: CHEBI:17775
is: SBO:0000247
has only substance units: false
is: C00366
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
boundary condition: false
is: HMDB00289

metaR r0383
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
name: pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000

metaR FAOXC16DCr
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_81e547fb_75cc_4950_9ed1_eb648e0fe76c
constant: false
has only substance units: false
name: TUSC3
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7991
initial concentration: NaN

metaR NAGA2ly
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
reversible: false
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.49

metaR r2007
fast: false
product: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1ab66cd2_2618_4202_a5fc_85d440b2d86e
constant: false
type: Species
initial concentration: NaN
name: MYO5B
is: SBO:0000252
is encoded by: hsa:4645
has only substance units: false
is: Q9H6Y6
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_d8aad254_ea7d_421b_9167_ff9b5fe2d223
name: BAAT
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:570
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q14032

metaR UAG4E
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: UDP-N-acetylglucosamine 4-epimerase
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_154ef639_c95c_4c0e_bc9a_566b806f15d4
is encoded by: hsa:23236
constant: false
is: SBO:0000252
boundary condition: true
name: PLCB1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM cdpdag hs m
initial amount: NaN
is: CHEBI:58332
boundary condition: false
constant: false
name: CDP-diacylglycerol(2-)
type: Species
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial concentration: 1.0
is: SBO:0000247

metaM Tn antigen g
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C04383
constant: false
is: SBO:0000247
name: Tn antigen
has only substance units: false
type: Species

metaM dtdp n
boundary condition: false
initial concentration: 1.0
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR LYSOXp
is: SBO:0000176
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000

metaR HMGCOASim
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
type: Reaction
reactant: MODEL1310110032#
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_3cc7a919_ea08_4711_9240_901c2d9d5ecf
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:93034
initial amount: NaN
has only substance units: false
is: Q96P26
boundary condition: true
name: NT5C1B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_3f4d816a_7059_4481_a6f2_87402d129262
type: Species
is: P54868
is encoded by: hsa:3158
constant: false
name: HMGCS2
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR LINOFATPtc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR EX 5htrp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-Hydroxy-L-tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2787c680_c219_4b05_8bed_d6e1144c3b1d
is: E7EPT3
boundary condition: true
is encoded by: hsa:501
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: ALDH7A1
initial concentration: NaN
initial amount: NaN

metaR r1163
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
fast: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#

metaR DTTPtn
fast: false
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110032#

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
has only substance units: false
is: CHEBI:57795
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8f4dd6c1_8195_4998_8150_d4f10a016774
has only substance units: false
initial amount: NaN
is: P35557
initial concentration: NaN
name: GCK
constant: false
is: SBO:0000252
is encoded by: hsa:2645
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_9fac6979_26bd_4182_8b0c_7bf89e09d3d6
has only substance units: false
is encoded by: hsa:171425
type: Species
initial concentration: NaN
constant: false
name: CLYBL
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2099
product: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110032#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true

metaM C02528 c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
is: HMDB00518
is: CHEBI:36234
name: chenodeoxycholate
type: Species

metaR APOCF
fast: false
name: Apocarboxylase formation
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaR ACOAD9m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110032#
product: MODEL1310110032#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ad026aae_b157_4890_b4b8_a0b42dcb61b6
is: Q9UGH3
name: SLC23A2
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9962
initial concentration: NaN
type: Species

metaR OMPDC
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.10
kinetic law: MODEL1310110032#
name: orotidine-5'-phosphate decarboxylase
type: Reaction
is described by: ECO:0000269

metaR ASPDxt
kinetic law: MODEL1310110032#
reversible: true
fast: false
name: D-aspartate transport, peroxisomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
type: Reaction

metaM xu5p D c
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57737
constant: false
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_070e2265_784b_4a4b_bd7c_6d9c4dae96a0
is: SBO:0000252
name: MYO5B
constant: false
initial amount: NaN
is: Q9H6Y6
boundary condition: true
is encoded by: hsa:4645
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_36333af6_b701_4872_a037_6f3615cba221
initial amount: NaN
is encoded by: hsa:AI924226
type: Species
name: _AI924226_1_m
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM 25hvitd3 m
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB03550
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17933
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 EHMN_ABBREVIATION: C01561
name: calcidiol

http://identifiers.org/biomodels.db/MODEL1310110032#_377c674b_56e6_4beb_a8c2_e8de408d437f
name: AK4
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:205

metaM ahcys m
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
initial amount: NaN
is: C00021
is: HMDB00939
constant: false
is: SBO:0000247
is: CHEBI:16680
type: Species
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false

metaR r1164
is: SBO:0000176
name: EC:2.3.1.26
fast: false
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_15016a46_3f59_45d5_aedb_0cb05e590f18
is: SBO:0000252
constant: false
boundary condition: true
is: B4DKS0
has only substance units: false
initial amount: NaN
name: SLC16A1
is encoded by: hsa:6566
initial concentration: NaN
type: Species

metaR r1538
fast: false
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
kinetic law: MODEL1310110032#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
product: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaM succ x
is: C00042
is: HMDB00254
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:30031
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
name: Succinate
boundary condition: false
type: Species

metaR 5ADTSTSTERONESte
type: Reaction
is: SBO:0000185
name: sulfonated testosterone transport
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
product: MODEL1310110032#
is described by: ECO:0000000

metaR r2098
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM abt e
has only substance units: false
boundary condition: false
name: L-arabinitol
is: HMDB01851
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18403
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532

metaM Nacasp m
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: HMDB00812
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16953
name: N-acetyl-L-aspartate(2-)

http://identifiers.org/biomodels.db/MODEL1310110032#_ab17fe91_ffbc_41a3_a7bc_005c9fdb87cf
is: SBO:0000252
type: Species
is encoded by: hsa:4710
is: O95168
name: NDUFB4
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR RE1709C
reactant: MODEL1310110032#
name: RE1709
product: MODEL1310110032#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
reversible: true

metaM galgbside hs g
name: galactosylgloboside
initial concentration: 1.0
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:18259
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8d0f5701_f29a_42e6_b9a5_aed85ef5e7d4
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:768
boundary condition: true
is: Q16790
initial amount: NaN
constant: false
name: CA9
initial concentration: NaN

metaR r0410
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110032#
type: Reaction
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110032#_2525e80e_06c1_4317_961f_638f47c4ba42
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:441024
type: Species
has only substance units: false
is: Q9H903
name: MTHFD2L
is: SBO:0000252
initial concentration: NaN

metaR FAOXC18480m
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110032#
reversible: false
product: MODEL1310110032#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110032#

metaR PRDX
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
product: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.11.1.7
reversible: false
type: Reaction
name: Peroxidase (multiple substrates)
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false
modifier: MODEL1310110032#

metaR r2526
product: MODEL1310110032#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f813fe69_e4be_4baf_8bd7_e597532af7bb
constant: false
has only substance units: false
initial concentration: NaN
name: ALOX5
initial amount: NaN
is: SBO:0000252
is: P09917
type: Species
boundary condition: true
is encoded by: hsa:240

metaM ksi deg32 l
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00143
type: Species
boundary condition: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
name: keratan sulfate I, degradation product 32
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR P4507A1r
is version of: http://identifiers.org/ec-code/1.14.13.17
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
name: cytochrome P450, family 7, subfamily A, polypeptide 1
reversible: false
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_13ea1fa3_f4cc_4cea_844f_a59655355d44
is encoded by: hsa:39
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: Q9BWD1
boundary condition: true
name: ACAT2
is: SBO:0000252
has only substance units: false

metaR RE1531M
product: MODEL1310110032#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110032#
name: RE1531
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_51aea007_756d_4da5_b7a9_6563dfd4f87f
is encoded by: hsa:2592
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: B2RAT6
initial amount: NaN
name: GALT
boundary condition: true

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8747a31a_e1a2_4b57_899a_6ca71de1a48f
is encoded by: hsa:491
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: ATP2B2
constant: false
is: Q4J699
initial concentration: NaN
has only substance units: false

metaR FAOXC140
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110032#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110032#
fast: false
reversible: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM HC01408 m
constant: false
is: CHEBI:27648
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
has only substance units: false
initial concentration: 1.0
type: Species

metaM 13dampp c
boundary condition: false
name: trimethylenediaminium
is: SBO:0000247
is: CHEBI:57484
constant: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
initial concentration: 1.0
is: HMDB00002
type: Species
has only substance units: false
initial amount: NaN

metaM leuktrE4 c
type: Species
initial concentration: 1.0
boundary condition: false
name: leukotriene E4(1-)
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
is: CHEBI:57462

metaM HC02217 c
initial amount: NaN
has only substance units: false
name: prostaglandin-g2
is: CHEBI:27647
type: Species
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_2b8087d8_e176_4792_8425_f7c17ba0c5e9
is encoded by: hsa:3992
initial amount: NaN
has only substance units: false
name: FADS1
is: SBO:0000252
is: O60427
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaM 44mzym r
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01286
is: SBO:0000247
name: 14-demethyllanosterol
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: CHEBI:18364

metaR RE0958E
product: MODEL1310110032#
fast: false
name: RE0958
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:

metaR r2389
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110032#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110032#
reversible: false
is: SBO:0000185

metaM f1a g
is: CHEBI:17151
has only substance units: false
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
name: F1alpha
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR CHOLtu
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
name: Choline uniport

metaR r2525
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaR r0655
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
reversible: true

metaM ksi e
initial amount: NaN
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
is: HMDB00211
boundary condition: false
constant: false
type: Species
name: keratan sulfate I
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_4858fcc3_387b_4c46_977b_3caa7e96e3fa
is: SBO:0000252
constant: false
name: GGT7
is: A0PJJ9
has only substance units: false
is encoded by: hsa:2686
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM gthrd m
name: glutathionate(1-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57925
is: SBO:0000247
is: HMDB00125
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_313b8aa2_ee8f_468c_b2dd_715823cae1aa
initial concentration: NaN
name: HSD17B10
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q99714
is encoded by: hsa:3028

metaR RE1709N
name: RE1709
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

metaR FAOXC80
name: Beta oxidation of med/long chain fatty acid
fast: false
modifier: MODEL1310110032#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_0a9e234e_f2f7_4821_99de_6abffa3200ae
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6508
name: SLC4A3
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_cc2a9f41_82a1_4996_82e9_29460850f0b4
is encoded by: hsa:4731
constant: false
name: NDUFV3
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR ACGALK
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000000
name: N-acetylgalactosamine kinase
reversible: false
product: MODEL1310110032#

metaM abt c
constant: false
initial concentration: 1.0
name: L-arabinitol
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247
is: HMDB01851
boundary condition: false
type: Species
is: CHEBI:18403

metaM co2 m
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01967
is: CHEBI:16526
is: C00011
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
boundary condition: false
name: CO2

metaM cmp m
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
has only substance units: false
is: CHEBI:60377
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00095
name: CMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110032#_7d4fa600_3493_4d41_9b99_3c42cf0ab9fd
name: PECR
boundary condition: true
constant: false
is encoded by: hsa:55825
is: SBO:0000252
is: Q9BY49
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM aacoa m
name: acetoacetyl-CoA(4-)
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
initial concentration: 1.0
is: HMDB01484
initial amount: NaN

metaM orot c
constant: false
is: C00295
boundary condition: false
initial amount: NaN
has only substance units: false
name: Orotate
is: HMDB00226
is: CHEBI:30839
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_e2d394e2_7aa2_43f4_bac7_0059cf16dabd
initial amount: NaN
name: PRODH2
has only substance units: false
is: Q9UF12
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:58510

metaR r0652
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110032#
type: Reaction
reversible: true
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR ACOAD1fm
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
is: SBO:0000247
is: CHEBI:58672
has only substance units: false
is: HMDB00510
initial amount: NaN
constant: false
initial concentration: 1.0
name: L-2-aminoadipate(1-)
type: Species

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: leukotriene E4(1-)
is: HMDB02200
type: Species
is: CHEBI:57462
constant: false
is: SBO:0000247

metaM xol7aone m
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
constant: false
is: HMDB01993
type: Species
boundary condition: false
initial amount: NaN

metaM HC01407 m
boundary condition: false
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28276
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
type: Species
is: SBO:0000247

metaR RE2269E
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.21.39
name: RE2269

http://identifiers.org/biomodels.db/MODEL1310110032#_d4d9dbaa_c9e3_4e0b_b471_62edc11a45b1
is: Q8IWW8
has only substance units: false
boundary condition: true
is encoded by: hsa:137872
name: ADHFE1
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaM 1pyr5c c
initial concentration: 1.0
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
is: HMDB01301
constant: false
type: Species
is: CHEBI:15893
initial amount: NaN
is: C03912
boundary condition: false

metaM g6p c
is: CHEBI:61548
initial amount: NaN
type: Species
is: HMDB01401
is: SBO:0000247
boundary condition: false
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
constant: false
initial concentration: 1.0
has only substance units: false

metaR DGULND
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
name: dehydro-L-gulonate decarboxylase
is: SBO:0000176
type: Reaction
product: MODEL1310110032#

metaR B3GNT51g
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000304
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
modifier: MODEL1310110032#

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
is: CHEBI:28002
has only substance units: false
constant: false
initial amount: NaN
name: cis,cis-3,6-Dodecadienoyl-CoA
is: HMDB03952
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM pa hs c
is: CHEBI:57739
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: phosphatidate(2-)
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

metaM ahcys r
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00939
is: SBO:0000247
is: CHEBI:16680
name: S-adenosyl-L-homocysteine
initial amount: NaN
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaR r0653
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false
fast: false
type: Reaction

metaR PPItm
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reversible: true
fast: false
name: diphopshate transporter, mitochondrial
product: MODEL1310110032#

metaM occoa c
is: CHEBI:57386
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: HMDB01070
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
constant: false
initial amount: NaN

metaR SGALSIDEtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
name: sgalside hs intracellular transport
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_edc1f63f_f01a_428e_8368_74a4f658f75d
type: Species
boundary condition: true
is: Q05940
initial concentration: NaN
is encoded by: hsa:6571
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: SLC18A2

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR MI1PP
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110032#
name: myo-inositol 1-phosphatase
is: SBO:0000176

metaR MEOHt2
name: Methanol diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false

metaR RE3326M
fast: false
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
name: RE3326
kinetic law: MODEL1310110032#

metaR CDIPTr
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: phosphatidylinositol synthase (Homo sapiens)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.11
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

metaM lpam m
is: CHEBI:17460
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
is: HMDB00962
is: SBO:0000247
name: lipoamide
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_f62f4e85_d414_4ff6_acab_e34d41434f7e
name: ATIC
has only substance units: false
type: Species
initial amount: NaN
is: P31939
is encoded by: hsa:471
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR BTNPLm
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reversible: true
product: MODEL1310110032#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reactant: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction

metaR LEUKTRD4t
is described by: ECO:0000269
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110032#
type: Reaction
name: leukotriene D4 transport
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_cdbd0645_0949_4e1c_b0f0_dba75a89d19d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:125206
boundary condition: true
constant: false
name: SLC5A10
has only substance units: false
is: A0PJK1
initial amount: NaN
type: Species

metaM ksi deg30 l
type: Species
name: keratan sulfate I, degradation product 30
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
constant: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110032#_84d11c1b_ffe7_477f_83e8_0eb71d775adc
is encoded by: hsa:6818
boundary condition: true
is: SBO:0000252
is: Q1ET61
constant: false
name: SULT1A3
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM CE1926 e
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
type: Species
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15748
is: SBO:0000247

metaM cs a deg4 l
is: CHEBI:16953
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
notes: FORMULA: C31H49NO29S CHARGE: -2
is: HMDB00812
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC161802m
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
product: MODEL1310110032#
type: Reaction

metaR RPEc
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
fast: false
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000134

metaR 3SALAASPm
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
name: cysteinesulfinate-aspartate mitochondrial shuttle
type: Reaction
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
reactant: MODEL1310110032#

metaR r2521
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
name: Utilized transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR CYSGLUexR
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110032#
fast: false
name: L-cysteine/L-glutamine reversible exchanger
type: Reaction

metaM dcacoa x
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
type: Species
initial amount: NaN
is: HMDB06404
has only substance units: false
constant: false

metaM malthp e
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
is: C01936
is: SBO:0000247
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
type: Species
has only substance units: false
boundary condition: false
name: maltoheptaose
initial amount: NaN

metaR ATPH2e
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
name: ATP diphosphohydrolase
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_0532f236_250e_4cf8_88cb_fababfb579fe
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:51095
name: TRNT1
is: Q96Q11

metaR RE3421R
name: RE3421
product: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_3234ec3c_733a_49e9_9515_9c7ea390eeb8
initial amount: NaN
boundary condition: true
has only substance units: false
name: ACSL3
is encoded by: hsa:2181
is: SBO:0000252
initial concentration: NaN
type: Species
is: B3KMA6
constant: false

metaR LEUt5m
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
name: leucine mitochondrial transport
reactant: MODEL1310110032#

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM prostgi2 e
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01335
has only substance units: false
name: prostaglandin I2(1-)
initial concentration: 1.0
type: Species
constant: false

metaR CHOLtr
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000185
name: choline intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110032#_300f0791_fb8f_4c3b_92de_489d944d364e
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: AK1
initial amount: NaN
is: P00568
is: SBO:0000252
is encoded by: hsa:203
constant: false

metaR r0656
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110032#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
product: MODEL1310110032#
reversible: false
fast: false
type: Reaction

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3186b326_cb51_4f15_add5_30c6f8afe1f3
constant: false
is: Q96DU7
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:80271
initial concentration: NaN
name: ITPKC
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_95597011_b949_48bc_9e52_65774e8eab1e
is encoded by: hsa:123041
type: Species
initial concentration: NaN
name: SLC24A4
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110032#
name: Glutamine transport (Na, H coupled)
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_d5b119f7_3398_4b2d_ab30_c60100fbbe61
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: B1AM93
is encoded by: hsa:4702
name: NDUFA8
constant: false
initial amount: NaN
has only substance units: false

metaR G5SADrm
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD

metaR PGK
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110032#
name: phosphoglycerate kinase
is version of: http://identifiers.org/ec-code/2.7.2.3
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134

metaR r0281
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#

metaM ksi deg3 l
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01356
constant: false
boundary condition: false
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
name: keratan sulfate I, degradation product 3
is: CHEBI:57312
initial amount: NaN
initial concentration: 1.0

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR DHAAt1r
product: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
fast: false
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reactant: MODEL1310110032#
is: SBO:0000185
name: dehydroascorbate transport (uniport)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_a4931d4d_9e3a_4ed2_aabe_51d798650263
type: Species
name: ALPL
boundary condition: true
constant: false
is: B7Z4Y6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:249
initial concentration: NaN
has only substance units: false

metaM cmp n
is: HMDB00095
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
name: CMP(2-)
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:60377

metaR SERHL
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: L-Serine hydro-lyase
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110032#
product: MODEL1310110032#

metaM pglyc hs c
initial amount: NaN
is: HMDB02704
constant: false
is: CHEBI:21338
is: SBO:0000247
notes: FORMULA: CHARGE: 0
has only substance units: false
initial concentration: 1.0
type: Species
name: pglyc_hs[c]
boundary condition: false

metaM nad m
is: C00003
initial amount: NaN
is: HMDB00902
is: CHEBI:57540
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3305

metaR ARABR
modifier: MODEL1310110032#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: arabinose reductase
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:

metaR SBTR
product: MODEL1310110032#
name: D-sorbitol reductase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:

metaR r2520
is: SBO:0000185
reactant: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_df7f9b4f_6315_457d_8ae0_9e1c907f623c
is: P42765
initial concentration: NaN
name: ACAA2
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10449
constant: false
has only substance units: false
type: Species

metaR N2M2NMASNtly
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
reversible: false
type: Reaction
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_aa8b173e_4399_49f5_ad9f_218edf8502e1
initial amount: NaN
is encoded by: hsa:AA532636
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AA532636_1_m
has only substance units: false
boundary condition: true

metaR CYTK2n
type: Reaction
fast: false
product: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110032#_49edb7f3_1d38_422d_8265_d8cbdee6a359
initial amount: NaN
is encoded by: hsa:2222
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: FDFT1
is: P37268

metaM ksi deg41 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 41
notes: FORMULA: C34H58N2O26 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00143
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR r0494
fast: false
reactant: MODEL1310110032#
type: Reaction
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR r0280
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction

metaM 3sala m
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
has only substance units: false
name: 3-sulfino-L-alanine (1-)
is: SBO:0000247
is: CHEBI:61085
initial concentration: 1.0
type: Species
is: C00606

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_033580d2_724c_4e96_bed3_c10daba42663
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O43677
type: Species
name: NDUFC1
is encoded by: hsa:4717

metaM prostgi2 c
is: CHEBI:57403
constant: false
boundary condition: false
has only substance units: false
name: prostaglandin I2(1-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01335
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaR CHAT
name: Choline O-acetyltransferase
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_684d7c43_98c3_4f6d_87ab_484eed2a6736
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:271
name: AMPD2
is: B2RB47
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b530c7e2_32bb_4c78_86ef_fa89075f97be
initial concentration: NaN
name: _AL525798_1_c
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AL525798
boundary condition: true

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR GLYCTO1p
reversible: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.3.15
reactant: MODEL1310110032#
is described by: ECO:0000269
name: Glycolate oxidase, peroxisome
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_a902807e_9f49_4f69_80f6_77510fb04ca4
is encoded by: hsa:3990
name: LIPC
is: A6H8L5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaR SERPT
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110032#
name: serine C-palmitoyltransferase
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.50

metaR NDPK6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000269
fast: false
name: Nucleoside-diphosphate kinase (ATP:dUDP)
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction
product: MODEL1310110032#

metaR RE3242R
is: SBO:0000176
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3242
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110032#

metaR LPS3e
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
name: lipase, extracellular
is version of: http://identifiers.org/ec-code/3.1.1.3

metaM dcholcoa x
is: CHEBI:28701
is: SBO:0000247
type: Species
name: chenodeoxycholoyl coenzyme a
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110032#_80479496_4fb5_4a87_8425_d5acbfa2ef5f
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4729
boundary condition: true
initial amount: NaN
constant: false
name: NDUFV2
is: P19404

metaM cmp c
constant: false
is: CHEBI:60377
is: C00055
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
type: Species
initial concentration: 1.0
name: CMP
initial amount: NaN

metaM co2 c
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: C00011
is: HMDB01967
is: CHEBI:3313
name: CO2
notes: FORMULA: CO2 CHARGE: 0
initial amount: NaN

metaR r1377
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_41182351_57c8_49df_af14_233191923b0f
constant: false
initial amount: NaN
name: PLCB3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5331
is: G5E960
type: Species
has only substance units: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR DASCBR
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.4.1
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
name: dehydroascorbate reductase
reversible: false
type: Reaction

metaR H2O2tp
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
fast: false
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110032#_47321c97_39d9_4ee9_a7cf_a94a95c7371e
initial concentration: NaN
initial amount: NaN
name: HK2
has only substance units: false
is: P52789
is: SBO:0000252
is encoded by: hsa:3099
constant: false
boundary condition: true
type: Species

metaR r2308
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_706cbd0b_79ad_486c_ab9c_d58ca0134de3
is encoded by: hsa:89869
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PLCZ1
constant: false
has only substance units: false
is: Q86YW0
type: Species

metaR FADH2tru
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: false
product: MODEL1310110032#
type: Reaction

metaM succ c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
constant: false
is: CHEBI:30031
is: C00042
initial amount: NaN
has only substance units: false
is: HMDB00254
type: Species
initial concentration: 1.0

metaR DESAT22 1p
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reactant: MODEL1310110032#
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000

metaR NDPK5
is described by: ECO:0000269
modifier: MODEL1310110032#
is: SBO:0000176
type: Reaction
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8f6f0244_32a1_40f9_aa3f_88001eacbc34
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11254
boundary condition: true
is: Q9UN76
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: SLC6A14

http://identifiers.org/biomodels.db/MODEL1310110032#_e4a07f86_65b0_44c4_a748_5ddfe3b2c717
initial concentration: NaN
name: MDH2
boundary condition: true
type: Species
is: P40926
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4191

metaM leuleu c
name: Leucylleucine
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H24N2O3 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/94244

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM 3snpyr m
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:1665
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
name: 3-Sulfinopyruvate
initial amount: NaN
type: Species
is: HMDB02332
is: SBO:0000247
initial concentration: 1.0

metaR biomass reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
reversible: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#

metaM paf hs e
is: CHEBI:36707
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3f5644ef_5b5c_4997_a01c_6add58444bbe
is encoded by: hsa:1743
is: SBO:0000252
name: DLST
type: Species
initial amount: NaN
has only substance units: false
is: P36957
initial concentration: NaN
boundary condition: true
constant: false

metaM hom L e
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15699
type: Species
constant: false
name: L-homoserine
boundary condition: false
is: HMDB00719

metaR r1378
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
fast: false

metaR PE HStm
type: Reaction
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000

metaR RIBt
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: ribose transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110032#

metaR OAGD3te
name: oagd3 hs transport
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
reversible: true

metaM triodthy e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB00265

metaR FAOXC16080m
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9a01dff2_c8bc_435d_8f44_3d6354e0274e
has only substance units: false
is encoded by: hsa:3037
type: Species
is: SBO:0000252
is: Q92819
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: HAS2

metaR NDPK4
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_1113428b_858e_4a84_b12e_eeac71ab92a7
has only substance units: false
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaR AMETr
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reversible: true
name: S-Adenosyl-L-methionine intracellular diffusion
product: MODEL1310110032#
fast: false

metaR RE3050R
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: RE3050
type: Reaction
reversible: true

metaM hdd2coa x
initial amount: NaN
is: CHEBI:61526
is: HMDB03945
constant: false
type: Species
name: (E)-hexadec-2-enoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_cfe19e92_5a12_4a8a_9f12_883719df0c21
type: Species
constant: false
name: SLC16A7
initial concentration: NaN
is encoded by: hsa:9194
initial amount: NaN
is: Q8NEM3
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM cmp e
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: SBO:0000247
boundary condition: false
is: HMDB00095
type: Species
has only substance units: false
initial concentration: 1.0
name: CMP(2-)
initial amount: NaN
constant: false

metaM co2 e
name: CO2
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
type: Species
is: C00011
is: CHEBI:16526
has only substance units: false
initial concentration: 1.0
is: HMDB01967
initial amount: NaN
constant: false

metaM gdp m
boundary condition: false
initial concentration: 1.0
type: Species
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
is: HMDB01201
is: SBO:0000247
is: C00035
constant: false
initial amount: NaN
is: CHEBI:58189

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM duri n
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00012
constant: false
name: 2'-deoxyuridine
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
is: SBO:0000247

metaM udpgal c
is: HMDB00302
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:58439
initial amount: NaN
name: UDP-D-galactose(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9e6142b1_3cd6_4d59_a9f4_c565e339f967
boundary condition: true
has only substance units: false
constant: false
name: _AI694761_1_c
is: SBO:0000252
is encoded by: hsa:AI694761
initial concentration: NaN
type: Species
initial amount: NaN

metaM HC00342 m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: cis-aconitate(3-)
initial amount: NaN
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false

metaR r1259
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_20e9f1de_8819_45be_8b65_c4d67d48a9b6
name: _AI972237_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:AI972237
boundary condition: true
type: Species

metaR r0885
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
product: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#

metaR RE1796M
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
kinetic law: MODEL1310110032#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true

metaR NDPK3
modifier: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:CDP)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM pa hs m
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57739
type: Species
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR B3GALT3g
name: Beta-1,3-galactosyltransferase 3
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.79
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaR 34DHPHEt
name: 3,4-Dihydroxy-L-phenylalanine transport
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM h2o r
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: HMDB02111
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: C00001
name: H2O
initial concentration: 1.0
is: CHEBI:15377

metaR r0287
product: MODEL1310110032#
is described by: ECO:0000000
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reactant: MODEL1310110032#
type: Reaction
reversible: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176

metaM gchola c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
type: Species
is: HMDB00138
constant: false
is: CHEBI:58235
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: glycocholate

http://identifiers.org/biomodels.db/MODEL1310110032#_42facac2_948e_48ba_bc64_b87c3a1b3406
initial amount: NaN
name: SLC25A10
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1468
is: Q9UBX3
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_a0639fdf_1d02_4e5e_8999_d59d3901bfc6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29988
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9NY64
has only substance units: false
name: SLC2A8

metaM lnlccoa c
name: linoleic coenzyme A
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01064
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164

metaR OAGD3tg
name: oagd3 hs intracellular transport
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
reversible: true

metaR r1898
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110032#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110032#
reversible: false

metaR NDPK2
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f439bcd5_90e3_4cd5_8ca2_c9b68e5895c5
name: SLC25A11
type: Species
is: F5GY65
is encoded by: hsa:8402
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM coa g
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57287
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01423
initial amount: NaN
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
is: CHEBI:18258
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaM cmp g
constant: false
is: CHEBI:60377
boundary condition: false
has only substance units: false
is: HMDB00095
name: CMP(2-)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

http://identifiers.org/biomodels.db/MODEL1310110032#_41b913cb_ee34_478a_a323_bcd46a59bc4a
boundary condition: true
is: Q9NYQ3
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: HAO2
has only substance units: false
type: Species
is encoded by: hsa:51179

metaM r1p c
is: SBO:0000247
initial amount: NaN
name: alpha-D-Ribose 1-phosphate
is: C00442
is: HMDB01489
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57720
constant: false
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442

metaR FALDH
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: true
fast: false
name: formaldehyde dehydrogenase
product: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110032#

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM dpcoa l
is: CHEBI:57328
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
initial amount: NaN
name: 3'-dephospho-CoA(2-)

metaR r1052
fast: false
name: Vesicular transport
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0ecdc55e_fa44_424d_82d4_3d5e854e2be3
initial amount: NaN
is encoded by: hsa:AI090874
constant: false
name: _AI090874_1_c
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GAL3ST12
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
fast: false
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: Galactosylceramide sulfotransferase
product: MODEL1310110032#

metaR MMCDm
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.1.1.9
is: SBO:0000176
reactant: MODEL1310110032#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000212
fast: false
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
product: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6a6c28e9_81b0_418f_8367_9e14faff4620
constant: false
initial concentration: NaN
has only substance units: false
name: IDUA
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3425
type: Species
boundary condition: true
is: P35475

metaR PPItr
type: Reaction
kinetic law: MODEL1310110032#
name: Diphosphate transporter, endoplasmic reticulum
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110032#
fast: false
is: SBO:0000185

metaR r1679
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaM coa l
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: CHEBI:57287
initial concentration: 1.0
name: coenzyme A(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_70498fa4_1739_416b_991c_ee7c3dc52e6a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:60490
has only substance units: false
name: PPCDC
constant: false
is: Q96CD2
type: Species
initial amount: NaN

metaM gdp n
has only substance units: false
is: CHEBI:58189
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01201
boundary condition: false
initial concentration: 1.0
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species

metaR BDHm
kinetic law: MODEL1310110032#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true

metaM asp L m
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: L-aspartate(1-)
is: CHEBI:29991
is: HMDB00191
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

http://identifiers.org/biomodels.db/MODEL1310110032#_2c6f23cc_eebf_4eb6_95ed_09d161d34d74
initial amount: NaN
is encoded by: hsa:2876
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: GPX1

metaR r0660
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_7b90c935_c875_4f95_8b32_9a62332e497e
initial concentration: NaN
boundary condition: true
is encoded by: hsa:122622
type: Species
constant: false
is: Q8N142
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ADSSL1

metaM sucsal m
name: Succinic semialdehyde
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57706
is: HMDB01259
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247

metaR NDPK9
modifier: MODEL1310110032#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110032#

metaM gchola e
is: SBO:0000247
is: HMDB00138
name: glycocholate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0

metaR ARACHCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: transport into the mitochondria (carnitine)
type: Reaction

metaM dpcoa m
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: 3'-dephospho-CoA(2-)
is: HMDB01373

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00472
constant: false
type: Species
is: CHEBI:17780
initial amount: NaN
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643

http://identifiers.org/biomodels.db/MODEL1310110032#_00e310bb_c67e_41b0_94b1_91f7ea89d227
has only substance units: false
initial concentration: NaN
is: P21953
boundary condition: true
name: BCKDHB
type: Species
constant: false
is encoded by: hsa:594
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b49e7831_72b5_4475_aa94_874b3987d99d
has only substance units: false
name: _H53099_1_m
is encoded by: hsa:H53099
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM 4abutn m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01080
name: 4-ammoniobutanal
has only substance units: false
is: CHEBI:58264
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false

metaR DASPO1p
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.4.3.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
modifier: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
name: D-aspartate oxidase, peroxisomal

metaM xol7aone r
initial amount: NaN
is: CHEBI:17899
is: HMDB01993
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0
boundary condition: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
type: Species

metaM h2o x
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: C00001
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB02111
is: CHEBI:15377

metaR GAL3ST11
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is described by: ECO:0000000
name: Galactosylceramide sulfotransferase
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
type: Reaction
reactant: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5c599631_3815_4826_bba1_ce92e56df958
initial amount: NaN
boundary condition: true
name: LDHA:LDHB
is encoded by: hsa:3939
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000297
has part: P07195
type: Species
has part: P00338
is encoded by: hsa:3945

http://identifiers.org/biomodels.db/MODEL1310110032#_0c5fccce_baae_4926_9851_4cdcebf58b95
boundary condition: true
is: P56556
is encoded by: hsa:4700
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFA6
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_9a1ad151_ffb1_46a5_a7c0_6c6daf99d9bc
name: _D29675_1_e
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:D29675
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d0013e33_a51d_4adf_8f09_1faf55ae41dd
constant: false
is: Q8N4Q0
initial concentration: NaN
is encoded by: hsa:284273
name: ZADH2
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR r0999
product: MODEL1310110032#
is: SBO:0000185
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110032#

metaR OXAHCOtex
is: SBO:0000185
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
name: oxalate transport via bicarbonate countertransport
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_11909a61_1a3a_4582_9deb_be568b7d2dd6
is: P21912
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SDHB
is encoded by: hsa:6390
initial amount: NaN
boundary condition: true

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaM coa m
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57287
has only substance units: false
boundary condition: false
is: C00010
initial concentration: 1.0
name: Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110032#_c86a7a67_c736_4fa0_a7c4_f4ba57a76231
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2639
type: Species
is: Q92947
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: GCDH

http://identifiers.org/biomodels.db/MODEL1310110032#_3f354c30_a42b_4d47_a8f7_7c3fbdf8557b
type: Species
is: SBO:0000252
initial concentration: NaN
name: _U37519_1_c
is encoded by: hsa:U37519
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaM thbpt4acam c
is: HMDB02281
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:15374
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110032#_d10ead07_1385_433e_b525_535b0d5590cc
boundary condition: true
name: GPX1
initial amount: NaN
type: Species
is: P07203
is: SBO:0000252
is encoded by: hsa:2876
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_80ee6966_4dd6_4718_96c0_019468cb740e
type: Species
is: Q14435
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2591
name: GALNT3
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r1050
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_2df98304_2ec8_47c2_9869_f031088e3130
name: NDUFA7
constant: false
is: SBO:0000252
is encoded by: hsa:4701
is: Q6FG42
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR DTMPK
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000269
name: dTMP kinase
modifier: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM ksi deg26 l
name: keratan sulfate I, degradation product 26
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58343
is: HMDB00061
constant: false
initial amount: NaN
notes: FORMULA: C110H179N7O93S4 CHARGE: -4

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28701
boundary condition: false
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
is: HMDB06292
constant: false

metaR NDPK8
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110032#
type: Reaction

metaM ala B e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00056
initial amount: NaN
type: Species
name: beta-alanine
is: CHEBI:16958
boundary condition: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_41c44f83_45d5_4158_99bc_26350e4c93f1
boundary condition: true
name: NME2
type: Species
has only substance units: false
is: P22392
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4831

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR DGK1
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
is described by: ECO:0000269
reversible: true
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_b4c5443e_cb73_4243_b8e5_4df331cc0ea7
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q99944
name: EGFL8
has only substance units: false
type: Species
is encoded by: hsa:80864
initial concentration: NaN
constant: false

metaM taur e
is: CHEBI:3544
type: Species
is: C00245
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
has only substance units: false
is: HMDB00251
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Taurine

metaR r0909
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
name: Transport reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_09ca551f_5941_4403_90eb_637a2207fa29
is encoded by: hsa:160287
is: Q6ZMR3
initial amount: NaN
name: LDHAL6A
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR ABUTt2r
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
name: 4-aminobutyrate reversible transport in via proton symport
is described by: ECO:0000304
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_09d683c0_3aa3_4470_8a86_6862df1efaa4
name: ALAS1
is: Q5JAM2
is encoded by: hsa:211
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r1051
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
name: Vesicular transport
type: Reaction
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_5961b72e_566c_4df4_926e_5a41c616b28c
is: SBO:0000252
has only substance units: false
name: TPI1P2
is encoded by: hsa:286016
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_1b5b8925_6774_4fec_8805_f60766478251
is: P48728
initial concentration: NaN
initial amount: NaN
name: AMT
is encoded by: hsa:275
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR NDPK7
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dCDP)
is described by: ECO:0000269

metaM leuleu e
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: Leucylleucine
initial concentration: 1.0
constant: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/94244
boundary condition: false

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR r0908
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
product: MODEL1310110032#
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110032#

metaM 3hmp m
initial amount: NaN
name: 3-hydroxy-2-methylpropanoate
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00023
is: CHEBI:11805
type: Species
is: SBO:0000247

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110032#
is described by: ECO:0000269
name: Choline kinase

metaR r0208
reactant: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000

metaM nad c
is: CHEBI:57540
constant: false
name: Nicotinamide adenine dinucleotide
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00902
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
is: C00003

http://identifiers.org/biomodels.db/MODEL1310110032#_391ef8a0_2446_4825_80f3_db62c674ea12
is: Q53HE2
boundary condition: true
is encoded by: hsa:7167
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: TPI1

metaM for e
type: Species
is: HMDB00142
has only substance units: false
name: formate
is: CHEBI:15740
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaR URIt5le
name: uridine transport in via sodium symport (1:2)
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false
is: SBO:0000185
type: Reaction

metaM o2 e
is: HMDB01377
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
boundary condition: false
is: CHEBI:15379
has only substance units: false
name: O2
type: Species
is: C00007
is: SBO:0000247
constant: false

metaM arachdcrn c
is: HMDB01322
has only substance units: false
is: CHEBI:57387
name: C20:4 carnitine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
constant: false
initial amount: NaN

metaR r2202
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
type: Reaction

metaM gdp c
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
is: CHEBI:58189
is: HMDB01201
constant: false
is: SBO:0000247
is: C00035
initial amount: NaN
has only substance units: false

metaR NAGLCAly
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false
name: N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110032#
type: Reaction

metaR LEUTAm
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
reversible: true
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176

metaM HC00342 c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
is: CHEBI:16383
initial amount: NaN

metaR r2413
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110032#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR r0179
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

metaM apoC Lys c
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
name: Apocarboxylase (Lys residue)
is: HMDB00182
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_84362123_b815_4f24_8acf_7e6832dab335
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI620219
name: _AI620219_1_c
type: Species
has only substance units: false

metaM h2o m
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02111
boundary condition: false
has only substance units: false
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: C00001

metaR AHEXASEly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
product: MODEL1310110032#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ba1ea97a_1d9b_428d_9c5c_6e9f877f8e8c
has only substance units: false
is: Q96KJ9
is: SBO:0000252
boundary condition: true
name: COX4I2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84701
constant: false
type: Species

metaR SERtN1
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
name: Serine transport (Na, H coupled)
type: Reaction

metaM acald e
has only substance units: false
is: HMDB00990
is: SBO:0000247
is: CHEBI:15343
constant: false
boundary condition: false
name: acetaldehyde
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM HC00229 e
is: SBO:0000247
type: Species
name: Isomaltose
initial amount: NaN
constant: false
is: CHEBI:28189
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_29bdbd51_2822_4e0b_9bc5_3506503340bc
constant: false
boundary condition: true
name: GAL3ST1
is: Q99999
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9514
initial concentration: NaN
type: Species

metaM HC02206 c
is: CHEBI:57399
type: Species
initial amount: NaN
name: prostaglandin C1(1-)
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false

metaR ACt2m
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD

metaR TYRCBOX
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: L-Tyrosine carboxy-lyase
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000134
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e91a8b21_61c7_410b_adb2_ee1c9b0a8d18
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5106
is: SBO:0000252
name: PCK2
initial amount: NaN
is: Q16822
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_f0ce0082_ca09_4695_a568_eeced2f9e50a
is encoded by: hsa:8050
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: O00330
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDHX

metaM odecoa c
initial concentration: 1.0
is: CHEBI:3793
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
constant: false
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
has only substance units: false
initial amount: NaN

metaM for c
has only substance units: false
name: Formate
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial concentration: 1.0
is: CHEBI:15740
initial amount: NaN
is: HMDB00142
is: C00058
boundary condition: false
is: SBO:0000247
type: Species

metaR OCCOAtx
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#

metaR r0311
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
modifier: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
reversible: false
type: Reaction
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

metaM duri e
name: Deoxyuridine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16450
is: SBO:0000247
constant: false
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: HMDB00012
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_6b06079e_1078_4f47_a5ca_cb6cf14178b3
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5538
constant: false
initial amount: NaN
is: Q6FGQ4
name: PPT1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_3e01d1ce_b131_46a8_abfd_d3d8c530a5ac
is encoded by: hsa:AA081045
initial concentration: NaN
name: _AA081045_1_e
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM cgly e
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
is: HMDB00078
is: CHEBI:4047
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM h2o l
initial amount: NaN
is: CHEBI:15377
constant: false
has only substance units: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02111
type: Species

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b9f62561_3e1e_4053_a1c2_2510f1b59a11
is encoded by: hsa:F23536
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _F23536_1_m
constant: false
initial amount: NaN
initial concentration: NaN

metaM acgam c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: N-acetyl-D-glucosamine
has only substance units: false
is: CHEBI:17411
is: HMDB00215
constant: false

metaM cys L c
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
boundary condition: false
type: Species
is: HMDB00574
is: CHEBI:17561
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-cysteine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6e52d1e9_95bf_4938_81a8_73443ddd6b81
is: SBO:0000252
name: CHAT
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: D3DX95
is encoded by: hsa:1103
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_63730628_94ee_4165_8b83_7865d60255c1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: Q86SR1
is encoded by: hsa:55568
type: Species
boundary condition: true
is: SBO:0000252
name: GALNT10

metaR 2AMACHYD
name: 2-Aminoacrylate hydrolysis
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

metaR L LACt4r
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reversible: true
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_dced8a26_6254_4db9_8aa3_cfebde3497bc
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9P0J0
name: NDUFA13
boundary condition: true
type: Species
is encoded by: hsa:51079
has only substance units: false

metaR NACHEXA17ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0998
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
reversible: true

metaR DALAt2r
type: Reaction
reversible: true
modifier: MODEL1310110032#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is: SBO:0000185
is described by: ECO:0000304
fast: false

metaR PRASCS
reactant: MODEL1310110032#
type: Reaction
reversible: true
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
fast: false

metaR r0310
type: Reaction
reactant: MODEL1310110032#
reversible: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is: SBO:0000176

metaR RE2069C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
type: Reaction
is: SBO:0000176
name: RE2069
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_da02ac17_3429_4693_a894_6d144275e3f1
is encoded by: hsa:2805
is: SBO:0000252
type: Species
initial amount: NaN
name: GOT1
constant: false
is: P17174
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ea51bbe8_4e2a_4a10_a2da_9842f7bc1f55
constant: false
initial amount: NaN
is: P49914
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10588
initial concentration: NaN
type: Species
name: MTHFS

metaM gullac r
name: L-gulono-1,4-lactone
is: CHEBI:17587
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: HMDB03466
type: Species

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000

metaM ahcys c
has only substance units: false
name: S-Adenosyl-L-homocysteine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
constant: false
initial amount: NaN
is: C00021

metaM acald c
is: SBO:0000247
constant: false
has only substance units: false
name: acetaldehyde
type: Species
is: CHEBI:15343
is: HMDB00990
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false

metaM HC02206 e
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
initial concentration: 1.0
is: CHEBI:57399
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_891ad89f_80af_435f_96d1_6933f6060b04
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:285973
name: ATG9B
initial concentration: NaN
is: Q674R7

metaM pep c
is: CHEBI:18021
name: Phosphoenolpyruvate
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: HMDB00263
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaR GLUPRT
name: glutamine phosphoribosyldiphosphate amidotransferase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
reversible: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f16a66d6_a235_4904_be61_88ab385624b9
type: Species
name: ENTPD3
is: O75355
is encoded by: hsa:956
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_3b1fa6cf_5882_4613_b299_dbd96d70ee16
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9Y619
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10166
name: SLC25A15
boundary condition: true

metaR RE2659R
name: RE2659
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000176

metaM ptrc e
is: C00134
type: Species
is: HMDB01414
constant: false
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
is: CHEBI:326268
initial concentration: 1.0
name: Putrescine
boundary condition: false
has only substance units: false

metaR CBASPte
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of N-carbamoyl-L-aspartate
product: MODEL1310110032#
is described by: ECO:0000134
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_7114bbb3_3e01_4f3c_a2f4_2735ca45cb59
constant: false
is: Q9H015
type: Species
boundary condition: true
initial amount: NaN
name: SLC22A4
is encoded by: hsa:6583
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2201
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110032#

metaR RE1520M
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: RE1520
reactant: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110032#_9c9b6a4a_7e80_4b16_a3f4_be5d3d7d86f4
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: AUH
is: Q13825
is: SBO:0000252
constant: false
is encoded by: hsa:549

http://identifiers.org/biomodels.db/MODEL1310110032#_90724816_6857_4a1e_b5bd_23ae9a4d6a10
initial concentration: NaN
is encoded by: hsa:4842
is: B4DG68
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: NOS1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_0726ad30_d55b_4523_8821_22251f1fb7ea
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:4705
is: SBO:0000252
name: NDUFA10
constant: false
is: O95299
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d060cadb_1bd7_4ecb_874c_2551d7c8b059
constant: false
name: DUT
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1854
is: P33316

metaM cys L e
constant: false
has only substance units: false
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-cysteine

metaM glac r
initial concentration: 1.0
boundary condition: false
is: HMDB06355
has only substance units: false
name: D-glucurono-6,3-lactone
initial amount: NaN
type: Species
is: CHEBI:18268
is: SBO:0000247
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6f83fcf4_7a26_40cf_b461_b9bc2f7eb4ab
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: P19801
constant: false
is encoded by: hsa:26
initial concentration: NaN
name: ABP1

http://identifiers.org/biomodels.db/MODEL1310110032#_6d658470_ea91_4075_9566_39e334fbfb29
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _H45672_1_m
is encoded by: hsa:H45672
initial concentration: NaN
type: Species
boundary condition: true

metaM lnlccoa m
initial concentration: 1.0
is: HMDB01064
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
type: Species
name: linoleic coenzyme A
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
constant: false
has only substance units: false

metaR MTHFD
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP)
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
type: Reaction

metaR r1731
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR CYSTSERex
type: Reaction
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: false
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
name: L-cystine/glycine exchanger (cystine in)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_5f2b9a9b_a630_484a_87c1_62dac77662b5
is: B4DZR2
initial concentration: NaN
is encoded by: hsa:8854
type: Species
constant: false
is: SBO:0000252
name: ALDH1A2
initial amount: NaN
has only substance units: false
boundary condition: true

metaR BALAtmr
fast: false
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000

metaM udpgal e
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: UDP-D-galactose(2-)

metaR r1671
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true

metaM leuktrD4 c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03080
boundary condition: false
name: Leukotriene D4
is: CHEBI:28666
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaM ahcys e
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16680
constant: false
initial amount: NaN
is: HMDB00939
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
name: S-Adenosyl-L-homocysteine

metaM cdpdag hs c
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
is: CHEBI:58332
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: CDP-diacylglycerol(2-)

http://identifiers.org/biomodels.db/MODEL1310110032#_cbb547c9_dec2_452b_89f4_61e281eeb91c
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: P21953
is encoded by: hsa:594
name: BCKDHB
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM gdp g
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
type: Species
is: SBO:0000247
is: HMDB01201
name: GDP(3-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM coa e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00010
is: HMDB01423
constant: false
initial amount: NaN
type: Species
name: Coenzyme A
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_b4e39ce8_4bc8_482b_840f_8783601e2a18
is encoded by: hsa:1719
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: DHFR
is: P00374
constant: false
has only substance units: false
initial concentration: NaN

metaR r1487
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
type: Reaction
fast: false
name: EC:6.2.1.3
reversible: true
kinetic law: MODEL1310110032#

metaR NTD4e
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000134
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: 5'-nucleotidase (CMP), extracellular
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false

metaR MTHFC
reversible: true
is: SBO:0000176
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrofolate cyclohydrolase
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5

metaM i c
initial amount: NaN
name: iodide
is: SBO:0000247
constant: false
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: HMDB12238
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_7b5b4357_92cc_4851_9f66_1d1d5f7c9fbf
is: Q7Z4L0
type: Species
name: COX8C
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:341947
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1147
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_817a7d2c_b5ae_4e55_a6e2_6dc084906f48
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5805
constant: false
has only substance units: false
is: Q03393
name: PTS

metaR ACt2r
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
is described by: ECO:0000000
fast: false
name: acetate reversible transport via proton symport
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM dpcoa e
type: Species
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: SBO:0000247
name: Dephospho-CoA
is: HMDB01373
initial amount: NaN
is: CHEBI:57328
is: C00882
boundary condition: false
initial concentration: 1.0
constant: false

metaR r1670
reactant: MODEL1310110032#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ala D e
boundary condition: false
is: CHEBI:15570
type: Species
has only substance units: false
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
initial concentration: 1.0
name: D-alanine
is: SBO:0000247
initial amount: NaN

metaM dcsptn1coa x
boundary condition: false
is: SBO:0000247
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
type: Species
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_f6a8df13_c98e_4b58_92c6_ebff4663076d
is: SBO:0000252
has only substance units: false
name: ADSS
is: P30520
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:159
boundary condition: true
initial concentration: NaN

metaR HISTAtu
modifier: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: Histamine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR PPItx
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
name: Diphosphate transporter, peroxisome
fast: false
product: MODEL1310110032#
is: SBO:0000185

metaR r2080
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110032#
type: Reaction

metaR SPHS1Ptr
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: true
name: sphingosine-1-phosphate transport

http://identifiers.org/biomodels.db/MODEL1310110032#_8b414911_9f99_4987_9f03_9ddd45b1fd0d
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: Q9HCC0
has only substance units: false
initial amount: NaN
is encoded by: hsa:64087
name: MCCC2

metaM dctp c
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00998
constant: false
is: C00458
boundary condition: false
name: dCTP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_5f43c4a1_fe19_4064_8795_1972e79e93aa
name: DHCR7
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:1717
is: Q9UBM7
initial amount: NaN
type: Species
initial concentration: NaN

metaR r0994
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Facilitated diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185

metaR GGH 5DHFe
is: SBO:0000176
fast: false
product: MODEL1310110032#
reversible: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

metaR GNDer
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
name: phosphogluconate dehydrogenase, endoplasmic reticulum
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
kinetic law: MODEL1310110032#
type: Reaction

metaM leuktrD4 e
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB03080
is: CHEBI:28666
is: SBO:0000247
boundary condition: false
name: Leukotriene D4

http://identifiers.org/biomodels.db/MODEL1310110032#_190b331f_2fac_469f_9662_0fe6f3be5d3c
constant: false
is encoded by: hsa:AI601100
initial amount: NaN
boundary condition: true
name: _AI601100_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM o2 c
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: O2
type: Species
is: C00007
boundary condition: false
has only substance units: false
is: HMDB01377
constant: false

metaM s2l2fn2m2masn l
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C90H145N6O65X CHARGE: -2
type: Species
boundary condition: false
name: PA6
is: SBO:0000247
is: CHEBI:18287
constant: false
has only substance units: false
is: HMDB00174

http://identifiers.org/biomodels.db/MODEL1310110032#_8a4e1c20_1e31_4aa1_8926_e5b3f27919f6
constant: false
is encoded by: hsa:7498
type: Species
has only substance units: false
is: SBO:0000252
name: XDH
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P47989

http://identifiers.org/biomodels.db/MODEL1310110032#_b74b5104_be2c_440a_8e2f_644e876401ee
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P30838
is encoded by: hsa:218
boundary condition: true
initial concentration: NaN
name: ALDH3A1

metaM ala B m
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: beta-alanine
is: CHEBI:16958
has only substance units: false
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
constant: false

metaM succ m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00254
has only substance units: false
boundary condition: false
is: CHEBI:30031
name: Succinate
constant: false
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR CO2ter
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110032#
name: aspartate transaminase
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269

metaM pa hs r
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57739
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: phosphatidate(2-)

metaM 44mctr r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: SBO:0000247
boundary condition: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
type: Species
initial amount: NaN
is: HMDB01023
constant: false
is: CHEBI:17813

metaR r2081
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
is: HMDB01484
has only substance units: false
constant: false
is: C00332
type: Species
is: CHEBI:57286
name: Acetoacetyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR RE1517M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
name: RE1517
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
fast: false
product: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR BTNPL
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
is described by: ECO:0000000
name: holocarboxylase synthestase (biotin protein ligase)
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#

metaM coa c
boundary condition: false
initial concentration: 1.0
is: CHEBI:3312
is: SBO:0000247
is: C00010
is: HMDB01423
name: Coenzyme A
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4

metaR r0178
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
product: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_717c487d_4cf7_4d94_a2a3_b2c016f20fe7
constant: false
initial concentration: NaN
name: GUSB
boundary condition: true
initial amount: NaN
is: P08236
is: SBO:0000252
type: Species
is encoded by: hsa:2990
has only substance units: false

metaM pacald c
name: phenylacetaldehyde
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16424
has only substance units: false
is: SBO:0000247
is: HMDB06236
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601

metaR TDP
name: thiamin pyrophosphatase
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:2171493,PMID:8522961 NOTES:_01-25-05 IT AMF

metaR 4MOPte
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
product: MODEL1310110032#
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate

metaR NADPHtru
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110032#
name: NADPH transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110032#_923f0e00_8d1d_44c1_8b85_f0013bbeda30
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3417
is: O75874
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: IDH1

metaR NACHEX22ly
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM udpgal g
initial amount: NaN
is: CHEBI:58439
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00302
is: SBO:0000247
type: Species
name: UDP-D-galactose(2-)
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaM i e
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16382
name: iodide
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM hom L c
is: SBO:0000247
name: L-homoserine
is: CHEBI:15699
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_19a36317_6b44_407e_98f0_c0a226351416
is: O43677
name: NDUFC1
is encoded by: hsa:4717
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM dpcoa c
type: Species
constant: false
name: Dephospho-CoA
is: HMDB01373
is: SBO:0000247
initial amount: NaN
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
is: C00882
initial concentration: 1.0
has only substance units: false

metaM C04849 e
initial amount: NaN
boundary condition: false
is: CHEBI:57449
has only substance units: false
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: SBO:0000247
type: Species

metaM duri c
name: Deoxyuridine
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: HMDB00012
is: CHEBI:16450
constant: false
is: C00526
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM h2o n
is: CHEBI:15377
name: water
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02111
boundary condition: false
initial amount: NaN
constant: false

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
type: Species
constant: false
is: HMDB00078
initial concentration: 1.0
has only substance units: false
is: CHEBI:4047
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_7643449e_9170_45b5_8bd8_75263c57fec2
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P43353
name: ALDH3B1
constant: false
has only substance units: false
is encoded by: hsa:221

metaM ala D c
is: HMDB01310
initial amount: NaN
is: CHEBI:15570
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: D-alanine
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
constant: false

metaM ac c
name: acetate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: HMDB00042
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:30089

http://identifiers.org/biomodels.db/MODEL1310110032#_8200e5ac_9a68_413f_b35e_a6801e96c466
type: Species
boundary condition: true
is encoded by: hsa:2745
is: P35754
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: GLRX
is: SBO:0000252

metaM apoC m
type: Species
is: SBO:0000247
is: CHEBI:32551
is: HMDB00182
boundary condition: false
notes: FORMULA: XH CHARGE: 0
has only substance units: false
constant: false
initial amount: NaN
name: Apocarboxlase (no lys residue)
initial concentration: 1.0

metaR ITCOAL1m
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true

metaM guln c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03290
name: L-gulonate
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: CHEBI:13115
type: Species

metaR DM ethamp r
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR G5SADs
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:Needed in L-proline biosynthesis
is: SBO:0000176
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)

metaR UGALNACtg
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110032#
product: MODEL1310110032#
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b253c2b8_1d6c_4aa7_9cd6_abb8f33ae024
type: Species
is: E7EPT3
constant: false
has only substance units: false
is encoded by: hsa:501
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALDH7A1

metaM 5adtststerone e
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
initial concentration: 1.0
boundary condition: false

metaR RE3566C
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
type: Reaction
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
is: SBO:0000185
modifier: MODEL1310110032#
reversible: true
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM CE0849 m
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
is: CHEBI:57795
boundary condition: false

metaR r2083
fast: false
reversible: true
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
is: SBO:0000185

metaR CHATn
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
name: Choline O-acetyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110032#

metaR ACACT1rm
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110032#_1fbaf917_7c34_4b52_b52a_9e9cc8ac18c5
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:728441
initial concentration: NaN
initial amount: NaN
name: GGT2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_a239b0ec_8488_45c6_a8ce_faeb146bd577
is: SBO:0000252
constant: false
initial amount: NaN
name: NDUFA3
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O95167
type: Species
is encoded by: hsa:4696

metaR IDOAASE4ly
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
name: alpha-L-iduronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.76

http://identifiers.org/biomodels.db/MODEL1310110032#_5b7fcc92_467f_43f9_8760_1ade0a09bf2b
has only substance units: false
initial amount: NaN
is: P51648
boundary condition: true
name: ALDH3A2
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:224
initial concentration: NaN

metaR ARACHDt2
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d85f66dd_5a93_41b3_a9c9_574f2405e48e
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _FLJ44968_1_m
is encoded by: hsa:FLJ44968

metaR AMPDA
name: Adenosine monophosphate deaminase
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.6
is: SBO:0000176
fast: false
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_532cb3d6_4551_4d09_a873_f129cc33712f
constant: false
is: Q9NQR4
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56954
type: Species
name: NIT2
initial amount: NaN

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:12947
type: Species
name: D-galactosyl-N-acylsphingosine

metaR SIAT4Bg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110032#
fast: false
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110032#
is: SBO:0000176

metaM vitd3 c
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: calciol
is: HMDB00876
initial amount: NaN
is: CHEBI:28940
boundary condition: false

metaR r2082
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110032#

metaM hista e
initial amount: NaN
has only substance units: false
is: HMDB00870
boundary condition: false
is: CHEBI:58432
name: histamium
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
constant: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM o2 m
is: SBO:0000247
is: C00007
is: CHEBI:15379
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
boundary condition: false
name: O2
initial concentration: 1.0
is: HMDB01377
constant: false
initial amount: NaN

metaR r0186
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reversible: false
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
modifier: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_53ff74e1_b42e_4cb4_a9a3_d954ec687ead
name: CPT2
type: Species
is: P23786
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252
initial amount: NaN

metaR r0033
product: MODEL1310110032#
is described by: ECO:0000000
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
kinetic law: MODEL1310110032#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176

metaM 5fthf m
initial amount: NaN
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57457
constant: false
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)

metaM ac e
has only substance units: false
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
boundary condition: false
constant: false
type: Species
is: CHEBI:30089
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_48cb09dc_cd5a_4f73_ac3a_3430285e6d8d
name: COX6A1
initial concentration: NaN
boundary condition: true
type: Species
is: P12074
is encoded by: hsa:1337
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM coa x
is: C00010
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01423
is: SBO:0000247
is: CHEBI:57287
constant: false
name: Coenzyme A
initial concentration: 1.0
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR CITtam
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
name: citrate transport, mitochondrial
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM cala c
is: CHEBI:11892
initial concentration: 1.0
initial amount: NaN
name: N-carbamoyl-beta-alaninate
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: HMDB00026
type: Species

metaM arach e
boundary condition: false
type: Species
constant: false
is: HMDB02212
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:32360

metaM HC02210 e
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
has only substance units: false
name: prostaglandin-d3
initial amount: NaN
constant: false

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
name: glycerol transport
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b97adf95_285b_43ce_9b0b_b9562ae1f00e
boundary condition: true
name: TMEM91
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:641649
has only substance units: false
constant: false
is: C9JZ62
is: SBO:0000252

metaR r2085
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110032#
type: Reaction
reversible: true
modifier: MODEL1310110032#

metaR r1527
reversible: false
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.1
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110032#
is: SBO:0000185

metaM gly x
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:15428
constant: false
has only substance units: false
name: glycine
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: HMDB00123
initial amount: NaN

metaR r0779
fast: false
is: SBO:0000176
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110032#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
type: Reaction
kinetic law: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is described by: ECO:0000000

metaM odecoa m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57387
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
is: HMDB01322
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Octadecenoyl-CoA (n-C18:1CoA)

http://identifiers.org/biomodels.db/MODEL1310110032#_04ccbb4c_4142_4e29_a96e_05a013c52e82
is encoded by: hsa:AI222095
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _AI222095_1_e
initial amount: NaN
initial concentration: NaN

metaR r0317
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
reversible: true
kinetic law: MODEL1310110032#

metaR TYRt
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110032#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
name: L-tyrosine transport

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
initial concentration: 1.0
is: HMDB00230
is: CHEBI:35418
is: SBO:0000247
name: N-acetylneuraminate
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f410392e_0b67_42c5_ae92_adeaf40e4732
is: P19961
constant: false
is: SBO:0000252
initial amount: NaN
name: AMY2B
initial concentration: NaN
is encoded by: hsa:280
has only substance units: false
type: Species
boundary condition: true

metaR SFCYSc
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
reversible: true
reactant: MODEL1310110032#
fast: false
name: Formation of sulfocysteine
is: SBO:0000176

metaR SPHS1Pte
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110032#

metaR TALA
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.2
name: transaldolase
fast: false
reversible: true

metaR r1150
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fabe07dc_8e9f_46ac_9af8_2b5805fad495
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
constant: false
is encoded by: hsa:7991
has only substance units: false

metaR LACZe
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.108
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is: SBO:0000176
name: b-galactosidase, extracellular
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaR r2084
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_afc86e2b_ae32_4d8c_b097_12a343d2f912
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:126
constant: false
is: SBO:0000252
is: P00326
type: Species
initial concentration: NaN
name: ADH1C

http://identifiers.org/biomodels.db/MODEL1310110032#_bcab967e_9495_4cf2_a88e_f64873cbff0a
initial concentration: NaN
name: AOC2
boundary condition: true
is encoded by: hsa:314
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR CYTK1n
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110032#
name: cytidylate kinase (CMP),nuclear
fast: false
modifier: MODEL1310110032#
is: SBO:0000176
type: Reaction

metaM vitd3 e
is: HMDB00876
initial concentration: 1.0
is: CHEBI:28940
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
name: calciol
initial amount: NaN
has only substance units: false
type: Species

metaR r0399
modifier: MODEL1310110032#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110032#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

metaM dhor S c
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: (S)-dihydroorotate
is: HMDB03349
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: SBO:0000247
is: CHEBI:30864

metaM arach c
is: HMDB02212
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
constant: false
name: arachidate
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM HC02210 c
type: Species
is: CHEBI:34939
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: prostaglandin-d3
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_31a46efd_0ece_4edd_b984_7e0818a70a71
type: Species
is encoded by: hsa:83594
is: Q9BQG2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: NUDT12
initial concentration: NaN

metaR r0394
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
product: MODEL1310110032#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:

metaR NDPK5n
modifier: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_837b7c09_a4c7_489b_b072_177c9d03babf
is: P43353
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: ALDH3B1
is encoded by: hsa:221
is: SBO:0000252
constant: false
has only substance units: false

metaM f6p c
is: http://identifiers.org/pubchem.compound/3385
has only substance units: false
initial concentration: 1.0
type: Species
is: C00085
is: HMDB00124
name: D-Fructose 6-phosphate
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57579

http://identifiers.org/biomodels.db/MODEL1310110032#_4bad6cb6_7029_4b03_82c7_9c5d69122cce
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: ENTPD1
is: Q86VV3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:953

http://identifiers.org/biomodels.db/MODEL1310110032#_d6573b0b_623b_4e8a_be2d_f2cb288d8aa2
initial amount: NaN
is: P07864
name: LDHC
boundary condition: true
has only substance units: false
is encoded by: hsa:3948
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR OCDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
name: fatty acid transport via diffusion
is: SBO:0000185

metaR RE1573M
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
name: RE1573
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction

metaR MCCCrm
is: SBO:0000176
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
name: methylcrotonoyl-CoA carboxylase, mitochondrial
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.4.1.4
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2b0aab5a_9bc4_4cb7_b5ec_5f200e9a7f97
is: Q548A7
name: SLC26A6
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:65010
initial concentration: NaN

metaM ksi deg35 l
type: Species
name: keratan sulfate I, degradation product 35
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00143

metaR r2087
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110032#
type: Reaction
reversible: true

metaM phe L e
is: HMDB00159
is: CHEBI:17295
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: L-phenylalanine
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

http://identifiers.org/biomodels.db/MODEL1310110032#_5e5b01ad_c142_4032_9e4c_6d0d0dda5b55
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:R39999
initial amount: NaN
constant: false
name: _R39999_1_c

metaR r1400
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110032#

metaM tchola x
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
constant: false
is: SBO:0000247
initial amount: NaN
name: taurocholate
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:36257
is: HMDB00036

metaM but e
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17968
constant: false
name: butyrate
initial concentration: 1.0
boundary condition: false
is: HMDB00039
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b2380b1b_0860_485d_9c89_ddeff5ea8190
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1607
is: Q9Y6T7
type: Species
initial concentration: NaN
has only substance units: false
name: DGKB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_5475b429_3185_44cf_ad5e_3e1ebcef74bd
constant: false
is: O95436
type: Species
name: SLC34A2
is encoded by: hsa:10568
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR NADS2
name: NAD synthase (glutamine-hydrolysing)
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110032#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.1

metaM bilglcur e
is: CHEBI:57767
type: Species
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110032#_fa04ca83_4a6c_41cd_81d5_2abde4cc22bc
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9BY07
name: SLC4A5
is encoded by: hsa:57835
is: SBO:0000252

metaM glyc e
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00131
name: Glycerol
type: Species
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
is: C00116
has only substance units: false
is: SBO:0000247

metaR SFCYSe
name: Exit of sulfocysteine into extra-cellular space
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
fast: false
is described by: ECO:0000134
reversible: true

metaR DNDPt11m
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dGDP antiport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR r0393
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
modifier: MODEL1310110032#
type: Reaction

metaM gluala e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 5-L-Glutamyl-L-alanine
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
constant: false
is: HMDB06248
is: SBO:0000247
type: Species
is: C03740
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503

metaM chlstol r
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
constant: false
is: CHEBI:16290
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06842

http://identifiers.org/biomodels.db/MODEL1310110032#_e65f52d6_b06c_4cd1_850d_099b78a351fe
has only substance units: false
is encoded by: hsa:3283
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: HSD3B1
is: P14060
constant: false

metaR HISCAT1
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM ncam c
is: SBO:0000247
boundary condition: false
is: C00153
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide
is: HMDB01406
has only substance units: false
type: Species
constant: false
is: CHEBI:0
notes: FORMULA: C6H6N2O CHARGE: 0

metaR UGLT
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.7.12
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#
name: UDPglucose--hexose-1-phosphate uridylyltransferase

metaR 3MOPte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
fast: false
name: Transport of 3-methyl-2-oxopentanoate
is: SBO:0000185

metaR MTHFD2m
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000254
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
type: Reaction

metaM dcholcoa c
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06292
type: Species
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
boundary condition: false

metaR r2086
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_f13eaaa7_539c_45b2_97b9_3a2f5fc7e639
is encoded by: hsa:25769
has only substance units: false
name: SLC24A2
constant: false
initial concentration: NaN
is: Q9UI40
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM hdd2coa m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA
constant: false
is: C05272
is: HMDB03945
type: Species
initial concentration: 1.0
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272

http://identifiers.org/biomodels.db/MODEL1310110032#_8617aad8_44dd_4c25_a091_eaf4a6f629e4
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC6A8
is encoded by: hsa:6535
boundary condition: true
is: SBO:0000252
has only substance units: false
is: B4DIA3
type: Species

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_14b5257a_62be_448f_84b1_f705a0e79560
constant: false
boundary condition: true
is: P00918
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: CA2
is encoded by: hsa:760

http://identifiers.org/biomodels.db/MODEL1310110032#_33d5a1ad_5c3c_45fd_be52_e9a7718e6958
initial amount: NaN
name: BLVRB
is encoded by: hsa:645
is: P30043
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaM s2l2fn2m2masn e
constant: false
is: C00255
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: CHEBI:3554
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: PA6
type: Species
is: HMDB00244
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_bdc6d790_9413_4627_8aca_fce3f1078c17
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: ALDH1A3
boundary condition: true
is: P47895
initial concentration: NaN
is encoded by: hsa:220

metaM CE1944 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:36781
name: 1-pyrrolinium
constant: false
initial concentration: 1.0

metaM phe L c
is: HMDB00159
is: CHEBI:17295
is: SBO:0000247
has only substance units: false
name: L-phenylalanine
type: Species
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_00639e64_709e_435a_82c7_b6e7dee877bc
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
initial concentration: NaN
is: Q308M7
name: ENPP3
constant: false
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_077a2627_d0eb_49a9_a466_b3a9105bf01c
boundary condition: true
is encoded by: hsa:AA081045
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AA081045_1_c
constant: false

metaR r2089
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
fast: false

metaR r1492
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
name: Utilized transport
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110032#
is: SBO:0000185

metaR ACNAMlt
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is: SBO:0000185
reversible: true
modifier: MODEL1310110032#
name: N-acetylneuraminate transport into lysososme
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM ditp c
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
constant: false
is: HMDB03537
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: dITP(4-)
initial amount: NaN

metaM but c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00039

metaM dha e
has only substance units: false
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882
name: glycerone
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR DRPA
fast: false
reactant: MODEL1310110032#
name: deoxyribose-phosphate aldolase
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_583330b6_b419_445e_b01e_8fb44cc51bbd
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P11498
is: SBO:0000252
initial amount: NaN
name: PC
is encoded by: hsa:5091

metaM asp D x
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: HMDB06483
has only substance units: false
is: CHEBI:29990
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: D-aspartate(1-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ee02ad8a_de3b_41e5_9fc1_732b8b237b2d
constant: false
is: E7EML0
initial concentration: NaN
is encoded by: hsa:9498
type: Species
boundary condition: true
is: SBO:0000252
name: SLC4A8
initial amount: NaN
has only substance units: false

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
kinetic law: MODEL1310110032#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true

metaM hista c
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
has only substance units: false
is: CHEBI:58432
type: Species
initial concentration: 1.0
is: HMDB00870
constant: false

metaR FAOXC12C10x
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a8917bc9_783c_4eaf_b313_49191475c758
name: PGK2
type: Species
has only substance units: false
is: P07205
initial amount: NaN
is encoded by: hsa:5232
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM ncam e
is: C00153
initial amount: NaN
boundary condition: false
is: HMDB01406
initial concentration: 1.0
name: Nicotinamide
constant: false
type: Species
is: CHEBI:0
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247

metaM 10fthf5glu e
name: 10-formyltetrahydrofolate-[Glu](5)
is: CHEBI:57454
type: Species
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
constant: false
boundary condition: false
has only substance units: false
is: HMDB00972
is: SBO:0000247
initial concentration: 1.0

metaM dcsptn1coa c
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C16173
initial concentration: 1.0

metaR CYSGLYexR
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
is: SBO:0000185
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
fast: false

metaM retinal cis 13 r
boundary condition: false
initial amount: NaN
is: HMDB06220
type: Species
has only substance units: false
is: CHEBI:45487
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal

http://identifiers.org/biomodels.db/MODEL1310110032#_9de4f70c_535f_45e4_92f7_0a302535a362
name: SLC25A12
constant: false
is: SBO:0000252
is encoded by: hsa:8604
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O75746
type: Species
boundary condition: true

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110032#

metaM met L c
boundary condition: false
name: L-methionine
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16643
type: Species
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false

metaR MALT
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
name: alpha-glucosidase
reversible: false
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_a96f6973_b488_45f5_8613_810db404840c
is: SBO:0000252
is encoded by: hsa:T83654
boundary condition: true
initial concentration: NaN
name: _T83654_1_m
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_19ab85e3_84d4_4f9c_9b39_69d00a465603
initial amount: NaN
name: PCBD2
has only substance units: false
boundary condition: true
is: Q9H0N5
type: Species
is encoded by: hsa:84105
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_e86faf94_ab57_4699_8b9d_dfbce56e545e
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:51205
is: Q9NPH0
boundary condition: true
type: Species
name: ACP6
initial concentration: NaN

metaR NACHEXA2ly
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5949931d_0db0_4dbe_ac5b_428620639535
is encoded by: hsa:122970
initial amount: NaN
name: ACOT4
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: Q8N9L9

http://identifiers.org/biomodels.db/MODEL1310110032#_c6d29db7_64dc_40ca_ad59_a170e2329368
is encoded by: hsa:501
name: ALDH7A1
is: E7EPT3
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaR ADNt
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
name: adenosine facilated transport in cytosol
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_5ca73b00_341a_48bf_91bb_913562a3d7cf
boundary condition: true
is: Q96CA6
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: ACAA1
initial amount: NaN
is encoded by: hsa:30

metaM galside hs e
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:12947
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false

metaM taur c
constant: false
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
initial concentration: 1.0
is: HMDB00251
is: C00245
boundary condition: false
is: CHEBI:3544
name: Taurine
type: Species
initial amount: NaN
is: SBO:0000247

metaR NACDe
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR r1260
type: Reaction
kinetic law: MODEL1310110032#
reversible: false
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: EC:6.2.1.3
fast: false

metaM dcsptn1coa m
constant: false
is: C16173
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
is: HMDB06513
boundary condition: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
type: Species

metaR r2535
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110032#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110032#
fast: false

metaM gullac c
is: CHEBI:17587
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: HMDB03466
name: L-gulono-1,4-lactone

metaM met L e
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16643
is: HMDB00696
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_1788281c_c718_4c0a_adf8_e28c5a96f67d
type: Species
is encoded by: hsa:250
is: SBO:0000252
is: P05187
name: ALPP
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR GSNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: guanosine facilated transport in cytosol
is described by: ECO:0000269
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_122c3dd8_a6d3_41ea_bb48_db221766fb9c
constant: false
name: TK1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P04183
is encoded by: hsa:7083
initial concentration: NaN

metaM hco3 c
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
initial amount: NaN
has only substance units: false
constant: false
name: Bicarbonate
is: CHEBI:17544
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00288
boundary condition: false

metaR r0425
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: EC:1.1.1.42
is described by: ECO:0000000
reversible: true

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaM fuc1p L c
type: Species
name: L-Fucose 1-phosphate
initial concentration: 1.0
is: CHEBI:28319
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01265
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
constant: false

metaM ala B c
initial amount: NaN
type: Species
name: beta-alanine
is: CHEBI:16958
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
initial concentration: 1.0
boundary condition: false

metaR ACGAMK
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.59
reversible: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
name: N-acetylglucosamine kinase
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2ef62bc6_1993_40a1_871c_394668a25e39
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: TXNRD1
initial amount: NaN
is encoded by: hsa:7296
is: Q16881
has only substance units: false

metaM spc hs e
name: sphingosylphosphorylcholine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM 4abutn c
type: Species
initial amount: NaN
is: CHEBI:58264
is: HMDB01080
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
has only substance units: false
name: 4-Aminobutanal
constant: false
is: C00555
is: SBO:0000247

metaR r2538
fast: false
reversible: true
reactant: MODEL1310110032#
type: Reaction
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_28574d3a_fde2_4f21_93dc_f44d9032b718
is: Q99884
constant: false
is encoded by: hsa:6534
boundary condition: true
name: SLC6A7
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaM galside hs g
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947

metaM nrpphr e
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:33569
constant: false
boundary condition: false
name: Norepinephrine
is: HMDB00216

metaR G6PDH2rer
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
product: MODEL1310110032#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110032#
type: Reaction
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ab5d27b0_382c_4028_8d17_c80d677920df
boundary condition: true
type: Species
is: P42765
name: ACAA2
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10449

http://identifiers.org/biomodels.db/MODEL1310110032#_e8c8758a_35ec_46f7_bb51_9010f3d8a9c4
name: SLC25A6
is: SBO:0000252
is: Q6I9V5
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:293
type: Species
boundary condition: true
initial concentration: NaN

metaR RE1836X
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: RE1836
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0804a10c_123d_46b3_b1d2_e9fa01cb856e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51727
is: B2R6S5
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: CMPK1

metaR r0666
reversible: true
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
kinetic law: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reactant: MODEL1310110032#

metaM 5htrp e
initial amount: NaN
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
has only substance units: false
constant: false
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
is: HMDB00472
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR PI34P5K
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110032#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000

metaM ac m
is: CHEBI:30089
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
type: Species
has only substance units: false
name: acetate
initial amount: NaN
initial concentration: 1.0
is: HMDB00042
constant: false

metaM clpn hs c
initial amount: NaN
constant: false
is: CHEBI:21338
name: clpn_hs[c]
notes: FORMULA: CHARGE: 0
is: HMDB02704
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r1262
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
name: EC:6.2.1.3
type: Reaction

metaR r1384
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110032#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaM spc hs c
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
boundary condition: false
name: sphingosylphosphorylcholine
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5311445
constant: false
initial concentration: 1.0
initial amount: NaN

metaR DURAD
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8768b205_dc6a_4a4b_aafd_1f937893c688
constant: false
is encoded by: hsa:84812
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PLCD4
is: Q9BRC7
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_48bfdd36_6e6c_4018_8b2d_342addefd2a2
type: Species
initial amount: NaN
has only substance units: false
name: GALK2
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2585
initial concentration: NaN

metaR r2537
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Utilized transport
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_d99c3010_4b98_48b3_a19f_e0259e9af175
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AL048840
name: _AL048840_1_c
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_730c2c28_be9d_47b7_91c0_b1d2d1cadb46
is encoded by: hsa:AI348006
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: _AI348006_1_c
constant: false
is: SBO:0000252
initial amount: NaN

metaM acglcgalgluside hs g
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17103
has only substance units: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
initial amount: NaN
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
boundary condition: false

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM hco3 e
is: SBO:0000247
is: CHEBI:17544
initial amount: NaN
type: Species
has only substance units: false
name: Bicarbonate
is: HMDB00595
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
is: C00288
initial concentration: 1.0

metaM coa n
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01423
name: coenzyme A(4-)
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR DM dttp m
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b9de7d86_6d75_4f48_9fe8_1b375cf61d6b
has part: Q7GXZ1
is encoded by: hsa:4705
has part: O95299
has part: O95139
is encoded by: hsa:4723
has part: Q16718
has part: P56181
has part: P19404
is encoded by: hsa:51079
has part: Q13454
type: Species
has part: C9JT23
has part: O43677
has part: O95169
is: SBO:0000297
has part: O43678
has part: F8VQS7
is encoded by: hsa:55967
is encoded by: hsa:4725
has part: P28331
is encoded by: hsa:4720
has part: O43674
is encoded by: hsa:4707
is encoded by: hsa:4539
has part: P03915
is encoded by: hsa:374291
has part: P03897
has part: Q16795
is encoded by: hsa:4716
is encoded by: hsa:4696
is encoded by: hsa:4700
is encoded by: hsa:4717
has part: Q6IBC4
has part: Q7GXZ4
has part: H7C5B8
is encoded by: hsa:4728
is encoded by: hsa:4702
is encoded by: hsa:4710
has part: P17568
is encoded by: hsa:4726
is encoded by: hsa:4731
has part: O95168
is encoded by: hsa:4708
is encoded by: hsa:4537
has part: O43181
has only substance units: false
has part: O95167
is encoded by: hsa:4541
is encoded by: hsa:4694
is encoded by: hsa:4697
has part: E5KNH5
has part: O14561
is encoded by: hsa:4718
is encoded by: hsa:4711
has part: Q9P0J0
is encoded by: hsa:126328
constant: false
is encoded by: hsa:4535
has part: Q6IB80
initial amount: NaN
is encoded by: hsa:4704
is encoded by: hsa:4713
has part: A8K761
is encoded by: hsa:4701
has part: Q6IBA0
has part: Q549M5
is encoded by: hsa:4540
has part: B7Z792
is encoded by: hsa:4724
has part: Q6FG42
has part: O00217
is encoded by: hsa:4729
is encoded by: hsa:4719
has part: Q85KV6
has part: O75251
is encoded by: hsa:4538
initial concentration: NaN
is encoded by: hsa:4698
has part: P56556
has part: Q9Y6M9

metaR r0423
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110032#
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110032#

metaR 5ADTSTSTERONEte
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: 5 alpha dihydrotesterone transport
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_4bc82be5_9668_4d47_aafc_8b79b27512fb
name: ADH7
is: SBO:0000252
is encoded by: hsa:131
initial amount: NaN
constant: false
has only substance units: false
is: P40394
type: Species
initial concentration: NaN
boundary condition: true

metaR NAHCO3 HCLt
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_60b0a73f_eff7_4a0b_a918_09f171df88d5
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q9H1K4
is encoded by: hsa:83733
is: SBO:0000252
constant: false
name: SLC25A18
has only substance units: false

metaM o2 x
boundary condition: false
is: C00007
has only substance units: false
is: HMDB01377
name: O2
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379

metaM glyc c
is: C00116
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
constant: false
initial amount: NaN
type: Species
is: CHEBI:17754
is: HMDB00131
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR DIGALSIDEtg
reversible: true
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
is described by: ECO:0000000
name: digalside hs intracellular transport
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185

metaM bilglcur c
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: CHEBI:57767
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_fa0616ad_e30a_4b5d_a9a1_c63ba945b2af
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
has part: Q9UM01
name: SLC3A1:SLC7A7
is encoded by: hsa:9056
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110032#_e3c81815_3be5_4f22_9cc6_32b2c75297c3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:2181
boundary condition: true
name: ACSL3
initial amount: NaN
type: Species
is: O95573

metaR r0202
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is: SBO:0000176
reactant: MODEL1310110032#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

metaM pro L m
has only substance units: false
is: HMDB00162
type: Species
initial amount: NaN
is: CHEBI:17203
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
initial concentration: 1.0
constant: false
name: L-proline

metaR r0668
reversible: true
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
product: MODEL1310110032#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.4.2.19
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#

metaR CYTK1m
reversible: true
name: cytidylate kinase (CMP),mitochondrial
product: MODEL1310110032#
is: SBO:0000176
fast: false
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
is described by: ECO:0000134
kinetic law: MODEL1310110032#

metaR r2532
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_479fb9a9_5457_4658_af75_2df449ae207c
is encoded by: hsa:AV727634
initial concentration: NaN
has only substance units: false
name: _AV727634_1_c
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: L-aspartate(1-)
is: CHEBI:29991
type: Species
is: HMDB00191
initial concentration: 1.0
constant: false

metaM nrpphr c
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:33569
type: Species
is: HMDB00216
name: Norepinephrine
constant: false
initial concentration: 1.0

metaM ditp n
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
constant: false
initial amount: NaN
name: dITP(4-)
is: HMDB03537
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:61382
is: SBO:0000247
has only substance units: false

metaR ACOAD10m
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110032#

metaR r0801
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
name: 4-ammoniobutanal
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB01080
initial amount: NaN
is: SBO:0000247

metaR ILEt5m
fast: false
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Isoleucine mitochondrial transport

metaR RE0383C
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reversible: true
type: Reaction
fast: false
name: RE0383
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000000
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaR SERDGLNexR
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000304
type: Reaction
fast: false
name: D-Serine/Glutamine reversible exchange

metaR RNDR3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
reactant: MODEL1310110032#
reversible: false
is: SBO:0000176
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
name: ribonucleoside-diphosphate reductase (CDP)

metaM dhdascb e
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58070
name: dehydroascorbide(1-)
is: HMDB01264
constant: false
type: Species

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110032#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
name: RE1532
is: SBO:0000176

metaR DNDPt33m
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
type: Reaction
fast: false
name: dGDP transport via dUDP antiport
is: SBO:0000185

metaR DURIK1
name: deoxyuridine kinase (ATP:Deoxyuridine)
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
kinetic law: MODEL1310110032#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110032#
is described by: ECO:0000254

metaR NDPK1
kinetic law: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
product: MODEL1310110032#
type: Reaction

metaM mi1p D c
is: HMDB02985
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58433

http://identifiers.org/biomodels.db/MODEL1310110032#_b19f2a24_cb52_4207_8992_684b69b3d1c6
is encoded by: hsa:763
is: P35218
name: CA5A
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM CE2432 m
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57795
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
initial concentration: 1.0
boundary condition: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fc421d04_3b8a_4c94_8e0b_3e29665aedb7
initial amount: NaN
boundary condition: true
is: Q02742
is encoded by: hsa:2650
type: Species
has only substance units: false
constant: false
name: GCNT1
is: SBO:0000252
initial concentration: NaN

metaM 4mop m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
initial amount: NaN
is: CHEBI:17865
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB00695

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_29e9d777_5dfa_45ba_80d4_95e7208b47e0
name: NDUFA7
is encoded by: hsa:4701
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q6FG42
constant: false

metaR r0669
reactant: MODEL1310110032#
fast: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110032#
type: Reaction

metaM CE0693 m
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB11123
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial amount: NaN
is: SBO:0000247
name: 3-oxolaur-6-cis-enoyl-CoA
type: Species
is: CHEBI:28387

metaM thbpt4acam n
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02281
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin

http://identifiers.org/biomodels.db/MODEL1310110032#_479d476b_c731_4fae_8ba8_621726e2b377
initial amount: NaN
initial concentration: NaN
type: Species
name: DGKH
has only substance units: false
is encoded by: hsa:160851
is: Q86XP1
boundary condition: true
constant: false
is: SBO:0000252

metaM n2m2nmasn e
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: C04946
initial amount: NaN
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0

metaR ASPTAm
kinetic law: MODEL1310110032#
name: aspartate transaminase
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_ff6c0e3e_42a5_4266_b1dc_8b029c4b14b7
is encoded by: hsa:NOS2A
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: _NOS2A_1_e
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_e1c4245a_ad73_448e_b5f6_ca4f3849e4f6
name: CTH
is: SBO:0000252
is encoded by: hsa:1491
type: Species
constant: false
initial concentration: NaN
is: B4E1R2
has only substance units: false
boundary condition: true
initial amount: NaN

metaM asp L c
is: SBO:0000247
type: Species
name: L-aspartate(1-)
is: HMDB00191
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:29991
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false

metaR r0426
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.34
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaM o2 r
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
initial concentration: 1.0
boundary condition: false
is: C00007
name: O2
is: SBO:0000247
is: CHEBI:15379
is: HMDB01377
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3691537d_7320_44d2_9385_afa26fcebf6b
name: B3GALT5
has only substance units: false
is encoded by: hsa:10317
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1956
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
is: SBO:0000185
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Y+LAT2 Utilized transport

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
name: RE1527
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaR RE1796R
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110032#
reversible: true
name: RE1796
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false

metaR r2309
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true

metaR r2534
product: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
reactant: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaM dhdascb c
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: dehydroascorbide(1-)
is: SBO:0000247
is: CHEBI:58070
type: Species
is: HMDB01264
constant: false

metaR RNDR1
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (ADP)

metaM 34dhoxmand m
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
constant: false
name: 3,4-Dihydroxymandelate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:27637

metaM galside hs c
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:12947
type: Species
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
boundary condition: false
name: D-galactosyl-N-acylsphingosine

metaR SUCOAS1m
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Succinate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR r0295
product: MODEL1310110032#
reactant: MODEL1310110032#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is: SBO:0000176
reversible: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
type: Reaction

metaR NDP7g
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus

metaR IDPtn
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: IDP nuclear transport
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e1e189e0_206a_43e1_84f6_39b6234da5ad
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA576959
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: _AA576959_1_c
boundary condition: true

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM odecoa r
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387
initial amount: NaN
name: oleoyl-CoA(4-)
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01322

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR AGTim
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.44
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false
is described by: ECO:0000269

metaM coa r
is: CHEBI:57287
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: C00010
has only substance units: false
boundary condition: false
is: HMDB01423
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM c12dccoa x
has only substance units: false
name: dodecanedioylcoa
is: C14143
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
is: SBO:0000247
is: HMDB04047
constant: false

metaR TRDRm
is described by: ECO:0000269
type: Reaction
name: thioredoxin reductase (NADPH)
is: SBO:0000176
fast: false
modifier: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_3aeebb99_1eec_427a_9a2f_99880917f30b
is: P19367
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3098
constant: false
is: SBO:0000252
name: HK1
type: Species
initial amount: NaN
has only substance units: false

metaR RE2666C
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: RE2666
fast: false
is described by: ECO:0000000

metaR DM fol
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM 4nphsf e
initial concentration: 1.0
name: 4-Nitrophenyl sulfate
type: Species
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06492
has only substance units: false
is: CHEBI:35422
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ddc6431a_873f_453c_bfa2_0d939362b5ea
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q01959
is encoded by: hsa:6531
constant: false
type: Species
initial amount: NaN
name: SLC6A3
boundary condition: true

metaR r0470
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
reversible: true

metaM orn e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
is: HMDB00214
initial amount: NaN
type: Species
is: CHEBI:0
constant: false
is: SBO:0000247
boundary condition: false
is: C01602

metaR r1453
product: MODEL1310110032#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110032#
reversible: true
is: SBO:0000176

metaR DTDPtn
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
name: dTDP nuclear transport
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000

metaR ALAGLYexR
fast: false
reactant: MODEL1310110032#
name: L-alanine/glycine reversible exchange
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR r0558
fast: false
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110032#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_ea57cce0_e529_42e8_91ef_d42255b13231
constant: false
is: SBO:0000252
is encoded by: hsa:H17063
type: Species
boundary condition: true
name: _H17063_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_980391dc_b2db_425a_9be3_5ca7de3bd7d5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1609
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: DGKQ
is: P52824

http://identifiers.org/biomodels.db/MODEL1310110032#_bc8df5e9_db41_4abc_a045_a9e1b615256f
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5313
name: PKLR
is: P30613
boundary condition: true
is: SBO:0000252

metaR CITt4 4
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
name: citrate transport via sodium symport
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
fast: false

metaR NACHEX2ly
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110032#

metaM pro D c
is: HMDB03411
initial concentration: 1.0
type: Species
is: CHEBI:16313
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
has only substance units: false

metaM arachdcrn x
is: SBO:0000247
is: HMDB06523
name: C20:4 carnitine
has only substance units: false
initial concentration: 1.0
is: CHEBI:57368
constant: false
boundary condition: false
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN

metaR COAtl
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
name: CoA transport in lysosome via diffusion
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
reversible: true
type: Reaction
reactant: MODEL1310110032#

metaR DAGK hs
type: Reaction
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110032#_b8580c8b_dd2d_4afc_9beb_b4fad31b55af
constant: false
name: ACAA1
is: SBO:0000252
is encoded by: hsa:30
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: Q96CA6
has only substance units: false

metaR GGH 10FTHF5GLUe
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110032#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
modifier: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

http://identifiers.org/biomodels.db/MODEL1310110032#_84e49a8e_371e_44e9_a347_43e6a14aa56d
type: Species
name: GGCT
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79017
has only substance units: false
is: B8ZZR8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_dbd9c74c_aca6_4dd2_8e59_1ec40723092c
name: DGKZ
is: SBO:0000252
is encoded by: hsa:8525
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: B7Z2M9

metaM acac x
name: acetoacetate
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00060
is: SBO:0000247
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR RE3243R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: RE3243
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_94a26495_d176_4f42_a1f1_e52019dd17f2
boundary condition: true
has only substance units: false
is encoded by: hsa:3635
initial concentration: NaN
type: Species
initial amount: NaN
name: INPP5D
is: Q92835
constant: false
is: SBO:0000252

metaM HC00250 c
constant: false
boundary condition: false
is: CHEBI:29919
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide

metaM 3mop m
is: CHEBI:28654
initial concentration: 1.0
is: HMDB00491
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 3-methyl-2-oxopentanoate
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false

metaR 5MTHFt2le
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
kinetic law: MODEL1310110032#
reversible: true
fast: false
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_293ff331_1d14_4fc1_8849_d8593fbe9c35
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS2
is: B7Z792
has only substance units: false
type: Species
is encoded by: hsa:4720
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_c0c054ee_4da5_4c4c_871a_48831752da92
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:83549
is: Q5JT09
name: UCK1
type: Species

metaM o2s m
is: HMDB02168
type: Species
initial concentration: 1.0
is: C00704
is: CHEBI:18421
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
name: Superoxide anion

http://identifiers.org/biomodels.db/MODEL1310110032#_bdd90321_b153_4c1c_b32a_4e4047a68309
is: P04745
constant: false
initial concentration: NaN
boundary condition: true
name: AMY1C
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:278
is: SBO:0000252

metaM ksi deg40 l
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 40
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false

metaM CE5162 r
name: trans,cis-2,9-octadecadienoyl-CoA
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110032#_e12eae39_6fb1_4834_89a1_d8a98e30a75d
name: ITPKB
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:3707
has only substance units: false
is: P27987
initial amount: NaN
boundary condition: true

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM sph1p e
initial concentration: 1.0
is: CHEBI:57939
has only substance units: false
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB01383

http://identifiers.org/biomodels.db/MODEL1310110032#_9f82a2b9_e8dc_470d_9209_64ee826e3935
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2747
name: GLUD2
is: P49448
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
is: HMDB02310
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57327
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
boundary condition: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR COAtm
is described by: ECO:0000269
reversible: true
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: CoA transporter
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is: SBO:0000185
type: Reaction
fast: false

metaR TYMSFt
is: SBO:0000185
name: Tyramine O-sulfate transport (diffusion)
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110032#

metaR Q10H2e
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
name: transport of ubiquinol into lymph
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

http://identifiers.org/biomodels.db/MODEL1310110032#_d6a8bc83_c622_4d5b_bbbf_ede9d1aae941
name: PLCB4
type: Species
initial amount: NaN
is encoded by: hsa:5332
boundary condition: true
has only substance units: false
is: E2QRH8
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f018ebba_e2c2_4a96_898b_a96baf145df6
has only substance units: false
type: Species
is: P17812
initial concentration: NaN
initial amount: NaN
name: CTPS1
is encoded by: hsa:1503
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_7e8637c9_cc3f_4a55_aa94_8fbde9fa4fb2
name: NDUFA11
boundary condition: true
has only substance units: false
is encoded by: hsa:126328
initial amount: NaN
constant: false
is: SBO:0000252
is: C9JT23
initial concentration: NaN
type: Species

metaR 3HCO3 NAt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
name: 3HCO3_NAt
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reversible: true
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110032#

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false
kinetic law: MODEL1310110032#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#

metaM oh1 c
type: Species
is: HMDB01039
name: hydroxide ion
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
is: SBO:0000247
has only substance units: false
is: C01328
constant: false
boundary condition: false
initial concentration: 1.0

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR ADEt
name: adenine reversible transport, cytosol
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD

metaM h2o2 c
type: Species
boundary condition: false
name: Hydrogen peroxide
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: C00027
initial amount: NaN
is: HMDB03125
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0556
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.14.19.1
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true

metaR RE3346C
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
fast: false
name: RE3346

http://identifiers.org/biomodels.db/MODEL1310110032#_49d94a77_6794_4a40_a555_d9ca45adc0f7
name: LDHB
is: P07195
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3945
type: Species

metaM lnlnca c
is: CHEBI:32387
has only substance units: false
type: Species
boundary condition: false
name: alpha-linolenate
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
is: HMDB01388
is: SBO:0000247

metaM pi n
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:43474
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: HMDB00973

metaR COAtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
name: coenzyme A transport, nuclear
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_c939a91c_ba5c_49ae_afa3_c9e3f4f2eab9
is: P09417
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5860
type: Species
name: QDPR
has only substance units: false
initial concentration: NaN

metaR GALASE3ly
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaR EX 34hpp
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM pchol hs r
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
is: SBO:0000247
name: Phosphatidylcholine
initial concentration: 1.0

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_c1461402_9d37_48f8_a885_c2e1b443b245
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: SDHA
initial amount: NaN
is encoded by: hsa:6389
initial concentration: NaN
has only substance units: false
is: P31040

http://identifiers.org/biomodels.db/MODEL1310110032#_47217238_bda1_4eef_b70e_0b15d6581a85
type: Species
has only substance units: false
name: DGKG
is encoded by: hsa:1608
is: P49619
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_08d57d3f_42fb_4dbc_aa40_32aebbbbdba5
type: Species
is: O00476
name: SLC17A3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10786
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaM cspg b e
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
type: Species
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
is: CHEBI:17568
is: C00106
initial concentration: 1.0
is: HMDB00300
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_c36453e6_8c6d_4ee7_b564_5e068f341ded
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:1345
is: P09669
boundary condition: true
initial concentration: NaN
name: COX6C
constant: false

metaR r1450
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: false
type: Reaction

metaR r0555
reactant: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12108679,PMID:14741190 NOTES:
name: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
fast: false

metaM sph1p c
is: CHEBI:57939
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01383
constant: false
type: Species
initial concentration: 1.0

metaM pnto R e
boundary condition: false
is: HMDB00210
name: (R)-Pantothenate
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
has only substance units: false
is: CHEBI:7916
type: Species

metaM dlnlcgcoa r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: C03595
has only substance units: false
type: Species
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false

metaM fprica c
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: SBO:0000247
constant: false
is: C04734
is: HMDB01439
initial concentration: 1.0
initial amount: NaN
type: Species
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
boundary condition: false
is: CHEBI:58467

metaR SPODMe
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110032#
name: superoxide dismutase, extracellular
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176

metaM pi m
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009

http://identifiers.org/biomodels.db/MODEL1310110032#_55593898_8794_465e_8011_8972dd10e93d
is: SBO:0000252
constant: false
is encoded by: hsa:27068
name: PPA2
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaM ppcoa x
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57392
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
has only substance units: false
is: C00100
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_e1dc4585_7511_4c71_af14_50a358fbc35d
initial amount: NaN
type: Species
is: P49189
is: SBO:0000252
is encoded by: hsa:223
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: ALDH9A1

http://identifiers.org/biomodels.db/MODEL1310110032#_9fcef587_65dd_482c_bfc9_4d18f657455e
boundary condition: true
is encoded by: hsa:6532
is: SBO:0000252
name: SLC6A4
initial concentration: NaN
initial amount: NaN
type: Species
is: P31645
constant: false
has only substance units: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR DHCR242r
name: 24-dehydrocholesterol reductase [Precursor]
is described by: ECO:0000134
product: MODEL1310110032#
reversible: false
is: SBO:0000176
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_d36b296f_8ea0_47ee_b586_a255c0f255e9
boundary condition: true
is: Q9Y4K0
initial concentration: NaN
constant: false
is encoded by: hsa:4017
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: LOXL2

metaR r2108
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM pi l
is: CHEBI:43474
boundary condition: false
is: SBO:0000247
type: Species
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
initial concentration: 1.0
is: HMDB00973
constant: false
has only substance units: false

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
name: coenzyme A transport, peroxisomal
reactant: MODEL1310110032#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_947a4fe9_8a8c_4eb4_bcd4_664d1489e9a6
is encoded by: hsa:7296
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: TXNRD1
constant: false
type: Species

metaM pchol hs m
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16110
type: Species
initial concentration: 1.0
initial amount: NaN
name: Phosphatidylcholine
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaR r0321
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110032#

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

metaM acgal c
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: N-acetyl-D-galactosamine
initial amount: NaN
is: HMDB00212
type: Species
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: SBO:0000247

metaM asp D c
is: HMDB06483
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: D-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110032#_ac23c145_f6aa_4ec5_a265_88f53dbc8b9a
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACSL4
initial amount: NaN
is encoded by: hsa:2182
boundary condition: true
has only substance units: false
is: O60488
type: Species

metaM lcts e
has only substance units: false
is: CHEBI:17716
type: Species
is: HMDB00186
boundary condition: false
constant: false
initial concentration: 1.0
name: Lactose
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: C00243

http://identifiers.org/biomodels.db/MODEL1310110032#_51cb7d3c_13c7_4044_af32_6358e03b2359
initial amount: NaN
is encoded by: hsa:5092
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PCBD1
is: SBO:0000252
is: P61457
constant: false

metaM dtmp e
is: HMDB01227
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
has only substance units: false
name: dTMP(2-)
boundary condition: false
is: CHEBI:26999
constant: false

metaM trdox m
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:18191
type: Species
name: Oxidized thioredoxin
is: SBO:0000247

metaM acnacngalgbside hs g
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
is: HMDB00223
is: CHEBI:3338
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: disialyl galactosylgloboside
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM acgam1p c
name: N-Acetyl-D-glucosamine 1-phosphate
is: SBO:0000247
is: CHEBI:7125
constant: false
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
type: Species
has only substance units: false
boundary condition: false
is: HMDB01367
initial amount: NaN

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_1e7a1f1d_6e3d_46ec_91ca_b39a4a06a5cb
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:220
is: P47895
initial amount: NaN
name: ALDH1A3
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_e820c3a4_6015_4536_9a64_fb7794e38ce7
type: Species
is: SBO:0000252
boundary condition: true
name: SLC7A8
constant: false
initial amount: NaN
is: Q9UHI5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23428

metaR r2107
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_4e9b82db_1d0d_4d5b_a89e_4eee43e64223
is: SBO:0000252
boundary condition: true
name: _H17063_1_c
has only substance units: false
is encoded by: hsa:H17063
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_bc14232b_7631_4d63_aee2_bc8cce257145
has only substance units: false
type: Species
is encoded by: hsa:4830
initial concentration: NaN
name: NME1:NME2
constant: false
is: SBO:0000297
boundary condition: true
initial amount: NaN

metaM 2mpdhl m
type: Species
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
boundary condition: false
is: CHEBI:17577
constant: false
is: SBO:0000247
initial concentration: 1.0
name: S-(2-Methylpropanoyl)-dihydrolipoamide
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_375f6b29_54cf_4ad3_af12_71da1bf5cc44
name: RPE
initial amount: NaN
is encoded by: hsa:6120
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q53TV9
initial concentration: NaN

metaM apoC Lys btn c
notes: FORMULA: C16H27N4O3SX CHARGE: 0
type: Species
boundary condition: false
is: CHEBI:32551
constant: false
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
is: SBO:0000247
is: HMDB00182
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2b9751ad_9218_43a8_9308_09d813cad278
is encoded by: hsa:4668
name: NAGA
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: P17050
constant: false
initial concentration: NaN

metaR LEUKTRA4t
fast: false
name: leukotriene A4 transport
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110032#

metaM anth c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16567
has only substance units: false
initial amount: NaN
boundary condition: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
type: Species
constant: false

metaR PAIL4P HStn
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reversible: true
type: Reaction

metaM orn c
boundary condition: false
initial amount: NaN
name: Ornithine
is: HMDB00214
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110032#_9a33fdf2_ff70_4f02_8fda_c2a02c0f187f
is: SBO:0000252
is encoded by: hsa:6817
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: SULT1A1
has only substance units: false

metaR r2199
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000185

metaR COAtr
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110032#

metaR MANtly
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
is: SBO:0000185
name: mannose efflux from lysosome
fast: false
reversible: false
is described by: ECO:0000000

metaM xol7a r
is: CHEBI:1296
constant: false
initial amount: NaN
name: 20-hydroxycholesterol
type: Species
initial concentration: 1.0
is: HMDB01496
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
has only substance units: false
boundary condition: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM asp D e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB06483
name: D-aspartate(1-)
constant: false
has only substance units: false
is: CHEBI:29990
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_48220e0c_fa08_40de_8a05_0aa229a7755e
constant: false
type: Species
name: IMPA1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B7Z6Q4
boundary condition: true
is encoded by: hsa:3612
has only substance units: false

metaM adrn e
name: adrenic acid
is: HMDB02226
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:53487

metaM HC00319 m
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:30794
name: Malonate
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR ILETAm
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase, mitochondrial
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3a3573c0_63d3_48e7_a03b_8bc0a7e18ac6
name: PECR
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55825
constant: false
type: Species
is: Q9BY49
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_9c3e81fe_8c4d_4049_a1cb_733b9b185632
initial amount: NaN
boundary condition: true
is: Q8TDB8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:144195
constant: false
name: SLC2A14
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ba588af5_6234_4c60_8a8d_8573e7fb2b1d
boundary condition: true
constant: false
is: O95470
is encoded by: hsa:8879
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SGPL1

http://identifiers.org/biomodels.db/MODEL1310110032#_a7f35745_4cea_4cec_a744_a8f6b399269f
type: Species
name: NDUFA5
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q16718
is: SBO:0000252
is encoded by: hsa:4698
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d24243a8_7538_4355_9306_b4d6956f58ee
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: E9PAX2
constant: false
is encoded by: hsa:57818
type: Species
name: G6PC2
has only substance units: false
initial amount: NaN

metaR r2109
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110032#
fast: false
is described by: ECO:0000000

metaR ASPDTDe
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
reversible: true
fast: false
name: D-aspartate transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110032#_0baa7dd3_60bb_4b1e_88a1_4c993981ecbc
type: Species
name: XDH
is: P47989
is encoded by: hsa:7498
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM nicrnt c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Nicotinate D-ribonucleotide
type: Species
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
has only substance units: false
is: CHEBI:57502
constant: false
is: C01185
is: HMDB01132

metaM CE2422 m
has only substance units: false
constant: false
type: Species
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
boundary condition: false
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR ARSA
kinetic law: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.8
reversible: false
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
reactant: MODEL1310110032#
is described by: ECO:0000000
name: Arylsulfatase A
modifier: MODEL1310110032#
fast: false

metaR r0559
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
product: MODEL1310110032#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true

metaR CMPACNAtg
name: CMP-Sia Golgi transport via CMP antiport
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_282e641f_f10b_4083_94bb_627439310df9
constant: false
name: FOLR1
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2348

metaM galacglcgalgluside hs g
name: Lc4Cer
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:17103
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_2982ae1c_a5df_4f38_8a2f_0794cdd281d3
boundary condition: true
name: TYMP
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1890
type: Species
is: SBO:0000252
is: P19971

metaM ficytC m
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
has only substance units: false
name: Ferricytochrome c
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:15991

metaM glc D e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial amount: NaN
initial concentration: 1.0
is: CHEBI:4167
type: Species
is: HMDB00122
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

metaR DADAe
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
name: Deoxyadenosine deaminase, extracellular
is version of: http://identifiers.org/ec-code/3.5.4.4
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7e102eda_a3b1_48cf_960f_bbb0157bf110
boundary condition: true
initial concentration: NaN
is: B3KTQ4
is: SBO:0000252
is encoded by: hsa:8706
has only substance units: false
name: B3GALNT1
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_1c5551e7_2a17_45ac_8883_c77252d84882
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA278423
has only substance units: false
initial concentration: NaN
name: _AA278423_1_m
initial amount: NaN

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110032#
fast: false
is described by: ECO:0000000
product: MODEL1310110032#

metaM n2m2nm l
has only substance units: false
initial amount: NaN
is: HMDB01356
type: Species
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: CHEBI:57312
is: SBO:0000247
constant: false
name: n2m2nmasn (w/o peptide linkage)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_719d05cf_5740_4ca2_8f64_0bba8875388e
is encoded by: hsa:1375
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: CPT1B
is: SBO:0000252
initial amount: NaN
is: Q53FV7

http://identifiers.org/biomodels.db/MODEL1310110032#_c5ef3dd5_79af_42ab_968e_e7c02fa2cc24
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:9563
initial amount: NaN
is: O95479
name: H6PD
type: Species

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
is: CHEBI:58335
initial amount: NaN
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaR CYTDt
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110032#
reversible: true
fast: false
name: cytidine facilated transport in cytosol

http://identifiers.org/biomodels.db/MODEL1310110032#_c8e2fae6_d029_4c0a_be43_9adfec8c183c
name: MYO5B
is: Q9H6Y6
is encoded by: hsa:4645
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r2197
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

metaM 34dhphe e
initial amount: NaN
constant: false
name: L-dopa
is: SBO:0000247
is: CHEBI:15765
type: Species
is: HMDB00181
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_88b349d6_9c92_4534_b8d6_4ad020a7a431
has only substance units: false
is: SBO:0000252
name: NME1
initial concentration: NaN
constant: false
is encoded by: hsa:4830
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_5b4d81d8_050e_4143_bd78_4aeb751ff4d9
constant: false
is encoded by: hsa:79695
is: Q8IXK2
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: GALNT12

http://identifiers.org/biomodels.db/MODEL1310110032#_1423532a_2d95_4c78_b09d_086d2a99be37
constant: false
is encoded by: hsa:389015
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6AI14
has only substance units: false
name: SLC9A4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_807c9034_8dc4_427e_81a8_bf4b744e79fd
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: Q92911
name: SLC5A5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6528
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_3ac1df2d_4709_43ee_919b_68484a417c7a
is: SBO:0000252
type: Species
initial amount: NaN
name: IDH2
has only substance units: false
boundary condition: true
is: P48735
initial concentration: NaN
is encoded by: hsa:3418
constant: false

metaM pi x
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate
has only substance units: false
is: HMDB00973
constant: false
is: SBO:0000247

metaR RE2660C
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
name: RE2660
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
fast: false

metaM q10h2 m
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB13111
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
name: Ubiquinol-10
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3c585b00_8c3f_479d_8009_8bd15af3639b
name: MTHFD2
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10797
is: P13995
is: SBO:0000252
initial amount: NaN
type: Species

metaM nadph c
is: CHEBI:57783
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
is: C00005
is: HMDB00221
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_fb2c1e67_9aea_44f5_b981_ce8d454b8c4b
constant: false
initial amount: NaN
has only substance units: false
name: AK4
is encoded by: hsa:205
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR r2103
is: SBO:0000185
modifier: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110032#
type: Reaction
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM 3mop e
is: HMDB00491
type: Species
is: CHEBI:28654
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial amount: NaN
constant: false
name: 3-methyl-2-oxopentanoate

metaR r2198
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM retn r
constant: false
name: all-trans-retinoate
is: CHEBI:35291
is: HMDB01852
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
type: Species
boundary condition: false

metaR ATP2ter
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
fast: false
product: MODEL1310110032#

metaM glc D c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00122
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
has only substance units: false
name: D-glucose
is: SBO:0000247

metaM acgal1p c
initial concentration: 1.0
constant: false
type: Species
name: N-Acetyl-D-galactosamine 1-phosphate
is: CHEBI:55404
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB06480
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: SBO:0000247

metaM HC02175 e
is: CHEBI:27689
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
type: Species
boundary condition: false
name: caprate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM acnacngalgbside hs c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: disialyl galactosylgloboside
constant: false
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338
boundary condition: false
is: C00036
type: Species
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110032#_c7b0a753_bc91_45b3_8824_77d2f8b27e68
boundary condition: true
is encoded by: hsa:8802
has part: Q96I99
name: SUCLG2:SUCLG1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000297
has part: P53597
initial amount: NaN
is encoded by: hsa:8801
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1f3c7b4f_81b6_49b1_a228_bf576807e69e
initial amount: NaN
constant: false
is: Q16718
is encoded by: hsa:4698
has only substance units: false
is: SBO:0000252
name: NDUFA5
type: Species
boundary condition: true
initial concentration: NaN

metaM Rtotal3 e
type: Species
is: CHEBI:3554
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: C00255
is: HMDB00244
has only substance units: false
boundary condition: false
constant: false
name: R total 3 position

http://identifiers.org/biomodels.db/MODEL1310110032#_f74d32dc_db05_41e2_a472_0e4d47944093
initial amount: NaN
type: Species
is encoded by: hsa:8526
name: DGKE
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: A1L4Q0

metaR HOXG
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
type: Reaction
name: Heme oxygenase 1
kinetic law: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.14.99.3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme

metaM apoC Lys m
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
is: HMDB00182
is: SBO:0000247
initial amount: NaN
name: Apocarboxylase (Lys residue)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:32551

metaR r1459
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
name: Transport reaction
reversible: true

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR r2106
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#

metaM dtmp c
initial concentration: 1.0
name: dTMP
type: Species
has only substance units: false
is: C00364
is: HMDB01227
is: CHEBI:26999
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaR r2195
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false

metaM 34dhphe c
is: SBO:0000247
name: L-dopa
boundary condition: false
initial amount: NaN
is: CHEBI:15765
is: HMDB00181
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
type: Species

W3 CDTF: Wed Aug 29 22:49:26 BST 2012

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction

metaM h2o g
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial concentration: 1.0
name: water
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
type: Species

metaR GLNS
fast: false
name: glutamine synthetase
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.1.1.15
is described by: ECO:0000254
modifier: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f24987cc_be5a_4528_920b_83fc64486186
type: Species
boundary condition: true
is: Q9Y2C5
has only substance units: false
is encoded by: hsa:10050
is: SBO:0000252
initial concentration: NaN
name: SLC17A4
initial amount: NaN
constant: false

metaR DHFtm
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: dihydrofolate reversible mitochondrial transport
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_c4f78c10_8bcb_4b57_926a_a7f6095dfdb5
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: ACAA1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_4a62a0c4_e59f_4d34_8a4f_6491f49f15eb
name: VNN3
initial amount: NaN
constant: false
is encoded by: hsa:55350
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR COAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
name: CoA transport in Golgi via diffusion
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_466d76dc_70ec_43af_9a76_975c69f8b813
initial concentration: NaN
has only substance units: false
name: FTCD
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:10841

metaR r0899
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
kinetic law: MODEL1310110032#
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01123
initial amount: NaN
name: anthranilate

metaM 3mop c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
constant: false
has only substance units: false
type: Species
is: CHEBI:28654
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate

metaM ump r
constant: false
is: CHEBI:57865
name: UMP
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
initial concentration: 1.0
is: HMDB00288
has only substance units: false
boundary condition: false
type: Species

metaR ASNtm
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: false
name: L-asparagine transport, mitochondrial

metaR FTCD
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
product: MODEL1310110032#
name: formimidoyltransferase cyclodeaminase
is version of: http://identifiers.org/ec-code/2.1.2.5
kinetic law: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000134

metaR ASNNm
is described by: ECO:0000254
modifier: MODEL1310110032#
type: Reaction
name: L-asparaginase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.1
reactant: MODEL1310110032#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

http://identifiers.org/biomodels.db/MODEL1310110032#_cdcf79c3_83bd_4c9d_a897_ee4b9ca7162a
boundary condition: true
is: P15121
has only substance units: false
name: AKR1B1
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:231
constant: false

metaR r2105
is described by: ECO:0000000
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_128e1b91_1cda_4b25_812e_5bf1328d9de9
is: Q99643
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:6391
boundary condition: true
initial concentration: NaN
name: SDHC

http://identifiers.org/biomodels.db/MODEL1310110032#_c644779c_f27c_47ee_85b6_320a1ceca2b7
has only substance units: false
name: DGKH
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:160851
constant: false
is: A8K0I1

http://identifiers.org/biomodels.db/MODEL1310110032#_761be1b9_b253_4e42_9f30_9d83ddbc94e0
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC26A4
constant: false
type: Species
is: SBO:0000252
is: O43511
is encoded by: hsa:5172

metaM lnlnca l
is: HMDB01388
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: alpha-linolenate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387

metaM HC02175 c
is: SBO:0000247
is: CHEBI:27689
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: caprate
initial concentration: 1.0

metaR r2196
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110032#
is described by: ECO:0000000

metaM acnacngalgbside hs e
constant: false
initial concentration: 1.0
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: C00036
name: disialyl galactosylgloboside
has only substance units: false
boundary condition: false
type: Species
is: HMDB00223
is: SBO:0000247
initial amount: NaN

metaR DADA
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: Deoxyadenosine deaminase
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
product: MODEL1310110032#

metaM arachdcrn r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: C20:4 carnitine
constant: false
type: Species
is: HMDB06523
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57368
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

W3 CDTF: Wed Aug 29 22:49:26 BST 2012

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR DCSPTN1CRNt
reversible: false
name: transport into the mitochondria (carnitine)
fast: false
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110032#

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB02022
is: C03838
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial concentration: 1.0

metaM HC01522 c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: Gentisate aldehyde
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

http://identifiers.org/biomodels.db/MODEL1310110032#_a00d2908_34e6_4048_9eab_6b8382692a4f
name: ALDH2
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:217
initial amount: NaN
is: P05091

metaM lnlnca e
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
has only substance units: false
name: alpha-linolenate
type: Species
is: CHEBI:32387
is: SBO:0000247
is: HMDB01388

http://identifiers.org/biomodels.db/MODEL1310110032#_e6e08efe_b771_4308_a6b5_9665b035e256
name: NAE1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8883
boundary condition: true
constant: false
initial amount: NaN
is: A8MU28
has only substance units: false

metaR CYSTS
type: Reaction
name: cystathionine beta-synthase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.22
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#

metaM acgal l
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
name: N-acetyl-D-galactosamine
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28037
type: Species
initial concentration: 1.0

metaM h2o2 e
initial concentration: 1.0
name: hydrogen peroxide
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16240
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_6bc5de7c_5b4d_4e78_acfa_ea8cbcb5162c
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: _LOC374569_1_e
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:LOC374569

metaR r2193
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e4e66e39_bf19_4ca1_a9b2_27ac911683de
name: PYCR1
is encoded by: hsa:5831
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: A6NFM2
boundary condition: true
type: Species

metaM h2o e
constant: false
initial concentration: 1.0
is: C00001
is: CHEBI:15377
is: HMDB02111
boundary condition: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
type: Species
is: SBO:0000247
initial amount: NaN

metaM glyald c
is: CHEBI:17378
boundary condition: false
type: Species
initial concentration: 1.0
is: C00577
is: HMDB01051
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaM ser L m
is: HMDB00187
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
name: L-serine
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:17115

metaR r2100
is described by: ECO:0000000
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is: SBO:0000185

W3 CDTF: Wed Aug 29 22:49:26 BST 2012

metaR r0474
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
is described by: ECO:0000000

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f337005a_d95d_4a50_af66_6871c681356b
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4830
name: NME1
initial concentration: NaN
is: P15531
is: SBO:0000252

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR IDOURtly
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
modifier: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
name: iduronate transport into lysososme
product: MODEL1310110032#

metaM hdca r
name: Hexadecanoate (n-C16:0)
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:7896
is: HMDB00220
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: C00249

http://identifiers.org/biomodels.db/MODEL1310110032#_1700e3b3_d2f0_4a1c_8a52_8b791f76fb3d
initial amount: NaN
is: P27144
boundary condition: true
is encoded by: hsa:205
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: AK4

metaR UMPK6n
kinetic law: MODEL1310110032#
name: UMP kinase (dCTP),nuclear
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110032#

metaR r0475
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaR RTOTAL2FATPc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9882158a_9c14_4bd5_b6c9_1c3ba46a2ee5
constant: false
boundary condition: true
has only substance units: false
is: Q7GXZ1
is encoded by: hsa:4541
initial concentration: NaN
name: ND6
is: SBO:0000252
type: Species
initial amount: NaN

metaR 3HBCOAHLm
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
reversible: false
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110032#_cd72f42a_3cec_4915_91f2_e47e1f35e356
boundary condition: true
type: Species
initial amount: NaN
name: PKM2
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5315
initial concentration: NaN
is: P14618

metaR LPS2e
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110032#
name: lipase, extracellular
fast: false
reactant: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ

W3 CDTF: Wed Aug 29 22:49:26 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110032#_86bf978f_94b5_41cd_a50c_be2e62892b11
name: RHAG
is: SBO:0000252
is: Q96E98
is encoded by: hsa:6005
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_df10f4b5_4e4a_460c_8c94_a4ff64ade6d7
initial amount: NaN
constant: false
is encoded by: hsa:2752
name: GLUL
is: SBO:0000252
type: Species
is: P15104
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_66efad39_2bfa_4a74_8462_a8bb2dcc5f39
is: Q02318
type: Species
boundary condition: true
is encoded by: hsa:1593
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CYP27A1
initial amount: NaN

metaR NDPK10
kinetic law: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000134

metaM amp x
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: CHEBI:456215
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB00045
name: AMP
initial concentration: 1.0
boundary condition: false
is: C00020

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
has only substance units: false
is: CHEBI:16987
type: Species
is: HMDB12130

metaR RE0935E
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
name: RE0935
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
reactant: MODEL1310110032#

metaR PIter
fast: false
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
name: phosphate transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000212
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

metaR OCTAt
product: MODEL1310110032#
reversible: true
fast: false
is: SBO:0000185
name: Octanoate transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_64951519_f66f_4737_94e5_35a1e676b1d5
type: Species
is: Q96I99
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8801
constant: false
initial amount: NaN
boundary condition: true
name: SUCLG2

metaM arachdcrn m
has only substance units: false
name: C20:4 carnitine
initial amount: NaN
type: Species
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3c0ec3a2_7275_4e10_945d_c75c102ba447
name: DCK
has only substance units: false
initial amount: NaN
boundary condition: true
is: P27707
is encoded by: hsa:1633
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM h2o c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: C00001
notes: FORMULA: H2O CHARGE: 0
boundary condition: false
is: HMDB02111
name: H2O
is: CHEBI:3303
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_b89fb2bb_b246_4eef_870e_a5cccf9b023c
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: GCK
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2645

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
is: CHEBI:43474
boundary condition: false
type: Species
initial concentration: 1.0
is: C00009
is: HMDB00973
name: hydrogenphosphate
initial amount: NaN
has only substance units: false

metaR r2102
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_99032d78_7f18_497d_ab13_915aae1692e9
name: GPX7
type: Species
is: Q96SL4
is encoded by: hsa:2882
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_30413823_d1c9_4b33_a208_cadf8a89426f
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ELOVL4
initial amount: NaN
is encoded by: hsa:6785
is: SBO:0000252
is: Q9GZR5
type: Species

metaR CYTK8n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110032#
is: SBO:0000176
name: cytidylate kinase (CMP,dATP),nuclear
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9119bee4_37e3_471c_af94_1c6bba481bc0
initial amount: NaN
name: ACSL4
is encoded by: hsa:2182
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q5JWV8

metaM glutcoa m
name: glutaryl-CoA(5-)
boundary condition: false
is: CHEBI:57378
has only substance units: false
is: HMDB01339
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN
initial concentration: 1.0

metaR GLCt1r
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110032#
type: Reaction
name: glucose transport (uniport)
reversible: true

metaR FERO
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: ferroxidase
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0cf2da24_639f_4c27_90e2_f5c21fa5e54d
has only substance units: false
is: P50225
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6817
name: SULT1A1
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM Rtotal3 c
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16189
has only substance units: false
initial amount: NaN
name: R total 3 position
is: HMDB01448

metaR RE3381E
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
name: RE3381
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

metaM HC00319 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30794
type: Species
name: Malonate
constant: false
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_bd585c19_8001_4111_93d7_afd8a054d4ab
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q16851
is encoded by: hsa:7360
type: Species
name: UGP2

http://identifiers.org/biomodels.db/MODEL1310110032#_73a6a745_f709_4ba0_96a7_9b218d344c5f
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PC
constant: false
type: Species
is encoded by: hsa:5091

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR ETF
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
reversible: false
name: electron transfer flavoprotein
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571

metaR NDPK8n
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000304
fast: false

metaM HC00250 e
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
name: hydrosulfide
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:29919

metaR r2101
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110032#
reversible: true
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#

metaM 3aib D m
is: SBO:0000247
is: HMDB02299
type: Species
name: D-3-Amino-isobutanoate
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

metaR r1010
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
is: SBO:0000185
is described by: ECO:0000000

metaM core6 l
constant: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaR r2321
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_d668ba8e_52dd_4aad_ba6a_a8aadca33508
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:50
name: ACO2
constant: false
is: SBO:0000252
is: Q99798
has only substance units: false

metaR APOCFm
reversible: false
type: Reaction
reactant: MODEL1310110032#
name: Apocarboxylase formation, mitochondrial
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176

metaR HMGLx
kinetic law: MODEL1310110032#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is described by: ECO:0000134
product: MODEL1310110032#
modifier: MODEL1310110032#
name: hydroxymethylglutaryl-CoA lyase

metaM ile L m
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
name: L-isoleucine
is: HMDB00172

http://identifiers.org/biomodels.db/MODEL1310110032#_66f05552_6e65_4f64_aaad_511ca696644b
boundary condition: true
initial amount: NaN
name: INPP5J
is: SBO:0000252
constant: false
is encoded by: hsa:27124
has only substance units: false
initial concentration: NaN
is: Q15735
type: Species

metaM lnlnca r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387
initial concentration: 1.0
is: HMDB01388
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: alpha-linolenate
has only substance units: false
type: Species

metaM itp n
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00189
is: CHEBI:57614
initial amount: NaN
initial concentration: 1.0
name: ITP(3-)
constant: false

metaR PPD2CSPp
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
fast: false
is: SBO:0000176
name: PPD2CSPp
type: Reaction
product: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_a7fdfa00_ab3d_4e78_aad6_29f04906fdb6
type: Species
is: SBO:0000252
is encoded by: hsa:4512
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: COX1
is: Q7GXY8

http://identifiers.org/biomodels.db/MODEL1310110032#_fb645260_bde0_45a0_9d18_9971fbd33792
constant: false
is encoded by: hsa:1109
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P17516
has only substance units: false
initial concentration: NaN
name: AKR1C4

metaR r1625
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#

metaR UDPtl
reversible: true
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reactant: MODEL1310110032#
is: SBO:0000185
name: udp intracellular transport
product: MODEL1310110032#
type: Reaction

metaM ru5p D c
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
boundary condition: false
is: CHEBI:58121
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EHGLAT2m
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110032#
is described by: ECO:0000304
product: MODEL1310110032#
reactant: MODEL1310110032#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_dd2c92ca_e07a_4d93_89f8_c674b2d1516c
is encoded by: hsa:4513
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:9167
has part: Q53XN1
is encoded by: hsa:1345
is encoded by: hsa:1329
is encoded by: hsa:1350
is encoded by: hsa:1347
is encoded by: hsa:84701
is encoded by: hsa:170712
constant: false
has part: Q6FGA0
initial amount: NaN
has part: P09669
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1339
has part: Q6YFQ2
is encoded by: hsa:125965
is encoded by: hsa:1327
has part: P24310
is encoded by: hsa:1349
has part: Q7GXZ8
is encoded by: hsa:1337
has part: P13073
is encoded by: hsa:4512
has part: P14854
is encoded by: hsa:9377
has part: P12074
has part: Q7Z4L0
is encoded by: hsa:1340
is encoded by: hsa:4514
is: SBO:0000297
is encoded by: hsa:1346
has part: P15954
has part: P20674
has part: P24311
has part: H0UI06
has part: Q96KJ9
has part: Q7GXY8
has part: P00414
is encoded by: hsa:1351
has part: Q53YB7
is encoded by: hsa:341947
has part: Q02221
has part: Q8TF08

http://identifiers.org/biomodels.db/MODEL1310110032#_40aac004_3eef_4890_ba04_f0e7c17d29ca
constant: false
name: LTA4H
is encoded by: hsa:4048
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: P09960
is: SBO:0000252
initial amount: NaN

metaR r2322
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false

metaM HC02214 c
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin-f1alpha
is: CHEBI:28852
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM HC01415 m
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
has only substance units: false
type: Species
boundary condition: false
name: (2E)-Octenoyl-CoA
is: CHEBI:27537
initial concentration: 1.0
initial amount: NaN
constant: false

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
reversible: true
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110032#
name: RE1533
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR r0892
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000

metaR DDPGAm
reactant: MODEL1310110032#
type: Reaction
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_e02f6b84_679f_4c05_b6b2_33f998bca2fb
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6548
type: Species
is: P19634
constant: false
name: SLC9A1
initial concentration: NaN
has only substance units: false

metaR ME1m
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
name: malic enzyme (NAD), mitochondrial
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_387e8fea_2535_4dd1_aac4_778c48035f67
has only substance units: false
boundary condition: true
is: Q9H936
is encoded by: hsa:79751
constant: false
initial amount: NaN
name: SLC25A22
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r1624
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ea5b2d27_e488_4c75_a669_936ca602cdce
is: P16885
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5336
boundary condition: true
initial amount: NaN
name: PLCG2
type: Species
has only substance units: false
constant: false

metaR DURAD2
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
name: dihydrothymin dehydrogenase (NADP)
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110032#

metaR FAOXC160
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
modifier: MODEL1310110032#
type: Reaction
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM digalsgalside hs c
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/8384
name: Digalactosylceramidesulfate
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: C06127

metaR UDPGALtg
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-Gal Golgi transport via CMP antiport
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e3d4efac_3b4f_4d2c_aa2d_fa3cd63ba73d
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC12A6
is: Q9UHW9
is encoded by: hsa:9990
boundary condition: true
constant: false

metaR SARCStm
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
fast: false
name: Sarcosine transport (mitochondrial)
reversible: false

metaM g3p c
has only substance units: false
is: C00661
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
type: Species
is: HMDB01112
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
initial amount: NaN
name: Glyceraldehyde 3-phosphate
is: CHEBI:58027

metaR DGCHOLtx
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
name: bile acid intracellular transport
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7af29754_1b34_49ba_a7c2_8c95edce8820
name: PPA2
constant: false
type: Species
is: F8WDN9
is encoded by: hsa:27068
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM mag hs e
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:32391
boundary condition: false
type: Species
name: monoacylglycerol 2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB03073
initial amount: NaN
constant: false

metaM n2m2mn l
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C42H71N3O31 CHARGE: 0
constant: false
is: HMDB00939
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
is: CHEBI:16680
initial concentration: 1.0

metaM pail hs c
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_0aa1211c_f8ff_429f_8cc4_c5374705203a
has only substance units: false
constant: false
is: P49247
name: RPIA
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:22934
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_beb79e8d_0a45_4c7c_8d38_09263f169768
initial amount: NaN
type: Species
is encoded by: hsa:51703
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q9ULC5
name: ACSL5

metaR r0812
is described by: ECO:0000000
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110032#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:

metaR r1599
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction

metaR r2323
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_b677d5c4_3216_451c_bd31_04d9ba3b0d54
is: D3DX95
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
type: Species
initial concentration: NaN
is: SBO:0000252
name: CHAT

metaR 4NPHSFte
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: xenobiotic transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
product: MODEL1310110032#
reversible: true
is: SBO:0000185

metaR r1627
type: Reaction
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_c2a49303_076b_4f32_87db_de68ad9fc87c
is: SBO:0000252
name: HEXB
boundary condition: true
type: Species
is: P07686
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3074

metaR r2110
modifier: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110032#

metaR BAMPPALDOX
type: Reaction
is: SBO:0000176
is described by: ECO:0000212
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_1efb2a2c_9e33_4dc4_a63a_44c66dcb7f27
is encoded by: hsa:56848
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q9NRA0
initial concentration: NaN
has only substance units: false
constant: false
name: SPHK2

http://identifiers.org/biomodels.db/MODEL1310110032#_d11f9315_ddb8_4c86_bbfb_aa487953355e
name: AGXT2
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:64902
initial amount: NaN
is: SBO:0000252
is: Q9BYV1

http://identifiers.org/biomodels.db/MODEL1310110032#_a40dba8e_a831_4061_ac1c_bed96c5f7cc3
initial amount: NaN
is encoded by: hsa:29920
constant: false
type: Species
is: SBO:0000252
name: PYCR2
has only substance units: false
is: Q96C36
boundary condition: true
initial concentration: NaN

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is described by: ECO:0000269
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176

metaR 5HTRPVESSEC
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: 5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven)
type: Reaction
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of 5htrp from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
reversible: false
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110032#_8220272c_010b_41e4_ace8_541d7d04e26e
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AA278423
initial amount: NaN
name: _AA278423_1_c

metaR r1626
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM pchol hs c
boundary condition: false
is: SBO:0000247
notes: FORMULA: CHARGE: 0
is: CHEBI:21338
initial amount: NaN
constant: false
initial concentration: 1.0
name: pchol_hs[c]
is: HMDB02704
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_f5a08e32_d3d0_4ea0_bb2f_4168698fce0e
has only substance units: false
boundary condition: true
is encoded by: hsa:5315
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: PKM2

metaM h c
initial amount: NaN
name: proton
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110032#_7c9e3e1a_8698_4d8f_8bdc_80a15f3da6b9
name: SLCO1C1
type: Species
initial amount: NaN
is: Q5JPA4
has only substance units: false
constant: false
is encoded by: hsa:53919
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM ppcoa m
has only substance units: false
is: HMDB01275
is: CHEBI:57392
initial concentration: 1.0
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
boundary condition: false
name: Propanoyl-CoA
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_98cc2d1f_8059_4451_bc78_cf3e44b76df1
constant: false
type: Species
name: ALAS1
boundary condition: true
initial amount: NaN
is encoded by: hsa:211
is: P13196
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM fmn c
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01520
has only substance units: false
is: CHEBI:58210
type: Species
name: FMN
is: C00061

metaR r2324
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_b18e896e_2786_4a15_870b_584081440ac1
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PRPS1
is encoded by: hsa:5631
is: P60891
constant: false
is: SBO:0000252

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM lnlncg c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
name: gamma-linolenate
type: Species
has only substance units: false
is: CHEBI:32391
boundary condition: false
constant: false
initial amount: NaN

metaM h2o2 m
is: HMDB03125
is: C00027
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: CHEBI:16240
type: Species
name: Hydrogen peroxide
constant: false
initial amount: NaN

metaR LNLCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110032#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
is described by: ECO:0000000
name: carnitine transferase
fast: false
kinetic law: MODEL1310110032#

metaM xan x
constant: false
is: SBO:0000247
is: C00385
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false
has only substance units: false
name: Xanthine
is: HMDB00292
is: CHEBI:17712
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_117daf77_efbc_40fd_a115_b4e92b5b878a
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2686
constant: false
is: A0PJJ9
has only substance units: false
is: SBO:0000252
name: GGT7
boundary condition: true

metaM retinol c
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00305
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
is: SBO:0000247
boundary condition: false
name: retinol
is: CHEBI:50211

metaM retn e
constant: false
is: HMDB01852
initial concentration: 1.0
is: CHEBI:35291
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
name: all-trans-retinoate
type: Species
is: SBO:0000247
initial amount: NaN

metaR GALt4
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
name: galactose transport via sodium symport
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110032#

metaR RE0453N
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
reversible: true
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false

metaR r1621
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_4199c096_112e_4eca_a02d_d101251d3425
type: Species
boundary condition: true
is encoded by: hsa:AI761708
has only substance units: false
name: _AI761708_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1850
name: Y+LAT2 Utilized transport
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NH4tn
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
name: ammonia nuclear transport
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110032#_b44e93f5_91fd_43ef_bc00_0c7d7f21bf20
initial amount: NaN
is: P35575
is: SBO:0000252
constant: false
is encoded by: hsa:2538
name: G6PC
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaR NODe
reversible: true
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110032#
is: SBO:0000185
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110032#_d0948d33_a4ff_4718_adfb_236c42b4fce1
boundary condition: true
is: P22352
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2878
name: GPX3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM imp c
initial amount: NaN
name: IMP
is: CHEBI:58053
is: HMDB00175
constant: false
is: C00130
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
boundary condition: false

metaM HC02203 c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2
is: CHEBI:27820

metaM 12ppd R c
boundary condition: false
is: CHEBI:28972
has only substance units: false
is: HMDB01881
initial amount: NaN
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
type: Species
initial concentration: 1.0
name: (R)-propane-1,2-diol
is: SBO:0000247

metaM retinol e
initial concentration: 1.0
is: HMDB00305
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
type: Species

metaM trdrd c
is: SBO:0000247
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:15967
name: Reduced thioredoxin
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_07d111ce_a72a_4da7_b449_f4f2c04500ab
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q15181
constant: false
is encoded by: hsa:5464
boundary condition: true
initial concentration: NaN
name: PPA1

http://identifiers.org/biomodels.db/MODEL1310110032#_0e6b829b_2ab0_48e9_b0c0_88f88bc7a832
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51196
is: Q9P212
is: SBO:0000252
type: Species
initial amount: NaN
name: PLCE1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_0ef31e8f_efbb_4e5b_81e1_c034516c0283
is encoded by: hsa:8527
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: DGKD
is: Q16760
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR DCSPTN1t
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
is: SBO:0000185

metaM digalsgalside hs g
is: http://identifiers.org/pubchem.compound/8384
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
constant: false
initial concentration: 1.0
is: C06127
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: Digalactosylceramidesulfate
has only substance units: false

metaM ser L e
name: L-serine
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
is: CHEBI:17115
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR P450SCC1m
reversible: true
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000134
name: cholesterol monooxygenase
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176

metaR r1620
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110032#

metaR r0960
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110032#

metaM tsul c
name: thiosulfate(2-)
constant: false
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00257

metaM lnlncg e
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32391
is: SBO:0000247
name: gamma-linolenate
initial amount: NaN
is: HMDB03073
type: Species

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM 13dpg c
is: SBO:0000247
constant: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
initial amount: NaN
is: C00236
boundary condition: false
name: 3-Phospho-D-glyceroyl phosphate
initial concentration: 1.0
is: HMDB01270

metaR PROt2r
reactant: MODEL1310110032#
name: L-proline reversible transport via proton symport
fast: false
modifier: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_9cdb8445_fee9_4497_a0eb_215df45384b3
boundary condition: true
name: PEMT
is encoded by: hsa:10400
is: Q9UBM1
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR N4Tg
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110032#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f69bae7d_a32c_477e_a49c_4f939fad1817
name: CA4
is encoded by: hsa:762
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q6FHI7
has only substance units: false
initial concentration: NaN

metaR 2AMADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
product: MODEL1310110032#

metaM acgam r
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00215
type: Species
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_7066e11d_1898_41ec_9648_fbe3b9d706f4
name: NOS1
is: SBO:0000252
boundary condition: true
type: Species
is: B4DG68
has only substance units: false
is encoded by: hsa:4842
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f5abbfc5_4f6d_43fb_88d9_eab4be7b25e8
initial amount: NaN
is: B7Z3W8
constant: false
is encoded by: hsa:6536
name: SLC6A9
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR AHEXASE2ly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110032#
reversible: false

metaM 4ppcys m
initial concentration: 1.0
constant: false
is: HMDB01117
initial amount: NaN
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:59458
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: SBO:0000247

metaR ACACt2
type: Reaction
fast: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
name: acetoacetate transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
product: MODEL1310110032#
is described by: ECO:0000269

metaR r1623
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false

metaR r0961
reversible: false
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8aeb2a2b_0f2b_44d4_9eb9_d83dbcb61192
is: O00767
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6319
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: SCD
constant: false

metaM CE4872 c
type: Species
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM glc D r
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
initial concentration: 1.0
name: D-glucose
constant: false
is: CHEBI:4167
is: HMDB00122
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_2579c2ec_aa70_4bb0_8dce_a322c90c238a
boundary condition: true
name: CHAT
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
has only substance units: false
is: P28329

metaR CYTK14
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
name: cytidylate kinase (dCMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_ad03a15d_840c_437b_b22c_a94a68ceba90
is: SBO:0000252
is encoded by: hsa:292
has only substance units: false
initial amount: NaN
is: Q6NVC0
constant: false
name: SLC25A5
initial concentration: NaN
type: Species
boundary condition: true

metaM xtsn c
name: xanthosine
is: CHEBI:18107
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247
is: HMDB00299
type: Species
boundary condition: false
initial amount: NaN

metaR r2320
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00256
name: squalene
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15440

metaR RE0453M
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: RE0453
is: SBO:0000176
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM ha deg1 l
has only substance units: false
constant: false
name: hyaluronan degradation product 1
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
type: Species
is: CHEBI:16336
initial amount: NaN

metaR MANt4
is described by: ECO:0000269
type: Reaction
name: D-mannose transport via sodium cotransport
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185

metaR r1017
name: Vesicular transport
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:

metaM digalsgalside hs e
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8384
constant: false
is: C06127
boundary condition: false
name: Digalactosylceramidesulfate
has only substance units: false
type: Species
initial amount: NaN

metaR r0962
kinetic law: MODEL1310110032#
name: Facilitated diffusion
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_b7ab042f_a84f_4bdf_9901_b9f1daf2e702
has only substance units: false
is: SBO:0000252
is: Q9NYR8
initial amount: NaN
type: Species
name: RDH8
initial concentration: NaN
is encoded by: hsa:50700
constant: false
boundary condition: true

metaR r1622
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
reversible: true
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_b70c8e26_33ce_4d29_94d3_99f4f2e6788f
is encoded by: hsa:200010
type: Species
has only substance units: false
name: SLC5A9
is: SBO:0000252
is: E9PAK4
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_832c2c90_3c4e_4430_a380_84ee7caf1731
type: Species
is: Q9H999
name: PANK3
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:79646
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_0ffb0c63_6e1d_48c7_a6e4_8d1ed03ec969
name: ALDH1A2
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: F5H2Y9
is encoded by: hsa:8854
boundary condition: true
initial concentration: NaN

metaR r1512
product: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_53e74bcd_883f_44e8_a531_5e3834c3fe51
boundary condition: true
has only substance units: false
is: Q14642
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3632
initial amount: NaN
name: INPP5A

metaM 4ppcys c
type: Species
initial concentration: 1.0
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
is: CHEBI:59458
is: C04352
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01117

metaM o2s e
constant: false
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18421
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110032#_11350908_6cd8_4346_8e00_545d4001b997
name: _NM_013421_1_e
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NM 013421
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaM cholcoa c
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
is: CHEBI:57373
initial concentration: 1.0
constant: false
has only substance units: false
name: choloyl-CoA(4-)
boundary condition: false
type: Species
is: HMDB01374

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR r2329
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1018
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110032#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110032#
name: Transport reaction
is described by: ECO:0000000
type: Reaction
fast: false

metaM pi g
type: Species
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: CHEBI:43474
constant: false
initial amount: NaN
is: HMDB00973
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_6c5039d3_05c3_4264_92bf_0ad7c5e09fa2
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GPX4
is: P36969
is encoded by: hsa:2879

metaM fad r
name: Flavin adenine dinucleotide oxidized
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01248
constant: false
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
initial amount: NaN

metaR Ser Thrtg
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
name: Ser/Thr transport (from golgi to lysosome)
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

metaM ksi deg27 l
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: HMDB00143
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 27
initial concentration: 1.0

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
name: H2O transport, lysosomal

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM thp2c x
has only substance units: false
boundary condition: false
is: HMDB12130
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate
constant: false
is: CHEBI:16987

metaR GALASE19ly
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaR TDCHOLAte
name: bile acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#

metaR r1593
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ddb935cb_f775_4450_a969_9a3568c7ef1a
initial amount: NaN
is encoded by: hsa:33
type: Species
constant: false
initial concentration: NaN
name: ACADL
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P28330

metaM lnlc e
name: linoleate
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:30245
is: HMDB00673

metaR HISSNAT5tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8e306c72_219e_40cd_a767_ad6618078978
constant: false
has only substance units: false
is encoded by: hsa:M68895
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: _M68895_1_c

http://identifiers.org/biomodels.db/MODEL1310110032#_eb5fa31a_ba60_48cf_9cc2_df0c49ff5a00
has part: Q07837
is: SBO:0000297
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
has part: P82251
boundary condition: true
is encoded by: hsa:6519
name: SLC7A9:SLC3A1
is encoded by: hsa:11136

metaM pd3 c
is: HMDB06500
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
type: Species
initial amount: NaN
name: Previtamin D3

metaM 3aib D c
is: C03265
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
boundary condition: false
has only substance units: false
is: HMDB02299
constant: false
name: D-3-Amino-isobutanoate
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM adrn c
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: CHEBI:53487
is: SBO:0000247
is: HMDB02226
name: adrenic acid
constant: false

metaM ppcoa c
is: C00100
is: HMDB01275
constant: false
boundary condition: false
has only substance units: false
name: Propanoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57392
is: SBO:0000247
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR r1019
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110032#
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110032#

metaR GALtly
product: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110032#
name: galactose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110032#

metaM leuktrA4 c
name: leukotriene A4(1-)
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57463
is: HMDB01337
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_d5b52f47_4197_4219_adf2_129d4580c22c
initial amount: NaN
name: ENTPD2
has only substance units: false
is encoded by: hsa:954
is: Q5SPY7
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaR RE0453C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
fast: false
name: RE0453
is: SBO:0000176
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true

metaR RBTt
fast: false
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: ribitol transport via passive diffusion
is: SBO:0000185
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_1c7c2e60_6eaa_456b_b3e7_a8596bc95760
name: SLC29A2
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q14542
constant: false
is: SBO:0000252
is encoded by: hsa:3177
type: Species

metaM 4h2oglt m
is: SBO:0000247
constant: false
is: CHEBI:17742
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
name: 4-hydroxy-2-oxoglutarate(2-)

metaR UDPG4E
name: UDPglucose 4-epimerase
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
reactant: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.2

metaR BHBtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
fast: false
reactant: MODEL1310110032#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true

metaR r1594
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_1691fd38_bf47_49f0_9c96_4a8fcba97372
has only substance units: false
is: SBO:0000252
is: P00491
initial amount: NaN
is encoded by: hsa:4860
boundary condition: true
constant: false
initial concentration: NaN
name: PNP
type: Species

metaM mescon m
constant: false
is: HMDB00749
is: CHEBI:36986
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial concentration: 1.0
name: Mesaconate
type: Species

metaM pi e
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00009
is: HMDB00973
is: SBO:0000247
is: CHEBI:43474
has only substance units: false
type: Species
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false

metaR ASPGLUm
reversible: true
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110032#

metaR NH4tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
name: ammonia peroxisomal transport
product: MODEL1310110032#

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM o2s c
is: SBO:0000247
initial concentration: 1.0
name: superoxide
has only substance units: false
is: HMDB02168
constant: false
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: CHEBI:18421
type: Species

metaM hexdicoa r
boundary condition: false
is: HMDB00672
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
type: Species
name: hexadecanedioylcoa
initial amount: NaN
constant: false
is: SBO:0000247
is: C08260

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM h l
is: C00080
has only substance units: false
initial concentration: 1.0
name: proton
type: Species
constant: false
boundary condition: false
is: CHEBI:24636
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380

metaM retn c
initial concentration: 1.0
name: all-trans-retinoate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
is: CHEBI:35291
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaM idp n
type: Species
is: SBO:0000247
name: IDP(3-)
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
is: HMDB03335
has only substance units: false
is: CHEBI:58280
initial amount: NaN
initial concentration: 1.0

metaR SUCCTD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_957384ee_507e_40e0_b8ad_c89972b619a3
is encoded by: hsa:122622
is: B3KTV4
boundary condition: true
constant: false
has only substance units: false
type: Species
name: ADSSL1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8ca1b866_a126_4fac_8f6e_8dc05cfeb59a
name: PROSC
initial amount: NaN
boundary condition: true
is encoded by: hsa:11212
type: Species
constant: false
is: O94903
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR CTPS1
name: CTP synthase (NH3)
kinetic law: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (1503.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110032#
is described by: ECO:0000254

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR PGDI
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.3.99.2
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110032#
product: MODEL1310110032#
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is: SBO:0000176

metaR r1591
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
fast: false
reversible: true

metaR CERT1rt
kinetic law: MODEL1310110032#
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_df3398dc_aa64_456b_ab55_1ceb4593e4a2
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: HADHB
is encoded by: hsa:3032
initial concentration: NaN
boundary condition: true
is: P55084
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ac446d31_2e9d_4f2d_a5e2_9a19de6aa7df
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6567
initial concentration: NaN
constant: false
name: SLC16A2
is: P36021
type: Species
initial amount: NaN
has only substance units: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM ksi deg8 l
name: keratan sulfate I, degradation product 8
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
initial concentration: 1.0
is: HMDB00143
type: Species
is: CHEBI:12936
initial amount: NaN

metaM ser L c
is: HMDB00187
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
constant: false
is: CHEBI:17115
name: L-serine
boundary condition: false
has only substance units: false

metaM leuktrA4 e
initial amount: NaN
initial concentration: 1.0
type: Species
name: leukotriene A4(1-)
has only substance units: false
is: SBO:0000247
is: HMDB01337
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_0580a5c2_271b_4239_b3c1_4484e18b6f6f
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: ABAT
is encoded by: hsa:18

metaR SBT Dtde
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000134
reversible: true
name: D-sorbitol transport, extracellular

metaR DOPAt4 2 r
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Dopamine reversible transport in via sodium symport (1:2)
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM HC02203 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
name: prostaglandin-a2
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27820
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaM cspg b l
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
type: Species
is: CHEBI:16347
is: HMDB00062
constant: false
initial amount: NaN
is: C00318
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110032#_f4ffc9ee_d85d_44c9_be67_aa4b139585e8
initial amount: NaN
has only substance units: false
is encoded by: hsa:5315
is: SBO:0000252
is: P14618
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: PKM2

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial concentration: 1.0
has only substance units: false
is: CHEBI:57795
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR GLRASE
product: MODEL1310110032#
reversible: true
name: glucuronolactone reductase
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD

metaM core6 g
initial amount: NaN
has only substance units: false
is: C04383
is: SBO:0000247
name: Core 6
boundary condition: false
type: Species
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0

metaM nadph r
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005
is: HMDB00221
initial concentration: 1.0
is: CHEBI:57783

metaR r1592
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
fast: false

metaM val L m
is: CHEBI:16414
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
type: Species
name: L-valine
is: HMDB00883
initial amount: NaN

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
type: Species
is: CHEBI:27462
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
is: SBO:0000247

metaR r1629
reactant: MODEL1310110032#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cholp c
has only substance units: false
name: choline phosphate(1-)
is: CHEBI:295975
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR LEUKTRF4t
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
reversible: true
name: leukotriene F4 transport
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2325
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110032#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
fast: false

metaR CDPDAGtm
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true

metaM acgam l
initial amount: NaN
name: N-acetyl-D-glucosamine
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17411

metaR r1597
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110032#

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM s7p c
initial concentration: 1.0
is: HMDB01068
type: Species
constant: false
is: CHEBI:57483
is: C05382
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Sedoheptulose 7-phosphate

metaR r0553
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false

metaM pi c
initial amount: NaN
constant: false
is: C00009
is: HMDB00973
name: hydrogenphosphate
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2
boundary condition: false
is: CHEBI:43474
initial concentration: 1.0
type: Species

metaR r1963
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#

metaM hexdicoa x
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false
name: hexadecanedioylcoa
is: HMDB04047
constant: false
type: Species
is: C14143
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_bfa91e86_75f2_4ff8_a0a9_1b09196a56c6
initial concentration: NaN
is: Q5JPH6
is encoded by: hsa:124454
type: Species
constant: false
name: EARS2
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_970370fb_630d_45a9_9e9a_729315d9efb1
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q01581
name: HMGCS1
is encoded by: hsa:3157

metaR r1628
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110032#

metaR XYLK
is: SBO:0000176
kinetic law: MODEL1310110032#
name: xylulokinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9942.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.17 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.17
reactant: MODEL1310110032#

metaR r0968
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
reactant: MODEL1310110032#

metaR r2326
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR P5CR
product: MODEL1310110032#
reversible: false
name: pyrroline-5-carboxylate reductase
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_4681303e_4187_4b55_b0d2_69221708ad82
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: ACSS2
is encoded by: hsa:55902
has only substance units: false
initial amount: NaN
is: Q5QPH3
constant: false

metaR r1598
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM aicar e
is: C04677
type: Species
is: CHEBI:58475
is: SBO:0000247
initial concentration: 1.0
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

metaM h e
boundary condition: false
is: SBO:0000247
has only substance units: false
name: proton
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
is: C00080
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110032#_9258bca5_43c7_478c_94c1_42dc7fe6b3e1
name: CDS2
type: Species
has only substance units: false
is: O95674
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8760

metaR RE3628M
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
name: RE3628
reversible: true
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR HAS2
product: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
is described by: ECO:0000269
name: hyaluronan synthase

metaM adrncoa x
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
boundary condition: false
name: adrenyl coenzyme A
initial amount: NaN
is: C16170
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205480
initial concentration: 1.0
constant: false

metaM oh1 e
boundary condition: false
is: HMDB01039
has only substance units: false
is: SBO:0000247
name: hydroxide ion
constant: false
initial amount: NaN
type: Species
notes: FORMULA: HO CHARGE: -1
is: C01328
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_222bcd44_2dc9_48e2_986e_1bc1e882a1cb
initial amount: NaN
type: Species
is encoded by: hsa:4513
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: COX2
constant: false
is: Q7GXZ8

metaM n2m2nmn l
type: Species
constant: false
initial amount: NaN
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: HMDB00939
has only substance units: false
is: CHEBI:16680
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
is: SBO:0000247

metaM creat c
is: SBO:0000247
has only substance units: false
is: HMDB00064
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: creatine

metaR GLNt4
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
name: L-glutamine reversible transport via sodium symport
type: Reaction
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
reversible: false

metaR RE2660N
modifier: MODEL1310110032#
name: RE2660
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_c02318e5_f8ea_4649_91f7_e461bbdcf7db
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10317
name: B3GALT5
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8b1a3a81_cef6_49bd_92d4_9f9d4ceaab40
initial concentration: NaN
type: Species
initial amount: NaN
name: _T83654_1_e
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:T83654

http://identifiers.org/biomodels.db/MODEL1310110032#_687d4b43_81fc_4a1c_9dbd_2c35aff3a9d2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: Q9P0Z9
initial concentration: NaN
is encoded by: hsa:51268
name: PIPOX
type: Species

metaM apoC Lys btn m
boundary condition: false
type: Species
is: HMDB03134
constant: false
is: C05552
initial amount: NaN
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
is: SBO:0000247

metaR r2327
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6458c549_8f53_411d_b2b8_f85707116175
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SLC9A5
is: Q9NSW9
is encoded by: hsa:6553
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ea370a78_63dd_48c4_a300_cc08c45c0394
constant: false
name: NNT
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q13423
has only substance units: false
is encoded by: hsa:23530
boundary condition: true
initial amount: NaN

metaM nadph m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
is: HMDB00221
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57783
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

http://identifiers.org/biomodels.db/MODEL1310110032#_ab5036dd_df45_43c7_b767_7d7c46aa6e84
is: P23378
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: GLDC
type: Species
has only substance units: false
is encoded by: hsa:2731

http://identifiers.org/biomodels.db/MODEL1310110032#_d72f0ac1_2a6d_4dd8_878e_5bae58f0cf13
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2687
name: GGT5
is: SBO:0000252
boundary condition: true
is: P36269

metaM ocdcea r
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:0
is: HMDB00207
name: octadecenoate (n-C18:1)
boundary condition: false
type: Species
is: C00712
initial concentration: 1.0

metaR r1595
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_7a2af0bf_35f7_434a_a9d9_fbe26aefcd8c
type: Species
is encoded by: hsa:5337
constant: false
name: PLD1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q59EA4
boundary condition: true

metaR MTHFD2
product: MODEL1310110032#
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD)
reversible: true
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110032#_20ef0260_3036_43d5_bfc4_69cf7f17ee8f
type: Species
name: SLC26A1
has only substance units: false
is encoded by: hsa:10861
is: Q9H2B4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM 3oddcoa m
type: Species
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
name: 3-Oxododecanoyl-CoA
has only substance units: false
is: CHEBI:27868
is: HMDB03937
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_639d8b18_0343_43d0_b06b_fb31250b8ba3
constant: false
boundary condition: true
is encoded by: hsa:4700
has only substance units: false
is: P56556
type: Species
initial amount: NaN
name: NDUFA6
is: SBO:0000252
initial concentration: NaN

metaM aicar c
constant: false
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: C04677
is: HMDB01517
initial amount: NaN
type: Species
is: CHEBI:58475
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r2328
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_a8acc583_7f1e_4f1c_9f10_e44b13905bc2
has only substance units: false
initial amount: NaN
type: Species
name: BDH1
initial concentration: NaN
is encoded by: hsa:622
is: SBO:0000252
constant: false
boundary condition: true

metaM 3aib D e
is: HMDB02299
initial concentration: 1.0
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: C03265
boundary condition: false
type: Species

metaR CYTK10n
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ef8a2592_c141_4c06_a8d1_cd43756c2a14
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: _BE966236_1_c
is: SBO:0000252
is encoded by: hsa:BE966236
initial amount: NaN
boundary condition: true

metaR r2408
reversible: false
kinetic law: MODEL1310110032#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000

metaR ABTD
reversible: true
name: L-arabinitol 4-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7509272d_a24b_4621_bdf9_ca11754626a4
name: NDUFB5
is: O43674
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4711
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR r1966
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
type: Reaction
reversible: false

metaM h g
is: SBO:0000247
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
has only substance units: false
name: proton
constant: false
type: Species
is: CHEBI:24636
initial concentration: 1.0

metaR r0552
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_5230eba5_d70b_4faf_a68c_36d969bf1d87
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: RFK
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:55312
is: B2RDZ2

metaR r1596
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1397
name: carnitine acetyltransferase EC:2.3.1.7
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b8c2733a_f83e_474f_bf5a_d2e4783f5d78
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10317
boundary condition: true
initial amount: NaN
is: Q9Y2C3
type: Species
initial concentration: NaN
name: B3GALT5

metaM pail hs n
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
is: SBO:0000247

metaR HPYRDC
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
type: Reaction
reversible: false
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
name: hydroxypyruvate decarboxylase
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

metaM h2o2 x
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: CHEBI:16240
is: HMDB03125
is: C00027

metaM HC02214 e
is: CHEBI:28852
constant: false
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-f1alpha
boundary condition: false

metaM creat e
name: creatine
is: SBO:0000247
is: HMDB00064
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
constant: false
type: Species

metaM CE2418 m
is: SBO:0000247
boundary condition: false
is: HMDB11123
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial concentration: 1.0
is: CHEBI:28387

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM trdrd m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15967
initial amount: NaN
constant: false
type: Species
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false

metaM Rtotal2 e
constant: false
initial amount: NaN
is: SBO:0000247
is: C00255
is: HMDB00244
name: R total 2 position
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:3554
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110032#_b233c032_1aa8_4d7b_ac30_8f2ed6aebae2
boundary condition: true
is: Q07973
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1591
name: CYP24A1

metaR GLCt4
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true

metaR r0331
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reversible: false
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f626d7fd_cce0_4f6c_86c2_1de97d57b162
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:30833
name: NT5C
is: Q8TCD5
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r0522
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
type: Reaction
reactant: MODEL1310110032#

metaM 10fthf m
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
is: HMDB00972
boundary condition: false
constant: false
is: CHEBI:57454
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_faa025c3_b872_4b00_b792_17e590862275
is: SBO:0000252
name: TSTA3
type: Species
initial concentration: NaN
is encoded by: hsa:7264
is: Q13630
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM tsul m
is: CHEBI:16094
boundary condition: false
name: thiosulfate(2-)
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00257

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a6d46060_f26a_4ac1_8d9e_0668e520ec15
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:9197
is: O00400
boundary condition: true
name: SLC33A1
type: Species
has only substance units: false

metaR FAOXC200180m
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110032#
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110032#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176

metaM val L e
type: Species
is: HMDB00883
is: CHEBI:16414
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-valine
constant: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_c44a8626_cb7e_44ad_bd47_a3bed3ea2723
type: Species
is encoded by: hsa:7360
is: SBO:0000252
constant: false
name: UGP2
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_8ebf17fd_62e8_41a0_adbf_34346d5996aa
is encoded by: hsa:8560
type: Species
name: DEGS1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM dctp n
is: C00458
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00998
is: CHEBI:16311
name: dCTP
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2292752c_b920_4f55_a907_9e422d360497
has part: P16278
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4758
boundary condition: true
has part: Q99519
type: Species
is encoded by: hsa:2720
is encoded by: hsa:5476
is encoded by: hsa:2588
name: GALNS:GLB1:NEU1:CTSA
initial amount: NaN
constant: false
has only substance units: false
has part: P10619
has part: P34059

http://identifiers.org/biomodels.db/MODEL1310110032#_a6e21ba8_3009_4354_9533_0f166e97252b
is: B2R6S5
boundary condition: true
has only substance units: false
is encoded by: hsa:51727
constant: false
initial concentration: NaN
name: CMPK1
type: Species
initial amount: NaN
is: SBO:0000252

metaR RE3244R
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
name: RE3244
reactant: MODEL1310110032#

metaM pap g
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
is: CHEBI:58343
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaM HC01410 m
has only substance units: false
name: (2E)-Hexenoyl-CoA
initial amount: NaN
is: CHEBI:28706
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR LEUTA
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110032#
name: leucine transaminase
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
modifier: MODEL1310110032#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_c08ba3cd_d999_4282_8660_6e851aa62002
constant: false
is encoded by: hsa:55350
type: Species
is encoded by: hsa:8875
initial concentration: NaN
is: SBO:0000297
has only substance units: false
name: VNN3:VNN2:VNN1
initial amount: NaN
has part: O95498
boundary condition: true

metaM fgam c
constant: false
is: C04376
has only substance units: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: HMDB01308
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426

http://identifiers.org/biomodels.db/MODEL1310110032#_edb52086_1a56_426f_b94d_f5553e0b35a4
initial amount: NaN
type: Species
name: PRDX2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
has only substance units: false
constant: false

metaR PHEMEt
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000269
name: heme transport
modifier: MODEL1310110032#
reversible: false

metaR GLU5SAtmc
kinetic law: MODEL1310110032#
is described by: ECO:0000134
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
name: glutamate semi-aldehyde transport, mitochondrial
type: Reaction
fast: false
is: SBO:0000185

metaR PETOHMm hs
product: MODEL1310110032#
is described by: ECO:0000254
reactant: MODEL1310110032#
is: SBO:0000176
reversible: false
name: phosphatidylethanolamine N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.17
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
fast: false
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR RADH2
fast: false
name: retinal dehydrogenase (NADPH)
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#

metaM ru5p D r
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: CHEBI:58121
initial concentration: 1.0
type: Species
is: HMDB00618
has only substance units: false
initial amount: NaN
boundary condition: false

metaM Rtotal2 c
is: HMDB00095
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
initial amount: NaN
is: CHEBI:60377
initial concentration: 1.0
constant: false
is: C00055

metaM CE2435 m
name: trans,cis-deca-2,4-dienoyl-CoA
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57795

metaM idp e
initial concentration: 1.0
name: IDP(3-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03335
type: Species
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280

metaM uacgam c
is: HMDB00290
initial amount: NaN
is: CHEBI:57705
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_494dc739_9230_49b3_8fb0_cf1558544caf
is: Q6IBC0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: HMGCL
is encoded by: hsa:3155
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_525833de_8c13_4342_bdf5_609c01e45d52
has only substance units: false
constant: false
is: Q5MY95
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:377841
name: ENTPD8
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2a299fe3_9e1b_4c31_9328_ffe204db460c
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: GALNT1
initial amount: NaN
is encoded by: hsa:2589
initial concentration: NaN
is: Q10472

metaR PROSTGI2t
name: Prostaglandin I2 transport
kinetic law: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000185
type: Reaction
reversible: true

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM bhb e
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00011
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
boundary condition: false
is: CHEBI:10983
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM chol m
is: CHEBI:15354
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00097
is: SBO:0000247
type: Species
name: choline
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

http://identifiers.org/biomodels.db/MODEL1310110032#_97760112_8edf_4bfb_ba43_e70c49d1357e
constant: false
has part: A8K7W0
is encoded by: hsa:8875
has part: O95497
is: SBO:0000297
initial concentration: NaN
type: Species
has only substance units: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
boundary condition: true
initial amount: NaN
is encoded by: hsa:8876

http://identifiers.org/biomodels.db/MODEL1310110032#_d9a1c61b_e30b_4e5b_8245_815485f3b741
name: ALDH3A1
constant: false
is: P30838
is encoded by: hsa:218
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR r1464
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR r1396
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110032#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
name: EC:2.3.1.21
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_d21cfd68_58b4_4274_b01d_aceccfc2381f
type: Species
is: SBO:0000252
boundary condition: true
is: Q8N1Q1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:377677
name: CA13

metaR ASCBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
product: MODEL1310110032#
reversible: true
name: L-ascorbate transport via facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110032#_32454594_8928_40f2_ab08_d4311d0d9ea7
is: SBO:0000252
is: P19404
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4729
name: NDUFV2
initial amount: NaN
boundary condition: true

metaM h r
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: CHEBI:24636
is: SBO:0000247
constant: false
name: proton
boundary condition: false

metaR r0483
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reactant: MODEL1310110032#
reversible: true
fast: false
product: MODEL1310110032#
type: Reaction
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_55124197_1f23_4461_8c9c_4d8e088551b7
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:122481
initial amount: NaN
type: Species
boundary condition: true
name: AK7
is: Q96M32

http://identifiers.org/biomodels.db/MODEL1310110032#_b1d5a2b8_7cae_4f4d_a08d_dae94bcf630f
constant: false
is: Q15392
is encoded by: hsa:1718
boundary condition: true
name: DHCR24
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_9d0616d7_cb9e_4e21_ab27_5ae3c61b7798
type: Species
constant: false
name: UGCG
initial concentration: NaN
is encoded by: hsa:7357
is: SBO:0000252
is: Q16739
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_789b2130_c4e7_4c0b_abaf_3d10ada4681e
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10587
name: TXNRD2
is: SBO:0000252
constant: false
boundary condition: true

metaR THYOXt2
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110032#
name: T4 transport via facilitated diffusion
reversible: true
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#
product: MODEL1310110032#

metaR r0545
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110032#_cc0f045b_6bb2_44db_87cc_8fe8d16d634c
boundary condition: true
constant: false
is encoded by: hsa:5230
type: Species
is: SBO:0000252
name: PGK1
is: P00558
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM ksi deg24 l
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
has only substance units: false
initial concentration: 1.0
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 24
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:12936

metaR r0480
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_5365651d_435a_48d1_98ec_a1957ac51ba4
is: SBO:0000252
initial concentration: NaN
is: Q96NR8
constant: false
name: RDH12
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:145226

metaR r2497
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reactant: MODEL1310110032#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
is described by: ECO:0000000

metaR GALASE6ly
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#

metaR 3MOPt2im
type: Reaction
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
product: MODEL1310110032#
fast: false

metaR r1167
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
name: EC:2.3.1.26

metaM idp c
constant: false
type: Species
name: IDP(3-)
is: SBO:0000247
is: HMDB03335
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
is: CHEBI:58280
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_953d9e1f_158c_46fe_b223_72ad8d90678c
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
constant: false
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967
boundary condition: true
has part: B4E3E9
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_bbc9ceb3_2a55_48cd_9f78_c35d67a30f3a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O75251
initial amount: NaN
name: NDUFS7
is encoded by: hsa:374291
constant: false
is: SBO:0000252
type: Species

metaR ADSL2
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: adenylosuccinate lyase
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_5428b31b_5287_400d_a221_3cca2506c80d
boundary condition: true
initial amount: NaN
has only substance units: false
name: SUCLA2
is: E5KS60
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8803
initial concentration: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_4551f79a_54a2_4a60_985c_4cf57b8a038b
is: O95340
type: Species
name: PAPSS2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:9060
constant: false
boundary condition: true
initial concentration: NaN

metaR FUCtly
reversible: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
is described by: ECO:0000000
type: Reaction
name: L-fucose efflux from lysosome
is: SBO:0000185
fast: false
product: MODEL1310110032#

metaR AHC
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
modifier: MODEL1310110032#
name: adenosylhomocysteinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.1.1

http://identifiers.org/biomodels.db/MODEL1310110032#_3d5dadc8_e09e_413c_9699_c5cb8ffbe243
type: Species
initial concentration: NaN
is encoded by: hsa:1347
initial amount: NaN
is: SBO:0000252
name: COX7A2
has only substance units: false
is: H0UI06
constant: false
boundary condition: true

metaR RE2998M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
name: RE2998
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_85d4908e_9d39_4ff9_95e5_6a18462297ac
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4200
has only substance units: false
is: P23368
name: ME2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_89f72ad4_07eb_469f_a6f2_9fc0d1aa6553
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:51557
name: LGSN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q5TDP6
initial concentration: NaN

metaR ENGASE3ly
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110032#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110032#

metaM HC01118 r
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
name: presqualene diphosphate(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_23017259_f658_411f_9002_6141a3d767a9
is encoded by: hsa:1374
initial concentration: NaN
boundary condition: true
is: Q8WZ48
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: CPT1A
initial amount: NaN

metaR PPDOy
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_88dac14d_cb03_408a_92fb_c461a497e3e5
initial amount: NaN
is: SBO:0000252
is: O00483
name: NDUFA4
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4697
boundary condition: true
initial concentration: NaN

metaR r0547
product: MODEL1310110032#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
reversible: true
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110032#_e39a8c1f_0ab0_445a_ae8e_52fc1ef16c46
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: O75874
is encoded by: hsa:3417
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: IDH1

metaM ile L c
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:17191
initial concentration: 1.0
is: HMDB00172
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110032#_aae0cefc_75dc_4924_b8aa_e419f1807af8
boundary condition: true
is encoded by: hsa:51
name: ACOX1
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: B4DK61

metaM meoh e
is: HMDB01875
type: Species
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial amount: NaN
initial concentration: 1.0
constant: false
name: methanol
boundary condition: false
is: CHEBI:17790
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_3bd10261_8579_477e_862d_a242b487ba9c
initial concentration: NaN
is: SBO:0000252
name: _AA419122_1_c
type: Species
boundary condition: true
is encoded by: hsa:AA419122
has only substance units: false
constant: false
initial amount: NaN

metaR r0268
modifier: MODEL1310110032#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
type: Reaction

metaM pap c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00061
type: Species
is: CHEBI:58343
boundary condition: false
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_51313f95_abb8_43eb_a7dc_f306a3fab498
has only substance units: false
name: _BE042354_1_m
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:BE042354
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM uacgam g
type: Species
is: CHEBI:57705
is: HMDB00290
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110032#_e74a4954_7587_484d_af0b_8ce8d62a229b
is encoded by: hsa:23464
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: E2QC23
type: Species
name: GCAT
initial amount: NaN

metaR MTHFDm
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.4.3
product: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
fast: false
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110032#

metaR r1590
type: Reaction
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR FAOXC1811603m
product: MODEL1310110032#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
modifier: MODEL1310110032#
is described by: ECO:0000269
fast: false
reversible: false

metaM HC00718 c
type: Species
boundary condition: false
constant: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
initial amount: NaN
initial concentration: 1.0
name: N-methylethanolaminium phosphate(1-)
has only substance units: false
is: SBO:0000247

metaR 5OXPROt
is: SBO:0000185
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-oxoprolinate
product: MODEL1310110032#
is described by: ECO:0000134
type: Reaction

metaR IZPN
is: SBO:0000176
name: Imidazolonepropionase
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR XYLt
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: D-xylose reversible transport
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD

metaR PAPtg
is: SBO:0000185
reversible: false
name: adenosine 3',5'-bisphosphate Golgi transport
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110032#_22397d93_f11f_4e3b_9c48_9981a2134fd7
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:251
has only substance units: false
initial concentration: NaN
is: P10696
name: ALPPL2
is: SBO:0000252

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: true
product: MODEL1310110032#
fast: false
type: Reaction
name: RE3347
reactant: MODEL1310110032#

metaR THYOXt
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
name: T4 transport via bicarbonate countertransport

metaM h m
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: CHEBI:24636
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton
constant: false

metaR DNDPt29m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: false
product: MODEL1310110032#
is: SBO:0000185
name: dCDP transport via dADP antiport
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3d8e0700_5cb9_4f3b_a561_17c372dc5df7
is encoded by: hsa:5298
type: Species
initial concentration: NaN
is: Q9UBF8
name: PI4KB
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR PItg
fast: false
name: phosphate transport, Golgi apparatus
is: SBO:0000185
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

metaR RE1254C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110032#
name: RE1254
is: SBO:0000176
fast: false
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
reversible: true

metaR S2L2FN2M2MASNtly
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: false
fast: false
name: s2l2fn2m2masn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM tre e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
constant: false
is: HMDB00975
type: Species
is: C01083
name: Trehalose
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16551
boundary condition: false
is: SBO:0000247

metaR ADSL1
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
type: Reaction
reversible: false
name: adenylosuccinate lyase

http://identifiers.org/biomodels.db/MODEL1310110032#_3832652b_902b_4773_b6bf_aa4c723efbcc
constant: false
type: Species
initial amount: NaN
name: ASPA
is: SBO:0000252
is encoded by: hsa:443
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q6FH48

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3018a985_d006_4b1d_addc_ad4df985ff36
is encoded by: hsa:5831
is: A6NFM2
type: Species
boundary condition: true
initial concentration: NaN
name: PYCR1
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR r0523
reversible: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
product: MODEL1310110032#

metaM tdcoa x
boundary condition: false
initial amount: NaN
is: HMDB01521
has only substance units: false
is: C02593
constant: false
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
is: CHEBI:57385
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

metaR r2119
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110032#

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
boundary condition: false
is: CHEBI:24636
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: proton

metaR r0549
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.99.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.1.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false

metaR GGH 6THFe
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110032#
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

metaR DM anth
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction
reversible: true

metaR TRDR
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
name: thioredoxin reductase (NADPH)
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#

metaR CYTK10
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110032#_2951a53d_fd3c_471f_ac1e_401351e78c44
has only substance units: false
is: F5H066
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC12A4
constant: false
is encoded by: hsa:6560
type: Species

metaR RDH1a
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (all-trans,NADPH)
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176
type: Reaction
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ffb5869a_ba57_44f2_81bd_36c83972092c
boundary condition: true
is encoded by: hsa:2585
name: GALK2
is: Q01415
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_1893b883_e900_4691_a762_060a24d60ae9
name: SLC2A6
initial amount: NaN
boundary condition: true
is: Q9UGQ3
type: Species
is encoded by: hsa:11182
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaM itp e
type: Species
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
is: HMDB00189
constant: false
is: SBO:0000247
name: ITP(3-)
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM uri e
constant: false
is: CHEBI:16704
is: HMDB00296
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
boundary condition: false
is: C00299
type: Species
initial amount: NaN
name: Uridine
initial concentration: 1.0

metaM tdcoa m
is: SBO:0000247
has only substance units: false
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
initial concentration: 1.0
initial amount: NaN
is: C02593
boundary condition: false
constant: false

metaM udpacgal l
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
is: HMDB00304
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM co c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: carbon monoxide
constant: false
boundary condition: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
is: CHEBI:17245
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_85c0ce24_d3c5_4ace_9253_ae7d9f335127
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110032#_c3228f83_8aac_47ff_b58f_dd05a0a30799
boundary condition: true
is: O00400
name: SLC33A1
type: Species
constant: false
is encoded by: hsa:9197
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2117
is described by: ECO:0000000
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_802eb490_d73c_40d5_8992_617ea4866b81
constant: false
is: Q9BZX2
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7371
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: UCK2

http://identifiers.org/biomodels.db/MODEL1310110032#_5bd6379b_c518_47a9_b2ca_35fdb2e74099
name: SLC4A1
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6521
constant: false
initial amount: NaN
is: P02730
is: SBO:0000252
has only substance units: false

metaR CYTK11
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110032#
name: cytidylate kinase (dCMP,dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110032#
fast: false

metaM chol r
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15354
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0
type: Species
name: choline

metaR FACOAL181i
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
name: C181 fatty acid activation
product: MODEL1310110032#

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM dhbpt c
boundary condition: false
is: SBO:0000247
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
is: CHEBI:20680
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM biocyt c
constant: false
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
is: C05552
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
boundary condition: false
name: Biocytin
initial amount: NaN
is: HMDB03134
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_bcf11e01_58e7_410c_9c93_196517fa8421
is encoded by: hsa:191
initial amount: NaN
initial concentration: NaN
type: Species
is: B3KUN3
is: SBO:0000252
name: AHCY
constant: false
boundary condition: true
has only substance units: false

metaR ANTHte
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
fast: false
name: Transport of anthranilate
product: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110032#

metaR ST8SIA12
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: Beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.8
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110032#

metaR r0196
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110032#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110032#

metaM HC01162 c
constant: false
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
has only substance units: false
is: SBO:0000247
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species
is: CHEBI:58376
initial concentration: 1.0
boundary condition: false

metaM ocdcea e
constant: false
boundary condition: false
is: CHEBI:0
has only substance units: false
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: HMDB00207
is: SBO:0000247
is: C00712
name: octadecenoate (n-C18:1)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_622d1173_fa5d_455e_b132_7d93aebe8b52
name: PKLR
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5313
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_4990eb99_c07e_4b75_b6a4_928ed5530c01
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: _LOC727762_1_m
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:LOC727762

http://identifiers.org/biomodels.db/MODEL1310110032#_292d8727_c65f_45c7_af7c_d528766d6079
constant: false
name: PYCRL
is: SBO:0000252
is encoded by: hsa:65263
is: Q53H96
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR r0267
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR 5MTHFt
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis

metaR r2116
reversible: true
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7dd00c43_ddfa_448c_b4d0_6862bdf20fac
initial concentration: NaN
boundary condition: true
is: P24752
has only substance units: false
is encoded by: hsa:38
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: ACAT1

metaR F1Atg
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: F1alpha transport (from golgi to lysosome)
reactant: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_8cdb7c78_eb62_4bcc_b425_ce0394a0232c
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4706
is: O14561
initial amount: NaN
constant: false
name: NDUFAB1

metaR ST8SIA11
reactant: MODEL1310110032#
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
reversible: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR CYTK12
name: cytidylate kinase (dCMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110032#
is: SBO:0000176
type: Reaction

metaM hcys L c
is: HMDB00742
type: Species
is: CHEBI:17588
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
boundary condition: false
constant: false
initial concentration: 1.0
name: L-homocysteine

metaR DIDPtn
reactant: MODEL1310110032#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110032#
name: dIDP nuclear transport
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110032#

metaR B3GALT5g
product: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 5

metaM dttp e
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
is: CHEBI:37568
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01342
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_04cad340_e05e_42ba_bf6c_00a093d5f098
name: KL
initial amount: NaN
constant: false
is encoded by: hsa:9365
is: Q9UEF7
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_f282d30d_dac9_4808_b017_ea53a3a77cb6
type: Species
is: P25325
initial concentration: NaN
is encoded by: hsa:4357
boundary condition: true
is: SBO:0000252
constant: false
name: MPST
initial amount: NaN
has only substance units: false

metaM crm hs r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: N-acylsphingosine
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
type: Species
is: CHEBI:52639

metaM Lpipecol x
type: Species
name: L-pipecolic acid
is: HMDB00716
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: CHEBI:30913
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ac5d4cef_c3fa_4bad_9bad_867b7ead9fb5
type: Species
is: O75106
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AOC2
has only substance units: false
is encoded by: hsa:314

metaR CHLtm
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
name: choline transport via diffusion (cytosol to mitochondria)
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reversible: true

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: CHEBI:17191
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00172
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_b533ae58_a0a8_4f99_9ef3_4de41a9f3bf4
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: _AI684467_1_m
is encoded by: hsa:AI684467

metaR r0113
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
reversible: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:

metaR r2115
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
product: MODEL1310110032#
is: SBO:0000185

metaR r0818
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110032#
fast: false
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR CYTK7n
name: cytidylate kinase (CMP,UTP),nuclear
is described by: ECO:0000269
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3e6c7ec2_8f86_4981_8d1a_3b86ee5aebdc
has only substance units: false
is: SBO:0000252
is encoded by: hsa:113026
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PLCD3
constant: false
is: Q8N3E9

metaM meoh c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: methanol
has only substance units: false
is: HMDB01875
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
type: Species
is: CHEBI:17790
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_bb46b90c_13e3_48f0_965c_b54f79108593
is: Q9BX95
type: Species
initial concentration: NaN
is encoded by: hsa:81537
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SGPP1
boundary condition: true
constant: false

metaM co e
is: HMDB01361
initial concentration: 1.0
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: carbon monoxide
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_bf4199e4_47a7_4526_8575_98cf289c0fea
boundary condition: true
is encoded by: hsa:490
type: Species
name: ATP2B1
is: P20020
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_10eb556b_e7e5_4645_a971_ab71a740ab62
is encoded by: hsa:NM 013421
initial concentration: NaN
is: SBO:0000252
name: _NM_013421_1_m
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR r0527
reactant: MODEL1310110032#
type: Reaction
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110032#

metaR URCN
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: URCN
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.49
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110032#
fast: false

metaR CYTK13
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: cytidylate kinase (dCMP,dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_5de1c5ed_debe_471f_a2b4_547d5a5a23f1
name: HAO1
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q9UJM8
initial amount: NaN
boundary condition: true
is encoded by: hsa:54363

http://identifiers.org/biomodels.db/MODEL1310110032#_aeb10bb3_85d3_40e9_94fa_e151e11c3cee
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:100287639
has only substance units: false
name: _100287639_1_c
boundary condition: true

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR FADH2ETC
reversible: false
kinetic law: MODEL1310110032#
type: Reaction
fast: false
product: MODEL1310110032#
name: Complex II reaction for respiratory chain
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000134

metaM bhb m
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
has only substance units: false
is: HMDB00011
name: (R)-3-hydroxybutyrate
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_204a0fdb_7fd1_42d9_bf76_6cb3c1cd81e5
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NAGK
initial amount: NaN
is encoded by: hsa:55577
is: Q9UJ70
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_f92454b1_8509_4105_8f80_5fb6a17cca69
is: Q9BZV2
is: SBO:0000252
is encoded by: hsa:80704
initial amount: NaN
boundary condition: true
name: SLC19A3
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaM 2mb2coa m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57337
is: HMDB02054
initial amount: NaN
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
boundary condition: false
type: Species

metaM CE5236 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
is: SBO:0000247
is: HMDB03952
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaR r1467
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: Postulated transport reaction
fast: false
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110032#

metaR FUMSO3tm
is: SBO:0000185
kinetic law: MODEL1310110032#
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
type: Reaction
product: MODEL1310110032#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: HMDB01269
boundary condition: false
name: (R)-methylmalonyl-CoA(5-)
initial amount: NaN
is: CHEBI:57326
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM btamp c
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB04220
is: CHEBI:3110
type: Species
constant: false

metaM xyl D l
name: aldehydo-D-xylose
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15936
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
type: Species
constant: false

metaM ksi deg11 l
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 11
type: Species
constant: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r2114
reversible: true
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110032#
type: Reaction
is: SBO:0000185

metaR r0817
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110032#_aa851c8d_098d_4937_a556_98a11f07ab99
constant: false
type: Species
is encoded by: hsa:AA614647
has only substance units: false
initial amount: NaN
name: _AA614647_1_c
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR NAIt
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
name: Na+ / iodide cotransport
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
modifier: MODEL1310110032#
reversible: true

metaM udpg c
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58367
is: C00029
name: UDPglucose
is: HMDB00286
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaR OROTGLUt
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110032#

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15636
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_e544cfa9_b1ed_4c9d_9db3_e168e1559f88
is: Q9Y217
has only substance units: false
boundary condition: true
is encoded by: hsa:9107
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: MTMR6

http://identifiers.org/biomodels.db/MODEL1310110032#_573f0f75_721f_4bac_8675_90f63292cb8b
has only substance units: false
is: B4E3E9
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: OGDH
is encoded by: hsa:4967
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_595b7a08_db5c_4323_aef7_adeeadb147b5
has only substance units: false
is encoded by: hsa:AI378339
initial concentration: NaN
type: Species
name: _AI378339_1_m
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM dopasf e
boundary condition: false
name: dopamine 3-O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:37946
is: SBO:0000247

metaM dttp c
initial concentration: 1.0
is: CHEBI:37568
boundary condition: false
type: Species
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
has only substance units: false
constant: false
is: SBO:0000247
is: C00459
initial amount: NaN

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM udpglcur c
is: SBO:0000247
is: C00167
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00935
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
type: Species
is: CHEBI:58052

metaR r1466
name: EC:2.3.1.86
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_53519f0c_a7fc_4492_b7c9_d2c682ffb3ee
is: Q8TE04
name: PANK1
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:53354
type: Species

metaM chol n
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15354
is: HMDB00097
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: SBO:0000247
name: choline

metaR r2014
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR AKGMALtm
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000269
reversible: true

metaR UMPK7n
product: MODEL1310110032#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110032#
name: UMP kinase (dGTP),nuclear
modifier: MODEL1310110032#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_ec558f32_4c39_42e5_97a9_fd1d291eb3ca
type: Species
initial concentration: NaN
is: P23743
constant: false
name: DGKA
is encoded by: hsa:1606
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_19549da7_654d_49c8_9434_865cd6ca02bb
is: SBO:0000252
is encoded by: hsa:8528
constant: false
initial amount: NaN
initial concentration: NaN
is: Q99489
name: DDO
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_6de21c71_2090_4fb7_9d9d_c8344c22d11c
is: O43865
initial concentration: NaN
is: SBO:0000252
name: AHCYL1
constant: false
has only substance units: false
is encoded by: hsa:10768
boundary condition: true
initial amount: NaN
type: Species

metaM 2obut c
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
constant: false
is: SBO:0000247
is: C00109
is: CHEBI:16763
initial concentration: 1.0
boundary condition: false
name: 2-Oxobutanoate
is: HMDB00005
initial amount: NaN
has only substance units: false

metaR FACOAL160i
modifier: MODEL1310110032#
name: C160 fatty acid activation
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110032#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_4d0800e8_a7cc_431c_bf43_e9cbee0d86cd
has only substance units: false
name: ACAA2
is: P42765
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10449
type: Species
constant: false
boundary condition: true

metaR LTC4CP
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: Leukotriene C4 carboxypeptidase
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
fast: false
reactant: MODEL1310110032#
type: Reaction

metaR GALASE10ly
kinetic law: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110032#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction

metaR r2113
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

metaR 3SPYRSPm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_aff56730_f5a8_4716_8ea8_fa3450e09b95
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:83530
name: _83530_1_c
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR RE1342C
reversible: true
name: RE1342
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false

metaM h x
boundary condition: false
name: proton
is: CHEBI:24636
initial concentration: 1.0
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
is: C00080
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_745122d1_e788_4c98_9184_f8b774869047
is: SBO:0000252
name: HAS3
initial amount: NaN
type: Species
is encoded by: hsa:3038
boundary condition: true
has only substance units: false
is: O00219
constant: false
initial concentration: NaN

metaR CERT1gt
product: MODEL1310110032#
reversible: true
type: Reaction
modifier: MODEL1310110032#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
kinetic law: MODEL1310110032#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110032#
name: ceramide transport protein

metaR PItn
name: phosphate transport, nuclear
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM val L c
name: L-valine
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
has only substance units: false
is: CHEBI:16414
initial amount: NaN
boundary condition: false
is: HMDB00883
is: SBO:0000247
type: Species

metaR GALU
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
name: UTP-glucose-1-phosphate uridylyltransferase
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.7.9
fast: false
modifier: MODEL1310110032#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_bf6a1432_3216_4f1e_b67f_a37670045725
is: Q8IZH9
initial amount: NaN
name: GCH1
is: SBO:0000252
is encoded by: hsa:2643
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR ARACHDCOAtx
fast: false
is: SBO:0000185
product: MODEL1310110032#
reversible: true
name: fatty acid intracellular transport
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR FACOAL80i
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000269
name: fatty-acid--CoA ligase (octanoate)
modifier: MODEL1310110032#
is: SBO:0000176
reversible: false
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3

metaR r0193
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false

metaR XYLtly
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
fast: false
name: Xylose efflux from lysosome
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110032#

metaR r2112
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110032#_d7c5c26e_101a_4174_b9d1_46954e258707
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
has part: Q9UHI5
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000297

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
is: HMDB00189
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: ITP(3-)
initial concentration: 1.0

metaM dopasf c
name: dopamine 3-O-sulfate
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: CHEBI:37946
is: HMDB06275
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
is: CHEBI:16704
name: Uridine
type: Species
is: HMDB00296
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00299

http://identifiers.org/biomodels.db/MODEL1310110032#_03a337f1_043f_4504_ae95_22c11eef57d1
is: SBO:0000252
type: Species
initial concentration: NaN
is: P18283
is encoded by: hsa:2877
boundary condition: true
initial amount: NaN
has only substance units: false
name: GPX2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f8a88ebf_933d_4abf_8e60_9dd214699dbe
initial amount: NaN
name: GGT1
is: P19440
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2678
initial concentration: NaN

metaR r2017
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110032#_16c7f1dc_3391_46c8_aebe_441c7fec639b
constant: false
type: Species
is: Q96PD7
has only substance units: false
is: SBO:0000252
name: DGAT2
is encoded by: hsa:84649
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_2549a860_7cb8_46e8_929a_6f75ddf41ff4
name: SLC2A9
has only substance units: false
is: Q9NRM0
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:56606

http://identifiers.org/biomodels.db/MODEL1310110032#_1afa9889_8877_4995_bbc0_c4ffb47fc68e
initial amount: NaN
is: P48735
constant: false
name: IDH2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3418

http://identifiers.org/biomodels.db/MODEL1310110032#_38b29584_ddc4_4658_bed6_91394fe8ef21
initial amount: NaN
has only substance units: false
is encoded by: hsa:3423
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: P22304
name: IDS

metaR r2111
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaM ala L m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
constant: false
is: CHEBI:16977
type: Species
has only substance units: false
name: L-alanine
is: HMDB00161
is: SBO:0000247

metaR GGH 10FTHF7GLUe
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d4dadf72_f43f_4091_9ae7_d7776082de20
initial amount: NaN
has only substance units: false
is encoded by: hsa:AL038231
initial concentration: NaN
type: Species
name: _AL038231_1_c
is: SBO:0000252
constant: false
boundary condition: true

metaR NDPK7n
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110032#
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304
kinetic law: MODEL1310110032#
is: SBO:0000176
fast: false

metaM so4 c
type: Species
name: sulfate
is: CHEBI:16189
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
initial concentration: 1.0

metaM ocdcea c
boundary condition: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
type: Species
is: CHEBI:0
is: HMDB00207
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR r2016
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
reversible: false
is: SBO:0000185

metaM biocyt e
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB03134
type: Species
boundary condition: false
constant: false
name: Biocytin

metaR r1692
is described by: ECO:0000000
reversible: false
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_8cfb86eb_5c2c_49ae_be40_92604cffbe94
boundary condition: true
initial concentration: NaN
type: Species
name: SLCO3A1
constant: false
initial amount: NaN
is: Q9UIG8
has only substance units: false
is encoded by: hsa:28232
is: SBO:0000252

metaM 4abut m
is: HMDB00112
has only substance units: false
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: CHEBI:16865
boundary condition: false
constant: false
is: C00334
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM so4 e
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
is: CHEBI:16189
boundary condition: false
is: HMDB01448
type: Species
initial amount: NaN

metaR r2121
product: MODEL1310110032#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM HC02204 e
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:27624

metaM amp m
is: CHEBI:456215
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
type: Species
is: HMDB00045
is: SBO:0000247
name: AMP(2-)
initial concentration: 1.0

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR MANt1r
name: mannose transport (uniport)
modifier: MODEL1310110032#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110032#

metaR FAOXC2251836m
is described by: ECO:0000000
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
name: Beta oxidation of fatty acid
fast: false
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6647eb96_95b7_4f20_97fe_4a3f87b88438
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI824319
name: _AI824319_1_r
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM trdox c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
is: SBO:0000247
has only substance units: false
name: Oxidized thioredoxin
is: CHEBI:18191

metaM uacgam r
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
boundary condition: false
is: CHEBI:57705
is: HMDB00290
constant: false

metaR r1615
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR BILIRUBtr
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reversible: true
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110032#

metaR GALT
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
name: galactose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
reversible: true
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#

metaR r1587
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110032#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000

metaM od2coa c
initial amount: NaN
has only substance units: false
is: CHEBI:50570
is: HMDB06529
initial concentration: 1.0
is: C16218
name: trans-Octadec-2-enoyl-CoA
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
type: Species
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_0a4999a5_102c_41c5_8fb6_966575727a9b
is encoded by: hsa:60490
type: Species
initial amount: NaN
is: Q96CD2
name: PPCDC
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_87f5d8af_e503_446c_a9eb_2d7da0ca772d
has only substance units: false
name: _AA629629_1_m
is encoded by: hsa:AA629629
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR ACGALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
fast: false
is described by: ECO:0000000
name: N-acetyl-galactosamine lysosomal efflux
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2ff88418_ecc2_4bcc_9bd3_f1d53de162ee
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: DPYSL3
is: Q8IXW6
is encoded by: hsa:1809
boundary condition: true

metaR r2122
reactant: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_eee379df_c852_47fc_bc96_f2cd27762a3c
boundary condition: true
constant: false
is: O00754
has only substance units: false
name: MAN2B1
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4125

metaM HC10852 r
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:61540
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
name: palmitoleyl-CoA(4-)

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR ECOAH1m
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reactant: MODEL1310110032#
fast: false

metaR ACACT1r
reactant: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: acetyl-CoA C-acetyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM CE2434 m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
boundary condition: false
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_b8c91efb_5387_4b05_b022_a2c4c1a4b2d1
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P42126
name: ECI1
is encoded by: hsa:1632

metaM udpacgal c
is: HMDB00304
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fb61ba4d_62c6_4a00_8e25_6e92112facc3
initial concentration: NaN
name: CTSA
type: Species
is: P10619
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5476
initial amount: NaN
has only substance units: false

metaR r1614
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NACHEXA11ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176

metaR RE3568C
product: MODEL1310110032#
kinetic law: MODEL1310110032#
name: RE3568
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
fast: false
is: SBO:0000176

metaR r1588
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_1159cbd1_22d2_493d_b94d_6462c858919f
constant: false
boundary condition: true
name: SLCO1B1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:10599
is: SBO:0000252
is: Q9Y6L6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_2183c724_1261_4249_9293_d787e645731c
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3098
constant: false
initial amount: NaN
is: A8K7J7
type: Species
name: HK1

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR r2333
reversible: true
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9d84add3_88a7_43eb_9fe7_80342e535a60
is encoded by: hsa:1807
boundary condition: true
has only substance units: false
is: Q14117
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: DPYS
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_fee8761f_3d98_4166_a0ee_6a449f1485bc
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:83697
type: Species
constant: false
name: SLC4A9
is: E9PDK1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_061bed95_7718_4413_a39b_29314c7fb121
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
name: CAT
is: P04040
is encoded by: hsa:847
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_f5ae0ba6_4e40_40b4_b1b5_3f35bcc505a7
type: Species
has only substance units: false
name: _BF195998_1_x
is: SBO:0000252
is encoded by: hsa:BF195998
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM q10h2 e
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB13111
type: Species
name: Ubiquinol-10
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740

http://identifiers.org/biomodels.db/MODEL1310110032#_dcabdad1_31f4_4f07_9fad_25bc5e57b720
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: CHKB
is: A0PJM6
is encoded by: hsa:1120

metaM HC01603 c
is: C00234
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
constant: false
name: 10-Formyltetrahydrofolate

metaR It
reactant: MODEL1310110032#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reversible: true
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Iodide uniport
product: MODEL1310110032#
fast: false
type: Reaction

metaM dttp m
name: dTTP
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00459
initial concentration: 1.0
is: HMDB01342
is: CHEBI:37568
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_aa3e9bdc_5c72_403d_8df4_7149d7bcfef0
initial concentration: NaN
is: P15328
constant: false
name: FOLR1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348
type: Species
has only substance units: false
initial amount: NaN

metaR r1589
fast: false
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r0698
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.2.27
is: SBO:0000176
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r1866
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Y+LAT2 Utilized transport
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR RE0915E
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0915
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#

metaM pro L c
has only substance units: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
is: SBO:0000247
initial concentration: 1.0
is: HMDB00162
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17203

metaR r1613
modifier: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#

metaR GULNDer
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: gulonate dehydrogenase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110032#_6ab6cc54_9194_4bb7_bb19_1f59aa710aad
constant: false
is encoded by: hsa:4696
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA3
is: O95167
is: SBO:0000252
initial amount: NaN

metaM tdcoa c
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
is: SBO:0000247
is: HMDB01521
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
initial amount: NaN

metaR FAOXC204
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR ASPte
is described by: ECO:0000134
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
reversible: true
fast: false
name: diffusion of aspartate into blood
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_90f98cb5_14cd_4e0f_b0fa_c3b4f7aff938
name: ACSS1
is: Q9NUB1
boundary condition: true
has only substance units: false
is encoded by: hsa:84532
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2120
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_48e8b49d_a644_488d_b4ad_da091e22ea32
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:125
boundary condition: true
is: P00325
is: SBO:0000252
initial amount: NaN
name: ADH1B
type: Species

metaM thbpt c
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
constant: false
name: 5,6,7,8-tetrahydrobiopterin
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00027
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_c2b8d931_bad6_4648_a760_11e8de8b04ad
is: SBO:0000252
name: NDUFS1
is: P28331
has only substance units: false
is encoded by: hsa:4719
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM dttp n
name: dTTP
is: SBO:0000247
type: Species
boundary condition: false
is: C00459
constant: false
is: HMDB01342
is: CHEBI:37568
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
has only substance units: false

metaR r2334
product: MODEL1310110032#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110032#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110032#_9a416855_14b7_4565_8ea2_048c5705a6b9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q3KQV9
is encoded by: hsa:91373
has only substance units: false
name: UAP1L1
constant: false
initial amount: NaN
type: Species

metaM dcdp c
is: HMDB01245
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
has only substance units: false
is: CHEBI:58593
initial amount: NaN
is: C00705
is: SBO:0000247
name: dCDP

metaR r1612
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction

metaM 5forthf c
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
is: SBO:0000247
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00664
initial amount: NaN
is: HMDB01534
type: Species
constant: false

metaM 12ppd S c
is: CHEBI:29002
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: HMDB06213
type: Species
constant: false
name: (S)-propane-1,2-diol
has only substance units: false

metaR TYRTA
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: tyrosine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110032#
is: SBO:0000176

metaR r2331
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR FAS160COA
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C16:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000269

metaR HAtly
type: Reaction
fast: false
reversible: false
is: SBO:0000185
name: hyaluronan transport, extracellular to lysosome
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_6fdd2c78_b842_42d1_8de6_19ad83d4b4c8
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: _AI926493_1_c
initial concentration: NaN
is encoded by: hsa:AI926493
type: Species
boundary condition: true

metaM didp n
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:28823
is: HMDB03536
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r0973
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3ce55419_c9e5_406a_8784_60187a7f57f6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P56181
name: NDUFV3
initial amount: NaN
constant: false
is encoded by: hsa:4731
type: Species

metaR AIRCr
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.2.6
name: phosphoribosylaminoimidazole carboxylase

http://identifiers.org/biomodels.db/MODEL1310110032#_2c635da1_ea42_42b3_bd35_321524ce3f8d
is: SBO:0000252
type: Species
is encoded by: hsa:5337
constant: false
is: Q59EA4
has only substance units: false
name: PLD1
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR HYXNt
kinetic law: MODEL1310110032#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
name: Hypoxanthine transport
type: Reaction
modifier: MODEL1310110032#
reversible: true

metaM ksi deg33 l
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 33
constant: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
boundary condition: false
initial amount: NaN
is: HMDB00143
has only substance units: false

metaR r1611
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM fum m
constant: false
is: C00122
is: CHEBI:29806
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00134
type: Species
name: Fumarate
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaM ha pre1 l
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:16126
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1baedb52_64d1_48ae_9edb_9049534cfda1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55
is: P15309
boundary condition: true
constant: false
name: ACPP
type: Species
has only substance units: false

metaR r0074
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reversible: true
modifier: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_140b3938_de4c_4ccf_9279_0ca36ec72d32
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: CHKA
has only substance units: false
is encoded by: hsa:1119
boundary condition: true

metaR r2332
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM nh4 m
is: CHEBI:28938
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
constant: false
is: HMDB00051
is: C01342
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1f2d2e90_ea03_48e0_923d_54699644faa3
is encoded by: hsa:10327
is: SBO:0000252
name: AKR1A1
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaM thyox L e
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:18332
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
name: L-thyroxine

metaR GLYt7 311 r
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
reversible: true
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)

http://identifiers.org/biomodels.db/MODEL1310110032#_679a3203_95f7_48d6_a7d5_889e91e64c32
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8528
type: Species
constant: false
name: DDO
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_e85056ba_9abf_40fd_a8cb_ca6dfd28defb
is encoded by: hsa:8898
initial amount: NaN
name: MTMR2
initial concentration: NaN
is: SBO:0000252
is: A6NN98
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR r1610
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0974
type: Reaction
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185

metaM udpacgal g
constant: false
initial concentration: 1.0
is: HMDB00304
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57847

metaM nh4 n
boundary condition: false
is: HMDB00051
has only substance units: false
is: CHEBI:28938
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
name: ammonium

metaR DUDPtn
name: dUDP nuclear transport
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110032#_ed1d83c9_d592_48f5_b1f0_0bda4ca50b9a
is encoded by: hsa:11000
name: SLC27A3
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q5K4L6
has only substance units: false
boundary condition: true

metaM biocyt m
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
is: SBO:0000247
name: Biocytin
constant: false
is: C05552
initial concentration: 1.0
is: HMDB03134

metaM CE5236 n
is: SBO:0000247
type: Species
is: HMDB03952
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28002

metaM HC02204 c
constant: false
is: SBO:0000247
is: CHEBI:27624
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaM malcoa m
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57384
name: malonyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01175

metaR SADT
modifier: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110032#
name: sulfate adenylyltransferase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reactant: MODEL1310110032#

metaR DCMPDA
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
fast: false
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_2474ee25_3cb7_4859_9070_1ce57d6ca323
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_m
initial amount: NaN
constant: false

metaM betald c
has only substance units: false
is: SBO:0000247
is: HMDB01252
is: CHEBI:15710
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: betaine aldehyde
initial concentration: 1.0
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576

metaR RE1807C
reversible: true
name: RE1807
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_c6378767_887c_4602_a038_9544e0e18df7
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:570
name: BAAT
boundary condition: true
is: Q14032
constant: false
is: SBO:0000252
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_398f01d8_2a85_43ad_b410_6da6b0c442a9
is: SBO:0000297
name: DLD:GCSH:GLDC:AMT
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2653
boundary condition: true
is encoded by: hsa:275
has part: P48728
initial amount: NaN
is encoded by: hsa:2731
has part: P23378
has part: P23434
type: Species

metaR RE2626C
is: SBO:0000176
fast: false
product: MODEL1310110032#
name: RE2626
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

metaM ala L e
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
constant: false
is: HMDB00161
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16977
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_596fa9ed_50a5_4761_9027_d67ca1941c38
is: O76062
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: TM7SF2
is encoded by: hsa:7108
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_badf8d01_c6c7_44f6_b610_2acad119afc8
is: P80404
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: ABAT
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:18

http://identifiers.org/biomodels.db/MODEL1310110032#_59a77dbf_17a6_4730_87e1_30154605c818
boundary condition: true
initial amount: NaN
constant: false
is: Q6ZWP6
name: ACAD8
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:27034
initial concentration: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2430ab29_770b_42f3_9902_eea8317a0a47
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4710
has only substance units: false
name: NDUFB4
constant: false
initial amount: NaN
is: O95168

http://identifiers.org/biomodels.db/MODEL1310110032#_d22b9e04_3c36_4ba7_9e64_5f995b1f290c
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:56901
is: Q9NRX3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA4L2

metaR LEUPHELAT2tc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_07d6218f_9eb3_4632_865c_3b4036a0891c
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
name: SLC27A2
is encoded by: hsa:11001
initial concentration: NaN
initial amount: NaN
is: O14975

metaR r2330
fast: false
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaM amp r
is: CHEBI:456215
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
is: SBO:0000247
name: AMP
is: C00020
initial amount: NaN
is: HMDB00045

metaM 2dr5p c
name: 2-deoxy-D-ribose 5-phosphate(2-)
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
initial concentration: 1.0
is: CHEBI:57651
is: HMDB01031

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
name: ps_hs[m]
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18303
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_4ecde5bc_8f16_4b4b_a9d8_c89df262d269
is: Q5SYN6
is encoded by: hsa:6581
name: SLC22A3
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM sbcoa x
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
is: C14143
type: Species
is: HMDB04047

http://identifiers.org/biomodels.db/MODEL1310110032#_ed0d0a26_5b64_46e5_8fd4_0a54428099a4
is encoded by: hsa:219
boundary condition: true
constant: false
is: P30837
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: ALDH1B1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_10db5d04_b3f2_411f_983d_b8a101cd563e
initial amount: NaN
is encoded by: hsa:4830
is: SBO:0000297
boundary condition: true
has part: P22392
initial concentration: NaN
has part: P15531
type: Species
constant: false
has only substance units: false
is encoded by: hsa:4831
name: NME1:NME2

metaM ala L c
is: SBO:0000247
name: L-alanine
is: HMDB00161
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
type: Species

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r1863
product: MODEL1310110032#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000

metaR RE3245C
name: RE3245
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM HC01376 m
is: CHEBI:28692
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
has only substance units: false
constant: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_01fa8142_1088_4a7d_965f_809841aaecd2
is encoded by: hsa:AI291895
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: _AI291895_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_f1f44e1b_33d9_4bec_b926_324ec45e2832
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q9NVE7
is: SBO:0000252
initial amount: NaN
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229

metaR ACCOAgt
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
modifier: MODEL1310110032#
type: Reaction
name: acetyl-coa transport
product: MODEL1310110032#
reversible: true

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR LNLNCAt
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_d5f36658_79c8_47d0_aaa7_b26f645d5e09
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:204
initial amount: NaN
name: AK2
boundary condition: true
has only substance units: false

metaM 3otdcoa m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
initial amount: NaN
is: HMDB03935
name: 3-Oxotetradecanoyl-CoA
is: CHEBI:28726
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaR GALK
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.157
reversible: false
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/2.7.1.6
name: galactokinase
kinetic law: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaM so4 m
boundary condition: false
has only substance units: false
is: HMDB01448
type: Species
initial amount: NaN
is: CHEBI:16189
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial concentration: 1.0
name: sulfate

http://identifiers.org/biomodels.db/MODEL1310110032#_ec15081c_53a7_489d_950a_39a986c7c276
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P16260
is encoded by: hsa:8034
name: SLC25A16
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaM amp e
is: HMDB00045
name: AMP
is: SBO:0000247
is: CHEBI:456215
is: C00020
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

http://identifiers.org/biomodels.db/MODEL1310110032#_9f9902e6_22b9_4fea_a2bc_54d5b890fa8c
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: FOLR1
type: Species
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_92766e51_c1de_43df_9a19_cf27ebe8b18e
constant: false
is: SBO:0000252
is encoded by: hsa:375056
boundary condition: true
type: Species
has only substance units: false
name: MIA3
is: Q5JRA6
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_e8c2598b_3e2e_440b_bc54_1db1e6bdfad1
is: SBO:0000252
name: ACACB
initial concentration: NaN
boundary condition: true
type: Species
is: O00763
is encoded by: hsa:32
has only substance units: false
initial amount: NaN
constant: false

metaM ksi deg2 l
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01356
is: CHEBI:57312
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 2
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110032#_06b6e5fa_0e58_484d_a38c_11176c45832f
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: PRDX1
initial concentration: NaN
is encoded by: hsa:5052

metaM 10fthf e
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57454
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972

metaR PItx
fast: false
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110032#
name: Phosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110032#
reversible: true

metaR r0339
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.65

metaM 3hbcoa m
is: CHEBI:57316
constant: false
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
type: Species
has only substance units: false

metaR r0604
reactant: MODEL1310110032#
reversible: false
fast: false
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168

metaM gsn e
is: HMDB00133
initial amount: NaN
is: CHEBI:16750
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: C00387
boundary condition: false
name: Guanosine
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

metaM digalside hs c
is: http://identifiers.org/pubchem.compound/8383
constant: false
is: C06126
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
has only substance units: false
name: Digalactosylceramide

metaM tymsf c
type: Species
name: Tyramine O-sulfate
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247
initial concentration: 1.0
is: HMDB06409
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_74f3275d_8afc_4f8b_a8bd_80e90863918a
boundary condition: true
type: Species
initial concentration: NaN
name: EHHADH
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: Q9NY65
is encoded by: hsa:1962

metaM amp c
initial concentration: 1.0
is: HMDB00045
name: AMP
boundary condition: false
is: SBO:0000247
is: C00020
has only substance units: false
initial amount: NaN
is: CHEBI:3322
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_a92c1089_375c_47e6_9b11_6f71e7a941bd
boundary condition: true
is encoded by: hsa:4712
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4731
constant: false
initial concentration: NaN
type: Species
has part: Q5VYT2
initial amount: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110032#_13e3aa06_0f3d_43b8_a899_0ee4cecc99bb
is: Q14410
boundary condition: true
name: GK2
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2712
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_04109c72_05b3_4ff9_9f59_79b41d771f26
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI934540
type: Species
name: _AI934540_1_c
has only substance units: false

metaM so4 l
constant: false
is: CHEBI:16189
name: sulfate
has only substance units: false
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR 13DAMPPOX
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reactant: MODEL1310110032#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110032#
is: SBO:0000176
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_bd480871_fae0_4471_9ff4_6d25c452ce8b
is: G3V0F6
constant: false
name: DGKZ
is: SBO:0000252
is encoded by: hsa:8525
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM 5adtststerones c
is: HMDB06278
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
has only substance units: false

metaR r1580
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM glyald m
type: Species
is: HMDB01051
is: CHEBI:17378
initial concentration: 1.0
boundary condition: false
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

metaR MALSO3tm
is described by: ECO:0000269
modifier: MODEL1310110032#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: Malate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110032#_694e2134_d47e_4771_8d2e_4d5fa49b3007
is encoded by: hsa:2595
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: Q8TET4
name: GANC
type: Species
is: SBO:0000252
has only substance units: false

metaR MTHFCm
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#

metaR NMNATr
product: MODEL1310110032#
fast: false
name: nicotinamide-nucleotide adenylyltransferase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269

metaR GLYt2r
product: MODEL1310110032#
is described by: ECO:0000304
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: glycine reversible transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0b828d8a_e361_40f7_990b_5229d2fc7c4f
initial concentration: NaN
is: Q12882
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: DPYD
is encoded by: hsa:1806
is: SBO:0000252

metaR CSPG Btly
name: chondroitin sulfate B transport, extracellular to lysosome
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
is: CHEBI:58052
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00935
is: C00167
constant: false
name: UDP-D-glucuronate

metaR r0752
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
modifier: MODEL1310110032#
is: SBO:0000176
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000

metaR r0975
type: Reaction
reactant: MODEL1310110032#
name: Facilitated diffusion
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

metaR MALSO4tm
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
name: Malate:sulfate antiport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000269

metaR r1581
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#

metaM 10fthf c
is: CHEBI:57454
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
initial amount: NaN
constant: false
name: 10-Formyltetrahydrofolate
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110032#_8cfb76ca_38ea_40d3_8763_a67204140f01
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9BV79
is encoded by: hsa:51102
type: Species
initial concentration: NaN
has only substance units: false
name: MECR

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
reversible: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_69dd4c64_6168_42ba_851d_073ed821b8c6
type: Species
constant: false
name: ND3
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4537
has only substance units: false
is: P03897
is: SBO:0000252

metaM rbt e
boundary condition: false
is: HMDB00508
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
type: Species
is: CHEBI:15963
initial amount: NaN
name: D-ribitol
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_56ec5ea4_8d14_462c_b935_1ab05c6ba0da
boundary condition: true
has only substance units: false
is encoded by: hsa:55568
type: Species
initial amount: NaN
name: GALNT10
constant: false
initial concentration: NaN
is: SBO:0000252

metaR H2Oter
type: Reaction
fast: false
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
name: H2O endoplasmic reticulum transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM dcdp m
initial amount: NaN
is: HMDB01245
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: dCDP(3-)
boundary condition: false
has only substance units: false

metaM fru e
initial concentration: 1.0
is: CHEBI:15824
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: D-Fructose
is: HMDB00660
is: C00095
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095

metaM sebcoa x
initial concentration: 1.0
name: sebacoylcoa
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: C14143
is: HMDB04047
constant: false

metaM gsn c
initial concentration: 1.0
is: CHEBI:16750
is: HMDB00133
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: C00387
name: Guanosine
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

http://identifiers.org/biomodels.db/MODEL1310110032#_8b902106_5b21_4e75_ae2e_799ea2782ee3
initial amount: NaN
is encoded by: hsa:4712
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q5VYT2
name: NDUFB6

metaM tymsf e
has only substance units: false
name: Tyramine O-sulfate
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB06409
constant: false

metaR ACNACNGALGBSIDEte
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
name: acnacngalgbside hs transport
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_86d237d9_1b77_4f17_906b_7cbffe60547b
has only substance units: false
name: COX5B
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: Q53YB7
is encoded by: hsa:1329
is: SBO:0000252
initial concentration: NaN

metaM rbt c
initial concentration: 1.0
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247
name: D-ribitol
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR VALt5m
name: Valine reversible mitochondrial transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
is: SBO:0000185
product: MODEL1310110032#

metaR B3GALTg
name: Beta galactosyltransferase
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_87ef98b7_833b_4301_a383_f8b10d3f7f95
has only substance units: false
name: _AI373818_1_m
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI373818
initial amount: NaN

metaR ACOAD8m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.10
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
type: Reaction
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
kinetic law: MODEL1310110032#

metaM ha pre1 e
has only substance units: false
is: CHEBI:16126
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM mlthf c
is: HMDB01533
initial amount: NaN
is: CHEBI:15636
is: SBO:0000247
constant: false
type: Species
is: C00143
has only substance units: false
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false

metaR UAGALDP
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110032#
name: UDP-N-acetylgalactosamine diphosphorylase
fast: false
product: MODEL1310110032#

metaM nh4 c
is: SBO:0000247
has only substance units: false
is: C01342
constant: false
name: Ammonium
boundary condition: false
is: HMDB00051
initial amount: NaN
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
initial concentration: 1.0

metaM 5adtststerones e
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
type: Species
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaR r1177
reversible: false
kinetic law: MODEL1310110032#
name: EC:3.1.1.13
product: MODEL1310110032#
is: SBO:0000176
fast: false
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_dedcc739_9b0c_43f2_b32a_fb7d5518c25f
initial amount: NaN
is: P03915
has only substance units: false
initial concentration: NaN
name: ND5
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4540
type: Species

metaM hdca e
is: SBO:0000247
is: HMDB00220
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:0
is: C00249
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1
name: Hexadecanoate (n-C16:0)
type: Species

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM biliverd c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
type: Species
name: biliverdin(2-)
is: HMDB01008
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57991
boundary condition: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM thyox L c
is: SBO:0000247
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
has only substance units: false
boundary condition: false
is: HMDB00248
initial concentration: 1.0
is: CHEBI:18332
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_f5dcb640_5a9d_4c35_ad7d_ac0c906b5484
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: B3GALT5
type: Species
is encoded by: hsa:10317
constant: false
initial amount: NaN

metaM pro L e
is: CHEBI:17203
has only substance units: false
boundary condition: false
constant: false
name: L-proline
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_5624a9dc_8b94_49df_9f4a_994f5d8b819d
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:2109
initial amount: NaN
is: SBO:0000297
has part: P38117
name: ETFA:ETFB
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_dd55971d_7fa9_4bc4_9003_d46686dee2d6
is encoded by: hsa:AI935189
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AI935189_1_m

metaR BHBt
reversible: true
fast: false
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000

metaR r1619
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM q10h2 c
initial concentration: 1.0
is: HMDB13111
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
has only substance units: false
constant: false
name: Ubiquinol-10

metaM fru c
constant: false
boundary condition: false
is: CHEBI:15824
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00660
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
initial concentration: 1.0

metaM damp c
type: Species
is: HMDB00905
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: dAMP(2-)
is: SBO:0000247
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
constant: false

metaM HC01406 m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: 3-Oxooctanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
constant: false
is: CHEBI:28264

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false
is: CHEBI:57454
initial concentration: 1.0
initial amount: NaN
is: HMDB00972
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
boundary condition: false

metaR r1583
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110032#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1172
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: EC:3.1.1.13
kinetic law: MODEL1310110032#

metaR RE3218C
reversible: true
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
is described by: ECO:0000000
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
is: SBO:0000176
name: RE3218
kinetic law: MODEL1310110032#
type: Reaction

metaR SERGLNexR
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000304
reactant: MODEL1310110032#
is: SBO:0000185
modifier: MODEL1310110032#
reversible: true
type: Reaction
name: L-Serine/Glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110032#_671f8a51_4946_4e45_b365_fa9253940114
has only substance units: false
is: Q8TDY1
constant: false
is encoded by: hsa:8706
boundary condition: true
name: B3GALNT1
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR r0753
reversible: true
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000

metaM digalside hs g
initial amount: NaN
is: http://identifiers.org/pubchem.compound/8383
constant: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Digalactosylceramide
initial concentration: 1.0
type: Species

metaR NDP7er
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110032#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM 4nph e
is: HMDB01232
has only substance units: false
name: 4-nitrophenolate
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57917
boundary condition: false
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

metaM pro D e
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
type: Species
initial concentration: 1.0
name: D-proline
is: CHEBI:16313
initial amount: NaN
is: SBO:0000247

metaR EX fucfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leb glycolipid exchange
type: Reaction

metaR ACNACNGALGBSIDEtg
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110032#

metaR r1618
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM HC00682 m
initial concentration: 1.0
notes: FORMULA: C10H19NO2S2 CHARGE: 0 INCHI: InChI=1S/C10H19NO2S2/c1-8(12)15-9(6-7-14)4-2-3-5-10(11)13/h9,14H,2-7H2,1H3,(H2,11,13) EHMN_ABBREVIATION: C01136
is: CHEBI:16807
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: S-Acetyldihydrolipoamide

metaM 4nphsf c
is: HMDB06492
name: 4-Nitrophenyl sulfate
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
initial concentration: 1.0
is: CHEBI:35422
initial amount: NaN

metaM malcoa r
is: CHEBI:57384
boundary condition: false
type: Species
name: malonyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
has only substance units: false

metaR 7DHCHSTEROLtr
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
name: cholesterol precursor intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM fum c
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
is: HMDB00134
is: C00122
initial amount: NaN
initial concentration: 1.0
name: Fumarate
is: CHEBI:29806

metaR r1584
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110032#
type: Reaction

metaR ALAtN1
name: Alanine transport (Na, H coupled)
type: Reaction
reversible: true
fast: false
product: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

http://identifiers.org/biomodels.db/MODEL1310110032#_bb93e51b_3119_4255_a318_bc69d6e5cfa7
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3613
initial amount: NaN
is: O14732
is: SBO:0000252
type: Species
name: IMPA2
has only substance units: false
constant: false

metaM hdca c
is: SBO:0000247
has only substance units: false
is: HMDB00220
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
initial concentration: 1.0
constant: false
name: palmitate
is: CHEBI:7896
boundary condition: false

metaM nh4 e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
type: Species
boundary condition: false
name: ammonium
is: CHEBI:28938
constant: false

metaR RE1534M
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: RE1534
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM ps hs c
is: SBO:0000247
name: ps_hs[c]
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
constant: false
is: CHEBI:18303
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0541
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#

metaR r0603
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.12
is described by: ECO:0000000
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110032#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_138511b5_9d6e_4fc7_8b0c_0bbd93e0d1b8
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: ENTPD8
is: Q5MY95
type: Species
is encoded by: hsa:377841
boundary condition: true

metaM pnto R c
is: HMDB00210
name: (R)-Pantothenate
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
has only substance units: false
is: CHEBI:7916

metaR r1617
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_2fc4623c_1737_4921_b319_44cc2f7d4358
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI024818
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AI024818_1_c

metaM didp c
initial concentration: 1.0
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
has only substance units: false
is: CHEBI:28823
is: SBO:0000247
boundary condition: false
is: HMDB03536
constant: false
type: Species

metaR r1585
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_beb87a67_d153_4407_a1a4_4a8f01f8f51e
type: Species
name: FOLR3
initial amount: NaN
is encoded by: hsa:2352
boundary condition: true
is: SBO:0000252
is: Q05C14
initial concentration: NaN
constant: false
has only substance units: false

metaR r1586
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110032#

metaM 4nph c
name: 4-nitrophenolate
is: HMDB01232
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57917

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR ALAR
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
fast: false
type: Reaction
modifier: MODEL1310110032#
name: alanine racemase
kinetic law: MODEL1310110032#
is described by: ECO:0000212

metaR CYTK11n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
modifier: MODEL1310110032#

metaR r2338
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
fast: false

metaR r1616
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_59dfcc19_d5fb_46e9_8d71_2621f9a8e199
name: CAD
boundary condition: true
is: P27708
constant: false
is encoded by: hsa:790
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR PYRt2m
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110032#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR PAPStg
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
type: Reaction

metaM succoa x
name: Succinyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
constant: false

metaM 3odcoa m
boundary condition: false
is: HMDB03939
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Oxodecanoyl-CoA
is: SBO:0000247
is: CHEBI:28528
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265

http://identifiers.org/biomodels.db/MODEL1310110032#_903a71af_f68a_487f_92bf_8794f254f1c0
is encoded by: hsa:6530
boundary condition: true
constant: false
name: SLC6A2
has only substance units: false
is: Q96KH8
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b9e0a4a2_282d_4c10_9293_8c894460f64f
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: SLC25A4
is: P12235
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:291

metaR TCHOLAtx
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR CYSGLTH
type: Reaction
name: Glutathione:cystine oxidoreductase
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#

metaM ps hs e
is: CHEBI:18303
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
initial concentration: 1.0
constant: false
name: phosphatidylserine

metaM udpg r
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58367
boundary condition: false
constant: false
is: HMDB00286
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0

metaM ksi deg1 l
is: HMDB00174
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18287
constant: false
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 1
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
product: MODEL1310110032#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#

metaR HDCAter
name: palmitate ER export
reactant: MODEL1310110032#
fast: false
product: MODEL1310110032#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true
type: Reaction

metaR r0345
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110032#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

metaM HC02213 c
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
name: prostaglandin-e3
initial concentration: 1.0
is: CHEBI:28031

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: CHEBI:58478
is: HMDB06211
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: C04640
has only substance units: false
initial concentration: 1.0
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
constant: false

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_9423aa59_1d61_4bc7_b366_5ce73178a324
name: ACAD9
is encoded by: hsa:28976
initial amount: NaN
type: Species
boundary condition: true
is: Q9H845
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR r0407
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_3ad4315b_fc82_495e_8567_47341822d66d
initial concentration: NaN
constant: false
is: E9PCI1
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: ACP2
is encoded by: hsa:53
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_0f6c605a_997e_4ace_9122_62dd73b4a151
initial amount: NaN
is: SBO:0000252
name: AKR7A2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8574
constant: false
is: O43488
boundary condition: true

metaM HC00900 c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
has only substance units: false
name: Methylmalonate
boundary condition: false
constant: false
is: CHEBI:30860
initial amount: NaN

metaR ORNt4m
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110032#
product: MODEL1310110032#
name: ornithine mitochondrial transport exchange with citruline
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_3df8a542_63f7_4faa_af04_195601d07a31
boundary condition: true
is: P05091
initial concentration: NaN
has only substance units: false
name: ALDH2
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:217

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_c599403b_9fe1_47a3_b55d_761aab07a1d9
initial concentration: NaN
constant: false
is encoded by: hsa:4704
type: Species
has only substance units: false
name: NDUFA9
initial amount: NaN
is: SBO:0000252
is: Q16795
boundary condition: true

metaR FUT34g
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.65
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: false
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_432b7e1e_4ccf_446a_bf6d_26b16ec63562
initial concentration: NaN
is encoded by: hsa:6483
has only substance units: false
type: Species
name: ST3GAL2
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q16842

http://identifiers.org/biomodels.db/MODEL1310110032#_99aefd52_e25a_4ddb_92e8_8f1856e97ba9
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5019
is: P55809
name: OXCT1
has only substance units: false

metaM thym e
is: HMDB00262
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
name: thymine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17821

http://identifiers.org/biomodels.db/MODEL1310110032#_1a0dbdbf_e463_42ce_8e33_837a9a78eb48
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFA9
is: Q16795
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4704

metaM accoa c
boundary condition: false
is: HMDB01206
initial amount: NaN
is: SBO:0000247
constant: false
is: C00024
initial concentration: 1.0
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
has only substance units: false
name: Acetyl-CoA

metaR MGCHrm
is described by: ECO:0000269
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
reversible: true
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial

metaM lac L e
is: SBO:0000247
constant: false
is: HMDB00190
boundary condition: false
is: CHEBI:16651
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
type: Species
has only substance units: false
name: (S)-lactate

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f57e5102_d373_483d_bddb_c54276a063bf
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:83715
is: B1AK53
name: ESPN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM fadh2 m
constant: false
initial concentration: 1.0
is: CHEBI:58307
is: SBO:0000247
has only substance units: false
is: C01352
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01197
name: Flavin adenine dinucleotide reduced
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaM CE2424 m
boundary condition: false
is: SBO:0000247
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
is: CHEBI:28387
constant: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_b6bb751b_845f_4543_8213_594054af98dc
constant: false
has only substance units: false
is encoded by: hsa:204
initial amount: NaN
name: AK2
is: P54819
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM ddcacoa m
has only substance units: false
initial concentration: 1.0
is: CHEBI:57375
is: C01832
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)

metaM pyr e
is: SBO:0000247
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
is: HMDB00243
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: pyruvate
is: CHEBI:15361

metaM dnad c
initial amount: NaN
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: C00857
boundary condition: false
type: Species
has only substance units: false
constant: false
name: Deamino-NAD+
initial concentration: 1.0
is: CHEBI:18304
is: SBO:0000247
is: HMDB01179

metaR 24 25VITD3Hm
name: 24R-Vitamin D-25-hydroxylase (D3)
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.126
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1591.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15358094,PMID:8266831 NOTES:based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE2240M
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_0bf015f6_2b5f_44dd_be6c_4d9ceb5f9c0a
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC24A4
boundary condition: true
is encoded by: hsa:123041
type: Species

metaM 20ahchsterol m
type: Species
is: HMDB06283
is: SBO:0000247
initial amount: NaN
is: CHEBI:1296
name: 20-hydroxycholesterol
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM frdp x
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
boundary condition: false
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:175763

metaR ITCOALm
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: true
fast: false
is described by: ECO:0000212
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

metaR TREHe
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.28
reversible: false
product: MODEL1310110032#
fast: false
name: alpha,alpha-trehalase
is: SBO:0000176
modifier: MODEL1310110032#
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_e4ee716c_c305_47d9_a99c_14bfbe26a745
is: O76062
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:7108
initial concentration: NaN
name: TM7SF2
initial amount: NaN
type: Species

metaM Rtotal2coa c
is: SBO:0000247
is: HMDB00095
is: CHEBI:60377
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
constant: false
has only substance units: false
is: C00055
name: R total 2 coenzyme A
initial concentration: 1.0
type: Species

metaR ALOX52
is version of: http://identifiers.org/ec-code/1.13.11.34
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_db3f2d9f_de5a_4f8c_8513_d24d9d290f33
is: SBO:0000252
is: C9JC79
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6342
type: Species
name: SCP2
initial amount: NaN
constant: false

metaR HSD3A2r
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
modifier: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reactant: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225

http://identifiers.org/biomodels.db/MODEL1310110032#_122072a0_1b2c_42c2_b240_baab4e87777b
name: DGKB
type: Species
is encoded by: hsa:1607
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_139a6663_f171_4776_9a64_464ee2604e69
has only substance units: false
is encoded by: hsa:27124
type: Species
initial concentration: NaN
is: SBO:0000252
name: INPP5J
constant: false
initial amount: NaN
boundary condition: true

metaR SIAT9g
fast: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.9
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reversible: false
is described by: ECO:0000000

metaR PI45PLC
product: MODEL1310110032#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

metaR r0514
product: MODEL1310110032#
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
type: Reaction
modifier: MODEL1310110032#

metaM mi145p c
is: SBO:0000247
is: HMDB01498
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:203600
type: Species
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245

metaM ttdca c
is: HMDB00806
has only substance units: false
boundary condition: false
name: myristate
type: Species
constant: false
is: CHEBI:30807
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424

http://identifiers.org/biomodels.db/MODEL1310110032#_59050178_9cdc_4427_8abe_fe2af29d19c7
boundary condition: true
initial amount: NaN
name: _AI697028_1_m
constant: false
type: Species
is encoded by: hsa:AI697028
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_97101bd8_3fe1_4ad8_be62_96be628efeac
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:386757
name: SLC6A10P
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

metaR H2Otm
modifier: MODEL1310110032#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110032#
name: H2O transport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
reversible: true
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_599f4f60_9e0b_4807_909a_87f4c75ffe8e
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DEGS1
is: O15121
type: Species
is encoded by: hsa:8560

metaR IDOURte
is described by: ECO:0000134
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: L-iduronate transport, extracellular

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_5735a767_90b5_4e6e_bf21_bf958cbcb1a8
has only substance units: false
constant: false
name: _AA526438_1_m
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA526438

metaM dcdp n
is: HMDB01245
initial amount: NaN
initial concentration: 1.0
name: dCDP(3-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: CHEBI:58593
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_b9c940af_0f3a_4d26_9dd2_21f634310290
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: GALNTL2
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:117248
is: Q8N3T1

metaM lac L c
is: HMDB00190
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16651
is: SBO:0000247
name: (S)-lactate
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaM HC02149 c
initial amount: NaN
name: O-Propanoylcarnitine
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: CHEBI:28867
has only substance units: false

metaM 2mp2coa m
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01011
has only substance units: false
initial amount: NaN
is: CHEBI:27754
type: Species
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA

metaM succoa m
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01022
has only substance units: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
is: CHEBI:57292
type: Species
initial concentration: 1.0

metaR r0408
reactant: MODEL1310110032#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaM pyr c
is: CHEBI:15361
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1
initial concentration: 1.0
is: HMDB00243
constant: false
name: pyruvate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_a5400b0f_4128_4856_8363_721508cfc5b8
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4833
name: NME4
initial amount: NaN
constant: false
is: O00746
boundary condition: true
type: Species
has only substance units: false

metaR ADSK
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
name: adenylyl-sulfate kinase
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR MECOALm
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110032#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110032#
is described by: ECO:0000212

metaR XOL27OHtm
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110032#
name: 27 hydroxy cholesterol transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

metaR GLACter
product: MODEL1310110032#
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110032#
name: CO transporter via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_b3059273_90a9_46aa_84fe_69256846579c
name: CPT1B
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q92523
constant: false
initial concentration: NaN
is encoded by: hsa:1375

metaM cyst L c
is: HMDB00099
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
constant: false
has only substance units: false
is: CHEBI:17482
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-cystathionine

http://identifiers.org/biomodels.db/MODEL1310110032#_0e7c3b93_b3c4_4c57_b727_d91f8e2a4b1c
type: Species
name: GART
constant: false
is: SBO:0000252
is: Q59HH3
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:2618

http://identifiers.org/biomodels.db/MODEL1310110032#_04683652_a271_401c_97b4_8b73c1599108
is encoded by: hsa:1808
is: B4DR31
has only substance units: false
boundary condition: true
name: DPYSL2
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_e4a017df_1b39_4c35_abe2_05fc69b66f3b
initial concentration: NaN
is encoded by: hsa:6536
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: P48067
is: SBO:0000252
name: SLC6A9

metaM ksi deg29 l
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: SBO:0000247
name: keratan sulfate I, degradation product 29
type: Species
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
has only substance units: false

metaR Htr
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: true
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false

metaM omhpal c
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: HMDB06294
is: SBO:0000247
notes: FORMULA: C16H30O3 CHARGE: -1
type: Species
name: w-hydroxypalmiticacid
has only substance units: false

metaM methf m
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB01354
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
initial concentration: 1.0
is: CHEBI:57455

metaM fadh2 r
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial amount: NaN
is: HMDB01197
is: CHEBI:58307
is: SBO:0000247
name: FADH2(2-)
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9fd3403e_2c0c_4835_b294_6253ef17fb62
boundary condition: true
type: Species
is: Q6P4B4
is encoded by: hsa:5198
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: PFAS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_6558f29e_af73_4cb5_a0cd_de50fe2a6dc4
name: SLC2A2
is: SBO:0000252
is: P11168
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6514
has only substance units: false

metaM fe2 c
is: CHEBI:29033
name: Fe2+
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00692
constant: false
is: C00023
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_2afb32e1_01df_4903_ba90_304e18fb095c
initial concentration: NaN
name: RDH11
is: B4DDW0
is encoded by: hsa:51109
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR H2Otg
type: Reaction
name: H2O transport, Golgi apparatus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#

metaR MI134P4P
name: inositol-1,3,4-trisphosphate 4-phosphatase
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
fast: false

metaR GLYt7 211 r
product: MODEL1310110032#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#

metaM gal1p c
is: SBO:0000247
is: HMDB00645
boundary condition: false
initial concentration: 1.0
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
initial amount: NaN
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
has only substance units: false
is: CHEBI:58336

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
boundary condition: false
initial amount: NaN
name: Phosphodimethylethanolamine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:31997
has only substance units: false
type: Species
constant: false

metaM cdp c
is: CHEBI:58069
initial concentration: 1.0
is: C00112
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
name: CDP
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01546
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_69886438_a160_42cd_8a13_d9288ac64310
initial concentration: NaN
is encoded by: hsa:5169
has only substance units: false
boundary condition: true
is: Q308M7
type: Species
constant: false
initial amount: NaN
name: ENPP3
is: SBO:0000252

metaR URAt
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000269
type: Reaction
name: uracil transport via facilated diffusion

metaM cit e
name: citrate(3-)
is: SBO:0000247
constant: false
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: HMDB00094
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaM arachcrn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
is: HMDB06460
has only substance units: false
name: arachidyl carnitine
type: Species
initial amount: NaN

metaM gmp c
initial concentration: 1.0
has only substance units: false
is: C00144
boundary condition: false
is: CHEBI:58115
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
initial amount: NaN
type: Species
is: HMDB01397
name: GMP

metaM thf e
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57453
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0

metaM ach c
name: acetylcholine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15355
has only substance units: false
constant: false
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: HMDB00895
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_a72aa924_afe2_4a30_b4e7_aec172a3a343
type: Species
is: Q9Y5L3
has only substance units: false
initial concentration: NaN
name: ENTPD2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:954
initial amount: NaN
constant: false

metaM 2oxoadp c
boundary condition: false
is: CHEBI:57499
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
name: 2-oxoadipate(2-)
initial concentration: 1.0
has only substance units: false
constant: false

metaR UMPK4n
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
fast: false
name: UMP kinase (GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269

metaM prostge2 c
is: HMDB01220
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
has only substance units: false
name: prostaglandin E2(1-)

http://identifiers.org/biomodels.db/MODEL1310110032#_980eda60_080c_429a_a0c3_dd950c0186ab
is: SBO:0000252
is: Q9UJS0
initial concentration: NaN
name: SLC25A13
constant: false
boundary condition: true
is encoded by: hsa:10165
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_4d5b5754_44ee_405f_871e_9408aace8317
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4714
name: NDUFB8
constant: false
is: O95169
is: SBO:0000252

metaR NACHEXA13ly
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal

metaM accoa g
initial concentration: 1.0
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: HMDB01206
has only substance units: false
boundary condition: false
name: acetyl-CoA(4-)
is: CHEBI:57288
initial amount: NaN
type: Species

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM pmtcrn x
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: L-palmitoylcarnitine
is: CHEBI:17490
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
type: Species
initial amount: NaN

metaM HC02213 e
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin-e3
boundary condition: false

metaR ALAGLNexR
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d332b973_41b2_47c9_8ce9_d3548168d51e
is encoded by: hsa:AV717590
name: _AV717590_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_57bcd8f8_27a8_465d_8f79_a58ea2741319
initial amount: NaN
constant: false
is encoded by: hsa:AL050025
name: _AL050025_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaM btn m
is: CHEBI:57586
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00030
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaR DESAT20 1
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
fast: false
type: Reaction
kinetic law: MODEL1310110032#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000

metaR RE0830C
reactant: MODEL1310110032#
name: RE0830
fast: false
product: MODEL1310110032#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true

metaM fe2 e
is: HMDB00692
is: SBO:0000247
is: C00023
initial concentration: 1.0
is: CHEBI:29033
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
boundary condition: false
constant: false
has only substance units: false
type: Species
name: Fe2+

metaR RE1447N
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: RE1447
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

metaR AMETt2m
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reversible: true
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
modifier: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#

metaM m2mn l
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06537
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
boundary condition: false
constant: false
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
has only substance units: false

metaM glyc3p c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00093
is: HMDB00126
name: Glycerol 3-phosphate
type: Species
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
has only substance units: false
is: CHEBI:57597

metaR UGLCNACtg
fast: false
type: Reaction
name: UDP-GlcNAc Golgi transport via CMP antiport
kinetic law: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110032#
reversible: true
is: SBO:0000185
modifier: MODEL1310110032#
product: MODEL1310110032#

metaM cdp e
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01546
is: CHEBI:58069

metaR URIt
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110032#
name: uridine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110032#

metaM itacon m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB02092
name: itaconate(2-)
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: CHEBI:17240

metaR 25HVITD3tin m
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
name: 25-hydroxyvitamin D3 transport in mitochondria
reversible: false
is: SBO:0000185

metaM thf c
is: HMDB01846
boundary condition: false
is: CHEBI:57453
constant: false
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
initial amount: NaN
is: C00101
type: Species
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0

metaR r0579
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.13.11.19
is: SBO:0000176
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110032#
fast: false

metaR XANtx
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110032#
name: xanthine diffusion in peroxisome
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110032#

metaM cit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: C00158
is: CHEBI:16947
is: SBO:0000247
constant: false
has only substance units: false
name: Citrate
is: HMDB00094
boundary condition: false
type: Species
initial amount: NaN

metaM thym c
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
is: C00178
is: HMDB00262
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:17821
has only substance units: false
type: Species
is: SBO:0000247
name: Thymine

metaR r0236
product: MODEL1310110032#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reversible: true

metaR FAOXC14C12x
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM prostge2 e
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
name: prostaglandin E2(1-)
has only substance units: false

metaR O2ter
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, endoplasmic reticulum
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM strdnccoa m
is: HMDB06519
is: http://identifiers.org/pubchem.compound/47205473
initial concentration: 1.0
type: Species
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_59968796_9a14_41e8_82de_f34628b4ba21
is: P78381
is encoded by: hsa:7355
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
name: SLC35A2
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_487b75eb_2f9e_4557_a0d4_145ae09894fd
is: Q16348
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6565
type: Species
name: SLC15A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_904d4f20_8197_40b1_a350_4a9eea3a9281
is: Q15067
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: ACOX1
is: SBO:0000252
is encoded by: hsa:51

metaR CREATt4 2 r
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Creatine transport (sodium symport) (2:1)
reversible: true
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185

metaR GALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
is described by: ECO:0000000
name: galactocerebroside intracellular transport
reversible: true
reactant: MODEL1310110032#
type: Reaction

metaM srtn e
initial amount: NaN
name: serotonin(1+)
is: HMDB00259
boundary condition: false
is: CHEBI:350546
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

metaR 4NPHSULT
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is described by: ECO:0000269
name: 4-Nitrophenol Sulfotransferase
reactant: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
modifier: MODEL1310110032#
type: Reaction

metaR NAt3 1
name: sodium proton antiporter (H:NA is 1:1)
fast: false
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaR r0450
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
kinetic law: MODEL1310110032#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
reactant: MODEL1310110032#

metaR r2124
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110032#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_a24c6eb3_2dc2_4543_9c70_c88a8a193952
is: SBO:0000252
has only substance units: false
name: ADO
is: B3KXN9
constant: false
is encoded by: hsa:84890
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_9c3883f8_aea3_4a75_9c90_0d87d2064728
initial amount: NaN
is: P11166
name: SLC2A1
type: Species
initial concentration: NaN
is encoded by: hsa:6513
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaM his L c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: L-histidine
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00177
is: CHEBI:15971
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

metaR PI4PLC
type: Reaction
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
reactant: MODEL1310110032#

metaM 2hb c
initial concentration: 1.0
initial amount: NaN
name: 2-Hydroxybutyrate
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
constant: false
is: HMDB00008
is: CHEBI:1148

metaM nh4 x
constant: false
has only substance units: false
boundary condition: false
is: HMDB00051
type: Species
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: SBO:0000247
is: C01342
name: Ammonium
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_d60d3de2_f77b_466f_8972_2c49b01d14d9
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O43674
is encoded by: hsa:4711
type: Species
constant: false
name: NDUFB5
boundary condition: true

metaR FUCFUCGALACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
is described by: ECO:0000000
fast: false
type: Reaction
name: blood group intracellular transport
reversible: true
kinetic law: MODEL1310110032#

metaR r1433
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: RE2649
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_1a2d577c_cd21_45a4_a451_00591bfe6148
name: _AU149534_1_e
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AU149534
is: SBO:0000252
has only substance units: false
type: Species

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR FUT12g
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.4.1.69
modifier: MODEL1310110032#
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110032#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_06bbf421_01bb_45e4_a464_bdea37008c7d
initial concentration: NaN
initial amount: NaN
name: GALNT9
boundary condition: true
is encoded by: hsa:50614
has only substance units: false
is: Q9HCQ5
type: Species
constant: false
is: SBO:0000252

metaR r2123
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM c14dccoa x
is: C14143
is: HMDB04047
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
name: tetradecanedioylcoa

metaM btn c
is: HMDB00030
type: Species
is: C00120
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
initial amount: NaN
is: CHEBI:3420
initial concentration: 1.0
name: Biotin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_1fd5592f_a9b9_4f51_830c_e54e45d144a2
is: SBO:0000252
is encoded by: hsa:AW299740
has only substance units: false
name: _AW299740_1_m
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_8ee85c2e_1918_49a0_adaa_f4b1f5bf8b3b
initial concentration: NaN
type: Species
is encoded by: hsa:9963
constant: false
is: Q9UHI7
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC23A1
initial amount: NaN

metaR RE1447M
reactant: MODEL1310110032#
reversible: true
name: RE1447
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110032#
fast: false
type: Reaction

metaR r0129
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
product: MODEL1310110032#
reversible: true
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction

metaM pyr m
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
name: pyruvate
initial concentration: 1.0
is: CHEBI:15361
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: C00022
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_0956dc44_66a0_4cdc_83c7_66d2773fdb21
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:29926
name: GMPPA
boundary condition: true
type: Species
initial concentration: NaN
is: Q96IJ6
initial amount: NaN

metaM thym m
is: HMDB00262
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: thymine
is: SBO:0000247
is: CHEBI:17821
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_64a606d2_78f4_4228_a8be_7e28ebf969ac
name: SHMT1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6470
is: SBO:0000252

metaR GASNASEly
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26

http://identifiers.org/biomodels.db/MODEL1310110032#_e4c3d391_f783_4a4e_9beb_90642f798537
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:204
is: SBO:0000252
name: AK2
boundary condition: true
constant: false

metaR FACOAL180i
name: C180 fatty acid activation
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false

metaM HC02149 m
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:28867
name: O-Propanoylcarnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR RE2079R
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
name: RE2079
kinetic law: MODEL1310110032#

metaM srtn c
name: serotonin(1+)
initial amount: NaN
boundary condition: false
is: HMDB00259
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
is: SBO:0000247

metaM his L e
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15971
type: Species
name: L-histidine
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_8663cf0d_d002_40ba_acf7_66d19e0452ca
is: B3KNC1
boundary condition: true
is encoded by: hsa:51733
type: Species
is: SBO:0000252
initial concentration: NaN
name: UPB1
initial amount: NaN
has only substance units: false
constant: false

metaR CRNtHa
is: SBO:0000185
name: L-carnitine outward transport (H+ antiport)
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
kinetic law: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110032#
modifier: MODEL1310110032#

metaM 2hb e
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:1148
is: SBO:0000247
is: HMDB00008
initial amount: NaN
boundary condition: false
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

http://identifiers.org/biomodels.db/MODEL1310110032#_6e6d2f47_c8a4_47dd_b769_2cacccce945b
initial amount: NaN
initial concentration: NaN
is: F8W682
name: SLC4A2
is encoded by: hsa:6522
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_b88c854a_3b08_4f4e_84ff_ace01009e726
boundary condition: true
is: Q85KV6
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:4535
name: ND1
initial amount: NaN
type: Species
has only substance units: false

metaR r0829
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
fast: false
modifier: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
product: MODEL1310110032#
is described by: ECO:0000000

metaR r2126
is described by: ECO:0000000
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaR ACITL
is version of: http://identifiers.org/ec-code/2.3.3.8
reversible: false
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000176
name: ATP-Citrate lyase
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
kinetic law: MODEL1310110032#

metaR FUCFUCGALACGLCGALGLUSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
reversible: true
fast: false
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction

metaR MALtm
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false
name: malate transport, mitochondrial
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_2ac526ec_6ae9_49be_9a6f_614e0c36b0f0
name: PYCRL
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q53H96
constant: false
boundary condition: true
is encoded by: hsa:65263
initial amount: NaN

metaR RE0830N
name: RE0830
kinetic law: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true

metaM frdp r
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:175763
name: Farnesyl diphosphate
has only substance units: false
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
type: Species
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110032#_dc16ca2e_0e33_4c50_93d9_db7e4d171526
name: FOLR1
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110032#

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_02ab70cf_238b_4db9_aa4b_188492117554
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4831
name: NME2
constant: false
initial concentration: NaN
initial amount: NaN
is: P22392

metaR r0400
fast: false
type: Reaction
kinetic law: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110032#

metaR RE2954C
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
name: RE2954
reactant: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_a80be45e_f00f_4965_b4af_8b8592b475a6
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3033
has only substance units: false
name: HADH
is: SBO:0000252
initial concentration: NaN
is: Q16836
initial amount: NaN

metaR r0688
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3

metaR TTDCAFATPc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR GULN3D
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110032#_bb58f2c7_fc01_4546_af75_2881dde1e70c
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O75355
is encoded by: hsa:956
name: ENTPD3
boundary condition: true
type: Species

metaR DM atp c
reactant: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
name: DM_atp(c)
type: Reaction
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: false

metaR PRISTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#

metaR r1640
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR FTHFL
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
name: Formate-tetrahydrofolate ligase
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_30de01b8_b5a1_4c26_a95a_4bb6b42d5b77
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:AA021081
has only substance units: false
initial amount: NaN
name: _AA021081_1_r

metaR GALASE13ly
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110032#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_af6f098c_6393_49cd_a8df_ca4cbd12a1dc
name: NDUFS5
constant: false
is: Q6IBA0
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4725

http://identifiers.org/biomodels.db/MODEL1310110032#_bd8a079d_ce75_4be0_92e6_aaba6e27afec
initial concentration: NaN
is encoded by: hsa:2645
boundary condition: true
is: Q53Y25
has only substance units: false
constant: false
is: SBO:0000252
name: GCK
type: Species
initial amount: NaN

metaR r0403
reactant: MODEL1310110032#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_1b9c9cc1_7e5a_44e1_a92d_e594d8cc634e
type: Species
has only substance units: false
is: SBO:0000252
is: Q96GL6
name: SLC18A1
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6570
initial amount: NaN

metaR r2128
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM pmtcrn r
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: CHEBI:17490
is: SBO:0000247
constant: false
is: HMDB00222
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-palmitoylcarnitine

metaR ACHEe
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
name: Acetylcholinesterase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.1.7

metaM glyb c
constant: false
type: Species
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:17750
name: glycine betaine
is: HMDB00043
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_fe4d428f_9dd9_4c64_8d0a_829be57fa8da
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: ADSL
is encoded by: hsa:158

http://identifiers.org/biomodels.db/MODEL1310110032#_f7d2d38d_1c62_422a_b44b_09a12f040100
is: SBO:0000297
name: HADHA:HADHB
boundary condition: true
has part: P55084
initial amount: NaN
has part: E9KL44
is encoded by: hsa:3030
constant: false
is encoded by: hsa:3032
has only substance units: false
type: Species
initial concentration: NaN

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM thf m
is: CHEBI:57453
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
is: C00101
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01846
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

http://identifiers.org/biomodels.db/MODEL1310110032#_4e1af8f3_ca4e_4fb6_814c_e94eb4f905df
is: SBO:0000297
has part: P08195
type: Species
name: SLC7A10:SLC3A2
initial concentration: NaN
constant: false
has part: Q9NS82
is encoded by: hsa:56301
is encoded by: hsa:6520
initial amount: NaN
has only substance units: false
boundary condition: true

metaR Htx
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
name: H transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reactant: MODEL1310110032#
reversible: true

metaM cit m
is: HMDB00094
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16947
is: C00158
name: Citrate

metaR ACOAO7p
product: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal

metaR OCDCAtr
is: SBO:0000185
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true

metaR NACHEX21ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110032#
reversible: false
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7d6afd48_6b1e_4045_a888_c3724c52ec63
is: Q02338
is: SBO:0000252
is encoded by: hsa:622
initial concentration: NaN
boundary condition: true
name: BDH1
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR r1641
fast: false
reversible: true
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110032#_e494bbd0_1089_4f7c_953d_729798228c53
name: RRM2
is: P31350
initial amount: NaN
is encoded by: hsa:6241
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_4ab07e79_81d2_4132_b3f6_25cfc0502a0c
type: Species
boundary condition: true
is encoded by: hsa:4716
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: NDUFB10
is: A8K761
initial amount: NaN

metaM thcholstoic c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
has only substance units: false
type: Species
constant: false
is: CHEBI:18402
initial amount: NaN

metaR r2127
reactant: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2352
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR RTOTALFATPc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM 34dhmald m
constant: false
is: HMDB06242
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
is: C05577
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR r1642
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185

metaR r1435
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
fast: false
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_b2ea55f3_3309_416b_8771_8b612c4ecc9b
name: SLC38A2
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:54407
is: SBO:0000252
initial amount: NaN
type: Species
is: Q96QD8
has only substance units: false

metaR ALCD21 D
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
kinetic law: MODEL1310110032#
type: Reaction
name: alcohol dehydrogenase (D-1,2-propanediol)
is described by: ECO:0000304
fast: false
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR r0717
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110032#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:

metaR 4HPRO LTte
name: Transport of trans-4-hydroxy-L-proline
kinetic law: MODEL1310110032#
product: MODEL1310110032#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_55839f75_b4c6_4a76_8616_bf3a5158d14a
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: SDHA
boundary condition: true
is encoded by: hsa:6389
constant: false
is: P31040
initial amount: NaN

metaR SIAASE2ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_ea617da4_6e83_4085_bd92_d7a654739d2c
name: _NOS2A_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NOS2A
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM methf c
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
is: SBO:0000247
name: 5,10-Methenyltetrahydrofolate
has only substance units: false
is: CHEBI:57455
is: C00445
type: Species

metaR MGSA2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
name: methyglyoxylate synthase 2 (from g3p)
reversible: false
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is: SBO:0000176

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM ddcacoa x
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial amount: NaN
is: HMDB03571
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: CHEBI:57375
is: C01832
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_c987feb6_ed12_414f_9c84_083ac445c817
initial amount: NaN
is encoded by: hsa:92579
constant: false
is: Q9BUM1
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: G6PC3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_4845c9b5_bb67_4c92_b01f_c515c9ef392a
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P30084
is: SBO:0000252
is encoded by: hsa:1892
constant: false
name: ECHS1

metaM btn e
is: CHEBI:3420
initial concentration: 1.0
is: HMDB00030
has only substance units: false
type: Species
boundary condition: false
name: Biotin
constant: false
initial amount: NaN
is: C00120
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
boundary condition: false
name: methylglyoxal
type: Species
initial concentration: 1.0
is: HMDB01167
constant: false
initial amount: NaN
is: CHEBI:17158
has only substance units: false

metaR r1643
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
fast: false

metaM HC00591 m
has only substance units: false
boundary condition: false
name: 2-oxoglutaramate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16769
initial amount: NaN
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species

metaR r1434
name: Transport reaction
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction

metaM e4p c
is: CHEBI:16897
is: C00279
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01321
type: Species
boundary condition: false
name: D-Erythrose 4-phosphate
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279

metaR r0517
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110032#

metaR SUCD1m
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
product: MODEL1310110032#
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reactant: MODEL1310110032#
name: succinate dehydrogenase
type: Reaction
modifier: MODEL1310110032#
is described by: ECO:0000134
fast: false

metaR ACACtx
is described by: ECO:0000000
reactant: MODEL1310110032#
fast: false
name: acetoacetate intracellular transport unknown mechanism
is: SBO:0000185
product: MODEL1310110032#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110032#

metaM ksi deg14 l
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 14
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
reactant: MODEL1310110032#
fast: false
reversible: false
type: Reaction

metaR r2129
type: Reaction
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110032#

metaR GLCURtly
fast: false
modifier: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
type: Reaction
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000269
reversible: true
name: glucuronate transport into lysososme

metaM arachcrn m
constant: false
name: arachidyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
initial concentration: 1.0

metaR r0728
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is: SBO:0000176
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#

metaM spmd c
name: Spermidine
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01257
initial amount: NaN
initial concentration: 1.0
is: C00315
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
is: CHEBI:57834

metaM his L m
is: HMDB00177
constant: false
initial amount: NaN
is: CHEBI:15971
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_9bcfba2e_9e64_41c7_aa07_16a9a28b8840
name: GALNT6
type: Species
constant: false
initial amount: NaN
is: Q8NCL4
boundary condition: true
is encoded by: hsa:11226
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM glyc3p m
constant: false
boundary condition: false
is: CHEBI:57597
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
has only substance units: false
is: C00093
is: HMDB00126
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaM ppi c
has only substance units: false
name: Diphosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:0
is: C00013
type: Species
is: HMDB00250

metaR r1645
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110032#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0830
kinetic law: MODEL1310110032#
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false

metaR PA HSter
name: phosphatidate scramblase
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000185

metaM slfcys c
has only substance units: false
boundary condition: false
name: S-Sulfo-L-cysteine
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00731
is: C05824
initial concentration: 1.0
notes: FORMULA: C3H8NO5S2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110032#_b9137414_bafb_4b41_acea_2da6779456ec
initial concentration: NaN
initial amount: NaN
name: VNN3
is encoded by: hsa:55350
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM xyl D c
constant: false
initial concentration: 1.0
name: aldehydo-D-xylose
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15936

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM dopa e
is: HMDB00073
is: SBO:0000247
is: CHEBI:59905
has only substance units: false
boundary condition: false
type: Species
name: dopaminium(1+)
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
initial amount: NaN

metaR XYLTt
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
name: Xylitol transport via passive diffusion
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110032#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_58f04457_93d6_4391_868f_7a0d69b7cb10
constant: false
has only substance units: false
is encoded by: hsa:81031
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SLC2A10
type: Species
boundary condition: true
is: O95528

metaR r2341
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaM glyclt c
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
initial concentration: 1.0
constant: false
name: glycolate
is: CHEBI:29805
is: HMDB00115
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR HDCEAtr
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110032#
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110032#

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: false
type: Reaction
modifier: MODEL1310110032#
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reactant: MODEL1310110032#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3d25bee7_4078_4386_99ba_ff380dbe59d6
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NME1
is encoded by: hsa:4830
is: P15531
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_8b1d45a0_8f39_4560_b2b7_c00fc7850727
is: SBO:0000252
constant: false
is encoded by: hsa:4724
is: O43181
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: NDUFS4

metaM asn L e
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: CHEBI:17196
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00168
name: L-asparagine

metaR GGH 6DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM Asn X Ser Thr l
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00051
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938
is: C01342
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110032#_207dc902_8d1e_4ecf_93da_179304abbc2d
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ACSS2
is: Q5QPH3
has only substance units: false
boundary condition: true
is encoded by: hsa:55902

metaM nadh m
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
constant: false
is: HMDB01487
initial amount: NaN
is: CHEBI:57945
boundary condition: false
is: C00004
type: Species
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0

metaR r1644
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#

metaR LNLNCGt
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185

metaM prostgh2 e
is: CHEBI:57405
initial concentration: 1.0
type: Species
initial amount: NaN
name: prostaglandin H2(1-)
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
is: HMDB01381

http://identifiers.org/biomodels.db/MODEL1310110032#_5dce30f3_a68c_4c9a_baed_a26f485c5c62
initial amount: NaN
type: Species
name: ADA
constant: false
is: P00813
has only substance units: false
is encoded by: hsa:100
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM 3dsphgn c
initial amount: NaN
is: HMDB01480
is: CHEBI:58299
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
type: Species

metaM focytC m
name: Ferrocytochrome C
is: CHEBI:16928
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_aa2b45de_6964_41de_87b9_5f64df32b5c7
is: Q9UNP4
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8869
type: Species
initial concentration: NaN
name: ST3GAL5
initial amount: NaN

metaR VALTA
reactant: MODEL1310110032#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase

metaM 10fthf7glu e
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
is: HMDB00972
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: CHEBI:57454
initial amount: NaN

metaM ksi deg38 l
is: HMDB00143
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 38
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_9f3d8776_7b10_4012_a117_501be716adf0
type: Species
is encoded by: hsa:92745
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC38A5
boundary condition: true
has only substance units: false
is: Q8WUX1

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false
is: SBO:0000176

metaR r0683
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_c7da1c6b_e97d_46fd_98c8_cb5af6ec9d74
has only substance units: false
initial amount: NaN
name: DHODH
constant: false
is: Q02127
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1723
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_21c350e6_fbf6_4c86_bb7d_bd26348a3d5a
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI640625
name: _AI640625_1_c
type: Species
is: SBO:0000252
has only substance units: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_215c0ebf_96b6_4c36_9220_b3b39665c10c
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3550
initial concentration: NaN
is: Q13123
name: IK
has only substance units: false
boundary condition: true
type: Species

metaM spmd e
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57834
initial concentration: 1.0
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial amount: NaN
constant: false
is: HMDB01257
name: Spermidine
is: SBO:0000247
is: C00315

metaR r0002
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
is described by: ECO:0000000

metaR r0726
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110032#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
product: MODEL1310110032#

metaR r1579
reversible: true
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110032#
is described by: ECO:0000000

metaR r1647
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110032#

metaR GGH 5THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
name: Gamma-glutamyl hydrolase (5THF), extracellular
kinetic law: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#

metaR r2054
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000

metaM slfcys e
is: C05824
initial amount: NaN
name: S-Sulfo-L-cysteine
is: SBO:0000247
notes: FORMULA: C3H8NO5S2 CHARGE: -1
type: Species
constant: false
boundary condition: false
has only substance units: false
is: HMDB00731
initial concentration: 1.0

metaR AHCYStd
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:

metaM ppi e
is: SBO:0000247
name: Diphosphate
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:33019
initial amount: NaN
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110032#_f5941e47_cb0a_454a_acc5_d3abb96f9303
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
is: SBO:0000252
constant: false
type: Species
name: HK1
has only substance units: false
is: Q59FD4

metaM dopa c
name: dopaminium(1+)
is: HMDB00073
type: Species
constant: false
initial amount: NaN
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM xyl D e
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:15936
name: aldehydo-D-xylose

metaR r0680
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110032#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176

metaM man1p c
has only substance units: false
boundary condition: false
is: HMDB06330
type: Species
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
name: D-Mannose 1-phosphate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:35374

http://identifiers.org/biomodels.db/MODEL1310110032#_86dcc3b7_e015_4bea_a8a7_c36c28d45414
is: SBO:0000252
has only substance units: false
is: P47895
constant: false
name: ALDH1A3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:220
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_956ff64c_1574_42a9_8bcc_97618776996f
constant: false
type: Species
name: ACHE
is encoded by: hsa:43
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM dhcholestancoa x
is: SBO:0000247
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02159
is: CHEBI:15494
has only substance units: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
constant: false

metaR r1646
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reversible: true
fast: false

metaR DHORTS
fast: false
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
product: MODEL1310110032#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
kinetic law: MODEL1310110032#
is described by: ECO:0000269
modifier: MODEL1310110032#
reactant: MODEL1310110032#
name: dihydroorotase
type: Reaction

metaR 2HBO
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reactant: MODEL1310110032#
fast: false

metaR GTHO
name: glutathione oxidoreductase
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is: SBO:0000176
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110032#

metaM prostgh2 c
is: SBO:0000247
boundary condition: false
name: prostaglandin H2(1-)
constant: false
initial amount: NaN
is: CHEBI:57405
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_344b8571_9aed_4077_a190_874dd9af4871
initial concentration: NaN
name: NDUFV1
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4723
is: SBO:0000252
is: E5KNH5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_2cbe1b91_ef25_4b1f_b3e0_d1f49af2892f
boundary condition: true
has only substance units: false
initial concentration: NaN
name: NT5C3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51251
type: Species
constant: false
is: Q9H0P0

metaM HC02207 e
has only substance units: false
is: CHEBI:27555
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
name: prostaglandin-c2
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_9f6278ba_06b7_47d1_983e_8c8f486afdee
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:767
is: SBO:0000252
name: CA8
type: Species
has only substance units: false
boundary condition: true
is: P35219

metaR r2344
type: Reaction
fast: false
reactant: MODEL1310110032#
reversible: true
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110032#

metaR r0086
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.1.3
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:

metaR r0834
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
product: MODEL1310110032#

metaR r0686
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110032#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

metaR GTHP
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reactant: MODEL1310110032#
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false

metaM accoa x
name: Acetyl-CoA
is: CHEBI:57288
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: HMDB01206
constant: false

metaR TAGt
reversible: true
name: triacylglycerol transport
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_85f3cd8e_92b3_4820_8bc3_3d327993ff8d
has only substance units: false
name: OCRL
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4952
constant: false
is: Q01968
initial amount: NaN
type: Species

metaR r0724
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/2.7.1.33
fast: false

metaR RE3556C
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000176
name: RE3556
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110032#

metaR r1649
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110032#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_48fdbeff_a4dc_4f91_a4fd_89e808813372
is encoded by: hsa:115286
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC25A26
initial amount: NaN
type: Species
is: F8WAB8
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_bfcaef1f_4a46_4905_82ce_ed3d59664343
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:131669
is: Q68CJ7
has only substance units: false
type: Species
name: UROC1

metaM icit c
is: HMDB00193
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16087
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
initial amount: NaN
constant: false

metaM btcoa m
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: C00136
is: CHEBI:57371
is: SBO:0000247
is: HMDB01088
initial concentration: 1.0
has only substance units: false
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaR RE3524R
reversible: true
kinetic law: MODEL1310110032#
name: RE3524
fast: false
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000

metaR LTD4DP
reactant: MODEL1310110032#
name: Leukotriene D4 dipeptidase
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176

metaM nadh r
is: SBO:0000247
is: CHEBI:57945
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
boundary condition: false
has only substance units: false
type: Species
name: NADH(2-)
initial concentration: 1.0
initial amount: NaN
constant: false

metaR GLYCLTtp
kinetic law: MODEL1310110032#
reversible: false
product: MODEL1310110032#
reactant: MODEL1310110032#
name: glycolate transport into peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
fast: false
type: Reaction

metaR r2131
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM mal L x
is: HMDB00156
constant: false
name: (S)-malate(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaR r0085
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110032#_8c4b0ce1_bbeb_4b03_81d2_a4163d78742f
is: P23919
constant: false
is encoded by: hsa:1841
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: DTYMK
boundary condition: true
initial amount: NaN

metaM HC00591 c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16769
constant: false
is: SBO:0000247
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_164c87a0_aa03_4cca_9739_b6c2897ad760
name: PLCD1
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5333
initial concentration: NaN
is: P51178
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_1c4e124c_20e6_4f35_a602_9ad647d2563b
initial concentration: NaN
boundary condition: true
name: SLC26A1
has only substance units: false
initial amount: NaN
is encoded by: hsa:10861
is: SBO:0000252
constant: false
type: Species

metaM oagd3 hs e
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02168
is: SBO:0000247
name: 9-O-Acetylated GD3
constant: false
is: CHEBI:18421
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial concentration: 1.0

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
type: Reaction
product: MODEL1310110032#
reversible: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110032#

metaM rib D c
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
is: HMDB00283
name: D-ribose
is: CHEBI:16988

metaR r1578
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110032#
type: Reaction

metaR r1831
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110032#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#

metaR r1648
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_43aa2fa2_fe5d_46fc_9629_4d7a74a3cd2a
constant: false
is: SBO:0000252
is encoded by: hsa:27068
has only substance units: false
is: Q9H2U2
name: PPA2
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_da53a2e5_7088_486b_b6bf_966092bc2af5
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5471
is: Q06203
has only substance units: false
name: PPAT

metaR r0009
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110032#
is described by: ECO:0000000
modifier: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
product: MODEL1310110032#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
type: Reaction
kinetic law: MODEL1310110032#

metaM utp e
is: HMDB00285
initial amount: NaN
has only substance units: false
is: CHEBI:46398
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: UTP(4-)
constant: false
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

http://identifiers.org/biomodels.db/MODEL1310110032#_c3608979_5732_4913_a064_87af4c093a63
initial concentration: NaN
is: P30519
boundary condition: true
type: Species
name: HMOX2
is: SBO:0000252
constant: false
is encoded by: hsa:3163
initial amount: NaN
has only substance units: false

metaR r0835
reactant: MODEL1310110032#
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR r2346
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110032#

metaM tdchola e
is: CHEBI:9407
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: taurochenodeoxycholate
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
is: HMDB00951
initial concentration: 1.0

metaM CE2838 e
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial amount: NaN
constant: false
is: C01936
is: SBO:0000247
type: Species
name: maltononaose
is: http://identifiers.org/pubchem.compound/5041

metaR NDPK2n
product: MODEL1310110032#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110032#

metaR r2132
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR ITPtn
is: SBO:0000185
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
fast: false

metaM s2l2n2m2mn l
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57312
is: HMDB01356
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
is: SBO:0000247
notes: FORMULA: C76H123N5O57 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110032#_2bf770a3_7742_496c_a335_808aaff803c9
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI971036
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: _AI971036_1_c

http://identifiers.org/biomodels.db/MODEL1310110032#_1cff0341_5479_491e_8544_92af00fc7977
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaM HC02207 c
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:27555
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-c2
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57312
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01356
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_25103834_d5e4_455f_87bd_c30ef38b7a75
type: Species
constant: false
is: Q9P019
boundary condition: true
name: PHPT1
is encoded by: hsa:29085
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM pail45p hs c
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
has only substance units: false
constant: false
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
type: Species
is: SBO:0000247
initial amount: NaN

metaM acmana r
name: N-acetyl-D-mannosamine
boundary condition: false
is: SBO:0000247
is: CHEBI:17122
type: Species
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01129

metaR r2058
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0722
kinetic law: MODEL1310110032#
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
product: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
modifier: MODEL1310110032#
fast: false

metaR MALTt1r
name: maltose transport (uniport)
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000185

metaR r1575
is described by: ECO:0000000
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
fast: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR r0836
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
reversible: true
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185

metaR r2347
reversible: true
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110032#
product: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_b31fc37d_29e3_451b_91fc_3a2afa02fdd1
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AA177072
constant: false
initial concentration: NaN
name: _AA177072_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_ad9d573b_5641_40de_bad6_e312e01009ae
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6549
has only substance units: false
is: Q9UBY0
name: SLC9A2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_b60d30b0_47cf_46b0_bec4_d2f397c14b7d
constant: false
has only substance units: false
name: RBAK
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57786
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NYW8

metaR r0083
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reactant: MODEL1310110032#
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_94bc825b_222a_4f06_b603_6fce4b953d54
type: Species
initial concentration: NaN
name: LPL
constant: false
is: SBO:0000252
is encoded by: hsa:4023
initial amount: NaN
boundary condition: true
is: P06858
has only substance units: false

metaR r2133
product: MODEL1310110032#
modifier: MODEL1310110032#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110032#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110032#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_b3697f4f_f9d4_4495_bacb_73b466ca09ad
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q7LG56
type: Species
name: RRM2B
has only substance units: false
boundary condition: true
is encoded by: hsa:50484

metaM trp L e
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16828
name: L-tryptophan
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM fadh2 c
is: HMDB01197
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:58307
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0

metaM oagd3 hs g
name: 9-O-Acetylated GD3
is: C00029
is: CHEBI:58367
type: Species
is: HMDB00286
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_5e33d81f_d2ab_428d_ba9b_8014a549069f
initial amount: NaN
boundary condition: true
name: ALDH3B2
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P48448
is encoded by: hsa:222
constant: false

metaR HISD
type: Reaction
name: histidase
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.3.1.3
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is described by: ECO:0000269
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110032#

metaM rib D e
has only substance units: false
is: HMDB00283
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
name: D-ribose
constant: false
is: SBO:0000247

metaR r1576
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_85f64058_5ce9_436e_b012_013b363f1e80
type: Species
constant: false
has only substance units: false
is encoded by: hsa:125061
name: AFMID
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q63HM1
initial concentration: NaN

metaR NCAMUP
fast: false
name: Nicotinamide acid uptake
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
reactant: MODEL1310110032#
type: Reaction

metaM tdchola c
has only substance units: false
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00951
name: taurochenodeoxycholate
boundary condition: false
initial concentration: 1.0

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:17196
initial amount: NaN
constant: false
name: L-asparagine
type: Species
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110032#_9f83020e_6580_447d_83b1_a322edbe0739
has only substance units: false
name: CHAT
initial concentration: NaN
constant: false
is encoded by: hsa:1103
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q6LEN6

http://identifiers.org/biomodels.db/MODEL1310110032#_b2b3e410_0dcb_4af0_a572_b15ba18a107b
initial concentration: NaN
is encoded by: hsa:57127
is: SBO:0000252
constant: false
has only substance units: false
is: Q9H310
boundary condition: true
initial amount: NaN
name: RHBG
type: Species

metaR RE1898C
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1898
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_301bb1c3_39c9_4920_b33d_6d78513e4476
constant: false
is: SBO:0000252
type: Species
name: _HG2846_HT2983_1_c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
boundary condition: true

metaR 3AIB Dtm
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000134
fast: false
reversible: true
product: MODEL1310110032#
type: Reaction
name: transport of 3aib_D into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
is: SBO:0000185

metaM 56dthm c
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00079
is: CHEBI:27468
constant: false
has only substance units: false
initial amount: NaN
name: 5,6-dihydrothymine

http://identifiers.org/biomodels.db/MODEL1310110032#_1e18baa5_e025_4f2d_ad38_9746794d4259
has only substance units: false
type: Species
is encoded by: hsa:6515
initial concentration: NaN
is: P11169
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_3417dab9_d025_49a6_9e27_11e92612011f
name: NDUFB1
type: Species
is encoded by: hsa:4707
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O75438

http://identifiers.org/biomodels.db/MODEL1310110032#_745df562_fd7b_4c63_8d3c_91f270234f4c
is encoded by: hsa:AI091231
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: _AI091231_1_c

metaM HC01399 m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
has only substance units: false
constant: false
type: Species
name: (S)-3-Hydroxytetradecanoyl-CoA
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:27466

metaR r1573
is described by: ECO:0000000
reversible: true
product: MODEL1310110032#
fast: false
is: SBO:0000185
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_17814ec2_c58d_4050_abf3_aa69c1bc62aa
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CDIPT
initial concentration: NaN
constant: false
has only substance units: false
is: A8K3L7
type: Species
is encoded by: hsa:10423

http://identifiers.org/biomodels.db/MODEL1310110032#_7eed01d9_b394_4bbb_9d69_6b3e1e791d04
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7991
is: Q13454
initial concentration: NaN
name: TUSC3
boundary condition: true

metaM trp L c
is: HMDB00929
is: CHEBI:16828
name: L-tryptophan
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM gmp g
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: HMDB01397
initial amount: NaN
boundary condition: false
is: CHEBI:58115
name: GMP(3-)

http://identifiers.org/biomodels.db/MODEL1310110032#_38463bc3_b4a0_46ad_885b_d63251396f72
has only substance units: false
is encoded by: hsa:4709
initial amount: NaN
constant: false
is: SBO:0000252
name: NDUFB3
initial concentration: NaN
type: Species
is: Q6IB80
boundary condition: true

metaR OCOAT1m
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.8.3.5
is: SBO:0000176
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
name: 3-oxoacid CoA-transferase
type: Reaction

metaR r1834
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0720
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reversible: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR r1109
product: MODEL1310110032#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_df03f546_87ec_4927_9fdf_a435c71033b6
boundary condition: true
name: CLYBL
constant: false
type: Species
is encoded by: hsa:171425
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q8N0X4

http://identifiers.org/biomodels.db/MODEL1310110032#_40376aa6_35d7_47e1_82d8_9832db1dc87d
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P04066
name: FUCA1
boundary condition: true
is encoded by: hsa:2517

metaM etfrd m
is: CHEBI:57312
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: RH2 CHARGE: 0
is: HMDB01356
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: Electron transfer flavoprotein reduced

metaM pail34p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57658
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110032#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_360d8d02_790b_4b33_9ced_ef47a8cc9c49
is: O75191
initial concentration: NaN
name: XYLB
is: SBO:0000252
is encoded by: hsa:9942
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR DOPASFt
name: Dopamine 3-0-sulfate transport (diffusion)
is described by: ECO:0000000
fast: false
reactant: MODEL1310110032#
reversible: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
type: Reaction
is: SBO:0000185
product: MODEL1310110032#

metaM 56dthm m
is: HMDB00079
is: CHEBI:27468
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
type: Species
name: 5,6-dihydrothymine
boundary condition: false

metaR S2L2N2M2MASNtly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
name: s2l2n2m2masn transport, extracellular to lysosome
reversible: false
fast: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_2941ba76_587f_4bff_93c6_c31a0963fce3
constant: false
name: PGM3
is: B4DX94
initial concentration: NaN
type: Species
is encoded by: hsa:5238
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM crm hs e
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
constant: false
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM inost c
constant: false
name: myo-inositol
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
is: CHEBI:17268
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR GGH 10FTHF6GLUe
product: MODEL1310110032#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is described by: ECO:0000000
fast: false

metaM mal L m
is: SBO:0000247
type: Species
is: HMDB00156
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15589
has only substance units: false
name: (S)-malate(2-)
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false

metaR FAOXC180
product: MODEL1310110032#
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110032#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_c19734f9_dfab_4fb6_b00a_1fc4759958ed
has only substance units: false
is: B7Z6M3
boundary condition: true
is encoded by: hsa:8525
initial amount: NaN
is: SBO:0000252
name: DGKZ
type: Species
constant: false
initial concentration: NaN

metaR r1988
reactant: MODEL1310110032#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110032#

metaR r0944
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#
product: MODEL1310110032#
name: Active transport
reversible: true

metaM asn L m
has only substance units: false
initial amount: NaN
name: L-asparagine
type: Species
initial concentration: 1.0
constant: false
is: HMDB00168
is: CHEBI:17196
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false

metaR XAOx
product: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
name: xanthine oxidase,peroxisomal
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:IT (1.17.3.2)
type: Reaction

metaR r0578
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27

metaR A MANASEly
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: alpha-mannosidase, lysosomal
fast: false
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false

metaR r0614
reversible: true
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110032#
type: Reaction
reactant: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is: SBO:0000176
fast: false

metaM 34hpp c
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: SBO:0000247
is: CHEBI:36242
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR r1571
reversible: true
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM oagd3 hs c
name: 9-O-Acetylated GD3
has only substance units: false
is: HMDB00286
constant: false
boundary condition: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: C00029
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58367

metaR MI1345PP
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110032#
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110032#
is: SBO:0000176
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7bbf8121_c9c7_4477_97b3_b232a7aa331e
has only substance units: false
initial concentration: NaN
name: _R33828_1_c
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:R33828
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_4d1f9538_28ed_4fee_8dd0_518b8ea330f8
type: Species
has only substance units: false
initial amount: NaN
name: NADSYN1
is: Q6IA69
is encoded by: hsa:55191
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_159ac4bd_7492_4359_93d7_9e26e76b4d1e
is: Q99643
name: SDHC
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6391

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM acmana e
is: HMDB01129
is: CHEBI:17122
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
type: Species
constant: false
initial concentration: 1.0
name: N-acetyl-D-mannosamine
boundary condition: false
has only substance units: false

metaM dcsptn1crn m
initial concentration: 1.0
type: Species
is: HMDB06321
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_bfad62d3_f38f_401e_8f00_c385768a76f5
is encoded by: hsa:4714
constant: false
initial concentration: NaN
boundary condition: true
is: O95169
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFB8

metaR r1836
product: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false

metaM acetol c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: hydroxyacetone
is: CHEBI:27957
is: HMDB06961
constant: false
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3

metaM lald D c
is: HMDB06458
initial concentration: 1.0
type: Species
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17167
constant: false

metaR r0575
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110032#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaR LDH L
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaM pram c
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial concentration: 1.0
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
constant: false
is: CHEBI:58681
is: HMDB01128
boundary condition: false
has only substance units: false
type: Species
is: C03090
is: SBO:0000247

metaM pmtcrn c
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17490
boundary condition: false
is: HMDB00222
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_d25b6b2a_8f32_491c_8083_dcc2fc852894
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
type: Species
name: PRDX2
is: P32119

metaR PI45P5Pn
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
type: Reaction
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_f1ec3490_f029_459a_b43c_d21a068ff531
is: E9PCI1
type: Species
is encoded by: hsa:53
is: SBO:0000252
constant: false
has only substance units: false
name: ACP2
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r0946
is described by: ECO:0000000
reactant: MODEL1310110032#
is: SBO:0000185
product: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
fast: false
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r1837
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110032#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110032#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110032#_5d200e16_e1b6_44fa_b2ba_d0133e3fc716
type: Species
has only substance units: false
is: SBO:0000252
name: MTHFD1L
initial amount: NaN
is: B2RD24
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:25902

http://identifiers.org/biomodels.db/MODEL1310110032#_c56488bc_92d7_42c0_94c5_8d2b678c9c5b
initial amount: NaN
has only substance units: false
name: _U37519_1_e
is encoded by: hsa:U37519
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM HC01496 m
is: CHEBI:28095
has only substance units: false
type: Species
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 2-Amino-3-oxoadipate
is: SBO:0000247

metaM utp c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
constant: false
boundary condition: false
type: Species
name: UTP
is: HMDB00285
initial amount: NaN
is: CHEBI:46398
is: SBO:0000247

metaM g1p c
is: C00103
is: HMDB01586
constant: false
boundary condition: false
name: D-Glucose 1-phosphate
is: CHEBI:58601
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_85e39a93_7638_41ad_ab9e_e334ebb468c9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: SLC35A1
is: P78382
has only substance units: false
is encoded by: hsa:10559

metaM crm hs g
initial amount: NaN
constant: false
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaR PI45P5P
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110032#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.3.36

http://identifiers.org/biomodels.db/MODEL1310110032#_6b7366f4_5d16_4c91_ba16_c288944993ae
is: Q0VAA5
initial amount: NaN
is encoded by: hsa:257068
name: PLCXD2
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM bhb c
name: (R)-3-hydroxybutyrate
type: Species
is: HMDB00011
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaM inost e
is: HMDB00211
is: SBO:0000247
name: myo-inositol
initial amount: NaN
boundary condition: false
is: CHEBI:17268
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_f365dce4_1c79_46c5_ab94_cc1136ef1ff5
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P45954
is encoded by: hsa:36
boundary condition: true
name: ACADSB
initial concentration: NaN
constant: false

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Glycerol 3-phosphate
type: Species
is: C00093
is: HMDB00126
boundary condition: false
is: CHEBI:57597

metaR FE3R2e
type: Reaction
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110032#
name: Fe(III) reduction (ascorbate)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD

metaR NACASPAH
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
is version of: http://identifiers.org/ec-code/3.5.1.15
kinetic law: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#
modifier: MODEL1310110032#
name: N-Acetyl-L-aspartate amidohydrolase
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_138a2bea_2d8f_49c7_b766_7c9455d50518
is: SBO:0000252
initial concentration: NaN
is: O95470
type: Species
initial amount: NaN
boundary condition: true
name: SGPL1
has only substance units: false
constant: false
is encoded by: hsa:8879

metaM pristcoa c
is: CHEBI:51341
name: pristanoyl coa
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false

metaM 34hpp e
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_c0ab29b2_8c0c_4194_9089_56e675ccfd8e
is encoded by: hsa:3030
initial concentration: NaN
has only substance units: false
is: E9KL44
boundary condition: true
type: Species
is: SBO:0000252
name: HADHA
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_dba202d4_3b7d_4774_b5a9_3ff3e8c169d0
name: AGXT2L1
is: Q8TBG4
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64850
initial concentration: NaN
has only substance units: false
type: Species

metaM pail45p hs m
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
type: Species
boundary condition: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR Htg
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
fast: false
name: proton diffusion (Golgi)
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction

metaR PAFHe
is: SBO:0000176
name: Platelet-activating factor acetylhydrolase
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.1.47
reactant: MODEL1310110032#
product: MODEL1310110032#

metaM nac c
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:0
is: C00253
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
name: Nicotinate
is: HMDB01488
initial amount: NaN
initial concentration: 1.0

metaR DNDPt37m
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: dUTP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110032#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_be575f84_f677_410c_bdb8_14825bdb0aa4
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4522
is: P11586
initial amount: NaN
type: Species
name: MTHFD1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_df46c5e7_4bcc_4bad_949d_851f5aa81667
is: O95045
initial amount: NaN
type: Species
boundary condition: true
name: UPP2
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:151531

metaR FATP1t
kinetic law: MODEL1310110032#
reversible: true
fast: false
name: fatty acid electroneutral transport
is described by: ECO:0000269
type: Reaction
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000185

metaM chol e
is: SBO:0000247
is: HMDB00097
initial amount: NaN
name: Choline
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
is: CHEBI:15354
type: Species
initial concentration: 1.0

metaR r1088
name: Active transport
type: Reaction
reversible: true
reactant: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR MMEm
type: Reaction
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
reversible: true
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaM oxa e
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:30623
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
name: oxalate(2-)
initial concentration: 1.0
type: Species
has only substance units: false

metaR RETHe
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
name: retinyl ester hydrolase, extracellular
is described by: ECO:0000000

metaR r1570
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110032#
product: MODEL1310110032#

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
name: K+-Cl- cotransporter (NH4+)
type: Reaction

metaR RE3626M
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reversible: false
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110032#
type: Reaction

metaM hdcea e
name: Hexadecenoate (n-C16:1)
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB03229
boundary condition: false
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is: SBO:0000176
name: glycerol-3-phosphate dehydrogenase (NAD)
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
type: Reaction

metaR r1106
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
product: MODEL1310110032#
reactant: MODEL1310110032#
reversible: true
name: Postulated transport reaction

metaR r0940
kinetic law: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110032#_c2172eea_f415_4160_87e0_0fb33d3d9c3c
initial amount: NaN
initial concentration: NaN
constant: false
name: NMNAT2
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23057
has only substance units: false

metaR r0618
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
reversible: true
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110032#

metaR CLOHtex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110032#
is described by: ECO:0000304
kinetic law: MODEL1310110032#
reversible: false
name: chloride transport via hydroxide countertransport (2:1)
is: SBO:0000185
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false

metaM nadh x
type: Species
is: CHEBI:57945
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
constant: false
boundary condition: false
is: HMDB01487
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00004

metaR PRODt2r
is described by: ECO:0000304
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
fast: false
kinetic law: MODEL1310110032#
name: D-proline reversible transport via proton symport
modifier: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110032#_8895e684_2b27_42c2_aa98_e111059d0348
is encoded by: hsa:4831
initial concentration: NaN
type: Species
name: NME1:NME2
is: SBO:0000297
initial amount: NaN
boundary condition: true
has part: P15531
has only substance units: false
has part: P22392
is encoded by: hsa:4830
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_c256d859_1a63_440d_9fa8_58b1a8c6445d
is: Q9NQ66
name: PLCB1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:23236
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_d9a739d0_ae99_4aea_aa67_d480b9645456
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AU149534_1_m
is encoded by: hsa:AU149534
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM lnlncgcoa r
type: Species
is: CHEBI:57363
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
constant: false
is: HMDB06368
initial concentration: 1.0
initial amount: NaN

metaM accoa m
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00024
initial amount: NaN
is: HMDB01206
is: CHEBI:57288
boundary condition: false
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM 2oxoadp m
is: SBO:0000247
type: Species
is: CHEBI:57499
is: HMDB00225
boundary condition: false
initial concentration: 1.0
name: 2-oxoadipate(2-)
constant: false
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_322f7c02_070e_42a7_b21f_ce8a40077712
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4722
has only substance units: false
is: O75489
constant: false
name: NDUFS3
type: Species
initial concentration: NaN
boundary condition: true

metaM nac e
name: Nicotinate
is: CHEBI:0
is: C00253
is: SBO:0000247
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01488
initial concentration: 1.0
has only substance units: false

metaM hdcea c
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
is: HMDB03229
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
initial amount: NaN
initial concentration: 1.0

metaR r0941
reversible: true
type: Reaction
reactant: MODEL1310110032#
name: Free diffusion
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_519a0d24_d12e_42fb_9358_224afbdf0d38
has only substance units: false
type: Species
initial concentration: NaN
name: SLC9A3
boundary condition: true
initial amount: NaN
constant: false
is: P48764
is encoded by: hsa:6550
is: SBO:0000252

metaM icit m
has only substance units: false
type: Species
initial concentration: 1.0
is: C00311
is: HMDB00193
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16087
name: Isocitrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

http://identifiers.org/biomodels.db/MODEL1310110032#_34f2e202_2262_44ad_8bd5_421847f4ab05
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4538
is: SBO:0000252
name: ND4
type: Species
initial amount: NaN
is: P03905

http://identifiers.org/biomodels.db/MODEL1310110032#_38c3a868_29e2_49f7_87a6_b0af81e521b2
initial amount: NaN
has only substance units: false
is: Q8TCG5
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:126129
initial concentration: NaN
name: CPT1C

metaM mi1345p c
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: CHEBI:57895
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: HMDB01059
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_0e843cbf_948b_4f97_818f_e01276e749c9
initial amount: NaN
is: P22413
initial concentration: NaN
name: ENPP1
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5167
type: Species

metaM oxa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
initial concentration: 1.0
type: Species
is: HMDB02329
boundary condition: false
name: oxalate(2-)
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_cbbd7fd6_89c6_4011_bb66_099a46d7a84d
name: SLC5A12
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:159963
is: Q1EHB4
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR BAAT4x
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
fast: false

metaM chol c
is: C00114
is: HMDB00097
is: SBO:0000247
initial amount: NaN
name: Choline
boundary condition: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: CHEBI:15354
type: Species
initial concentration: 1.0

metaM 13 cis retn r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/7847414
constant: false
has only substance units: false
is: HMDB06219
boundary condition: false
is: D00348
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952

http://identifiers.org/biomodels.db/MODEL1310110032#_bb3d987c_9275_415a_a3e4_e5dba4ea0a76
is encoded by: hsa:28976
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9H845
type: Species
initial concentration: NaN
name: ACAD9
constant: false
has only substance units: false

metaM HC01434 m
type: Species
is: CHEBI:58931
has only substance units: false
boundary condition: false
name: oxalatosuccinate(3-)
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110032#_fcb97d2a_eeac_40e0_9b19_09b9078e94ca
type: Species
is encoded by: hsa:492
has only substance units: false
name: ATP2B3
initial amount: NaN
boundary condition: true
is: Q16720
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_4cdbff9c_d393_4855_ae44_45abc08f489b
has only substance units: false
is encoded by: hsa:U52111
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _U52111_1_c

metaM accoa n
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
is: CHEBI:57288
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01206
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_eda87fd2_fa82_4e55_abf4_b4cf965da229
is encoded by: hsa:56606
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC2A9
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR HEXDICOAACBPx
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR APAT2rm
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reversible: true
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.6.1.19

metaM crm hs c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:52639
boundary condition: false
constant: false
name: N-acylsphingosine

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
product: MODEL1310110032#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0942
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
product: MODEL1310110032#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_23a5ad83_d332_410f_9fbf_610474cc15f5
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SGPP2
is encoded by: hsa:130367
type: Species
is: Q8IWX5

metaR r1986
modifier: MODEL1310110032#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000185

metaM pail45p hs n
has only substance units: false
type: Species
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28910
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0

metaR r0616
reactant: MODEL1310110032#
type: Reaction
fast: false
kinetic law: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
modifier: MODEL1310110032#
is: SBO:0000176
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_7538948b_68a7_4317_9fe9_408c1744d119
name: DGUOK
initial amount: NaN
is encoded by: hsa:1716
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E5KSL6
constant: false
boundary condition: true

metaR ABTti
reversible: false
type: Reaction
is described by: ECO:0000000
name: L-arabinitol transport via passive diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
reactant: MODEL1310110032#

metaM lnlccrn m
is: SBO:0000247
constant: false
name: Linoleyl carnitine
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
is: HMDB06469
initial concentration: 1.0

metaR H2O2t
fast: false
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110032#
name: hydrogen peroxide transport via diffusion
product: MODEL1310110032#
is: SBO:0000185
reversible: true

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR MI14P4P
fast: false
name: inositol-1,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110032#
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_db1c1642_4704_45d9_95ad_1841c3004f0d
type: Species
is: Q9NY28
name: GALNT8
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26290
constant: false
initial concentration: NaN

metaR r0245
product: MODEL1310110032#
type: Reaction
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
is described by: ECO:0000000
reactant: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
product: MODEL1310110032#
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110032#

metaM fol m
constant: false
initial concentration: 1.0
name: Folate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: CHEBI:27470
has only substance units: false
type: Species
boundary condition: false
is: HMDB00121

metaR GGH 7THFe
reactant: MODEL1310110032#
name: Gamma-glutamyl hydrolase (7THF), extracellular
is described by: ECO:0000000
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reversible: false
product: MODEL1310110032#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_fcb69716_ab9b_4d5a_82ee_adec94111d64
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: TXNRD1
type: Species

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR PMTCOAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110032#
product: MODEL1310110032#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110032#
reversible: true

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
name: ornithine mitochondrial transport via proton antiport
type: Reaction
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110032#
kinetic law: MODEL1310110032#

metaM glysar c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/93131
notes: FORMULA: C5H10N2O3 CHARGE: 0
constant: false
initial amount: NaN
name: Glycylsarcosine
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_5521a110_b32b_4b88_b336_a719ea67fd24
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q9Y2Q0
name: ATP8A1
is encoded by: hsa:10396
is: SBO:0000252
initial concentration: NaN

metaM lnlncgcoa m
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
is: CHEBI:57363
boundary condition: false
type: Species

metaM ura c
has only substance units: false
boundary condition: false
is: HMDB00300
initial amount: NaN
is: CHEBI:17568
is: C00106
constant: false
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
is: SBO:0000247
name: Uracil

http://identifiers.org/biomodels.db/MODEL1310110032#_8b5aacf1_22ba_4d83_9e25_336dbf1268b3
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AU149534_1_c
is: SBO:0000252
is encoded by: hsa:AU149534
constant: false
initial amount: NaN

metaM dutp m
initial concentration: 1.0
is: CHEBI:17625
has only substance units: false
constant: false
type: Species
boundary condition: false
name: dUTP
initial amount: NaN
is: HMDB01191
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

http://identifiers.org/biomodels.db/MODEL1310110032#_a2aee06c_7bb1_48ec_8e84_2c384da7bdc9
constant: false
name: HADHA
is: E9KL44
is: SBO:0000252
is encoded by: hsa:3030
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_105d4874_17d1_4b9b_ab12_090f88c9e3b4
initial concentration: NaN
is: Q9UFY1
constant: false
is: SBO:0000252
is encoded by: hsa:5335
name: PLCG1
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaM nrpphrsf c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02062
name: Sulfate derivative of norepinephrine
has only substance units: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN

metaM s2l2n2m2masn l
name: de-Fuc form of PA6
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB00174
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: CHEBI:18287
constant: false
is: SBO:0000247
initial amount: NaN

metaM arachdcoa m
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: arachidonoyl-CoA(4-)
is: HMDB06523
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r2472
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.4.7
type: Reaction
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reversible: false
is: SBO:0000185

metaM HC02205 e
is: CHEBI:28099
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
initial amount: NaN
name: prostaglandin-b2
initial concentration: 1.0

metaR ARACHt
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110032#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110032#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_580e953b_98f5_4ed7_bedf_c4ee665cac1b
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: HLCS
is: SBO:0000252
is encoded by: hsa:3141
boundary condition: true
type: Species
is: P50747

http://identifiers.org/biomodels.db/MODEL1310110032#_e950a191_422f_4ddb_a0a6_f0029ac75e19
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:8613
name: PPAP2B
is: O14495
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM 25aics c
has only substance units: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: CHEBI:58443
initial amount: NaN
constant: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: SBO:0000247
type: Species
boundary condition: false
is: C04823
initial concentration: 1.0
is: HMDB00797

metaM dutp n
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17625
is: SBO:0000247
is: HMDB01191
boundary condition: false
name: dUTP
constant: false

metaM dhcrm hs c
is: CHEBI:31488
initial concentration: 1.0
boundary condition: false
constant: false
name: dihydroceramide
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_4813801a_3c87_440f_b626_d990185d0c6a
name: CTPS1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P17812
is encoded by: hsa:1503
type: Species
boundary condition: true
has only substance units: false

metaR ACALDt
is: SBO:0000185
fast: false
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000000
name: acetaldehyde reversible transport
type: Reaction
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM Ser Thr g
initial amount: NaN
type: Species
is: HMDB00645
boundary condition: false
is: CHEBI:58336
constant: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)

http://identifiers.org/biomodels.db/MODEL1310110032#_25634e71_b6f7_43c9_951f_9f477fe8ea1d
is: SBO:0000252
constant: false
is encoded by: hsa:2523
is: Q6IZA2
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: FUT1
type: Species

metaM 1p3h5c m
is: SBO:0000247
type: Species
is: CHEBI:6151
is: HMDB01369
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate

metaR r2471
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false

metaM ppi r
is: SBO:0000247
is: CHEBI:33019
is: C00013
initial amount: NaN
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
has only substance units: false
type: Species
name: Diphosphate
is: HMDB00250
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_ad27bac5_b7fd_4709_b9e3_b94be35f64c7
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: MUT
is encoded by: hsa:4594
is: SBO:0000252
constant: false
is: P22033

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR NCKt
modifier: MODEL1310110032#
is described by: ECO:0000269
kinetic law: MODEL1310110032#
reversible: true
reactant: MODEL1310110032#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_0e77d168_21c5_4ae3_a7fa_be31b890557a
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
name: UROD
is: P06132
initial concentration: NaN
is encoded by: hsa:7389
is: SBO:0000252

metaM arachcoa m
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB04258
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
boundary condition: false
name: arachidyl coenzyme A
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_bc8af14c_03ae_4615_a588_5faf9d7234da
is encoded by: hsa:10993
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SDS
boundary condition: true
is: P20132
initial concentration: NaN

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_a184a721_1406_4ba9_a98f_7deec54ad103
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GMPPA
has only substance units: false
constant: false
is encoded by: hsa:29926
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_44ef7dc8_d38b_45e0_8f30_8fb4d51182d5
is: A8K4A0
name: ARSB
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:411
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_727711e9_ea25_4f5d_a5a6_3473d0a3eb84
is: Q9NTN3
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:23169
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC35D1

http://identifiers.org/biomodels.db/MODEL1310110032#_d2d41213_d8b5_4c92_b6a8_cc16264ee541
is: P33121
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2180
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACSL1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_cec37d39_73de_4ba6_924c_9de218765a58
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:957
boundary condition: true
initial amount: NaN
name: ENTPD5
type: Species
is: O75356

metaR OMHPALTD
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaR r0246
fast: false
kinetic law: MODEL1310110032#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110032#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110032#
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR PEPCKm
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
reversible: false
reactant: MODEL1310110032#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
kinetic law: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_3edac7e1_4b68_4cc1_b70f_f867f88fc505
is: E9PCP2
constant: false
name: CPT1B
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_6b8a2a7a_6378_4d50_b525_35c4bf8ee172
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: PRDX2
boundary condition: true
is encoded by: hsa:7001
type: Species

metaR DNDPt22m
is described by: ECO:0000269
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dUDP antiport
reactant: MODEL1310110032#
type: Reaction
modifier: MODEL1310110032#
is: SBO:0000185

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR AHCYStr
name: S-Adenosyl-L-homocysteine intracellular diffusion
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reversible: true

metaM nrpphrsf e
type: Species
is: http://identifiers.org/pubchem.compound/123747
constant: false
initial concentration: 1.0
is: HMDB02062
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

metaM HC02205 c
initial amount: NaN
is: CHEBI:28099
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
boundary condition: false
name: prostaglandin-b2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110032#_f18ff279_8e0d_4908_af8d_950a77f4d02f
name: ALDH4A1
is: SBO:0000252
boundary condition: true
is: P30038
type: Species
initial amount: NaN
is encoded by: hsa:8659
initial concentration: NaN
constant: false
has only substance units: false

metaR r0249
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
modifier: MODEL1310110032#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
kinetic law: MODEL1310110032#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR r0355
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaM thcrm hs g
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: trihexosyl ceramide
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
boundary condition: false
initial amount: NaN
is: CHEBI:24636
is: SBO:0000247

metaR FACOAL224
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110032#_5b39fdaf_9265_4b0a_9824_5b2fd45e4a58
type: Species
name: RDH16
is encoded by: hsa:8608
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: O75452
initial concentration: NaN

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: SBO:0000247
constant: false
name: calcium(2+)
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:29108
is: HMDB00464
initial concentration: 1.0
initial amount: NaN

metaR INSTt2r
modifier: MODEL1310110032#
is: SBO:0000185
name: inositol transport in via proton symport
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
reversible: true
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_ffdd28d3_45d4_448d_bfb4_812f6b2e7a52
initial amount: NaN
is encoded by: hsa:10380
constant: false
boundary condition: true
type: Species
has only substance units: false
is: O95861
is: SBO:0000252
name: BPNT1
initial concentration: NaN

metaR GAO1g
is described by: ECO:0000269
reversible: false
product: MODEL1310110032#
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
type: Reaction
is: SBO:0000176
name: Ganglioside O-acetylation

metaR TMDK1
reversible: false
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: thymidine kinase (ATP:thymidine)
is described by: ECO:0000269
reactant: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_63f81985_9390_4ab3_b0d4_67bddd0e3986
is encoded by: hsa:124
is: P07327
initial amount: NaN
name: ADH1A
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaR RE2677E
product: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: RE2677
is: SBO:0000176

metaM ppi x
type: Species
has only substance units: false
boundary condition: false
is: HMDB00250
name: Diphosphate
initial concentration: 1.0
is: CHEBI:33019
is: SBO:0000247
initial amount: NaN
is: C00013
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM e4hglu m
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: HMDB02273
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:6331
initial concentration: 1.0
initial amount: NaN
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110032#_055fdae8_ee38_4970_84b7_06c5282eeae6
constant: false
type: Species
name: SLC29A1
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q99808
is encoded by: hsa:2030

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
kinetic law: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
reactant: MODEL1310110032#
modifier: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110032#
name: riboflavin kinase

metaR UMPK5n
reactant: MODEL1310110032#
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110032#
fast: false
is: SBO:0000176
modifier: MODEL1310110032#
reversible: true

metaM gd3 hs g
initial amount: NaN
is: SBO:0000247
is: CHEBI:28424
type: Species
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR PIPLC
reversible: false
kinetic law: MODEL1310110032#
name: phosphatidylinositol phospholipase C
is: SBO:0000176
type: Reaction
reactant: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110032#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11

http://identifiers.org/biomodels.db/MODEL1310110032#_62401dde_e132_490b_a0b3_6a00b4911517
has only substance units: false
is: SBO:0000252
is: P21108
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:221823
type: Species
name: PRPS1L1
boundary condition: true

metaM dcamp c
is: CHEBI:57567
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00536
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
is: C03794
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR GTHRDt
kinetic law: MODEL1310110032#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110032#
reversible: true
name: Glutathione transport into mitochondria
type: Reaction
product: MODEL1310110032#

metaM glx m
is: SBO:0000247
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
is: CHEBI:36655
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaM CE5161 r
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false
initial amount: NaN
is: CHEBI:12947
is: SBO:0000247
has only substance units: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
type: Species
constant: false

metaM leu L m
is: HMDB00687
has only substance units: false
type: Species
name: L-leucine
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15603
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_fac59433_ccdc_42c1_8baf_0af073c3576d
type: Species
has only substance units: false
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000297

metaM s2l2n2m2masn e
name: de-Fuc form of PA6
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:3554
is: C00255
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00244
constant: false
notes: FORMULA: C84H135N6O61X CHARGE: -2

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM ak2lgchol hs e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6975
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: C04317
has only substance units: false

metaM glyclt x
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00115
is: CHEBI:29805
name: glycolate
initial amount: NaN
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110032#_90db1e6e_1b89_44e7_a0c3_9feff6730f45
is: SBO:0000252
name: SLC7A9
initial amount: NaN
is encoded by: hsa:11136
is: P82251
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR FAEL183
kinetic law: MODEL1310110032#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110032#
product: MODEL1310110032#
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reactant: MODEL1310110032#
reversible: false

metaR CHOLATEt
is: SBO:0000185
kinetic law: MODEL1310110032#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
type: Reaction
product: MODEL1310110032#
name: cholate transport via bicarbonate countertransport
is described by: ECO:0000269
reversible: true

metaM oxa m
initial concentration: 1.0
is: SBO:0000247
is: HMDB02329
is: CHEBI:30623
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

metaM ca2 c
constant: false
is: CHEBI:29108
type: Species
boundary condition: false
initial concentration: 1.0
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR RE2677G
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
kinetic law: MODEL1310110032#
reversible: false
name: RE2677

http://identifiers.org/biomodels.db/MODEL1310110032#_96f1350b_62b0_49cd_b730_053b24451d37
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: O75907
type: Species
is: SBO:0000252
constant: false
name: DGAT1
is encoded by: hsa:8694

metaR SUCOASm
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
product: MODEL1310110032#
is: SBO:0000176
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
fast: false
reactant: MODEL1310110032#
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM alpam m
initial amount: NaN
name: S-aminomethyldihydrolipoamide
constant: false
boundary condition: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06239

http://identifiers.org/biomodels.db/MODEL1310110032#_b07b9c2a_9629_40aa_8024_a822f4f67ef3
type: Species
is: SBO:0000252
name: AADAT
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51166
constant: false
is: Q4W5N8

metaM crn x
type: Species
has only substance units: false
is: CHEBI:16347
is: C00318
is: SBO:0000247
name: L-Carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
boundary condition: false
constant: false

metaR r0130
kinetic law: MODEL1310110032#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
modifier: MODEL1310110032#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110032#
type: Reaction
reversible: true

metaR RTOTAL3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
name: RTOTAL3 transport
is: SBO:0000185
kinetic law: MODEL1310110032#
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
reactant: MODEL1310110032#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_7622b826_2615_4ef3_a4b1_3ad3d0cda6b9
is: SBO:0000252
is encoded by: hsa:8310
initial amount: NaN
has only substance units: false
name: ACOX3
boundary condition: true
is: O15254
type: Species
constant: false
initial concentration: NaN

metaM cs b deg3 l
constant: false
type: Species
is: CHEBI:21338
initial concentration: 1.0
is: HMDB02704
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
boundary condition: false
is: SBO:0000247

metaR r0354
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110032#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110032#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaM oaa c
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
is: HMDB00223
is: CHEBI:3338
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00036
name: Oxaloacetate

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_f9e6f776_26ce_4ddb_9716_d85506d084bb
constant: false
is: O43280
name: TREH
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11181
initial concentration: NaN
initial amount: NaN

metaM HC01231 c
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaM ura e
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17568
is: HMDB00300
name: uracil
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

http://identifiers.org/biomodels.db/MODEL1310110032#_1dbe4241_0dc2_4cb6_83c7_3f873ab0a411
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: PPA1
is: Q15181
initial concentration: NaN
is encoded by: hsa:5464
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_60f7830c_3ec8_4ec7_861e_38a5db72a191
is: Q9NTF0
constant: false
is encoded by: hsa:875
is: SBO:0000252
boundary condition: true
name: CBS
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_ade00318_b4ab_44db_bde1_afcbf386f71d
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM cholate e
name: Cholate
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:29747

http://identifiers.org/biomodels.db/MODEL1310110032#_f1613514_5bdc_4bd0_9c5f_3cc31db3ee9a
is: SBO:0000252
name: NDUFC2
is encoded by: hsa:4718
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q549M5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_22dfae58_8bd0_4d02_9d25_ed8075eed440
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:2109
type: Species
is: SBO:0000252
boundary condition: true
name: ETFB
is: P38117

http://identifiers.org/biomodels.db/MODEL1310110032#_c7781d65_14d7_40b4_a65d_a1420b528c8c
type: Species
boundary condition: true
is: P00338
is encoded by: hsa:3939
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: LDHA
constant: false
has only substance units: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_589c25be_254d_480e_9504_45c965278e5d
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:10606
is: P22234
initial amount: NaN
name: PAICS

metaR UMPKn
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110032#
is described by: ECO:0000269
reactant: MODEL1310110032#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110032#
kinetic law: MODEL1310110032#
name: UMP kinase, nuclear
is: SBO:0000176

metaM dc2coa m
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:61406
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
type: Species
name: trans-Dec-2-enoyl-CoA

metaM dcyt n
type: Species
boundary condition: false
is: CHEBI:15698
constant: false
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
name: 2'-deoxycytidine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00014

http://identifiers.org/biomodels.db/MODEL1310110032#_975e13e6_4e12_40cd_9e45_fc383c45dea2
is encoded by: hsa:80150
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: ASRGL1
has only substance units: false
initial amount: NaN
is: Q7L266

http://identifiers.org/biomodels.db/MODEL1310110032#_56bcfbcf_31df_4eb5_8cc3_b677207281a8
is encoded by: hsa:J03866
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: _J03866_1_m

metaR r2360
kinetic law: MODEL1310110032#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110032#
product: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR THRGLNexR
reactant: MODEL1310110032#
name: L-threonine/glycine reversible exchange
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110032#
reversible: true
product: MODEL1310110032#

metaM dutp c
is: HMDB01191
is: SBO:0000247
name: dUTP
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: C00460
initial amount: NaN
has only substance units: false
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

metaR GULLACter
name: gulonolactone endoplasmic reticular transport
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is: SBO:0000185

metaR RDH3a
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reversible: true
reactant: MODEL1310110032#
type: Reaction
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (11-cis,NADPH)
fast: false
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

metaM fol e
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
initial concentration: 1.0
name: Folate
initial amount: NaN
has only substance units: false

metaM acac e
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:13705
is: SBO:0000247
type: Species
is: HMDB00060
constant: false
initial concentration: 1.0
name: acetoacetate

metaR BUTt2r
kinetic law: MODEL1310110032#
type: Reaction
fast: false
modifier: MODEL1310110032#
product: MODEL1310110032#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
reversible: true
reactant: MODEL1310110032#
name: Butyrate transport via proton symport, reversible

metaR ME2m
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
kinetic law: MODEL1310110032#
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
modifier: MODEL1310110032#
name: malic enzyme (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.40
product: MODEL1310110032#
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
is described by: ECO:0000000

metaM sphings c
is: CHEBI:57756
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
constant: false
name: sphingosine(1+)
is: HMDB00252
has only substance units: false
initial concentration: 1.0
type: Species

metaM nadh c
constant: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01487
is: CHEBI:57945
is: C00004
type: Species

metaM 5thf e
name: pentaglutamyl folate (THF)
initial amount: NaN
boundary condition: false
is: HMDB06487
constant: false
type: Species
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0464
reversible: true
type: Reaction
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110032#_2e269680_5514_4d4b_8a30_ef20dec21320
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:54
initial amount: NaN
is: SBO:0000252
name: ACP5
is: P13686
initial concentration: NaN
type: Species

metaM 3mb2coa m
boundary condition: false
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
has only substance units: false
type: Species
is: CHEBI:57344
is: SBO:0000247
initial concentration: 1.0

metaR D3AIBTm
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reversible: true
is: SBO:0000176
product: MODEL1310110032#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_bcedf9d7_ae8b_4516_86f9_b3620bcba339
has only substance units: false
is: P05062
is encoded by: hsa:229
initial concentration: NaN
boundary condition: true
name: ALDOB
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_ddf32b5f_a5d8_4da6_8a94_ad8d4bfff252
constant: false
name: ETFA
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2108
is: P13804
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR XYLTD Dr
fast: false
is: SBO:0000176
kinetic law: MODEL1310110032#
name: xylitol dehydrogenase (D-xyulose-forming)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
product: MODEL1310110032#
reactant: MODEL1310110032#
type: Reaction
reversible: true

metaR ACACT7p
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000269
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
kinetic law: MODEL1310110032#
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_57ad14fb_2d38_4702_a76c_62196f1fefea
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: HLCS
initial amount: NaN
is: P50747
is encoded by: hsa:3141
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110032#_cb21714c_de3b_488e_badf_be4a946631e8
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8876
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: VNN1
is: O95497
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_c79a9215_ef1f_4230_bbd9_084b0262a618
is encoded by: hsa:8867
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: SYNJ1
initial concentration: NaN
boundary condition: true
is: C9JFZ1
is: SBO:0000252

metaM CE5586 c
constant: false
is: CHEBI:58732
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
initial concentration: 1.0
type: Species
is: SBO:0000247
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium

metaR r2137
kinetic law: MODEL1310110032#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
reactant: MODEL1310110032#
modifier: MODEL1310110032#
product: MODEL1310110032#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110032#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
reversible: true
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
is: SBO:0000176
is described by: ECO:0000000

metaM ppi m
has only substance units: false
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
is: CHEBI:33019
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00250
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110032#_adfd086c_991d_4ba7_a2ee_61ea519c6bf5
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: PLCL1
boundary condition: true
constant: false
is encoded by: hsa:5334
is: Q15111

http://identifiers.org/biomodels.db/MODEL1310110032#_e457651c_c98c_4e1e_a281_ffdb46d1fc6c
type: Species
is: SBO:0000252
is: Q546Y9
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: AICDA
is encoded by: hsa:57379
initial concentration: NaN

metaM lnlncg l
type: Species
initial concentration: 1.0
is: CHEBI:32391
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
has only substance units: false
is: SBO:0000247
name: gamma-linolenate
initial amount: NaN
is: HMDB03073
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_734c5a76_bd9d_438e_ae58_95a001c73414
constant: false
is encoded by: hsa:248
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALPI
type: Species
is: P09923

metaM k c
name: potassium
constant: false
is: HMDB00586
is: SBO:0000247
is: C00238
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:29103
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species

http://identifiers.org/biomodels.db/MODEL1310110032#_0c40653c_8214_4a0b_a5a2_ef05d3352b38
constant: false
has only substance units: false
name: _AA788780_1_c
is encoded by: hsa:AA788780
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_dc11935d_cead_441c_b2f0_1c8eef98c21f
is: SBO:0000252
name: BTD
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: P43251
has only substance units: false
is encoded by: hsa:686
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_001b7f82_ab64_4c68_b3c1_b7ce47d0333d
type: Species
is encoded by: hsa:30061
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC40A1
is: Q9NP59
boundary condition: true

metaR PRO1x
is version of: http://identifiers.org/ec-code/1.5.99.8
reactant: MODEL1310110032#
is described by: ECO:0000134
modifier: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000176
reversible: false
name: L-ProlineNAD+ 5-oxidoreductase
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
kinetic law: MODEL1310110032#
fast: false
type: Reaction

metaR r0679
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110032#
is: SBO:0000176
reversible: true
modifier: MODEL1310110032#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is described by: ECO:0000000
product: MODEL1310110032#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaM lnlncgcoa c
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: CHEBI:57363
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
is: SBO:0000247

metaM acac c
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00060
initial concentration: 1.0
constant: false
has only substance units: false
name: acetoacetate
boundary condition: false
is: CHEBI:13705

http://identifiers.org/biomodels.db/MODEL1310110032#_818da1ba_0032_4a95_8fd9_5e663fab0a14
constant: false
initial concentration: NaN
initial amount: NaN
name: ECI2
type: Species
is: O75521
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10455
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110032#_581ffa1f_d245_4e36_808e_4ad0b73b5769
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6576
has only substance units: false
name: SLC25A1
constant: false
is: D9HTE9
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM arachdcoa r
name: arachidonoyl-CoA(4-)
is: HMDB06523
type: Species
is: CHEBI:57368
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0839
kinetic law: MODEL1310110032#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110032#
reactant: MODEL1310110032#
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000185
modifier: MODEL1310110032#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110032#_8c94223f_34a4_4087_b43c_1b9b1969e551
is: P16278
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:2720
constant: false
initial concentration: NaN
name: GLB1
boundary condition: true

metaM tym c
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
boundary condition: false
name: tyraminium
constant: false
initial amount: NaN
type: Species
is: CHEBI:327995
is: SBO:0000247
initial concentration: 1.0
is: HMDB00306

metaR URATEtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
fast: false
kinetic law: MODEL1310110032#
name: urate export from peroxisome
product: MODEL1310110032#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110032#

metaR r0463
fast: false
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110032#
type: Reaction
reversible: true
product: MODEL1310110032#
reactant: MODEL1310110032#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110032#_131c65b2_cc42_4c11_8801_e406cbed786d
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: HSD3B2
type: Species
is encoded by: hsa:3284
is: P26439
is: SBO:0000252
has only substance units: false

metaM hdcea r
boundary condition: false
constant: false
type: Species
is: CHEBI:32372
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
is: HMDB03229
name: palmitoleate
initial concentration: 1.0

metaM fol c
type: Species
is: HMDB00121
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
constant: false
name: Folate
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM glx x
is: HMDB00119
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: glyoxylate
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

http://identifiers.org/biomodels.db/MODEL1310110032#_e34064ec_e208_44bf_bfd7_3a7211c74072
name: GALNT5
boundary condition: true
has only substance units: false
type: Species
constant: false
is: A5PKZ1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11227

metaR DNDPt16m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via dADP antiport
reactant: MODEL1310110032#
product: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110032#
reversible: false

metaR r0838
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110032#
is: SBO:0000185
kinetic law: MODEL1310110032#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Free diffusion
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110032#

http://identifiers.org/biomodels.db/MODEL1310110032#_cc673b60_c787_442a_a7ef_e34f491c4e4f
boundary condition: true
initial amount: NaN
is: Q86SF2
is: SBO:0000252
initial concentration: NaN
constant: false
name: GALNT7
has only substance units: false
is encoded by: hsa:51809
type: Species

metaM cs a deg3 l
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: SBO:0000247
is: CHEBI:15748
type: Species
is: HMDB00127
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial concentration: 1.0

metaM HC01403 m
is: CHEBI:28325
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110032#_4713acb6_e19c_4dc0_bb76_305fc1a61996
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: B4DYG5
boundary condition: true
name: PI4KA
initial amount: NaN
is encoded by: hsa:5297

http://identifiers.org/biomodels.db/MODEL1310110032#_e8916592_06fe_4546_ad0c_49ee16e53a34
name: SLC6A5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9Y345
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:9152

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
product: MODEL1310110032#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/169691
type: Species
boundary condition: false
name: hexaglutamyl folate (THF)
constant: false
initial amount: NaN
initial concentration: 1.0

metaM etfox m
constant: false
name: Electron transfer flavoprotein oxidized
notes: FORMULA: R CHARGE: 0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01356
is: CHEBI:57312
boundary condition: false
initial concentration: 1.0

metaM dgdp c
is: C00361
is: SBO:0000247
is: HMDB00960
boundary condition: false
name: dGDP
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
is: CHEBI:58595
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110032#_3ca69751_7ba1_4dfb_b3b9_e13db99e0aa2
type: Species
initial amount: NaN
has only substance units: false
name: GART
constant: false
is encoded by: hsa:2618
is: SBO:0000252
initial concentration: NaN
is: P22102
boundary condition: true

metaR r1630
is: SBO:0000185
product: MODEL1310110032#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#

metaR GALASE12ly
reactant: MODEL1310110032#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110032#
modifier: MODEL1310110032#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR EX adp
kinetic law: MODEL1310110032#
reactant: MODEL1310110032#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaR BILGLCURtr
product: MODEL1310110032#
reactant: MODEL1310110032#
kinetic law: MODEL1310110032#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ

metaM leu L e
boundary condition: false
is: CHEBI:15603
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
is: HMDB00687
initial concentration: 1.0
initial amount: NaN

metaR F1PGT
is version of: http://identifiers.org/ec-code/2.7.7.30
modifier: MODEL1310110032#
fast: false
product: MODEL1310110032#
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110032#
is: SBO:0000176
reactant: MODEL1310110032#
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110032#_5b0dc558_a18f_4674_805b_5ddf47520d50
is encoded by: hsa:1040
has only substance units: false
constant: false
is: Q92903
name: CDS1
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR 3SALATAim
is described by: ECO:0000304
modifier: MODEL1310110032#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110032#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
reactant: MODEL1310110032#
product: MODEL1310110032#
reversible: false
type: Reaction
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial