metaM o2 x
is: HMDB01377
has only substance units: false
is: SBO:0000247
is: C00007
initial concentration: 1.0
boundary condition: false
name: O2
initial amount: NaN
type: Species
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false

metaR ITCOALm
is: SBO:0000176
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.5
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

metaR r2110
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_8da78dbd_b103_4df0_8b60_3b98bc559a76
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:F23536
name: _F23536_1_m
initial amount: NaN
is: SBO:0000252

metaM 35cgmp n
initial amount: NaN
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
has only substance units: false
boundary condition: false
name: 3',5'-cyclic GMP(1-)
is: CHEBI:57746
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaR RPEc
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: true
name: ribulose 5-phosphate 3-epimerase
fast: false

metaR r1624
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185

metaR GNDer
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
fast: false
type: Reaction
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reversible: false
reactant: MODEL1310110031#
is: SBO:0000176

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM chol c
is: SBO:0000247
is: C00114
is: HMDB00097
name: Choline
is: CHEBI:15354
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
type: Species
initial amount: NaN

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction

metaR TTDCRNt
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_7018dfd7_6f7e_4ce7_aaed_753565926332
is: Q9UI32
name: GLS2
boundary condition: true
is encoded by: hsa:27165
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM dhcholestanate x
is: HMDB00359
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
boundary condition: false

metaR VALt5m
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110031#
name: Valine reversible mitochondrial transport
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000

metaR r1593
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000

metaR DDCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM CE4794 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: cis-6-dodecenoyl-CoA
type: Species
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110031#_cd978681_e612_43d2_9dfb_e1d4cbab0697
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: Q9HBH5
has only substance units: false
constant: false
name: RDH14
is encoded by: hsa:57665
is: SBO:0000252

metaR 3SPYRSPm
type: Reaction
kinetic law: MODEL1310110031#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000

metaR FUMTSULtm
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185

metaR r1625
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR URIt5le
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110031#
name: uridine transport in via sodium symport (1:2)
product: MODEL1310110031#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185

metaM HC02213 c
constant: false
boundary condition: false
is: CHEBI:28031
type: Species
initial concentration: 1.0
name: prostaglandin-e3
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

http://identifiers.org/biomodels.db/MODEL1310110031#_9f046d98_d698_4289_8dd8_1051093b81d6
has only substance units: false
is encoded by: hsa:2875
is: SBO:0000252
constant: false
initial amount: NaN
name: GPT
boundary condition: true
type: Species
initial concentration: NaN
is: P24298

metaR HXPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.8
reversible: false
product: MODEL1310110031#
type: Reaction

metaM lnlncgcoa c
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB06368
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363

metaM ksii core4 g
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01644
name: keratan sulfate II (core 4-linked)
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: CHEBI:17140
constant: false
is: SBO:0000247

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR FAOXC102C101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaM gua c
initial concentration: 1.0
is: C00242
boundary condition: false
constant: false
name: Guanine
is: SBO:0000247
is: CHEBI:16235
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
type: Species
has only substance units: false

metaR r1594
fast: false
reactant: MODEL1310110031#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185

metaR ADCim
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
has only substance units: false
is: SBO:0000247
boundary condition: false
name: nLc8Cer
initial amount: NaN
type: Species
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false

metaR AG13T14g
modifier: MODEL1310110031#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_67f394fe_5db2_4ac2_b7bd_4c531fd1a809
initial concentration: NaN
name: NDUFB5
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4711
boundary condition: true
initial amount: NaN
is: O43674
constant: false

metaM ivcrn c
initial concentration: 1.0
notes: FORMULA: C12H23NO4 CHARGE: 0
is: SBO:0000247
name: isovaleryl carnitine
is: HMDB00688
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR r1622
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b0b273ce_3c19_4f58_aa96_e029527a800d
name: B4GALT5
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:9334
is: SBO:0000252
type: Species
is: O43286

metaR r2112
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#

metaR MGCHrm
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reversible: true
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_828d4b5c_851c_4f9a_96d6_b89623caffad
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8503
has only substance units: false
is: SBO:0000297
constant: false
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
has part: A7E2E0
type: Species
initial amount: NaN
has part: Q92569

metaM ksii core2 pre6 g
initial amount: NaN
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067
notes: FORMULA: C61H98N5O46SX CHARGE: -2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_156c2ec3_ae5b_4d7b_99c5_85b7e30cce00
initial concentration: NaN
initial amount: NaN
constant: false
is: O75438
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4707
type: Species
name: NDUFB1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_7beb093d_203e_4f25_a151_581ad96d404c
is: B4DKS0
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC16A1
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6566

metaM 4nph e
constant: false
is: SBO:0000247
name: 4-nitrophenolate
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
has only substance units: false
boundary condition: false
is: CHEBI:57917

metaR r1595
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e086585d_2926_49d1_b5e1_1c50b87f8008
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PDE5A
type: Species
is encoded by: hsa:8654
initial amount: NaN
is: G5E9C5

metaR GULLACter
name: gulonolactone endoplasmic reticular transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
fast: false
reversible: false

metaR r1623
is: SBO:0000185
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR r1596
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110031#_b62c1c4f_4c4c_4c26_8f69_de5ee75f6a5b
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9152
name: SLC6A5
is: Q9Y345
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM HC02213 e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: prostaglandin-e3
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
is: CHEBI:28031

http://identifiers.org/biomodels.db/MODEL1310110031#_3cd8166a_2dc1_49e8_aee5_acfd8dbc9f52
has only substance units: false
initial concentration: NaN
name: ALDOA
constant: false
type: Species
is encoded by: hsa:226
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r2111
product: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110031#

metaR NACHEXA21ly
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_dacf3ac7_7657_4606_bd6c_24f7e4fb63f2
is encoded by: hsa:6487
has only substance units: false
initial concentration: NaN
name: ST3GAL3
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_10e84749_e2ad_4122_93de_e17965d80f1d
is: P51857
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6718
name: AKR1D1
initial concentration: NaN
constant: false

metaM HC02202 e
boundary condition: false
has only substance units: false
is: CHEBI:57398
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR DHFR
is: SBO:0000176
name: dihydrofolate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reversible: true
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254

metaM hs deg1 l
is: HMDB06210
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110031#_b14765ba_07e0_40b1_a971_d733132f3669
constant: false
name: PDE8A
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110031#_e0b77d94_fa39_441f_b1c7_4f0204eeb923
is encoded by: hsa:54
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACP5
constant: false
is: P13686
initial amount: NaN
has only substance units: false

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000

metaM mi13p c
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
boundary condition: false
is: SBO:0000247
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
is: HMDB06234
constant: false
is: CHEBI:18225
initial amount: NaN

metaM c81crn e
constant: false
initial amount: NaN
has only substance units: false
is: HMDB13324
name: octenoyl carnitine
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM spmd e
initial amount: NaN
constant: false
name: Spermidine
is: HMDB01257
type: Species
is: C00315
boundary condition: false
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR DOLPMT3 Ler
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
is: SBO:0000176

metaM ivcrn e
is: HMDB00688
notes: FORMULA: C12H23NO4 CHARGE: 0
name: isovaleryl carnitine
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR FCOAH
type: Reaction
is: SBO:0000176
reversible: false
name: formyl coa hydrolase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM ksi pre34 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
is: C00130
boundary condition: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: HMDB00175
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58053
constant: false

metaM ksii core4 l
constant: false
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
is: CHEBI:17140
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01644

http://identifiers.org/biomodels.db/MODEL1310110031#_dd267723_fadb_479a_abf3_8201a2f2fa0d
constant: false
initial amount: NaN
has only substance units: false
is: P56181
is: SBO:0000252
type: Species
name: NDUFV3
initial concentration: NaN
is encoded by: hsa:4731
boundary condition: true

metaR r1629
product: MODEL1310110031#
type: Reaction
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0686
kinetic law: MODEL1310110031#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
reactant: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_52441ac8_a04b_41c8_9d55_9e36f5b98d3b
is: SBO:0000252
type: Species
boundary condition: true
name: GLUD2
initial concentration: NaN
is: P49448
is encoded by: hsa:2747
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_855fe57a_2b80_4383_8338_81e4d3a2da63
is encoded by: hsa:8704
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: B4GALT2
initial amount: NaN

metaR PI34P5K
is: SBO:0000176
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.68
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110031#
type: Reaction

metaR r1598
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000

metaM ksi deg4 l
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00868
type: Species
is: CHEBI:57737
name: keratan sulfate I, degradation product 4
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
constant: false
boundary condition: false
initial amount: NaN

metaR H5MTer U
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
name: H5 mannosyltransferase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR FAOXC163C142x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaR FAOXC16BRx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_89a30188_cd8e_4310_aba9_a699dc3cb6ce
constant: false
is: P78356
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8396
name: PIP4K2B
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaM nadp m
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58349
is: SBO:0000247
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
initial amount: NaN
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_5bc39c57_3243_4098_b923_98fec8de9ca6
is: SBO:0000252
is: O95497
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: VNN1
type: Species
is encoded by: hsa:8876

metaM dcdp n
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: CHEBI:58593
name: dCDP(3-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01245
initial amount: NaN

metaR r1626
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110031#

metaR H2O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110031#
name: hydrogen peroxide transport via diffusion
type: Reaction
fast: false

metaR r1599
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#

metaM ksi pre36 g
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 36
initial concentration: 1.0
notes: FORMULA: C247H394N17O210S11X CHARGE: -12

metaM c81crn c
has only substance units: false
name: octenoyl carnitine
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM lnlncacrn c
is: HMDB06319
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: alpha-linolenyl carnitine

metaM g3p c
boundary condition: false
is: CHEBI:58027
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: HMDB01112
initial amount: NaN
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
type: Species
has only substance units: false
initial concentration: 1.0
is: C00661
is: SBO:0000247

metaR DHORTS
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: dihydroorotase

metaM dcdp m
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
has only substance units: false
name: dCDP(3-)
constant: false
is: SBO:0000247
is: HMDB01245
initial amount: NaN
is: CHEBI:58593
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_9c68c42f_048e_4eea_b15d_76f7484444af
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:10317
is: SBO:0000252
name: B3GALT5
boundary condition: true
has only substance units: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1627
fast: false
product: MODEL1310110031#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185

metaR TSTSTERONEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
name: Testosterone transport
reversible: true
kinetic law: MODEL1310110031#

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
type: Reaction

metaM subeac x
notes: FORMULA: C8H12O4 CHARGE: -2
constant: false
name: suberic acid
initial concentration: 1.0
is: HMDB00893
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaM sphs1p r
initial amount: NaN
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00277

metaR C3STKR2r
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
name: C-3 sterol keto reductase (zymosterol)
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is described by: ECO:0000134
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176

metaR FAOXTC122TC101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM hexdectecoa m
boundary condition: false
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
type: Species
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110031#_64ef4837_d408_4273_9b79_23d5882d8431
constant: false
initial concentration: NaN
is: Q9Y5B8
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:29922
is: SBO:0000252
name: NME7
has only substance units: false

metaM 4fumacac c
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 4-fumarylacetoacetate(2-)
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
is: CHEBI:18034
is: HMDB01268

http://identifiers.org/biomodels.db/MODEL1310110031#_611df701_0d16_4dcc_9ce5_7409c4ba0e73
initial concentration: NaN
name: ATP1A1
is encoded by: hsa:476
type: Species
initial amount: NaN
constant: false
is: B7Z3U6
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_4469c5f2_5fc8_4b3f_bd81_e3ea9ae7c74b
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: O60909
name: B4GALT2
is encoded by: hsa:8704
initial concentration: NaN

metaM icit x
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00193
name: isocitrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_7eb441e0_ca00_4603_ab7d_3bce769c8da5
initial concentration: NaN
is encoded by: hsa:79695
constant: false
name: GALNT12
initial amount: NaN
is: Q8IXK2
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM hexdectecoa x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: 2,4,7,10-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110031#_9d0f627a_eba1_42a9_adaf_adaeb9c181c8
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:53354
constant: false
initial concentration: NaN
name: PANK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_6216982b_abb6_402b_ace6_6816c2a917f7
name: OGDHL
has only substance units: false
constant: false
is encoded by: hsa:55753
initial concentration: NaN
boundary condition: true
is: Q9ULD0
is: SBO:0000252
initial amount: NaN
type: Species

metaR KYNATESYN
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
reactant: MODEL1310110031#
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000

metaR Q10H2e
kinetic law: MODEL1310110031#
is: SBO:0000185
reversible: true
reactant: MODEL1310110031#
name: transport of ubiquinol into lymph
type: Reaction
product: MODEL1310110031#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

metaM 4hbzcoa m
is: HMDB06467
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 4-hydroxybenoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_51316145_987c_4920_841c_3963a62011a8
name: B3GALT5
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:10317
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110031#
type: Reaction
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000176

metaR DURAD2
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)

metaR SO4HCOtex
is described by: ECO:0000304
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
modifier: MODEL1310110031#
name: sulfate transport via bicarbonate countertransport
reversible: false
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction

metaR DOLPMT1 Uer
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.258
product: MODEL1310110031#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
kinetic law: MODEL1310110031#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_8b0d891b_60df_455f_ab5b_316def0efcd0
has only substance units: false
type: Species
constant: false
name: NOS1
is: SBO:0000252
is: B4DG68
initial concentration: NaN
is encoded by: hsa:4842
initial amount: NaN
boundary condition: true

metaM uri e
constant: false
has only substance units: false
type: Species
is: C00299
is: SBO:0000247
initial amount: NaN
name: Uridine
boundary condition: false
initial concentration: 1.0
is: HMDB00296
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

metaR SBTR
name: D-sorbitol reductase
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
product: MODEL1310110031#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110031#

metaM c51crn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02366
type: Species
notes: FORMULA: C12H21NO4 CHARGE: 0
is: SBO:0000247
name: tiglyl carnitine
constant: false

metaR EX ivcrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaR S6TASE25ly
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
fast: false
reversible: true

metaR NDP7ex
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UDP), extracellular
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110031#

metaR HSAT2ly
reversible: false
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110031#

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
constant: false
is: C00130
type: Species
initial concentration: 1.0
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
boundary condition: false
initial amount: NaN

metaR 5HOXINDACTO2OX
fast: false
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110031#
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez

http://identifiers.org/biomodels.db/MODEL1310110031#_9b43328d_633a_48a9_830c_b5be8dc3a937
name: HSD17B4
is encoded by: hsa:3295
type: Species
is: E9PB82
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
name: intracellular transport
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false

metaM sphs1p e
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: SBO:0000247
is: HMDB00277
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
constant: false
is: CHEBI:60119
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_48b4867f_4b59_449d_9a59_1457d51dc6ae
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GGT2
is encoded by: hsa:728441
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM spmd c
type: Species
is: SBO:0000247
is: CHEBI:57834
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: HMDB01257
initial amount: NaN
name: Spermidine
initial concentration: 1.0
constant: false
is: C00315

http://identifiers.org/biomodels.db/MODEL1310110031#_90a31235_ae9f_40aa_a9cc_50dbf323b5c9
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: ST3GAL2
is: SBO:0000252
constant: false
is: Q16842
initial amount: NaN
is encoded by: hsa:6483

http://identifiers.org/biomodels.db/MODEL1310110031#_63b692fa_0e75_4d7c_8aa8_b452c1f54cde
initial amount: NaN
name: UAP1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q16222
is encoded by: hsa:6675
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_1c31f50b_60b5_4d87_8030_e610ff58a5b4
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI222095
name: _AI222095_1_m

metaR HESTRATRIOLtr
name: hydroxylated estrogen derivative transport
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_a09e4b5d_7dba_4707_86c7_6d23cc237c59
is encoded by: hsa:284129
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC26A11
initial amount: NaN
is: Q86WA9
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_24d5a1b5_63ea_4be8_b261_43a308260d52
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
type: Species
is: SBO:0000252
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110031#_d8aa4a9a_f961_40d3_8e5f_85b9f37ddfe5
is: Q9UKG4
is: SBO:0000252
initial concentration: NaN
name: SLC13A4
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:26266

metaM c51crn e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: tiglyl carnitine
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
boundary condition: false
type: Species
initial amount: NaN

metaM uri c
is: HMDB00296
constant: false
type: Species
is: C00299
name: Uridine
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
has only substance units: false

metaR FOLt2le
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
product: MODEL1310110031#

metaR C181OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_49bb0cff_fad1_48ca_b092_080a566b89eb
is: Q8WUX1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:92745
constant: false
name: SLC38A5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_536eb47a_45ae_48f1_84d0_8693e5ea0599
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: O60503
is: SBO:0000252
boundary condition: true
name: ADCY9
is encoded by: hsa:115
constant: false

metaR r0797
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
name: glycine N-choloyltransferase EC:2.3.1.65
modifier: MODEL1310110031#
type: Reaction

metaR LNELDCCRNt
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110031#
is: SBO:0000185
reversible: false
fast: false
is described by: ECO:0000000

metaR RE1897C
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
fast: false
reversible: true
name: RE1897
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110031#

metaM 3mob m
is: HMDB00019
initial amount: NaN
is: CHEBI:11851
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247

metaM nadp c
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00217
is: CHEBI:58349
initial concentration: 1.0
type: Species
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

metaR r0792
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
reversible: true
kinetic law: MODEL1310110031#

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_7d379195_2213_4694_9978_fb1be3054ba8
constant: false
has only substance units: false
is: SBO:0000252
name: _AI934540_1_c
type: Species
boundary condition: true
is encoded by: hsa:AI934540
initial concentration: NaN
initial amount: NaN

metaM octa c
initial concentration: 1.0
is: C06423
name: octanoate (n-C8:0)
notes: FORMULA: C8H15O2 CHARGE: -1
type: Species
is: HMDB00482
is: CHEBI:25646
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

metaM acetol c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: HMDB06961
type: Species
has only substance units: false
initial concentration: 1.0
name: hydroxyacetone
initial amount: NaN
boundary condition: false
is: CHEBI:27957
constant: false
is: SBO:0000247

metaM mmcoa R m
has only substance units: false
is: CHEBI:57326
type: Species
name: (R)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01269
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_1777d37b_211f_421e_95ed_8cbb4b641014
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ABAT
initial concentration: NaN
is encoded by: hsa:18

metaM arachcoa c
type: Species
initial amount: NaN
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB04258
initial concentration: 1.0
is: CHEBI:15527

http://identifiers.org/biomodels.db/MODEL1310110031#_85de643a_6833_4919_b5c8_5568918c8325
name: ACAA1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q96CA6
is encoded by: hsa:30
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0791
fast: false
reversible: true
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR DNDPt8m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
product: MODEL1310110031#
name: dADP transport via dUDP antiport
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_e7ce5877_4636_4d4a_9ef0_e50c6b6b3728
is: P43007
is encoded by: hsa:6509
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: SLC1A4

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
has only substance units: false
is: CHEBI:57398
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: prostaglandin A1(1-)

metaM tdcoa c
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
is: C02593
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
constant: false
is: CHEBI:57385
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0f66aff6_cf9e_44c9_9f8c_e2bdd22eae78
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: O15270
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9517
name: SPTLC2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_8e149e74_f67a_43e7_bca3_028b9f0c3d43
is: SBO:0000252
type: Species
name: CA13
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q8N1Q1
is encoded by: hsa:377677
constant: false
initial amount: NaN

metaR NADPtru
type: Reaction
is: SBO:0000185
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaM ncam e
name: Nicotinamide
is: CHEBI:0
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C6H6N2O CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01406
constant: false
is: C00153

metaM tetdecdicoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 5,8-tetradecadienoylcoa
type: Species
initial amount: NaN
is: SBO:0000247

metaM nadp e
is: HMDB00217
has only substance units: false
is: CHEBI:58349
type: Species
name: NADP+(3-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
initial amount: NaN

metaM 5eipencoa m
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
name: 5,8,11,14,17-eicosapentenoylcoa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_d58c6371_89dd_424c_967f_d2a7cdf1e435
initial concentration: NaN
name: RDH16
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: O75452
initial amount: NaN
is encoded by: hsa:8608
constant: false

metaM octa e
is: CHEBI:25646
initial concentration: 1.0
constant: false
is: HMDB00482
name: octanoate (n-C8:0)
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
is: C06423
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR HMGCOASi
kinetic law: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
type: Reaction
product: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.3.10

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_aa78770d_357d_4a9d_b961_c95ad8e48a2a
constant: false
initial concentration: NaN
name: ALPP
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:250
boundary condition: true
is: P05187
is: SBO:0000252

metaM hdd2coa c
is: HMDB03945
initial concentration: 1.0
is: C05272
type: Species
is: SBO:0000247
constant: false
is: CHEBI:61526
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false

metaR RE2649C
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: RE2649
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
modifier: MODEL1310110031#

metaR GALASE6ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reversible: false
product: MODEL1310110031#
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110031#_7f89593f_6fde_49a3_9c02_e80dc6db70d3
constant: false
is: P42336
is: SBO:0000252
is encoded by: hsa:5290
type: Species
boundary condition: true
name: PIK3CA
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_adc86f5e_5c08_44a3_b19a_77fe557686bc
name: _AA614647_1_c
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:AA614647
initial concentration: NaN
type: Species

metaM ru5p D c
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial amount: NaN
boundary condition: false
has only substance units: false
name: D-ribulose 5-phosphate(2-)
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00618

metaM 3hmbcoa m
is: CHEBI:57312
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
type: Species
is: HMDB01356
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_ceb3ad5e_18bb_4cb5_9ec4_999c65518094
is: P04181
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4942
name: OAT
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR NDP7er
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
reversible: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is: SBO:0000176
type: Reaction

metaR r0680
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e46ed56f_7b8e_4443_af41_f99cf71e695a
is encoded by: hsa:23475
is: Q15274
name: QPRT
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaM glyc R c
is: CHEBI:16659
name: D-glycerate
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00139
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a945cc7a_0fb2_4601_9b16_036cb495148b
is: Q9NPC4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53947
constant: false
name: A4GALT

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM datp c
is: C00131
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
initial amount: NaN
is: SBO:0000247
is: HMDB01532
boundary condition: false
initial concentration: 1.0
name: dATP
has only substance units: false
type: Species

metaM ksii core4 e
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
initial concentration: 1.0
type: Species
is: HMDB00211
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR r1487
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#
name: EC:6.2.1.3
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false

metaR FRDPtc
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110031#
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
fast: false

metaM lnlncacrn m
name: alpha-linolenyl carnitine
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
constant: false
is: HMDB06319
initial concentration: 1.0
type: Species

metaR P5CRxm
is described by: ECO:0000304
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
is: SBO:0000176
reactant: MODEL1310110031#
name: pyrroline-5-carboxylate reductase (m)
product: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false

metaM dgtp c
is: CHEBI:16497
is: HMDB01440
initial concentration: 1.0
initial amount: NaN
name: dGTP
constant: false
is: C00286
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
has only substance units: false

metaR OLEICFATPtc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM dudp c
is: SBO:0000247
type: Species
is: HMDB01000
initial concentration: 1.0
constant: false
is: CHEBI:60471
is: C01346
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP
boundary condition: false

metaR RE3244R
reactant: MODEL1310110031#
name: RE3244
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false

metaM ksi pre27 g
name: keratan sulfate I biosynthesis, precursor 27
constant: false
boundary condition: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
has only substance units: false
is: HMDB00175
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58053
is: C00130

metaR TETDEC2CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_a8a62fe1_e910_4c72_af92_24a364f91457
constant: false
boundary condition: true
is encoded by: hsa:197257
initial concentration: NaN
name: LDHD
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_aad24cf7_c140_4714_9717_e46cc8432a33
initial concentration: NaN
is encoded by: hsa:AV717590
boundary condition: true
name: _AV717590_1_m
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM phyt2ohcoa x
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial amount: NaN
name: 2-hydroxyphytanoyl-CoA(4-)
is: HMDB01295
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57334

metaR r2408
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_08e4df31_48de_460f_89bb_846ae93e3f29
type: Species
name: ADSL
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:158
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_fd3c12d0_ae77_46ac_ac5e_a3cd25a1ee2d
initial concentration: NaN
constant: false
boundary condition: true
name: ECI2
is: SBO:0000252
is encoded by: hsa:10455
initial amount: NaN
has only substance units: false
type: Species
is: O75521

metaR LEUKTRB4t
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
type: Reaction
name: leukotriene B4 transport
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_2ecbe969_a79d_465b_837d_0fe793bdb534
name: _T83654_1_m
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:T83654
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR DHCR71r
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
modifier: MODEL1310110031#
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110031#
type: Reaction

metaR M4MPDOL Uter
reversible: false
name: m4mpdol flippase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#

metaM ncam c
notes: FORMULA: C6H6N2O CHARGE: 0
is: HMDB01406
name: Nicotinamide
boundary condition: false
initial amount: NaN
is: C00153
is: SBO:0000247
is: CHEBI:0
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

metaM ksii core2 pre8 g
initial concentration: 1.0
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00175
has only substance units: false
constant: false
is: CHEBI:58053
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 8
is: C00130

metaM dcdp c
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
initial concentration: 1.0
is: C00705
has only substance units: false
name: dCDP
is: HMDB01245
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110031#_b59a9444_cb3c_4564_94b5_334694e44267
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5831
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: PYCR1
is: A6NFM2

metaR PPAm
kinetic law: MODEL1310110031#
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_e4dad69a_e54a_4131_b06b_e361b3869920
is encoded by: hsa:230
is: P09972
constant: false
type: Species
name: ALDOC
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR B3GALT3g
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.79
is: SBO:0000176
fast: false
name: Beta-1,3-galactosyltransferase 3
reversible: false

metaR r0365
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
modifier: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110031#_db8b6a6c_27fd_443b_aa39_4da3db460c09
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:R33828
name: _R33828_1_c

metaR NACHEX25ly
kinetic law: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR S6T3g
reversible: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.21
is described by: ECO:0000000
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110031#
is: SBO:0000176

metaR PDE1
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
type: Reaction
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.35
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is described by: ECO:0000269

metaR PIt8
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000006
modifier: MODEL1310110031#
reversible: true
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_2ceddba6_80d2_4812_8522_84b3e68eefe0
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: TKTL2
boundary condition: true
is encoded by: hsa:84076
is: Q9H0I9

http://identifiers.org/biomodels.db/MODEL1310110031#_738f0111_adaa_452e_a806_9cb255a5d71f
constant: false
is encoded by: hsa:79053
type: Species
name: ALG8
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM subeac c
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: suberic acid
type: Species
constant: false
is: HMDB00893
initial concentration: 1.0
notes: FORMULA: C8H12O4 CHARGE: -2

metaR HOCDACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM andrstrn r
initial amount: NaN
is: CHEBI:16032
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species
is: HMDB00031
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: androsterone
constant: false

metaM 5oxpro e
is: HMDB00267
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
boundary condition: false
has only substance units: false
is: CHEBI:57606
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_d57160ac_23c7_42f2_9a5b_fb85997cd38a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: STARD3
type: Species
boundary condition: true
initial amount: NaN
is: B4DUY1
constant: false
is encoded by: hsa:10948

http://identifiers.org/biomodels.db/MODEL1310110031#_75d1d13a_ab91_4633_8012_371ca85cd03c
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GLB1
is: SBO:0000252
is: P16278
is encoded by: hsa:2720
type: Species

metaM 34dhphe c
is: CHEBI:15765
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00181
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
name: L-dopa
constant: false

metaM zym int2 r
name: zymosterol intermediate 2
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
is: CHEBI:52386
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM 3dphb m
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06251
initial concentration: 1.0
name: 3-Decaprenyl-4-hydroxybenzoate

metaR DGSNt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoyguanosine transport via diffusion
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false

metaR FAOXC8C6m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR C181CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: C181 transport into the mitochondria
reactant: MODEL1310110031#
fast: false
reversible: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#

metaR PIt7
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
product: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
name: phosphate transport in/out via three Na+ symporter
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: true

metaM gly e
constant: false
type: Species
is: CHEBI:3339
has only substance units: false
is: C00037
is: HMDB00123
name: Glycine
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM o2 e
has only substance units: false
name: O2
is: HMDB01377
type: Species
initial concentration: 1.0
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR CHOLtu
reactant: MODEL1310110031#
name: Choline uniport
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000185

metaM pro L m
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
is: HMDB00162
is: CHEBI:17203

metaR M13N2Tg
is described by: ECO:0000000
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.101
fast: false
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR G14T14g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110031#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_6962761f_56f3_4ab8_b60b_6f50c5d3f1c9
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3037
name: HAS2
is: Q92819
boundary condition: true

metaM dolmanp U c
boundary condition: false
has only substance units: false
type: Species
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM 3mob c
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
is: CHEBI:11851
is: HMDB00019
initial amount: NaN
name: 3-methyl-2-oxobutanoate
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR r0787
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
modifier: MODEL1310110031#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176

metaM pro L e
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
initial concentration: 1.0
constant: false
is: CHEBI:17203
boundary condition: false
is: HMDB00162

metaM sebcoa c
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: sebacoylcoa
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00651

metaR FAOXC15C13m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR DOLPH Uer
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110031#
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110031#
reversible: false
product: MODEL1310110031#

metaM HC01603 c
has only substance units: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
name: 10-Formyltetrahydrofolate
is: C00234
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaM 5oxpro c
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
has only substance units: false
type: Species
is: HMDB00267
is: SBO:0000247
is: CHEBI:57606
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_34ceacfc_c62a_4585_9c72_50d5e2f35fc3
is: SBO:0000252
is encoded by: hsa:206358
boundary condition: true
name: SLC36A1
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: Q1LZ56

metaM sphs1p c
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR TYRt
type: Reaction
product: MODEL1310110031#
fast: false
name: L-tyrosine transport
is: SBO:0000185
modifier: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reversible: true

metaM phaccoa c
boundary condition: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
is: HMDB06503
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57390
type: Species
name: phenylacetyl-CoA(4-)
initial amount: NaN

metaR RE2799C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110031#
name: RE2799
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true

metaR CYSO
kinetic law: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110031#
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT

metaR 3MOBt2im
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
product: MODEL1310110031#
type: Reaction

metaR r0788
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
reversible: true
product: MODEL1310110031#

metaM gly c
name: Glycine
constant: false
has only substance units: false
is: CHEBI:3339
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR NRPPHRtu
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000185
fast: false
reversible: true
name: Norepinephrine uniport

metaM retinol cis 11 c
type: Species
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
is: SBO:0000247
is: HMDB06216
name: 11-cis-retinol
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR C5DCe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_cace223f_3e2c_41f8_90a9_797a460ec4aa
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10380
is: SBO:0000252
name: BPNT1
type: Species
boundary condition: true
is: O95861

metaM sql r
has only substance units: false
constant: false
is: CHEBI:15440
is: SBO:0000247
is: HMDB00256
initial concentration: 1.0
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial amount: NaN
boundary condition: false
type: Species

metaR r0360
type: Reaction
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR ASNtN1
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
reversible: true

metaR 41R2A1H12BOOX
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110031#
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
reactant: MODEL1310110031#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4

http://identifiers.org/biomodels.db/MODEL1310110031#_af2ec9a2_489a_419d_b98c_a801243f620b
has only substance units: false
is encoded by: hsa:6515
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC2A3
constant: false
boundary condition: true
is: P11169

metaR FADDPle
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110031#
name: FAD diphosphatase
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110031#
type: Reaction

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: Choline transport, nuclear through pores
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110031#

metaM hdd2coa m
initial concentration: 1.0
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
is: C05272
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: SBO:0000247
is: HMDB03945

http://identifiers.org/biomodels.db/MODEL1310110031#_ee0361b3_f3c6_4c32_b07f_3f5744a1fcfa
type: Species
is: A6NED0
is: SBO:0000252
name: GSTZ1
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2954

http://identifiers.org/biomodels.db/MODEL1310110031#_a65f0036_c1e6_455f_aaa6_b4f085cc4e70
has only substance units: false
initial concentration: NaN
is: Q8IZH9
initial amount: NaN
boundary condition: true
is encoded by: hsa:2643
is: SBO:0000252
type: Species
constant: false
name: GCH1

metaM dcyt n
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: CHEBI:15698
has only substance units: false
is: HMDB00014
name: 2'-deoxycytidine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_7a243746_891c_4dce_8b96_4cc7ed27d343
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: LDHB
is encoded by: hsa:3945
type: Species
constant: false
is: P07195

metaM 35cgmp c
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
constant: false
is: CHEBI:57746
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3',5'-cyclic GMP(1-)
initial concentration: 1.0

metaR NADPHtxu
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is described by: ECO:0000000
name: NADPH transporter, peroxisome
fast: false
reversible: false

metaR r0789
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110031#

MODEL1310110031#
species: metaM dhcrm hs c
species: metaM bilglcur r
species: metaM 3octdece1coa m
species: metaM fuc L c
species: metaM 3hexdtricoa x
species: metaM Sfglutth c
species: metaM HC00319 c
species: metaM mi13p c
species: metaM amp r
species: metaM glyb c
species: metaM HC01361 e
species: metaM succoa c
species: metaM dodecanac x
species: metaM gluside hs c
species: metaM retinal c
species: metaM 2octdectecoa x
species: metaM xoldiolone r
species: metaM c4dc c
species: metaM fuc1p L c
species: metaM octa c
species: metaM T antigen g
species: metaM hdca e
species: metaM dutp c
species: metaM gly c
stoichiometry: 0.005829
species: metaM crm hs l
species: metaM adpcoa x
species: metaM ksi pre8 g
species: metaM 3octdece1crn c
species: metaM CE5868 e
species: metaM dcsptn1coa c
species: metaM m4mpdol U c
species: metaM lneldccrn m
species: metaM ksii core2 deg1 l
species: metaM tre e
species: metaM udpacgal g
species: metaM udpgal g
species: metaM sucsal m
species: metaM 3hmbcoa m
species: metaM adprib c
species: metaM 1pyr5c c
species: metaM pail45p hs m
species: metaM CE2839 e
species: metaM pchol hs e
species: metaM acglcgalgluside hs g
species: metaM Asn X Ser Thr l
species: metaM dmpp x
species: metaM CE5119 m
species: metaM g3m8mpdol L r
species: metaM dcyt n
species: metaM lnlncacoa c
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
species: metaM 13 cis retn r
species: metaM dpcoa m
species: metaM pail34p hs c
species: metaM HC00591 c
species: metaM 3ttetddcoacrn c
species: metaM 3mop c
species: metaM c81crn c
species: metaM ascb L e
species: metaM 2decdicoa x
species: metaM 4abutn c
species: metaM galgalgalthcrm hs e
species: metaM 5htrp c
species: metaM ala D c
species: metaM datp c
species: metaM s2l2n2m2m l
species: metaM 13dpg c
species: metaM CE5160 r
species: metaM 4mop m
species: metaM xol7ah3 m
species: metaM ksi deg36 l
species: metaM 5mta e
species: metaM dhcholoylcoa x
species: metaM ala D e
species: metaM fadh2 c
species: metaM acnam l
species: metaM dgtp e
species: metaM 6pgc r

metaR HEXCOAACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM lys L m
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00182
name: L-lysinium(1+)
type: Species

metaM dgtp e
has only substance units: false
boundary condition: false
is: HMDB01440
initial amount: NaN
constant: false
type: Species
name: dGTP
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR LTC4CP
kinetic law: MODEL1310110031#
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction

metaM 3mob e
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: 3-methyl-2-oxobutanoate
is: HMDB00019
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110031#_a85c1062_bcae_4a08_9a28_12914dda5574
boundary condition: true
name: ALDH3B2
type: Species
is encoded by: hsa:222
is: SBO:0000252
is: P48448
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaM chol n
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15354
name: choline
type: Species
is: HMDB00097
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_db8a1ec8_57a6_4366_8efc_1e4ab5df5fa1
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: E9PHN8
is encoded by: hsa:9843
boundary condition: true
name: HEPH
initial concentration: NaN
is: SBO:0000252

metaM acetone m
initial amount: NaN
is: HMDB01659
is: CHEBI:15347
constant: false
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial concentration: 1.0
name: acetone
is: SBO:0000247
boundary condition: false

metaR PPM
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
name: phosphopentomutase
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110031#

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB11123
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110031#_7687d589_76d3_4e0f_b368_46d4eda52201
initial concentration: NaN
name: NT5C1B
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:93034
is: B3KUK6
constant: false

metaM bildglcur r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58471
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
constant: false
is: HMDB03325
initial amount: NaN
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaM prostgh2 r
boundary condition: false
is: HMDB01381
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
initial concentration: 1.0
is: CHEBI:57405
constant: false
name: prostaglandin H2(1-)
type: Species

metaR PDE4
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.35
name: 3',5'-cyclic-nucleotide phosphodiesterase

http://identifiers.org/biomodels.db/MODEL1310110031#_86ed2e07_24fd_458b_807d_c08a8da0966a
constant: false
is: P28331
is encoded by: hsa:4719
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NDUFS1
type: Species
initial amount: NaN

metaR ESTRADIOLt
name: estradiol transport
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction

metaM icit m
type: Species
is: C00311
is: CHEBI:16087
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00193
name: Isocitrate

metaR RNDR3
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (CDP)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
is described by: ECO:0000269
reversible: false

metaM m4masn g
is: SBO:0000247
is: C05881
boundary condition: false
has only substance units: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaM n2m2nmasn l
type: Species
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaM chol m
boundary condition: false
is: CHEBI:15354
name: choline
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097

http://identifiers.org/biomodels.db/MODEL1310110031#_374595d0_e8c7_4033_a4e0_baf632569d56
has only substance units: false
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3
is: SBO:0000252
initial concentration: NaN
is: Q5T4Y1
type: Species
constant: false

metaR FUMSO3tm
name: Fumarate:sulfite antiport, mitochondrial
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_746c7e40_7b23_4486_a237_e5322e494d59
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P16152
name: CBR1
is encoded by: hsa:873
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM glyc R m
is: CHEBI:16659
name: D-glycerate
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00139
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

http://identifiers.org/biomodels.db/MODEL1310110031#_9561849f_1901_4622_a082_933da7a40097
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _D87002_1_m
initial amount: NaN
type: Species
is encoded by: hsa:D87002
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_97ebcadc_6ac6_4b2c_bba0_753ce37037f8
is: Q9UF12
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:58510
boundary condition: true
name: PRODH2

metaM n2m2nmasn g
boundary condition: false
is: C04946
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial concentration: 1.0

metaM fadh2 c
is: HMDB01197
boundary condition: false
has only substance units: false
name: FADH2(2-)
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR GALGLUSIDEtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110031#
name: galgluside hs intracellular transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false

metaM dolp U r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
name: dolichyl phosphate(2-)
is: CHEBI:57683
constant: false
initial amount: NaN
type: Species

metaR r2117
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110031#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_997399a8_5f5b_40f3_b3b4_537ce97d2f96
is: SBO:0000252
constant: false
is encoded by: hsa:3033
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: HADH
is: Q16836
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_a37165af_7892_489d_bada_5de31a5b2dd9
is: SBO:0000297
name: VNN3:VNN2:VNN1
initial concentration: NaN
is encoded by: hsa:55350
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_6ba08fdd_9aa4_413b_8f30_088397cdcc2e
is: SBO:0000252
constant: false
name: ABCD1
is: P33897
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:215
has only substance units: false

metaM dhor S c
initial concentration: 1.0
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: CHEBI:30864
boundary condition: false
initial amount: NaN
name: (S)-dihydroorotate
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB03349

http://identifiers.org/biomodels.db/MODEL1310110031#_996dca9a_5adb_45d8_850d_93dfd485749b
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: _728226_1_m
type: Species
is: SBO:0000252
is encoded by: hsa:728226

metaR FAOXC61x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR r2118
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR AG13T1g
type: Reaction
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaR SUBERCROT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR GUAPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
name: guanine phosphoribosyltransferase
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM tmndnc e
has only substance units: false
name: timnodonic acid C20:5, n-3
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB01999
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284

metaR r0679
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reversible: true
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176

metaR PGISr
modifier: MODEL1310110031#
name: Prostaglandin I2 synthase
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.3.99.4
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false

metaR GMPtn
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110031#
name: GMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is: SBO:0000185

metaM lnlncgcoa m
type: Species
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
boundary condition: false
is: CHEBI:57363
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
constant: false
is: SBO:0000247

metaM prostgh2 e
is: CHEBI:57405
has only substance units: false
is: SBO:0000247
name: prostaglandin H2(1-)
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
is: HMDB01381

metaR r2119
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM o2 n
initial concentration: 1.0
is: CHEBI:15379
type: Species
boundary condition: false
has only substance units: false
name: dioxygen
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial amount: NaN
constant: false

metaM dudp m
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01000
name: dUDP(3-)
is: CHEBI:60471

metaR GLU5Km
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.41
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000254
name: glutamate 5-kinase (m)

metaM nadp x
initial concentration: 1.0
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: CHEBI:58349
initial amount: NaN
is: HMDB00217
constant: false
is: C00006
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_add2c03f_3ab2_419a_bfda_e65d2aadb8a7
is: P13995
type: Species
is encoded by: hsa:10797
initial amount: NaN
constant: false
initial concentration: NaN
name: MTHFD2
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR CYTK1n
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110031#
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM pro L c
is: SBO:0000247
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
boundary condition: false
is: HMDB00162
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: L-proline

metaM o2 m
boundary condition: false
is: SBO:0000247
is: CHEBI:15379
constant: false
is: HMDB01377
initial concentration: 1.0
name: O2
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
has only substance units: false
type: Species

metaR PRASCS
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
type: Reaction
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_df4b698a_3a50_46fa_a49c_5eb244a3320e
has only substance units: false
has part: P14415
initial concentration: NaN
constant: false
type: Species
is: SBO:0000297
boundary condition: true
name: ATP1A3:ATP1B2
is encoded by: hsa:482
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_44b6b4bb_558e_4867_a0dc_e81942fd09dd
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:23428
name: SLC7A8
is: Q9UHI5

metaM dudp n
initial concentration: 1.0
name: dUDP(3-)
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01000
is: SBO:0000247
is: CHEBI:60471

metaR PPA
kinetic law: MODEL1310110031#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR CYTK1m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
reversible: true
name: cytidylate kinase (CMP),mitochondrial
type: Reaction

metaM 34dhphe e
boundary condition: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
is: SBO:0000247
constant: false
is: HMDB00181
initial amount: NaN
is: CHEBI:15765
type: Species
initial concentration: 1.0
name: L-dopa
has only substance units: false

metaR r1590
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2113
is: SBO:0000185
reversible: true
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM lys L c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00182
constant: false
initial amount: NaN
name: L-lysinium(1+)
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_76c88983_18d8_46ca_afe7_5000f7b59e87
initial amount: NaN
name: SLC13A2
is: SBO:0000252
constant: false
is encoded by: hsa:9058
boundary condition: true
initial concentration: NaN
is: E7ETH5
has only substance units: false
type: Species

metaR ALOX52
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
fast: false
type: Reaction

metaM adrnl c
initial amount: NaN
name: Adrenaline
is: SBO:0000247
constant: false
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788
is: CHEBI:33568
is: HMDB00068
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR r1633
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
type: Reaction

metaM nadp r
initial amount: NaN
is: HMDB00217
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: C00006

metaR MTHFD2m
fast: false
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
type: Reaction
reversible: true
product: MODEL1310110031#

metaR GALGLUSIDEtl
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110031#
name: galgluside hs intracellular transport
is: SBO:0000185
fast: false

metaR r2114
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
fast: false
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR ADKd
type: Reaction
is: SBO:0000176
fast: false
name: adenylate kinase (d form)
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_274f2364_068c_48a4_b90b_f14437954804
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGKQ
is encoded by: hsa:1609
constant: false
is: P52824

metaR GHMT2r
is: SBO:0000176
name: glycine hydroxymethyltransferase, reversible
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

metaM icit c
initial amount: NaN
is: C00311
name: Isocitrate
is: SBO:0000247
is: HMDB00193
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16087
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR DPCOAPPe
kinetic law: MODEL1310110031#
fast: false
type: Reaction
product: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
name: Pyrophasphatase (dephospho-CoA, extracellular)
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_83645701_7b2f_4d7d_b9e4_9e72e759f823
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:11136
is: P82251
name: SLC7A9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e4fd0286_b837_409d_ac39_d7c259208dfb
name: DHCR24
is: SBO:0000252
is: Q15392
is encoded by: hsa:1718
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR RE0944E
modifier: MODEL1310110031#
name: RE0944
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaM ru5p D r
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00618
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
type: Species

metaM ksi pre5 g
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C101H164N7O75SX CHARGE: -2
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 5

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
is: CHEBI:15698
is: SBO:0000247
is: HMDB00014
initial concentration: 1.0
boundary condition: false
constant: false
is: C00881
initial amount: NaN
name: Deoxycytidine
has only substance units: false

metaR r1632
is described by: ECO:0000000
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110031#

metaR SPMTDe
is: SBO:0000185
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: SPMTDe
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2387d3ea_af05_4aa9_b405_7578153727b8
is: Q7GXZ8
name: COX2
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4513
initial concentration: NaN

metaR r1592
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110031#

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185

metaM o2 r
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01377
is: CHEBI:15379
is: C00007
name: O2
constant: false
is: SBO:0000247

metaM acetone e
is: HMDB01659
name: acetone
constant: false
is: CHEBI:15347
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial concentration: 1.0

metaM n2m2nmasn e
is: C04946
boundary condition: false
constant: false
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_cb3ca609_a2fd_4602_8892_48d602bf1b48
name: DOLPP1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:57171
is: Q86YN1
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_ee25e85e_744b_4cf8_9677_830cecc45e50
initial concentration: NaN
is encoded by: hsa:9194
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC16A7
is: Q8NEM3
type: Species
constant: false
has only substance units: false

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_b67e873e_88d1_4341_93dd_a2e1bf01eb7d
initial amount: NaN
is: SBO:0000252
name: _BE042354_1_m
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:BE042354

metaR r1631
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_8c19224b_30ba_4907_95c9_d4d2b60bfc0f
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: PANK3
is: SBO:0000252
is encoded by: hsa:79646
initial concentration: NaN
is: Q9H999

http://identifiers.org/biomodels.db/MODEL1310110031#_36f7894e_75f7_4a9c_bca7_548c29cbe347
constant: false
is: Q9Y2C5
name: SLC17A4
type: Species
initial amount: NaN
is encoded by: hsa:10050
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM lys L e
type: Species
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
is: CHEBI:32551
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00182
initial concentration: 1.0

metaM gua e
name: guanine
is: HMDB00132
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0

metaR HESTRATRIOLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
name: hydroxylated estrogen derivative transport
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM lnlncgcoa r
is: HMDB06368
has only substance units: false
is: CHEBI:57363
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a69b66f8_f667_4cfe_8dbf_27b1db4ed253
boundary condition: true
initial amount: NaN
name: DGKZ
is: B7Z6M3
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8525

metaR r1591
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false

metaR r2116
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true

metaR DOLPGT1 Uer
is version of: http://identifiers.org/ec-code/2.4.1.267
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reversible: false
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_fec110d6_8d6b_4106_971b_a5ccae1d7c38
initial amount: NaN
name: GPX5
is encoded by: hsa:2880
constant: false
is: SBO:0000252
boundary condition: true
is: O75715
type: Species
has only substance units: false
initial concentration: NaN

metaR FAOXC15ATPx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaM tmndnc c
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01999
is: http://identifiers.org/pubchem.compound/446284
name: timnodonic acid C20:5, n-3

metaR C4CRNCPT2
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM chol e
constant: false
boundary condition: false
type: Species
is: HMDB00097
initial amount: NaN
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Choline
is: CHEBI:15354

metaR r1630
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
fast: false

metaM naglc2p L c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
has only substance units: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
type: Species
is: CHEBI:18278

metaM acac c
type: Species
is: SBO:0000247
name: acetoacetate
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00060
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705

metaR S4TASE5ly
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

metaR r1610
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000

metaR HISD
fast: false
is: SBO:0000176
name: histidase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.3.1.3
kinetic law: MODEL1310110031#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_66b3b847_3b08_4b03_9f84_1bb986e1c351
is: P25092
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2984
initial amount: NaN
boundary condition: true
name: GUCY2C
initial concentration: NaN

metaR C102CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR r2124
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110031#
type: Reaction
fast: false

metaM nm2masn g
constant: false
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
has only substance units: false
initial concentration: 1.0
is: C05884
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C42H70N3O30X CHARGE: 0

metaM glu L m
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
has only substance units: false
is: HMDB00148
is: SBO:0000247
name: L-glutamate(1-)
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR B3GNT11g
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000269

metaR RE0958E
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_8b6e4542_6715_467a_986e_4ec6cdb6ef99
type: Species
is: SBO:0000252
name: CLYBL
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:171425
constant: false
boundary condition: true
has only substance units: false

metaM idp n
has only substance units: false
name: IDP(3-)
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: CHEBI:58280
initial concentration: 1.0
initial amount: NaN

metaM ksi deg31 l
is: SBO:0000247
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
constant: false
is: HMDB01354
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 31
is: CHEBI:57455
initial amount: NaN
type: Species

metaR r1611
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE2434 m
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57795
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false

metaR r2123
reactant: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction

metaR C6DCCACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_e1695567_e052_40c7_9204_27419d0fe8b0
is encoded by: hsa:54344
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q86TM7
name: DPM3
initial amount: NaN
constant: false

metaM gbside hs l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
name: globoside
initial amount: NaN
constant: false
type: Species
is: CHEBI:18259

http://identifiers.org/biomodels.db/MODEL1310110031#_68d07c0a_c350_4533_9bd1_91900fa122a7
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: _NOS2A_1_c
is encoded by: hsa:NOS2A
has only substance units: false
type: Species
is: SBO:0000252

metaM tetde5coa x
type: Species
name: 5-tetradecenoylcoa
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: HMDB13109
constant: false
initial concentration: 1.0
initial amount: NaN

metaM ctp c
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00063
is: HMDB00082
type: Species
boundary condition: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e0eaa5f5_7f45_4aaa_bcde_bb4a337b4b6b
type: Species
initial amount: NaN
is encoded by: hsa:2629
is: B7Z5G2
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110031#_3e276b45_bed1_4262_8dbd_4ab0618e35b2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: G3XAJ0
boundary condition: true
constant: false
is encoded by: hsa:80724
type: Species
has only substance units: false
name: ACAD10

http://identifiers.org/biomodels.db/MODEL1310110031#_781d7f89_0b65_4feb_a651_ea5eee6b62cc
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: AGPAT4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56895
is: Q9NRZ5

metaR S6TASE26ly
fast: false
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r2122
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110031#
reversible: true

metaM fuc L c
has only substance units: false
initial concentration: 1.0
is: CHEBI:18287
constant: false
type: Species
is: HMDB00174
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR AASAD3m
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
fast: false
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
product: MODEL1310110031#
reversible: false
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15865210 NOTES:MM. Found under reaction synonym name: 2-aminoadipic 6-semialdehyde dehydrogenase; Evidence was from mouse with identification of good human ortholog for U26 in the mouse that catalyzes this reaction. There was NOT evidence here specific to mitochondria, though. (Nathan Price)

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
kinetic law: MODEL1310110031#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is: SBO:0000185

metaR r1612
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
fast: false

metaM fol c
type: Species
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
constant: false
name: Folate
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_77c36d94_abb8_4395_a9e2_78737e4092a3
is encoded by: hsa:4166
constant: false
is: Q9GZX3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: CHST6

http://identifiers.org/biomodels.db/MODEL1310110031#_69270394_dc92_48f8_9088_06dd5880202e
is encoded by: hsa:AI684467
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: _AI684467_1_m

metaR IPDDIx
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.2
is described by: ECO:0000134
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reactant: MODEL1310110031#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR LTA4H
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.3.2.6
modifier: MODEL1310110031#
is: SBO:0000176
fast: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
product: MODEL1310110031#
name: Leukotriene A-4 hydrolase
reversible: false

metaR GMPtg
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
reversible: true
name: GMP transport (Golgi)
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_00ef56e1_18dc_4499_9349_cf22deccd46e
type: Species
has only substance units: false
name: _W87865_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:W87865

metaM 4ppcys c
type: Species
is: C04352
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: CHEBI:59458
is: HMDB01117
constant: false

metaR r2121
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_7efdc14b_fd35_48a5_a381_f14bc5972a69
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AV727634
boundary condition: true
initial concentration: NaN
name: _AV727634_1_c

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM pnto R e
is: CHEBI:7916
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
has only substance units: false
name: (R)-Pantothenate
is: HMDB00210
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_3b9bdd34_517a_466d_9131_ad258c61d3af
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN
is: Q96L53

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000

metaM ksii core4 deg1 l
initial concentration: 1.0
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 1
is: CHEBI:57737
constant: false
is: HMDB00868
has only substance units: false
initial amount: NaN

metaR CO2ter
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
name: CO2 endoplasmic reticular transport via diffusion
fast: false
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM ctp e
boundary condition: false
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00082
is: CHEBI:37563
has only substance units: false
type: Species
initial amount: NaN

metaM acetone c
is: SBO:0000247
constant: false
initial amount: NaN
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
is: CHEBI:15347
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_d3d4e46a_98e3_44c4_b11a_34dfcee16bb5
is: P11310
constant: false
name: ACADM
is encoded by: hsa:34
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM 3octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
constant: false
initial concentration: 1.0
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
type: Species

metaM hdca l
boundary condition: false
initial amount: NaN
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
initial concentration: 1.0
is: HMDB00220
name: palmitate
is: SBO:0000247
constant: false
type: Species

metaM n2m2nmn l
notes: FORMULA: C50H84N4O36 CHARGE: 0
type: Species
is: CHEBI:36655
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
boundary condition: false
is: HMDB00119
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR BHBtm
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false

metaR r1614
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b13023d4_2614_4788_a74c_f5c841e091db
has only substance units: false
is: Q8IUC8
constant: false
type: Species
name: GALNT13
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:114805

metaR SEBACACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM fuc L e
boundary condition: false
is: CHEBI:18287
type: Species
constant: false
has only substance units: false
is: HMDB00174
name: L-fucose
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247

metaR r2120
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1020
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_4aeb51cd_c1b1_462f_822d_0dcd23dd5e70
is: SBO:0000252
is encoded by: hsa:224
name: ALDH3A2
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110031#_60b2413b_42a9_40b3_adba_10a498f1a754
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: CHST3
is: Q7LGC8
is: SBO:0000252
is encoded by: hsa:9469
constant: false
type: Species

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
fast: false
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
reversible: true
product: MODEL1310110031#

metaM fol e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: Folate

metaM l2fn2m2masn g
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C68H113N4O49X CHARGE: 0
type: Species
is: CHEBI:28067
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
has only substance units: false

metaR C4STMO2Pr
modifier: MODEL1310110031#
name: C-4 methyl sterol oxidase
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000

metaM C05965 e
is: CHEBI:57444
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB04243
is: SBO:0000247
initial concentration: 1.0
name: 12(S)-HPETE(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965

metaR r1615
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185

metaR GLCNACPT U
reactant: MODEL1310110031#
is: SBO:0000176
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.15
product: MODEL1310110031#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM 4abutn m
initial concentration: 1.0
is: SBO:0000247
name: 4-ammoniobutanal
constant: false
is: CHEBI:58264
has only substance units: false
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
initial amount: NaN
boundary condition: false

metaR AG13T13g
modifier: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110031#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_122036a3_8b1f_484b_a779_338c6230cfe2
is encoded by: hsa:522
name: ATP5J
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR BILDGLCURt
kinetic law: MODEL1310110031#
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_f8ef436a_195c_497b_9a0b_c4a89899f2e4
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2544
name: _2544_1_c
type: Species
initial amount: NaN

metaM ksi deg5 l
is: CHEBI:12936
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: HMDB00143
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 5
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1e29af3f_0449_4e70_bc1d_d83f0ea8b43b
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: _NM_013421_1_e
is encoded by: hsa:NM 013421
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_22238af3_76ee_4329_bfa2_62eb749cd07e
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2181
initial amount: NaN
name: ACSL3
boundary condition: true
is: O95573
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_c2f758d4_56b8_4449_98a5_610f4b8e17c6
boundary condition: true
has only substance units: false
is encoded by: hsa:6319
is: O00767
constant: false
name: SCD
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaR NADNe
is version of: http://identifiers.org/ec-code/3.2.2.5
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
is described by: ECO:0000269
name: NAD nucleosidase,extracellular
kinetic law: MODEL1310110031#
reversible: false
is: SBO:0000176
reactant: MODEL1310110031#
fast: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_ba215c38_6713_4ec0_8d04_be6d5b246a2a
type: Species
constant: false
initial concentration: NaN
name: CYP51A1
is encoded by: hsa:1595
initial amount: NaN
is: SBO:0000252
is: Q16850
boundary condition: true
has only substance units: false

metaR r1616
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110031#
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM adpcoa x
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB04047
is: SBO:0000247
constant: false
boundary condition: false
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
has only substance units: false

metaM no e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
is: CHEBI:16480
constant: false
initial amount: NaN
is: HMDB03378
type: Species
has only substance units: false
name: Nitric oxide
is: C00533

metaR XOL7AH2tm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185

metaR PItg
is: SBO:0000185
product: MODEL1310110031#
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110031#

metaM Ser Thr g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
has only substance units: false
type: Species
is: CHEBI:58336
notes: FORMULA: XH CHARGE: 0
is: HMDB00645

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_8272c271_d712_405d_8ae1_43000d10e101
type: Species
initial amount: NaN
is: Q9UBY0
has only substance units: false
constant: false
initial concentration: NaN
name: SLC9A2
is encoded by: hsa:6549
boundary condition: true
is: SBO:0000252

metaR DMHPTCRNCPT2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
name: 2,6 dimethylheptanoly CoA carnitine transferase
kinetic law: MODEL1310110031#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_ce2a7c4e_a54d_4ef9_bb41_a4d4090a4516
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:51301
is: SBO:0000252
has only substance units: false
is: Q9P109
initial concentration: NaN
name: GCNT4

metaM dhlam m
is: HMDB00985
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17694
name: dihydrolipoamide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1034d4bd_9f89_48dc_a944_2f3c53766a30
is: Q9NP56
is encoded by: hsa:27115
constant: false
name: PDE7B
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaM retinal cis 9 c
has only substance units: false
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
is: SBO:0000247
type: Species
name: all-trans-retinal
is: HMDB01358
constant: false
initial amount: NaN
initial concentration: 1.0

metaR C12DCACOT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR r1617
product: MODEL1310110031#
type: Reaction
fast: false
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110031#

metaR r0698
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reversible: true
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000176
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.27

metaR UROLACer
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
name: uronolactonase, endoplasmic reticulum
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
reversible: true

metaM ksi deg18 l
boundary condition: false
name: keratan sulfate I, degradation product 18
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00143
constant: false
is: SBO:0000247
is: CHEBI:12936

metaR APOCFm
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
name: Apocarboxylase formation, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
kinetic law: MODEL1310110031#

metaM 3ivcoa m
type: Species
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: C05998
is: HMDB06870
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxyisovalerylcoa
initial concentration: 1.0

metaM 3hddcoa m
type: Species
is: C05279
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB11123
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_e469a330_d847_4a3f_b63c_1e51eb77286e
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
initial amount: NaN
name: PDE9A

metaR ENGASEly
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176

metaM hx2coa x
is: http://identifiers.org/pubchem.compound/11966188
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: trans-Hex-2-enoyl-CoA
initial concentration: 1.0
is: HMDB06870
boundary condition: false
initial amount: NaN
is: C05998
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaR GULNDer
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
reversible: true
product: MODEL1310110031#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
name: gulonate dehydrogenase, endoplasmic reticulum

metaM hs deg12 l
is: HMDB06210
initial concentration: 1.0
name: heparan sulfate, degradation product 12
boundary condition: false
is: SBO:0000247
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR ALAGLNNaEx
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is: SBO:0000185
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)

http://identifiers.org/biomodels.db/MODEL1310110031#_b7afa755_b890_4051_b9cc_bd36b9648390
initial concentration: NaN
is: B3KNC1
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: UPB1
constant: false
is encoded by: hsa:51733

metaR KDNH
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
fast: false
name: 2-keto-3deoxy-D-glycero-D-galactononic acid phosphohydrolase
type: Reaction
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM gbside hs c
has only substance units: false
constant: false
is: CHEBI:18259
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
boundary condition: false
type: Species

metaM taur c
is: CHEBI:3544
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
type: Species
is: HMDB00251
is: C00245
name: Taurine

metaR RE1898C
reversible: true
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110031#
name: RE1898
fast: false
is described by: ECO:0000000

metaM chito2pdol U c
is: CHEBI:12427
type: Species
constant: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false

metaR r1177
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
name: EC:3.1.1.13
product: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is described by: ECO:0000000

metaR r1618
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM no c
is: HMDB03378
is: CHEBI:16480
has only substance units: false
type: Species
initial amount: NaN
is: C00533
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
name: Nitric oxide
initial concentration: 1.0
constant: false

metaR ADK1
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
is: SBO:0000176
name: adenylate kinase
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_5173274a_0263_4d09_b86a_f09bf93507e7
boundary condition: true
type: Species
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM g1p c
is: C00103
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: HMDB01586
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: D-Glucose 1-phosphate
is: CHEBI:58601
type: Species
initial amount: NaN

metaM gthox e
initial concentration: 1.0
has only substance units: false
is: HMDB03337
is: SBO:0000247
constant: false
is: CHEBI:58297
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species

metaM gly m
is: CHEBI:15428
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
has only substance units: false
boundary condition: false
name: Glycine
initial amount: NaN
is: C00037
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_be76ad24_ce49_47ac_bcc3_dbf815ca0f0b
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
is: P28329

http://identifiers.org/biomodels.db/MODEL1310110031#_102b8ca0_a494_4597_b778_bb0849ca67b2
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: PDE6B
has only substance units: false
boundary condition: true
is encoded by: hsa:5158
is: B7Z9T9
initial amount: NaN

metaM 34dhoxpeg e
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00318
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7902
has only substance units: false
is: C05576
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: SBO:0000247
name: 3,4-Dihydroxyphenylethyleneglycol

metaR FAOXC61C4x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR r1619
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_7acae34b_b3b1_42b9_8398_4c0ce77b99bb
has only substance units: false
is: P11182
is: SBO:0000252
boundary condition: true
name: DBT
constant: false
is encoded by: hsa:1629
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_5f22f481_1371_4e46_9e4d_edb3da0b8351
is: SBO:0000252
name: GGT5
boundary condition: true
is encoded by: hsa:2687
type: Species
constant: false
is: P36269
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_fff5e329_13f5_4c74_9b3d_22d25fb966c2
is: Q8N3T1
is: SBO:0000252
name: GALNTL2
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:117248
initial amount: NaN
has only substance units: false

metaM 4ppcys m
initial concentration: 1.0
initial amount: NaN
type: Species
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: CHEBI:59458
boundary condition: false
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117
is: SBO:0000247
constant: false

metaM fuc L l
initial amount: NaN
name: L-fucose
initial concentration: 1.0
is: CHEBI:18287
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR r2401
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
product: MODEL1310110031#
is: SBO:0000185

metaM taur e
is: SBO:0000247
is: CHEBI:3544
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: C00245
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine

metaM gbside hs e
is: CHEBI:18259
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
boundary condition: false
name: globoside
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ec3030bc_dd19_44ee_aa47_3065eb6036bb
has only substance units: false
is: A0S0A7
boundary condition: true
constant: false
is encoded by: hsa:4846
initial amount: NaN
name: NOS3
type: Species
is: SBO:0000252
initial concentration: NaN

metaR C8CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

metaR PNTOte
is described by: ECO:0000134
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110031#
fast: false
reversible: true
is: SBO:0000185
name: Transport of (R)-Pantothenate
reactant: MODEL1310110031#

metaM Ser Thr l
initial concentration: 1.0
constant: false
type: Species
is: HMDB00425
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false
boundary condition: false

metaM m2emgacpail hs r
has only substance units: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
constant: false
is: C00080
initial amount: NaN
boundary condition: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110031#_e197cf2d_7d2e_48a6_9bc2_22389cc46f38
is: SBO:0000252
boundary condition: true
is: P32321
is encoded by: hsa:1635
name: DCTD
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR DLNLCGCRNt
product: MODEL1310110031#
is: SBO:0000185
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110031#
name: transport into the mitochondria (carnitine)

metaM sucsal m
name: Succinic semialdehyde
has only substance units: false
initial concentration: 1.0
is: HMDB01259
constant: false
is: CHEBI:57706
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bbc61135_cf31_4827_bec9_5fc8820e1219
boundary condition: true
initial amount: NaN
is encoded by: hsa:195814
is: SBO:0000252
constant: false
is: B3KT84
has only substance units: false
name: SDR16C5
type: Species
initial concentration: NaN

metaR ANTHte
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of anthranilate
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
fast: false

metaM 34dhoxpeg c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00318
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
is: http://identifiers.org/pubchem.compound/7902
name: 3,4-Dihydroxyphenylethyleneglycol
is: C05576

metaR HEXDICOAACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_730098dd_5bfc_4601_8fd2_8e2c2fd7ec63
is: F5GWS5
constant: false
is encoded by: hsa:55811
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ADCY10
type: Species
initial amount: NaN

metaM sebcoa x
initial concentration: 1.0
name: sebacoylcoa
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
type: Species

metaR H2Otly
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110031#_7057894a_7955_46f5_9f6a_197c1013a062
has part: P48736
is encoded by: hsa:10870
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5294
has part: Q9UBK5
constant: false
is: SBO:0000297
type: Species
has only substance units: false
name: HCST:PIK3CG

metaM dc2coa x
initial amount: NaN
is: HMDB01168
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
constant: false
type: Species

metaM thbpt c
is: HMDB00027
type: Species
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
constant: false
is: CHEBI:15372

http://identifiers.org/biomodels.db/MODEL1310110031#_e83ead96_fd5c_4414_b9cb_224aa7d45f19
is: P30049
type: Species
has only substance units: false
constant: false
name: ATP5D
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:513
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_b26cae44_c15e_4129_af59_e58a3b7a7d5d
has only substance units: false
is: P05091
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ALDH2
initial concentration: NaN
is encoded by: hsa:217
constant: false

metaR RE2954C
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: true
reactant: MODEL1310110031#
name: RE2954
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f020dc8c_8e58_4b39_a89f_db64504dbb20
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5167
boundary condition: true
is: SBO:0000252
is: P22413
constant: false
name: ENPP1
has only substance units: false

metaR S6TASE24ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true

metaM gbside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
constant: false
name: globoside
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_9a3771ee_a883_406f_8772_216eb43a75c4
constant: false
is encoded by: hsa:1468
initial amount: NaN
initial concentration: NaN
name: SLC25A10
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q9UBX3

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaR GLCURtly
reversible: true
is described by: ECO:0000269
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
fast: false
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e2d58525_3e5c_4fb7_a3fb_593ec3606803
constant: false
is encoded by: hsa:51227
boundary condition: true
has only substance units: false
initial amount: NaN
name: PIGP
is: SBO:0000252
is: P57054
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_0fdca983_6484_4f35_9434_3621ec40b543
initial amount: NaN
name: ADCY5
constant: false
has only substance units: false
is: SBO:0000252
is: O95622
initial concentration: NaN
is encoded by: hsa:111
type: Species
boundary condition: true

metaR MI1P Dtn
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: inositol 1-phosphate nuclear transport (diffusion)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_117c7157_fcf8_4871_a1e0_ac851e9872d3
is: SBO:0000252
name: _AI620219_1_e
initial concentration: NaN
constant: false
is encoded by: hsa:AI620219
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR C14STRr
name: C-14 sterol reductase
is described by: ECO:0000134
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: false
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_426364a2_8232_4e2b_8704_6b5d1afc6921
is encoded by: hsa:2876
is: SBO:0000252
name: GPX1
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM chito2pdol L c
is: CHEBI:12427
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
initial concentration: 1.0
has only substance units: false
is: HMDB01196
boundary condition: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaM crn c
name: L-Carnitine
initial concentration: 1.0
constant: false
boundary condition: false
is: C00318
has only substance units: false
initial amount: NaN
is: CHEBI:16347
type: Species
is: HMDB00062
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110031#_1c13ad6a_c888_45b7_8465_6cf89d97c724
is: O14939
type: Species
name: PLD2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5338
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM rbt e
name: D-ribitol
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
constant: false
is: HMDB00508
type: Species
is: CHEBI:15963
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM HC01403 m
boundary condition: false
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28325
initial amount: NaN

metaM hdca r
initial concentration: 1.0
is: C00249
is: HMDB00220
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896
constant: false
name: Hexadecanoate (n-C16:0)

http://identifiers.org/biomodels.db/MODEL1310110031#_58f1ed65_94d4_4b78_ae11_2d8013f2348d
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:204
name: AK2
type: Species
is: P54819
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM fadh2 m
initial amount: NaN
is: SBO:0000247
name: Flavin adenine dinucleotide reduced
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58307
initial concentration: 1.0
is: HMDB01197
constant: false

metaM hs deg2 l
initial amount: NaN
initial concentration: 1.0
is: HMDB06210
has only substance units: false
boundary condition: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
type: Species
is: SBO:0000247
name: heparan sulfate, degradation product 2
constant: false

metaM dgtp n
is: C00286
name: dGTP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01440
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: CHEBI:16497

metaM CE1926 e
constant: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00127
boundary condition: false
name: gama-carboxyethyl-hydroxychroman
initial amount: NaN
is: CHEBI:15748

metaM btcoa x
is: HMDB01088
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
name: Butanoyl-CoA
type: Species
is: C00136
has only substance units: false
constant: false

metaM dhcholestanate c
has only substance units: false
constant: false
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
is: HMDB00359
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR SIAT4Bg
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reactant: MODEL1310110031#

metaR 34DHPHEt
name: 3,4-Dihydroxy-L-phenylalanine transport
is described by: ECO:0000269
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#

metaM 3octdectecoa m
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
type: Species
has only substance units: false

metaM ksii core2 deg4 l
constant: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1
is: HMDB01354
name: keratan sulfate II (core 2-linked), degradation product 4
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57455
boundary condition: false
initial concentration: 1.0
type: Species

metaM gthox c
is: HMDB03337
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: CHEBI:58297
initial amount: NaN
name: Oxidized glutathione
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
is: C00127

metaM o2 c
initial concentration: 1.0
boundary condition: false
type: Species
name: O2
constant: false
is: HMDB01377
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
is: C00007
has only substance units: false

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
fast: false
name: adentylate kinase (GTP)
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR

metaR r2404
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR FAOXTC102C101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM coucoa m
type: Species
is: CHEBI:57355
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: C00223
initial concentration: 1.0
name: 4-coumaroyl-CoA(4-)
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: lipoamide
is: HMDB00962
is: CHEBI:17460
has only substance units: false
type: Species
constant: false

metaR CYTK10n
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
name: cytidylate kinase (CMP,dGTP),nuclear

metaM rbt c
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00508
type: Species
is: CHEBI:15963
name: D-ribitol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_92dbf7c9_7e00_4d02_b86b_8f5844380e3e
boundary condition: true
has part: P56134
is: SBO:0000297
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522

metaR SUCCt4 2
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
name: succinate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
kinetic law: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_f7690989_27a7_46ac_90b9_0758628e8d17
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9H2U2
type: Species
is: SBO:0000252
name: PPA2
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110031#_12303f57_4330_41b1_b750_8bb21fd255c0
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q96G03
name: PGM2
type: Species
is encoded by: hsa:55276

metaR LAPCOAl
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
modifier: MODEL1310110031#
reversible: false
product: MODEL1310110031#
is described by: ECO:0000304
name: lysosomal acid phosphorylase (CoA)
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM acgam6p c
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: SBO:0000247
is: CHEBI:57513
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR 3DSPHR
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110031#
name: 3-Dehydrosphinganine reductase
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.102
is: SBO:0000176
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_d68bd99f_4fef_494a_8587_85034c1fa6e0
boundary condition: true
name: PRPS1L1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:221823
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_973412f1_98bf_4c00_80b7_8b010103cbd2
initial concentration: NaN
name: TK2
has only substance units: false
is encoded by: hsa:7084
is: SBO:0000252
is: O00142
constant: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_b0cc3dfa_adaa_4c2b_8dc0_7d1e7b9a1d24
name: SGPL1
type: Species
is: SBO:0000252
is: O95470
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8879
has only substance units: false
initial amount: NaN

metaR RE3243R
name: RE3243
is: SBO:0000176
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110031#

metaM 4mzym int1 r
is: SBO:0000247
name: 4-Methylzymosterol intermediate 1
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false
is: HMDB06927
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_781c86e1_c3ea_4fdd_ad6e_8d85f421b5c1
constant: false
has only substance units: false
name: PPAT
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:5471
is: Q06203
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_5eba5177_5687_4ec8_84c4_7042e60f37d0
is encoded by: hsa:79646
constant: false
initial amount: NaN
name: PANK3
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q9H999
is: SBO:0000252

metaR DHCR72r
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110031#
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110031#
name: 7-dehydrocholesterol reductase
is: SBO:0000176
kinetic law: MODEL1310110031#

metaM ppa e
is: CHEBI:17272
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
name: propionate
initial amount: NaN
is: HMDB00237
type: Species
boundary condition: false

metaR r0354
type: Reaction
kinetic law: MODEL1310110031#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_8e7cecb9_e106_478e_817b_acedaec03089
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P04062
name: GBA
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2629

metaR COAtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110031#
type: Reaction
reversible: true

metaR r0249
reactant: MODEL1310110031#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b5030351_8606_4625_80c0_7c9ad4eb2e63
initial amount: NaN
has only substance units: false
constant: false
is: Q4W5N8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:51166
name: AADAT

http://identifiers.org/biomodels.db/MODEL1310110031#_d9a711b8_b456_4767_a476_1c055efbef41
is encoded by: hsa:4668
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: NAGA
is: P17050
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_cad21d00_a192_4cfb_a604_69f24432d85f
name: SDHD
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6392
boundary condition: true
is: O14521
has only substance units: false
is: SBO:0000252

metaM prpp c
is: HMDB00280
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58017
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
is: C00119

metaR G5SDym
is version of: http://identifiers.org/ec-code/1.2.1.41
is: SBO:0000176
reactant: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
name: glutamate-5-semialdehyde dehydrogenase (m)
fast: false
is described by: ECO:0000254
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_21ad4f01_8640_482b_ba65_6068d2ae813e
name: ATP1A3:ATP1B1
has part: A3KLL5
constant: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:481
type: Species
has only substance units: false
is encoded by: hsa:478
has part: B7Z2T0
initial amount: NaN
initial concentration: NaN

metaR TSTSTERONESte
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: sulfonated testosterone transport
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
reversible: true
is: SBO:0000185

metaR EHGLAT2m
reactant: MODEL1310110031#
is described by: ECO:0000304
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r0246
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaM crn e
is: CHEBI:16347
is: C00318
type: Species
has only substance units: false
initial concentration: 1.0
name: L-Carnitine
boundary condition: false
is: SBO:0000247
is: HMDB00062
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN

metaR GUAt
name: Guanine transport
is described by: ECO:0000269
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
product: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_41cf96cb_f772_4ca0_be89_e66aaeaa0745
boundary condition: true
has only substance units: false
is encoded by: hsa:3000
is: SBO:0000252
is: Q02846
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: GUCY2D

http://identifiers.org/biomodels.db/MODEL1310110031#_80ea39ad_c4f9_4fef_b4fa_04992f9f1830
is: Q6I9V2
is encoded by: hsa:509
name: ATP5C1
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_499df1da_5c05_4304_8985_b6063eb83810
type: Species
initial concentration: NaN
is: P38571
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: LIPA
is encoded by: hsa:3988
has only substance units: false

metaR PRO Dtde
fast: false
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000134
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
type: Reaction

metaM galgalthcrm hs g
initial amount: NaN
type: Species
is: CHEBI:26174
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Gal-Gal-Gal-Gal-Glc-Cer
constant: false
boundary condition: false
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0

metaM srtn e
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00259
is: SBO:0000247
boundary condition: false

metaM cs a l
constant: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB02183
initial amount: NaN
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
has only substance units: false
type: Species
is: SBO:0000247

metaR BTNPLm
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
modifier: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial

metaR UGLT
modifier: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
reversible: true
is: SBO:0000176
type: Reaction

metaM tetdecdicoa x
type: Species
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0
is: SBO:0000247
is: HMDB02288
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
has only substance units: false

metaM 3ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 3,6-dodecadienoylcoa
is: C05280
initial amount: NaN
constant: false
has only substance units: false
is: HMDB03952
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM ppa c
type: Species
is: HMDB00237
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r1492
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c2cc5984_4105_4a7a_91f8_c77b7fdead28
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9023
is: O95992
name: CH25H
initial concentration: NaN

metaM adpcoa c
initial amount: NaN
is: C14143
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB04047
boundary condition: false
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110031#_824bf3f0_52cb_415c_b8e5_37f10c540145
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5279
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: PIGC

metaR FAOXC185C164m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR G14T13g
modifier: MODEL1310110031#
reversible: false
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110031#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000

metaR FAOXC61C4m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR SADT
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
product: MODEL1310110031#
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_7354e04f_97a9_45f1_b689_117593247d2c
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10164
name: CHST4
is: Q8NCG5
boundary condition: true

metaR FAOXC204184m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR HPDCACRNt
is described by: ECO:0000269
name: heptadecanoate transport into the mitochondria
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
reversible: false

metaR LEUATB0tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Leucine into the intestinal cells by ATB0 transporter
type: Reaction

metaR TREHe
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is described by: ECO:0000269
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110031#

metaR URAt
modifier: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
reversible: true
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269

metaM tdcoa m
is: CHEBI:57385
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
type: Species
is: C02593

http://identifiers.org/biomodels.db/MODEL1310110031#_37f6ca4e_5281_4286_a97c_c8984a842a83
has only substance units: false
initial amount: NaN
name: ACOT7
is: O00154
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:11332
boundary condition: true
is: SBO:0000252

metaR 4HBZFm
name: 4-hydroxybenzoate formation
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is: SBO:0000176
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_9fbe39d7_3e27_41a7_a310_551af7ede9de
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2643
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q8IZH9
name: GCH1

metaM srtn c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546
name: serotonin(1+)
initial amount: NaN
is: HMDB00259
has only substance units: false

metaM 4hexdtetcoa m
is: SBO:0000247
initial concentration: 1.0
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
type: Species

metaR PIPLCn
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C, nucleus
is: SBO:0000176
modifier: MODEL1310110031#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c072a646_2895_4a25_b8b1_fa3dd2572b08
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q9NY65
initial amount: NaN
name: EHHADH
is encoded by: hsa:1962

http://identifiers.org/biomodels.db/MODEL1310110031#_bee02a47_88d8_4108_9efd_ab748476df32
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:2639
type: Species
initial amount: NaN
name: GCDH
initial concentration: NaN
is: Q92947
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_88424cb1_1a4f_4202_b4e5_f41f1bc71f28
is: SBO:0000252
is encoded by: hsa:229
has only substance units: false
is: P05062
constant: false
type: Species
initial amount: NaN
name: ALDOB
boundary condition: true
initial concentration: NaN

metaM cs e deg2 l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57455
is: HMDB01354
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2

metaR EX decdicrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaM dhcholestanate m
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00359
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16577
initial concentration: 1.0

metaR 3MLDAt
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
name: 3MLDA extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
product: MODEL1310110031#
reversible: true
type: Reaction

metaR OCCOAtx
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#
name: fatty acid intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

metaR Rtotaltl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110031#
name: fatty acid intracellular transport
type: Reaction
reactant: MODEL1310110031#
reversible: true

metaR COAtn
type: Reaction
name: coenzyme A transport, nuclear
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110031#
reactant: MODEL1310110031#

metaM crn m
boundary condition: false
type: Species
is: C00318
has only substance units: false
initial amount: NaN
is: CHEBI:16347
constant: false
initial concentration: 1.0
is: HMDB00062
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine

metaR DHCHOLESTANATEtm
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#

metaR RTOTAL2t
fast: false
name: RTOTAL2 transport
reversible: true
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185

metaR S6T4g
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176

metaR FAOXTC142TC122m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR MM7B2g
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#

metaR EX c51crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4ee8aace_5008_4f44_9ef4_d5c357e23832
initial amount: NaN
is encoded by: hsa:3038
constant: false
is: SBO:0000252
name: HAS3
has only substance units: false
is: O00219
type: Species
boundary condition: true
initial concentration: NaN

metaM fadh2 x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58307
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: HMDB01197
name: FADH2(2-)
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_73ddc83f_5249_41c9_b2d2_4dfbd5c7a1e6
is encoded by: hsa:1809
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q8IXW6
constant: false
initial amount: NaN
type: Species
name: DPYSL3

metaR PRO1x
reactant: MODEL1310110031#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000134
type: Reaction
name: L-ProlineNAD+ 5-oxidoreductase
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_926024cb_fd60_4337_8759_73afa98edca4
boundary condition: true
name: SLC27A5
is: SBO:0000252
constant: false
is: Q9Y2P5
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10998
type: Species

metaM m6masnB2 g
type: Species
boundary condition: false
is: CHEBI:50570
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06529

metaR O2ter
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6b0c6e10_34c9_475c_b39f_b6d97017c114
has part: E9PDD5
type: Species
has part: P50213
is encoded by: hsa:3421
constant: false
is encoded by: hsa:3419
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3420
is: SBO:0000297
has only substance units: false
name: IDH3A:IDH3B:IDH3G

metaR ME2m
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is: SBO:0000176
type: Reaction
name: malic enzyme (NADP), mitochondrial
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.40

metaR GHMT2rm
reversible: true
product: MODEL1310110031#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.1

metaR MMMm
reactant: MODEL1310110031#
name: methylmalonyl-CoA mutase
is version of: http://identifiers.org/ec-code/5.4.99.2
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
reversible: true
is described by: ECO:0000269
type: Reaction

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_af054503_3db7_4c46_9fa8_fbfe9c1605fc
is: D3DX95
is encoded by: hsa:1103
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
name: CHAT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_39e6ea46_fc08_4e60_9e37_f31eda441b49
has part: Q6IB04
type: Species
has only substance units: false
is encoded by: hsa:5281
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:84720
constant: false
name: PIGF:PIGO

metaR C161CRNt
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
type: Reaction
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: C161 transport into the mitochondria

metaM prpp e
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: HMDB00280
initial concentration: 1.0
initial amount: NaN
constant: false

metaR C142ACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR GALASE7ly
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR COAtp
type: Reaction
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_beeb840a_2e7d_4079_8294_1443e4d64fe4
has only substance units: false
constant: false
type: Species
is: B3KUV7
initial concentration: NaN
boundary condition: true
name: PIGA
is encoded by: hsa:5277
is: SBO:0000252
initial amount: NaN

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR P45011A1m
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
is version of: http://identifiers.org/ec-code/1.14.15.6
reversible: false
name: Cytochrome P450 11A1, mitochondrial [Precursor]
modifier: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_242f6d7b_e698_4792_8cfa_fe3343231573
has only substance units: false
is encoded by: hsa:217
initial concentration: NaN
initial amount: NaN
constant: false
is: P05091
name: ALDH2
boundary condition: true
is: SBO:0000252
type: Species

metaR GLCNACASE1ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
fast: false
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110031#

metaR RE3381E
reversible: true
reactant: MODEL1310110031#
name: RE3381
modifier: MODEL1310110031#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110031#_3f3e9c16_78e4_45e6_93ce_df8a4cab2b00
is: SBO:0000252
has only substance units: false
name: ST3GAL3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6487
type: Species
constant: false

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
reactant: MODEL1310110031#
fast: false

metaM leuktrE4 e
constant: false
is: SBO:0000247
boundary condition: false
name: leukotriene E4(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57462
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaM 3ddecdicoa m
is: C05280
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB03952
boundary condition: false
name: 3,6-dodecadienoylcoa

metaR F6Tg
product: MODEL1310110031#
name: glycoprotein 6-alpha-L-fucosyltransferase
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.68
kinetic law: MODEL1310110031#
fast: false
reversible: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR DOLPMT4 Uer
reactant: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

metaM glu L e
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:29985
name: L-glutamate(1-)
is: HMDB00148
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN

metaR PPDOx
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
reversible: false
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
type: Reaction

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110031#_70698869_5d5b_4369_bdb4_ac2f310905a0
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:9551
name: ATP5J2
is: F8W7V3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_05557424_9880_4030_a4e6_1ef5a93b8497
initial amount: NaN
boundary condition: true
constant: false
name: ATP5H
is: A0PJH2
type: Species
is: SBO:0000252
is encoded by: hsa:10476
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ab31254d_8dd5_4940_993d_9aaf2dbaa12c
is encoded by: hsa:3795
boundary condition: true
initial concentration: NaN
is: P50053
is: SBO:0000252
type: Species
name: KHK
initial amount: NaN
constant: false
has only substance units: false

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110031#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false

metaR FUT14g
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69
modifier: MODEL1310110031#

metaM s2l2fn2m2masn e
initial concentration: 1.0
initial amount: NaN
name: PA6
type: Species
constant: false
boundary condition: false
is: HMDB00244
is: CHEBI:3554
is: SBO:0000247
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: C00255
has only substance units: false

metaM ctp m
initial amount: NaN
is: HMDB00082
boundary condition: false
name: CTP(4-)
constant: false
initial concentration: 1.0
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
type: Species
is: SBO:0000247

metaR PPDOy
fast: false
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false

metaM sph1p c
boundary condition: false
is: SBO:0000247
is: CHEBI:57939
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01383
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaM leuktrE4 c
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57462
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
name: leukotriene E4(1-)
is: HMDB02200

http://identifiers.org/biomodels.db/MODEL1310110031#_1a642125_df81_4328_9abd_5e2fcbbeb63b
is encoded by: hsa:BG035985
boundary condition: true
name: _BG035985_1_c
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR COAtm
name: CoA transporter
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
modifier: MODEL1310110031#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
type: Reaction

metaR r2129
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#

metaR ABTD
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#
fast: false
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4a39e6a6_c199_4bcd_b261_be17691046e6
boundary condition: true
is: SBO:0000252
is: Q9HAS3
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: SLC28A3
is encoded by: hsa:64078
initial concentration: NaN

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_769f060b_23f1_45a8_bc87_4b36552ccf80
is encoded by: hsa:2530
type: Species
name: FUT8
is: B4DFS7
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaM 4hexdtetcoa x
name: 4,7,10,13-hexadecatetraenoylcoa
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
constant: false

metaM ctp n
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:37563
is: HMDB00082
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
name: CTP(4-)
boundary condition: false

metaM btcoa m
initial concentration: 1.0
is: C00136
is: HMDB01088
type: Species
name: Butanoyl-CoA
constant: false
is: CHEBI:57371
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM glu L c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: L-glutamate(1-)
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
is: HMDB00148
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_cc27a745_7cbb_42fb_b8e6_9431ff74e42a
type: Species
name: B3GALNT1
initial amount: NaN
is: B3KTQ4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:8706

metaR COAtl
fast: false
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
name: CoA transport in lysosome via diffusion
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true

metaR GDPtg
name: GDP intracellular transport
reactant: MODEL1310110031#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_45de7846_e5ed_4978_92f1_3ccf63f05095
constant: false
is: SBO:0000252
has only substance units: false
is: P14618
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2
type: Species
boundary condition: true
initial amount: NaN

metaM hdca e
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1
is: HMDB00220
is: CHEBI:0
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00249
name: Hexadecanoate (n-C16:0)
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_15d46e6b_60ac_4fdf_9ceb_aae4ea824fe0
has part: P10619
has only substance units: false
is: SBO:0000297
is encoded by: hsa:2588
has part: Q99519
name: GALNS:GLB1:NEU1:CTSA
is encoded by: hsa:2720
constant: false
has part: P34059
type: Species
boundary condition: true
is encoded by: hsa:5476
is encoded by: hsa:4758
has part: P16278
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_772ea113_e572_4d1e_8ae0_cc92d02d71dd
type: Species
initial amount: NaN
is encoded by: hsa:248
boundary condition: true
initial concentration: NaN
is: P09923
constant: false
has only substance units: false
is: SBO:0000252
name: ALPI

http://identifiers.org/biomodels.db/MODEL1310110031#_e0b70e49_de47_4fc2_873f_4cb674075573
has only substance units: false
is encoded by: hsa:26289
type: Species
name: AK5
boundary condition: true
initial amount: NaN
constant: false
is: Q9Y6K8
initial concentration: NaN
is: SBO:0000252

metaR ARAB Lt
type: Reaction
kinetic law: MODEL1310110031#
name: L-arabinoase extracellular transport
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
product: MODEL1310110031#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM sph1p e
type: Species
is: HMDB01383
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0
is: CHEBI:57939
boundary condition: false
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

http://identifiers.org/biomodels.db/MODEL1310110031#_bda909db_f155_4866_a1e0_9531910d128a
is encoded by: hsa:18
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ABAT
is: P80404

metaR NACHEX26ly
type: Reaction
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR FACOAL150
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#

metaR COAtg
fast: false
kinetic law: MODEL1310110031#
name: CoA transport in Golgi via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true

metaM dc2coa m
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:61406
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial concentration: 1.0
has only substance units: false
constant: false
name: trans-Dec-2-enoyl-CoA

metaM aicar e
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C04677
has only substance units: false
is: CHEBI:58475
is: SBO:0000247
constant: false

metaR r2127
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CERT1gt
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304
reversible: true
fast: false
type: Reaction
name: ceramide transport protein
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110031#

metaM pnto R c
initial concentration: 1.0
boundary condition: false
name: (R)-Pantothenate
is: CHEBI:7916
constant: false
type: Species
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_a0c4cdd4_cb58_4399_bf4b_8c9340be16a5
type: Species
initial amount: NaN
initial concentration: NaN
is: P49902
constant: false
has only substance units: false
name: NT5C2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:22978

metaR DSAT
product: MODEL1310110031#
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_45a8b921_dce5_42ef_a926_bcc93d0f508d
initial concentration: NaN
is encoded by: hsa:8818
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: DPM2

metaR r2128
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: true

metaM hdca c
constant: false
is: HMDB00220
is: CHEBI:7896
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
name: palmitate
initial amount: NaN
has only substance units: false

metaR r0245
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
product: MODEL1310110031#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

metaR GLCNACPT L
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.8.15

metaR AG13T2g
is described by: ECO:0000000
reactant: MODEL1310110031#
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#

metaM idp c
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: CHEBI:58280
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1f98b42e_d1c4_44dd_9d7a_f5e5cda009c9
boundary condition: true
type: Species
name: _100287639_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:100287639
is: SBO:0000252

metaR RE1525M
is described by: ECO:0000000
modifier: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is: SBO:0000176
name: RE1525
reversible: true
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_52a1111f_b3f7_4e74_acd3_9f39c837df63
is: SBO:0000252
name: NME1
constant: false
boundary condition: true
is: P15531
initial amount: NaN
is encoded by: hsa:4830
has only substance units: false
type: Species
initial concentration: NaN

metaM crn r
name: (R)-carnitine
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: HMDB00062
initial concentration: 1.0
is: SBO:0000247

metaM aicar c
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
has only substance units: false
is: C04677
initial amount: NaN
is: CHEBI:58475
is: SBO:0000247
constant: false

metaM cytd c
initial concentration: 1.0
is: CHEBI:17562
is: SBO:0000247
is: HMDB00089
type: Species
boundary condition: false
name: Cytidine
is: C00475
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

http://identifiers.org/biomodels.db/MODEL1310110031#_771e41d9_f8c0_42bf_a6fa_31cfa3b17603
is encoded by: hsa:AW277253
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: _AW277253_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_7440989b_2b91_4f76_be2d_cc5dbc8fc1ef
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2954
initial amount: NaN
boundary condition: true
constant: false
name: GSTZ1
has only substance units: false
type: Species

metaR SERDGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
name: D-Serine/Glycine reversible exchange
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000304
reversible: true
fast: false

metaR OCTDECCPT2
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR VITD3t2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
product: MODEL1310110031#
is: SBO:0000185
fast: false
name: Vitamin D3 uptake
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR r2125
fast: false
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true

metaR r0242
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
reversible: true
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_df7b4942_f0fc_41e7_a950_a1442aabbcd7
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: _AL038231_1_c
is encoded by: hsa:AL038231

http://identifiers.org/biomodels.db/MODEL1310110031#_2749041c_2819_493e_82b8_6134206d4dc7
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57379
type: Species
name: AICDA
is: Q546Y9

metaR C4x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r0355
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110031#

metaR r1621
is: SBO:0000185
modifier: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_015cde75_3311_4379_b881_9ffd94a8221c
is: SBO:0000252
initial amount: NaN
name: PDHX
is: O00330
is encoded by: hsa:8050
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR B3GNT12g
product: MODEL1310110031#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110031#

metaM dhcholestanate r
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16577
is: SBO:0000247
is: HMDB00359
initial amount: NaN
has only substance units: false
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaR OCTDECCPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR RE2659R
reversible: true
product: MODEL1310110031#
is: SBO:0000176
name: RE2659
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e1185106_0832_4939_881c_64d746405331
constant: false
is encoded by: hsa:3421
is: E9PDD5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: IDH3G

http://identifiers.org/biomodels.db/MODEL1310110031#_3d258724_58c1_4ae5_a139_ae97664b0ebc
name: ACP2
type: Species
initial amount: NaN
is encoded by: hsa:53
is: SBO:0000252
has only substance units: false
is: E9PCI1
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_8a67dcf0_13ca_4b36_899d_42ecd5834c53
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:5244
has only substance units: false
boundary condition: true
initial amount: NaN
name: ABCB4
initial concentration: NaN

metaR GluForTx
reversible: false
is version of: http://identifiers.org/ec-code/2.1.2.5
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
name: Glutamate formimidoyltransferase
fast: false
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR r2126
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

metaR DM atp c
fast: false
reversible: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110031#
name: DM_atp(c)
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_052c10bf_ab26_41ed_9b98_6df6dcb2d9e8
is: Q9UBM7
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: DHCR7
is encoded by: hsa:1717
boundary condition: true

metaM CE5586 c
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: CHEBI:58732
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
initial amount: NaN
boundary condition: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r1620
kinetic law: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR FE3MTP1
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
reversible: false
name: transport of ferrous iron into blood
is: SBO:0000185
kinetic law: MODEL1310110031#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#

metaR PI45P5Pn
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
type: Reaction
fast: false
reversible: false
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000

metaM 3hddcoa c
has only substance units: false
boundary condition: false
is: HMDB00623
initial concentration: 1.0
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR DAG HSter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
type: Reaction
is described by: ECO:0000000
name: diacylglycerol ER export
product: MODEL1310110031#

metaR GLCAASE9ly
fast: false
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110031#

metaM ei11ecoa x
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
has only substance units: false
type: Species
name: 11-eicosenoylcoa
boundary condition: false

metaM idp e
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: IDP(3-)
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_fe586ffe_9e43_4141_bd45_0134c5735cc8
type: Species
constant: false
name: PANK2
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4839f33e_54c4_4e55_acd9_36578134d605
boundary condition: true
initial amount: NaN
is: P43353
is: SBO:0000252
is encoded by: hsa:221
has only substance units: false
initial concentration: NaN
name: ALDH3B1
type: Species
constant: false

metaR FAOXC14C12m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR LEUTAm
kinetic law: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
name: leucine transaminase, mitochondrial

metaR r1604
product: MODEL1310110031#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR HSD3B11
product: MODEL1310110031#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is described by: ECO:0000134
reactant: MODEL1310110031#
fast: false
type: Reaction
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
reversible: false

metaM adrncoa x
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
name: adrenyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
is: C16170
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR MTHFCm
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110031#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110031#

metaR ENGASE3ly
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110031#
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110031#

metaM T antigen g
boundary condition: false
constant: false
is: CHEBI:22783
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: T antigen (core 1)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_573acffc_95d8_40bb_a62d_46cec5d9549a
name: ACOX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
type: Species
is: B4DK61
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_d744d4d1_7d8a_4a0a_9cd1_8ad2c72ccec9
is: SBO:0000252
constant: false
boundary condition: true
name: DCK
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1633
is: P27707
has only substance units: false

metaR FAOXC102C103m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9cf1ebec_19f6_4c72_9618_65defd68cae6
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:192134
name: B3GNT6
initial amount: NaN
type: Species
is: A8K9Q8

metaR r1605
reversible: true
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6c06510d_21f2_43e5_bc12_3f99bb4502c1
type: Species
is: SBO:0000252
is encoded by: hsa:54407
constant: false
has only substance units: false
is: Q96QD8
name: SLC38A2
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_1a66fd1c_8d0b_4459_9e56_fddaa59b09c2
is: Q9Y5P6
is: SBO:0000252
constant: false
is encoded by: hsa:29925
initial amount: NaN
name: GMPPB
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_8dd25f0a_4fe5_40cb_bfb9_e918a6b85e4c
initial concentration: NaN
type: Species
constant: false
has part: Q9H3S5
name: PIGX:PIGM
has only substance units: false
is encoded by: hsa:54965
has part: Q8TBF5
is encoded by: hsa:93183
is: SBO:0000297
boundary condition: true
initial amount: NaN

metaR HACD1m
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)

metaR S2TASE3ly
reversible: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaR OCTDECCACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR FAOXC122x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_095c1556_b10e_4cfc_a8ec_b8d6094976c6
constant: false
has only substance units: false
name: SYNJ2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8871
type: Species
initial amount: NaN
is: O15056
initial concentration: NaN

metaM elaidcrn c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: Elaidic carnitine
type: Species
is: HMDB06464

metaM hs deg8 l
is: CHEBI:16126
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 8
notes: FORMULA: C69H100N4O81S8 CHARGE: -10

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM met L e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-methionine
is: HMDB00696
is: SBO:0000247
is: CHEBI:16643
boundary condition: false
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

http://identifiers.org/biomodels.db/MODEL1310110031#_21b7dd17_5d47_4998_b0dc_0d2b0c491f88
is encoded by: hsa:272
is: B7Z763
constant: false
name: AMPD3
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM CE4790 m
constant: false
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
type: Species

metaR ALDD2x
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176

http://identifiers.org/biomodels.db/MODEL1310110031#_10e251ca_ab0f_4368_8c89_c19af84e7628
boundary condition: true
name: CPT1A
has only substance units: false
is encoded by: hsa:1374
is: SBO:0000252
is: Q8WZ48
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaM cmpacna g
has only substance units: false
is: HMDB01176
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

http://identifiers.org/biomodels.db/MODEL1310110031#_5f042082_0044_460d_9b8b_c4ba8a6b3b7f
has only substance units: false
is encoded by: hsa:55350
boundary condition: true
has part: O95498
initial amount: NaN
type: Species
is encoded by: hsa:8875
initial concentration: NaN
name: VNN3:VNN2:VNN1
constant: false
is: SBO:0000297

metaR EX tetdece1crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_fa558e8a_3e3c_4bf0_9f02_91458279d867
is encoded by: hsa:LOC374569
name: _LOC374569_1_e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR r1603
product: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1d130823_2c5c_4c77_aa02_e553f8bdf33d
initial amount: NaN
type: Species
constant: false
name: ENTPD8
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:377841
is: Q5MY95
initial concentration: NaN

metaM HC02205 e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:28099
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
type: Species
name: prostaglandin-b2

metaM CE4872 m
initial amount: NaN
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
type: Species
constant: false
is: HMDB00127
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
boundary condition: false
is: SBO:0000247

metaR RE1526M
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
reversible: true
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1526
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110031#
is described by: ECO:0000000

metaR CORE4GTg
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110031#
product: MODEL1310110031#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102

metaR r0909
is: SBO:0000185
reversible: true
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

metaM xol7aone m
boundary condition: false
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial amount: NaN
is: CHEBI:17899
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_9899bf99_0b05_4804_8915_3b6db7202106
boundary condition: true
is: Q6UVY6
has only substance units: false
name: MOXD1
is encoded by: hsa:26002
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaM m7masnB g
constant: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
is: C04946
initial amount: NaN

metaR PYNP2r
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
modifier: MODEL1310110031#
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
reactant: MODEL1310110031#
is: SBO:0000176

metaM CE1944 c
is: SBO:0000247
name: 1-pyrrolinium
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
is: CHEBI:36781
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1600
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110031#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM mescon m
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
has only substance units: false
is: HMDB00749
boundary condition: false
name: Mesaconate
initial amount: NaN
is: CHEBI:36986
initial concentration: 1.0

metaR ACOAD1fm
type: Reaction
is: SBO:0000176
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is described by: ECO:0000269
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR C81CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_5478df01_c40c_4217_bb3c_a74b7d150be9
is: P48448
name: ALDH3B2
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:222
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c82c05d2_214e_42e2_b71d_e00dbc1216fd
boundary condition: true
has only substance units: false
is: Q16706
name: MAN2A1
type: Species
constant: false
is encoded by: hsa:4124
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_aff826e7_19d7_43a6_a3f8_b08721a6706a
constant: false
name: HADH
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q16836
has only substance units: false
type: Species
is encoded by: hsa:3033
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_f860b75d_9ace_41ac_b2d8_f5a9079b9f9c
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q11203
is: SBO:0000252
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN

metaR PSSA2 hs
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
reversible: true
reactant: MODEL1310110031#
is: SBO:0000176

metaR r0908
product: MODEL1310110031#
type: Reaction
fast: false
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000

metaR UMPK7n
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: UMP kinase (dGTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110031#_20c1cd47_b617_45d9_bc8e_30c98f649a6d
is: SBO:0000252
is encoded by: hsa:4121
has only substance units: false
initial amount: NaN
name: MAN1A1
is: P33908
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM s2l2n2m2m l
is: CHEBI:50570
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C84H136N6O62 CHARGE: -2
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB06529
name: de-Fuc form of PA6 (w/o peptide linkage)

metaM mhista c
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00898
is: CHEBI:58600
constant: false
name: N(tele)-methylhistaminium
is: SBO:0000247
initial amount: NaN

metaR DNDPt36m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000269
name: dGDP transport via dCDP antiport
type: Reaction
fast: false
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_2eafb11e_1043_4f07_9e68_be106c7d43d2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:113452
has only substance units: false
name: TMEM54
type: Species
is: Q969K7
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_24222f3c_d314_4b17_9527_dea7fc4b2ccf
boundary condition: true
is: SBO:0000252
name: NME2
type: Species
constant: false
is encoded by: hsa:4831
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P22392

metaR S6TASE2ly
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_0606e2dc_ad26_4660_9555_8bffe0e9f8c5
is encoded by: hsa:8876
is: SBO:0000297
has only substance units: false
has part: O95497
initial amount: NaN
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875
initial concentration: NaN
has part: A8K7W0
type: Species
boundary condition: true
constant: false
is encoded by: hsa:55350

metaM 4aphdob c
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM CE5118 m
initial concentration: 1.0
type: Species
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
constant: false
boundary condition: false

metaR r0661
is: SBO:0000176
fast: false
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM HC01401 x
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27668
initial amount: NaN
type: Species
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
has only substance units: false

metaM HC01434 c
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:58931
constant: false
boundary condition: false
name: oxalatosuccinate(3-)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_8b43d4b1_8954_43cb_9034_15b77fa2a3c3
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA532636
is: SBO:0000252
name: _AA532636_1_m
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaM 7dhf e
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB06559
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
name: heptaglutamyl folate (DHF)
initial amount: NaN

metaR r0660
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176

metaR ITPtn
reversible: true
reactant: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000185
name: ITP nuclear transport
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
product: MODEL1310110031#

metaM g2m8mpdol L r
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:59093
is: SBO:0000247
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_c967085a_ee8a_4664_801d_f263060b7c4c
type: Species
boundary condition: true
is: SBO:0000252
name: AMY2A
initial amount: NaN
constant: false
is: P04746
is encoded by: hsa:279
initial concentration: NaN
has only substance units: false

metaM ser D c
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16523
boundary condition: false
name: D-serine
is: SBO:0000247
is: HMDB03406
type: Species

metaR PYDXtr
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Pyridoxal transport
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9b7cc399_d1a8_4a88_b974_24792518013e
type: Species
name: FUT8
initial concentration: NaN
is: Q9BYC5
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2530
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_5b930013_2c7a_42a7_b4b7_90770c8bb85d
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q6ZWP6
is encoded by: hsa:27034
name: ACAD8
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaM cmpacna c
initial amount: NaN
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
is: HMDB01176

metaM crn x
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
is: CHEBI:16347
name: L-Carnitine
is: HMDB00062
is: SBO:0000247
initial amount: NaN
constant: false
is: C00318
boundary condition: false
initial concentration: 1.0
type: Species

metaM HC00319 c
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: Malonate
constant: false
is: CHEBI:30794
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0

metaM pmtcoa c
type: Species
is: C00154
is: CHEBI:3454
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false

metaR 3MOX4HOXPGALDOX NADP
reactant: MODEL1310110031#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110031#
product: MODEL1310110031#

metaR r1050
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Vesicular transport

metaR CHOLATEt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: true
modifier: MODEL1310110031#
fast: false
name: cholate transport via bicarbonate countertransport
product: MODEL1310110031#
is: SBO:0000185

metaR DALAt2r
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
fast: false
name: D-alanine transport via proton symport
reversible: true
type: Reaction
modifier: MODEL1310110031#

metaR LNLNCGCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reversible: false
product: MODEL1310110031#
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
modifier: MODEL1310110031#

metaR CATm
is: SBO:0000176
reactant: MODEL1310110031#
name: catalase
type: Reaction
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
modifier: MODEL1310110031#
is described by: ECO:0000269
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.11.1.6
reversible: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_723cd096_40d3_4903_a55d_60555d719928
is encoded by: hsa:55577
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: Q9UJ70
initial concentration: NaN
has only substance units: false
name: NAGK
is: SBO:0000252

metaM c4dc x
notes: FORMULA: C11H18NO6 CHARGE: -1
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
name: succinyl carnitine
is: C02862
type: Species
initial amount: NaN
is: HMDB02013
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR N3Tg
type: Reaction
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
fast: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000

metaR RE1810M
reversible: true
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
name: RE1810
is described by: ECO:0000000
type: Reaction

metaM hdcea c
constant: false
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Hexadecenoate (n-C16:1)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galacglcgal14acglcgalgluside_hs_g
has only substance units: false
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:26174
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: i-antigen
is: SBO:0000247

metaR r1758
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110031#

metaM ala D c
type: Species
boundary condition: false
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
constant: false
name: D-alanine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15570

metaR r1051
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110031#_4a0aa71b_3627_4acd_8885_3dc59378c025
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:517
name: ATP5G2
is: Q06055
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_31a09306_10f9_44b7_98aa_0a5dd769f17f
is: SBO:0000252
is: P22234
name: PAICS
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10606
initial concentration: NaN

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
has only substance units: false
is: CHEBI:28259
constant: false
is: HMDB01052

metaM thexddcoa m
initial concentration: 1.0
is: HMDB02288
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: trans7,10-hexadecadienoylcoa
initial amount: NaN

metaR UGLCNACtg
is described by: ECO:0000269
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reversible: true
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_cce5b5a6_2d58_4674_9739_7ba145a7bab7
is: A5PKZ1
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GALNT5
type: Species
initial amount: NaN
is encoded by: hsa:11227
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_648a359b_082e_41ab_aceb_0ce30119fe37
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: ACO2
initial concentration: NaN
is: Q99798
initial amount: NaN
has only substance units: false
is encoded by: hsa:50

metaR AG13T16g
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
modifier: MODEL1310110031#

metaM air c
constant: false
type: Species
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
initial amount: NaN
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: HMDB01235
boundary condition: false
is: C03373
is: SBO:0000247
has only substance units: false
is: CHEBI:58592
initial concentration: 1.0

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_02bf52f2_fcc8_4792_985c_0a39f36133c0
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:622
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q02338
name: BDH1
constant: false

metaM CE4872 c
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
type: Species
constant: false
has only substance units: false
is: HMDB00127
boundary condition: false

metaM acac x
name: acetoacetate
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM adrncoa m
initial concentration: 1.0
name: adrenyl coenzyme A
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480

http://identifiers.org/biomodels.db/MODEL1310110031#_8dcdf785_3882_4f3f_aebc_d51fa8faf546
boundary condition: true
name: _AI291895_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI291895
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_29f9b06f_3577_4b71_abea_be9a56bf4c46
is encoded by: hsa:2182
boundary condition: true
type: Species
name: ACSL4
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O60488

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
is: CHEBI:17899
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_32468b45_e287_48c1_a938_cff7cd57428b
has only substance units: false
is encoded by: hsa:6546
initial amount: NaN
name: SLC8A1
boundary condition: true
type: Species
is: F6VPY9
constant: false
initial concentration: NaN
is: SBO:0000252

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR H2O2tn
name: hydrogen peroxide nuclear transport
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110031#
is: SBO:0000185

metaM Tn antigen l
constant: false
name: Tn antigen
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR HOCTDECCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM ala D e
has only substance units: false
initial amount: NaN
is: HMDB01310
type: Species
name: D-alanine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15570
boundary condition: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaR FAOXC183C163Gm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_b4e35df6_b90f_4019_9782_373eba414d35
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: SLC26A8
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:116369

metaM hdcea e
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB03229
name: Hexadecenoate (n-C16:1)
type: Species

metaM m7masnB r
notes: FORMULA: C64H107N2O50X CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
is: C04946
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)

metaR CYTK11n
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110031#
name: cytidylate kinase (dCMP,dGTP),nuclear
product: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110031#_a33fddf0_419d_4c91_9b4b_4741c23d94b2
is: SBO:0000252
initial concentration: NaN
name: PDE9A
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5152
constant: false

metaM 3deccrn e
is: SBO:0000247
name: 3-hydroxydecanoylcarnitine
type: Species
boundary condition: false
notes: FORMULA: C17H33NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB02250
initial amount: NaN
constant: false
has only substance units: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9a6fc34a_61a6_436e_b5d4_b7e35fbb4998
has only substance units: false
name: SLC25A1
is encoded by: hsa:6576
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: D9HTE9
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_be287f56_fbf8_4474_a68a_505bc6e64064
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4594
is: P22033
name: MUT
type: Species
boundary condition: true

metaM HC01434 m
has only substance units: false
is: SBO:0000247
name: oxalatosuccinate(3-)
type: Species
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM hexdicoa c
initial amount: NaN
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB02014
boundary condition: false
name: hexadecanedioylcoa
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: Tn antigen
initial concentration: 1.0
has only substance units: false
is: C04383

http://identifiers.org/biomodels.db/MODEL1310110031#_ce984ae2_3ca3_44be_8e55_9d8e71ffeb45
is: Q3I5F7
type: Species
name: ACOT6
is encoded by: hsa:641372
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaR FAOXC122m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR XYLtly
product: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
name: Xylose efflux from lysosome
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD

metaM met L c
constant: false
is: HMDB00696
name: L-methionine
is: CHEBI:16643
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r1464
is: SBO:0000185
product: MODEL1310110031#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaR r0502
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176

metaR r1608
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaR DOLPGT2 Ler
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
is described by: ECO:0000000
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.265
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_c4f2409f_2399_4064_9d93_afc78003a7bc
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4702
name: NDUFA8
initial amount: NaN
is: B1AM93

metaR r1167
fast: false
name: EC:2.3.1.26
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_179e0946_826e_4107_a484_2c4b99aba419
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:522
has only substance units: false
name: ATP5J
is: SBO:0000252
boundary condition: true

metaR FAOXC1811602m
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
type: Reaction
product: MODEL1310110031#
name: Beta oxidation fatty acid
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_cab8a787_2d04_4811_b613_6285663f50f1
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: UPP1
is: SBO:0000252
is encoded by: hsa:7378
has only substance units: false

metaM 3thexddcoa m
name: 3-hydroxy trans7,10-hexadecadienoylcoa
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
has only substance units: false
is: HMDB02014
boundary condition: false
constant: false
initial concentration: 1.0

metaR FAOXC161802m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
name: Beta oxidation fatty acid
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
type: Reaction

metaR NRPPHRt4 2 r
is: SBO:0000185
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110031#
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR ALDD2y
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reversible: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_cd6d3825_4622_4b8a_a3fb_00c0dbcfdac1
is: P28330
initial concentration: NaN
constant: false
is encoded by: hsa:33
is: SBO:0000252
name: ACADL
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_acd567aa_fb05_466d_967a_8dcd4d0504d3
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: PCBD1
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5092
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110031#_9ea642e7_188c_4e36_b544_87036157895e
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: FPGT
is: SBO:0000252
is: O14772
is encoded by: hsa:8790
initial concentration: NaN

metaM man r
has only substance units: false
initial amount: NaN
is: HMDB00169
boundary condition: false
name: D-mannose
constant: false
is: CHEBI:16024
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
initial concentration: 1.0

metaR HDDACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r1609
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 3m4hpga c
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7909
boundary condition: false
initial concentration: 1.0
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: C05583
has only substance units: false
type: Species
is: HMDB04061
is: SBO:0000247

metaM hs deg23 l
is: CHEBI:21338
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
is: HMDB02704

metaR TIGCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR 34DHOXPEGOX
modifier: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase

metaM 2octdectecoa x
initial amount: NaN
type: Species
name: 2,6,9,12-octadecatetraenoylcoa
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
has only substance units: false

metaR CYSGLTH
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: Glutathione:cystine oxidoreductase
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR DURIPP
is described by: ECO:0000269
product: MODEL1310110031#
is: SBO:0000176
name: deoxyuridine phosphorylase
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
fast: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true

metaM dhlpro m
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
is: CHEBI:16194
name: Dihydrolipolprotein
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r1466
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: EC:2.3.1.86

http://identifiers.org/biomodels.db/MODEL1310110031#_9a82e6c0_968b_4033_ac22_7bc398888730
is encoded by: hsa:6532
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: SLC6A4
is: SBO:0000252
is: P31645
has only substance units: false

metaM clpn hs c
notes: FORMULA: CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: HMDB02704
constant: false
is: SBO:0000247
initial amount: NaN
name: clpn_hs[c]
boundary condition: false
type: Species
is: CHEBI:21338

http://identifiers.org/biomodels.db/MODEL1310110031#_a87a3887_edd9_44f3_b1f4_8e8b730bddbb
name: MTHFD2L
constant: false
is encoded by: hsa:441024
initial amount: NaN
initial concentration: NaN
is: Q9H903
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR r0504
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
product: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110031#
type: Reaction

metaR GASNASE3ly
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
name: glycosylasparaginase, lysosomal
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26

metaR r1606
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110031#_0a9c96d3_12a7_4b05_aa11_468c9066159e
initial concentration: NaN
is: Q6PCB7
name: SLC27A1
is encoded by: hsa:376497
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR HSAT4ly
fast: false
reactant: MODEL1310110031#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaM m8masn r
has only substance units: false
is: C05876
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110031#_dcb0245e_5c81_46e0_9715_43c09934fccd
is encoded by: hsa:131669
is: Q68CJ7
name: UROC1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM vacccoa m
is: SBO:0000247
is: HMDB06521
type: Species
name: vaccenyl coenzyme A
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
boundary condition: false

metaR PRGNLONESULT
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
name: steroid sulfotransferase
reactant: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.2
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.14

http://identifiers.org/biomodels.db/MODEL1310110031#_740bc90d_4258_4cbe_b3dc_3061d28a1ed4
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10861
constant: false
initial concentration: NaN
type: Species
name: SLC26A1
is: Q9H2B4
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_35c8c5d2_18c6_4ead_93be_90fd12dd1322
constant: false
is encoded by: hsa:3099
initial amount: NaN
boundary condition: true
is: P52789
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: HK2

metaR r1467
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
name: Postulated transport reaction
fast: false
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_dcb1e20e_de5f_4c3a_b49f_2e5dc95e426c
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:7389
is: P06132
name: UROD
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaM glu5p m
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58274
constant: false
name: L-Glutamate 5-phosphate
initial concentration: 1.0
type: Species
is: HMDB01228
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287

metaR r1607
reversible: true
kinetic law: MODEL1310110031#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR EX tetdec2crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaR RE3074X
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
name: RE3074
modifier: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaR FAOXC226m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR r0381
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
product: MODEL1310110031#
reversible: true
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_da08e20e_c90c_4bfa_a0f9_386f22a18a9c
has only substance units: false
name: RRM2
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6241
is: P31350
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_59a0775c_128b_4038_b458_42dc812470be
boundary condition: true
is encoded by: hsa:5145
type: Species
is: SBO:0000252
initial concentration: NaN
name: PDE6A
has only substance units: false
initial amount: NaN
constant: false
is: P16499

http://identifiers.org/biomodels.db/MODEL1310110031#_dc7ce536_df93_43a0_a157_02d4b8867191
boundary condition: true
name: NSF
is encoded by: hsa:4905
initial concentration: NaN
is: P46459
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM leuktrC4 e
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
is: CHEBI:57973
type: Species
constant: false
name: leukotriene C4(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5cf8871a_b57a_4b9f_b8be_c9c7ff00e28d
is: Q9Y4C5
has only substance units: false
name: CHST2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9435
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_3dfda8da_697a_48dc_bb46_77313ddb8d50
is encoded by: hsa:2618
initial amount: NaN
is: Q59HH3
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: GART
initial concentration: NaN

metaR C10OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM dcamp c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
type: Species
name: N6-(1,2-Dicarboxyethyl)-AMP
is: CHEBI:57567
is: HMDB00536
constant: false

metaM 3pg m
type: Species
constant: false
is: HMDB00807
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false
is: CHEBI:58272
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1e901556_e06c_4c83_8936_e2e0366cf9b8
name: ACSL4
type: Species
has only substance units: false
is encoded by: hsa:2182
is: Q5JWV8
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR F1PGT
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110031#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
name: fucose-1-phosphate guanylyltransferase
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_571008e1_00b2_4524_9cd5_9945046fe55f
has only substance units: false
is encoded by: hsa:64902
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: AGXT2
initial amount: NaN
is: Q9BYV1

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_431e34f4_c7d7_421a_9414_91cda8a5a863
type: Species
is encoded by: hsa:1593
boundary condition: true
name: CYP27A1
initial amount: NaN
constant: false
is: Q02318
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ksii core4 pre1 g
constant: false
type: Species
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
boundary condition: false
has only substance units: false

metaM 4pyrdx e
initial amount: NaN
is: SBO:0000247
name: 4-pyridoxate
is: HMDB00017
is: CHEBI:30959
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
boundary condition: false
constant: false

metaR LEUtec
product: MODEL1310110031#
name: L-leucine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction

metaR r0384
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000

metaR SUBERICACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247
name: D-mannose
type: Species
constant: false
is: HMDB00169
is: CHEBI:16024
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM pan4p e
is: SBO:0000247
is: CHEBI:47942
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2
name: Pantetheine 4'-phosphate
is: HMDB01416
initial concentration: 1.0
boundary condition: false

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM ocdca e
has only substance units: false
is: SBO:0000247
constant: false
is: C01530
type: Species
is: HMDB00827
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)

metaM ksi pre17 g
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
type: Species
is: CHEBI:28067
constant: false

metaR B3GNT51g
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
modifier: MODEL1310110031#
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110031#
reversible: false

metaM acac m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
is: HMDB00060
is: CHEBI:13705
name: acetoacetate
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f56a2310_e6ee_4af3_9604_7ccadb6ac3be
type: Species
is encoded by: hsa:4722
name: NDUFS3
boundary condition: true
constant: false
is: SBO:0000252
is: O75489
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_c1194374_f3e1_4a4f_a443_544553a39409
has only substance units: false
is: SBO:0000252
constant: false
name: _AI990637_1_x
is encoded by: hsa:AI990637
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR PGDI
reactant: MODEL1310110031#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110031#
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.3.99.2

http://identifiers.org/biomodels.db/MODEL1310110031#_3a16fa2d_bbca_4395_b558_126eb816ac0e
boundary condition: true
has only substance units: false
is: SBO:0000297
is encoded by: hsa:5295
has part: E7EX19
initial amount: NaN
initial concentration: NaN
constant: false
name: PIK3CD:PIK3R1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_2b55f739_5f0e_4000_88c5_a59f145d89c3
initial concentration: NaN
constant: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:515
type: Species

metaM ksi deg30 l
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00143
constant: false
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
name: keratan sulfate I, degradation product 30

metaR N2M2NMASNtly
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
fast: false
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
is: SBO:0000185

metaM leuktrC4 c
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
is: CHEBI:57973
name: leukotriene C4(2-)
is: HMDB01198
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaM 34hpp e
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00707
is: CHEBI:36242

metaR FAOXC163C164Gm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR ACOAO7p
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
fast: false
type: Reaction
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is described by: ECO:0000269
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_84d76a5b_56b4_47ec_8a23_2cfe66f1f0e4
boundary condition: true
has only substance units: false
is encoded by: hsa:2686
is: A0PJJ9
constant: false
name: GGT7
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR BDMT L
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.142
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false

metaR ASNGLNNaEx
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_88a7cf08_329d_46eb_8ffa_3000a3315bd2
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: IDH1
is encoded by: hsa:3417
is: SBO:0000252
is: O75874
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_f86f07e7_80ea_4178_8cde_6f7d44f14c65
name: _NM_001929_1_c
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:NM 001929
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e13308b6_ffc0_4dac_b84b_35e30e0bb2fb
has only substance units: false
type: Species
name: ELOVL5
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:60481
initial concentration: NaN
is: F6SH78
boundary condition: true

metaR HIVCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR DIGALSIDEtl
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: digalside hs intracellular transport

metaR S6T5g
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110031#

metaR CYTK3n
product: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 4pyrdx c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00017
name: 4-pyridoxate
is: CHEBI:30959
constant: false
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_a2488351_23f5_4ce6_a530_5adff2aa7fb7
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: _AA419122_1_c
has only substance units: false
is encoded by: hsa:AA419122
constant: false
is: SBO:0000252

metaR C4DCCACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR SBT Dtde
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
type: Reaction
fast: false
name: D-sorbitol transport, extracellular
is described by: ECO:0000134
kinetic law: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_e81dae96_6c3e_4a13_a72a_c4e1ce8b2122
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
has part: B4DER4
boundary condition: true
type: Species
constant: false
initial amount: NaN
has part: B3KT19
has only substance units: false
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5291

metaM ocdca c
is: SBO:0000247
type: Species
constant: false
is: HMDB00827
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
name: stearate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:25629
boundary condition: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaM pan4p c
is: HMDB01416
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: CHEBI:47942
type: Species
constant: false
initial amount: NaN
name: Pantetheine 4'-phosphate
is: C01134
initial concentration: 1.0
boundary condition: false

metaR TXASr
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000134
product: MODEL1310110031#
name: Thromboxane-A synthase
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.3.99.5
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bbee8dca_2e0f_4a3a_8755_51d83244e0c9
type: Species
constant: false
is encoded by: hsa:125206
boundary condition: true
name: SLC5A10
initial amount: NaN
is: A0PJK1
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_ad5f2e6e_c598_4ffb_9869_5f6d72cbe79d
initial amount: NaN
name: PLCD3
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: Q8N3E9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:113026

metaR EX c81crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaM 34hpp c
type: Species
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
boundary condition: false
is: CHEBI:36242
is: HMDB00707
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

metaR r0082
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.2
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
is: SBO:0000176

metaM galgbside hs g
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
constant: false
is: CHEBI:18259
name: galactosylgloboside
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaM 3deccrn c
initial concentration: 1.0
initial amount: NaN
is: HMDB00651
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: 3-hydroxydecanoylcarnitine
notes: FORMULA: C17H33NO5 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_0d877b41_fbdc_49fb_be83_796064369075
boundary condition: true
type: Species
name: CHKB
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1120
initial amount: NaN
initial concentration: NaN
is: A0PJM6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1ef6ddce_2b43_4f8f_bdd7_a38a3526ae1c
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:D87002
name: _D87002_1_e

http://identifiers.org/biomodels.db/MODEL1310110031#_c1b468fb_9ae7_4c13_b0a3_69d6be1a3456
boundary condition: true
name: SLC8A3
is encoded by: hsa:6547
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaR r2391
fast: false
reversible: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_daecbd3b_9a8f_46c8_bcca_4abe38b926af
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6472
name: SHMT2
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: B4DJQ3

metaR MECOAS1m
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
reactant: MODEL1310110031#

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f0714663_ba63_4519_83d2_55c8297d360c
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: Q8NFF2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
boundary condition: true
name: SLC24A4

metaM adrncoa c
initial concentration: 1.0
boundary condition: false
is: C16170
constant: false
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
name: adrenyl coenzyme A

metaR H2O2tp
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110031#
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
fast: false
reversible: true
is described by: ECO:0000000
name: blood group intracellular transport
product: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110031#
type: Reaction

metaR r0083
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
modifier: MODEL1310110031#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_21ef9b4f_1001_4826_b5a2_6fc083684fbb
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5831
is: A6NFM2
constant: false
name: PYCR1

http://identifiers.org/biomodels.db/MODEL1310110031#_dd7cd216_f379_4460_a905_a0cc44c90acc
name: GALNT2
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2590
type: Species
is: SBO:0000252
is: Q10471
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_f0a394c8_b6da_4975_b010_b08db9bcff6a
type: Species
is encoded by: hsa:51227
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
has part: Q14442
has part: Q9BRB3
is encoded by: hsa:8818
is: SBO:0000297
constant: false
has part: Q92535
is encoded by: hsa:5277
has part: O94777
boundary condition: true
is encoded by: hsa:5283
has only substance units: false
is encoded by: hsa:5279
has part: B3KUV7
initial concentration: NaN

metaR r0388
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#

metaM retfa c
is: SBO:0000247
name: fatty acid retinol
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
is: CHEBI:50211
is: HMDB00305
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM oagd3 hs g
is: SBO:0000247
initial amount: NaN
is: CHEBI:58367
boundary condition: false
constant: false
is: C00029
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species
has only substance units: false
name: 9-O-Acetylated GD3
initial concentration: 1.0
is: HMDB00286

http://identifiers.org/biomodels.db/MODEL1310110031#_31f8c73f_3ecf_45cd_92e3_3afd41cdee5a
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7359
boundary condition: true
initial amount: NaN
name: _7359_1_c
is: SBO:0000252
type: Species

metaR BUTt2r
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
name: Butyrate transport via proton symport, reversible
is described by: ECO:0000269
fast: false
reversible: true

metaR DPHMBDCm
is: SBO:0000176
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
type: Reaction

metaR r0389
fast: false
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_34e8c145_b89f_4327_8066_d49f3f6e361f
is encoded by: hsa:8310
has part: O15254
boundary condition: true
has only substance units: false
has part: Q9NY65
type: Species
initial amount: NaN
name: EHHADH:ACAA1:HSD17B4:ACOX3
is encoded by: hsa:1962
initial concentration: NaN
constant: false
is: SBO:0000297

metaR r0236
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110031#
fast: false

metaR AGTim
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110031#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
kinetic law: MODEL1310110031#
reversible: false
product: MODEL1310110031#
is: SBO:0000176

metaR RE0690E
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0690
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110031#
type: Reaction

metaR CHOLt4
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110031#
is described by: ECO:0000269
name: choline, sodium cotransport
reversible: true
type: Reaction
is: SBO:0000185

metaM ha deg1 l
has only substance units: false
type: Species
initial concentration: 1.0
name: hyaluronan degradation product 1
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110031#_1b5ee59d_acb7_444d_bcad_5000ac587ade
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11136
constant: false
has part: Q07837
boundary condition: true
type: Species
is: SBO:0000297
has part: P82251
name: SLC7A9:SLC3A1
has only substance units: false
is encoded by: hsa:6519

metaR CRNtim
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
fast: false
type: Reaction
name: L-carnitine transport out of mitochondria via diffusion
modifier: MODEL1310110031#

metaM pail3p hs c
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58088

metaM HC01610 e
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28607
name: CoproporphyrinogenI
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
has only substance units: false

metaR COQ3m
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
fast: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.1.1.114
reversible: false
is: SBO:0000176
type: Reaction
name: methyltransferase COQ3
is described by: ECO:0000269
reactant: MODEL1310110031#

metaM glyc3p c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57597
initial amount: NaN
is: HMDB00126
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_74323899_0807_400a_8771_bb8305505908
is encoded by: hsa:64077
initial amount: NaN
name: LHPP
initial concentration: NaN
type: Species
boundary condition: true
is: Q9H008
constant: false
is: SBO:0000252
has only substance units: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM 3thexddcoa c
is: HMDB02014
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 3-hydroxy trans7,10-hexadecadienoylcoa
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
name: blood group intracellular transport
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
fast: false

metaR NAGAlby
product: MODEL1310110031#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
name: N-acetylgalactosaminidase, beta-

http://identifiers.org/biomodels.db/MODEL1310110031#_428eb9e6_a129_49a1_ac08_c3bb73bbba22
has only substance units: false
constant: false
is: SBO:0000252
name: ACP2
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:53
initial concentration: NaN
is: E9PCI1

metaR IDOAASE2ly
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
fast: false
type: Reaction
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6656ef14_0b56_4a95_ad97_964d3559e113
boundary condition: true
is: Q59FD4
initial amount: NaN
type: Species
is encoded by: hsa:3098
is: SBO:0000252
constant: false
name: HK1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_fe0776c2_ba10_4068_9bce_6a300ad1f794
is: SBO:0000252
name: SLC8A3
is: B3KU59
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6547
type: Species
boundary condition: true
constant: false

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110031#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110031#
reversible: true

metaR FRUt4
is: SBO:0000185
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
is described by: ECO:0000269
name: D-fructose transport via sodium cotransport
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR GPIAT
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is described by: ECO:0000269
name: glucosaminylphosphatidyl inositol acetyltransferase
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
reversible: false
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_49340084_56e0_41e0_afdd_ac49e7481031
constant: false
initial amount: NaN
has only substance units: false
name: SLC5A3
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6526
is: SBO:0000252
is: P53794

metaR r0086
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.1.3

metaR ABO9g
is version of: http://identifiers.org/ec-code/2.4.1.37
modifier: MODEL1310110031#
reversible: false
product: MODEL1310110031#
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
fast: false

metaR NACHEXA16ly
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_68a3f261_abca_4f27_92bc_766e8e8d5393
boundary condition: true
is encoded by: hsa:23007
constant: false
initial amount: NaN
initial concentration: NaN
is: Q4KWH8
name: PLCH1
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_a6c7c695_03e8_4c98_8f50_1abbe6ec8be1
initial concentration: NaN
is: A8K5Z0
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8703
type: Species
initial amount: NaN
name: B4GALT3
has only substance units: false

metaM oagd3 hs c
is: SBO:0000247
name: 9-O-Acetylated GD3
is: HMDB00286
initial concentration: 1.0
has only substance units: false
constant: false
is: C00029
boundary condition: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:58367
type: Species
initial amount: NaN

metaM gdpddman c
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01346
is: CHEBI:57964
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaM xol7aone r
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
type: Species
is: CHEBI:17899
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR CHSTEROLtrc
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
name: transport of cholesterol into the cytosol
is described by: ECO:0000134

metaR GTHDH
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#

metaR ADRNCPT2
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
modifier: MODEL1310110031#
name: carnitine transferase

metaM acac e
initial amount: NaN
has only substance units: false
is: CHEBI:13705
is: HMDB00060
name: acetoacetate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species

metaR PYDXDH
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
is version of: http://identifiers.org/ec-code/1.2.3.1
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
name: pyridoxal dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110031#_cdf291e4_ae8e_476c_839f_7718c5491992
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:9551
type: Species
is encoded by: hsa:517
constant: false
is: SBO:0000297
has only substance units: false
has part: F8W7V3
initial concentration: NaN

metaR ADPACTD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM g1m8mpdol U r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:59093
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM ksii core2 pre4 g
is: CHEBI:58053
notes: FORMULA: C53H86N4O38X CHARGE: -1
constant: false
is: HMDB00175
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00130
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4

metaR IDOURtly
fast: false
reactant: MODEL1310110031#
type: Reaction
name: iduronate transport into lysososme
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
reversible: true
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#

metaR FAOXC121C101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_85c2c11f_0eb8_4ddf_92e2_44e3457090dd
is encoded by: hsa:2588
initial amount: NaN
has only substance units: false
name: GALNS
initial concentration: NaN
type: Species
boundary condition: true
is: P34059
is: SBO:0000252
constant: false

metaR BDMT U
reversible: false
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.142
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM man g
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00169
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
is: CHEBI:16024

metaR DOLPMT2 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: false
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000

metaR r0084
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_db47660a_4033_4558_b909_92f71ee3d0ea
initial concentration: NaN
name: HLCS
is: P50747
is encoded by: hsa:3141
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaM dtdp e
is: HMDB01274
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
type: Species
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247

metaM 34hpp m
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: CHEBI:36242
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB00707

metaR CRNt
fast: false
reversible: true
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
name: L-carnitine reversible transport
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_f45a60d4_326b_477a_9f6e_ce5f3bfb171d
boundary condition: true
is encoded by: hsa:122622
is: SBO:0000252
is: Q8N142
name: ADSSL1
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57795
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101

metaR SMS
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.27
type: Reaction
fast: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
kinetic law: MODEL1310110031#

metaR ACNAMlt
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
name: N-acetylneuraminate transport into lysososme
reversible: true
is described by: ECO:0000269
is: SBO:0000185

metaM oagd3 hs e
is: HMDB02168
is: SBO:0000247
is: CHEBI:18421
name: 9-O-Acetylated GD3
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110031#_19d48b03_7301_4673_b004_5727d124ea75
has only substance units: false
constant: false
name: SYNJ1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O43426
boundary condition: true
type: Species
is encoded by: hsa:8867

metaR G14T16g
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110031#

metaR r0085
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
fast: false
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

metaM CE4792 m
is: CHEBI:57923
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
name: 3-oxo-cis-8-tetradecenoyl-CoA
type: Species
initial concentration: 1.0

metaM HC02205 c
type: Species
is: SBO:0000247
is: CHEBI:28099
boundary condition: false
name: prostaglandin-b2
constant: false
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
initial concentration: 1.0

metaR INSt
is described by: ECO:0000269
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
name: Inosine transport (diffusion)
type: Reaction

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_fd8c143b_ca06_4874_ac42_807c5e20b747
is: O43280
initial concentration: NaN
initial amount: NaN
name: TREH
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:11181
is: SBO:0000252

metaM Asn X Ser Thr r
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:28938
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
is: C01342
initial amount: NaN
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_90427323_c834_417a_8acb_9f4e8c630096
boundary condition: true
is: SBO:0000252
is: P22413
initial amount: NaN
type: Species
name: ENPP1
has only substance units: false
is encoded by: hsa:5167
constant: false
initial concentration: NaN

metaM dtdp c
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01274
is: C00363
has only substance units: false
name: dTDP
type: Species
initial concentration: 1.0

metaR 5MTAte
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 5-S-methyl-5-thioadenosine
is described by: ECO:0000134
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_aed32a4a_fb52_45f4_9cd1_42ce80d75754
name: COX4I1
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1327
is: P13073
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_395050b8_49cb_4990_b71e_b7c4e36c38c2
is: P31350
is: SBO:0000252
is encoded by: hsa:6241
constant: false
initial concentration: NaN
name: RRM2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r0655
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110031#_edd33339_2ba6_4c73_aff6_bea88b5e5f8c
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:205
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: AK4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_a49f0d48_01fa_4cb5_b828_8c12ed7b32b9
is encoded by: hsa:5631
has only substance units: false
is: SBO:0000252
is: P60891
initial concentration: NaN
constant: false
name: PRPS1
initial amount: NaN
type: Species
boundary condition: true

metaR FAOXC225x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR 3MOX4HOXPGALDOX
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110031#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110031#
is described by: ECO:0000304
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM glyc3p m
is: HMDB00126
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
boundary condition: false
initial concentration: 1.0
is: C00093
name: Glycerol 3-phosphate
constant: false
has only substance units: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM 3octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355
name: 3,6,9,12,15-octadecapentenoylcoa
type: Species
is: SBO:0000247

metaM man c
type: Species
is: SBO:0000247
is: C00159
is: CHEBI:16024
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
initial concentration: 1.0
is: HMDB00169
initial amount: NaN
constant: false
boundary condition: false

metaM 3pg c
boundary condition: false
type: Species
is: HMDB00807
constant: false
name: 3-Phospho-D-glycerate
has only substance units: false
is: CHEBI:58272
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3497
initial amount: NaN
is: C00197

metaR ADRNCPT1
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110031#
product: MODEL1310110031#

metaR NDP10ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
name: nucleoside-diphosphatase (IDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: false
type: Reaction

metaR SERGLNexR
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: L-Serine/Glutamine reversible exchange
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110031#_6bcee71f_a043_4c81_ab3b_e30749a3113b
name: AKR1B1
is: P15121
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:231
type: Species

metaM hdcea r
name: palmitoleate
is: CHEBI:32372
constant: false
type: Species
is: HMDB03229
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM hexdicoa r
initial amount: NaN
is: HMDB00672
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
name: hexadecanedioylcoa
has only substance units: false
is: C08260
is: SBO:0000247
type: Species

metaM HC00319 m
name: Malonate
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_18443d9d_356b_4727_bf03_57211aeab4b5
boundary condition: true
name: GUK1
initial amount: NaN
is encoded by: hsa:2987
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q16774
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_9f3fc4a9_5192_46d1_8246_40f3572a4452
has only substance units: false
initial amount: NaN
name: _AI761708_1_m
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI761708
initial concentration: NaN
type: Species

metaM glcur r
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
initial concentration: 1.0
boundary condition: false
is: CHEBI:15748
has only substance units: false
type: Species
name: D-glucuronate
is: SBO:0000247
constant: false

metaM octdececoa m
initial amount: NaN
name: octadecenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR RADH2
kinetic law: MODEL1310110031#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110031#
name: retinal dehydrogenase (NADPH)
reactant: MODEL1310110031#

metaM ametam c
is: CHEBI:57443
type: Species
has only substance units: false
name: S-Adenosylmethioninamine
is: C01137
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00988
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_32db94c9_db75_43db_a5e6_d3a3d94075b2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6820
boundary condition: true
has only substance units: false
constant: false
name: SULT2B1

http://identifiers.org/biomodels.db/MODEL1310110031#_161986ca_55a3_47c4_aed3_3930fd1e9f13
boundary condition: true
is: P26572
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: MGAT1
is encoded by: hsa:4245
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2a3cd04d_ed48_4d47_b4be_b54ea8421a6b
is: SBO:0000252
name: PFAS
initial concentration: NaN
is: Q6P4B4
is encoded by: hsa:5198
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR RE3245C
name: RE3245
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6aeea94e_74d1_41fe_9359_67234a8c9ae9
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84701
name: COX4I2
boundary condition: true
is: Q96KJ9
type: Species

metaR THMMPtm
name: Thiamine monophosphate transport, mitochondrial
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185

metaR P45027A11m
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
fast: false
modifier: MODEL1310110031#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR FAOXC181C161m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR RE0830C
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830

metaR SERALANaEx
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: false

metaM but e
has only substance units: false
is: HMDB00039
name: butyrate
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17968

http://identifiers.org/biomodels.db/MODEL1310110031#_36a969cf_cbe5_497c_ad5f_7ec37669e453
is encoded by: hsa:5148
type: Species
boundary condition: true
constant: false
is: P18545
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDE6G

metaR G13MT L
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.132
product: MODEL1310110031#
reversible: false

metaR C4tmc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

metaR r2535
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true

metaR RTOTALFATPc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR GLNALANaEx
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
reactant: MODEL1310110031#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b202f9b6_bd06_4451_8fd7_24936c18eb50
initial amount: NaN
has only substance units: false
boundary condition: true
name: IDH3B
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3420
initial concentration: NaN

metaR ADPRIBt
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:IT
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.2.2.5
reversible: false
name: ADPribose transport

metaM galside hs g
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaM s2l2n2m2masn l
name: de-Fuc form of PA6
boundary condition: false
is: HMDB00174
constant: false
initial concentration: 1.0
is: CHEBI:18287
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C84H135N6O61X CHARGE: -2
has only substance units: false
type: Species

metaR r0913
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM dtdp m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01274
boundary condition: false
name: dTDP
type: Species
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
is: C00363
has only substance units: false

metaM 6pgl r
type: Species
boundary condition: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: CHEBI:57955
initial amount: NaN
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: HMDB01127
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR ACt2r
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
name: acetate reversible transport via proton symport

metaR SERDGLNexR
product: MODEL1310110031#
reactant: MODEL1310110031#
name: D-Serine/Glutamine reversible exchange
is: SBO:0000185
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR r2534
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reversible: true

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM glc D l
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial concentration: 1.0
is: CHEBI:4167
has only substance units: false
is: HMDB00122
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaM 56dthm c
is: SBO:0000247
boundary condition: false
type: Species
name: 5,6-dihydrothymine
is: HMDB00079
initial amount: NaN
has only substance units: false
is: CHEBI:27468
constant: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_d9baa4a8_3df5_44c6_b1a7_476ba103cf22
initial concentration: NaN
is: SBO:0000252
name: SLC25A26
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:115286
has only substance units: false
is: F8WAB8

http://identifiers.org/biomodels.db/MODEL1310110031#_30438a56_7b4a_4cac_a20d_e84afeda9d67
initial concentration: NaN
is: SBO:0000252
constant: false
is: P37837
is encoded by: hsa:6888
name: TALDO1
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaR DNDPt35m
modifier: MODEL1310110031#
name: dGDP transport via dADP antiport
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reversible: false
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_fb39d321_5d44_467d_b5bb_39012d83ee3d
type: Species
is encoded by: hsa:221
initial concentration: NaN
is: P43353
is: SBO:0000252
name: ALDH3B1
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaR RAI2
reversible: true
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176

metaM cit e
constant: false
is: CHEBI:16947
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: citrate(3-)
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
boundary condition: false

metaM m8mpdol U r
is: CHEBI:59093
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110031#
fast: false
type: Reaction

metaM dtdp n
is: CHEBI:58369
is: HMDB01274
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_61c4e640_3101_411d_947d_79bd16b6b41c
name: HAS1
type: Species
has only substance units: false
is: Q8IYH3
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:3036

http://identifiers.org/biomodels.db/MODEL1310110031#_3f285a8e_6eaf_48aa_be73_00c0c6a3a18e
has only substance units: false
is: E9PEI9
boundary condition: true
is encoded by: hsa:4047
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: LSS
type: Species

metaR FAOXC205C184x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR PUNP7
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
name: purine-nucleoside phosphorylase (Xanthosine)

metaM 3tetd7ecoa m
boundary condition: false
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
constant: false
is: HMDB05066
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247

metaR FAOXC225m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_be798867_b553_401e_ad1b_fafd1b7d08b8
name: RPIA
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:22934
is: SBO:0000252
is: P49247
has only substance units: false

metaM galside hs e
is: CHEBI:12947
initial concentration: 1.0
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: D-galactosyl-N-acylsphingosine

metaM prostgh2 c
is: HMDB01381
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: prostaglandin H2(1-)
is: CHEBI:57405
initial concentration: 1.0
has only substance units: false

metaM hs deg5 l
is: SBO:0000247
is: CHEBI:17895
boundary condition: false
name: heparan sulfate, degradation product 5
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
constant: false
has only substance units: false
is: HMDB00158
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_ebb5f9d0_5ee5_4a30_a799_12219048e961
name: HSD17B4
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: E9PB82
has only substance units: false
initial amount: NaN
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110031#_9d660f87_1d47_4208_a878_91c12769638f
has only substance units: false
is encoded by: hsa:1606
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: DGKA
is: P23743
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_52df1d4e_8049_46d2_ba73_3f76bb8a74e7
is encoded by: hsa:10087
type: Species
name: COL4A3BP
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9Y5P4
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_f5674670_1096_4339_9e62_d690f98f7220
is: Q9BWD1
is encoded by: hsa:39
constant: false
name: ACAT2
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r0517
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110031#

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_88cdb5ae_527e_4ae8_8331_029ff103873b
initial concentration: NaN
constant: false
is: Q9HAB8
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:79717
name: PPCS
boundary condition: true
has only substance units: false

metaR r0915
is described by: ECO:0000000
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_2629242a_1419_455e_a98e_3f0ec0b7cf3f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: BCKDHB
constant: false
is: P21953
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:594

metaR r2420
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR RE3624M
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
name: RE3624
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR CORE2GTg
is: SBO:0000176
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
type: Reaction
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus

metaR CSEPASEly
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)

metaM ile L c
initial amount: NaN
is: HMDB00172
has only substance units: false
type: Species
initial concentration: 1.0
name: L-isoleucine
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
constant: false
is: SBO:0000247

metaR PROSTGE2t2
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
fast: false
name: prostaglandin uniport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_157e693e_bb52_463d_a3d5_06bfa5006d66
initial amount: NaN
boundary condition: true
is: Q548A7
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:65010
constant: false
name: SLC26A6
is: SBO:0000252

metaM Asn X Ser Thr l
constant: false
notes: FORMULA: XH CHARGE: 0
is: HMDB00051
type: Species
is: CHEBI:28938
is: SBO:0000247
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: C01342
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM glc D r
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
is: HMDB00122
initial concentration: 1.0
boundary condition: false
constant: false
name: D-glucose
type: Species
is: CHEBI:4167
is: SBO:0000247

metaM bildglcur e
type: Species
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
is: CHEBI:58471
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_284c6fa7_8033_40e4_9422_834a72bb92c0
constant: false
type: Species
is: P40879
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC26A3
boundary condition: true
is encoded by: hsa:1811
is: SBO:0000252

metaM gpail hs c
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
is: CHEBI:17049
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
boundary condition: false
initial concentration: 1.0

metaR HS3ly
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
modifier: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
reversible: false

metaM 3octdece1coa c
name: 3-hydroxyoctadecenoylcoa
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: HMDB13336
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species

metaM sprm e
is: HMDB01256
constant: false
boundary condition: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
initial amount: NaN
type: Species
name: spermine(4+)
is: CHEBI:45725
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR RE1527M
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1527

metaM lnlncacoa c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06290
type: Species
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
initial amount: NaN
name: alpha-Linolenoyl-CoA
is: CHEBI:51985

http://identifiers.org/biomodels.db/MODEL1310110031#_7e10bcd9_8012_415c_909a_fbb13d0aea48
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4967
initial amount: NaN
is: B4E3E9
constant: false
initial concentration: NaN
is: SBO:0000252
name: OGDH

metaR FAOXC5C3x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR 13DAMPPOX
product: MODEL1310110031#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110031#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
fast: false
reversible: false
type: Reaction

metaM cit c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
initial concentration: 1.0
type: Species
is: HMDB00094
is: C00158
initial amount: NaN
is: CHEBI:16947

metaR r2100
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dcyt c
is: HMDB00014
is: C00881
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
is: SBO:0000247
name: Deoxycytidine
is: CHEBI:15698
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_e611c143_d66b_4fb0_8715_98b95afd2e68
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: PDE5A
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8654

metaM galside hs l
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947

metaR AG13T15g
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR RAI1
kinetic law: MODEL1310110031#
fast: false
name: retinal isomerase (11-cis)
reactant: MODEL1310110031#
reversible: true
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR r2539
is described by: ECO:0000000
reactant: MODEL1310110031#
name: Postulated transport reaction
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110031#
is: SBO:0000185

metaR AHEXASE2ly
reversible: false
kinetic law: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110031#_81d88f72_60d0_4fb8_bbaf_954f0bd95175
is encoded by: hsa:H77542
is: SBO:0000252
name: _H77542_1_r
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR r0672
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction

metaM g6p r
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: D-Glucose 6-phosphate
is: CHEBI:61548
has only substance units: false
is: C00092
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_8535dd43_b425_4e4e_a18d_9a75fbfd34fa
is encoded by: hsa:224
type: Species
is: P51648
constant: false
has only substance units: false
name: ALDH3A2
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_c49a024c_de50_4436_9adf_c0a2f82980e6
is: Q99714
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3028
name: HSD17B10
has only substance units: false
constant: false

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110031#

metaR MTHFD2
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110031#
name: methylenetetrahydrofolate dehydrogenase (NAD)
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
reversible: true
fast: false

metaR FAOXC123x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6844c7ff_87de_4549_968a_aad6679689e3
initial concentration: NaN
is encoded by: hsa:5152
has only substance units: false
name: PDE9A
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_3ef047dd_2e33_4fa8_bfe5_02b772b41c78
name: IK
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3550
is: Q13123
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaM ksi deg15 l
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 15
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
has only substance units: false

metaM ksi deg6 l
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 6
is: CHEBI:12936
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial concentration: 1.0
is: HMDB00143
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM glcur l
constant: false
name: D-glucuronate
is: CHEBI:15748
has only substance units: false
boundary condition: false
is: HMDB00127
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0

metaR r0671
kinetic law: MODEL1310110031#
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.22
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR r2538
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Utilized transport
product: MODEL1310110031#
is described by: ECO:0000000

metaR UDPDOLPT U
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.117

metaM bildglcur c
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
is: CHEBI:58471
constant: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
initial amount: NaN

metaM man6p c
boundary condition: false
type: Species
is: HMDB01078
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17369
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
name: D-Mannose 6-phosphate

http://identifiers.org/biomodels.db/MODEL1310110031#_24c1eea7_e2fb_4f5e_b264_0ca7bcdaf8fa
boundary condition: true
has only substance units: false
name: _AI024818_1_c
constant: false
is encoded by: hsa:AI024818
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_fd974791_ee74_4e1d_8699_21b9b3794bd2
constant: false
boundary condition: true
name: _AF116616_1_m
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AF116616

metaM gd3 hs g
boundary condition: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
is: SBO:0000247
type: Species
name: GD3
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28424
constant: false
has only substance units: false

metaM sebacid x
is: C08277
constant: false
is: SBO:0000247
is: HMDB00792
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
name: sebacicacid
type: Species
boundary condition: false
has only substance units: false

metaR ARACHCRNt
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110031#
type: Reaction
fast: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
reactant: MODEL1310110031#

metaM hdd2coa x
has only substance units: false
is: HMDB03945
type: Species
initial concentration: 1.0
is: SBO:0000247
name: (E)-hexadec-2-enoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
constant: false
is: CHEBI:61526

http://identifiers.org/biomodels.db/MODEL1310110031#_206d3145_f36d_444e_bdf8_684f84399580
constant: false
has only substance units: false
boundary condition: true
name: _AA278423_1_c
is encoded by: hsa:AA278423
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r2537
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Utilized transport
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_9168d83f_d7f3_41d5_a7c0_3f9672edde37
constant: false
initial amount: NaN
is encoded by: hsa:51079
name: NDUFA13
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9P0J0
type: Species

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM decdicoa c
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: decadienoylcoa
boundary condition: false
is: HMDB01168
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_b1d0f51d_bf30_48b8_b491_d17cbd0a72f5
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9BWD1
name: ACAT2
has only substance units: false
is encoded by: hsa:39
constant: false

metaM arachd c
is: HMDB01043
initial amount: NaN
constant: false
has only substance units: false
name: arachidonate
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110031#_e9dd37db_6220_4240_ab04_ff48dba30e6a
is: SBO:0000252
initial concentration: NaN
name: BAAT
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q14032
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110031#_9f76658d_8cbf_499f_9c69_a547cce4ac2e
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GNS
is: Q7Z3X3
has only substance units: false
constant: false
is encoded by: hsa:2799
type: Species
is: SBO:0000252

metaR r0512
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110031#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110031#

metaM glyc3p x
name: Glycerol 3-phosphate
is: HMDB00126
is: CHEBI:57597
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_def17a55_f16d_4782_82bc_2c948b19450d
initial amount: NaN
has only substance units: false
name: SLC23A2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:9962
initial concentration: NaN
is: Q9UGH3
is: SBO:0000252

metaM ksi deg26 l
has only substance units: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:58343
name: keratan sulfate I, degradation product 26
is: HMDB00061

http://identifiers.org/biomodels.db/MODEL1310110031#_059f64df_1398_4e3b_925f_c61bc13eb9b3
is encoded by: hsa:286016
boundary condition: true
constant: false
initial amount: NaN
name: TPI1P2
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM acgbgbside hs l
is: HMDB00215
boundary condition: false
has only substance units: false
name: beta GalNAc globoside
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17411
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_f9f11d46_39dd_4abc_80c4_23d41cc0cbf3
initial concentration: NaN
name: ENTPD2
is encoded by: hsa:954
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q5SPY7
type: Species
has only substance units: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR CHSTEROLt3
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: cholesterol intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110031#_ef864171_f904_4114_a7d4_c28245f8af57
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10229
name: COQ7
is: Q99807
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC1811603m
name: Beta oxidation fatty acid
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110031#_d6ad793d_e033_4c99_9c4d_156e1b01a83a
is: SBO:0000252
name: GGT5
boundary condition: true
initial amount: NaN
is: P36269
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2687

metaR GLCNACASE4ly
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110031#
reversible: false
fast: false

metaR FAOXC11C9m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR OROTGLUt
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: OROTGLUt
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
fast: false

metaM hs deg9 l
initial concentration: 1.0
is: CHEBI:18268
name: heparan sulfate, degradation product 9
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB06355
boundary condition: false
constant: false
initial amount: NaN

metaR r1150
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
name: Facilitated diffusion
reversible: false
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000

metaR DNDPt9m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: false
name: dADP transport via dTDP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM 3ivcrn c
is: C05998
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C12H23NO5 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870

http://identifiers.org/biomodels.db/MODEL1310110031#_3cb45b13_a701_438d_9eb7_7d444fecc3d4
is encoded by: hsa:4831
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: NME2
is: P22392
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR PUNP1
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
name: purine-nucleoside phosphorylase (Adenosine)
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269

metaR CHSTEROLt1
product: MODEL1310110031#
reversible: true
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
name: cholesterol intracellular transport
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is: SBO:0000185

metaM arachd e
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: SBO:0000247
name: arachidonate
type: Species
is: CHEBI:32395
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01043
constant: false

metaR NCKt
fast: false
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
modifier: MODEL1310110031#
reversible: true
name: Na+/Ca2+-K+ exchange
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR S6TASE11ly
reversible: true
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110031#
product: MODEL1310110031#

metaM pa hs m
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
name: phosphatidate(2-)
is: CHEBI:57739
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR FUCtly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
name: L-fucose efflux from lysosome
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM pa hs n
is: SBO:0000247
name: phosphatidate(2-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57739
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110031#_abf0277f_edd5_4b1f_983b_1f793739083d
is: Q16836
name: HADH
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:3033

metaR S3TASE1ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction

metaM cit m
type: Species
name: Citrate
is: C00158
is: HMDB00094
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
is: CHEBI:16947
boundary condition: false

metaM ile L e
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17191
is: HMDB00172
name: L-isoleucine
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false

metaM pan4p m
type: Species
is: HMDB01416
is: CHEBI:47942
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

http://identifiers.org/biomodels.db/MODEL1310110031#_6cfcb105_57eb_47eb_bcf2_94a16f516a58
is: P00352
is encoded by: hsa:216
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: ALDH1A1

metaM 2mop c
initial amount: NaN
name: 2-methyl-3-oxopropanoate
has only substance units: false
is: SBO:0000247
is: HMDB01172
constant: false
initial concentration: 1.0
is: CHEBI:57700
boundary condition: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

metaR CHSTEROLt2
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
reversible: true
type: Reaction
name: cholesterol intracellular transport
kinetic law: MODEL1310110031#

metaR S6TASE10ly
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false

metaM lnlncg l
name: gamma-linolenate
is: SBO:0000247
initial concentration: 1.0
is: HMDB03073
is: CHEBI:32391
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_c5912996_db8c_4c4e_b2c1_95850bb5b15f
type: Species
is encoded by: hsa:27165
has only substance units: false
initial amount: NaN
name: GLS2
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR RE3421R
name: RE3421
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:

metaM glyb c
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
boundary condition: false
is: HMDB00043
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:17750
is: SBO:0000247
initial amount: NaN

metaM 3ivcrn e
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
is: HMDB13336
type: Species
initial amount: NaN
notes: FORMULA: C12H23NO5 CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_89b41e26_7fce_4236_9d9a_46650332e34a
is: SBO:0000252
initial amount: NaN
name: SLC25A1
constant: false
initial concentration: NaN
is encoded by: hsa:6576
is: D9HTE9
boundary condition: true
has only substance units: false
type: Species

metaR FAOXC123m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR 34HPLFM
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
name: 3-(4-hydroxyphenyl-)lactate formation
is: SBO:0000176
type: Reaction
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#

metaR HISCAT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR ACt2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
name: acetate mitochondrial transport via proton symport
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#

metaR PEPCK
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
name: Phosphoenolpyruvate carboxykinase (GTP)
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.32

metaR DAGKn hs
reactant: MODEL1310110031#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
type: Reaction

metaM acgbgbside hs g
has only substance units: false
is: CHEBI:17411
boundary condition: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: beta GalNAc globoside
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00215

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM m1mpdol L c
constant: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR NDP7g
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110031#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#

metaM malcoa r
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
is: HMDB01175
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: malonyl-CoA(4-)
has only substance units: false
is: CHEBI:57384

metaM 56dthm m
is: HMDB00079
initial amount: NaN
is: SBO:0000247
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
constant: false
name: 5,6-dihydrothymine
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR DURIt
is: SBO:0000185
product: MODEL1310110031#
name: deoxyuridine transport via diffusion
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR MTHFC
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
name: methenyltetrahydrofolate cyclohydrolase
is described by: ECO:0000134
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.1.5

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
is described by: ECO:0000269
modifier: MODEL1310110031#

metaR EX 3ddcrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR LGTHL
reversible: false
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: lactoylglutathione lyase
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is version of: http://identifiers.org/ec-code/4.4.1.5
kinetic law: MODEL1310110031#

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_df233c6d_4230_4c6c_b96d_d435c0392a35
initial concentration: NaN
constant: false
is: Q86YW0
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:89869
name: PLCZ1

metaR PUNP4
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is described by: ECO:0000000

metaR DHORD9
reversible: false
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM core3 g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: Core 3
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: CHEBI:16250

http://identifiers.org/biomodels.db/MODEL1310110031#_fb28d785_aa9d_4c2c_a738_5548146097e0
is: Q16720
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ATP2B3
type: Species
is encoded by: hsa:492
constant: false

metaM hexdpencoa x
has only substance units: false
is: HMDB02288
name: 2,4,7,10,13-hexadecapentaenoylcoa
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM CE5117 m
is: CHEBI:57923
is: SBO:0000247
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
boundary condition: false
initial amount: NaN
type: Species

metaM 3octdece1coa m
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3-hydroxyoctadecenoylcoa
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355

metaR MTHFD
type: Reaction
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reactant: MODEL1310110031#
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110031#
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.1.5

metaR RE0830N
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000176
name: RE0830
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#

metaR CHOLK
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
is described by: ECO:0000269
name: Choline kinase
reactant: MODEL1310110031#

metaM 6pgc r
name: 6-phosphonatooxy-D-gluconate
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58759
is: SBO:0000247
boundary condition: false
is: HMDB01316
type: Species
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
has only substance units: false

metaM xylt c
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
is: HMDB02917
initial concentration: 1.0
name: xylitol
is: CHEBI:17151
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaR PUNP5
modifier: MODEL1310110031#
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Inosine)

metaM 4mptnl m
is: CHEBI:17998
type: Species
is: HMDB01318
has only substance units: false
boundary condition: false
name: 4-methylpentanal
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_4bc32841_b829_4f35_b739_dcea64e4e4a8
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:91373
is: Q3KQV9
initial amount: NaN
name: UAP1L1
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_5c88a036_4c29_48de_9786_0549f4dcb171
type: Species
initial concentration: NaN
constant: false
is: O95168
boundary condition: true
name: NDUFB4
is encoded by: hsa:4710
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR FAEL183
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
product: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000000

metaR NACHEXA10ly
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110031#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
fast: false
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM s2l2n2m2mn l
has only substance units: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:50570
is: HMDB06529
type: Species
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: SBO:0000247
initial concentration: 1.0

metaR MAL Lte
fast: false
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: true
name: Transport of L-malate

metaR MI13PP
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
name: inositol-1,3-bisphosphate 3-phosphatase
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
reversible: false

metaM lnlncg r
boundary condition: false
is: HMDB03073
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32391
type: Species
has only substance units: false
name: gamma-linolenate

http://identifiers.org/biomodels.db/MODEL1310110031#_cd9f998a_5021_42e4_b518_d403633e4ff4
initial amount: NaN
type: Species
has only substance units: false
is: P04062
is encoded by: hsa:2629
name: GBA
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_4c921d75_39df_4dc8_83ac_97aaad6e2a0b
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7841
name: MOGS
is: F5H6D0
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR S6TASE1ly
is described by: ECO:0000000
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
type: Reaction
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_62d96c04_2db9_4b33_b47b_505930643af4
initial amount: NaN
is: SBO:0000252
name: HMGCS1
initial concentration: NaN
is encoded by: hsa:3157
constant: false
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_453402c6_8956_46b2_8eef_89320121a039
name: GSR
is: SBO:0000252
is encoded by: hsa:2936
constant: false
type: Species
has only substance units: false
is: P00390
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR SEBACIDTD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR r1156
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110031#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

metaR PUNP3
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
name: purine-nucleoside phosphorylase (Guanosine)

http://identifiers.org/biomodels.db/MODEL1310110031#_a278a898_bcc4_4c92_8f6d_1598200a296f
type: Species
initial amount: NaN
is encoded by: hsa:4645
is: Q9H6Y6
initial concentration: NaN
name: MYO5B
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_7d4ac40c_431a_43d2_b57d_cdec81cc9eb9
name: AMT
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:275
is: SBO:0000252
is: P48728

http://identifiers.org/biomodels.db/MODEL1310110031#_7248e37d_5e13_4c62_88fd_9452bb4e320d
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: PDE9A

metaM camp c
constant: false
is: CHEBI:58165
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00058
boundary condition: false
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM retinol 9 cis c
is: SBO:0000247
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false
is: HMDB06217
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: 9-cis-retinol
initial concentration: 1.0

metaR FAOXC205C185m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR UDPDOLPT L
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000176
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.117
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
modifier: MODEL1310110031#

metaM 3octdece1crn e
initial amount: NaN
initial concentration: 1.0
is: HMDB13336
notes: FORMULA: C25H47NO5 CHARGE: 0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false

metaM ksii core2 pre3 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 3
constant: false
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR DURItn
type: Reaction
name: deoxyuridine transport in nucleus
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#

metaM xol27oh r
initial concentration: 1.0
name: 26-hydroxycholesterol
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
is: CHEBI:17703
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_3ed1d38d_c963_4395_9267_973e24ae0cad
boundary condition: true
is encoded by: hsa:56913
name: C1GALT1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q9NS00
has only substance units: false

metaM dectricoa x
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
name: 2,4,7-decatrienoylcoa

metaR PYAM5POr
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110031#
reactant: MODEL1310110031#
name: pyridoxamine 5'-phosphate oxidase
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_4d52ba9c_d16e_41e9_b906_67dfc7a0043c
boundary condition: true
initial amount: NaN
name: ADH6
constant: false
is: SBO:0000252
is encoded by: hsa:130
initial concentration: NaN
has only substance units: false
type: Species
is: P28332

http://identifiers.org/biomodels.db/MODEL1310110031#_6e069901_7549_42a4_a1a9_85201d4697ed
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI694761
type: Species
initial amount: NaN
is: SBO:0000252
name: _AI694761_1_c

metaM pa hs c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
constant: false
boundary condition: false
name: phosphatidate(2-)
initial concentration: 1.0
is: SBO:0000247

metaM sbt D e
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: D-glucitol
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
boundary condition: false
type: Species

metaM acgbgbside hs c
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00215
is: CHEBI:17411
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: beta GalNAc globoside

metaR FAOXC16C14m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_89ffce33_7729_43ad_9bc1_df0adc945115
name: ATP5A1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: B4DY56
initial concentration: NaN
is encoded by: hsa:498
initial amount: NaN

metaM ksii core2 pre5 g
is: HMDB00175
is: C00130
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 5
boundary condition: false
has only substance units: false
constant: false
type: Species

metaM sebacid c
is: C08277
initial amount: NaN
type: Species
is: HMDB00792
has only substance units: false
is: SBO:0000247
constant: false
name: sebacicacid
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false
initial concentration: 1.0

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM 3octdece1crn c
initial concentration: 1.0
initial amount: NaN
is: HMDB13336
notes: FORMULA: C25H47NO5 CHARGE: 0
has only substance units: false
type: Species
constant: false
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_b2e6b5e5_b2ec_4e9b_bace_b7e85919b8d2
initial concentration: NaN
is: F5H2Y9
is encoded by: hsa:8854
name: ALDH1A2
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r2109
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110031#
is: SBO:0000185
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110031#
fast: false

metaR ELAIDCRNt
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#
name: transport into the mitochondria (carnitine)
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

metaM hpdcacoa m
name: heptadecanoyl coa
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_eaf3af69_0f33_4684_99ca_d74ce26f75ca
initial amount: NaN
is encoded by: hsa:175
is: SBO:0000252
boundary condition: true
has only substance units: false
name: AGA
is: P20933
initial concentration: NaN
type: Species
constant: false

metaR CYTK2n
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110031#

metaR r0226
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
fast: false
reactant: MODEL1310110031#
type: Reaction

metaR r1750
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction

metaM 5pmev c
is: HMDB01343
is: SBO:0000247
type: Species
name: (R)-5-phosphonatomevalonate(3-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bb8a9e06_4c63_415b_8433_6f982bbaa758
constant: false
is encoded by: hsa:50808
name: AK3
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: E7ET30

http://identifiers.org/biomodels.db/MODEL1310110031#_75560245_dc30_4ea9_8b49_54eff58e88c0
is: SBO:0000252
constant: false
has only substance units: false
name: ATP5G3
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:518
initial amount: NaN

metaR GLYCTDle
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
fast: false
name: difussion of glycerol accross the brush border membrane
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110031#

metaM biocyt m
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
is: HMDB03134
has only substance units: false
is: SBO:0000247
type: Species
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

metaM 34dhpha c
is: SBO:0000247
is: CHEBI:17612
constant: false
initial amount: NaN
boundary condition: false
name: (3,4-dihydroxyphenyl)acetate
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: HMDB01336
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_95de6901_adf1_4a33_ae1d_43cd51c0941f
is: Q05C14
is: SBO:0000252
name: FOLR3
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2352

metaR ASNCYSNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
is: SBO:0000185
product: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_bc40659f_a393_49e2_8c89_bcac5bb26752
type: Species
is encoded by: hsa:10246
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O00624
has only substance units: false
constant: false
name: SLC17A2
is: SBO:0000252

metaR NACHEXA20ly
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b1e4bd3b_4ee1_46e6_a246_4d7b00f5cb4f
type: Species
boundary condition: true
name: _AA576959_1_c
is encoded by: hsa:AA576959
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR KSII CORE4tly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is described by: ECO:0000000

metaM ksi deg3 l
is: SBO:0000247
is: CHEBI:50570
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
name: keratan sulfate I, degradation product 3
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB06529
initial amount: NaN
constant: false
type: Species

metaM ile L m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-isoleucine
type: Species
is: HMDB00172
has only substance units: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
constant: false

metaR FAOXC102C101x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR NAt3 1
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
name: sodium proton antiporter (H:NA is 1:1)
is described by: ECO:0000269
is: SBO:0000185

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
initial amount: NaN
constant: false
is: CHEBI:32391
initial concentration: 1.0
type: Species
is: SBO:0000247
name: gamma-linolenate
boundary condition: false
has only substance units: false

metaM HC02187 e
boundary condition: false
constant: false
initial amount: NaN
name: reverse-triiodthyronine
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR RE0915E
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE0915
product: MODEL1310110031#
modifier: MODEL1310110031#

metaM 4mptnl e
initial concentration: 1.0
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
is: CHEBI:17998
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01318
has only substance units: false
name: 4-methylpentanal
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_44c4f48c_103d_4c60_9b69_9039aca837c0
is: P04844
initial concentration: NaN
type: Species
is: SBO:0000252
name: RPN2
initial amount: NaN
constant: false
is encoded by: hsa:6185
has only substance units: false
boundary condition: true

metaM mgacpail hs r
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
has only substance units: false
is: CHEBI:7896
is: C00249
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00220
boundary condition: false
constant: false

metaR GCALDD
is: SBO:0000176
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110031#
fast: false
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaR FAS180COA
name: fatty-acyl-CoA synthase (n-C18:0CoA)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM HC00229 e
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Isomaltose
has only substance units: false
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
name: fatty-acid--CoA ligase (tetradecanoate)
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
is: SBO:0000176
fast: false
product: MODEL1310110031#

metaR KHte
reactant: MODEL1310110031#
type: Reaction
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000185
name: KHte
product: MODEL1310110031#
reversible: true

metaR r0377
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110031#
fast: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
type: Reaction

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
kinetic law: MODEL1310110031#
fast: false
name: geranyltranstransferase
reactant: MODEL1310110031#
is described by: ECO:0000134
modifier: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#

metaM Rtotal3 e
is: SBO:0000247
boundary condition: false
is: HMDB00244
name: R total 3 position
is: CHEBI:3554
has only substance units: false
initial amount: NaN
is: C00255
notes: FORMULA: CO2FULLR3 CHARGE: -1
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_80088abe_5d10_4156_8c25_759285020dbb
initial concentration: NaN
type: Species
is: Q6IBC4
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFS6
is encoded by: hsa:4726
initial amount: NaN
has only substance units: false

metaM 5mta c
name: 5-Methylthioadenosine
is: C00170
boundary condition: false
constant: false
is: HMDB01173
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
initial amount: NaN
type: Species
is: CHEBI:17509
is: SBO:0000247

metaM cs b deg3 l
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:21338
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB02704
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110031#_201bb62f_23b2_4c75_8b01_f9a0ccd4125f
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6390
is: P21912
name: SDHB
is: SBO:0000252

metaM ksi pre24 g
initial concentration: 1.0
is: HMDB00175
boundary condition: false
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 24
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
is: CHEBI:58053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e530cdc2_dcfc_402c_aa03_614ccd61d4f4
name: SLC26A6
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:65010
initial amount: NaN
boundary condition: true
is: Q9NQU1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_3af49212_63cb_4c77_9299_4be0e1c0a132
name: ETFA
boundary condition: true
initial amount: NaN
has only substance units: false
is: P13804
is: SBO:0000252
is encoded by: hsa:2108
constant: false
initial concentration: NaN
type: Species

metaM fuc1p L c
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial amount: NaN
type: Species
name: L-Fucose 1-phosphate
has only substance units: false
is: CHEBI:28319
initial concentration: 1.0
boundary condition: false
is: HMDB01265
constant: false
is: SBO:0000247

metaR VALTA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
name: valine transaminase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110031#
reversible: true

metaR NAHCO3 HCLt
is described by: ECO:0000269
name: bicarbonate transport (HCl/NaHCO3 exchange)
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

metaM ksii core4 pre2 g
is: C00130
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00175
is: SBO:0000247
type: Species
is: CHEBI:58053
name: keratan sulfate II boisynthesis, precursor 2

http://identifiers.org/biomodels.db/MODEL1310110031#_2908aad9_134f_4c96_9ddd_82781f6e08eb
name: AGPAT3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:56894
has only substance units: false
is: Q9NRZ7

metaR FAOXC165C164x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaR OCT11EFATP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR CYSASNNaEx
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110031#
reversible: false
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_c88fa85d_8cea_4b34_8677_958544bf0bf7
type: Species
initial amount: NaN
is encoded by: hsa:2592
is: B2RAT6
constant: false
initial concentration: NaN
is: SBO:0000252
name: GALT
has only substance units: false
boundary condition: true

metaR r1751
modifier: MODEL1310110031#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
fast: false

metaM memgacpail hs r
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:15809
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0

metaR ACOAD9m
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
modifier: MODEL1310110031#

metaR EX nad LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

metaM xol27oh m
name: 26-hydroxycholesterol
is: CHEBI:17703
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_3cddf6ed_fab8_4dd4_b657_9b1dee1bbe48
is: SBO:0000252
boundary condition: true
is encoded by: hsa:115111
name: SLC26A7
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR FADtx
name: FAD transporter, peroxisomal
is: SBO:0000185
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
type: Reaction
fast: false

metaR r1754
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
type: Reaction
fast: false

metaM HC02187 c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28774
name: reverse-triiodthyronine

metaR TRDR
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_50ad87a9_d346_4f3b_a5cf_57343bd7ed4b
is: SBO:0000252
boundary condition: true
name: AUH
type: Species
is: Q13825
is encoded by: hsa:549
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6e36e8d2_a5ef_450a_9736_e21d44f56ffd
constant: false
type: Species
initial concentration: NaN
name: IVD
boundary condition: true
is encoded by: hsa:3712
is: SBO:0000252
initial amount: NaN
is: B3KVI7
has only substance units: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR STS1
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2
name: Steryl-sulfatase
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_a85697cc_f728_4291_862f_bf169ed27a62
has only substance units: false
name: _AV713053_1_m
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AV713053
initial concentration: NaN

metaM elaidcrn m
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: Elaidic carnitine
boundary condition: false
is: SBO:0000247
is: HMDB06464

metaM sbt D c
boundary condition: false
initial concentration: 1.0
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
is: HMDB00247
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
type: Species

metaM 5mta e
is: CHEBI:17509
is: C00170
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01173
notes: FORMULA: C11H15N5O3S CHARGE: 0
name: 5-Methylthioadenosine
boundary condition: false
constant: false
initial amount: NaN

metaR ACALDt
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
fast: false

metaR GLYt7 311 r
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
fast: false
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110031#

metaM 3m4hpga m
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7909
has only substance units: false
constant: false
is: SBO:0000247
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: HMDB04061
boundary condition: false
type: Species
is: C05583
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583

http://identifiers.org/biomodels.db/MODEL1310110031#_72127b8c_61eb_461c_9d0a_9859e6782f29
is: O60476
initial concentration: NaN
is encoded by: hsa:10905
has only substance units: false
boundary condition: true
name: MAN1A2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaR NACHEX11ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_c550076b_6391_4a2a_9103_54c19454babd
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: CPT1B
is: E9PCP2
is encoded by: hsa:1375

http://identifiers.org/biomodels.db/MODEL1310110031#_5141b826_d1e7_4602_a7bf_ba32b8b138eb
name: NT5C
constant: false
has only substance units: false
is: Q8TCD5
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:30833

metaM hpdcacoa c
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
boundary condition: false
is: HMDB06497
initial amount: NaN

metaR RE3301C
is described by: ECO:0000000
modifier: MODEL1310110031#
name: RE3301
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
type: Reaction
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: true
is: SBO:0000176

metaR CRVNCtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM octdececoa c
initial amount: NaN
name: octadecenoylcoa
is: HMDB06351
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f17a3ce5_5619_48ba_a474_1b33e5411eb2
initial concentration: NaN
name: ACSS1
has only substance units: false
initial amount: NaN
is: Q9NUB1
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:84532
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_21066c21_ce30_471b_b9cd_252ba84c161b
initial amount: NaN
name: SLC25A1
initial concentration: NaN
is encoded by: hsa:6576
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: D9HTE9
constant: false

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
name: zymosterol
has only substance units: false
is: CHEBI:18252
is: HMDB06271
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1aab6d86_c575_4e7c_b1c7_b8c13ba0b7be
initial concentration: NaN
is encoded by: hsa:124935
is: SBO:0000252
boundary condition: true
is: Q8N370
name: SLC43A2
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_cbaa4b2c_a0a9_43e1_adef_8c3c6d70625e
is: SBO:0000252
has only substance units: false
constant: false
name: GOT2
type: Species
initial concentration: NaN
is encoded by: hsa:2806
is: P00505
boundary condition: true
initial amount: NaN

metaR FAOXC165C164m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR ABUTD
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_b9a9f705_aad0_4394_a2f5_3a2158c0e88a
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: COQ3
is encoded by: hsa:51805
initial amount: NaN
is: Q9NZJ6

metaR MCLACCYSR
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
product: MODEL1310110031#
fast: false
name: 3-mercaptolactate:cysteine reductase
reactant: MODEL1310110031#
type: Reaction

metaR r2103
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR IZPN
reactant: MODEL1310110031#
name: Imidazolonepropionase
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaM xylu L c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
name: L-xylulose
is: HMDB00751
has only substance units: false
initial amount: NaN
is: CHEBI:17399

http://identifiers.org/biomodels.db/MODEL1310110031#_e1027079_ade8_4fe8_94db_aa68aa36de0b
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: SLC3A1
initial concentration: NaN
type: Species
is: Q07837
is encoded by: hsa:6519

http://identifiers.org/biomodels.db/MODEL1310110031#_9c4bf26b_771f_4062_88a6_79b798117b4f
name: NAGLU
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4669
initial amount: NaN
has only substance units: false
type: Species
is: P54802

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_431d531f_f6c9_462a_909f_079a654346f5
is encoded by: hsa:2990
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P08236
is: SBO:0000252
name: GUSB

metaM 3tetd7ecoa c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB05066
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_209d2452_f961_41e5_9c86_14b0d3b9f820
is encoded by: hsa:4907
is: SBO:0000252
type: Species
has only substance units: false
name: NT5E
boundary condition: true
constant: false
initial amount: NaN
is: P21589
initial concentration: NaN

metaM Lcystin e
boundary condition: false
name: L-cystine
initial amount: NaN
is: HMDB00192
is: SBO:0000247
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
has only substance units: false
type: Species
initial concentration: 1.0

metaR FAOXC14C14OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9904b31a_10df_41e3_8e88_cdef303dc35c
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: B3GNT2
is: Q9NY97
is encoded by: hsa:10678
is: SBO:0000252
initial concentration: NaN

metaM s2l2n2m2masn e
is: SBO:0000247
initial amount: NaN
is: CHEBI:3554
boundary condition: false
constant: false
is: C00255
has only substance units: false
initial concentration: 1.0
is: HMDB00244
notes: FORMULA: C84H135N6O61X CHARGE: -2
type: Species
name: de-Fuc form of PA6

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true

metaM ser D e
type: Species
is: HMDB03406
is: CHEBI:16523
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: D-serine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaM m7mpdol L r
initial concentration: 1.0
is: CHEBI:37636
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
has only substance units: false
is: SBO:0000247

metaR r2101
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000185

metaR ACNAM9PL2
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.56
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
fast: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR FAOXC164C163x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM dectricoa m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
constant: false
initial concentration: 1.0
name: 2,4,7-decatrienoylcoa
type: Species
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM malcoa c
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false
is: CHEBI:57384
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01175
is: SBO:0000247
boundary condition: false
name: Malonyl-CoA
is: C00083

metaM 4mptnl c
type: Species
is: HMDB01318
boundary condition: false
has only substance units: false
constant: false
name: 4-methylpentanal
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: SBO:0000247
is: CHEBI:17998

http://identifiers.org/biomodels.db/MODEL1310110031#_956f2143_380c_4a94_b3d8_53790fde948a
is encoded by: hsa:513
type: Species
boundary condition: true
initial amount: NaN
name: ATP5D
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM vacccoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06521
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: vaccenyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e5f5b939_dcf8_4f91_ad7e_57278a6ae6d8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:374907
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: B3GNT8

metaM C05280 m
is: HMDB03952
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28002
is: SBO:0000247
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaR FAOXC181C161x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR GALASE9ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110031#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM 2octdectecoa m
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
type: Species

metaR r2102
modifier: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR PSt3
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
name: phosphatidylserine transport
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR G14T15g
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_0280f3d9_e369_4aea_98ac_ca42ee52ef6b
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:55825
has only substance units: false
is: Q9BY49
initial concentration: NaN
name: PECR
boundary condition: true

metaR r0668
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.19
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_9dc5ad8b_969b_4ec0_aea3_d8928c4a6f1f
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: P23677
initial amount: NaN
is encoded by: hsa:3706
name: ITPKA

http://identifiers.org/biomodels.db/MODEL1310110031#_0de9d439_f624_4d67_b712_a5676d01ad25
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P04843
name: RPN1
is encoded by: hsa:6184
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_ca8b591b_206e_4c26_bcaa_12d3a82b7de6
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: SLC8A3
is encoded by: hsa:6547
initial concentration: NaN

metaR THCHOLSTOICtm
is: SBO:0000185
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_1a78ba6a_b546_4b59_8b0d_0d521e3170c3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI915649_1_c
is encoded by: hsa:AI915649
has only substance units: false
boundary condition: true
constant: false

metaM arachcoa m
is: HMDB04258
is: CHEBI:15527
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: arachidyl coenzyme A
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_26f9746f_4da1_4e47_9fd3_76fd4bf08992
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI972237
name: _AI972237_1_c
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_7e0d2ee2_7d1c_4656_bc1a_c171c548d231
initial concentration: NaN
name: BTD
has only substance units: false
is: P43251
is encoded by: hsa:686
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM dd3coa x
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB04257
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
name: 3-dodecenoylcoa

metaR r2107
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction

metaM galside hs c
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
name: D-galactosyl-N-acylsphingosine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_41084877_1074_4be2_bb23_4db72a904ab6
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5288
type: Species
is: SBO:0000252
constant: false
name: PIK3C2G
is: O75747
boundary condition: true

metaM gsn c
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
has only substance units: false
boundary condition: false
is: CHEBI:16750
constant: false
is: C00387
initial concentration: 1.0
name: Guanosine
is: HMDB00133
initial amount: NaN
is: SBO:0000247
type: Species

metaM glcur e
type: Species
is: CHEBI:15748
name: D-glucuronate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110031#_950339ba_3348_4b1f_a6b4_a9ec832cf3d2
initial concentration: NaN
is encoded by: hsa:9197
constant: false
is: O00400
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: SLC33A1
has only substance units: false

metaR C142OHe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_49d1f5e0_a973_4b28_965a_bf707ef70084
boundary condition: true
is encoded by: hsa:79053
constant: false
is: A6NDW6
name: ALG8
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM gsn e
is: CHEBI:16750
has only substance units: false
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: C00387
is: HMDB00133

metaM lnlncg c
has only substance units: false
initial concentration: 1.0
name: gamma-linolenate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:32391
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
type: Species

metaR FAOXC163C143m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
reversible: false

metaR r0669
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reactant: MODEL1310110031#
fast: false
reversible: false
is: SBO:0000176

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f6ad766c_be2e_4681_adf1_4f19e362e2fe
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:522
is: Q6NZ59
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: ATP5J

metaR r2108
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_2fffc0b2_a60b_41d1_8d95_edd94b061908
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:219
is: SBO:0000252
type: Species
initial amount: NaN
name: ALDH1B1
is: P30837
initial concentration: NaN

metaM arachd x
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
constant: false
is: CHEBI:32395
has only substance units: false
initial amount: NaN
name: arachidonate
is: HMDB01043
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_8d0110ce_3ebe_4e70_aed5_740e4e0acebc
has part: P22392
is encoded by: hsa:4830
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4831
name: NME1:NME2
has part: P15531
constant: false
is: SBO:0000297
initial concentration: NaN

metaR r0666
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1

metaR 3AIBtm
name: 3-amino-isobutyrate transport, mitochondrial
type: Reaction
product: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2bc57c57_de52_4bfd_9c00_a343b12f98e6
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O75106
is encoded by: hsa:314
constant: false
name: AOC2

http://identifiers.org/biomodels.db/MODEL1310110031#_7af78335_d660_48bc_a6b6_6198956b3a53
constant: false
name: TXNRD3
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:114112
is: Q86VQ6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r2105
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110031#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
product: MODEL1310110031#
reactant: MODEL1310110031#

metaM m2mpdol L c
initial concentration: 1.0
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
is: SBO:0000247
is: CHEBI:28049
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaR RETI2
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol isomerase (9-cis)
product: MODEL1310110031#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_8abf6c0c_a05e_488b_9472_72293ffda4cc
constant: false
initial amount: NaN
is: O95573
has only substance units: false
boundary condition: true
name: ACSL3
type: Species
is encoded by: hsa:2181
initial concentration: NaN
is: SBO:0000252

metaM cmpacna n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01176
constant: false
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
type: Species

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:58335
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)
is: SBO:0000247
has only substance units: false

metaR 4HBZCOAFm
reactant: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: 4-hydroxybenzoyl-CoA formation
product: MODEL1310110031#

metaM CE5119 m
boundary condition: false
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
constant: false
type: Species
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM retinol 9 cis e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17336
type: Species
constant: false
is: HMDB06217
initial amount: NaN
name: 9-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false

metaR CSPG Atly
reversible: false
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate A transport, extracellular to lysosome
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction

metaR SERASNNaEx
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false

metaM 2dp6mobq m
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
type: Species
is: CHEBI:50773
initial amount: NaN
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaR HSAT3ly
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaR C142OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaM lnlncacoa m
initial concentration: 1.0
name: alpha-Linolenoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: CHEBI:51985
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06290

metaR RE1135C
reversible: true
type: Reaction
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
name: RE1135
modifier: MODEL1310110031#
is: SBO:0000176

metaM glcur c
constant: false
is: HMDB00127
has only substance units: false
initial amount: NaN
name: D-glucuronate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15748
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaM 3mox4hoxm m
initial amount: NaN
name: 3-Methoxy-4-hydroxymandelate
boundary condition: false
is: CHEBI:27622
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00291

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
name: butyrate
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00039
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR RETI1
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
name: retinol isomerase (11-cis)
reactant: MODEL1310110031#
reversible: true

metaM HC01401 m
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:27668

http://identifiers.org/biomodels.db/MODEL1310110031#_e57701ca_91cc_43c1_af19_914382d3fc82
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P24311
name: COX7B
type: Species
has only substance units: false
is encoded by: hsa:1349

metaR r2106
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110031#_b4d80821_7897_45a7_b729_74a323acfe94
name: _AA081045_1_m
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AA081045
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR S6T6g
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110031#

metaR NADtx
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110031#
reversible: true
type: Reaction
fast: false
product: MODEL1310110031#
name: transport of NAD into peroxisome
is: SBO:0000185

metaM Lcystin c
type: Species
name: L-cystine
is: SBO:0000247
is: HMDB00192
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
has only substance units: false
is: CHEBI:16283
initial concentration: 1.0
boundary condition: false

metaR AG13T18g
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110031#
type: Reaction
fast: false

metaM adrn c
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: adrenic acid
boundary condition: false
is: CHEBI:53487
is: HMDB02226

metaM noncoa m
initial amount: NaN
is: C01942
is: HMDB13028
has only substance units: false
type: Species
name: nonanoylcoa
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR ACOAD10m
modifier: MODEL1310110031#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110031#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
is described by: ECO:0000269

metaM dadp c
constant: false
has only substance units: false
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
type: Species
is: C00206
boundary condition: false
initial amount: NaN
name: dADP
is: SBO:0000247
is: CHEBI:57667

http://identifiers.org/biomodels.db/MODEL1310110031#_bb84ba8b_5b41_4610_b129_303b8370dc96
is: A8K092
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:498
name: ATP5A1
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM HC02210 c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: prostaglandin-d3
type: Species
is: CHEBI:34939

metaR ACONTm
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000134
name: Aconitate hydratase
type: Reaction
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#

metaM for e
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
name: formate
is: CHEBI:15740
constant: false
initial amount: NaN
is: HMDB00142

metaR SPODMn
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: superoxide dismutase, nuclear
type: Reaction
reversible: false
is: SBO:0000176
fast: false

metaM pi e
is: CHEBI:43474
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: C00009
is: HMDB00973

metaR r0525
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
is: SBO:0000176
fast: false

metaR PCHOLPm hs
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
reversible: false
name: choline phosphatase
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR ALAtN1
is: SBO:0000185
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
name: Alanine transport (Na, H coupled)
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR GLCAASE1ly
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_50ac6ade_6c69_4545_9765_9eb42ff707a1
is: O43678
has only substance units: false
is encoded by: hsa:4695
boundary condition: true
name: NDUFA2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR UDPGLCter
is described by: ECO:0000000
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#

metaM 3hexdtetcoa m
name: 3,7,10,13-hexadecatetraenoylcoa
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02288
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species

metaR FRDPtcr
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reversible: true
is described by: ECO:0000134
fast: false
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6cfa8d5b_439a_4944_91e7_d8411d49bc31
is encoded by: hsa:1806
has only substance units: false
is: Q12882
is: SBO:0000252
constant: false
type: Species
name: DPYD
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM glutcoa m
is: SBO:0000247
has only substance units: false
is: CHEBI:57378
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01339
boundary condition: false
name: glutaryl-CoA(5-)

metaM apoC Lys m
initial amount: NaN
is: CHEBI:32551
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00182
type: Species
name: Apocarboxylase (Lys residue)

metaR SPODMm
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
name: superoxide dismutase
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
fast: false
is described by: ECO:0000304

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
name: UMP kinase
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_e31bf164_2fc4_4239_b5d8_41efe84ba027
type: Species
has only substance units: false
is: O75947
initial concentration: NaN
is: SBO:0000252
name: ATP5H
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:10476

metaR FATP6t
modifier: MODEL1310110031#
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_d9003bb3_a4bc_4ac4_809f_c4c2f02fbd0f
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P30084
has only substance units: false
name: ECHS1
is encoded by: hsa:1892
constant: false

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_c34b3f53_a84b_4500_a5bd_0702e6befc37
has only substance units: false
initial amount: NaN
boundary condition: true
name: NOS3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4846
constant: false
type: Species
is: A0S0A7

metaM adrn e
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
boundary condition: false
is: HMDB02226
name: adrenic acid
is: CHEBI:53487

http://identifiers.org/biomodels.db/MODEL1310110031#_4bca6170_0459_4ccb_8e9d_b81b4206f436
is: P54819
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:204
name: AK2

metaM pheme c
is: CHEBI:17627
is: HMDB03178
initial concentration: 1.0
name: Protoheme
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: C00032
boundary condition: false

metaM HC02210 e
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
is: CHEBI:34939
type: Species
name: prostaglandin-d3

metaM xoldioloneh c
constant: false
is: CHEBI:2288
type: Species
is: SBO:0000247
is: HMDB06887
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM ksi deg12 l
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 12
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C174H279N12O153S9 CHARGE: -9

metaM for c
is: HMDB00142
name: Formate
type: Species
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
is: CHEBI:15740
has only substance units: false
is: C00058
boundary condition: false
constant: false
initial amount: NaN

metaR r0208
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.4.1.1
reversible: true
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110031#
type: Reaction

metaM pi c
is: CHEBI:43474
type: Species
constant: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
is: HMDB00973
is: C00009
boundary condition: false
name: hydrogenphosphate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR DCMPDA
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
name: dCMP deaminase
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reversible: true
product: MODEL1310110031#
is described by: ECO:0000254

metaR FUMSO4tm
reversible: true
kinetic law: MODEL1310110031#
fast: false
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
name: Fumarate:sulfate antiport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110031#_401f8a92_349e_4c36_a961_deb39bf8a914
has only substance units: false
name: SLC22A2
boundary condition: true
type: Species
is: SBO:0000252
is: O15244
constant: false
initial concentration: NaN
is encoded by: hsa:6582
initial amount: NaN

metaM formcoa c
is: SBO:0000247
name: formyl-CoA(4-)
initial amount: NaN
is: CHEBI:57376
boundary condition: false
type: Species
is: HMDB03419
constant: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
initial concentration: 1.0

metaR CHOLESTle
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
name: hydrolysis of cholesterol ester by cholesterol esterase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.13
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110031#

metaM HC01415 m
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:27537
constant: false
name: (2E)-Octenoyl-CoA
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial amount: NaN

metaM hexe3coa m
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522
name: 3-hexenoylcoa

metaM ivcoa m
constant: false
is: CHEBI:57345
is: HMDB01113
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: Isovaleryl-CoA
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f011b9e3_4106_4236_8220_e835b7ba4168
constant: false
is: O60547
type: Species
name: GMDS
has only substance units: false
is encoded by: hsa:2762
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0750
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
reversible: true

metaM c81coa c
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: HMDB03949
is: C05276
name: octenoylcoa
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR S6TASE20ly
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false

metaR FAOXC7C5m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM HC01408 m
has only substance units: false
boundary condition: false
is: CHEBI:27648
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
name: 3-Oxohexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110031#_bea73840_fce5_4912_ba11_6a3103244c88
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: NSDHL
boundary condition: true
is encoded by: hsa:50814
is: Q15738

metaM 2dr1p c
is: HMDB01351
constant: false
boundary condition: false
is: CHEBI:58576
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
is: C00672
has only substance units: false
is: SBO:0000247
type: Species
name: 2-Deoxy-D-ribose 1-phosphate

metaR C40CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM C02470 c
has only substance units: false
boundary condition: false
is: HMDB00881
is: C02470
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
name: Xanthurenic acid
is: SBO:0000247
initial concentration: 1.0

metaR CYTK6n
fast: false
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110031#
name: cytidylate kinase (CMP,CTP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaR r0892
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaM pheme e
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
boundary condition: false
name: Protoheme
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00032
is: CHEBI:17627
is: HMDB03178
has only substance units: false

metaM tag hs c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
name: triglyceride
is: CHEBI:17855
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_f7bbe5d2_ea07_4cb5_8fd7_7dcb3d5cd89a
initial concentration: NaN
name: ENTPD1
is encoded by: hsa:953
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q86VV3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_fdd077a9_bce9_4ff9_ad0a_e2963bc6f425
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:389015
name: SLC9A4
constant: false
is: SBO:0000252
type: Species
is: Q6AI14

metaR PPNCL3
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphopantothenate-cysteine ligase
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269

metaR RE2426C
name: RE2426
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:

metaR SBCOAACOTx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_98a6a9f0_d9c0_495a_87d3_2fd3d40369d1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DCK
constant: false
boundary condition: true
is: P27707
is encoded by: hsa:1633
type: Species

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110031#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
product: MODEL1310110031#

metaR r2001
fast: false
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110031#_8142ae6e_aeb2_48b9_a25a_18c1d460f038
initial concentration: NaN
boundary condition: true
name: NDUFA4L2
is: Q9NRX3
is encoded by: hsa:56901
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_aa4e435f_f93a_4c82_8683_d7a300e47433
has only substance units: false
boundary condition: true
name: DHFR
initial concentration: NaN
constant: false
is encoded by: hsa:1719
is: P00374
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_e64be1a0_1f16_415d_a2a7_3f826fa353e0
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: _AI539321_1_c
is: SBO:0000252
is encoded by: hsa:AI539321
constant: false
initial concentration: NaN

metaR S6TASE23ly
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110031#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR AKGMALtm
is described by: ECO:0000269
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
name: alpha-ketoglutarate/malate transporter

metaR P4508B13r
modifier: MODEL1310110031#
name: sterol 12-alpha-hydroxylase (nadh)
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is version of: http://identifiers.org/ec-code/1.14.13.95

metaR RE3627M
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: RE3627
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: true

metaM 5fthf m
is: HMDB01562
initial amount: NaN
is: SBO:0000247
constant: false
name: 5-formyltetrahydrofolate(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
type: Species
is: CHEBI:57457

metaR r0523
product: MODEL1310110031#
reactant: MODEL1310110031#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:

metaM prostgi2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
constant: false
is: CHEBI:57403
name: prostaglandin I2(1-)
type: Species
is: HMDB01335
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e449b1fc_407d_44be_b310_e9ca2bd19bd0
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: O43272
initial amount: NaN
initial concentration: NaN
name: PRODH
is encoded by: hsa:5625
constant: false

metaR RE3347C
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction
name: RE3347
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:

metaM tag hs e
initial concentration: 1.0
is: CHEBI:17855
initial amount: NaN
name: triglyceride
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
boundary condition: false

metaM cmp c
is: HMDB00095
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
boundary condition: false
has only substance units: false
constant: false
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
name: CMP
type: Species

metaM co2 c
name: CO2
initial amount: NaN
initial concentration: 1.0
is: C00011
is: CHEBI:3313
boundary condition: false
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0
constant: false
is: HMDB01967
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_3b234435_4bbb_42ee_a548_a7a32377d934
constant: false
has only substance units: false
is: Q8WWX8
is: SBO:0000252
name: SLC5A11
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:115584
boundary condition: true

metaR r2003
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM prgnlones c
is: HMDB00774
type: Species
constant: false
name: pregnenolone sulfate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
is: CHEBI:35420

metaR FAOXC103C102x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_d9dcdc0f_c438_4862_9284_5001d8c5b080
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q8NFW8
name: CMAS
is encoded by: hsa:55907
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_3be8e55d_c841_4be1_b804_c6a25d46f4bb
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AI971036_1_x
is encoded by: hsa:AI971036
initial amount: NaN

metaR HEXDIACTD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f1101200_8f98_43e7_b2dd_0c5ffb1abaa2
is encoded by: hsa:55902
is: SBO:0000252
initial amount: NaN
type: Species
name: ACSS2
is: Q5QPH3
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5b61ace0_9819_4182_bbc7_06310a2f19d4
is: SBO:0000252
is encoded by: hsa:23236
initial amount: NaN
boundary condition: true
type: Species
name: PLCB1
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f7c14834_1b7b_4d4e_90db_8845ac12a5d7
type: Species
boundary condition: true
name: PPA2
constant: false
has only substance units: false
is encoded by: hsa:27068
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR ALATHRNaEx
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
reversible: false
fast: false
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110031#
is described by: ECO:0000269

metaR NADHtpu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
name: NADH transporter, peroxisome
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
type: Reaction

metaM for m
type: Species
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
boundary condition: false
name: formate
is: CHEBI:15740
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaM co2 e
is: HMDB01967
has only substance units: false
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: CHEBI:16526
initial amount: NaN
is: C00011
initial concentration: 1.0
name: CO2
is: SBO:0000247
boundary condition: false

metaM cmp e
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
is: SBO:0000247
boundary condition: false

metaR PNTEH
is: SBO:0000176
reversible: false
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
type: Reaction
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.1.92
is described by: ECO:0000269
name: Hydrolase Class ( RXN R02973)

metaM b2coa m
is: HMDB02009
boundary condition: false
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
type: Species
initial concentration: 1.0
name: crotonoyl-CoA(4-)
is: CHEBI:57332
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR CYSTHRNaEx
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
fast: false
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

http://identifiers.org/biomodels.db/MODEL1310110031#_4b39dea9_34dd_424c_9990_8575090b7503
type: Species
is: O60312
is: SBO:0000252
is encoded by: hsa:57194
constant: false
name: ATP10A
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaM cl c
is: SBO:0000247
constant: false
initial amount: NaN
is: C00115
is: HMDB00492
type: Species
has only substance units: false
name: Chloride
initial concentration: 1.0
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
boundary condition: false

metaR KSIt
type: Reaction
kinetic law: MODEL1310110031#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
name: keratan sulfate I transport, golgi to extracellular
is: SBO:0000185
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_ebfb5f83_29a8_4b52_a82a_79b4de48f73c
is: SBO:0000252
name: GCNT1
initial amount: NaN
is encoded by: hsa:2650
type: Species
is: Q02742
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5099144f_2363_4d36_92ae_454ddda801ff
is: SBO:0000252
name: HAS3
boundary condition: true
type: Species
constant: false
is: Q96RV2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:3038

http://identifiers.org/biomodels.db/MODEL1310110031#_48f4904d_8126_4f40_83df_bf6cd11f0154
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC24A4
has only substance units: false
is encoded by: hsa:123041
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2487ff1b_3fcf_4714_9ead_7181b4b2c0a4
has only substance units: false
is: Q96BD0
boundary condition: true
name: SLCO4A1
constant: false
initial concentration: NaN
is encoded by: hsa:28231
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_b9963dc3_760f_4de7_bef0_5e8b0a426788
is: Q92781
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: RDH5
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5959

metaR C120CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaM ksii core2 deg7 l
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C44H73N4O30X CHARGE: 0
constant: false
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 7
type: Species
is: HMDB01354
is: CHEBI:57455

metaR LEUTA
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: leucine transaminase

metaM ivcoa c
has only substance units: false
is: HMDB01113
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
name: Isovaleryl-CoA
boundary condition: false

metaR FOAXC122C101x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1dfdcc60_8b97_4904_b98e_249137d492ca
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:3420
name: IDH3A:IDH3B:IDH3G
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1078
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000000
name: Vesicular transport
kinetic law: MODEL1310110031#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110031#

metaM CE1939 e
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: spermidine monoaldehyde 1
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:36781

http://identifiers.org/biomodels.db/MODEL1310110031#_3ff0e5d9_646e_48e7_bc38_4279d995780e
is encoded by: hsa:4723
name: NDUFV1
is: SBO:0000252
boundary condition: true
type: Species
is: E5KNH5
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM CE0785 m
initial concentration: 1.0
constant: false
is: CHEBI:57795
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
has only substance units: false
is: SBO:0000247
name: cis,cis-myristo-5,8-dienoyl-CoA

metaM aacoa c
is: C00332
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286
has only substance units: false
name: Acetoacetyl-CoA
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4e257d51_17ea_4c27_925e_4a4b6adbc581
is encoded by: hsa:6391
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: SDHC
is: SBO:0000252
is: Q99643
has only substance units: false
initial concentration: NaN

metaM cmp g
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247
name: CMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_80579359_bf9d_4d0c_9098_fd98e4f8178d
constant: false
initial concentration: NaN
has only substance units: false
is: Q9BVG9
is: SBO:0000252
boundary condition: true
name: PTDSS2
is encoded by: hsa:81490
initial amount: NaN
type: Species

metaR SPODMx
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
name: superoxide dismutase, peroxisome
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110031#_fe1aea9b_ab07_4752_88eb_821d710cf3dd
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:9107
has only substance units: false
constant: false
name: MTMR6
initial concentration: NaN
is: Q9Y217
type: Species

metaM 5dpmev c
boundary condition: false
initial amount: NaN
is: HMDB01090
has only substance units: false
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
type: Species

metaR RE2759X
is version of: http://identifiers.org/ec-code/5.1.99.4
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
name: RE2759
modifier: MODEL1310110031#
product: MODEL1310110031#

metaM c4crn e
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
is: HMDB02013
is: C02862
name: butyryl carnitine
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
is: SBO:0000247

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaM ptth c
initial concentration: 1.0
is: SBO:0000247
name: pantetheine
is: HMDB03426
boundary condition: false
constant: false
is: CHEBI:16753
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
type: Species

metaM trdrd c
type: Species
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00342
is: CHEBI:15967
has only substance units: false
constant: false
name: Reduced thioredoxin

metaR Htx
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110031#
reversible: true
fast: false
name: H transporter, peroxisome
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_b5010259_b2ba_462c_b504_fc47094409ee
is: Q5MY95
has only substance units: false
is encoded by: hsa:377841
initial concentration: NaN
name: ENTPD8
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM ksi deg11 l
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 11
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: HMDB00143
type: Species
boundary condition: false
constant: false
is: CHEBI:12936

metaM urcan c
name: Urocanate
type: Species
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: SBO:0000247
boundary condition: false
is: C00785
constant: false
initial amount: NaN
is: CHEBI:17771
is: HMDB00301
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_42fd6319_3665_41dd_b52c_ceb0fe358b69
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2194
has only substance units: false
name: FASN
type: Species
is: P49327

metaM strdnccoa x
constant: false
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205473
is: HMDB06519
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: stearidonyl coenzyme A

metaM HC00695 m
name: S-Succinyldihydrolipoamide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
is: SBO:0000247
is: CHEBI:17432
initial amount: NaN
boundary condition: false
type: Species

metaM glutcoa c
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
has only substance units: false
is: HMDB01339
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: glutaryl-CoA(5-)
constant: false
is: SBO:0000247

metaM m3mpdol L c
type: Species
initial concentration: 1.0
is: CHEBI:37632
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog
has only substance units: false
constant: false
is: SBO:0000247

metaR ATP2ter
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_f0445954_1853_4827_bb7f_aff28ee12fe8
type: Species
initial amount: NaN
initial concentration: NaN
is: Q9GZS9
constant: false
is: SBO:0000252
name: CHST5
has only substance units: false
is encoded by: hsa:23563
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_91376a07_59fa_47ee_bbfe_854f052f0a4d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:57468
boundary condition: true
constant: false
name: SLC12A5
is: Q9H2X9

http://identifiers.org/biomodels.db/MODEL1310110031#_042756c8_2b24_4830_aa72_bfcf08aa01b5
boundary condition: true
is encoded by: hsa:6482
name: ST3GAL1
is: Q11201
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_a36b5b7d_f6d9_42b1_9216_37707a01f014
constant: false
name: INPP5D
type: Species
is: Q92835
has only substance units: false
initial amount: NaN
is encoded by: hsa:3635
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_100f93bd_73be_4d05_af45_b1ec497eced0
boundary condition: true
is: P15289
type: Species
is: SBO:0000252
is encoded by: hsa:410
name: ARSA
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6a005002_7cd3_470e_8ed6_02bd331075d1
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:10637
is: SBO:0000252
initial amount: NaN
is: O75610
name: LEFTY1

metaR r2379
fast: false
is: SBO:0000185
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

metaM ddece1crn e
name: dodecenoyl carnitine
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02250
notes: FORMULA: C19H35NO4 CHARGE: 0
constant: false

metaM c4crn c
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
is: C02862
boundary condition: false
name: butyryl carnitine
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_93fd383a_4a4b_47ea_a51c_4da91b65de89
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5337
name: PLD1
is: Q59EA4
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR DOLPGT1 Ler
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
fast: false
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
kinetic law: MODEL1310110031#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.267
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_12dc7339_b2e1_46b9_b60c_b4269806452e
is encoded by: hsa:51
initial concentration: NaN
is: B4DK61
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: ACOX1
has only substance units: false

metaR UDPGLCAter
type: Reaction
modifier: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false

metaR DMHPTCRNte
name: 2,6 dimethylheptanoyl carnitine transport
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false

metaM octd11ecoa m
name: 11-octadecenoylcoa
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06294
initial concentration: 1.0

metaR EX c10crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_e7f7b929_e3da_40f2_9cba_361e62c5a328
initial amount: NaN
type: Species
boundary condition: true
name: TXNRD2
is encoded by: hsa:10587
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR NACHEX22ly
product: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000

metaM tridcoa m
initial concentration: 1.0
is: HMDB13109
name: tridecanoylcoa
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C34H56N7O17P3S CHARGE: -4

metaM CE5854 e
type: Species
initial amount: NaN
is: CHEBI:27485
boundary condition: false
name: gama-CEHC-glucuronide
is: SBO:0000247
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
has only substance units: false
is: HMDB02710
constant: false

metaM 5htrp c
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
constant: false
is: HMDB00472
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR Htr
is described by: ECO:0000000
type: Reaction
reversible: true
name: H transporter, endoplasmic reticulum
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110031#
fast: false

metaR PI45P4P
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
reversible: false
type: Reaction

metaM HC00664 c
is: SBO:0000247
is: CHEBI:58695
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: D-tagatofuranose 6-phosphate(2-)
has only substance units: false

metaM CE2838 e
boundary condition: false
name: maltononaose
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
type: Species
constant: false
is: SBO:0000247

metaR G14T19g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM c16dc e
is: SBO:0000247
initial concentration: 1.0
name: Hexadecanedioic acid mono-L-carnitine ester
is: HMDB00712
type: Species
constant: false
notes: FORMULA: C23H42NO6 CHARGE: -1
boundary condition: false
has only substance units: false
initial amount: NaN

metaM apoC Lys btn c
initial concentration: 1.0
type: Species
is: CHEBI:32551
is: SBO:0000247
constant: false
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial amount: NaN
boundary condition: false
is: HMDB00182
notes: FORMULA: C16H27N4O3SX CHARGE: 0

metaR TRIOK
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: triokinase
fast: false
type: Reaction
product: MODEL1310110031#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_99c97946_31e9_4314_a242_dfc6fb428ffb
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3420
initial concentration: NaN
type: Species
is: O43837
name: IDH3B
is: SBO:0000252
initial amount: NaN

metaR DDECE1CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM ksii core2 deg1 l
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57737
has only substance units: false
is: HMDB00868
name: keratan sulfate II (core 2-linked), degradation product 1
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C70H113N5O59S3X CHARGE: -3

metaR GMAND
fast: false
is described by: ECO:0000000
name: GDP-D-mannose dehydratase
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
is version of: http://identifiers.org/ec-code/4.2.1.47

metaR GALASE14ly
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110031#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR r0317
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction

metaR DOLPMT3 Uer
product: MODEL1310110031#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: false
fast: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_97486759_f6da_446f_8ec3_5731bf545e59
name: ALDH1A3
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:220
initial amount: NaN
type: Species
is: P47895
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_3c9e28f7_5f02_43b2_b2be_ff320aa3a032
name: _AI971036_1_m
is encoded by: hsa:AI971036
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM c6dc c
boundary condition: false
has only substance units: false
name: adipoyl carnitine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00705
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR S3TASE2ly
reversible: true
reactant: MODEL1310110031#
type: Reaction
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-3-sulfatase, lysosomal

metaR A MANASEly
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.24
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
name: alpha-mannosidase, lysosomal

metaR PIACGT
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.198
name: phosphatidylinositol N-acetylglucosaminyltransferase
modifier: MODEL1310110031#
reversible: false
fast: false

metaM ksi pre10 g
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 10
type: Species
has only substance units: false
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: C00130
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM cl e
initial concentration: 1.0
initial amount: NaN
name: Chloride
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
type: Species
constant: false
is: SBO:0000247
is: CHEBI:3966
boundary condition: false
is: C00115

metaR It
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
name: Iodide uniport
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
modifier: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_41829fb9_3528_41ed_837f_1a8763f9304d
is encoded by: hsa:5092
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: PCBD1

metaM ddece1crn c
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB03712
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
name: dodecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110031#_6d06558d_6b0c_41c2_9c95_33b6623ed943
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is: SBO:0000176
reversible: true
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#

metaM pail345p hs c
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57836
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_d5b7efb3_ed33_4d14_8522_c6e4fade5507
has only substance units: false
is encoded by: hsa:3418
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: IDH2
is: P48735

metaM hexde7coa x
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
name: 7-hexadecenoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM doldp L r
constant: false
is: SBO:0000247
name: Dolichol diphosphate, human liver homolog
type: Species
is: CHEBI:15750
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
has only substance units: false

metaM 3mox4hoxm c
is: CHEBI:27622
boundary condition: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
initial amount: NaN
is: HMDB00291
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: 3-Methoxy-4-hydroxymandelate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_9a7ada88_7267_40c4_9af4_48fc8204f494
initial amount: NaN
is: B7Z7I0
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: TKTL1
initial concentration: NaN
is encoded by: hsa:8277

metaM od2coa c
has only substance units: false
type: Species
name: trans-Octadec-2-enoyl-CoA
is: C16218
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:50570
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: HMDB06529
initial amount: NaN

metaM c16dc c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H42NO6 CHARGE: -1
constant: false
has only substance units: false
boundary condition: false
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247
type: Species

metaR AKR1D2
is: SBO:0000176
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_82789276_cc7f_406f_b5ce_42388bdda8aa
is: SBO:0000252
type: Species
has only substance units: false
name: _U37519_1_c
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:U37519
initial amount: NaN

metaR RE0577C
modifier: MODEL1310110031#
reversible: true
fast: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110031#
name: RE0577
is version of: http://identifiers.org/ec-code/3.1.2.2

metaM crvnc e
type: Species
initial amount: NaN
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
is: CHEBI:36005
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02183

metaM od2coa m
is: HMDB06529
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: trans-Octadec-2-enoyl-CoA
is: CHEBI:50570
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
type: Species

metaM 2dp6mobq me m
has only substance units: false
is: CHEBI:50772
boundary condition: false
type: Species
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
initial concentration: 1.0
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_123a02d1_0ede_40b9_82fc_3c6930db9f90
boundary condition: true
is encoded by: hsa:518
is: SBO:0000252
name: ATP5G3
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: P48201
type: Species

metaR CYSSERNaEx
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
modifier: MODEL1310110031#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110031#
reversible: false
type: Reaction
is: SBO:0000185

metaM lac L c
initial concentration: 1.0
name: (S)-lactate
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: HMDB00190

metaR r2376
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_8ea48ade_c62f_48b9_9d5c_df471e952b41
initial concentration: NaN
is encoded by: hsa:AA177072
initial amount: NaN
name: _AA177072_1_c
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR NADPtxu
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
reactant: MODEL1310110031#
is: SBO:0000185
reversible: false
type: Reaction
name: NADP transporter, peroxisome

metaR PRAGSr
modifier: MODEL1310110031#
type: Reaction
name: phosphoribosylglycinamide synthase
is: SBO:0000176
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
reversible: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
name: Dolichol-phosphate phosphohydrolase, human (liver)

http://identifiers.org/biomodels.db/MODEL1310110031#_09b92527_ef66_4341_bff4_caa00bfd35ec
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: Q9BZV2
is encoded by: hsa:80704
initial concentration: NaN
name: SLC19A3
type: Species

metaR ADRNt
reversible: true
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR ABO7g
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110031#
fast: false

metaM 3mop e
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
type: Species
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaM strdnccoa c
has only substance units: false
is: HMDB06519
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
is: C16163
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
name: stearidonyl coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_618d235c_629f_47bc_a9ad_c1a4c50751a0
initial concentration: NaN
is: P09917
is: SBO:0000252
is encoded by: hsa:240
has only substance units: false
initial amount: NaN
boundary condition: true
name: ALOX5
type: Species
constant: false

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
type: Species
is: CHEBI:58216
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r2375
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR ACCOAtn
name: acetyl-CoA transport, nuclear
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_7d1756f5_5b0c_412c_ade5_2d62b2e1897e
is encoded by: hsa:2977
is: SBO:0000252
is: P33402
initial concentration: NaN
initial amount: NaN
name: GUCY1A2
boundary condition: true
type: Species
constant: false
has only substance units: false

metaM 34dhpac c
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: HMDB03791
is: SBO:0000247
type: Species

metaM c12dc c
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
constant: false
is: HMDB00623
initial concentration: 1.0
name: dodecanedioyl carnitine
has only substance units: false

metaM co2 m
has only substance units: false
is: CHEBI:16526
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: C00011
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: SBO:0000247

metaM cmp m
is: HMDB00095
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: CHEBI:60377
is: SBO:0000247

metaR r0630
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
kinetic law: MODEL1310110031#
type: Reaction

metaM lnlccoa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
constant: false
type: Species
is: HMDB01064
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
name: linoleic coenzyme A
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_558e33c4_0f31_4192_9a59_3d85bbde10bd
is encoded by: hsa:594
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: BCKDHB
is: P21953
constant: false
has only substance units: false

metaM 3decdicoa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
name: 3,7-decadienoylcoa
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
constant: false
is: SBO:0000247

metaR S6T7g
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110031#
type: Reaction
reversible: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000

metaR r2378
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110031#_7af4ce0a_3c7f_49f4_9d21_7d1089228375
boundary condition: true
has only substance units: false
constant: false
name: HMGCL
is encoded by: hsa:3155
type: Species
is: Q6IBC0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM dece4coa x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 4-decenoylcoa
constant: false
type: Species
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02145

metaR G14T18g
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
modifier: MODEL1310110031#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
fast: false

metaR ALCD21 D
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (D-1,2-propanediol)

metaM dhf m
is: HMDB01056
initial concentration: 1.0
has only substance units: false
is: CHEBI:57451
boundary condition: false
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
initial amount: NaN
name: dihydrofolate(2-)
is: SBO:0000247

metaR CITtam
type: Reaction
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000269
reversible: true
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_0e07cc25_5bbf_41f1_8afa_b1a364b83300
is encoded by: hsa:11001
name: SLC27A2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: O14975
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_4cf2a320_d1fa_42cb_9749_74e0330edeba
constant: false
is: SBO:0000252
boundary condition: true
name: B3GNT1
initial concentration: NaN
initial amount: NaN
is: O43505
is encoded by: hsa:11041
type: Species
has only substance units: false

metaR PROSTGF2t
product: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
name: prostaglandin uniport
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
type: Reaction

metaR r0633
reversible: true
fast: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.7.3
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM lac L e
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16651
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
initial amount: NaN
name: (S)-lactate
is: SBO:0000247
is: HMDB00190

metaM ptdcacrn c
name: pendtadenoyl carnitine
is: CHEBI:18303
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM cmp n
type: Species
name: CMP(2-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
has only substance units: false
initial amount: NaN
constant: false

metaM cs a deg2 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15748
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110031#_72d0b30a_7de9_4ed2_946b_d1514d43ee86
is: Q16851
has only substance units: false
name: UGP2
is encoded by: hsa:7360
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaR PI345P5P
kinetic law: MODEL1310110031#
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD

metaM 2mop m
initial concentration: 1.0
is: HMDB01172
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
name: 2-methyl-3-oxopropanoate
has only substance units: false
boundary condition: false
is: CHEBI:57700

metaM c6dc x
name: adipoyl carnitine
notes: FORMULA: C13H22NO6 CHARGE: -1
is: C14143
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB04047

metaR r2377
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_157025e2_1d3f_4b55_85a4_46940ba62d08
is: SBO:0000252
is encoded by: hsa:6550
boundary condition: true
name: SLC9A3
constant: false
is: P48764
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaM 3mop c
is: HMDB00491
type: Species
has only substance units: false
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
name: 3-methyl-2-oxopentanoate
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM HC00591 c
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
constant: false

metaM xan c
is: SBO:0000247
is: CHEBI:17712
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Xanthine
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
type: Species
is: HMDB00292
constant: false
is: C00385
has only substance units: false

metaM tchola e
name: taurocholic acid
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00036
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f93daab8_a956_4df5_b4ff_fbd342ae17db
is: SBO:0000252
initial amount: NaN
name: SLC6A14
constant: false
is: Q9UN76
is encoded by: hsa:11254
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

metaM arachcrn m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: arachidyl carnitine
constant: false
has only substance units: false
type: Species
is: HMDB06460
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

http://identifiers.org/biomodels.db/MODEL1310110031#_a03f43f7_e979_42a5_90aa_dbbc9cd13150
name: OGDHL
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9ULD0
is encoded by: hsa:55753
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e9e8d39b_12aa_4590_986e_cbab2bfde031
is: SBO:0000297
is encoded by: hsa:594
has only substance units: false
boundary condition: true
type: Species
name: DBT:DLD:BCKDHA:BCKDHB
constant: false
initial amount: NaN
initial concentration: NaN
has part: Q9BQL0

metaM ksi deg28 l
type: Species
is: CHEBI:57455
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 28
is: HMDB01354

metaM cs b deg1 l
has only substance units: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
type: Species
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01354
boundary condition: false

metaM arachdcoa m
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
is: HMDB06523
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57368
type: Species

metaR DGULND
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
name: dehydro-L-gulonate decarboxylase
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM decdicrn c
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
boundary condition: false
is: HMDB13325
initial amount: NaN

metaM aacoa x
is: SBO:0000247
initial amount: NaN
is: CHEBI:57286
initial concentration: 1.0
constant: false
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
boundary condition: false
is: HMDB01484
type: Species

metaR RE2660C
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
name: RE2660
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110031#
fast: false

metaM octd11ecoa c
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280771

metaR r2372
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR ALAt4
is: SBO:0000185
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
name: Alanine-Sodium symporter
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.

http://identifiers.org/biomodels.db/MODEL1310110031#_3c26d1ae_f0f3_43fa_abf7_b1602df9c6fd
initial concentration: NaN
has part: P00325
name: ADH1A:ADH1B
type: Species
is: SBO:0000297
has only substance units: false
is encoded by: hsa:124
has part: P07327
is encoded by: hsa:125
boundary condition: true
initial amount: NaN
constant: false

metaR RTOTALt
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185
name: RTOTAL transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0a3185e1_c7fd_40a6_9bc8_3d9427badc94
name: SLC25A26
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:115286
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q70HW3

http://identifiers.org/biomodels.db/MODEL1310110031#_5bc02b8c_43c1_4ba9_9941_8784db9a5bc2
is: SBO:0000252
initial concentration: NaN
is: D6RDW3
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2982
name: GUCY1A3
has only substance units: false
type: Species

metaR r0634
is described by: ECO:0000000
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176

metaR r0747
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true

metaM anth c
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16567
boundary condition: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM tchola c
name: taurocholic acid
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:36257
is: HMDB00036
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
boundary condition: false

metaR r2371
reactant: MODEL1310110031#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#

metaM sphmyln hs g
is: CHEBI:58216
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
has only substance units: false
boundary condition: false
name: sphingomyelin betaine
is: SBO:0000247

metaR LPS3e
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
modifier: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
reversible: false
fast: false
reactant: MODEL1310110031#
name: lipase, extracellular

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction

metaM co2 r
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01967
name: CO2
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
constant: false
is: CHEBI:16526

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM glu5sa m
type: Species
constant: false
is: C01165
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02104
name: L-Glutamate 5-semialdehyde
is: SBO:0000247
boundary condition: false

metaM decdicrn e
name: decadienoyl carnitine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB13325
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C17H29NO4 CHARGE: 0

metaR G13MT U
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.132
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000

metaR DNDPt30m
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
name: dCDP transport via ADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false

metaM 3dodtricoa x
name: 3,6,9-dodecatrienoylcoa
is: C05279
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR r1298
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Vesicular transport
type: Reaction
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_5062a9b0_b308_40ed_a319_7b1041edc1fb
name: PDE9A
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152

metaR r0423
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110031#
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_0ff4c893_0490_4819_b1d7_e4fb6d81bfb3
type: Species
name: TXNRD2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10587
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_30b01973_afbe_41e3_8007_01829424d5dd
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PLCE1
is encoded by: hsa:51196
type: Species
constant: false
is: Q9P212
has only substance units: false

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR r2374
is described by: ECO:0000000
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110031#
type: Reaction
fast: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_3f6eb867_757c_4157_ac69_0f1c52890aa4
initial amount: NaN
has only substance units: false
constant: false
name: FUK
is encoded by: hsa:197258
is: Q8N0W3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR TPI
name: triose-phosphate isomerase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_59a0deb3_4c71_45e7_9481_31f661abb0a4
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:113235
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC46A1
is: Q96NT5

metaR RE3050R
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110031#
name: RE3050
reactant: MODEL1310110031#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_5b3b9617_c5d0_4580_86a4_296a92ae9ad6
initial concentration: NaN
has only substance units: false
name: PC
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5091

metaR GGT6
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
reversible: true
name: Gamma-glutamyltransferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110031#

metaR GALt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110031#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
name: galactose transport via sodium symport
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_1aea84ca_89cc_406c_83c5_70f284880376
name: SDHD
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6392
boundary condition: true
type: Species
is: O14521

metaR LNSTLSr
modifier: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
name: lanosterol synthase
fast: false
is version of: http://identifiers.org/ec-code/5.4.99.7
kinetic law: MODEL1310110031#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_e6d730fe_d06b_452e_9cec_2037e48d3407
is encoded by: hsa:4718
initial concentration: NaN
name: NDUFC2
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: Q549M5

metaR r1299
is: SBO:0000185
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Vesicular transport

metaR r0422
product: MODEL1310110031#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110031#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

metaM pyam5p c
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Pyridoxamine 5'-phosphate
type: Species
is: C00647
is: HMDB01555
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58451
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c30fc447_8509_4b54_9a71_cb80fc87c6d2
is encoded by: hsa:2879
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: P36969
initial concentration: NaN
name: GPX4
is: SBO:0000252
constant: false

metaM 3mgcoa m
is: CHEBI:57346
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR RETH
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
product: MODEL1310110031#
name: retinyl ester hydrolase
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_65dce99d_8823_4afc_b8d8_fba42611269b
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: _AI373818_1_m
is encoded by: hsa:AI373818
constant: false

metaR D LACt2
kinetic law: MODEL1310110031#
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
modifier: MODEL1310110031#
name: D-lactate transport via proton symport
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110031#

metaM anth e
is: HMDB01123
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
name: anthranilate
type: Species
is: CHEBI:16567
has only substance units: false

metaM gdpfuc g
is: CHEBI:57984
is: HMDB01095
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR r0321
reversible: false
type: Reaction
is: SBO:0000176
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.3.5.2
is described by: ECO:0000000
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#

metaR r2373
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
product: MODEL1310110031#

metaR ACGAMK
is version of: http://identifiers.org/ec-code/2.7.1.59
name: N-acetylglucosamine kinase
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR GTHO
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
fast: false
type: Reaction
name: glutathione oxidoreductase

metaM m6mpdol L r
is: CHEBI:37635
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR UGALNACtg
reversible: true
type: Reaction
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

metaM xu5p D c
has only substance units: false
is: CHEBI:57737
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
name: D-xylulose 5-phosphate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00868
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4946b806_fd58_468f_b95b_9b836fdc130c
has only substance units: false
is: SBO:0000252
name: ATP2B4
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:493
constant: false
is: P23634

metaR r0744
reversible: false
product: MODEL1310110031#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaR KAS8
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110031#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction

metaR r0885
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185

metaM ptdcacrn m
is: SBO:0000247
name: pendtadenoyl carnitine
boundary condition: false
type: Species
is: CHEBI:18303
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110031#_2262fb2e_faa6_4cad_804d_7a2ec62da765
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PROSC
type: Species
has only substance units: false
is: O94903
is encoded by: hsa:11212

metaR r2005
reversible: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e0e43420_3850_4d8d_a699_217c14ea508a
is: SBO:0000252
is: B4DYG5
boundary condition: true
has only substance units: false
constant: false
name: PI4KA
initial concentration: NaN
is encoded by: hsa:5297
initial amount: NaN
type: Species

metaR r0638
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_c2441877_1d89_409c_b287_4b4831e4c946
is: Q9NUD9
constant: false
type: Species
boundary condition: true
name: PIGV
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:55650

metaR FAOXC101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_ccc11ada_c26a_4596_99e1_db03c9a306af
boundary condition: true
constant: false
is encoded by: hsa:3420
has only substance units: false
is: SBO:0000252
name: IDH3B
type: Species
initial amount: NaN
initial concentration: NaN

metaR r0743
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
reactant: MODEL1310110031#

metaM lnlccoa m
is: HMDB01064
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A

metaM 3hpp m
is: CHEBI:16510
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
name: 3-hydroxypropionate
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00700
initial concentration: 1.0
type: Species

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110031#

metaR FALDH
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
name: formaldehyde dehydrogenase
product: MODEL1310110031#

metaM 3mop m
has only substance units: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: SBO:0000247
is: CHEBI:28654

http://identifiers.org/biomodels.db/MODEL1310110031#_071ee694_406a_48a3_8fd6_73e5c7dd412f
initial amount: NaN
is: B4DR31
is encoded by: hsa:1808
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: DPYSL2

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_dbfc219f_9cde_48af_baa7_5719a8ce492e
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: SDHA
initial amount: NaN
is: P31040
is encoded by: hsa:6389

metaM g6p c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
is: C00092
is: CHEBI:61548
name: D-Glucose 6-phosphate
constant: false
type: Species
is: HMDB01401
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_06e1762d_5026_4f2c_b291_795164596def
initial concentration: NaN
constant: false
name: ACAD9
is encoded by: hsa:28976
boundary condition: true
initial amount: NaN
type: Species
is: Q9H845
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_7c88e624_2901_4184_a32d_0c60a8f44790
is: Q8TB61
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC35B2
initial concentration: NaN
is encoded by: hsa:347734
has only substance units: false
type: Species
boundary condition: true

metaM udpglcur r
is: C00167
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:58052
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
name: UDP-D-glucuronate
is: SBO:0000247
is: HMDB00935
constant: false
initial concentration: 1.0
has only substance units: false

metaM apoC Lys c
type: Species
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: Apocarboxylase (Lys residue)
is: HMDB00182
initial concentration: 1.0

metaR 3MOPte
is described by: ECO:0000134
type: Reaction
product: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
name: Transport of 3-methyl-2-oxopentanoate

metaR ADPT
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.2.7
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000269
name: adenine phosphoribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110031#_9b258e72_1db8_4df6_a51c_e612e34d1b47
boundary condition: true
has only substance units: false
is encoded by: hsa:55967
initial amount: NaN
name: NDUFA12
type: Species
is: SBO:0000252
is: F8VQS7
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_de189988_efff_4398_8bc0_d86f2e15e65e
constant: false
is: P05496
initial amount: NaN
is encoded by: hsa:516
is: SBO:0000252
initial concentration: NaN
name: ATP5G1
boundary condition: true
has only substance units: false
type: Species

metaM CE2422 m
is: CHEBI:28387
is: HMDB11123
boundary condition: false
type: Species
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaM q10 m
is: HMDB01072
boundary condition: false
name: ubiquinone-10
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
is: CHEBI:46245

metaR ALCD21 L
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (L-1,2-propanediol)
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1

metaM ddsmsterol r
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: 7-dehydrodesmosterol
is: CHEBI:27910
initial concentration: 1.0
has only substance units: false
is: HMDB03896
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5215b511_6293_44ef_8f49_d4054011cfc6
is encoded by: hsa:4357
has only substance units: false
initial concentration: NaN
is: P25325
type: Species
initial amount: NaN
boundary condition: true
name: MPST
is: SBO:0000252
constant: false

metaM CE5867 e
has only substance units: false
initial concentration: 1.0
constant: false
name: N-acetyl-seryl-aspartyl-lysyl-proline
is: CHEBI:27485
type: Species
is: HMDB02710
initial amount: NaN
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_cc41b11e_c2da_463c_a908_3e09d0d59965
has only substance units: false
initial amount: NaN
is: Q9H6Y6
is encoded by: hsa:4645
initial concentration: NaN
type: Species
name: MYO5B
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_1b968554_8e2b_4600_a1b1_6a25d5df2bb9
is: SBO:0000252
is encoded by: hsa:3632
name: INPP5A
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q14642
initial concentration: NaN

metaR 34DHPLACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
fast: false
is: SBO:0000176
type: Reaction
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#

metaR FAOXC3DC
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_46551ed4_2bf7_4260_8190_b7028dd3ce30
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:728226
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _728226_1_e

metaR S4TASE4ly
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110031#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_636930ef_14df_42ca_8b49_cd67210ba693
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: UGDH
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: O60701
is encoded by: hsa:7358

http://identifiers.org/biomodels.db/MODEL1310110031#_ee334b35_b664_4c87_b5e4_92875be214d6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q9NNW7
name: TXNRD2
is encoded by: hsa:10587

metaM gdpfuc c
is: CHEBI:57984
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01095
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)
type: Species
boundary condition: false

metaR r0531
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
type: Reaction
modifier: MODEL1310110031#

metaR CYTK5n
type: Reaction
reversible: true
reactant: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
name: cytidylate kinase (CMP),nuclear

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1f17fca0_6acc_4fbb_a628_5d2af295868c
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:51477
is: SBO:0000252
is: B3KRT1
has only substance units: false
name: ISYNA1
initial amount: NaN

metaR DNDPt23m
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
name: dTDP transport via dGTP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR PTE4x
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.2
name: peroxisomal acyl-CoA thioesterase
is described by: ECO:0000269
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176

metaM ficytC m
boundary condition: false
constant: false
initial concentration: 1.0
name: Ferricytochrome c
is: CHEBI:15991
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ksi deg23 l
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 23
initial amount: NaN
is: HMDB00143
boundary condition: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: CHEBI:12936

metaR r1292
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
name: Postulated transport reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
type: Reaction

metaM digalside hs c
is: C06126
boundary condition: false
is: http://identifiers.org/pubchem.compound/8383
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
has only substance units: false
initial amount: NaN
name: Digalactosylceramide
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_55f7b55f_65a9_4f3f_871f_d2b70e35f80f
is encoded by: hsa:27068
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: PPA2
is: F8WDN9
boundary condition: true
constant: false
is: SBO:0000252

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaM dece4coa m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB02145
name: 4-decenoylcoa
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_4f1afa1e_475c_4a13_87eb_6b98dc26cc65
boundary condition: true
type: Species
is encoded by: hsa:5091
initial amount: NaN
name: PC
is: P11498
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r2009
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
reversible: false

metaR ACACt2
is: SBO:0000185
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269
reversible: true
name: acetoacetate transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD

metaR LNLNCGCPT2
fast: false
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110031#
name: carnitine transferase
modifier: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#

metaM co2 x
constant: false
type: Species
is: HMDB01967
name: carbon dioxide
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_15960269_7630_46c3_9a79_33762d2030bb
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ARSB
is: SBO:0000252
is: A8K4A0
type: Species
is encoded by: hsa:411
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2579d4af_29db_45f2_9761_a017253c1059
name: NDUFB7
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P17568
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4713

http://identifiers.org/biomodels.db/MODEL1310110031#_777f82a6_07a9_426e_b024_c39835b7a9c1
is: SBO:0000252
type: Species
has only substance units: false
name: _U37519_1_e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:U37519
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_025488b0_64de_43ac_a39e_ca36a2ad59ba
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PDE8B
type: Species
constant: false
is: O95263
is encoded by: hsa:8622

metaR 3HKYNAKGAT
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000304
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
kinetic law: MODEL1310110031#

metaM Sfglutth c
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false
has only substance units: false
is: CHEBI:57688
constant: false
is: SBO:0000247
initial amount: NaN
name: S-formylglutathionate(1-)
is: HMDB01550
type: Species

metaM arachcrn c
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: SBO:0000247
is: HMDB06460
name: arachidyl carnitine

metaR INSTt4
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
name: inositol transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110031#_f25ea14d_dc9a_4b20_a919_9e13645ca273
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q8NFF5
name: FLAD1
constant: false
is: SBO:0000252
is encoded by: hsa:80308
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_9d8cc197_9f96_462d_992c_b8f90ec6c384
initial amount: NaN
is encoded by: hsa:522
is encoded by: hsa:518
is encoded by: hsa:10476
has part: P18859
is: SBO:0000297
is encoded by: hsa:515
boundary condition: true
has part: P24539
has only substance units: false
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
initial concentration: NaN
has part: O75947

metaR DRIBt
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
name: deoxyribose transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
type: Reaction

metaM trdrd m
is: SBO:0000247
type: Species
constant: false
name: Reduced thioredoxin
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false

metaM dhf c
is: C00415
type: Species
is: HMDB01056
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 7,8-Dihydrofolate
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
is: CHEBI:57451
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_f83f90d6_e920_4e32_8ff2_1d92bec96c5c
is encoded by: hsa:1719
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P00374
name: DHFR
type: Species

metaR C101CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM malttr e
is: HMDB01262
is: C01835
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: maltotriose
is: CHEBI:27931
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835

metaR LNLNCGCPT1
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110031#
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#

metaR ADPRDP
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11164.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES:
reactant: MODEL1310110031#
name: ADPribose diphosphatase
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.13
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_29f31dc9_07f9_4b1f_aeca_9e803e709a58
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252
name: PDE8A
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_50d04102_f2be_4da0_9a08_df40d32a362d
constant: false
name: SLC34A2
initial concentration: NaN
has only substance units: false
is: O95436
is encoded by: hsa:10568
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaM hs deg13 l
is: SBO:0000247
name: heparan sulfate, degradation product 13
is: HMDB06210
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM arachdcoa c
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: arachidonoyl-CoA(4-)
constant: false
initial concentration: 1.0
is: HMDB06523
boundary condition: false
is: CHEBI:57368
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaM mescoa m
initial amount: NaN
is: CHEBI:27969
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: Mesaconyl-CoA
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: C06028

metaM formcoa x
has only substance units: false
boundary condition: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
constant: false
type: Species
is: HMDB03419
is: CHEBI:57376
initial amount: NaN
initial concentration: 1.0
name: formyl-CoA(4-)
is: SBO:0000247

metaM aacoa m
constant: false
is: HMDB01484
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57286
has only substance units: false
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
initial concentration: 1.0

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: Ubiquinone biosynthesis methyltransferase COQ5
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:36005
has only substance units: false
is: HMDB02183
initial amount: NaN
initial concentration: 1.0
type: Species
name: cervonic acid, C22:6 n-3

metaR LEUKTRD4t
type: Reaction
kinetic law: MODEL1310110031#
name: leukotriene D4 transport
reactant: MODEL1310110031#
is described by: ECO:0000269
reversible: true
product: MODEL1310110031#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_728155e5_b1cf_4c81_9c33_ef256aab82b4
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI440329
name: _AI440329_1_r
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_eca80eab_1e37_46ce_ab19_7776180ff8de
name: ATP1A4:ATP1B1
constant: false
is encoded by: hsa:480
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000297
has part: Q13733
initial amount: NaN
has only substance units: false

metaR r1291
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110031#
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaR r0741
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#

metaR DOLMANP Lter
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110031#
reversible: false
name: dolichol-phosphate mannose flippase (liver)
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000185

metaR C4CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR SPHS1Pte
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
name: sphingosine-1-phosphate transport

metaM strdnccoa m
name: stearidonyl coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
initial concentration: 1.0
is: HMDB06519
type: Species
boundary condition: false
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
initial amount: NaN

metaR TTDCAFATPc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FUT17g
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.69
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a86d4008_3417_426c_90ae_83be4eec3124
boundary condition: true
has only substance units: false
name: ALDH1A3
is: P47895
is: SBO:0000252
type: Species
is encoded by: hsa:220
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_78f65af8_61c9_41e0_8771_a0a843e4a105
type: Species
name: GART
has only substance units: false
constant: false
is: P22102
initial concentration: NaN
is encoded by: hsa:2618
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RE1516M
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
is: SBO:0000176
name: RE1516
fast: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110031#_8ed4b1e1_e844_4125_a4c3_d96f60f2fb82
has only substance units: false
name: OXCT1
is: SBO:0000252
is: P55809
is encoded by: hsa:5019
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaR RE2660N
modifier: MODEL1310110031#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176
name: RE2660
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
type: Reaction

metaM thcholstoic x
is: CHEBI:18402
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
initial concentration: 1.0
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaR OCDCEAtr
product: MODEL1310110031#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM ppcoa x
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
initial concentration: 1.0
is: SBO:0000247
is: C00100
initial amount: NaN
name: Propanoyl-CoA
type: Species
has only substance units: false
constant: false
boundary condition: false

metaR SUCCOAPET
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM hs deg15 l
has only substance units: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
boundary condition: false
name: heparan sulfate, degradation product 15
initial amount: NaN
is: CHEBI:16126
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaM atp r
constant: false
type: Species
boundary condition: false
is: CHEBI:57299
initial concentration: 1.0
has only substance units: false
is: HMDB00538
is: SBO:0000247
is: C00002
initial amount: NaN
name: ATP(4-)

metaR HTDCACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_89d4e119_4a4b_4c1b_a691_4e3c03b025d3
is: SBO:0000252
name: ALG3
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10195
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_bf04176f_0722_4a40_9bd8_16b475bd556c
initial concentration: NaN
is: P14324
initial amount: NaN
constant: false
name: FDPS
is: SBO:0000252
is encoded by: hsa:2224
boundary condition: true
type: Species
has only substance units: false

metaM glac c
constant: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
boundary condition: false
name: D-glucurono-6,3-lactone
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:18268

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false
is: CHEBI:58343
constant: false
initial concentration: 1.0
type: Species
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_bcafe526_d0cd_4f4c_b32c_5151bba518c6
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3158
is: P54868
initial concentration: NaN
name: HMGCS2
type: Species
constant: false
initial amount: NaN

metaR GALASE4ly
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: beta-galactosidase, lysosomal
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM eitetcoa m
constant: false
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r0539
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#

metaR FTHFLm
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (25902.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.4.3 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
modifier: MODEL1310110031#
reversible: true
fast: false
name: formate-tetrahydrofolate ligase, mitochondrial
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269

metaM 3dodtricoa m
name: 3,6,9-dodecatrienoylcoa
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB11123
constant: false
is: C05279
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR PROSTGD2t
is described by: ECO:0000269
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110031#
name: prostaglandin transport via bicarbonate countertransport
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false
reactant: MODEL1310110031#
type: Reaction

metaM ade e
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
has only substance units: false
name: adenine
initial concentration: 1.0
is: CHEBI:16708
is: SBO:0000247
type: Species
is: HMDB00034
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f0445b9a_5618_4684_ad49_5412f168b737
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: B3KT70
is encoded by: hsa:80201
constant: false
is: SBO:0000252
type: Species
name: HKDC1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_06a08055_fc13_4d96_af66_06d1a3253238
is encoded by: hsa:768
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: CA9
type: Species
initial concentration: NaN
is: Q16790

metaM 10fthf6glu e
is: SBO:0000247
type: Species
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00224
is: CHEBI:58190
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4eddb7de_86e0_411a_907d_5ea959b60849
initial concentration: NaN
is: Q6ZWT7
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: MBOAT2
type: Species
is encoded by: hsa:129642
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_8d3154f1_75f9_41ee_92ba_d7d955e21895
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: B4DK61
initial amount: NaN
type: Species
is encoded by: hsa:51
name: ACOX1
constant: false

metaR RETt
type: Reaction
is: SBO:0000185
name: Retinol transport via faciliated diffusion
product: MODEL1310110031#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR COQ7m
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: Ubiquinone biosynthesis COQ7
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT

metaM f6p c
is: C00085
initial amount: NaN
constant: false
is: HMDB00124
is: CHEBI:57579
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: D-Fructose 6-phosphate

metaM ddeccrn e
type: Species
initial concentration: 1.0
is: HMDB02250
notes: FORMULA: C19H37NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false
name: lauroyl carnitine
has only substance units: false
boundary condition: false

metaR PYDXNK
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
is: SBO:0000176
name: pyridoxine kinase
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.35

metaR PI45P5P
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110031#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6d10a6f4_c093_4073_9d60_a413fcdca0d4
is: SBO:0000252
type: Species
is: Q16348
name: SLC15A2
initial amount: NaN
is encoded by: hsa:6565
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR 4ABUTtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
kinetic law: MODEL1310110031#
reversible: true
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
name: 4-aminobutanoate mitochondrial transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_a423c484_e857_4004_b0b0_b1f50d179f02
constant: false
is: O43916
name: CHST1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8534
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaM abt c
is: CHEBI:18403
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01851
name: L-arabinitol
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: SBO:0000247

metaR PRGNLONEtm
is: SBO:0000185
is described by: ECO:0000000
name: pregnenolone intracellular transport
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
type: Reaction

metaR FATP7t
modifier: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false

metaM HC10852 r
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM didp n
initial concentration: 1.0
boundary condition: false
is: HMDB03536
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
constant: false
type: Species
is: CHEBI:28823
name: dIDP
is: SBO:0000247

metaR RE3626M
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
name: RE3626
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false

metaM ade c
has only substance units: false
is: C00147
constant: false
is: CHEBI:16708
name: Adenine
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00034
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_7220d85c_3149_40b8_ab0b_a8c16ae2230d
name: SLC4A5
is: Q9BY07
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:57835

metaM 3aib D m
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: D-3-Amino-isobutanoate
is: HMDB02299
is: C03265
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
initial concentration: 1.0

metaR FAOXC16080m
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110031#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110031#
fast: false

metaR RE3346C
reactant: MODEL1310110031#
name: RE3346
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e4698b64_0eea_4d25_9e63_71dcf52abe51
is: P11908
is encoded by: hsa:5634
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: PRPS2
is: SBO:0000252

metaM c12dccoa x
initial amount: NaN
boundary condition: false
is: HMDB03712
initial concentration: 1.0
type: Species
is: SBO:0000247
name: dodecanedioylcoa
has only substance units: false
constant: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5

metaM 4hphac e
is: CHEBI:48999
is: HMDB00020
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
initial concentration: 1.0
has only substance units: false
name: 4-hydroxyphenylacetate
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_3bab492e_edb5_4148_b6ba_2d4fe563cfc4
has only substance units: false
type: Species
is encoded by: hsa:3162
constant: false
is: SBO:0000252
is: Q6FH11
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: HMOX1

http://identifiers.org/biomodels.db/MODEL1310110031#_163e8c7f_41e3_4d40_bc0a_01f834dbfc36
is: E9PB82
has only substance units: false
name: HSD17B4
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:3295
constant: false

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f267c143_a017_44f6_a2a5_f01be4ec2003
boundary condition: true
has only substance units: false
name: SLC7A8:SLC3A2
constant: false
initial amount: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:23428
initial concentration: NaN
has part: Q9UHI5

metaM ksi pre30 g
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: C00130
constant: false
is: HMDB00175
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 30
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_c43f2e1e_24af_4bdf_a7e0_06769e33f258
initial amount: NaN
boundary condition: true
name: AMPD2
is: SBO:0000252
has only substance units: false
is: B2RB47
initial concentration: NaN
is encoded by: hsa:271
type: Species
constant: false

metaR GCC2cm
reversible: true
is: SBO:0000176
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110031#
name: glycine-cleavage complex (lipoamide), mitochondrial
reactant: MODEL1310110031#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b91b1db4_3fa5_4add_aeca_46c91f5ffa77
is encoded by: hsa:6574
initial amount: NaN
name: SLC20A1
boundary condition: true
is: Q8WUM9
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaM hyptaur c
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00965
name: Hypotaurine
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16668
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2ec173be_e3c7_4209_a806_17822a2f5f01
constant: false
is: A4D0W4
name: AASS
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10157
boundary condition: true
initial amount: NaN
type: Species

metaR PTDCACRNCPT2
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction
name: pentadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: false

metaR C161OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_ac2fd9e8_f175_48c5_bb6b_238cdd684f32
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:343
name: AQP8
is: SBO:0000252
constant: false
is: O94778
type: Species
has only substance units: false

metaR AG13T17g
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0a496a25_3319_40fd_9a26_548631689ab1
type: Species
initial concentration: NaN
is: O00443
is encoded by: hsa:5286
has only substance units: false
is: SBO:0000252
constant: false
name: PIK3C2A
initial amount: NaN
boundary condition: true

metaM 13dampp c
name: trimethylenediaminium
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
initial concentration: 1.0
is: CHEBI:57484
boundary condition: false
type: Species
is: HMDB00002

metaR RE3367E
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE3367
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_ae2e888e_4f71_4452_ae02_128762016f9a
is: B3KVA3
constant: false
is encoded by: hsa:112724
name: RDH13
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR PTDCACRNCPT1
modifier: MODEL1310110031#
name: carnitine fatty-acyl transferase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
fast: false
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_3ec03253_918a_4c69_a33b_e691e887303e
type: Species
constant: false
is: Q9P1E4
initial concentration: NaN
is encoded by: hsa:4122
is: SBO:0000252
has only substance units: false
boundary condition: true
name: MAN2A2
initial amount: NaN

metaM pap g
is: HMDB00061
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: CHEBI:58343
initial amount: NaN
initial concentration: 1.0
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_860d6212_f995_4c81_86bd_b487508cdb69
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6579
is: P46721
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: SLCO1A2

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM Rtotal2coa c
boundary condition: false
has only substance units: false
is: CHEBI:60377
initial amount: NaN
constant: false
is: C00055
is: HMDB00095
is: SBO:0000247
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
name: R total 2 coenzyme A
initial concentration: 1.0
type: Species

metaM eicostet e
initial concentration: 1.0
initial amount: NaN
type: Species
name: eicosatetranoic acid
is: HMDB02177
has only substance units: false
is: CHEBI:36033
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1
boundary condition: false

metaM pacald c
boundary condition: false
initial concentration: 1.0
is: CHEBI:16424
constant: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
has only substance units: false
is: HMDB06236
initial amount: NaN
type: Species
name: phenylacetaldehyde

metaR FAOXC164x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_59ea99a0_e99b_4ea3_8ff3_e215d176699a
name: SLC25A22
type: Species
initial concentration: NaN
is: Q9H936
is encoded by: hsa:79751
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM 2docopencoa x
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa

metaM ethamp r
initial amount: NaN
is: HMDB00224
is: CHEBI:58190
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
name: O-phosphonatoethanaminium(1-)

metaM 4hphac c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
is: CHEBI:48999
is: HMDB00020
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM c4crn x
boundary condition: false
has only substance units: false
is: HMDB02013
name: butyryl carnitine
is: C02862
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
is: http://identifiers.org/pubchem.compound/213144

http://identifiers.org/biomodels.db/MODEL1310110031#_6f455902_3a6b_4b6d_ae40_872cb5e23ecd
is: Q6UWQ5
name: LYZL1
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:84569
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_11eec8de_069c_44e6_bdb2_289a55d3c1ca
type: Species
is: SBO:0000252
is encoded by: hsa:5464
is: Q15181
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PPA1

metaM atp x
boundary condition: false
type: Species
is: C00002
initial amount: NaN
name: ATP(4-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57299
is: HMDB00538
constant: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM kdn c
notes: FORMULA: C9H15O9 CHARGE: -1 INCHI: InChI=1/C9H16O9/c10-2-5(13)7(15)8(16)6(14)3(11)1-4(12)9(17)18/h3,5-8,10-11,13-16H,1-2H2,(H,17,18)/t3-,5-,6+,7+,8+/m0/s1
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00425
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid

metaM 3ttetddcoa m
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: HMDB02014
is: SBO:0000247
name: 3-hydroxy trans5,8tetradecadienoyl coa
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_d925a1ce_3203_4a7f_99d7_8de6695ab9de
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: HAGHL
boundary condition: true
is encoded by: hsa:84264
type: Species
initial amount: NaN

metaM nicrnt c
is: C01185
initial concentration: 1.0
has only substance units: false
name: Nicotinate D-ribonucleotide
type: Species
is: HMDB01132
constant: false
is: CHEBI:57502
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: SBO:0000247

metaR SQLEr
name: Squalene epoxidase, endoplasmic reticular (NADP)
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.13.132
type: Reaction
reversible: false

metaR ORNt4m
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
fast: false
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110031#
modifier: MODEL1310110031#
name: ornithine mitochondrial transport exchange with citruline

metaR SPHMYLNtg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: sphingomyelin intracellular transport
product: MODEL1310110031#
is: SBO:0000185
type: Reaction

metaR DCTPtn
is: SBO:0000185
name: dCTP diffusion in nucleus
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110031#
fast: false

metaM c12dc x
name: dodecanedioyl carnitine
is: HMDB11123
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C19H34NO6 CHARGE: -1
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C05279

metaM pac c
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
initial amount: NaN
name: phenylacetate
type: Species
initial concentration: 1.0
boundary condition: false

metaR PROt4 2 r
is: SBO:0000185
is described by: ECO:0000006
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
reversible: true

metaR DNDPt22m
fast: false
name: dTDP transport via dUDP antiport
reactant: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false

metaM eicostet c
initial concentration: 1.0
is: HMDB02177
is: CHEBI:36033
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: eicosatetranoic acid
notes: FORMULA: C20H31O2 CHARGE: -1
has only substance units: false
type: Species

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_80c5d797_bb3c_458a_87a7_958e1e3e0b02
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:847
name: CAT
has only substance units: false
boundary condition: true
is: P04040
is: SBO:0000252

metaR ALASERNaEx
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110031#

metaR GLYt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
is described by: ECO:0000269
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
name: glycine transport via sodium symport
reversible: false
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#

metaR ADRNCOAtx
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
type: Reaction
is: SBO:0000185
product: MODEL1310110031#
reversible: true

metaM pram c
is: HMDB01128
type: Species
boundary condition: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
constant: false
has only substance units: false
is: C03090
name: 5-Phospho-beta-D-ribosylamine
is: CHEBI:58681
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r0426
is: SBO:0000176
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.34

metaR GLYCTO1p
fast: false
product: MODEL1310110031#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: Glycolate oxidase, peroxisome
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is version of: http://identifiers.org/ec-code/1.1.3.15

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR r0309
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
product: MODEL1310110031#
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6b3bacf7_f6c1_4e59_8023_2f623d79d82a
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_b0ed84fc_99e2_4057_94c8_25c0bf604a6f
is: SBO:0000252
initial amount: NaN
is: B7Z6S9
name: GBA
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2629
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_77ab0b3a_9af0_4c13_b552_31998bba0add
is: G3XAD7
is encoded by: hsa:1583
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: CYP11A1

metaR ARACHDCOAtx
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185

metaR HMGLm
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: hydroxymethylglutaryl-CoA lyase
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
fast: false

metaM didp c
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
is: HMDB03536
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28823

metaR TRPt4
is described by: ECO:0000304
is: SBO:0000185
reversible: false
type: Reaction
name: L-tryptophan transport in via sodium symport
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110031#_c8e81c8d_d7b3_4817_a55a_fc8d889d53b2
initial concentration: NaN
initial amount: NaN
name: PKLR
is: SBO:0000252
is encoded by: hsa:5313
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_906a85a3_19f1_4f02_9a83_1510edb0977d
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_328cdafc_3eab_413e_9786_d448069ab438
is: A8K0T6
is encoded by: hsa:55512
boundary condition: true
name: SMPD3
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_7e6e1581_a394_4458_9048_188b7d9231ac
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: E7EPT3
is encoded by: hsa:501
is: SBO:0000252
name: ALDH7A1

metaR PGLer
modifier: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110031#
product: MODEL1310110031#

metaM dgsn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
type: Species
is: C00330
constant: false
initial concentration: 1.0
is: CHEBI:17172
boundary condition: false
is: HMDB00085
initial amount: NaN
name: Deoxyguanosine
is: SBO:0000247

metaM HC02214 e
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
initial amount: NaN
name: prostaglandin-f1alpha
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b827cd55_5868_4302_9ffa_caa60a5815d0
name: FUT8
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: G3V5N0
type: Species
is encoded by: hsa:2530
has only substance units: false
constant: false
is: SBO:0000252

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1df15c70_1b79_4599_b8d1_09966f89c5d2
initial amount: NaN
initial concentration: NaN
type: Species
name: PPT1
constant: false
is: Q6FGQ4
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5538

metaR FACOAL226
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is: SBO:0000176
name: fatty-acid--CoA ligase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false

metaR INSTt4 2
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
product: MODEL1310110031#
is described by: ECO:0000006
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
reversible: true
name: inositol transport via sodium symport

metaM c3dc e
type: Species
is: SBO:0000247
name: malonyl carnitine
notes: FORMULA: C10H16NO6 CHARGE: -1
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB02095

metaR r2443
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110031#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a8906726_584c_46ee_b29b_198e7bbfbbb4
initial concentration: NaN
initial amount: NaN
has part: P38117
name: ETFA:ETFB
boundary condition: true
has only substance units: false
is encoded by: hsa:2109
is: SBO:0000297
type: Species
constant: false

metaR FACOAL224
fast: false
name: fatty-acid--CoA ligase
reversible: true
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r0424
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
fast: false
kinetic law: MODEL1310110031#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000

metaM arachdcoa x
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB06523
is: CHEBI:57368
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)

metaM CE5788 e
initial concentration: 1.0
boundary condition: false
is: CHEBI:27485
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
constant: false
is: HMDB02710
has only substance units: false
name: kinetensin 1-7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_9b0c2b0a_e705_4d2b_98c3_637cac0ad6c8
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9091
has part: B2RAU6
is encoded by: hsa:51227
boundary condition: true
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
is encoded by: hsa:5277
has part: P57054
is encoded by: hsa:5279

metaR C6CRNtcx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR RE3079X
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3079
modifier: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_49cbc5a5_64e2_4e28_83a0_85ddcf41f7e8
boundary condition: true
is: E9KL48
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: GLUD1
is encoded by: hsa:2746
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_e1b1954e_c0ea_465f_ad6a_e4f08626d67f
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51557
name: LGSN
is: Q5TDP6
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_7f2cca1d_d7ef_4ff8_92a5_d9e27f5dadc6
type: Species
is encoded by: hsa:3176
name: HNMT
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: P50135
initial amount: NaN

metaM ipdp x
constant: false
name: isopentenyl diphosphate(3-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347
type: Species
has only substance units: false
initial amount: NaN

metaR r0308
fast: false
reversible: false
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000176

metaM ksi deg13 l
is: CHEBI:57455
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 13
is: HMDB01354
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: SBO:0000247
has only substance units: false
constant: false

metaM HC02214 c
constant: false
is: CHEBI:28852
type: Species
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR KHK
kinetic law: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
reversible: false
name: ketohexokinase
is version of: http://identifiers.org/ec-code/2.7.1.3
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
fast: false

metaR BTNPL
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.3.4.10
name: holocarboxylase synthestase (biotin protein ligase)
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#

metaM dgsn c
has only substance units: false
type: Species
initial concentration: 1.0
is: C00330
constant: false
boundary condition: false
is: CHEBI:17172
is: HMDB00085
name: Deoxyguanosine
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247

metaR LPS2e
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
name: lipase, extracellular
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
reversible: false
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR GLYCt
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: glycerol transport via channel
type: Reaction
reactant: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

metaM hs deg24 l
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H50NO26 CHARGE: -1
name: GlcNAc-GlcA-(Gal)2-Xyl
constant: false
is: CHEBI:16126
boundary condition: false

metaR SEBCOACROT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_a4cee550_c27a_4ad5_ba2f_b6130313fc23
is encoded by: hsa:10861
has only substance units: false
boundary condition: true
name: SLC26A1
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_812561a2_6d41_4f05_91db_9d422d90f447
is: SBO:0000252
initial concentration: NaN
is: P30613
has only substance units: false
constant: false
boundary condition: true
name: PKLR
initial amount: NaN
is encoded by: hsa:5313
type: Species

metaM c3dc c
name: malonyl carnitine
type: Species
notes: FORMULA: C10H16NO6 CHARGE: -1
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB02095

metaR ALASm
name: 5-aminolevulinate synthase
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.37
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
is: SBO:0000176

metaM m4mpdol U r
boundary condition: false
has only substance units: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN

metaR EX c3dc
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR NACHEX9ly
is described by: ECO:0000000
modifier: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110031#
fast: false

metaM HC02217 e
initial amount: NaN
type: Species
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR ASCBt4
is described by: ECO:0000269
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
reversible: true
name: L-ascorbate transport via proton symport
fast: false

metaM pentcoa m
is: C00888
name: pentanoylcoa
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB13037
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_f48bd41c_29d3_4f53_bef7_660717617f71
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: ODC1
is: P11926
is encoded by: hsa:4953
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_14847a54_9e9e_4241_8dee_4bb08b02fa65
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: ACAT1
type: Species
is: P24752
is: SBO:0000252
is encoded by: hsa:38
has only substance units: false

metaR NCAMDe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinamide at the basolateral surface
type: Reaction

metaM galgalgalthcrm hs e
boundary condition: false
is: HMDB00143
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
type: Species
constant: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: C00124
is: CHEBI:0
has only substance units: false
initial concentration: 1.0

metaR FAOXC101x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaM 3ttetddcoa c
initial concentration: 1.0
constant: false
is: HMDB02014
initial amount: NaN
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
type: Species
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_01203302_1f7b_48b1_8672_7d0a9d3a8e44
is encoded by: hsa:594
is encoded by: hsa:1629
initial amount: NaN
initial concentration: NaN
has part: B4DP47
has only substance units: false
boundary condition: true
name: DBT:DLD:BCKDHA:BCKDHB
type: Species
constant: false
has part: P21953
is: SBO:0000297
is encoded by: hsa:593
has part: P11182

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR GLUDxm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NAD) (mitochondrial)
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
reversible: true

metaM dheas c
is: SBO:0000247
is: CHEBI:57905
initial concentration: 1.0
constant: false
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01032

metaM mthgxl c
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: methylglyoxal
is: HMDB01167
is: CHEBI:17158
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
boundary condition: false
type: Species

metaM mi1p D c
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
is: HMDB02985
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110031#_3928e0a9_c272_44d0_92c4_beb7ad8d3650
initial amount: NaN
is: SBO:0000252
is: Q13510
is encoded by: hsa:427
has only substance units: false
initial concentration: NaN
type: Species
name: ASAH1
boundary condition: true
constant: false

metaM cdpdag hs m
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: CHEBI:58332

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR r0650
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110031#

metaM HC02217 c
boundary condition: false
name: prostaglandin-g2
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:27647
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaM HC00591 m
initial concentration: 1.0
has only substance units: false
is: CHEBI:16769
name: 2-oxoglutaramate
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaM galgalgalthcrm hs g
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
is: CHEBI:26174
has only substance units: false
initial concentration: 1.0

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110031#
name: Beta oxidation of med/long chain fatty acid
reversible: false
type: Reaction
is: SBO:0000176

metaM ddeccrn c
boundary condition: false
initial amount: NaN
name: lauroyl carnitine
constant: false
is: HMDB02250
notes: FORMULA: C19H37NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR METyLATthc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM trdox c
is: CHEBI:18191
is: SBO:0000247
is: C00343
has only substance units: false
name: Oxidized thioredoxin
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r0651
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110031#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_c82e85ba_8e68_4e91_8f9f_84c6005609dc
is encoded by: hsa:3633
is: P32019
has only substance units: false
constant: false
name: INPP5B
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM pi x
initial amount: NaN
initial concentration: 1.0
is: CHEBI:43474
is: SBO:0000247
name: hydrogenphosphate
type: Species
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_661536f9_16d0_4aa7_bf74_c1a90f5aa5f0
boundary condition: true
type: Species
is encoded by: hsa:9963
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC23A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_eed476ec_5371_4192_b844_371055a743e0
is: SBO:0000252
has only substance units: false
name: _AA081045_1_e
is encoded by: hsa:AA081045
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM cholcoar x
is: HMDB02178
type: Species
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM hepcoa m
boundary condition: false
is: HMDB12969
has only substance units: false
constant: false
name: heptanoylcoa
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_17297635_6026_4cc1_b9a1_fdee5b6d58cc
name: ACADVL
is: P49748
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:37
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR FAOXC121x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_931f0f51_fa3b_43e8_8462_876dc8079e70
is: SBO:0000252
is: P23919
has only substance units: false
is encoded by: hsa:1841
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: DTYMK

metaR BAMPPALDOX
is: SBO:0000176
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is described by: ECO:0000212

metaM pi r
initial concentration: 1.0
name: hydrogenphosphate
is: CHEBI:43474
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
is: HMDB00973
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_521aa8f5_5704_4989_9235_4bf3328f21ee
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: O43488
is encoded by: hsa:8574
name: AKR7A2
type: Species
initial concentration: NaN
constant: false

metaM ksi deg41 l
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
type: Species
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 41

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaM ksi deg34 l
constant: false
is: SBO:0000247
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 34
is: HMDB01354
is: CHEBI:57455
boundary condition: false

metaM maltpt e
is: C02052
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial amount: NaN
is: HMDB01296
is: SBO:0000247
type: Species
name: maltopentaose
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_e010384e_aa32_46ff_bb18_96fc9cf0503c
boundary condition: true
is: SBO:0000252
is: Q9UMR5
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: PPT2
is encoded by: hsa:9374

metaR C161CPT12
modifier: MODEL1310110031#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
is: SBO:0000176
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#

metaR GALtly
name: galactose efflux from lysosome
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
type: Species
constant: false
has only substance units: false
is: HMDB00174
initial amount: NaN
is: SBO:0000247
is: CHEBI:18287
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1

metaR SRTNt6 2 r
fast: false
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110031#
type: Reaction
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#

metaM pydx e
boundary condition: false
name: Pyridoxal
has only substance units: false
type: Species
is: HMDB01545
is: SBO:0000247
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
initial amount: NaN
constant: false
is: C00250
initial concentration: 1.0
is: CHEBI:17310

metaR r2389
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_ca519105_0248_41a0_b50f_e6e9b16b9d07
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000297
is encoded by: hsa:8818
type: Species
has part: Q9P2X0
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54344
name: DPM3:DPM1:DPM2

metaR VLCSr
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction

metaR IDOAASE3ly
reversible: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
reversible: true
reactant: MODEL1310110031#
type: Reaction
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

metaM c4crn m
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
is: C02862
name: butyryl carnitine
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB02013

metaR NDP8
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.9
name: nucleoside-diphosphatase (dUDP)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR RE0453M
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
name: RE0453
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b688b008_ab8d_4590_9522_87b8ceca7b02
is: O75746
name: SLC25A12
has only substance units: false
is encoded by: hsa:8604
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM retinal c
initial amount: NaN
is: CHEBI:15035
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
initial concentration: 1.0
name: retinal
constant: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_17a69bbb_8f77_4fcf_b742_0c586b2e3417
is: Q8NCL4
name: GALNT6
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:11226
is: SBO:0000252

metaR G14T17g
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR DGCHOLte
is: SBO:0000185
name: bile acid intracellular transport
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction

metaR TALA
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.2
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110031#
name: transaldolase
reversible: true
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_dddc3c11_fdd7_49f6_834a_4fae54941a66
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2954
name: GSTZ1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: O43708

http://identifiers.org/biomodels.db/MODEL1310110031#_cf122a59_67f5_4f69_b2a9_e56ff0741985
is: SBO:0000252
name: ACSL5
boundary condition: true
initial amount: NaN
is encoded by: hsa:51703
has only substance units: false
constant: false
is: Q9ULC5
type: Species
initial concentration: NaN

metaM malthx e
initial amount: NaN
name: Maltohexaose
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false
type: Species
initial concentration: 1.0
is: C01936
is: SBO:0000247
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5041

metaR r0643
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
fast: false
reversible: true
reactant: MODEL1310110031#

metaM pydx c
initial amount: NaN
is: HMDB01545
is: CHEBI:17310
is: SBO:0000247
constant: false
is: C00250
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
has only substance units: false
name: Pyridoxal
initial concentration: 1.0
type: Species

metaR CHOLPtg
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: choline phosphate intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110031#
is: SBO:0000185
reversible: true
type: Reaction

metaR RE0453N
reversible: true
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
name: RE0453

http://identifiers.org/biomodels.db/MODEL1310110031#_866ba982_f7c2_4986_9f8b_5f038426eaba
is encoded by: hsa:1544
name: CYP1A2
is: P05177
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110031#
is described by: ECO:0000000
fast: false
reversible: true
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#

metaM glac r
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
constant: false
initial concentration: 1.0
is: CHEBI:18268
boundary condition: false
initial amount: NaN
has only substance units: false
name: D-glucurono-6,3-lactone
is: SBO:0000247
type: Species

metaR RTOTAL2FATPc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM eicostetcoa m
has only substance units: false
is: C16164
boundary condition: false
initial concentration: 1.0
type: Species
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: SBO:0000247
initial amount: NaN
constant: false

metaR r0642
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
product: MODEL1310110031#
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reversible: true
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9ec5409e_1c47_4fbe_8d10_55f0bede858d
name: _AI697028_1_m
is encoded by: hsa:AI697028
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_78e7e356_dae7_412c_bb6c_c4158b821296
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: PGM3
is: SBO:0000252
is encoded by: hsa:5238
is: B4DX94
boundary condition: true
initial concentration: NaN

metaR r2387
is: SBO:0000185
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR DOLDPP Ler
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.43
reactant: MODEL1310110031#
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_2c1884b0_84ca_45d5_aaf8_88688f45939b
is encoded by: hsa:60490
initial concentration: NaN
boundary condition: true
name: PPCDC
is: SBO:0000252
is: Q96CD2
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaM galgalgalthcrm hs c
is: HMDB00143
is: CHEBI:12936
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
initial amount: NaN
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer

metaR RE1447M
kinetic law: MODEL1310110031#
fast: false
name: RE1447
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#

metaR r0311
modifier: MODEL1310110031#
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110031#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
fast: false
product: MODEL1310110031#

metaM atp c
name: ATP(4-)
has only substance units: false
is: SBO:0000247
is: CHEBI:30616
initial concentration: 1.0
is: C00002
is: HMDB00538
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaR DAGK hs
reversible: true
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
product: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_f22819c8_cf22_4d08_bb55_586cfe4dd0c7
is encoded by: hsa:AI824319
name: _AI824319_1_r
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM cholcoar r
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
boundary condition: false
is: CHEBI:58677
is: HMDB02178
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM ksi pre28 g
is: HMDB00175
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 28
is: C00130
is: CHEBI:58053
is: SBO:0000247
type: Species
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_3e516725_9ad9_45dd_a9f6_5da67fec6a1c
is: Q9BYC2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:64064
type: Species
has only substance units: false
name: OXCT2
constant: false
initial amount: NaN

metaM gal1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00645
is: CHEBI:58336
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110031#_7d506d4c_3741_4051_9401_d681dd0a3c09
constant: false
is encoded by: hsa:3938
is: SBO:0000252
name: LCT
is: P09848
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaR r0310
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110031#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176

metaR FACOAL80i
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase (octanoate)
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3

metaR r2386
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110031#
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#

metaM pi n
is: SBO:0000247
boundary condition: false
name: hydrogenphosphate
is: HMDB00973
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:43474
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e067b8b4_c696_4e89_a348_39a48917852f
is encoded by: hsa:5331
boundary condition: true
name: PLCB3
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: G5E960

metaM 3hdcoa m
constant: false
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
type: Species
name: (S)-3-Hydroxydecanoyl-CoA
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

metaR TMNDNCCPT2
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110031#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_e3f0c797_62f2_4820_9872_9b064c2c878a
is encoded by: hsa:3419
has only substance units: false
constant: false
initial amount: NaN
is: P50213
is: SBO:0000252
name: IDH3A
initial concentration: NaN
boundary condition: true
type: Species

metaR PRISTtx
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: prist peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110031#
fast: false
type: Reaction

metaM 3tetd7ecoacrn e
name: 3-hydroxy tetradecenoyl-7-carnitine
constant: false
type: Species
notes: FORMULA: C21H39NO5 CHARGE: 0
has only substance units: false
initial amount: NaN
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_89da69d6_0031_49c8_8e61_e94ee9c59e9d
is encoded by: hsa:79071
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: ELOVL6
is: Q9H5J4
type: Species
is: SBO:0000252
initial concentration: NaN

metaM cdpdag hs c
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
initial amount: NaN
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaR TMNDNCCPT1
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110031#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false

metaR 3DPHBH1
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
fast: false
reversible: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_15e8b9f5_0070_409e_8ffe_42f46c18c628
has only substance units: false
constant: false
is encoded by: hsa:9791
type: Species
is: SBO:0000252
initial concentration: NaN
name: PTDSS1
boundary condition: true
is: P48651
initial amount: NaN

metaM etfox m
type: Species
is: SBO:0000247
notes: FORMULA: R CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00151
is: CHEBI:16469
name: Electron transfer flavoprotein oxidized

metaM atp e
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
is: C00002
is: SBO:0000247
is: HMDB00538
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r2385
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_562ef9ec_266c_448c_999f_27b75af60b4b
constant: false
name: PTGDS
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:5730
initial concentration: NaN
is: P41222
is: SBO:0000252
type: Species

metaR MAN6PI
modifier: MODEL1310110031#
reversible: true
name: mannose-6-phosphate isomerase
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.3.1.8
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
kinetic law: MODEL1310110031#
fast: false
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

metaR r0434
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false

metaM m7mpdol U r
type: Species
initial concentration: 1.0
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
has only substance units: false
boundary condition: false
is: CHEBI:37636
is: SBO:0000247
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
initial amount: NaN

metaM 4h2oglt m
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
is: CHEBI:17742
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_403b3896_c5ae_4f02_aef3_4ce202baf158
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9UJS0
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:10165
name: SLC25A13

http://identifiers.org/biomodels.db/MODEL1310110031#_31d30c33_38cc_4a4f_941b_963200aa6161
is: Q92911
initial concentration: NaN
name: SLC5A5
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6528
has only substance units: false

metaR S6T8g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false

metaM for r
name: Formate
type: Species
is: SBO:0000247
is: C00058
is: HMDB00142
has only substance units: false
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR RE3269C
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.48
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: RE3269

metaM mercppyr c
initial amount: NaN
is: HMDB01368
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: CHEBI:57678
name: 3-mercaptopyruvate
type: Species
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR r0647
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
product: MODEL1310110031#
name: Spontaneous reaction
fast: false
kinetic law: MODEL1310110031#

metaR r2384
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
modifier: MODEL1310110031#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110031#

metaM HC01609 e
constant: false
is: SBO:0000247
is: CHEBI:28766
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
name: UroporphyrinogenI

http://identifiers.org/biomodels.db/MODEL1310110031#_8e978dab_c5e4_4432_a6fc_062725390f3c
has only substance units: false
constant: false
is encoded by: hsa:8818
type: Species
name: DPM2
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O94777

metaM 3tetd7ecoacrn c
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02014
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_84a3e60b_f8cc_4bad_a694_83ccb58abfc5
type: Species
is: SBO:0000252
constant: false
is: Q7KYS4
is encoded by: hsa:5143
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PDE4C

http://identifiers.org/biomodels.db/MODEL1310110031#_cca48aa3_9a12_4589_a469_048965db9b70
constant: false
is encoded by: hsa:5146
initial concentration: NaN
type: Species
name: PDE6C
initial amount: NaN
has only substance units: false
is: P51160
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_c42eb2a0_ca88_4b55_a286_120306d8c14a
is encoded by: hsa:55350
has only substance units: false
boundary condition: true
initial concentration: NaN
name: VNN3
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6afc8a4d_ee38_4cd0_ad10_66ee711472aa
has part: P22392
name: NME1:NME2
constant: false
has only substance units: false
boundary condition: true
type: Species
has part: P15531
is encoded by: hsa:4830
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:4831
initial amount: NaN

metaM CE5236 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
boundary condition: false
is: CHEBI:28002
initial amount: NaN
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
is: HMDB03952
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR LEUKTRE4t
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
name: leukotriene E4 transport
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_8817ed3f_ba85_493c_a576_5690096fef7f
is: SBO:0000252
initial amount: NaN
name: SLC27A2
is: O14975
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:11001
type: Species

metaM xu1p D c
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB06534
is: SBO:0000247
name: D-Xylulose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
initial amount: NaN
initial concentration: 1.0

metaM thcholstoic m
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
is: HMDB03873
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_2d32f5d5_925f_4454_8647_46c61e48363a
is: SBO:0000252
constant: false
type: Species
is: P24310
has only substance units: false
name: COX7A1
is encoded by: hsa:1346
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR VLCSp
reversible: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000269
name: Very-long-chain-fatty-acid-CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110031#_a0a31f15_43a3_4e36_ac1c_5b3f970e862f
is: Q8IWX5
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:130367
constant: false
is: SBO:0000252
boundary condition: true
name: SGPP2

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
is: CHEBI:26174
initial concentration: 1.0
is: SBO:0000247
name: nLc7Cer
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
type: Species
has only substance units: false
constant: false
boundary condition: false

metaM tddedicoa m
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/5280771
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: trans3,6dodecadienoylcoa

metaM 3hexdtetcoa x
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110031#_70e60309_33c9_4ae7_8fe9_54bc7b0d7e3f
type: Species
has only substance units: false
is: E9KL44
initial concentration: NaN
is encoded by: hsa:3030
boundary condition: true
name: HADHA
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: blood group intracellular transport
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
reversible: true

metaR C162ACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_231ce79b_4c4f_4257_a6a7_4ac04ed3406d
is encoded by: hsa:4728
constant: false
name: NDUFS8
initial amount: NaN
boundary condition: true
is: O00217
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM 4ppan c
initial concentration: 1.0
is: C03492
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01016
name: D-4'-Phosphopantothenate
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247

metaR FUMtm
is: SBO:0000185
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
name: fumarate transport, mitochondrial
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR PI45PLC
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110031#
is: SBO:0000176

metaR r2382
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110031#
modifier: MODEL1310110031#

metaM Ser Gly Ala X Gly l
is: SBO:0000247
constant: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: CHEBI:36005
type: Species
initial concentration: 1.0
is: HMDB02183

metaR r0758
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
modifier: MODEL1310110031#
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB03134
initial amount: NaN
constant: false
is: C05552
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: SBO:0000247

metaR B3GNT310g
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000254
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR DDPGAm
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is: SBO:0000176
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
type: Reaction
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR Htg
reversible: true
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)

metaM trdox m
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
constant: false
has only substance units: false
is: CHEBI:18191

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_cb46932e_9c36_424e_8c00_072b6af7cc6f
boundary condition: true
initial concentration: NaN
is: Q9BQG2
has only substance units: false
initial amount: NaN
name: NUDT12
is encoded by: hsa:83594
constant: false
type: Species
is: SBO:0000252

metaM 5aop m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
constant: false
has only substance units: false
is: CHEBI:17549
type: Species
name: 5-Amino-4-oxopentanoate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00430
initial amount: NaN
is: HMDB01149

http://identifiers.org/biomodels.db/MODEL1310110031#_49fa00f6_7d35_408f_9821_c165b8b32349
initial concentration: NaN
name: MAOA
type: Species
is: SBO:0000252
boundary condition: true
is: Q53YE7
initial amount: NaN
has only substance units: false
is encoded by: hsa:4128
constant: false

metaM leuktrA4 c
is: SBO:0000247
name: leukotriene A4(1-)
initial amount: NaN
boundary condition: false
is: CHEBI:57463
is: HMDB01337
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_c75953a7_01ec_41ed_b17d_f47e332a24b7
is: SBO:0000252
is: P36021
is encoded by: hsa:6567
type: Species
boundary condition: true
initial concentration: NaN
name: SLC16A2
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_665641b4_dbf0_4e6a_a333_c7059cc39af7
is: SBO:0000252
is: Q96AT9
constant: false
name: RPE
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6120
initial amount: NaN
type: Species

metaR FAOXC102m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM urate e
is: C00366
initial amount: NaN
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: CHEBI:17775
initial concentration: 1.0
is: HMDB00289
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Urate

metaR r0757
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.4.16
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110031#

metaM m4mpdol U c
type: Species
initial concentration: 1.0
is: CHEBI:37633
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_4039d41a_14ce_41dc_a399_85f18629d273
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q13613
name: MTMR1
boundary condition: true
is encoded by: hsa:8776
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_a322dcd1_b787_48ae_880c_3cfa140d658a
type: Species
has only substance units: false
name: SLC26A1
is encoded by: hsa:10861
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM ksi deg29 l
constant: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: CHEBI:12936
type: Species
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 29
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR GLRASE
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
name: glucuronolactone reductase
reversible: true
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_5e2a3e62_f17c_4288_b8a6_9b0becdb5cef
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI222095
boundary condition: true
name: _AI222095_1_e
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_23134aa7_3384_4166_ad36_f563ac40841d
initial concentration: NaN
has only substance units: false
is encoded by: hsa:762
is: Q6FHI7
name: CA4
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR FAOXC164m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r0756
product: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.3.1
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR CERT2rt
kinetic law: MODEL1310110031#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
name: ceramide transport protein
type: Reaction
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#

metaM pi l
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:43474
is: HMDB00973
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110031#_c8c6d5f7_8e3e_40d7_a543_23a7c901cc8e
boundary condition: true
name: PYCR2
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:29920
type: Species
is: SBO:0000252
is: Q96C36
initial concentration: NaN

metaM lthstrl r
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: 5alpha-cholest-7-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: HMDB01170
boundary condition: false
has only substance units: false
is: CHEBI:17168
initial amount: NaN

metaR r2380
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
is: SBO:0000185

metaR TETDECE1CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR KSII CORE2tly
name: keratan sulfate II (core 2) transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110031#

metaM atp m
type: Species
is: C00002
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57299
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
initial concentration: 1.0

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM Rtotal3coa c
name: R total 3 Coenzyme A
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01448

metaM leuktrA4 e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
is: HMDB01337
has only substance units: false
name: leukotriene A4(1-)
initial concentration: 1.0
constant: false
is: CHEBI:57463

http://identifiers.org/biomodels.db/MODEL1310110031#_60431a81_5418_4fbf_9d89_daa01df77275
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: _AI971023_1_c
constant: false
is encoded by: hsa:AI971023
is: SBO:0000252
initial concentration: NaN

metaR r0755
modifier: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000

metaR r0541
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
fast: false
modifier: MODEL1310110031#

metaM mi1p D n
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02985
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species

metaR CYTK4n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
name: cytidylate kinase (dCMP,GTP),nuclear
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110031#

metaM pi m
is: HMDB00973
type: Species
has only substance units: false
name: hydrogenphosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00009
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_fa2f4e41_9b31_4830_b5ff_944bba0947f8
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: P27987
name: ITPKB
is encoded by: hsa:3707

metaR FBA
reversible: true
modifier: MODEL1310110031#
name: fructose-bisphosphate aldolase
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
kinetic law: MODEL1310110031#
is described by: ECO:0000134
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: blood group intracellular transport
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR EHGLATm
type: Reaction
reactant: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: false
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000212

metaR FUT18g
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.69
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

metaR MG3er
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_ed6f30cd_8302_48c0_9fad_e55cc84b344d
initial concentration: NaN
name: ACADL
is: SBO:0000252
is: P28330
is encoded by: hsa:33
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaM HC01180 c
name: D-tagatofuranose 1,6-bisphosphate(4-)
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: CHEBI:58694
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaR DM gpi sig er
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR PTE3x
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: false
name: peroxisomal acyl-CoA thioesterase
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction

metaM thcholstoic r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
is: CHEBI:18402
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR RETFA
reversible: false
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110031#
name: retinol acyltransferase
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b9ccf621_afdc_44e4_948b_88309387e261
name: PDE5A
is: O76074
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8654
constant: false

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
product: MODEL1310110031#
fast: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR PTRCOX1
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.21
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
modifier: MODEL1310110031#
reversible: false
name: Putrescine:oxygen oxidoreductase (deaminating)
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000176

metaR HACD9m
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false

metaR RE1447N
name: RE1447
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_a486dbe0_84bd_4996_ab44_054dc430f9a4
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q01433
is encoded by: hsa:271
name: AMPD2
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR ACACT1rm
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM CE5869 e
initial concentration: 1.0
is: CHEBI:27485
is: SBO:0000247
initial amount: NaN
name: lysyl-proline
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
is: HMDB02710

metaR r0754
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR SERCYSNaEx
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000269
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
fast: false
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185

metaR 34DHXMANDACOX NADP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110031#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_035f455e_626c_4f75_9638_49e28c2d7f5a
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:522
name: ATP5J
initial concentration: NaN
is: SBO:0000252
is: Q6IB54

metaM HC01434 x
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58931
initial amount: NaN
initial concentration: 1.0
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false

metaR LNLCCRNt
reactant: MODEL1310110031#
type: Reaction
fast: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_b67099b6_3afe_417d_88e4_82644f9676e8
initial concentration: NaN
is encoded by: hsa:1636
constant: false
is: B4DKH4
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: ACE

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00174
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18287
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_94a7720a_d406_4b32_887c_c515ad3fa3fe
is: SBO:0000252
is encoded by: hsa:5139
constant: false
name: PDE3A
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q14432
type: Species

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_b1bbde43_0e36_4cff_9c1d_6acabe642559
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ZADH2
is: Q8N4Q0
type: Species
is encoded by: hsa:284273

metaR r0753
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110031#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reversible: true
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000176

metaM hexe3coa x
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB06522
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
name: 3-hexenoylcoa

metaR ADNt
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
name: adenosine facilated transport in cytosol
reversible: true
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
type: Reaction

metaR NACHEX21ly
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110031#

metaM pi g
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
is: HMDB00973
is: SBO:0000247
initial amount: NaN
name: hydrogenphosphate
has only substance units: false
type: Species
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR DCYTt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
name: deoxycytidine transport via diffusion
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_b6fcc7b6_936a_461b_86fb_9b039545f643
is: B2R6S5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CMPK1
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:51727
constant: false

metaR ENGASE2ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
fast: false
reversible: false
reactant: MODEL1310110031#

metaR OCTAt
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
name: Octanoate transport via diffusion
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
product: MODEL1310110031#

metaM atp n
is: CHEBI:57299
name: ATP(3-)
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
is: HMDB00538

metaM eicostetcoa c
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
name: eicosatetranoyl coenzyme A
is: C16164
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_a0b3074c_7da9_4f34_8a36_9733de38445a
initial amount: NaN
is encoded by: hsa:50484
boundary condition: true
constant: false
is: Q7LG56
type: Species
name: RRM2B
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR PCHOLP hs
name: choline phosphatase
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
kinetic law: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
is: SBO:0000176
type: Reaction

metaM fdp c
initial concentration: 1.0
is: HMDB01058
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: D-Fructose 1,6-bisphosphate
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
initial amount: NaN
is: C00354
is: CHEBI:16905

metaR r0752
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
modifier: MODEL1310110031#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR COQ6m
modifier: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110031#
name: Ubiquinone biosynthesis monooxgenase COQ6
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
kinetic law: MODEL1310110031#
is: SBO:0000176

metaR LEUKTRF4t
is: SBO:0000185
product: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110031#
name: leukotriene F4 transport
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial concentration: 1.0
is: HMDB00660
is: SBO:0000247
is: CHEBI:15824
is: C00095
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110031#_56f89533_57af_4c27_893a_a73b32beafe8
type: Species
boundary condition: true
initial concentration: NaN
is: Q9Y259
is encoded by: hsa:1120
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: CHKB

metaR DOCO13EFATP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR r0202
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110031#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

metaM urate c
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
is: CHEBI:17775
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: Urate
is: SBO:0000247
is: HMDB00289
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1c3bb2e6_c366_4969_9592_615f5ca6a64f
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9GZR5
is encoded by: hsa:6785
boundary condition: true
constant: false
name: ELOVL4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5f1f66bd_d260_4b69_a438_f71db171ef48
type: Species
is encoded by: hsa:10423
initial amount: NaN
boundary condition: true
constant: false
is: O14735
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CDIPT

http://identifiers.org/biomodels.db/MODEL1310110031#_c1cc71e5_1e22_444b_b132_35ee1343add6
constant: false
is: SBO:0000252
is: Q02127
type: Species
has only substance units: false
initial concentration: NaN
name: DHODH
is encoded by: hsa:1723
boundary condition: true
initial amount: NaN

metaR RE0453C
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176
name: RE0453
fast: false

metaM ipdp c
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: C00129
boundary condition: false
is: CHEBI:128769
is: HMDB01347
initial amount: NaN
name: Isopentenyl diphosphate
initial concentration: 1.0
type: Species
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r0545
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
kinetic law: MODEL1310110031#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#

metaM h2o g
initial concentration: 1.0
is: HMDB02111
has only substance units: false
is: SBO:0000247
is: CHEBI:15377
initial amount: NaN
type: Species
name: water
constant: false
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

http://identifiers.org/biomodels.db/MODEL1310110031#_2dfed4d3_7e37_4287_831c_dfefcb0c2ef1
initial concentration: NaN
has only substance units: false
is: O60658
constant: false
boundary condition: true
is: SBO:0000252
name: PDE8A
is encoded by: hsa:5151
initial amount: NaN
type: Species

metaM dtmp m
is: C00364
constant: false
boundary condition: false
has only substance units: false
is: HMDB01227
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: CHEBI:26999
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_fa731ab8_4703_4c98_8849_fc8387ab1939
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ABAT
is encoded by: hsa:18
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM lnlccrn c
is: SBO:0000247
has only substance units: false
constant: false
name: Linoleyl carnitine
initial concentration: 1.0
is: HMDB06469
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
boundary condition: false

metaR GALASE10ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_7418180c_5229_4466_be8d_c490b98dc580
initial amount: NaN
is encoded by: hsa:1491
initial concentration: NaN
boundary condition: true
name: CTH
is: P32929
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_63ca9470_f4d7_44f6_ab1c_00f890a4aaf8
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q7Z7M8
initial amount: NaN
is: SBO:0000252
name: B3GNT8
has only substance units: false
is encoded by: hsa:374907

metaR BTNt2
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
fast: false
name: Biotin reversible transport via proton symport
product: MODEL1310110031#

metaR FUM
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110031#
is: SBO:0000176
name: fumarase

metaM crm hs c
initial concentration: 1.0
has only substance units: false
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false

metaR P45027A14m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is: SBO:0000176
kinetic law: MODEL1310110031#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110031#
product: MODEL1310110031#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1

http://identifiers.org/biomodels.db/MODEL1310110031#_ec8a66b2_0868_4c29_b599_9e32725fa5e8
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PRDX1
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:5052

metaR RDH2a
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
modifier: MODEL1310110031#
fast: false
reversible: true
name: retinol dehydrogenase (9-cis,NADPH)
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110031#

metaR FAOXC163x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaR FAOXC12DCTc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4836f5f8_19c5_4f7e_9a52_6c0420b9c1c6
is: SBO:0000252
name: LDHAL6B
type: Species
is encoded by: hsa:92483
initial concentration: NaN
constant: false
has only substance units: false
is: Q9BYZ2
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_247984d8_3538_4c00_8afd_a2651b06458a
initial concentration: NaN
is encoded by: hsa:AI769281
name: _AI769281_1_e
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM 3oddcoa x
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
is: HMDB03937
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2066bcf1_03d1_444f_b432_59601059436f
is encoded by: hsa:221823
boundary condition: true
is: P21108
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PRPS1L1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_0cc95072_d9d4_44fa_9ef6_013d62b1b700
type: Species
initial amount: NaN
name: PPAP2B
constant: false
is: SBO:0000252
is: O14495
initial concentration: NaN
is encoded by: hsa:8613
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_6f7589dd_cd55_45fe_96e1_42431c2ced3e
has only substance units: false
is encoded by: hsa:8869
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: Q9UNP4
name: ST3GAL5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_4dcc1e4e_b716_4ed7_a0fc_61b98dfd5d28
constant: false
boundary condition: true
is: SBO:0000252
name: _AI631997_1_m
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI631997

http://identifiers.org/biomodels.db/MODEL1310110031#_986b8240_44bd_4f6c_9bd4_34d8f0f06344
constant: false
initial amount: NaN
is encoded by: hsa:J03866
is: SBO:0000252
type: Species
initial concentration: NaN
name: _J03866_1_m
boundary condition: true
has only substance units: false

metaM h2o e
is: CHEBI:15377
initial concentration: 1.0
name: H2O
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: C00001
is: HMDB02111

metaM ksi deg14 l
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00143
is: CHEBI:12936
constant: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
name: keratan sulfate I, degradation product 14
is: SBO:0000247
initial amount: NaN

metaM L2aadp6sa c
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: CHEBI:17917
name: L-allysine
initial concentration: 1.0
is: SBO:0000247

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM leuleu c
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/94244
type: Species
is: SBO:0000247
name: Leucylleucine
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR ILETAm
is described by: ECO:0000269
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM 2ddecdicoa x
is: HMDB11123
has only substance units: false
is: C05279
name: 2,6-dodecadienoylcoa
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM h2o2 x
type: Species
is: HMDB03125
has only substance units: false
is: CHEBI:16240
name: Hydrogen peroxide
initial concentration: 1.0
is: SBO:0000247
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial amount: NaN
constant: false

metaM HC02216 c
is: CHEBI:28922
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
boundary condition: false
is: SBO:0000247

metaR SERTHRNaEx
reactant: MODEL1310110031#
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269

metaM ksii core4 pre6 g
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 6
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
type: Species
boundary condition: false

metaM cs a deg5 l
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15936
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C23H36O24S CHARGE: -2

metaM sphings l
has only substance units: false
boundary condition: false
is: CHEBI:57756
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)
initial concentration: 1.0
is: HMDB00252

metaR FUCASEe
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_65831788_db8c_4850_8aa5_bddb500ff875
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2592
initial concentration: NaN
is: B4E097
name: GALT
has only substance units: false
type: Species
is: SBO:0000252

metaR r0549
type: Reaction
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a21d0ac4_3650_4602_8674_2d44e3e95f2e
boundary condition: true
initial concentration: NaN
is: Q16718
has only substance units: false
name: NDUFA5
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4698

metaR CYTK8n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110031#
fast: false
name: cytidylate kinase (CMP,dATP),nuclear
type: Reaction

metaR GGLUCT
reactant: MODEL1310110031#
is described by: ECO:0000269
name: gamma-glutamylcyclotransferase
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
reversible: false
product: MODEL1310110031#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.4

http://identifiers.org/biomodels.db/MODEL1310110031#_21932427_4e92_4065_98d2_a3a02ed8e19c
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: AK4
is: SBO:0000252
is encoded by: hsa:205
has only substance units: false

metaR GLCAASE4ly
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaM ksi deg7 l
name: keratan sulfate I, degradation product 7
is: HMDB01354
initial concentration: 1.0
is: CHEBI:57455
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c0fd188e_6887_42db_b187_87b53f87a625
is encoded by: hsa:R14373
name: _R14373_1_x
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM leuleu e
name: Leucylleucine
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C12H24N2O3 CHARGE: 0

metaR HS4ly
modifier: MODEL1310110031#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: heparan-N-sulfatase, lysosomal

metaR FAOXC102x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR HSD17B42x
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false

metaR r2021
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
type: Reaction

metaR 5MTHFt2le
is: SBO:0000185
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
name: 5-methyltetrahydrofolate transport via anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4a0f7e7f_80ee_4d33_820e_7af0463a25dc
name: FOLR1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348

metaM dec47dicoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR GLCMter
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110031#
name: glucose transport via membrane vesicle
kinetic law: MODEL1310110031#

metaR biomass reaction
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
name: biomass_reaction
reversible: false
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_93ca66bf_548c_486d_8f56_95b4fe7dbd19
name: PNP
initial concentration: NaN
is: SBO:0000252
is: P00491
boundary condition: true
is encoded by: hsa:4860
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM crm hs g
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
type: Species
name: N-acylsphingosine

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR ICDHxm
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.41
reactant: MODEL1310110031#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110031#
name: Isocitrate dehydrogenase (NAD+)
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.41 Confidence Level: 0 AUTHORS: PMID:10601238,PMID:14555658 NOTES:The reaction may be reversible. Strathern shows the reactions as irreversible. IF. Biochemical, Genetic

metaR DHCRD1
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reactant: MODEL1310110031#
name: dihydroceramide desaturase
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176
reversible: false
fast: false

metaR CYSTA
is described by: ECO:0000304
type: Reaction
fast: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reversible: true
kinetic law: MODEL1310110031#
name: cysteine transaminase

http://identifiers.org/biomodels.db/MODEL1310110031#_6258cf8f_ef61_45ef_9424_b6a58703cdb3
is: Q8TEQ8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84720
name: PIGO
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM hxcoa c
is: SBO:0000247
is: HMDB13130
constant: false
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species

metaM cytd m
has only substance units: false
is: HMDB00089
is: CHEBI:17562
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
name: cytidine
initial amount: NaN

metaM 20ahchsterol m
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: CHEBI:1296
is: HMDB06283
has only substance units: false
name: 20-hydroxycholesterol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_78e94b27_22ce_489a_8a44_b03c17358da7
has only substance units: false
name: ALDH9A1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:223
is: P49189
boundary condition: true
constant: false
type: Species

metaR LDH D
name: D-lactate dehydrogenase
is described by: ECO:0000304
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4

metaR HTDCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_10af4814_7e5d_436f_aa63_034b55cf8be5
is encoded by: hsa:34
initial amount: NaN
boundary condition: true
is: P11310
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: ACADM
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_436a54b8_47e0_40d7_930a_a222e96bde37
is encoded by: hsa:83530
initial amount: NaN
type: Species
has only substance units: false
name: _83530_1_c
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM CE5161 r
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
is: SBO:0000247
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
has only substance units: false
constant: false
is: CHEBI:57923
initial amount: NaN
boundary condition: false

metaR r0774
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_f2a1d29d_fbb2_4265_b5ea_17005be53b2e
is encoded by: hsa:1737
has only substance units: false
is: SBO:0000252
is: Q86YI5
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: DLAT

metaR NCNt
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
name: Na+/Ca2+-NH4+ exchange
fast: false
is described by: ECO:0000269

metaM crm hs e
type: Species
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
name: N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110031#_739cb845_bb40_4692_a27d_68e6fbdef6ee
is: Q6IBK2
is encoded by: hsa:3795
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: KHK
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR THMPPtm
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
fast: false
is described by: ECO:0000000
name: Thiamine diphosphate transport in via anion antiport, mitochondria
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR C8DCc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR r2355
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_3a6c1cfe_1a80_47f7_a797_373cc746505e
name: ACOT8
is: SBO:0000252
is encoded by: hsa:10005
is: O14734
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species

metaM f1p c
is: HMDB01076
initial amount: NaN
name: D-Fructose 1-phosphate
is: CHEBI:18105
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C01094
constant: false
boundary condition: false

metaR LINKDEG1ly
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_aaa2e09b_49ab_4561_8300_f8d5fbc52623
initial amount: NaN
type: Species
name: PEMT
initial concentration: NaN
is encoded by: hsa:10400
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM CE1925 e
is: CHEBI:57923
name: 3'-carboxy-alpha-chromanol
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM Rtotal2 e
is: C00255
initial amount: NaN
boundary condition: false
name: R total 2 position
constant: false
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00244
is: CHEBI:3554

metaM ksi deg27 l
initial concentration: 1.0
name: keratan sulfate I, degradation product 27
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:12936
is: HMDB00143

metaR ASPTA
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
reactant: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR r0339
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaR S6TASE12ly
is: SBO:0000176
kinetic law: MODEL1310110031#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
reactant: MODEL1310110031#

metaR FAOXC226C225x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4617dd1f_85b8_4cd7_b71f_8ff8602b43d5
initial concentration: NaN
is: Q9HCQ5
name: GALNT9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:50614
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM pydam c
is: CHEBI:57761
boundary condition: false
is: C00534
type: Species
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
constant: false
has only substance units: false
name: Pyridoxamine
is: SBO:0000247
initial concentration: 1.0
is: HMDB01431
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6aee27fd_f92e_46cf_bc53_861c4742a129
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:292
constant: false
is: Q6NVC0
initial concentration: NaN
boundary condition: true
name: SLC25A5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_20379753_9d97_4916_beec_b7a659c5df9d
is: O95822
initial concentration: NaN
is encoded by: hsa:23417
name: MLYCD
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM 2ddecdicoa m
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB11123
is: C05279
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: 2,6-dodecadienoylcoa
initial concentration: 1.0

metaR r2356
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM xol7ah c
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:2290
initial concentration: 1.0
is: SBO:0000247
is: HMDB06892
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451

metaM hs deg11 l
name: heparan sulfate, degradation product 11
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
type: Species
is: CHEBI:57737
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00868
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM c10dc c
is: HMDB00651
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: sebacoyl carnitine
notes: FORMULA: C17H30NO6 CHARGE: -1
initial concentration: 1.0
boundary condition: false

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110031#
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
reversible: true
product: MODEL1310110031#

metaR VACCCRNt
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_80c3a99e_79e5_4e2a_aa3f_779ff1f32087
has only substance units: false
is encoded by: hsa:8527
name: DGKD
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR GALGALGALTHCRMtg
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110031#
name: galgalgalthcrm hs intracellular transport
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110031#

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110031#
type: Reaction
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110031#
is: SBO:0000185

metaR r2357
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110031#

metaR ABO4g
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.37
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000176

metaM thcholstoic c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_93a3608c_c921_4b7a_a960_e1ad58b81827
initial concentration: NaN
initial amount: NaN
name: PYCRL
boundary condition: true
type: Species
is encoded by: hsa:65263
constant: false
has only substance units: false
is: Q53H96
is: SBO:0000252

metaR FATP8t
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
name: fatty acid electroneutral transport
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110031#

metaR XYLUR
name: xylulose reductase
product: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.10
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_84607a1e_1b3e_4468_bd4f_225f65e72fcf
is encoded by: hsa:5147
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: PDE6D
initial concentration: NaN
is: O43924

metaR SPMS
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.5.1.16
reversible: false
name: spermidine synthase

http://identifiers.org/biomodels.db/MODEL1310110031#_0ea2c3a1_b2b8_4528_a649_2726f91c51e8
is encoded by: hsa:8802
is: P53597
has only substance units: false
name: SUCLG1
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR C10CRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR r2131
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#

metaR r0127
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.16
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction

metaR r1912
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
modifier: MODEL1310110031#

metaM ksii core2 deg3 l
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 3
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: CHEBI:12936
constant: false
is: HMDB00143
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_98c737cf_01cf_446f_b842_4891af9c378c
initial concentration: NaN
is encoded by: hsa:218
is: P30838
type: Species
name: ALDH3A1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110031#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110031#
type: Reaction

metaR MECOALm
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.5
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
modifier: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000212

metaR RE0688E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
name: RE0688
reversible: false
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_cd3e00b8_b1c3_4ac5_b05b_b4a3b8677be5
has only substance units: false
name: DLST
is encoded by: hsa:1743
is: P36957
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR FAOXC204
product: MODEL1310110031#
fast: false
reversible: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaM sphings c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
constant: false
is: HMDB00252
is: CHEBI:57756
is: SBO:0000247
boundary condition: false
name: sphingosine(1+)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_fba786b0_9dcb_4c07_a387_a2ab178abc90
constant: false
name: PIGF
is: Q6IB04
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5281
boundary condition: true

metaR OCD11COACPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_2d9010d9_b8d5_4f25_8847_e648619a9971
boundary condition: true
initial amount: NaN
is encoded by: hsa:5136
is: P54750
is: SBO:0000252
constant: false
name: PDE1A
initial concentration: NaN
has only substance units: false
type: Species

metaR CSAPASEly
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is: SBO:0000176
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR GALGALGALTHCRMte
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
name: galgalgalthcrm hs transport
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00257
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: CHEBI:16094

metaM apoC c
constant: false
boundary condition: false
is: SBO:0000247
name: Apocarboxlase (no lys residue)
is: HMDB11111
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:33190

metaR r2132
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_76e8bf98_2693_4afe_ae90_c9966b84f3f5
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54187
type: Species
name: NANS
is: Q9NR45
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_d241ee17_819d_417a_82c8_382012ab64b3
is encoded by: hsa:5145
constant: false
is: SBO:0000297
is encoded by: hsa:5149
initial concentration: NaN
initial amount: NaN
has only substance units: false
has part: Q13956
is encoded by: hsa:5158
type: Species
name: PDE6A:PDE6H:PDE6B
has part: P16499
has part: B7Z9T9
boundary condition: true

metaR MI1PS
name: myo-Inositol-1-phosphate synthase
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/5.5.1.4
modifier: MODEL1310110031#
is: SBO:0000176

metaM pro D e
is: HMDB03411
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16313
initial amount: NaN
boundary condition: false
constant: false
name: D-proline

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000

metaM dgdp m
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58595
is: SBO:0000247
name: dGDP(2-)
is: HMDB00960
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM pre prot r
is: SBO:0000247
name: glycophosphatidylinositol (GPI)-anchored protein precursor
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB03125
initial amount: NaN
boundary condition: false
is: CHEBI:16240
notes: FORMULA: XY CHARGE: 0

metaR r0129
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
type: Species
is: CHEBI:3303
constant: false
is: C00001
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
name: H2O

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1db92bce_60c2_4787_918e_f3caa2684047
name: DGUOK
initial amount: NaN
is: SBO:0000252
is: E5KSL6
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1716
constant: false

metaR r2133
product: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_c6e46ec2_dd55_49ba_b6fd_3bd1b899de8f
is encoded by: hsa:481
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: A3KLL5
type: Species
name: ATP1B1
is: SBO:0000252
constant: false
has only substance units: false

metaM dgchol c
type: Species
name: glycochenodeoxycholate
initial amount: NaN
has only substance units: false
is: HMDB00637
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false

metaM stcrn m
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: HMDB00848
initial amount: NaN
boundary condition: false
name: stearoylcarnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM docohexcoa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
name: 2,4,7,10,13,16-docosahexenoylcoa

metaM Ssq23epx r
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: (S)-2,3-epoxysqualene
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: HMDB01188
initial amount: NaN
is: CHEBI:15441
has only substance units: false

metaM sphgn c
initial amount: NaN
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: CHEBI:57817
is: HMDB00269
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: sphinganine(1+)

http://identifiers.org/biomodels.db/MODEL1310110031#_dfffb7ab_d99d_47d4_b291_521cd3d4e3db
type: Species
initial amount: NaN
is encoded by: hsa:54511
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: HMGCLL1
is: Q9NT06

metaM dsmsterol r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
initial concentration: 1.0
name: desmosterol
is: HMDB02719
initial amount: NaN
constant: false
is: CHEBI:17737
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_416dece4_f0ea_44ac_b499_a6050189d18e
is encoded by: hsa:5236
boundary condition: true
name: PGM1
type: Species
constant: false
is: B4DPV0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_c403096f_e152_4cc1_ae80_ef4790e49a35
initial amount: NaN
initial concentration: NaN
is: Q15392
type: Species
constant: false
has only substance units: false
name: DHCR24
is: SBO:0000252
is encoded by: hsa:1718
boundary condition: true

metaM h2o2 n
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
initial amount: NaN
is: CHEBI:16240
is: HMDB03125
name: hydrogen peroxide
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaM dgdp n
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00960
constant: false
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
is: CHEBI:58595
initial concentration: 1.0

metaR HYXNt
modifier: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
reactant: MODEL1310110031#
name: Hypoxanthine transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_f6a4ae87_0217_455c_b5d6_2ca1ef9f8fb2
initial amount: NaN
is: Q9BQL0
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:594
name: BCKDHB
has only substance units: false

metaR PROD2m
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
name: Proline dehydrogenase (m)
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#

metaR FUMAC
is described by: ECO:0000269
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.7.1.2
name: fumarylacetoacetase
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#

metaR TYRCBOX
modifier: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reactant: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000134
name: L-Tyrosine carboxy-lyase

metaM 3snpyr m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3-Sulfinopyruvate
is: CHEBI:1665
initial amount: NaN
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: SBO:0000247
type: Species
is: HMDB02332

metaM 3hdcoa c
is: HMDB00651
is: SBO:0000247
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM saccrp L m
constant: false
name: L-saccharopinate(1-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
boundary condition: false
type: Species
is: HMDB00279
is: CHEBI:57951
has only substance units: false

metaM Rtotal2 c
is: HMDB00095
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
name: R total 2 position
is: CHEBI:60377
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00055
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_95ae3b57_6425_4281_b94a_ad8d6860499b
is: SBO:0000252
initial amount: NaN
name: FASN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: P49327
is encoded by: hsa:2194
has only substance units: false

metaM c226coa c
constant: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
name: cervonyl coenzyme A
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
boundary condition: false

metaM CE1936 e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: spermine dialdehyde
constant: false
type: Species
is: CHEBI:36781
has only substance units: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
boundary condition: false

metaM ksi pre12 g
type: Species
is: C00130
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 12
has only substance units: false
is: HMDB00175
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247

metaM xolest2 hs e
name: cholesterol ester
boundary condition: false
is: CHEBI:17002
initial amount: NaN
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaM dgchol e
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: glycochenodeoxycholate
is: CHEBI:36252
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
is: SBO:0000247

metaR GALU
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction

metaR r1916
kinetic law: MODEL1310110031#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110031#
is: SBO:0000185
reversible: false
reactant: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
constant: false
type: Species
is: HMDB00673
boundary condition: false
name: linoleate
is: CHEBI:30245
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM h2o2 m
initial amount: NaN
is: CHEBI:16240
has only substance units: false
is: C00027
boundary condition: false
is: HMDB03125
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species

metaR NADS2
name: NAD synthase (glutamine-hydrolysing)
is version of: http://identifiers.org/ec-code/6.3.5.1
fast: false
is described by: ECO:0000269
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_30213ee9_eb69_4690_b5d9_e3e402a4b460
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O94925
boundary condition: true
is encoded by: hsa:2744
name: GLS
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e8d3fc7b_b4dc_4502_b392_258c1686759b
has only substance units: false
is encoded by: hsa:6783
is: P49888
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: SULT1E1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_eb9ea6c2_0e9f_444d_9350_79b913be736d
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:W74642
boundary condition: true
name: _W74642_1_c
is: SBO:0000252

metaR NODe
reversible: true
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110031#

metaM retinal 11 cis c
is: CHEBI:16066
is: HMDB02152
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR MI1PP
modifier: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000176
name: myo-inositol 1-phosphatase
type: Reaction
reversible: false
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_3a1e88e4_ad2d_42e1_adf9_6069777fa2d8
initial amount: NaN
name: ATP1A2
is: SBO:0000252
is: P50993
has only substance units: false
is encoded by: hsa:477
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR PIK3
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
name: phosphatidylinositol 3-kinase
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction

metaR r2136
reversible: false
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110031#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110031#

metaR NACHEX2ly
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_cb22ec9b_bd01_4f93_87af_6670816a0b28
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q10472
is encoded by: hsa:2589
name: GALNT1

metaR GALT
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
name: galactose-1-phosphate uridylyltransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_07c931c3_81e3_4193_90ee_1ff55d129db5
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4125
is: SBO:0000252
type: Species
constant: false
name: MAN2B1
initial concentration: NaN
is: O00754

http://identifiers.org/biomodels.db/MODEL1310110031#_8a9afd78_b163_425a_abcd_67b5c6b4359d
has only substance units: false
name: ALDH7A1
is encoded by: hsa:501
initial amount: NaN
is: E7EPT3
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaM biliverd c
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
boundary condition: false
initial amount: NaN
name: biliverdin(2-)
is: SBO:0000247
is: HMDB01008
constant: false
initial concentration: 1.0
is: CHEBI:57991
has only substance units: false
type: Species

metaR LDH L
fast: false
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#

metaR MANtg
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: mannose efflux from Golgi apparatus
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
has only substance units: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
initial concentration: 1.0
is: CHEBI:61648

metaR r0611
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reversible: true
is version of: http://identifiers.org/ec-code/1.2.3.1
product: MODEL1310110031#
type: Reaction

metaR C161CPT22
reversible: false
fast: false
kinetic law: MODEL1310110031#
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110031#_8347ec43_2c6f_4be1_b959_342aacf6c82c
is: SBO:0000252
is encoded by: hsa:4706
initial amount: NaN
type: Species
is: O14561
constant: false
name: NDUFAB1
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR NDPK9
reversible: true
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:IDP)
modifier: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110031#
is: SBO:0000176

metaR TAGt
name: triacylglycerol transport
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185

metaM docohexcoa m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false

metaR EX ddecrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaM apoC m
is: SBO:0000247
is: CHEBI:32551
is: HMDB00182
boundary condition: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM c12dccoa c
name: dodecanedioylcoa
initial concentration: 1.0
is: HMDB00623
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial amount: NaN

metaR r0610
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reactant: MODEL1310110031#
fast: false
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true

metaM gal14acglcgalgluside hs g
name: Lactoneotetraosylceramide
boundary condition: false
initial concentration: 1.0
is: CHEBI:17103
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_56afb01f_7ae1_4551_b623_58444072edd5
name: LDHD
is: Q86WU2
is encoded by: hsa:197257
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM HC01231 c
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
initial concentration: 1.0

metaM ppcoa m
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57392
is: HMDB01275
name: Propanoyl-CoA
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false

metaM C02528 c
name: chenodeoxycholate
initial amount: NaN
is: HMDB00518
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
type: Species

metaR 34HPPOR
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
modifier: MODEL1310110031#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_135757e6_1308_4186_b6aa_9cd2445d0c71
type: Species
is: Q4J699
is encoded by: hsa:491
name: ATP2B2
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2137
fast: false
reversible: true
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
modifier: MODEL1310110031#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

metaM dlnlcgcrn c
initial amount: NaN
constant: false
name: dihomo-gamma-linolenyl carnitine
is: HMDB01311
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_a7ded9a1_5c7e_47a6_9953_f9b02c81d072
constant: false
name: PIK3R2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O00459
is encoded by: hsa:5296
initial amount: NaN
type: Species

metaR RE3242R
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
name: RE3242
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaR RE2814M
name: RE2814
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
product: MODEL1310110031#

metaM 3hexdcoa m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03932
name: 3-hydroxyhexadecanoylcoa
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: C05258
type: Species

metaM hx2coa m
type: Species
is: C05998
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB06870
initial amount: NaN
is: SBO:0000247
name: trans-Hex-2-enoyl-CoA
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
initial concentration: 1.0

metaM crm hs r
is: CHEBI:52639
name: N-acylsphingosine
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
has only substance units: false

metaR GPIMTer U
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_0e531167_9e5f_4329_aceb_d914f310df5e
name: GGT1
type: Species
is: SBO:0000252
initial concentration: NaN
is: P19440
is encoded by: hsa:2678
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR 5ADTSTSTERONESte
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110031#
name: sulfonated testosterone transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
kinetic law: MODEL1310110031#
fast: false

metaM ksii core2 pre2 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 2
is: CHEBI:58053
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00175
has only substance units: false
type: Species
notes: FORMULA: C39H63N3O28X CHARGE: -1

metaR S6T9g
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110031#
reversible: false

metaR DM Ser Thr ly
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaM dec47dicoa m
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: 4,7-decadienoylcoa
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM eitetcoa x
initial amount: NaN
boundary condition: false
has only substance units: false
name: 5,8,11,14-eicosatetraenoylcoa
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_99dcb1ef_1b79_4f2d_8063_42cef6dfb6f0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: ABP1
is: P19801
is encoded by: hsa:26
boundary condition: true
constant: false

metaM cs b l
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
is: HMDB02183
is: CHEBI:36005
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR FACOAL181i
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: C181 fatty acid activation
is: SBO:0000176
modifier: MODEL1310110031#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110031#_2487c0da_02e0_4070_ae27_8de3c6ce52e9
initial concentration: NaN
type: Species
name: SLC6A9
is encoded by: hsa:6536
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: P48067
is: SBO:0000252

metaR r0345
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110031#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
product: MODEL1310110031#
reversible: true

metaR PItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: phosphate transport, nuclear
fast: false
product: MODEL1310110031#
reversible: true

metaR SUCD1m
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110031#
reversible: true
name: succinate dehydrogenase
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110031#

metaM pro D c
initial amount: NaN
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: D-proline
is: CHEBI:16313
is: HMDB03411

http://identifiers.org/biomodels.db/MODEL1310110031#_e6fdb6b1_7ce1_490b_b09c_c2af14ac6ae5
is: Q01581
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3157
boundary condition: true
is: SBO:0000252
name: HMGCS1

metaR r2139
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR BILGLCURtr
name: glucuronidated compound transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
kinetic law: MODEL1310110031#

metaM 4abutn e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
name: 4-ammoniobutanal
is: SBO:0000247
has only substance units: false
is: HMDB01080
is: CHEBI:58264
type: Species
boundary condition: false

metaM dhap x
is: CHEBI:57642
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
type: Species
is: HMDB01473
is: C00111
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Dihydroxyacetone phosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_33a350e4_356c_4b88_88df_9e199520b381
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:204
name: AK2
is: SBO:0000252
initial amount: NaN

metaR PI345P3P
fast: false
is described by: ECO:0000000
modifier: MODEL1310110031#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_b8ee5816_7477_4722_a848_e7671faecabf
is: B3KXK1
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:115019
is: SBO:0000252
name: SLC26A9
initial concentration: NaN

metaR GBAl
reversible: false
type: Reaction
modifier: MODEL1310110031#
name: Glucosylceramidase
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
kinetic law: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.45

metaR r2352
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#

metaR NDPK5
reactant: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dGDP)
fast: false
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR S3TASE3ly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000

metaR FAEL204
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#

metaR HMGLx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
reversible: false
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
modifier: MODEL1310110031#
is: SBO:0000176

metaM c10dc x
type: Species
name: sebacoyl carnitine
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00651
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_485430ff_9e2b_49f5_bf78_4f5277b604b1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q13011
name: ECH1
is encoded by: hsa:1891
boundary condition: true
constant: false
type: Species

metaM thbpt4acam n
is: CHEBI:15374
constant: false
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB02281
initial amount: NaN
initial concentration: 1.0

metaR NDPK6
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110031#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction

metaM cs e deg3 l
type: Species
initial concentration: 1.0
notes: FORMULA: C37H53NO44S4 CHARGE: -6
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
initial amount: NaN

metaR RE0452M
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
name: RE0452
kinetic law: MODEL1310110031#
fast: false
reversible: true

metaM dodecanac c
constant: false
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00623
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM L2aadp6sa m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
name: L-allysine
is: HMDB01263
is: CHEBI:17917

metaR GLYSNAT5tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6f998e45_8041_4305_a3df_5a5ee9f70d1e
name: PIK3C3
constant: false
is: SBO:0000252
is encoded by: hsa:5289
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q8NEB9
type: Species

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
has only substance units: false
constant: false
is: C00555
is: SBO:0000247
is: CHEBI:58264
boundary condition: false
name: 4-Aminobutanal
is: HMDB01080
initial concentration: 1.0
type: Species

metaR FACOAL1832
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_2131eaad_bf26_4abb_8abc_53a928244494
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:760
boundary condition: true
type: Species
name: CA2
is: P00918

metaM dcmp c
is: CHEBI:57566
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00239
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
boundary condition: false

metaR r2354
is: SBO:0000185
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_c436df72_c3b2_4abc_be73_61ad12e310e8
boundary condition: true
constant: false
name: CTSA
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5476
is: P10619

metaR NDPK7
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#

metaR GBA
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
name: Glucosylceramidase
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reversible: false
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.45

metaM core2 g
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15876

metaR RE2814R
name: RE2814
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_0d736b16_db6d_4036_be23_712938183fa7
is encoded by: hsa:10654
constant: false
initial amount: NaN
name: PMVK
is: Q6FGV9
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM h2o x
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false
name: H2O
is: HMDB02111
is: CHEBI:15377
is: C00001
initial concentration: 1.0

metaM stcrn c
type: Species
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
constant: false
initial amount: NaN
name: stearoylcarnitine
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00848

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR NDPK8
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110031#
name: Nucleoside-diphosphate kinase (ATP:dADP)
type: Reaction
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaM 2docopencoa m
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_ba858461_6d64_43fc_8aea_750f40b8b3c2
initial amount: NaN
is encoded by: hsa:3032
boundary condition: true
has only substance units: false
type: Species
is: P55084
name: HADHB
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_0e225f65_76d4_4fe8_bfd4_b7c17ea06f5c
initial concentration: NaN
is encoded by: hsa:2591
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: Q14435
name: GALNT3

metaM C02528 e
initial amount: NaN
is: HMDB00518
boundary condition: false
constant: false
name: chenodeoxycholate
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

http://identifiers.org/biomodels.db/MODEL1310110031#_267d3b26_faf5_4496_9910_62f302564077
name: RPL36A
initial amount: NaN
is: P83881
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6173
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_2441455a_4bfb_4bb5_bab7_2d936874edc0
initial amount: NaN
is encoded by: hsa:80025
is: Q6P1K9
type: Species
name: PANK2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR r2353
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE1709
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176

metaM tdchola c
boundary condition: false
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:9407
type: Species
initial amount: NaN
name: taurochenodeoxycholate
is: HMDB00951

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM ksii core4 pre3 g
is: C00130
initial amount: NaN
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 3
initial concentration: 1.0
is: HMDB00175
boundary condition: false
type: Species
is: CHEBI:58053
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247

metaR RE0935E
modifier: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
name: RE0935
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000

metaM homoval m
is: SBO:0000247
initial amount: NaN
name: Homovanillate
constant: false
has only substance units: false
type: Species
is: HMDB00118
boundary condition: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial concentration: 1.0
is: CHEBI:545959

http://identifiers.org/biomodels.db/MODEL1310110031#_b6d4316d_7d46_44d8_bc1a_ba4264068c76
is: P09622
is encoded by: hsa:1738
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: DLD
boundary condition: true

metaM peamn c
initial amount: NaN
constant: false
is: HMDB12275
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:225237
name: 2-phenylethanaminium
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_88ef01ae_00b8_4778_860a_fbd5385342a1
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
name: ST3GAL3

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Linoleyl carnitine
has only substance units: false
boundary condition: false
is: HMDB06469
constant: false
initial amount: NaN

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4e3690ad_1b21_4ddb_bbf8_913d51bfd5f5
is: Q9UPR5
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6543
constant: false
type: Species
initial concentration: NaN
name: SLC8A2
is: SBO:0000252

metaR FUT15g
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
kinetic law: MODEL1310110031#
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.69
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1243d52f_182e_46d1_9278_61433924447e
has only substance units: false
constant: false
is encoded by: hsa:5277
type: Species
is: SBO:0000252
initial amount: NaN
name: PIGA
boundary condition: true
initial concentration: NaN

metaM 5mthf e
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:3729
is: C00440
is: HMDB01396
boundary condition: false
name: 5-Methyltetrahydrofolate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR GLXtm
product: MODEL1310110031#
reversible: true
name: glyoxylate transport, mitochondrial
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

metaM cs e deg6 l
initial amount: NaN
is: HMDB01354
is: CHEBI:57455
constant: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
has only substance units: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_5823466e_3613_49e9_a57d_e2981422ab2d
is encoded by: hsa:AA854479
name: _AA854479_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM h2o n
constant: false
boundary condition: false
is: CHEBI:15377
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02111
is: SBO:0000247
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR 34DHOXPEGt
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
product: MODEL1310110031#
type: Reaction
fast: false
is: SBO:0000185

metaM mi134p c
initial concentration: 1.0
is: HMDB01143
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
boundary condition: false

metaR CREATt4 2 r
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Creatine transport (sodium symport) (2:1)
modifier: MODEL1310110031#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_637ed65f_a48c_4721_a47f_16fb4228e6f3
initial amount: NaN
name: CANT1
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q8WVQ1
initial concentration: NaN
constant: false
is encoded by: hsa:124583
type: Species

metaR ICDHyrm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: Isocitrate dehydrogenase (NADP+)
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
product: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_7e8d1842_1882_4e80_a783_5acecd1dc2e9
boundary condition: true
name: ADCY8
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:114
is: Q4F7X0
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_3fb1d506_3319_4598_905a_74a83781a79c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3158
has only substance units: false
name: HMGCS2
is: P54868
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR VLCS2r
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110031#

metaR GLYtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
is described by: ECO:0000000
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
reversible: true

metaR RE1709C
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
name: RE1709

http://identifiers.org/biomodels.db/MODEL1310110031#_e9f7c3a1_76a8_4109_99a8_e71a63a917e8
name: ATP1A1:ATP1B3
initial amount: NaN
is encoded by: hsa:483
has part: B7Z3U6
initial concentration: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:476
boundary condition: true
has part: P54709
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_b2a6593b_c03e_4e5a_a309_fb8414088fbf
is: Q99999
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GAL3ST1
initial concentration: NaN
constant: false
is encoded by: hsa:9514

http://identifiers.org/biomodels.db/MODEL1310110031#_ebafe83d_07fe_40f4_a150_b99555273662
is encoded by: hsa:4952
initial amount: NaN
is: Q01968
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: OCRL
constant: false
is: SBO:0000252

metaR 7DHCHSTEROLtr
name: cholesterol precursor intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_2ade2614_9d73_4bac_b416_6d6b45a8dedb
initial amount: NaN
type: Species
name: _AD000092_1_c
boundary condition: true
is encoded by: hsa:AD000092
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_350372fa_5dcf_4308_ba90_e1f541522fc2
is: SBO:0000252
constant: false
is encoded by: hsa:6470
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SHMT1
type: Species
initial amount: NaN

metaM crm hs l
initial amount: NaN
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:52639
constant: false
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM tdchola e
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
type: Species
is: HMDB00951
is: SBO:0000247
boundary condition: false
name: taurochenodeoxycholate
initial concentration: 1.0
constant: false
is: CHEBI:9407

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR PItx
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
fast: false
name: Phosphate transporter, peroxisome
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57847
is: SBO:0000247
boundary condition: false
is: HMDB00304
has only substance units: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0de49704_8c1d_4790_b584_56ef08502ca9
name: COX5B
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q53YB7
is encoded by: hsa:1329
initial amount: NaN
constant: false

metaM maltttr e
is: C02052
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: SBO:0000247
type: Species
name: Maltotetraose
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01296

http://identifiers.org/biomodels.db/MODEL1310110031#_dedd578c_fd58_476b_920d_bc2df5ff4932
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR r0552
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM ksi pre8 g
is: CHEBI:28067
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 8
is: SBO:0000247
initial amount: NaN
constant: false

metaM h2o l
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02111
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: water
is: CHEBI:15377

http://identifiers.org/biomodels.db/MODEL1310110031#_fa00a5cf_6ebe_4b64_a796_2ab5967bacf7
name: GGT7
is: SBO:0000252
is encoded by: hsa:2686
has only substance units: false
is: A0PJJ9
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_888b290a_1deb_418a_83c3_1e9d95d14348
constant: false
initial amount: NaN
is: E2QRH8
is encoded by: hsa:5332
name: PLCB4
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR 5ADTSTSTERONESULT
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is: SBO:0000176
name: 5alpha-Dihydrotestosterone sulfotransferase

metaM grdp x
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:58057
is: HMDB01285
type: Species
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
constant: false
name: geranyl diphosphate(3-)
boundary condition: false

metaM dcmp n
is: HMDB01202
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
initial amount: NaN
is: CHEBI:57566
initial concentration: 1.0

metaM gullac r
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:17587
initial amount: NaN
is: SBO:0000247
is: HMDB03466
has only substance units: false
name: L-gulono-1,4-lactone
type: Species
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1

metaM dlnlcgcrn m
boundary condition: false
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
has only substance units: false
constant: false
is: SBO:0000247

metaM h2o m
type: Species
is: CHEBI:15377
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
initial concentration: 1.0
is: HMDB02111
is: C00001
name: H2O

metaM ppcoa c
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
name: Propanoyl-CoA
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01275
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57392

metaR PTCRTD
reactant: MODEL1310110031#
name: diffusion of putriscine into the endothelial cells
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
is described by: ECO:0000134
fast: false
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_4a274821_8c55_4595_a251_3cb9ee1c8651
is: SBO:0000252
constant: false
is: P00558
boundary condition: true
type: Species
name: PGK1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5230

metaR ST8SIA12
name: Beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_edc4192d_425e_4a6d_8b00_9e461e82cf1d
constant: false
type: Species
name: AMPD2
is encoded by: hsa:271
is: SBO:0000252
is: E9PNG0
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM h2o r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02111
initial amount: NaN
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: C00001
is: CHEBI:15377
name: H2O
constant: false

metaR B3GNT311g
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#

metaR N2M2NMASNt
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: n2m2nmasn transport, Golgi to extracellular
type: Reaction

metaR APOC LYS BTNP
fast: false
is described by: ECO:0000000
reactant: MODEL1310110031#
name: proteolysis of apoC-Lys-btn
kinetic law: MODEL1310110031#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110031#

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#

metaR A4GALTg
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
product: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
is: SBO:0000176
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_16703bd9_c38f_4e47_8b1c_2b34837b5b00
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: CA5B
has only substance units: false
constant: false
initial concentration: NaN
is: Q9Y2D0
is encoded by: hsa:11238

metaR r0615
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110031#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#

metaM 3hexdcoa c
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: HMDB03932
is: C05258
boundary condition: false
initial amount: NaN
has only substance units: false
name: 3-hydroxyhexadecanoylcoa
constant: false

metaM HC02216 e
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
is: SBO:0000247
is: CHEBI:28922

metaR FAOXC226C225m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR PROt2r
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000304
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-proline reversible transport via proton symport
fast: false
product: MODEL1310110031#

metaR ST8SIA11
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e903ef86_b8ce_476c_973c_b963ba7c6462
name: FOLR1
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P15328
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252

metaR GLXtp
kinetic law: MODEL1310110031#
name: glyoxylate transport, peroxisomal
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true

metaR INOSTO
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.13.99.1
is described by: ECO:0000269
product: MODEL1310110031#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (55586.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 1.13.99.1 Confidence Level: 4 AUTHORS: PMID:15504367 NOTES:NCD
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#
name: inositol oxygenase

metaM hxcoa m
is: SBO:0000247
constant: false
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false

metaR r0614
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_136ad486_859c_4edb_b178_4a7efed6f5c5
initial amount: NaN
name: AMY2B
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:280
is: P19961
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6703ed4d_2a15_47d1_bc95_2c6da460d58f
is encoded by: hsa:1607
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DGKB

http://identifiers.org/biomodels.db/MODEL1310110031#_e996cbd1_efd9_4f52_91bf_c23413ecae57
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q15758
is encoded by: hsa:6510
boundary condition: true
initial concentration: NaN
type: Species
name: SLC1A5

metaR r0553
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a02aa25b_390e_434a_890b_d93a1cf88769
has part: Q8TF08
has part: P09669
type: Species
is encoded by: hsa:84701
is encoded by: hsa:341947
has part: Q6FGA0
has part: Q53YB7
is encoded by: hsa:1349
is encoded by: hsa:9167
has part: P15954
has part: P12074
has part: P14854
is encoded by: hsa:1350
is encoded by: hsa:4513
has part: Q7Z4L0
has part: P24311
has part: Q6YFQ2
initial amount: NaN
has part: P24310
has only substance units: false
is encoded by: hsa:1337
has part: Q7GXZ8
boundary condition: true
has part: P20674
has part: H0UI06
is encoded by: hsa:4512
is encoded by: hsa:1346
has part: P13073
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:9377
initial concentration: NaN
is encoded by: hsa:170712
is: SBO:0000297
has part: P00414
has part: Q53XN1
is encoded by: hsa:1340
has part: Q7GXY8
is encoded by: hsa:1345
is encoded by: hsa:1329
is encoded by: hsa:125965
has part: Q96KJ9
is encoded by: hsa:1339
constant: false
is encoded by: hsa:1347
is encoded by: hsa:1327
has part: Q02221
is encoded by: hsa:4514
is encoded by: hsa:1351

metaR NADPNe
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
is version of: http://identifiers.org/ec-code/3.2.2.5
is: SBO:0000176
type: Reaction
name: NADP nucleosidase,extracellular
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_acc9ead9_bf93_4124_afe6_80b135bda251
name: PHYH
is encoded by: hsa:5264
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O14832

metaM 5mthf c
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: HMDB01396
has only substance units: false
name: 5-Methyltetrahydrofolate
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: C00440
initial concentration: 1.0
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110031#_21614133_60d6_422b_8f16_c1e10aff8d49
is encoded by: hsa:8836
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GGH
has only substance units: false
constant: false
is: Q92820
type: Species
initial amount: NaN

metaR SCP21cx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM 2dr5p c
is: HMDB01031
has only substance units: false
initial amount: NaN
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57651
boundary condition: false

metaR VLCS2p
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_1c15b800_6f46_49e2_aacb_a7bbd1ae9d97
type: Species
is: P16442
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:28
name: ABO
initial amount: NaN
is: SBO:0000252
constant: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM 3ivcoa c
is: HMDB06870
name: 3-hydroxyisovalerylcoa
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
type: Species
is: C05998
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaR GALASE17ly
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
type: Reaction

metaR r0617
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110031#

metaM HC01223 m
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57340
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247

metaM gthox m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58297
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
boundary condition: false
is: SBO:0000247

metaR r0556
reversible: true
modifier: MODEL1310110031#
fast: false
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000
product: MODEL1310110031#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is: SBO:0000176

metaR THRGLNexR
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
type: Reaction
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_7e88b0ca_4a29_416f_ab6e_9b20a07b3c41
has only substance units: false
name: PDE10A
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10846
is: Q9Y233
boundary condition: true
constant: false

metaR RE1518M
name: RE1518
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
kinetic law: MODEL1310110031#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR NACHEX3ly
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

metaM L2aadp m
name: L-2-aminoadipate(1-)
type: Species
constant: false
is: CHEBI:58672
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: HMDB00510
is: SBO:0000247

metaM cs e l
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: SBO:0000247
constant: false
is: HMDB02183
is: CHEBI:36005
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_0946a264_46b2_4a99_beef_07ab96144756
initial concentration: NaN
name: GLO1
type: Species
is: Q04760
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2739

metaR UAGDP
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
name: UDP-N-acetylglucosamine diphosphorylase
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
type: Reaction
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.23
reversible: false
kinetic law: MODEL1310110031#

metaR r0559
modifier: MODEL1310110031#
is: SBO:0000176
fast: false
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaM digalside hs l
is: http://identifiers.org/pubchem.compound/8383
name: Digalactosylceramide
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
boundary condition: false
is: C06126
initial concentration: 1.0
type: Species
constant: false

metaR CYTK7n
name: cytidylate kinase (CMP,UTP),nuclear
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110031#

metaR FAOXC162C162OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM 3mlda c
is: C05828
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8122
boundary condition: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
constant: false
is: HMDB02820
has only substance units: false
type: Species
is: SBO:0000247
name: 3-Methylimidazoleacetic acid
initial amount: NaN

metaR DCSPTN1CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110031#
reversible: false
name: carnitine transferase
modifier: MODEL1310110031#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r0781
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is described by: ECO:0000000
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110031#_4506beb3_8bf7_4902_ad58_a46185c30173
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P34896
initial amount: NaN
is encoded by: hsa:6470
type: Species
name: SHMT1

metaM k e
is: C00238
boundary condition: false
has only substance units: false
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
type: Species
initial concentration: 1.0
is: CHEBI:29103
constant: false
is: SBO:0000247
initial amount: NaN

metaM prostgd2 e
name: prostaglandin D2(1-)
is: CHEBI:57406
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01403

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_bfc0f13d_c4b5_4716_a348_2d84be31cabb
is encoded by: hsa:55
boundary condition: true
has only substance units: false
is: P15309
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACPP
type: Species

metaR XOL27OHtm
fast: false
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

metaR r0782
is described by: ECO:0000000
product: MODEL1310110031#
fast: false
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:

metaM nad c
is: C00003
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:57540
is: HMDB00902
boundary condition: false

metaR DOLP Uter
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (uterus)
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_73dfdbb8_6cbb_40af_8efe_ad7b7ad82ccf
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
initial concentration: NaN
has part: A8K092
is: SBO:0000297
has part: P36542
is encoded by: hsa:498
boundary condition: true
has part: P56381
has part: P30049
is encoded by: hsa:514
is encoded by: hsa:513
is encoded by: hsa:509
has only substance units: false
is encoded by: hsa:506
has part: P06576
constant: false
initial amount: NaN

metaR P45027A15m
kinetic law: MODEL1310110031#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
is: SBO:0000176
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269

metaR PDE4n
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.35
modifier: MODEL1310110031#
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
reversible: false
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
type: Reaction

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR MALTSULtm
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
type: Reaction

metaR PIter
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
name: phosphate transport, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000212
fast: false

metaM acgal1p c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:55404
initial amount: NaN
constant: false
name: N-Acetyl-D-galactosamine 1-phosphate
is: HMDB06480
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_be452119_d3bb_465b_af66_c1cdc0780477
constant: false
boundary condition: true
is encoded by: hsa:22934
initial amount: NaN
has only substance units: false
name: RPIA
type: Species
initial concentration: NaN
is: SBO:0000252
is: P49247

metaR G6PDH1rer
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
product: MODEL1310110031#

metaR RE3628M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
modifier: MODEL1310110031#
name: RE3628
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_bd7ff399_ba82_491a_87a4_1f1d723e8714
is: P27986
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:5295
constant: false
name: PIK3R1
boundary condition: true

metaR NACHEX18ly
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

metaM xol7ah2 m
initial amount: NaN
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28047
is: HMDB06893

metaM HC01842 c
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:31997
is: SBO:0000247
name: Phosphodimethylethanolamine
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110031#_e2134cfb_8c63_4ce9_b421_0e0b9c5f9213
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6535
constant: false
has only substance units: false
name: SLC6A8
is: B4DIA3

metaM C02528 r
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
initial amount: NaN
is: CHEBI:36234
initial concentration: 1.0
is: HMDB00518
name: chenodeoxycholate
has only substance units: false

metaR HSD17B4x
is described by: ECO:0000269
reversible: false
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
name: hydroxysteroid (17-beta) dehydrogenase 4
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f6c8dde7_822b_4492_9033_e20fe2d04619
constant: false
type: Species
is encoded by: hsa:5294
name: PIK3CG
boundary condition: true
is: P48736
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r0558
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110031#
reversible: true

metaR 3AIBTm
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000304
modifier: MODEL1310110031#
name: L-3-aminoisobutyrate transaminase, mitochondrial
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r0780
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
type: Reaction
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false

metaM hdcoa c
is: HMDB06532
is: SBO:0000247
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false

metaR B3GALT5g
reversible: false
fast: false
kinetic law: MODEL1310110031#
name: Beta-1,3-galactosyltransferase 5
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#

metaM acglcgalgbside hs g
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: GlcNAc-Gal globoside
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: CHEBI:26174

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f8b154b3_1cbe_4a34_931b_6cc92173ec3c
boundary condition: true
is: SBO:0000252
constant: false
name: FASN
is: P49327
has only substance units: false
is encoded by: hsa:2194
initial concentration: NaN
initial amount: NaN
type: Species

metaM c10crn c
type: Species
initial concentration: 1.0
name: decanoyl carnitine
constant: false
notes: FORMULA: C17H33NO4 CHARGE: 0
is: HMDB00651
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM ocde9ecoa x
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: 9-octadecenoylcoa
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110031#_31b6faf5_9dca_4167_9f84_1b07567263ed
name: UGP2
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:7360
is: SBO:0000252

metaM 3ttetddcoacrn c
is: HMDB02014
boundary condition: false
initial amount: NaN
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H37NO5 CHARGE: 0
constant: false
initial concentration: 1.0

metaR CHLtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
name: choline transport via diffusion (cytosol to mitochondria)
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_f05a78a0_3154_48f4_b1b1_f5bbc6bc1c66
boundary condition: true
is encoded by: hsa:23396
is: O60331
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PIP5K1C
initial concentration: NaN
constant: false

metaM ksi pre33 g
is: HMDB00175
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58053
constant: false
is: C00130
type: Species
is: SBO:0000247
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 33
initial concentration: 1.0

metaM pail4p hs c
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false
is: CHEBI:58178
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
initial amount: NaN

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000176
reactant: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
type: Reaction
fast: false

metaM HC00900 c
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: Methylmalonate
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860

http://identifiers.org/biomodels.db/MODEL1310110031#_2a46d28d_59f1_4a5a_bbbb_0af6d0f2cc3e
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P17174
initial amount: NaN
is encoded by: hsa:2805
name: GOT1
has only substance units: false

metaM em2emgacpail prot hs r
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00618
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58121

http://identifiers.org/biomodels.db/MODEL1310110031#_13ae3dfd_2f7d_4d21_a6a8_a5810f3c91d0
is: SBO:0000252
name: ME2
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4200
is: P23368
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_97408f2c_0d4d_4d92_aeac_ab537eb3f2f1
is encoded by: hsa:27010
is: F5GZG6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: TPK1
type: Species

metaM rib D e
is: SBO:0000247
type: Species
is: CHEBI:16988
has only substance units: false
is: HMDB00283
constant: false
name: D-ribose
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0

metaM n2m2mn l
initial amount: NaN
has only substance units: false
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
initial concentration: 1.0
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: CHEBI:36655
is: HMDB00119
boundary condition: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_f4fb1f8c_449f_4e8a_9c94_5888f1f9c971
is encoded by: hsa:2645
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: GCK
has only substance units: false
is: Q53Y25
boundary condition: true

metaM q10 e
initial concentration: 1.0
initial amount: NaN
name: ubiquinone-10
boundary condition: false
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false
is: CHEBI:46245
is: HMDB01072
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f5e42b1f_8dc5_4e32_b4a1_642953451a4f
is encoded by: hsa:270
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P23109
boundary condition: true
type: Species
name: AMPD1
constant: false
initial amount: NaN

metaR TSTSTERONESULT
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.14
fast: false
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: testosterone sulfotransferase
is: SBO:0000176
product: MODEL1310110031#
reversible: false

metaR r2140
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_adb39a0e_78ad_4c6e_9e63_8eeede7a7853
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53354
initial concentration: NaN
name: PANK1
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaM 2hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
constant: false
is: HMDB02288

metaM L2aadp c
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
is: HMDB00510
name: L-2-aminoadipate(1-)
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58672
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM cala c
type: Species
is: CHEBI:11892
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial amount: NaN
boundary condition: false
is: HMDB00026
is: SBO:0000247
initial concentration: 1.0
constant: false
name: N-carbamoyl-beta-alaninate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a0130676_fc46_4daa_8094_b8f461b745a2
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:10449
is: SBO:0000252
name: ACAA2
constant: false
has only substance units: false
is: P42765
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_b0325f27_4b45_4dbd_96d3_a55ca0a639b1
initial amount: NaN
is encoded by: hsa:3284
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P26439
name: HSD3B2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b42e8791_7808_4a4e_a54a_31218298247e
name: _642502_1_c
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:642502

http://identifiers.org/biomodels.db/MODEL1310110031#_61e91c73_a489_49ba_ab24_9a424724279e
is encoded by: hsa:2181
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: B3KMA6
name: ACSL3
initial concentration: NaN
has only substance units: false

metaM ha pre1 e
has only substance units: false
is: CHEBI:16126
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
constant: false
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_af973f75_5d7a_4c7b_8d10_d0dabdd252e1
is: Q13423
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23530
name: NNT
type: Species
has only substance units: false
initial amount: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR CH25H
name: cholesterol 25-hydroxylase
kinetic law: MODEL1310110031#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.99.38
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110031#

metaM HC00342 m
is: CHEBI:16383
name: cis-aconitate(3-)
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r0783
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is: SBO:0000176
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
type: Reaction
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r0408
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
type: Reaction
is described by: ECO:0000000
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR ATPS4m
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.14
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.4.6
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.14
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
name: ATP synthase (four protons for one ATP)
is described by: ECO:0000134

metaM 3ttetddcoacrn e
boundary condition: false
is: SBO:0000247
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
has only substance units: false
type: Species
constant: false
notes: FORMULA: C21H37NO5 CHARGE: 0
is: HMDB02014
initial concentration: 1.0
initial amount: NaN

metaR IDOURte
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000134
fast: false
name: L-iduronate transport, extracellular
reactant: MODEL1310110031#

metaM vacc e
name: trans-vaccenate
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial amount: NaN
is: CHEBI:30828
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0587bcdb_5923_4e55_b6f3_c0de6cba4cc4
is encoded by: hsa:4712
is: O95139
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFB6
initial amount: NaN

metaM k c
is: HMDB00586
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29103
is: C00238
type: Species
has only substance units: false

metaM 2mb2coa m
is: SBO:0000247
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
initial amount: NaN
constant: false
name: 2-methylcrotonoyl-CoA(4-)
type: Species
is: CHEBI:57337
has only substance units: false
boundary condition: false

metaM cysam c
boundary condition: false
name: cysteaminium
is: SBO:0000247
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
is: HMDB02991
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaM tsul c
initial concentration: 1.0
boundary condition: false
is: CHEBI:16094
has only substance units: false
name: thiosulfate(2-)
is: SBO:0000247
is: HMDB00257
constant: false
initial amount: NaN
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaM q10 c
initial concentration: 1.0
name: ubiquinone-10
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
is: HMDB01072
constant: false
has only substance units: false
is: SBO:0000247

metaM ac e
has only substance units: false
name: acetate
initial amount: NaN
boundary condition: false
is: HMDB00042
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:30089
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR DCSPTN1CPT1
is described by: ECO:0000269
fast: false
modifier: MODEL1310110031#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM nad e
is: SBO:0000247
boundary condition: false
name: NAD(1-)
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57540
initial concentration: 1.0
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

metaM 2docohexecoa m
name: 2,7,10,13,16,19-docosahexenoylcoa
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR r0784
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

metaR FAOXC16C16OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaM rib D c
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16988
is: HMDB00283
name: D-ribose
constant: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_a239a0c1_d026_4e6e_9285_8fc87187034b
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: ENTPD1
is: SBO:0000252
is encoded by: hsa:953
is: Q86VV3
boundary condition: true

metaR G16MT L
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e7b15860_6cfc_482a_b6dd_6e07b974c407
is encoded by: hsa:2982
constant: false
is: SBO:0000297
type: Species
initial amount: NaN
initial concentration: NaN
name: GUCY1B2:GUCY1A3
has part: D6RDW3
boundary condition: true
is encoded by: hsa:2974
has only substance units: false

metaR DIDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
name: dIDP nuclear transport
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_1159e9c3_a82b_44b8_9843_16f8dba8df93
is: Q546E0
constant: false
name: FUT8
has only substance units: false
type: Species
is encoded by: hsa:2530
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM 3mldz c
boundary condition: false
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
constant: false
is: CHEBI:28104
is: HMDB04181
type: Species
name: 1-methylimidazole-4-acetaldehyde
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR DOLASNT Ler
is version of: http://identifiers.org/ec-code/2.4.1.119
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
is: SBO:0000176
product: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_167cee26_15b8_446a_9a0e_df66c478656c
constant: false
name: ACAA2
is encoded by: hsa:10449
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: P42765

metaR ACACtx
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
name: acetoacetate intracellular transport unknown mechanism

http://identifiers.org/biomodels.db/MODEL1310110031#_bec92c4c_5d15_48cf_9e37_b10a7e744ea8
is: Q75T13
has only substance units: false
boundary condition: true
initial amount: NaN
name: PGAP1
is: SBO:0000252
type: Species
is encoded by: hsa:80055
constant: false
initial concentration: NaN

metaM xol7ah2 c
boundary condition: false
is: CHEBI:28047
is: HMDB06893
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_fbdd1f6e_268c_459f_aa65_1136ca1565f4
boundary condition: true
name: SLC38A1
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: Q9H2H9
is: SBO:0000252
is encoded by: hsa:81539
initial amount: NaN

metaR S2TASE2ly
name: iduronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR r2369
reactant: MODEL1310110031#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR NDPK3
product: MODEL1310110031#
name: nucleoside-diphosphate kinase (ATP:CDP)
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_82c33353_3f31_490a_bd44_5d504335e516
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: B7Z5T8
initial concentration: NaN
boundary condition: true
has only substance units: false
name: CPT1B
is encoded by: hsa:1375

metaR GLACter
fast: false
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_a6b7b4eb_250e_4947_856c_fa16b97db1ff
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:122622
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ADSSL1
constant: false
is: B3KTV4

metaM 2mb2coa c
initial concentration: 1.0
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR NDPK4
kinetic law: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110031#
name: nucleoside-diphosphate kinase (ATP:dTDP)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_49ea08bc_088b_476e_bf8e_cf64ed2cb5eb
constant: false
is: C9JZ62
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:641649
boundary condition: true
name: TMEM91

metaM ura e
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
type: Species
is: HMDB00300
name: uracil
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:17568
is: SBO:0000247
has only substance units: false

metaM CE5853 e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
constant: false
name: alpha-CEHC-glucuronide

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR r1900
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR LNLNCGt
kinetic law: MODEL1310110031#
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_5e880113_09bb_4b2f_a780_e744edeac67b
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:29926
has only substance units: false
name: GMPPA
boundary condition: true
constant: false
initial amount: NaN
is: Q96IJ6

metaM mercplaccys c
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: 3-mercaptolactate-cysteine disulfide
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06512

metaM 3mb2coa m
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
name: 3-methylbut-2-enoyl-CoA(4-)
is: HMDB01493
type: Species
boundary condition: false
is: CHEBI:57344
constant: false
initial concentration: 1.0

metaR NDPK2
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110031#
name: nucleoside-diphosphate kinase (ATP:UDP)
product: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06532
has only substance units: false
boundary condition: false
type: Species

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_fe7af3c3_c8d7_43b6_a861_62fd81d49437
constant: false
boundary condition: true
is: B2RB13
name: ACSL6
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:23305

metaR r0407
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110031#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is: SBO:0000176
modifier: MODEL1310110031#

metaM 34dhmald c
boundary condition: false
constant: false
is: C05577
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB06242

metaM ac c
is: HMDB00042
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: SBO:0000247
is: CHEBI:30089
has only substance units: false
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110031#_ebfd30a0_5691_4c19_a226_cd265307da93
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: AK4
is: SBO:0000252
is: P27144
is encoded by: hsa:205
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0f082326_1965_4974_ae76_fbcc715d20b5
initial concentration: NaN
is: Q59F77
boundary condition: true
initial amount: NaN
name: PLCB2
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5330

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR FATP9t
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.7
name: fatty acid electroneutral transport
is: SBO:0000185
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

metaR ABO5g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
product: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#

metaR r2367
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110031#
type: Reaction
fast: false
product: MODEL1310110031#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaR NDPK1
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000134
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP)

http://identifiers.org/biomodels.db/MODEL1310110031#_29ee93da_0c56_450b_a5eb_aff3a98f4e42
constant: false
is: SBO:0000252
name: PRDX2
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7001
boundary condition: true
has only substance units: false

metaM ura c
is: SBO:0000247
name: Uracil
type: Species
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
is: C00106
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:17568

metaR r2141
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM gcald c
constant: false
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
boundary condition: false
initial amount: NaN
type: Species
is: HMDB03344
initial concentration: 1.0
name: glycolaldehyde
is: CHEBI:17071
has only substance units: false

metaM gullac c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial amount: NaN
is: HMDB03466
initial concentration: 1.0
is: CHEBI:17587
name: L-gulono-1,4-lactone
has only substance units: false

metaM HC02023 r
boundary condition: false
type: Species
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: CHEBI:46898
is: SBO:0000247
name: Cholesterol-ester-ol
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_2bb8b58d_1a90_42ee_b783_515070d23c3b
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:515
name: ATP5F1
constant: false

metaR r2368
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM dolmanp U r
has only substance units: false
type: Species
is: CHEBI:15809
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human uterine homolog
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
is: HMDB01866
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:27637
initial amount: NaN
is: SBO:0000247
constant: false

metaM dolglcp L c
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial concentration: 1.0
has only substance units: false
is: CHEBI:15812

metaR r2142
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: true

metaM pglyc hs c
notes: FORMULA: CHARGE: 0
constant: false
is: HMDB02704
is: CHEBI:21338
name: pglyc_hs[c]
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM hxcoa x
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00705
constant: false
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
boundary condition: false

metaR MDHm
is: SBO:0000176
reversible: true
name: malate dehydrogenase, mitochondrial
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.37
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_2fece360_5196_4402_bb3e_e4c0c346c97a
name: ALDH1A2
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8854
initial amount: NaN
is: O94788

http://identifiers.org/biomodels.db/MODEL1310110031#_f762e786_c37d_498b_bb47_1b6bfe660ee5
has only substance units: false
type: Species
constant: false
is: Q8WY07
boundary condition: true
name: SLC7A3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84889

http://identifiers.org/biomodels.db/MODEL1310110031#_7a911cdd_2950_424a_b4a3_78c1b7ef0457
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR EX 3octdeccrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_4eb8def4_8f31_47e2_87fe_aa8c770bc6a3
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2717
name: GLA
type: Species
constant: false
initial concentration: NaN
is: Q53Y83

metaR FAOXC61m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR EX 3hdececrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaM ksi pre18 g
initial concentration: 1.0
is: C00130
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 18
boundary condition: false
is: HMDB00175
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
type: Species
has only substance units: false
is: CHEBI:58053
is: SBO:0000247

metaM udpglcur c
is: CHEBI:58052
is: C00167
type: Species
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
name: UDP-D-glucuronate
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00935
initial concentration: 1.0

metaR GGH 7DHFe
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110031#
fast: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
reversible: false

metaM prostgd2 r
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: prostaglandin D2(1-)
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
has only substance units: false
type: Species
is: HMDB01403

http://identifiers.org/biomodels.db/MODEL1310110031#_bb802b71_a17f_4bec_92da_11cfcc3bc06e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P33121
initial amount: NaN
type: Species
is encoded by: hsa:2180
is: SBO:0000252
name: ACSL1
constant: false

metaM itaccoa m
boundary condition: false
is: HMDB03377
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: SBO:0000247
name: itaconyl-CoA(5-)
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57381
has only substance units: false

metaR LACZe
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
fast: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.108
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: b-galactosidase, extracellular
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_d0203bc1_1b12_452e_a21c_388bdfa4f62e
name: ADH5
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:128
type: Species
constant: false
initial amount: NaN
is: Q6IRT1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_cc4f8ef0_756d_4000_93f9_4f9adf1cfb24
name: MTHFD1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:4522
initial amount: NaN
constant: false
is: P11586
initial concentration: NaN

metaR NICRNS
is: SBO:0000176
reactant: MODEL1310110031#
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
product: MODEL1310110031#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110031#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_dfcbea65_d314_447c_b4cf_cd7270124a59
has only substance units: false
name: SLC2A13
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:114134
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q96QE2

http://identifiers.org/biomodels.db/MODEL1310110031#_42f1ddbf_8c8d_4e27_b82f_b3cbc93fb30e
has only substance units: false
is encoded by: hsa:159963
type: Species
name: SLC5A12
is: Q1EHB4
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR RDH3a
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110031#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (11-cis,NADPH)
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_08c32c29_c89b_4632_bd2e_a05fc8fe3dee
type: Species
is encoded by: hsa:2184
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: FAH
is: P16930
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_d5357439_59e0_44ac_b560_e33c9b17c3c3
has only substance units: false
is: Q9Y673
initial amount: NaN
initial concentration: NaN
name: ALG5
is: SBO:0000252
is encoded by: hsa:29880
constant: false
boundary condition: true
type: Species

metaR r0403
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110031#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4

metaR r1088
name: Active transport
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#

metaM thbpt4acam c
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0

metaM hedepecoa m
initial amount: NaN
name: 2,4,7,10,13-hexadecapentenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02288
type: Species
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110031#_1a5cb595_c694_4fc4_ac13_fd211b53a090
is: Q08828
is encoded by: hsa:107
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: ADCY1
type: Species
initial concentration: NaN

metaM ha pre1 l
is: SBO:0000247
is: CHEBI:16126
constant: false
has only substance units: false
initial amount: NaN
name: hyaluronan biosynthesis, precursor 1
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1

metaM 2hexdtricoa x
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
name: 2,7,10-hexadecatrienoylcoa
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM dctp n
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
is: HMDB00998
is: CHEBI:16311
boundary condition: false
is: C00458
type: Species
is: SBO:0000247
name: dCTP

http://identifiers.org/biomodels.db/MODEL1310110031#_965d97fc_6756_4b79_a8a6_cb698d7b5a08
initial amount: NaN
constant: false
boundary condition: true
is: P18283
initial concentration: NaN
name: GPX2
is encoded by: hsa:2877
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_a329238f_2f6b_455e_8873_6dbf23dda206
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC8A3
has only substance units: false
initial amount: NaN
is encoded by: hsa:6547
is: Q96QG2
constant: false

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_8027273b_32ca_4e9e_b6c3_6bd5881c00e3
is: P30837
has only substance units: false
is: SBO:0000252
is encoded by: hsa:219
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDH1B1
type: Species
constant: false

metaM 3mlda e
initial amount: NaN
is: HMDB02820
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: C05828
boundary condition: false
name: 3-Methylimidazoleacetic acid
is: http://identifiers.org/pubchem.compound/8122
is: SBO:0000247

metaM 3decdicoa x
name: 3,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaM 4hbz m
boundary condition: false
is: HMDB00500
is: SBO:0000247
constant: false
is: CHEBI:17879
initial amount: NaN
name: 4-hydroxybenzoate
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_4de02018_b78c_4c0c_8c06_c2922820868e
initial concentration: NaN
name: _AA177072_1_x
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA177072
has only substance units: false
type: Species

metaR FAOXC142C142OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_302cee33_389e_459b_9348_032a4407bdaf
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7166
name: TPH1
is: P17752

metaR FAOXC13C11m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

metaR RE0689E
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0689
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction

metaM mercplaccys e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-mercaptolactate-cysteine disulfide
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
type: Species
has only substance units: false

metaR ARGtiDF
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: L-arginine transport via diffusion (extracellular to cytosol)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110031#
fast: false
is: SBO:0000185
modifier: MODEL1310110031#

metaR G16MT U
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
reactant: MODEL1310110031#

metaR ASCBt
product: MODEL1310110031#
type: Reaction
name: L-ascorbate transport via facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR 2HBt2
type: Reaction
name: 2-hydroxybutyrate cotransport with proton
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
product: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000269

metaR C6COAt
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR r2362
is described by: ECO:0000000
product: MODEL1310110031#
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM CE1940 e
is: HMDB02329
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
initial amount: NaN
is: CHEBI:30623
type: Species
initial concentration: 1.0
name: spermidine monoaldehyde 2

metaM 34dhoxmand m
is: SBO:0000247
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
constant: false

metaR GULN3D
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
name: L-gulonate 3-dehydrogenase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
is described by: ECO:0000000

metaR B3GNT312g
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110031#
reversible: false
is described by: ECO:0000254
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_afd2088f_c887_423e_bf3c_dd07dbcc1d44
name: SLC25A18
constant: false
is encoded by: hsa:83733
is: Q9H1K4
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR C226CPT2
modifier: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
name: C226 transport into the mitochondria
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV

metaR ADPACDAc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_a9745656_fba0_47d1_acea_12a97bc8a5e2
constant: false
boundary condition: true
initial concentration: NaN
name: TRNT1
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q96Q11
is encoded by: hsa:51095

metaR GLCter
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: glucose transport, endoplasmic reticulum

metaM dgdp c
name: dGDP
has only substance units: false
constant: false
is: HMDB00960
initial amount: NaN
boundary condition: false
is: CHEBI:58595
initial concentration: 1.0
is: C00361
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM 4hoxpacd c
constant: false
name: (4-hydroxyphenyl)acetaldehyde
has only substance units: false
is: HMDB03767
is: SBO:0000247
is: CHEBI:15621
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
type: Species

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
type: Reaction
reversible: true
is: SBO:0000185

metaM HC00342 c
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
initial amount: NaN
has only substance units: false
name: cis-aconitate(3-)
initial concentration: 1.0

metaR r1908
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR r0410
reversible: true
is: SBO:0000176
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
initial amount: NaN
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C03838
type: Species
is: CHEBI:58457

http://identifiers.org/biomodels.db/MODEL1310110031#_8ff58833_7390_4055_8647_c861fa00ed43
is: SBO:0000252
name: _AW299740_1_m
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AW299740
constant: false

metaR DCSPTN1CRNt
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#
is: SBO:0000185
reversible: false
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110031#

metaM ksi pre9 g
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 9
type: Species
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
initial concentration: 1.0
is: C00130
constant: false
is: HMDB00175
boundary condition: false

metaR C226CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110031#
type: Reaction
reversible: false
modifier: MODEL1310110031#
name: carnitine C22:6 transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#

metaM 34dhmald m
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: 3,4-Dihydroxymandelaldehyde
boundary condition: false
initial concentration: 1.0

metaM tsul m
initial concentration: 1.0
is: CHEBI:16094
has only substance units: false
is: SBO:0000247
boundary condition: false
name: thiosulfate(2-)
is: HMDB00257
type: Species
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_02e5480f_6c4d_4dd5_83d0_9d02ffa1ec61
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: AK2
is encoded by: hsa:204

metaM ascb L e
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: L-ascorbate
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: CHEBI:38290
type: Species
initial amount: NaN
is: HMDB00044

metaM c226coa m
name: cervonyl coenzyme A
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR r2360
reversible: true
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110031#

metaM HC00900 m
is: CHEBI:30860
type: Species
boundary condition: false
constant: false
name: Methylmalonate
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM dadp n
type: Species
initial concentration: 1.0
constant: false
is: HMDB01508
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
boundary condition: false
name: dADP(3-)
initial amount: NaN
has only substance units: false

metaR RE3241R
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
name: RE3241

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: CHEBI:59905
is: SBO:0000247
initial amount: NaN
name: dopaminium(1+)
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00073

metaM c8crn c
type: Species
is: HMDB00791
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
boundary condition: false
has only substance units: false
name: octanoyl carnitine
is: C02838
is: SBO:0000247

metaR FACOAL180i
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
name: C180 fatty acid activation
reactant: MODEL1310110031#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110031#
is: SBO:0000176

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
fast: false

metaR SGPL12r
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
name: Sphingosine-1-phosphate lyase
is described by: ECO:0000304
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction

metaR DDECCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaM ptdca e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00826
name: pentadecanoate
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: SBO:0000247

metaM ksi pre6 g
is: C00130
type: Species
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 6
initial amount: NaN
constant: false
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C107H174N7O80SX CHARGE: -2

metaR r1906
type: Reaction
product: MODEL1310110031#
reversible: false
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0331
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
type: Reaction

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110031#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_10f89445_76f3_422b_b60e_d569a5427176
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AI378339_1_m
is encoded by: hsa:AI378339
initial amount: NaN
type: Species

metaR 3SALATAim
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
type: Reaction
reversible: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4b45500d_dfde_4191_83fc_d561feb3c389
has only substance units: false
name: PIGF
is: Q07326
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:5281
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110031#_9400cd52_ed95_4b6a_8789_bca3d960b2bc
is encoded by: hsa:D29675
boundary condition: true
constant: false
name: _D29675_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM c5dc c
initial amount: NaN
name: glutaryl carnitine
notes: FORMULA: C12H21NO6 CHARGE: 0
is: SBO:0000247
is: HMDB13130
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaM cs e deg5 l
type: Species
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: HMDB00868
initial concentration: 1.0
has only substance units: false

metaR RPI
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
modifier: MODEL1310110031#
name: ribose-5-phosphate isomerase
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110031#_96746a45_492c_4368_a9f6_ed5f65fbaba9
constant: false
name: _AA664770_1_m
type: Species
initial concentration: NaN
is encoded by: hsa:AA664770
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM nad r
is: CHEBI:57540
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00902
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
name: NAD(1-)

metaM m5mpdol L r
is: CHEBI:37634
is: SBO:0000247
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_0b7f22d5_718d_4941_92da_c482e9bd20a2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q16878
constant: false
name: CDO1
has only substance units: false
is encoded by: hsa:1036

metaM c8crn e
name: octanoyl carnitine
type: Species
has only substance units: false
initial concentration: 1.0
is: C02838
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00791
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0

metaM datp n
type: Species
is: C00131
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
is: SBO:0000247
name: dATP
initial amount: NaN
initial concentration: 1.0
is: HMDB01532
boundary condition: false

metaM ascb L c
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: L-ascorbate
is: CHEBI:38290
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
initial amount: NaN

metaM nad x
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide
type: Species
is: CHEBI:57540
initial concentration: 1.0
boundary condition: false
is: HMDB00902
is: C00003

metaR r2366
fast: false
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM m5mpdol U r
constant: false
is: CHEBI:37634
boundary condition: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110031#_cdda048f_7ec4_4318_8617_75c7acd1f88f
name: HSD3B1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3283
has only substance units: false
type: Species
is: P14060

metaM ptdca c
name: pentadecanoate
initial amount: NaN
constant: false
type: Species
is: HMDB00826
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/22169126
initial concentration: 1.0
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaM h2o2 c
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
is: C00027
constant: false
initial concentration: 1.0
is: HMDB03125
initial amount: NaN
has only substance units: false
type: Species
name: Hydrogen peroxide
is: SBO:0000247
boundary condition: false

metaM cspg e e
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: C00106
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: HMDB00300
is: CHEBI:17568
has only substance units: false
constant: false

metaR r0560
reversible: false
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
kinetic law: MODEL1310110031#

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM HC01409 m
is: CHEBI:27540
has only substance units: false
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
initial concentration: 1.0
name: Hexanoyl-CoA
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR FAOXC103C102m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR C160CPT1
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
name: production of Palmitoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_9b25d31f_74ad_48e8_9d5c_2c150441fcb2
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:T83654
is: SBO:0000252
name: _T83654_1_e
constant: false

metaM fgam c
constant: false
is: HMDB01308
is: SBO:0000247
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
has only substance units: false
is: C04376

metaR r2365
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: true
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR AMETt2m
reversible: true
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is described by: ECO:0000269
modifier: MODEL1310110031#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e8139e90_ccb2_4faf_83eb_1bb21ff1c4ac
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM duri c
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
type: Species
is: CHEBI:16450
is: HMDB00012
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Deoxyuridine
constant: false
is: C00526

metaM trp L e
name: L-tryptophan
is: SBO:0000247
is: CHEBI:16828
is: HMDB00929
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
initial amount: NaN

metaM HC01118 r
is: SBO:0000247
name: presqualene diphosphate(3-)
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial amount: NaN
is: CHEBI:57310
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaM 2dp6mep m
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
constant: false
type: Species
initial amount: NaN
name: 2-Decaprenyl-6-methoxyphenol
boundary condition: false
is: CHEBI:50774
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR ACETONEt2
kinetic law: MODEL1310110031#
name: acetone transport via proton symport
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000185
modifier: MODEL1310110031#
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaR ABO6g
is described by: ECO:0000269
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false

metaM c5dc e
is: HMDB13130
initial amount: NaN
has only substance units: false
name: glutaryl carnitine
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_6f86e6da_1425_47a4_bf2a_f6a9e700fcb0
type: Species
is: SBO:0000252
has only substance units: false
is: Q71UM8
initial amount: NaN
name: ADCY2
is encoded by: hsa:108
boundary condition: true
constant: false
initial concentration: NaN

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110031#

metaR C160CPT2
reversible: false
is: SBO:0000176
product: MODEL1310110031#
is described by: ECO:0000269
name: C160 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_0e252ecd_4915_4bf7_95f0_6d1b1d388dce
has only substance units: false
name: LDHC
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:3948
constant: false
initial concentration: NaN
is: P07864
is: SBO:0000252

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: acryloyl-CoA(4-)
is: CHEBI:57367
initial amount: NaN
is: HMDB02307

metaM h2o2 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
boundary condition: false
name: hydrogen peroxide
constant: false
is: HMDB03125
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_ff4df269_9152_4a38_979d_9f61672cb386
boundary condition: true
name: _AU149534_1_m
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AU149534
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ec9b859c_06b0_4082_9693_9ad780f10730
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q99624
constant: false
name: SLC38A3
boundary condition: true
is encoded by: hsa:10991
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_55ca240a_0f06_4a4a_a3cc_2e10a1b5afb3
initial amount: NaN
type: Species
has only substance units: false
name: PTS
is: SBO:0000252
is: Q03393
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5805

metaR EX c16dc
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaR S6T18g
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
type: Reaction
reactant: MODEL1310110031#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21

http://identifiers.org/biomodels.db/MODEL1310110031#_47007802_d8fc_4944_9c1b_61c2874e5e26
is: Q08ET0
is: SBO:0000252
initial concentration: NaN
name: ATP5F1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:515
constant: false
type: Species

metaR r2363
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110031#

metaR PDX5PO
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
modifier: MODEL1310110031#
type: Reaction
name: pyridoxine 5'-phosphate oxidase
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_c601a3e0_2f92_4ce8_af09_c4722bf8529c
is encoded by: hsa:5168
is: Q13822
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ENPP2
type: Species
initial amount: NaN

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
fast: false
kinetic law: MODEL1310110031#

metaM ptth m
initial concentration: 1.0
type: Species
boundary condition: false
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
initial amount: NaN
constant: false
is: HMDB03426
is: CHEBI:16753
is: SBO:0000247

metaM duri e
constant: false
is: C00526
is: CHEBI:16450
has only substance units: false
initial concentration: 1.0
is: HMDB00012
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM 2dodtricoa m
type: Species
name: 2,6,9-dodecatrienoylcoa
initial concentration: 1.0
initial amount: NaN
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
is: HMDB11123
boundary condition: false
constant: false

metaR PEROXx
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110031#
name: peroxisomal lumped long chain fatty acid oxidation
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

metaR RPE
reactant: MODEL1310110031#
name: ribulose 5-phosphate 3-epimerase
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_1273d883_109b_4935_ac26_753eb062b4d0
is: O43772
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC25A20
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:788

http://identifiers.org/biomodels.db/MODEL1310110031#_0d32333e_d5bc_489b_b101_06ef6faa904f
constant: false
is: SBO:0000252
is: Q93099
type: Species
is encoded by: hsa:3081
has only substance units: false
boundary condition: true
initial concentration: NaN
name: HGD
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_a9cd63fd_84c7_490c_82d6_ec6239af7f0b
type: Species
initial amount: NaN
is encoded by: hsa:2651
constant: false
name: GCNT2
is: Q08M29
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM dha e
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial concentration: 1.0
is: CHEBI:16016
is: HMDB01882
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: glycerone

http://identifiers.org/biomodels.db/MODEL1310110031#_286e71ce_89a7_4829_93ea_0d8a4ebbc2e9
initial concentration: NaN
constant: false
name: B3GALT5
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10317
boundary condition: true

metaR PROSTGI2tr
kinetic law: MODEL1310110031#
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_9e006dc9_7a9a_4c20_a971_5da573bf2800
boundary condition: true
is: SBO:0000252
name: B3GNT2
is encoded by: hsa:10678
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR S6TASE15ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
reversible: true
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174
name: I-antigen
has only substance units: false

metaR C10DCc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR PI4P3K
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
reversible: false
name: phosphatidylinositol 4-phosphate 3-kinase
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110031#_75c55451_3dd7_48b3_ae62_563e3a360215
initial concentration: NaN
type: Species
constant: false
is: P23786
initial amount: NaN
boundary condition: true
is encoded by: hsa:1376
name: CPT2
has only substance units: false
is: SBO:0000252

metaR GLNSERNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#

metaR RE2269E
name: RE2269
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaM HC01162 c
has only substance units: false
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial amount: NaN
constant: false
is: CHEBI:58376
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR FAOXC141C141OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR r1090
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
reversible: false

metaM dctp c
is: CHEBI:16311
type: Species
is: HMDB00998
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
name: dCTP

metaR FAOXC10C10OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR PALFATPtc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM 2dodtricoa x
is: HMDB11123
initial concentration: 1.0
type: Species
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C05279

http://identifiers.org/biomodels.db/MODEL1310110031#_4fb8a3bf_4495_4b30_8831_b96a368509c7
type: Species
initial concentration: NaN
has only substance units: false
is: G3V0F6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8525
name: DGKZ
initial amount: NaN
constant: false

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110031#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_1d287585_ccff_4ae3_a201_463184bba161
has only substance units: false
initial amount: NaN
name: SLC7A8:SLC3A2
type: Species
is encoded by: hsa:23428
has part: Q86U05
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000297

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR FUT16g
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000269
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.69
kinetic law: MODEL1310110031#
name: Galactoside 2-alpha-L-fucosyltransferase 1
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bd395b7a_5b21_4a6e_ad28_d76c8774228b
is: Q13232
boundary condition: true
is: SBO:0000252
name: NME3
type: Species
initial concentration: NaN
is encoded by: hsa:4832
has only substance units: false
initial amount: NaN
constant: false

metaM trp L c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
is: CHEBI:16828

metaR HOCTDACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR DHAPtc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110031#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110031#
name: transport of DHAP into cytosol
product: MODEL1310110031#
fast: false
type: Reaction
is described by: ECO:0000134

metaR EICOSTETCRNt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110031#
name: transport into the mitochondria (carnitine)
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_65a51554_7725_44bc_8611_48fa7777a9c4
is encoded by: hsa:4967
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: OGDH
is: Q02218
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaM datp m
is: C00131
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
type: Species
is: CHEBI:61404
constant: false
name: dATP
has only substance units: false
is: HMDB01532
initial concentration: 1.0
initial amount: NaN

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_3db752c0_63f4_4ce5_b414_aac720e57b4c
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51
is: SBO:0000252
name: ACOX1
constant: false
boundary condition: true
type: Species
is: Q15067

metaR NACHEX23ly
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal

metaR ABUTt2r
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
product: MODEL1310110031#
name: 4-aminobutyrate reversible transport in via proton symport
reversible: true
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a5dba736_fcce_4280_bcd3_07c6dd8e08b6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54344
constant: false
has only substance units: false
type: Species
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
boundary condition: true
has part: O60762
is encoded by: hsa:8813
has part: Q86TM7
has part: O94777
is: SBO:0000297

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_ef3e892f_efb1_435c_b140_50d9a5409b8e
is: SBO:0000252
constant: false
is: B3KWF4
boundary condition: true
is encoded by: hsa:63917
type: Species
initial concentration: NaN
name: GALNT11
has only substance units: false
initial amount: NaN

metaM ksi pre13 g
is: C00130
is: CHEBI:58053
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
constant: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species

metaR S6TASE9ly
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR PTPATe
is: SBO:0000176
name: PTPATe
fast: false
reversible: true
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000134
product: MODEL1310110031#
type: Reaction

metaR PA HStn
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#
name: phosphatidate transport, nuclear
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false

metaM gluala e
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB06248
is: C03740
boundary condition: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine

metaM c10crn e
initial amount: NaN
boundary condition: false
is: HMDB00651
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C17H33NO4 CHARGE: 0
name: decanoyl carnitine

metaR OMHPALTD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM HC00718 c
initial concentration: 1.0
initial amount: NaN
name: N-methylethanolaminium phosphate(1-)
constant: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

metaR r0899
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110031#

metaM lnlnca e
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01388
name: alpha-linolenate
constant: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
initial amount: NaN

metaR r0629
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
kinetic law: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65

metaM dopa e
name: dopaminium(1+)
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
has only substance units: false
is: CHEBI:59905
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00073
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_17278d97_f87f_4147_8876_9a63d4cfb80f
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: DPAGT1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1798
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1783b4de_6b9d_49fe_9d02_ea44bd3791c5
is: P30038
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: ALDH4A1
has only substance units: false
is encoded by: hsa:8659

http://identifiers.org/biomodels.db/MODEL1310110031#_c3a10155_5269_4f33_9048_7ae453ffa20d
has only substance units: false
type: Species
is encoded by: hsa:57134
initial concentration: NaN
name: MAN1C1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9NR34

http://identifiers.org/biomodels.db/MODEL1310110031#_66e9d21c_9f61_4d42_bc74_5e3f3d13a473
initial concentration: NaN
is: Q6YFQ2
is encoded by: hsa:125965
has only substance units: false
initial amount: NaN
constant: false
name: COX6B2
type: Species
boundary condition: true
is: SBO:0000252

metaM doco13ac e
has only substance units: false
constant: false
is: HMDB02068
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C22H41O2 CHARGE: -1
name: docosenoic acid (C22:1)

http://identifiers.org/biomodels.db/MODEL1310110031#_104fb00e_d6c6_44b1_a258_2c374346d274
is encoded by: hsa:NM 013421
initial concentration: NaN
boundary condition: true
name: _NM_013421_1_m
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR HOMt4
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110031#
is described by: ECO:0000269
name: L-homoserine via sodium symport
fast: false
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
reversible: false

metaM CE5160 r
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57923
name: 3-oxo-cis-9-octadecenoyl-CoA
constant: false
is: SBO:0000247

metaM dadp m
boundary condition: false
is: CHEBI:57667
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
type: Species
constant: false
is: HMDB01508
name: dADP(3-)

metaM cholate e
is: CHEBI:29747
name: Cholate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB00619
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN

metaR 34HPPte
type: Reaction
fast: false
is: SBO:0000185
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reactant: MODEL1310110031#
is described by: ECO:0000134
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FUT99g
is: SBO:0000176
name: Alpha-(1,3)-fucosyltransferase
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.152
reversible: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
fast: false
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_c72a05fb_bc0d_475e_b3b7_9468cec5d285
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9BT22
initial concentration: NaN
type: Species
is encoded by: hsa:56052
name: ALG1

http://identifiers.org/biomodels.db/MODEL1310110031#_2044d466_b799_47a6_bb76_fee265fd6aae
name: PIGB
is: Q92521
type: Species
is encoded by: hsa:9488
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaM nad m
type: Species
is: C00003
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f8b7126f_996b_4ab7_8a0d_ca5f84371ab5
is encoded by: hsa:956
boundary condition: true
type: Species
name: ENTPD3
is: O75355
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_4ef39685_5c29_42e0_bed5_26d88062a3af
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2109
constant: false
has only substance units: false
name: ETFB
initial amount: NaN
boundary condition: true

metaM duri n
type: Species
is: HMDB00012
name: 2'-deoxyuridine
is: CHEBI:16450
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaM ac m
is: HMDB00042
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: acetate
is: CHEBI:30089
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM lnlnca c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01388
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_139267d3_050e_4c6b_8279_f6c30127f0e5
constant: false
is: Q16881
has only substance units: false
name: TXNRD1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7296
initial concentration: NaN

metaM cspg e l
has only substance units: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
is: CHEBI:36005
is: HMDB02183
type: Species
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
boundary condition: false

metaR S6TASE19ly
product: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110031#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
is: SBO:0000176

metaM ksii core2 pre10 g
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:28067

metaR r0627
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
type: Reaction
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaM 2dpmhobq m
has only substance units: false
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
constant: false
is: HMDB06484
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:50771
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
type: Species

metaM adprbp e
name: ADP-D-ribose 2'-phosphate(4-)
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
is: HMDB06336
constant: false
initial concentration: 1.0
is: CHEBI:58673
boundary condition: false

metaR SO4CLtex2
reactant: MODEL1310110031#
name: sulfate transport via chloride countertransport (2:1)
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
fast: false
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaM prostgd2 c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin D2(1-)
has only substance units: false
type: Species
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
boundary condition: false

metaM 3oddcoa m
boundary condition: false
name: 3-Oxododecanoyl-CoA
type: Species
is: HMDB03937
has only substance units: false
is: CHEBI:27868
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR RE1517M
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110031#
name: RE1517
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110031#
reversible: true

metaM ksii core2 pre9 g
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110031#_6c521d8f_fa40_42e3_8140_20c2d84ddc9f
name: ACOX3
constant: false
is encoded by: hsa:8310
initial concentration: NaN
boundary condition: true
is: O15254
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR M4MPDOL Lter
kinetic law: MODEL1310110031#
name: m4mpdol flippase
product: MODEL1310110031#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000

metaR r0779
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
type: Reaction
fast: false
kinetic law: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_189b64c7_8b17_4c28_bf59_fdcc64f253e6
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:151531
name: UPP2
is: O95045
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM cholate c
is: CHEBI:29747
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
type: Species

metaR r0739
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

metaR GLAl
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: galactosidase, alpha
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
modifier: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.22
fast: false

metaM adn e
boundary condition: false
is: HMDB00050
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16335
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
name: Adenosine
is: C00212

metaR r0579
type: Reaction
modifier: MODEL1310110031#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:0
type: Species
boundary condition: false
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
is: C00124
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_cbf93fa5_74be_48a9_9bc3_f1d6d7a4f122
is encoded by: hsa:3417
initial concentration: NaN
initial amount: NaN
constant: false
name: IDH1
boundary condition: true
is: O75874
type: Species
has only substance units: false
is: SBO:0000252

metaM nadh x
boundary condition: false
is: CHEBI:57945
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial concentration: 1.0
is: C00004
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1e700794_965d_40c2_9f6f_ad27fd060832
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: DBH
has only substance units: false
is: P09172
boundary condition: true
is encoded by: hsa:1621

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00302
type: Species
is: SBO:0000247
name: UDP-D-galactose(2-)
is: CHEBI:58439
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e68f9602_b419_4965_a176_2ad328a3e3d3
initial amount: NaN
has only substance units: false
is: E2QC23
is encoded by: hsa:23464
is: SBO:0000252
name: GCAT
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR FAOXC161C141m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1c669e98_e623_4c88_9dd9_d997c5ea2141
has only substance units: false
type: Species
is encoded by: hsa:5152
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110031#_2fdb9ea9_c99d_42eb_9fec_a0e013649c47
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3423
initial amount: NaN
name: IDS
boundary condition: true
constant: false
is: B4DGD7

metaM ptdcacoa c
constant: false
type: Species
boundary condition: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: HMDB06499
name: pentadecanoyl Coenzyme A
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX tdcrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR H2Oter
name: H2O endoplasmic reticulum transport
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true

metaR THMP
name: thiamin phosphatase
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaR AHEXASEly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false

metaM dcacoa c
is: C05274
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
is: SBO:0000247
is: CHEBI:61430
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
is: HMDB06404
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_979ea9d9_37bb_4e32_be61_5416dd1f5662
has part: Q02218
has part: P36957
boundary condition: true
is encoded by: hsa:1743
has only substance units: false
type: Species
name: DLD:DLST:OGDH:PDHX
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8050
has part: O00330
is encoded by: hsa:4967
constant: false
is: SBO:0000297
has part: P09622
is encoded by: hsa:1738

http://identifiers.org/biomodels.db/MODEL1310110031#_cd6e461b_0d26_4e3d_9356_2e2c46ef4728
constant: false
name: SLC7A1
type: Species
is encoded by: hsa:6541
boundary condition: true
is: SBO:0000252
is: P30825
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_b2df293b_93d6_4c38_9cf9_3b9121983e38
name: PIGA
initial amount: NaN
is: P37287
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5277
has only substance units: false
constant: false
initial concentration: NaN

metaM mlthf m
boundary condition: false
has only substance units: false
is: HMDB01533
type: Species
constant: false
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: CHEBI:15636
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
initial amount: NaN

metaR r0963
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110031#
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction

metaR RE0828E
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
reversible: false
fast: false
product: MODEL1310110031#
name: RE0828
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_d6433f2a_6115_4d82_8793_42b86e4f2bbb
name: ACADM
is encoded by: hsa:34
is: P11310
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaM 3hbcoa m
constant: false
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: HMDB01166
initial concentration: 1.0
has only substance units: false
is: CHEBI:57316
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2cc253c3_2915_4be6_a349_9b493868cbb7
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: _AI601100_1_m
is: SBO:0000252
is encoded by: hsa:AI601100

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
boundary condition: false
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0

metaM dlnlcgcoa m
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false
constant: false

metaM cspg b e
type: Species
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial amount: NaN
is: CHEBI:17568
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: C00106
is: HMDB00300
initial concentration: 1.0

metaR FAOXC12DCc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaM cholcoa x
constant: false
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
type: Species
name: choloyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57373
is: HMDB01374
has only substance units: false

metaM ksi deg16 l
constant: false
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
name: keratan sulfate I, degradation product 16
type: Species
is: CHEBI:57455
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01354

metaR UMPK2n
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110031#
fast: false
type: Reaction
name: UMP kinase (CTP),nuclear

metaR FAOXC5C5OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR r0578
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110031#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_59e1622b_2220_46e7_b3db_030df8c96658
type: Species
is: SBO:0000252
is encoded by: hsa:1545
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: CYP1B1
boundary condition: true
constant: false
is: Q16678

metaR DM ethamp r
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM 6dhf e
initial amount: NaN
name: hexaglutamyl folate (DHF)
is: SBO:0000247
is: HMDB06563
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
boundary condition: false

metaR GLCt4
fast: false
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: glucose transport via sodium symport
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD

metaM dmnoncrn x
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
is: HMDB06202

http://identifiers.org/biomodels.db/MODEL1310110031#_ced52895_a975_4cfa_886b_d6e10908998e
is: SBO:0000252
initial concentration: NaN
is: P07686
is encoded by: hsa:3074
boundary condition: true
name: HEXB
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR UAGALDP
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: UDP-N-acetylgalactosamine diphosphorylase

http://identifiers.org/biomodels.db/MODEL1310110031#_457f6647_539f_4fa2_b057_8f75fbb6f61e
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: A8K7J7
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3098
name: HK1

metaR FORt2m
name: formate mitochondrial transport
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

metaM 3hexdtricoa x
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02288
constant: false
name: 3,7,10-hexadecatrienoylcoa
is: SBO:0000247

metaR r0575
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

metaR r2080
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
fast: false

metaR r0840
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
fast: false
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.14.13.70
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#

metaM ribflv e
type: Species
name: Riboflavin
is: SBO:0000247
is: C00255
boundary condition: false
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: HMDB00244
initial amount: NaN
is: CHEBI:3554
has only substance units: false

metaR RE1796M
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

metaR r0735
type: Reaction
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_8d12195a_c9bb_48da_b73b_dc923675ab53
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:C7orf24
constant: false
is: SBO:0000252
initial concentration: NaN
name: _C7orf24_1_m
boundary condition: true

metaR NACHEX27ly
reversible: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
fast: false
kinetic law: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110031#
type: Reaction

metaR FATP3t
fast: false
name: fatty acid electroneutral transport
product: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

metaR FAOXC226C227m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_5a3486e6_1f19_45ca_96ff_3e9153059514
is: P21399
initial concentration: NaN
initial amount: NaN
name: ACO1
type: Species
is encoded by: hsa:48
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM 13 cis retn r
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06219
is: D00348
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaM succoa c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: Succinyl-CoA
is: HMDB01022
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110031#_57cdb88a_6b8c_4a90_a3af_5a65fe01a1f4
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: CA12
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:771

metaR r0841
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.271
is: SBO:0000185
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
kinetic law: MODEL1310110031#
name: Free diffusion
type: Reaction
reactant: MODEL1310110031#

metaR r0463
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#

metaR r2081
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
reversible: true
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_3b638cc4_b2af_46f6_a5e8_b04cda68ba92
name: SLC28A1
has only substance units: false
is: O00337
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9154
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR ARACHDt2
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR S4TASE3ly
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
product: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176

metaR GPIDA2er
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
reversible: false
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110031#

metaM dpcoa c
is: C00882
constant: false
is: CHEBI:57328
boundary condition: false
name: Dephospho-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: HMDB01373
has only substance units: false

metaR PSDm hs
fast: false
type: Reaction
name: Phosphatidylserine decarboxylase
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reactant: MODEL1310110031#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.65
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
reversible: false

metaM cs e deg4 l
is: CHEBI:15748
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
is: HMDB00127
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR TTDCPT2
is: SBO:0000176
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
name: carnitine transferase
modifier: MODEL1310110031#

metaM dolglcp L r
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247
is: CHEBI:15812
boundary condition: false

metaR r2082
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR DM anth
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM ksi deg35 l
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 35
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial amount: NaN
constant: false
boundary condition: false

metaR r0842
name: Postulated transport reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72

metaM ksii core4 pre7 g
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00130
type: Species
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN

metaM adn c
boundary condition: false
initial concentration: 1.0
is: C00212
name: Adenosine
is: SBO:0000247
has only substance units: false
is: HMDB00050
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
initial amount: NaN
type: Species

MODEL1310110031
reaction: metaR BPNT
species: metaM lnlccoa m
reaction: metaR PROD2m
species: metaM leuktrD4 e
species: metaM c81crn e
reaction: metaR EX 7thf LPAREN e RPAREN
species: metaM cspg e l
reaction: metaR r2386
reaction: metaR CSEPASEly
species: metaM CE4872 m
species: metaM damp c
reaction: metaR HDD2COAtx
reaction: metaR INOSTO
reaction: metaR r0249
reaction: metaR THRGLNNaEx
species: metaM tridcoa m
reaction: metaR C80CPT1
species: metaM but c
species: metaM core2 g
species: metaM atp c
reaction: metaR CYTK5
reaction: metaR r1641
reaction: metaR S4TASE4ly
species: metaM 3dpdhb me m
species: metaM ddeccrn e
reaction: metaR r1594
species: metaM 3dsphgn c
reaction: metaR FACOAL170
reaction: metaR RE2999M
reaction: metaR r1634
reaction: metaR EX 9 cis retfa LPAREN e RPAREN
reaction: metaR PCHOLP hs
reaction: metaR S4TASE2ly
reaction: metaR NCAMDe
reaction: metaR EX ppa LPAREN e RPAREN
reaction: metaR NACHEX15ly
species: metaM adrnl c
reaction: metaR EX bilirub LPAREN e RPAREN
reaction: metaR FUMTSULtm
reaction: metaR r2389
species: metaM ca2 c
reaction: metaR r0792
reaction: metaR ACETONEt2
species: metaM h2o m
reaction: metaR THRALANaEx
species: metaM dhcholoylcoa x
reaction: metaR GALU
species: metaM dd3coa x
species: metaM ump g
species: metaM lac L e
species: metaM acgal l
reaction: metaR EX vitd3 LPAREN e RPAREN
reaction: metaR CRNtim
reaction: metaR FAOXC225C226x
species: metaM aicar c
reaction: metaR N3Tg
species: metaM 7dhchsterol c
species: metaM oh1 c
reaction: metaR CYTK8
reaction: metaR EX hdca LPAREN e RPAREN
reaction: metaR r1644
reaction: metaR NACHEXA20ly
reaction: metaR VALt5m
species: metaM thf m
species: metaM thcholstoic m
reaction: metaR r1597
reaction: metaR FAS160COA
reaction: metaR r1912
species: metaM 4abutn c
reaction: metaR DOLPGT2 Ler
reaction: metaR r1693
reaction: metaR EX gthrd LPAREN e RPAREN
reaction: metaR HEXDIACTD
reaction: metaR r1575
species: metaM taur e
reaction: metaR GARFT
species: metaM lnlccoa c
species: metaM aps c
species: metaM ptth m
reaction: metaR TXA2te

metaR GAO1g
name: Ganglioside O-acetylation
is: SBO:0000176
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
fast: false
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is described by: ECO:0000269

metaR 35CGMPtn
name: 35cGMP nuclear transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
is described by: ECO:0000000

metaR C180CRNt
is: SBO:0000185
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: C180 transport into the mitochondria
fast: false
reversible: false
reactant: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

http://identifiers.org/biomodels.db/MODEL1310110031#_2afb1c62_7fef_4c37_8461_eb08f9d0e553
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4709
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q6IB80
name: NDUFB3

metaR TTDCPT1
modifier: MODEL1310110031#
name: carnitine O-palmitoyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110031#
reversible: false

metaM octe5coa x
boundary condition: false
type: Species
name: 5-octenoylcoa
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
has only substance units: false

metaM ribflv c
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false
is: C00255
is: CHEBI:3554
name: Riboflavin
is: HMDB00244
type: Species
initial amount: NaN
is: SBO:0000247

metaM nadh r
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57945
has only substance units: false
is: SBO:0000247
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487

metaR C16OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaM 5aizc c
is: SBO:0000247
is: C04751
is: CHEBI:58564
initial concentration: 1.0
type: Species
constant: false
is: HMDB06273
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_0e8c5d7f_cbb3_45f8_9c0a_b6bc3dc68a0a
constant: false
is: B5MCC7
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACP1
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:52

metaR r0960
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reactant: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is: SBO:0000185

metaR GLCAASE7ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
name: beta-glucuronidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
type: Reaction

metaM q10h2 m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
constant: false
name: Ubiquinol-10
is: HMDB13111
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR r2083
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a2126b1b_8ce7_4107_a0c8_25b479dd1bed
initial concentration: NaN
boundary condition: true
name: PIK3CA:PIK3R1
is encoded by: hsa:5295
constant: false
is: SBO:0000297
has only substance units: false
initial amount: NaN
has part: P27986
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_f9735678_cb59_4155_af02_cf7993b86e9e
type: Species
name: NDUFA11
is: SBO:0000252
boundary condition: true
is: C9JT23
is encoded by: hsa:126328
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM dpcoa e
initial amount: NaN
is: CHEBI:57328
has only substance units: false
boundary condition: false
name: Dephospho-CoA
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
constant: false
is: C00882

metaM dlnlcgcoa r
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
constant: false
type: Species
boundary condition: false
is: C03595
is: CHEBI:27979
initial concentration: 1.0
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN

metaR RE1807C
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
fast: false
reversible: true
name: RE1807
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000000

metaR VD3
fast: false
product: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
name: Vitamin D3 formation
is: SBO:0000176
is described by: ECO:0000134

metaR RE1519M
name: RE1519
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000

metaR r0571
is version of: http://identifiers.org/ec-code/1.5.1.8
reactant: MODEL1310110031#
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
fast: false

metaM i e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: iodide
is: CHEBI:16382
is: HMDB12238

http://identifiers.org/biomodels.db/MODEL1310110031#_ee0cf0d3_5ccd_432f_b0ea_7e57b139ea05
is encoded by: hsa:56954
boundary condition: true
type: Species
is: Q9NQR4
has only substance units: false
name: NIT2
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110031#
reversible: true
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#

metaM CE2421 m
is: CHEBI:30623
has only substance units: false
is: HMDB02329
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
name: (3S)-3-hydroxylinoleoyl-CoA
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR TRPHYDRO2
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.16.4
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reversible: false

metaR ADSS
reversible: false
product: MODEL1310110031#
name: adenylosuccinate synthase
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.3.4.4
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is: SBO:0000176
fast: false
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM acglcgalgluside hs g
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17103
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_737ffa14_8b33_4859_a2bd_38cca75f1bc2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:27068
name: PPA2
has only substance units: false
initial amount: NaN
is: F8WDN9
constant: false

metaR r0731
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
type: Reaction
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#

metaR FAOXC4C4DCc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_a3a5afd2_f6a7_461c_af41_9222bfa08dbb
has part: P53597
is encoded by: hsa:8802
is: SBO:0000297
name: SUCLG2:SUCLG1
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
has part: Q96I99
is encoded by: hsa:8801
constant: false

metaM 3hdeccoa c
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
name: 3-hydroxyhexadecenoylcoa
type: Species
initial concentration: 1.0
constant: false
is: HMDB02014
boundary condition: false
has only substance units: false

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR r1109
type: Reaction
kinetic law: MODEL1310110031#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is: SBO:0000176
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#

metaR FAOXC143C123m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR NDPK1n
fast: false
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110031#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reactant: MODEL1310110031#

metaR COt
fast: false
name: CO transporter via diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
type: Reaction
kinetic law: MODEL1310110031#

metaR r2330
is described by: ECO:0000000
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR TXA2te
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
fast: false
name: thromboxane A2 transport
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
is: SBO:0000185

metaR r0732
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110031#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_1305d3f2_807a_404b_b45c_7a624e5823ca
is encoded by: hsa:5728
is: SBO:0000252
is: F6KD01
has only substance units: false
constant: false
name: PTEN
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_04a20df4_bb86_464b_8750_60def7676962
constant: false
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _HG2846_HT2983_1_c
has only substance units: false

metaM i c
initial concentration: 1.0
has only substance units: false
is: CHEBI:16382
is: HMDB12238
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
constant: false
initial amount: NaN
name: iodide
type: Species

metaR PHEt4
is described by: ECO:0000269
is: SBO:0000185
name: L-phenylalanine transport in via sodium symport
kinetic law: MODEL1310110031#
fast: false
reversible: false
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
modifier: MODEL1310110031#
type: Reaction

metaM CE5786 e
boundary condition: false
type: Species
name: kinetensin
is: CHEBI:27485
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02710
constant: false
has only substance units: false

metaM m4mpdol L r
boundary condition: false
has only substance units: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110031#_4fc1eb9c_7a44_46be_8bbb_b574cffd1767
initial amount: NaN
is encoded by: hsa:AA977580
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AA977580_1_c
type: Species

metaR r0464
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
fast: false
is described by: ECO:0000000

metaR r0733
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction

metaM sbcoa c
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
has only substance units: false
is: C02838
is: HMDB00791
initial amount: NaN
is: SBO:0000247
type: Species
name: suberylcoa
boundary condition: false
constant: false

metaM thmpp m
initial amount: NaN
is: CHEBI:45931
boundary condition: false
name: Thiamine diphosphate
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
type: Species
constant: false
is: HMDB01372
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR r0570
reversible: true
modifier: MODEL1310110031#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110031#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110031#

metaR GLYC3PFADm
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: glycerophosphate shuttle for trasnfer of reducing equivalents
product: MODEL1310110031#
reversible: false
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction

metaM nrpphr c
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00216
boundary condition: false
is: CHEBI:33569
has only substance units: false
initial amount: NaN
name: Norepinephrine
constant: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaM dcacoa m
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
is: CHEBI:61430
is: C05274
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_1a9568e5_4082_4d6f_9d27_10de6b9d3e22
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
type: Species
is encoded by: hsa:522
has only substance units: false
constant: false
initial amount: NaN
has part: Q6NZ59
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
is: CHEBI:61648
initial amount: NaN
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_8a813129_e03c_45d7_9ed3_10641a26e7b5
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: _AI480132_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:AI480132
boundary condition: true
constant: false

metaM dolglcp U r
is: CHEBI:15812
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_dd041163_54f0_4025_803d_13c3c0806d7f
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: MGAT3
is encoded by: hsa:4248
has only substance units: false
is: Q09327
boundary condition: true
type: Species

metaM ptdcacoa m
is: SBO:0000247
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
initial amount: NaN
boundary condition: false
type: Species
is: HMDB06499
constant: false
initial concentration: 1.0
has only substance units: false
name: pentadecanoyl Coenzyme A

metaM dolp L r
boundary condition: false
initial amount: NaN
name: dolichyl phosphate(2-)
is: CHEBI:57683
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r0734
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reversible: false
type: Reaction
fast: false
product: MODEL1310110031#

metaR FAOXC18C18OHm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR ADPtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
name: ADP transporter, peroxisomal
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction

metaM so4 c
type: Species
boundary condition: false
name: sulfate
has only substance units: false
is: HMDB01448
is: CHEBI:16189
is: SBO:0000247
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
initial amount: NaN

metaR EX c5dc
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR IDPtn
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
name: IDP nuclear transport
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction

metaM udpgal g
is: CHEBI:58439
initial amount: NaN
is: HMDB00302
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: UDP-D-galactose(2-)
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_f1c3ded8_522e_42d1_a9f5_0802f8cd263a
type: Species
name: ADSS
boundary condition: true
is encoded by: hsa:159
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: P30520
has only substance units: false

metaR r1106
name: Postulated transport reaction
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction

metaM tmndnccrn m
has only substance units: false
is: SBO:0000247
is: CHEBI:0
is: C00378
initial concentration: 1.0
constant: false
is: HMDB00235
boundary condition: false
name: Timnodonyl carnitine
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
initial amount: NaN
type: Species

metaR S6T17g
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110031#
is described by: ECO:0000000

metaR RE1531M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1531
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM gacpail hs c
is: HMDB01401
has only substance units: false
boundary condition: false
is: C00092
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
type: Species
constant: false
initial amount: NaN
is: CHEBI:61548
initial concentration: 1.0

metaM fru c
constant: false
has only substance units: false
name: D-Fructose
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:15824
type: Species
is: C00095
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
boundary condition: false

metaM hexdiac r
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: C08260
is: HMDB00672
is: SBO:0000247
initial concentration: 1.0
name: hexadecanediocacid

metaR ELAIDCPT1
fast: false
reversible: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000269
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_0a34d9a2_8a87_4037_85fd_430cd6ae7f1d
boundary condition: true
has only substance units: false
name: GALNT14
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q96FL9
is encoded by: hsa:79623
initial concentration: NaN

metaM nrpphr e
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
initial concentration: 1.0
is: CHEBI:33569
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: Norepinephrine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_c9b2026a_7b7c_48ae_9584_5fe03fe2368f
boundary condition: true
is encoded by: hsa:55089
is: SBO:0000252
is: Q969I6
name: SLC38A4
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR SO4t4 2
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
kinetic law: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
name: sulfate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#

metaM nadh m
is: SBO:0000247
is: HMDB01487
is: CHEBI:57945
constant: false
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaM ksi deg24 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 24
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
is: HMDB00143
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_773336e7_2662_4170_9e92_bce33cb417c1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1892
is: P30084
initial amount: NaN
has only substance units: false
constant: false
name: ECHS1

http://identifiers.org/biomodels.db/MODEL1310110031#_d17a239e_c66f_4356_a782_a2d6dc9415ae
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: CTPS2
is encoded by: hsa:56474
is: Q9NRF8
initial amount: NaN

metaR FAOXC183C163m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

metaR ELAIDCPT2
modifier: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110031#_87c829af_8dd7_423d_bcce_1d76553bfd2b
is encoded by: hsa:9154
has only substance units: false
is: SBO:0000252
is: Q96PL7
initial amount: NaN
name: SLC28A1
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_afe92746_be63_40f0_b556_4f58229b7c45
has only substance units: false
initial amount: NaN
boundary condition: true
is: P47895
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ALDH1A3
is encoded by: hsa:220

http://identifiers.org/biomodels.db/MODEL1310110031#_d4849ce2_1985_4fba_8883_242e6127e778
type: Species
initial concentration: NaN
is encoded by: hsa:9187
constant: false
has only substance units: false
is: SBO:0000252
is: B4DUG1
boundary condition: true
initial amount: NaN
name: SLC24A1

metaM udpgal e
is: CHEBI:58439
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00302
initial concentration: 1.0
name: UDP-D-galactose(2-)
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

http://identifiers.org/biomodels.db/MODEL1310110031#_5d3eb9a3_ef14_4763_b253_bca0871b81d3
constant: false
name: NT5C3
initial concentration: NaN
is: Q9H0P0
is encoded by: hsa:51251
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM so4 e
type: Species
is: HMDB01448
boundary condition: false
name: sulfate
is: SBO:0000247
has only substance units: false
is: CHEBI:16189
constant: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0

metaR UMPK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
name: UMP kinase (dATP)
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction

metaR FAOXTC182TC162m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM ksi pre14 g
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 14
is: CHEBI:28067
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
is: SBO:0000247
constant: false
initial amount: NaN

metaM cs e deg7 l
notes: FORMULA: C23H35O27S2 CHARGE: -3
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: CHEBI:15936

metaM dpcoa l
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
boundary condition: false
type: Species
is: HMDB01373
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57328

metaR C9BRxtc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaR 4HPRO LTte
kinetic law: MODEL1310110031#
name: Transport of trans-4-hydroxy-L-proline
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000134
fast: false
reversible: true

metaR S6T1g
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176

metaR RE1807M
kinetic law: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110031#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
fast: false

metaM cs a deg3 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB00127
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15748
initial concentration: 1.0

metaR UMPK6
product: MODEL1310110031#
name: UMP kinase (dCTP)
modifier: MODEL1310110031#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110031#
is described by: ECO:0000269

metaM fru e
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: D-Fructose
is: CHEBI:15824
type: Species
is: C00095
is: HMDB00660
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false

metaM 3hexdtricoa m
initial concentration: 1.0
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 3,7,10-hexadecatrienoylcoa
is: HMDB02288
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR GLUt2m
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
product: MODEL1310110031#
reversible: true
name: L-glutamate reversible transport via proton symport, mitochondrial
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#

metaR TMNDNCt
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false

metaR P450SCC1m
type: Reaction
name: cholesterol monooxygenase
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_096b757a_eb1d_46a8_837f_a55cbd355b44
type: Species
name: LIPC
is: SBO:0000252
initial concentration: NaN
constant: false
is: A6H8L5
has only substance units: false
is encoded by: hsa:3990
initial amount: NaN
boundary condition: true

metaR GLYt2r
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: true
name: glycine reversible transport via proton symport
is described by: ECO:0000304
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
fast: false

metaR B3GNT314g
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_f06f70df_6059_4ab9_bc8f_bafd4e128a73
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10873
name: ME3
boundary condition: true
type: Species
is: Q6TCH8

metaM dpcoa m
initial concentration: 1.0
type: Species
name: 3'-dephospho-CoA(2-)
is: HMDB01373
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57328
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

http://identifiers.org/biomodels.db/MODEL1310110031#_fc434f9f_3cb7_4718_8ce7_da6e69d02808
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2517
is: SBO:0000252
is: P04066
boundary condition: true
type: Species
initial amount: NaN
name: FUCA1

metaR r0730
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
fast: false
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110031#
reversible: false

metaR r2497
type: Reaction
reversible: false
reactant: MODEL1310110031#
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#

metaR B3GNT36g
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false

metaR UMPK7
modifier: MODEL1310110031#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
name: UMP kinase (dGTP)

metaR FAS80COA L
is described by: ECO:0000269
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_36322f5d_3ce7_40b8_b57e_6ca770301d17
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P00492
name: HPRT1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:3251

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR FUT911g
name: Alpha-(1,3)-fucosyltransferase
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.152
reactant: MODEL1310110031#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269

metaR LYStiDF
reversible: false
modifier: MODEL1310110031#
name: L-lysine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_38fdb9bb_dc9d_407d_9899_f9f71facbbb7
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PDE9A
constant: false
is encoded by: hsa:5152
has only substance units: false
type: Species
boundary condition: true

metaR FAOXC122C101m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_f3ca1b06_53bb_480c_b8f2_1dcb688a6c3e
is: SBO:0000252
name: COX6C
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1345
constant: false
is: P09669

metaR DOLPMT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.258
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaM phe L e
is: SBO:0000247
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
is: CHEBI:17295
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB00159

metaM pydxn c
is: C00314
is: HMDB00239
constant: false
is: CHEBI:16709
name: Pyridoxine
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_cfa6f93e_03cf_43be_a1ac_fd4297f677cb
is: Q5DSZ6
initial amount: NaN
is encoded by: hsa:54576
has only substance units: false
type: Species
name: UGT1A8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM 4hexdtricoa x
initial amount: NaN
is: SBO:0000247
is: HMDB02288
type: Species
initial concentration: 1.0
name: 4,7,10-hexadecatrienoylcoa
constant: false
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false

metaM ksi pre22 g
constant: false
is: SBO:0000247
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22
is: C00130
type: Species
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175

metaR ADSK
fast: false
name: adenylyl-sulfate kinase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.25

metaR r2338
is: SBO:0000185
type: Reaction
fast: false
reversible: true
product: MODEL1310110031#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000

metaR RE3006M
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: RE3006
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true

metaR MCCCrm
type: Reaction
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is version of: http://identifiers.org/ec-code/6.4.1.4
is described by: ECO:0000269
modifier: MODEL1310110031#

metaR GLCNACASE2ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_02f55842_0c6f_4daf_992d_52713c185478
is: Q53G02
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1603
name: DAD1
initial concentration: NaN

metaR NACHEX17ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110031#
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
is: CHEBI:15347
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: Type IIIA glycolipid
type: Species
boundary condition: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: HMDB01659

http://identifiers.org/biomodels.db/MODEL1310110031#_36baecaf_0290_4567_b1f1_1e1e5c530a1d
name: _AA526438_1_c
is encoded by: hsa:AA526438
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR S6T2g
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_e631d40b_1903_4909_bc4e_2baebd0e3b83
boundary condition: true
name: DGKH
initial concentration: NaN
is encoded by: hsa:160851
type: Species
is: SBO:0000252
constant: false
is: Q86XP1
initial amount: NaN
has only substance units: false

metaM ksi deg33 l
constant: false
is: SBO:0000247
is: HMDB00143
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 33
initial amount: NaN
boundary condition: false
is: CHEBI:12936

metaM CE1943 e
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
is: CHEBI:30623
name: spermidine dialdehyde

metaM uacgam g
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
boundary condition: false
has only substance units: false

metaM btn c
is: CHEBI:3420
type: Species
has only substance units: false
is: C00120
initial amount: NaN
boundary condition: false
is: HMDB00030
initial concentration: 1.0
constant: false
name: Biotin
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110031#_5b1401b2_177d_4dad_b48e_c8fc79e435ab
has only substance units: false
is encoded by: hsa:6559
type: Species
boundary condition: true
name: SLC12A3
is: P55017
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaM q10h2 c
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM orot5p c
is: C01103
boundary condition: false
initial concentration: 1.0
is: HMDB00218
constant: false
is: SBO:0000247
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57538
name: Orotidine 5'-phosphate

metaR r0027
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reactant: MODEL1310110031#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true

metaM msa m
type: Species
is: CHEBI:33190
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: SBO:0000247
has only substance units: false
name: 3-oxopropanoate
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB11111
boundary condition: false

metaM CE0693 m
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
constant: false
type: Species
has only substance units: false
name: 3-oxolaur-6-cis-enoyl-CoA
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
boundary condition: false
is: CHEBI:28387
initial amount: NaN

metaM phe L c
is: SBO:0000247
has only substance units: false
name: L-phenylalanine
type: Species
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
is: CHEBI:17295
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM hgentis c
name: homogentisate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
constant: false
is: HMDB00130
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16169
type: Species

metaM 2mbcoa m
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: CHEBI:57336
boundary condition: false
initial amount: NaN
is: HMDB01041

metaR FAOXC184m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM mpdol U c
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
is: CHEBI:18396
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_475bdb6b_2255_4c11_bae9_60de8e95d29b
name: PNPO
is: Q9NVS9
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:55163
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR PSSA1 hs
modifier: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is version of: http://identifiers.org/ec-code/2.7.8.29
kinetic law: MODEL1310110031#
type: Reaction
name: Phosphatidylserine synthase homo sapiens
is described by: ECO:0000269
reversible: true
fast: false

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
reactant: MODEL1310110031#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR P4501B1r
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.14.1
name: cytochrome P450 1B1
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
reversible: false
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR LNLCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
modifier: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000176
name: carnitine transferase
reactant: MODEL1310110031#

metaR DOLGLCP Uter
is: SBO:0000185
kinetic law: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction

metaM tmndnccrn c
initial amount: NaN
is: SBO:0000247
name: Timnodonyl carnitine
has only substance units: false
type: Species
is: HMDB00235
initial concentration: 1.0
boundary condition: false
is: C00378
is: CHEBI:0
constant: false
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1

metaM cholcoads x
constant: false
initial concentration: 1.0
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
boundary condition: false
is: HMDB06889
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
initial amount: NaN
is: SBO:0000247
is: CHEBI:27505

http://identifiers.org/biomodels.db/MODEL1310110031#_ca74444b_d2dd_434d_bcb8_aeef314cef8a
constant: false
is: P43251
initial concentration: NaN
has only substance units: false
is encoded by: hsa:686
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: BTD

metaR r0139
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
type: Reaction
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00304
constant: false
has only substance units: false
type: Species
is: CHEBI:57847
name: Type IIIA glycolipid
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0

metaM HC01231 m
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480
constant: false
boundary condition: false

metaR PGI
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.3.1.9
name: glucose-6-phosphate isomerase
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_98740b42_6df6_4e12_acf5_8eaa07e45926
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GCK
is encoded by: hsa:2645
constant: false
boundary condition: true
initial amount: NaN
is: P35557
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_b7d372fe_7521_4584_81e2_24d2fb4f1657
initial amount: NaN
has only substance units: false
type: Species
is: P51553
boundary condition: true
initial concentration: NaN
name: IDH3G
is encoded by: hsa:3421
is: SBO:0000252
constant: false

metaM thf m
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
is: HMDB01846
constant: false
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247
has only substance units: false
type: Species
is: C00101

metaM btn e
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
initial amount: NaN
is: C00120
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00030
boundary condition: false
initial concentration: 1.0
name: Biotin

metaR ABTArm
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
product: MODEL1310110031#
modifier: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110031#_5206dc8a_1d04_4fa4_859f_f4994959a381
type: Species
is: SBO:0000297
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:23533
has part: Q8WYR1
name: PIK3R5:PIK3CG

metaR LNLCCPT1
is: SBO:0000176
reversible: false
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaM undcoa m
constant: false
name: undecanoylcoa
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
is: HMDB13114

metaR r2335
product: MODEL1310110031#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185

metaM hs deg10 l
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
has only substance units: false
constant: false
is: CHEBI:15748
name: heparan sulfate, degradation product 10
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00127

metaR RE3273C
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
reactant: MODEL1310110031#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
name: RE3273

metaR FK
is: SBO:0000176
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.52
type: Reaction
is described by: ECO:0000000
name: Fucokinase
fast: false
product: MODEL1310110031#

metaR SUCOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: Succinate--CoA ligase (GDP-forming)

metaM spc hs c
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: sphingosylphosphorylcholine
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_09349f78_402e_42d7_ba2a_a87d86454d74
type: Species
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252
name: FOLR1
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaM ksi pre11 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 11
is: SBO:0000247
constant: false
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
type: Species
has only substance units: false
boundary condition: false

metaM gtp c
is: HMDB01273
is: SBO:0000247
name: GTP
type: Species
is: C00044
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: CHEBI:37565
has only substance units: false
initial amount: NaN
boundary condition: false

metaR NDP8ex
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110031#
name: nucleoside-diphosphatase (UTP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176

metaM accoa m
boundary condition: false
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: SBO:0000247
name: Acetyl-CoA
initial concentration: 1.0
is: HMDB01206
is: C00024
has only substance units: false
constant: false
initial amount: NaN

metaR THMDt4
name: thymidine transport in via sodium symport
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is described by: ECO:0000269
fast: false
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_0a2315ff_cd6c_4fd9_b8ee_424751b059c7
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:H77542
name: _H77542_1_c
constant: false
boundary condition: true
initial concentration: NaN

metaR r0021
product: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110031#

metaR r2334
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_310207cf_dbe2_446e_b2e7_789072cd9635
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55229
name: PANK4
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9NVE7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_897b487e_bf95_4e07_9e02_127df6ee3f23
name: MVK
is encoded by: hsa:4598
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: B2RDU6

metaR O2tn
name: O2 nuclear transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110031#

metaR FAOXC9C7m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM ksi deg22 l
is: SBO:0000247
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
name: keratan sulfate I, degradation product 22
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01354
has only substance units: false
is: CHEBI:57455

metaR PGK
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: phosphoglycerate kinase
reversible: true
is version of: http://identifiers.org/ec-code/2.7.2.3
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110031#
modifier: MODEL1310110031#

metaM dgmp e
name: dGMP(2-)
initial concentration: 1.0
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM dlnlcgcoa c
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_61b8d9fa_493a_4f24_aa0b_d30e05b54092
has only substance units: false
initial amount: NaN
constant: false
is: Q16678
boundary condition: true
name: CYP1B1
is: SBO:0000252
type: Species
is encoded by: hsa:1545
initial concentration: NaN

metaM gtp e
type: Species
is: CHEBI:37565
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
initial amount: NaN
name: GTP(4-)
is: HMDB01273
is: SBO:0000247

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM accoa n
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial amount: NaN
name: acetyl-CoA(4-)
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57288
boundary condition: false

metaR r2333
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
reversible: true
product: MODEL1310110031#

metaR GLNtN1
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
name: Glutamine transport (Na, H coupled)
is described by: ECO:0000269
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaM uacgam c
is: HMDB00290
has only substance units: false
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_7dbe5606_ae91_4237_be49_49bb26541120
is: SBO:0000252
is encoded by: hsa:25902
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: MTHFD1L
is: B2RD24
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ddcc7e14_6a9a_4552_8c0e_7702504569d3
constant: false
is encoded by: hsa:9498
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: E7EML0
name: SLC4A8

metaR KSItly
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
product: MODEL1310110031#
name: keratan sulfate I transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#

metaR LEUt4
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000269
name: L-leucine transport in via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
fast: false
is: SBO:0000185

metaR DAGt
is: SBO:0000185
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
name: diacylglycerol transport
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269

metaM 5hoxindact c
initial concentration: 1.0
name: (5-hydroxyindol-3-yl)acetaldehyde
is: SBO:0000247
type: Species
is: CHEBI:50157
boundary condition: false
constant: false
initial amount: NaN
is: HMDB04073
has only substance units: false
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634

metaR O2tm
product: MODEL1310110031#
name: O2 transport (diffusion)
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false

metaM omhpal c
is: SBO:0000247
name: w-hydroxypalmiticacid
is: HMDB06294
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1

metaM damp c
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB00905
name: dAMP(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:58245

http://identifiers.org/biomodels.db/MODEL1310110031#_b7dc8750_0e7c_4711_a42c_9bce6bd2f9de
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: _N63787_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:N63787

http://identifiers.org/biomodels.db/MODEL1310110031#_d5e148cb_cbed_42d4_b3cb_a0b819b1e17c
has only substance units: false
is encoded by: hsa:BC005314
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: _BC005314_1_x
type: Species
boundary condition: true

metaM nadh c
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306
constant: false
is: CHEBI:57945
is: HMDB01487
is: C00004
type: Species
initial concentration: 1.0
has only substance units: false

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_e4223367_cd8b_488b_bb9c_c8938c06e748
is: P00568
boundary condition: true
initial amount: NaN
is encoded by: hsa:203
constant: false
name: AK1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bd692567_5f20_4655_96b3_11e9a2ce1b3e
initial amount: NaN
has only substance units: false
is encoded by: hsa:411
is: SBO:0000252
name: ARSB
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P15848

metaR r2332
product: MODEL1310110031#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_6e5db0e8_29ae_4de3_b2ac_955d2a9ea55c
is: SBO:0000252
constant: false
has only substance units: false
name: ATP8A1
is: Q9Y2Q0
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10396
initial amount: NaN

metaR NORANMT
reversible: false
is: SBO:0000176
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
name: noradrenaline N-methyltransferase
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.1.1.28
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5409.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is described by: ECO:0000269
fast: false
type: Reaction

metaR FAOXC163Gm
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM galacglcgalgbside hs c
is: CHEBI:58343
is: SBO:0000247
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
type: Species
constant: false
has only substance units: false
is: HMDB00061
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Gal-GlcNAc-Gal globoside

metaM spc hs e
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN
type: Species
name: sphingosylphosphorylcholine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_eb9e3687_8e95_4f09_ba2f_6724384664f0
name: _MBOAT5_1_c
initial concentration: NaN
is encoded by: hsa:MBOAT5
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR UDPGD
modifier: MODEL1310110031#
fast: false
name: UDPglucose 6-dehydrogenase
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.22
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_1a2d273a_2618_49a3_a272_0ece4c78dc49
is encoded by: hsa:2717
has only substance units: false
initial amount: NaN
name: GLA
type: Species
is: Q53Y83
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR O2tp
name: O2 transport, peroxisomal
reactant: MODEL1310110031#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
reversible: true

metaM 3mox4hpac m
is: SBO:0000247
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial concentration: 1.0
is: HMDB05175
constant: false
has only substance units: false
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: CHEBI:28111
boundary condition: false
type: Species
initial amount: NaN

metaR MM8Ber
reactant: MODEL1310110031#
fast: false
type: Reaction
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: HMDB01659
is: CHEBI:15347
is: SBO:0000247
boundary condition: false
constant: false
name: Type IIIA glycolipid
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false

metaR r2331
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_fe1e7106_8a8c_4e65_9e00_26e2cb86c234
is encoded by: hsa:11000
is: Q5K4L6
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: SLC27A3
is: SBO:0000252

metaR r0022
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110031#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110031#
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction

metaM m2mpdol U c
has only substance units: false
initial amount: NaN
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28049

metaM dmpp x
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57623
type: Species
initial concentration: 1.0
name: prenyl diphosphate(3-)
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

http://identifiers.org/biomodels.db/MODEL1310110031#_a0f894e0_f24c_4b6e_9341_83508d13d155
is: Q7Z364
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PDE1B
type: Species
constant: false
is encoded by: hsa:5153
initial concentration: NaN
initial amount: NaN

metaR MALSO4tm
reversible: true
modifier: MODEL1310110031#
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185

metaR KYNAKGAT
reactant: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
name: L-Kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64

http://identifiers.org/biomodels.db/MODEL1310110031#_3a7d1f31_a436_403f_bc9b_2fc52e42cdd7
is encoded by: hsa:157570
type: Species
constant: false
name: ESCO2
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q56NI9

metaR FAOXC184x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM galacglcgalgbside hs e
is: CHEBI:0
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00124
name: Gal-GlcNAc-Gal globoside
is: HMDB00143
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_d6261ccd_905e_4053_b9fd_1951578530aa
initial amount: NaN
boundary condition: true
is encoded by: hsa:6898
is: SBO:0000252
initial concentration: NaN
is: P17735
constant: false
type: Species
has only substance units: false
name: TAT

metaR r0130
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
fast: false

metaM omhpal r
type: Species
is: HMDB06294
constant: false
is: SBO:0000247
has only substance units: false
name: w-hydroxypalmiticacid
boundary condition: false
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_e9ee9b2f_3889_479d_a201_63e5d0955022
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: O76082
is encoded by: hsa:6584
type: Species
name: SLC22A5
initial amount: NaN

metaR HDD2COAtx
is described by: ECO:0000000
product: MODEL1310110031#
name: hdd2coa intracellular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false

metaM ksii core2 deg6 l
is: HMDB00143
is: SBO:0000247
type: Species
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C44H72N4O33SX CHARGE: -1
name: keratan sulfate II (core 2-linked), degradation product 6

metaR DCSPTN1t
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000000
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110031#_3eb869be_ac18_4140_8e3b_62c9b5e1ef8f
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: E7ET32
boundary condition: true
is: SBO:0000252
name: GALT
is encoded by: hsa:2592
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_88ac750d_a3cd_45bd_b9f5_2f71533b97bb
is encoded by: hsa:6005
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: RHAG
constant: false
is: Q96E98
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_af185b65_aa14_47d8_a476_527473e55f5c
is: O43677
has only substance units: false
initial concentration: NaN
name: NDUFC1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4717
boundary condition: true

metaM dhcrm hs c
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:31488
initial concentration: 1.0
constant: false
name: dihydroceramide

metaM xoltriol c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: CHEBI:16496
type: Species
constant: false
boundary condition: false
is: HMDB01457
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_58a19eb5_d43f_4767_ae6b_191814819c37
is: SBO:0000252
constant: false
is: Q9NXB9
initial concentration: NaN
initial amount: NaN
name: ELOVL2
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:54898

metaM thymd c
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
is: CHEBI:17748
name: Thymidine
is: SBO:0000247
boundary condition: false
is: C00214
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_6d2c82ad_32e6_4f31_94a7_4fa94d1fea42
is: SBO:0000297
is encoded by: hsa:1603
boundary condition: true
has part: Q53G02
initial concentration: NaN
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:6185
is encoded by: hsa:1650
has part: P04843
initial amount: NaN
type: Species
is encoded by: hsa:6184
has only substance units: false
has part: P04844
has part: P39656
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_8d145715_ba4d_4154_a885_c9e418f51228
is encoded by: hsa:6309
is: Q6GTM5
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SC5DL
type: Species
initial amount: NaN
initial concentration: NaN

metaM acrn c
type: Species
boundary condition: false
is: CHEBI:57589
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
name: O-acetylcarnitine
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_832104a7_3f6d_40a0_ad7b_2509f0033761
name: ACAD11
is encoded by: hsa:84129
constant: false
has only substance units: false
is: SBO:0000252
is: Q709F0
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR SUCCTD
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM galacglcgalgbside hs g
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Gal-GlcNAc-Gal globoside
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: CHEBI:26174
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaR BILIRED
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.24
type: Reaction
reactant: MODEL1310110031#
fast: false
reversible: false
product: MODEL1310110031#
name: Nad(p)h biliverdin reductase
kinetic law: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV

metaM 2hb e
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
has only substance units: false
initial amount: NaN
is: HMDB00008
boundary condition: false
is: CHEBI:1148
type: Species

metaR URATEt
name: urate export from cytosol
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR FUCASE2ly
kinetic law: MODEL1310110031#
is: SBO:0000176
product: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110031#
type: Reaction
fast: false
reactant: MODEL1310110031#
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD

metaM btn m
is: HMDB00030
is: CHEBI:57586
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
type: Species
is: SBO:0000247
initial amount: NaN
name: biotinate
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_1f074136_51fd_477b_bd6a_344f88a56b0d
boundary condition: true
is: Q9BZX2
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: UCK2
initial amount: NaN
is encoded by: hsa:7371

metaR AG13T9g
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110031#_5f0b8dd4_cb05_45b2_a3fc_515d33b89241
initial amount: NaN
is encoded by: hsa:79966
is: SBO:0000252
name: SCD5
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q86SK9

metaR SPHS1Ptr
name: sphingosine-1-phosphate transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reactant: MODEL1310110031#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#

metaR XYLt
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
product: MODEL1310110031#
name: D-xylose reversible transport
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
reactant: MODEL1310110031#

metaR LINOFATPtc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR EX c4crn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM chlstol r
is: HMDB06842
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol

metaM dgmp c
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: CHEBI:57673
initial amount: NaN
has only substance units: false
type: Species
is: C00362
is: HMDB01044
name: dGMP
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b1adcaf7_fced_4523_a0bf_6ab631d4a928
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P35218
is encoded by: hsa:763
name: CA5A
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_7d47c7eb_a1ee_4d6d_a8d5_53862f306895
has only substance units: false
type: Species
is encoded by: hsa:10400
boundary condition: true
constant: false
name: PEMT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR GLXO1
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
name: glyoxylate oxidase
is version of: http://identifiers.org/ec-code/1.1.1.27
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is described by: ECO:0000269
type: Reaction

metaR RE3556C
product: MODEL1310110031#
name: RE3556
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
type: Reaction

metaM gpi sig r
initial amount: NaN
initial concentration: 1.0
is: HMDB00224
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
notes: FORMULA: Y CHARGE: 0
is: CHEBI:58190
has only substance units: false

metaR GALASE11ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
product: MODEL1310110031#

metaR CYTDK2m
is described by: ECO:0000000
fast: false
name: cytidine kinase (ATP), mitochondrial
type: Reaction
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110031#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110031#

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR CYSGLYexR
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110031#

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_5e584ca2_1cd6_48a3_99de_15875500c070
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3612
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: B7Z6Q4
name: IMPA1

metaM phytcoa x
is: SBO:0000247
is: HMDB01359
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
constant: false
initial amount: NaN
type: Species
is: CHEBI:57391
boundary condition: false
name: phytanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0

metaM 3hmp m
constant: false
is: SBO:0000247
is: CHEBI:11805
is: HMDB00023
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
name: 3-hydroxy-2-methylpropanoate
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM gtp m
is: HMDB01273
constant: false
is: SBO:0000247
is: C00044
has only substance units: false
initial amount: NaN
is: CHEBI:37565
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_148a7cc1_8063_41ff_bb82_250934fb57a4
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: _100128062_1_m
is encoded by: hsa:100128062

metaM thf c
is: HMDB01846
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110031#_6c1e0f3f_d1b3_41f6_9072_74ba4d799a0d
name: ATP5L
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10632
is: O75964
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_fabf7ac8_985a_4da2_8d87_a42fa5b0fccc
initial concentration: NaN
is: Q9Y666
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC12A7
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:10723

http://identifiers.org/biomodels.db/MODEL1310110031#_054c4f5f_bd5b_49ef_a507_25273ccb61bf
initial concentration: NaN
constant: false
name: _AA021081_1_r
is encoded by: hsa:AA021081
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR TYROXDAc
reversible: false
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
product: MODEL1310110031#
is described by: ECO:0000269
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
type: Reaction
reactant: MODEL1310110031#

metaM gtp n
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: SBO:0000247
is: HMDB01273
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: GTP(4-)
is: CHEBI:37565

metaR r2079
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#

metaM accoa x
type: Species
initial concentration: 1.0
has only substance units: false
is: C00024
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
boundary condition: false
is: HMDB01206
is: CHEBI:57288
name: Acetyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_9a05c555_865e_4bbc_9302_6031ff3ce905
boundary condition: true
type: Species
constant: false
is encoded by: hsa:10327
is: SBO:0000252
name: AKR1A1
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR FAS140COA
product: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is: SBO:0000176
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_ffabe7ba_10b8_4c73_a073_0934b2c7bf84
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P33121
is encoded by: hsa:2180
name: ACSL1
is: SBO:0000252
initial concentration: NaN

metaR LYStm
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: Lysine mitochondrial transport via ornithine carrier
is: SBO:0000185
modifier: MODEL1310110031#
product: MODEL1310110031#
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_5fb915b1_8918_4f32_ac26_31cb5a53bb6c
type: Species
is: SBO:0000252
has only substance units: false
is: P35790
boundary condition: true
name: CHKA
constant: false
is encoded by: hsa:1119
initial concentration: NaN
initial amount: NaN

metaM gacpail hs r
constant: false
is: HMDB01401
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:61548
initial concentration: 1.0

metaR SUCCACT
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM q10h2 e
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
is: HMDB13111
type: Species
constant: false
initial concentration: 1.0
name: Ubiquinol-10
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740

http://identifiers.org/biomodels.db/MODEL1310110031#_2bf82887_678a_42d0_a4e8_f8535ead4df1
initial amount: NaN
is encoded by: hsa:341947
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: COX8C
boundary condition: true
constant: false
is: Q7Z4L0

http://identifiers.org/biomodels.db/MODEL1310110031#_db5ad63d_39f9_42c3_a674_6cfaa9394af7
boundary condition: true
is: Q9Y2Z9
type: Species
has only substance units: false
name: COQ6
is encoded by: hsa:51004
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR FAOXC226C205m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM hexdiac c
is: C08260
constant: false
name: hexadecanediocacid
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00672

metaR G14T2g
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110031#
fast: false
is: SBO:0000176
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
modifier: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM dcacoa x
is: HMDB06404
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: C05274
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b5c71768_873f_4750_995b_e030686be008
is: SBO:0000252
has only substance units: false
constant: false
name: CROT
initial concentration: NaN
is: E7EQF2
type: Species
initial amount: NaN
is encoded by: hsa:54677
boundary condition: true

metaR r0975
kinetic law: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion

metaM ahcys e
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial amount: NaN
is: C00021
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00939
is: CHEBI:16680
boundary condition: false

metaM dhap e
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01473
is: SBO:0000247
constant: false
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6e76848d_c419_4025_a422_33fb320f58fc
initial concentration: NaN
name: BCAT1
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:586
is: P54687

metaM hs deg19 l
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB06210
name: heparan sulfate, degradation product 19

http://identifiers.org/biomodels.db/MODEL1310110031#_1e18c2ab_7f31_492d_9ddb_32a16e8cd7bc
initial amount: NaN
type: Species
name: PIP4K2C
initial concentration: NaN
constant: false
is: B3KQV3
is: SBO:0000252
is encoded by: hsa:79837
has only substance units: false
boundary condition: true

metaM ksi deg25 l
is: HMDB01354
initial amount: NaN
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: CHEBI:57455
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 25
constant: false
has only substance units: false

metaR BTNt4i
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110031#
reversible: false
name: Biotin uptake (antiport)
product: MODEL1310110031#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR FAOXC17C15m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_0e29f823_f110_4bbb_8623_546a04b5c6a9
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6482
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: ST3GAL1

metaR ADRNCRNt
kinetic law: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM bilglcur c
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR H2ETer
modifier: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
product: MODEL1310110031#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110031#
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110031#
is described by: ECO:0000304

metaR PHACCOAGLNAC
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: false

metaR HDECAACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaR r0973
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_0c8d4f13_bea1_43a9_87f0_abc4b46847c5
is encoded by: hsa:2629
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GBA
is: B7Z6S1
is: SBO:0000252
type: Species
boundary condition: true

metaM ksii core4 pre10 g
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247

metaM dem2emgacpail prot hs r
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:53486
initial amount: NaN
is: HMDB02925
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol

metaR EX 3hexdcrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaR PMEVKc
product: MODEL1310110031#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is described by: ECO:0000134
name: phosphomevalonate kinase, cytosol
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.2
modifier: MODEL1310110031#

metaR EICOSTETCPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110031#
name: carnitine transferase

metaM dhap c
has only substance units: false
type: Species
initial concentration: 1.0
is: C00111
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
is: SBO:0000247
constant: false
name: Dihydroxyacetone phosphate
is: CHEBI:57642
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_94da34e1_9b77_494d_904e_057b77038d15
is encoded by: hsa:137872
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q8IWW8
name: ADHFE1
type: Species

metaR DRPA
type: Reaction
reversible: false
product: MODEL1310110031#
is: SBO:0000176
name: deoxyribose-phosphate aldolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaR r0974
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
kinetic law: MODEL1310110031#
type: Reaction
name: Active transport
product: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110031#
reversible: true
fast: false

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR C51CPT1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM CE2420 m
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
is: CHEBI:28387
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: SBO:0000247
constant: false
is: HMDB11123
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r0728
reactant: MODEL1310110031#
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
fast: false

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_0e0025e3_100f_438e_8931_8a777e6dc756
is: SBO:0000252
has only substance units: false
name: ALDH1B1
is encoded by: hsa:219
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110031#_c98395b0_3a8c_4148_891d_33fc819b1479
initial concentration: NaN
type: Species
boundary condition: true
is: Q14376
initial amount: NaN
is encoded by: hsa:2582
is: SBO:0000252
name: GALE
has only substance units: false
constant: false

metaR UDPGALtg
type: Reaction
kinetic law: MODEL1310110031#
name: UDP-Gal Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110031#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_8d0f02f5_5c29_4da0_9335_6fcc56821e7f
constant: false
has only substance units: false
type: Species
is: SBO:0000297
is encoded by: hsa:516
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6FIH7
boundary condition: true
initial concentration: NaN

metaR DOLPMT4 Ler
is: SBO:0000185
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

metaR EICOSTETCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
fast: false
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_81ab5080_72f2_40ef_83af_fde76393c6eb
type: Species
is encoded by: hsa:AI620219
initial amount: NaN
constant: false
has only substance units: false
name: _AI620219_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR LEUt5m
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
name: leucine mitochondrial transport
fast: false
product: MODEL1310110031#

metaM h c
initial concentration: 1.0
name: proton
constant: false
boundary condition: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
is: SBO:0000247
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
initial amount: NaN

metaR ETF
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: electron transfer flavoprotein

metaM dcsptn1crn m
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
constant: false
is: HMDB06321
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
initial concentration: 1.0

metaR S6TASE18ly
fast: false
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110031#
reversible: true

metaM thymd e
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial amount: NaN
initial concentration: 1.0
is: C00214
is: HMDB00273
is: CHEBI:17748
name: Thymidine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_75510877_e12a_4886_9398_23723a4bfd8c
initial concentration: NaN
constant: false
is: SBO:0000252
is: P06865
initial amount: NaN
is encoded by: hsa:3073
type: Species
boundary condition: true
has only substance units: false
name: HEXA

metaR r0830
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110031#

metaR r0472
is: SBO:0000176
reactant: MODEL1310110031#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR 3HCO3 NAt
reactant: MODEL1310110031#
reversible: true
name: 3HCO3_NAt
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is: SBO:0000185

metaR DHFtm
kinetic law: MODEL1310110031#
type: Reaction
name: dihydrofolate reversible mitochondrial transport
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
product: MODEL1310110031#
is described by: ECO:0000000

metaM ksi pre29 g
is: CHEBI:28067
boundary condition: false
has only substance units: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 29

http://identifiers.org/biomodels.db/MODEL1310110031#_4b03abcc_9760_4ffa_b0ab_d9f714c11a52
constant: false
name: TPH2
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q8IWU9
boundary condition: true
is encoded by: hsa:121278

metaR FATP2t
reactant: MODEL1310110031#
is: SBO:0000185
fast: false
product: MODEL1310110031#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#

metaM ach e
has only substance units: false
boundary condition: false
is: SBO:0000247
name: acetylcholine
is: HMDB00895
is: CHEBI:15355
type: Species
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
initial concentration: 1.0

metaR r0726
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110031#

metaR NACHEX20ly
kinetic law: MODEL1310110031#
fast: false
is: SBO:0000176
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR RE2625M
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110031#
fast: false
name: RE2625
product: MODEL1310110031#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#

metaM gal l
initial concentration: 1.0
name: D-galactose
is: CHEBI:12936
constant: false
is: HMDB00143
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_e7ae5a87_cb55_4e5c_9d39_028946057ba0
is: Q16134
type: Species
name: ETFDH
constant: false
boundary condition: true
is encoded by: hsa:2110
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR G14Tg
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
product: MODEL1310110031#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
kinetic law: MODEL1310110031#

metaM dtmp c
initial concentration: 1.0
type: Species
is: C00364
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
is: CHEBI:26999
is: SBO:0000247
is: HMDB01227
has only substance units: false
name: dTMP
constant: false

metaR r1850
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
modifier: MODEL1310110031#
fast: false

metaR ASPTAm
type: Reaction
name: aspartate transaminase
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000269
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD

metaM dodecanac x
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H20O4 CHARGE: -2
has only substance units: false
is: HMDB00623
name: Dodecanedioic acid
type: Species

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
has only substance units: false
constant: false
name: proton
initial concentration: 1.0
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_c06648ae_1c2f_445a_8655_d8ef06c7920b
is: SBO:0000252
is encoded by: hsa:50
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q99798
name: ACO2
initial concentration: NaN
constant: false
type: Species

metaM ps hs m
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
has only substance units: false
is: CHEBI:18303
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: ps_hs[m]

metaR DCYTDn
is: SBO:0000176
product: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
name: deoxycytidine deaminase, nuclear
is described by: ECO:0000254
type: Reaction
reversible: false
reactant: MODEL1310110031#

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR GARFT
is: SBO:0000176
product: MODEL1310110031#
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is described by: ECO:0000269
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
type: Reaction
reversible: true
reactant: MODEL1310110031#
fast: false

metaR HMGCOAtx
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
fast: false
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_32b64ad3_8b6d_43d3_8a59_27aee7df8786
initial amount: NaN
type: Species
name: ALDH18A1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5832
is: P54886

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16680
is: HMDB00939
initial amount: NaN
constant: false
name: S-Adenosyl-L-homocysteine
has only substance units: false
is: C00021

http://identifiers.org/biomodels.db/MODEL1310110031#_a06cebca_da74_4f91_9f13_f13fc125758b
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:22305
name: _22305_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR RE0827E
is: SBO:0000176
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
modifier: MODEL1310110031#
fast: false
product: MODEL1310110031#
name: RE0827
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000

metaM itp n
is: HMDB00189
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: ITP(3-)
boundary condition: false

metaR r0723
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
fast: false
reversible: false
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110031#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
type: Reaction
fast: false
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
modifier: MODEL1310110031#
product: MODEL1310110031#

metaR r0474
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110031#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_5039bca1_e100_4251_90cd_722d9079cc54
is encoded by: hsa:83715
type: Species
name: ESPN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: B1AK53

http://identifiers.org/biomodels.db/MODEL1310110031#_c7559b66_c9cc_4862_8588_b6a92fb38091
initial amount: NaN
is encoded by: hsa:114799
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: ESCO1
is: Q5FWF5
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_868f82ee_2802_461e_9ebb_0fc318f436c3
is: SBO:0000252
is encoded by: hsa:AI818585
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: _AI818585_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_d94bc921_6101_4194_a579_751cb1f78ec4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:226
initial amount: NaN
has only substance units: false
type: Species
is: P04075
initial concentration: NaN
name: ALDOA
constant: false

metaR PHYTt
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110031#
reversible: true
fast: false
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_87c1f86b_c7fd_4699_8912_9b91031174b0
is: Q8TF08
boundary condition: true
is encoded by: hsa:170712
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: COX7B2
constant: false

metaM bilglcur e
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
is: CHEBI:57767
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM ach c
is: CHEBI:15355
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial concentration: 1.0
is: HMDB00895
name: acetylcholine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_713c72c7_d2dd_4287_9f77_23f2c2694da5
name: GALE
constant: false
initial concentration: NaN
is: Q38G75
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2582
is: SBO:0000252
initial amount: NaN

metaR r0724
product: MODEL1310110031#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110031#

metaM xoldiolone r
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
type: Species
is: CHEBI:28477
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
initial amount: NaN
is: HMDB02197
initial concentration: 1.0

metaR r0475
product: MODEL1310110031#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01227
is: CHEBI:26999
boundary condition: false
constant: false
name: dTMP(2-)

metaM hs deg18 l
constant: false
has only substance units: false
initial concentration: 1.0
name: heparan sulfate, degradation product 18
type: Species
is: HMDB06210
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial amount: NaN

metaM sgalside hs l
name: sulfatide galactocerebroside
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
constant: false
is: CHEBI:16349
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00904

metaM h g
name: proton
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:24636
type: Species

metaM amp x
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
initial amount: NaN
is: C00020
type: Species
constant: false
name: AMP
boundary condition: false
is: CHEBI:456215
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_7341a863_e905_4d32_8e66_5de5373a08cf
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6916
is: SBO:0000252
name: TBXAS1
type: Species
boundary condition: true
initial concentration: NaN
is: Q53F23

metaR LCADi D
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
name: lactaldehyde dehydrogenase
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_a7667909_a535_4a2e_81cd_a86d6e013db6
is: SBO:0000252
boundary condition: true
is: F5H066
constant: false
type: Species
name: SLC12A4
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6560

metaR ARACHCPT2
name: carnitine transferase
type: Reaction
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR FAOXC18280m
kinetic law: MODEL1310110031#
name: Beta oxidation of fatty acid
modifier: MODEL1310110031#
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
fast: false

metaM 3docopencoa x
name: 3,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
type: Species
constant: false

metaR CSNAT2x
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
reversible: true
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.137

metaM decdp c
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06288
boundary condition: false
name: all trans Decaprenyl diphosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_a74e29ce_7f43_4190_8fa4_99f0f705d83d
boundary condition: true
is encoded by: hsa:8706
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q49AT3
name: B3GALNT1
initial amount: NaN

metaR CBASPte
fast: false
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000134
name: Transport of N-carbamoyl-L-aspartate
kinetic law: MODEL1310110031#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110031#_d7cf815b_858c_43bf_89bf_5448ce683c92
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O95470
type: Species
constant: false
name: SGPL1
is encoded by: hsa:8879
initial concentration: NaN
has only substance units: false

metaR RE1532M
name: RE1532
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR LGNCt
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110031#

metaM gdpmann c
is: SBO:0000247
constant: false
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57527
has only substance units: false
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096

metaM HC01407 m
constant: false
initial amount: NaN
is: CHEBI:28276
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
type: Species
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false

metaR FERO
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110031#
type: Reaction
name: ferroxidase
kinetic law: MODEL1310110031#
is described by: ECO:0000134
product: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
reversible: false
fast: false

metaR GCNTg
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.150

metaR ARACHCPT1
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
name: carnitine transferase
fast: false
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_5d2564a5_f22d_4da0_a8d0_1c9dbe852e81
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: MCEE
has only substance units: false
is: SBO:0000252
is: Q96PE7
is encoded by: hsa:84693

metaM leuktrB4 c
initial concentration: 1.0
is: CHEBI:57461
is: SBO:0000247
boundary condition: false
constant: false
name: leukotriene B4(1-)
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110031#_13025721_db3c_4916_99d0_e76ac0dd59f8
has only substance units: false
is encoded by: hsa:5150
type: Species
initial concentration: NaN
name: PDE7A
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_bcb0c7a5_80ec_4108_9132_c8f8a723f3af
is: Q6FGA0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: COX7A2L
is encoded by: hsa:9167
has only substance units: false
boundary condition: true

metaM dcsptn1 e
boundary condition: false
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5282848
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaM accoa c
boundary condition: false
initial amount: NaN
name: Acetyl-CoA
initial concentration: 1.0
has only substance units: false
type: Species
is: C00024
is: CHEBI:57288
is: SBO:0000247
is: HMDB01206
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR r0722
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/4.2.3.12
fast: false

metaR r0835
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16

metaM n2m2nm l
notes: FORMULA: C58H97N5O41 CHARGE: 0
name: n2m2nmasn (w/o peptide linkage)
initial concentration: 1.0
constant: false
is: HMDB06529
initial amount: NaN
has only substance units: false
is: CHEBI:50570
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a1666305_a279_4c7c_8d8a_c98d007152ea
is: SBO:0000252
is: A0N0X8
constant: false
type: Species
initial amount: NaN
name: CYP1A1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1543

http://identifiers.org/biomodels.db/MODEL1310110031#_f3bf9071_ead2_48e8_a625_cfdd735c29b8
is: SBO:0000252
constant: false
name: _AI469183_1_x
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI469183
type: Species
has only substance units: false
initial amount: NaN

metaR ORNTArm
is: SBO:0000176
modifier: MODEL1310110031#
name: ornithine transaminase reversible (m)
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
reversible: true
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.13

http://identifiers.org/biomodels.db/MODEL1310110031#_a4f960ec_2a11_4dd3_a9b8_4f18f4b0e30a
is: SBO:0000252
boundary condition: true
is: Q06830
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5052
name: PRDX1
constant: false
initial amount: NaN

metaM h l
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
name: proton
type: Species
has only substance units: false
initial amount: NaN
is: C00080
is: CHEBI:24636
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "

metaR 34DHPLACOX
is described by: ECO:0000269
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110031#
reversible: false
type: Reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_ca6bcb9c_804f_498b_9229_95d0b39bc8cd
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _LOC647190_1_c
is encoded by: hsa:LOC647190
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR UDPGP
reversible: false
name: UDPglucose pyrophosphohydrolase
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110031#
fast: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.4.39
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
type: Reaction

metaM dmnoncrn c
is: HMDB06202
name: 4,8-dimethylnonanoyl carnitine
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110031#_ffc657aa_ea84_413d_b94d_d0e669676925
is encoded by: hsa:23305
name: ACSL6
initial amount: NaN
is: B2RB13
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
name: Phosphatidylcholine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16110
type: Species
constant: false

metaM mi14p c
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: HMDB00968
is: CHEBI:58282

metaR LALDO2x
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false

metaR r2341
reactant: MODEL1310110031#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a2a2fb93_d73c_4a0c_a6ba_42d840ed27f5
initial amount: NaN
has only substance units: false
is encoded by: hsa:10449
name: ACAA2
boundary condition: true
is: P42765
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_0f3dff1b_d11d_49d7_a21e_a090b909144f
has only substance units: false
is: Q8N0X4
type: Species
is encoded by: hsa:171425
boundary condition: true
initial amount: NaN
constant: false
name: CLYBL
initial concentration: NaN
is: SBO:0000252

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM leuktrB4 e
is: CHEBI:57461
constant: false
initial concentration: 1.0
boundary condition: false
name: leukotriene B4(1-)
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_c2e50c88_8280_47c7_835f_e33ad2893ae8
name: IDS
is encoded by: hsa:3423
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P22304
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR B3GNT313g
fast: false
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000254
reversible: false
product: MODEL1310110031#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110031#

metaR r0584
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true

metaR ACACT1r
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
fast: false
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
name: acetyl-CoA C-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_f83dfee1_14c9_40dd_95d2_e2e4953e4cb9
has only substance units: false
is encoded by: hsa:259230
boundary condition: true
type: Species
is: D3DWC4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SGMS1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_2d5c8d81_8371_46b5_93de_be43b64d5fd0
is: SBO:0000252
is encoded by: hsa:146712
initial concentration: NaN
is: Q67FW5
boundary condition: true
constant: false
initial amount: NaN
name: B3GNTL1
has only substance units: false
type: Species

metaR DESAT22 1p
reactant: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110031#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:

metaR FAOXC12DCx
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM succoa x
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: HMDB01022
initial amount: NaN
name: Succinyl-CoA
has only substance units: false
initial concentration: 1.0

metaR DNDPt27m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
name: dCDP transport via dTDP antiport
reactant: MODEL1310110031#
modifier: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_66a178b6_6d60_407a_86b6_836cb87031db
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:29920
name: PYCR2
has only substance units: false
constant: false
boundary condition: true
is: Q96C36
initial concentration: NaN

metaM lneldccoa m
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
is: HMDB01064
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
name: linoelaidyl coenzyme A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a608cb4f_5b6e_4800_ac47_5e96c8a10c87
type: Species
has only substance units: false
name: NDUFA1
is: Q6IBB5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:4694
constant: false

metaR CMPACNAtg
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
product: MODEL1310110031#
is: SBO:0000185
name: CMP-Sia Golgi transport via CMP antiport

metaM h n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636
name: proton
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_8156c4ad_ff81_47b3_a9b5_cbd3e4591487
name: ATG9B
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:285973
is: Q674R7
type: Species
initial concentration: NaN

metaM sgalside hs g
is: CHEBI:58343
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00061
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: sulfatide galactocerebroside
initial concentration: 1.0
constant: false
initial amount: NaN

metaR HEXDCRNe
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_76e3b196_c54d_464b_9885_9d0cd78abbec
type: Species
initial concentration: NaN
is encoded by: hsa:490
name: ATP2B1
constant: false
is: P20020
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM g3m8mpdol U r
is: C05873
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
type: Species
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20

metaM gal e
is: SBO:0000247
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
constant: false
has only substance units: false
is: C00124
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose

metaR RE1573M
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000000
type: Reaction
name: RE1573
product: MODEL1310110031#

metaR r0838
product: MODEL1310110031#
name: Free diffusion
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
kinetic law: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
reactant: MODEL1310110031#
modifier: MODEL1310110031#

metaR RE2541E
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: RE2541
fast: false

metaR S6T16g
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000

metaM ksi pre7 g
is: HMDB00175
notes: FORMULA: C115H187N8O85SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 7
has only substance units: false
is: C00130
initial amount: NaN
is: CHEBI:58053
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_29354b98_7684_4ddf_a3e4_4e0da0b54e12
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DPM2
constant: false
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000252

metaR GASNASE2ly
is version of: http://identifiers.org/ec-code/3.5.1.26
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
modifier: MODEL1310110031#

metaR PHEMEt
name: heme transport
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
reversible: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reactant: MODEL1310110031#
modifier: MODEL1310110031#

metaR DHEASULT
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is: SBO:0000176
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.8.2.14
name: Dehydroepiandrosterone sulfotransferase
fast: false
reactant: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.4

metaM accoa g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01206
has only substance units: false
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
boundary condition: false
is: CHEBI:57288
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_eb35d2a2_a1f2_45a4_969d_cbed70abde28
has part: Q9NS82
is encoded by: hsa:6520
is encoded by: hsa:56301
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC7A10:SLC3A2
is: SBO:0000297
has part: P08195
type: Species

metaM h m
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:24636
name: proton
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
constant: false
boundary condition: false
is: SBO:0000247

metaM 6hoxmelatn c
initial concentration: 1.0
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7954
has only substance units: false
constant: false
is: HMDB04081
is: C05643
name: 6-Hydroxymelatonin

metaM ps hs e
has only substance units: false
is: CHEBI:18303
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247
initial amount: NaN
name: phosphatidylserine

http://identifiers.org/biomodels.db/MODEL1310110031#_5af77b01_97e1_4181_986e_93347c08d600
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:85365
boundary condition: true
name: ALG2
initial concentration: NaN
is: Q9H553
type: Species
initial amount: NaN

metaM mercplac c
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: C05823
name: 3-Mercaptolactate
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02127
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8118

metaM mma c
initial concentration: 1.0
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00164
is: CHEBI:59338
name: methylammonium
boundary condition: false
type: Species
constant: false

metaM orn m
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: C01602
is: SBO:0000247
initial concentration: 1.0
is: HMDB00214
initial amount: NaN
name: Ornithine
has only substance units: false
is: CHEBI:46912
constant: false
type: Species

metaR IDOAASE4ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_0a50a4b6_b28f_4579_a4fa_efa1f1c3ffb5
name: PLCL1
constant: false
boundary condition: true
is: Q15111
is encoded by: hsa:5334
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_6404593e_b3a6_40f4_b120_3e98fa2e43c9
type: Species
boundary condition: true
initial amount: NaN
name: SLC17A1
initial concentration: NaN
is encoded by: hsa:6568
is: Q14916
has only substance units: false
constant: false
is: SBO:0000252

metaR r0839
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is: SBO:0000185
name: Postulated transport reaction
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.70

metaR STRDNCt
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110031#_4b15c4a7_3095_4e7d_a606_d94474eb9a1e
is: O75912
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:9162
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: DGKI

http://identifiers.org/biomodels.db/MODEL1310110031#_817e686f_1c07_407f_a610_0dfc1404dadb
name: SLC25A2
is encoded by: hsa:83884
initial concentration: NaN
constant: false
is: Q9BXI2
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_c11aa1e7_b5de_4707_927f_e5b55dd211df
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q92959
type: Species
boundary condition: true
name: SLCO2A1
initial concentration: NaN
is encoded by: hsa:6578
constant: false

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e9b923f3_d8ee_42f5_b207_fc1e5728f720
name: ALPL
has only substance units: false
type: Species
is encoded by: hsa:249
boundary condition: true
is: B7Z4Y6
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_f856b953_c0b3_4df2_81c9_a5e2ba345f9f
name: PLCXD2
is encoded by: hsa:257068
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q0VAA5
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_6cf8a7f0_c6dc_46b6_8123_1df2d38aa7af
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: GUCY1A2:GUCY1B3
is encoded by: hsa:2983
is encoded by: hsa:2977
initial concentration: NaN
has part: P33402
is: SBO:0000297
has part: Q02153
has only substance units: false

metaM dhea c
is: CHEBI:28689
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00077
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
name: 3beta-hydroxyandrost-5-en-17-one

http://identifiers.org/biomodels.db/MODEL1310110031#_4ee96737_e133_4be3_b743_1512455771f4
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:26275
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q6NVY1
name: HIBCH

metaR r0836
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
modifier: MODEL1310110031#
reversible: true
kinetic law: MODEL1310110031#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110031#

metaR S4TASE1ly
fast: false
is described by: ECO:0000000
modifier: MODEL1310110031#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_f165120f_e054_4c31_a5c2_046216505e8c
is encoded by: hsa:51166
is: Q8N5Z0
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false
name: AADAT
initial amount: NaN

metaR S6TASE8ly
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110031#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
fast: false
is: SBO:0000176
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal

metaR NACUP
fast: false
name: Nicotinic acid uptake
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR HMGCOAtm
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD

metaM guln c
initial concentration: 1.0
is: HMDB03290
is: CHEBI:13115
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
name: L-gulonate
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_3c521fb8_a022_413e_a13d_8dda1c3011d3
boundary condition: true
is encoded by: hsa:22978
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: P49902
initial amount: NaN
constant: false
name: NT5C2

metaR r0580
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
reversible: true
fast: false
modifier: MODEL1310110031#
is: SBO:0000176
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7

metaM txa2 r
initial concentration: 1.0
is: HMDB01452
type: Species
is: SBO:0000247
is: CHEBI:57445
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
name: thromboxane A2(1-)
initial amount: NaN
has only substance units: false

metaM 3odcoa m
name: 3-Oxodecanoyl-CoA
boundary condition: false
is: CHEBI:28528
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM ps hs c
name: ps_hs[c]
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaM dcsptn1 c
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
boundary condition: false
is: HMDB13123
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5282848
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false

metaR ALAASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110031#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110031#
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110031#
reversible: false
fast: false
modifier: MODEL1310110031#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_d5a93b70_5b7c_400e_84e7_65829138d0f8
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9057
name: SLC7A6
is: Q92536
constant: false
initial amount: NaN
is: SBO:0000252

metaR ASNALANaEx
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
product: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reactant: MODEL1310110031#

metaR MMSAD1m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.27
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
name: methylmalonate-semialdehyde dehydrogenase
reversible: false
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false

metaR FAOXC185m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR BACCL
reversible: false
is: SBO:0000176
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110031#
name: biotin-[acetyl-CoA-carboxylase] ligase
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110031#_91ba45f9_0a1b_400f_9e84_f043ad2929e0
name: OXSM
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:54995
constant: false
initial concentration: NaN
is: Q9NWU1
boundary condition: true

metaR GLYCtm
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000185
fast: false
name: glycerol transport
is described by: ECO:0000000

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR UMPK2
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000269
type: Reaction
name: UMP kinase (CTP)
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaM mi14p n
is: CHEBI:58282
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: HMDB00968

metaM co e
is: HMDB01361
constant: false
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: carbon monoxide
type: Species
has only substance units: false

metaM 3hdeccoa m
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcoa
type: Species
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB02288

metaR ACACT1x
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
product: MODEL1310110031#
fast: false
type: Reaction
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
reversible: false
reactant: MODEL1310110031#

metaR DMHPTCRNt
is: SBO:0000185
fast: false
reactant: MODEL1310110031#
name: 2,6 dimethylheptanoyl crn transport
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
product: MODEL1310110031#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_dcb60006_ab6e_4502_8e2a_214b643d2ec2
is encoded by: hsa:2645
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: GCK

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM dmhptcrn e
boundary condition: false
initial amount: NaN
is: HMDB06320
has only substance units: false
constant: false
type: Species
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR DM dttp m
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaM ksii core2 g
name: keratan sulfate II (core 2-linked)
is: HMDB01644
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
is: CHEBI:17140
constant: false

metaM nrvnc e
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: HMDB02368
name: nervonate
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:32392
has only substance units: false

metaR SO4tl
name: Sulfate transport (lysosome)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
reversible: true
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000185

metaM bilglcur r
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
constant: false
boundary condition: false

metaM ala B e
boundary condition: false
initial amount: NaN
is: CHEBI:16958
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
type: Species
is: HMDB00056
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR GALSIDEtl
kinetic law: MODEL1310110031#
name: galactocerebroside intracellular transport
type: Reaction
fast: false
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
reversible: true

metaM h r
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:24636
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0

metaM prostgf2 e
name: prostaglandin F2alpha(1-)
boundary condition: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
is: CHEBI:57404
constant: false
has only substance units: false
is: HMDB01139
initial concentration: 1.0
is: SBO:0000247

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
fast: false

metaR EX doco13ac
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR FAOXC160
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: Beta oxidation of long chain fatty acid

metaM 5adtststerone e
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
is: SBO:0000247
is: CHEBI:16330
initial concentration: 1.0

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110031#
type: Reaction
reversible: true
is: SBO:0000185

metaM sgalside hs c
type: Species
is: CHEBI:16523
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB03406
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_0de58a7d_eb95_48cb_a469_87a6fa39e7ca
name: PDE4B
is encoded by: hsa:5142
boundary condition: true
constant: false
is: SBO:0000252
is: Q5TEK5
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM guln r
is: HMDB03290
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
is: CHEBI:13115
type: Species
boundary condition: false
constant: false
has only substance units: false
name: L-gulonate
is: SBO:0000247

metaM gthrd m
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
name: glutathionate(1-)
type: Species
has only substance units: false
is: HMDB00125
initial concentration: 1.0
is: CHEBI:57925
constant: false
initial amount: NaN
is: SBO:0000247

metaR CYSALANaEx
modifier: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
fast: false

metaM CE0849 m
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57795
name: cis,cis-palmito-7,10-dienoyl-CoA

metaR DURAD
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
is: SBO:0000176

metaM CE2435 m
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247
is: CHEBI:57795
constant: false
name: trans,cis-deca-2,4-dienoyl-CoA
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_416a159e_66f1_4bca_a4b8_5cc84b7432c0
type: Species
is encoded by: hsa:23236
is: Q9NQ66
name: PLCB1
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM acngalgbside hs g
is: HMDB03406
type: Species
initial concentration: 1.0
constant: false
name: sialyl galactosylgloboside
is: SBO:0000247
boundary condition: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
initial amount: NaN
is: CHEBI:16523
has only substance units: false

metaM 3aib m
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: (S)-3-aminoisobutyric acid
is: HMDB02166
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
is: CHEBI:33094
constant: false

metaR MALtm
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false
reversible: true
type: Reaction
name: malate transport, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
is: CHEBI:26174
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110031#_87025032_1aa3_48cd_ae94_c8eefd996ea8
type: Species
is: SBO:0000252
name: RRM1
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6240
has only substance units: false
is: P23921

metaR RE2445E
is version of: http://identifiers.org/ec-code/3.4.17.23
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.15.1
name: RE2445

metaM CE1935 e
type: Species
initial amount: NaN
is: HMDB02329
is: CHEBI:30623
has only substance units: false
name: spermine monoaldehyde
initial concentration: 1.0
constant: false
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
boundary condition: false
is: SBO:0000247

metaM 5dhf e
has only substance units: false
initial amount: NaN
name: pentaglutamyl folate (DHF)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06487
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

metaM ksi deg17 l
boundary condition: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 17
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
type: Species
constant: false

metaR UMPK4
reversible: true
name: UMP kinase (GTP)
is: SBO:0000176
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_39ac439a_38f0_44f3_bebd_49273170fcb8
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2876
is: P07203
name: GPX1
boundary condition: true

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_30c67d15_a44f_48cc_b020_08f44f166571
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: P09972
type: Species
name: ALDOC
boundary condition: true
is encoded by: hsa:230
has only substance units: false

metaM ach n
is: HMDB00895
is: SBO:0000247
type: Species
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: acetylcholine

metaM tdec4ecoa m
is: C08277
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB00792
name: trans4decenoylcoa
initial concentration: 1.0
has only substance units: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR S6T15g
type: Reaction
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
kinetic law: MODEL1310110031#
is described by: ECO:0000000
modifier: MODEL1310110031#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
reversible: false
is: SBO:0000176

metaM ksii core2 e
constant: false
has only substance units: false
type: Species
is: CHEBI:17268
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked)

http://identifiers.org/biomodels.db/MODEL1310110031#_4176cc82_f813_4e4a_825e_521d3e2c8540
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q16698
is encoded by: hsa:1666
has only substance units: false
boundary condition: true
initial amount: NaN
name: DECR1

metaM amp m
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
name: AMP(2-)
constant: false
initial concentration: 1.0
is: CHEBI:456215
has only substance units: false
is: SBO:0000247

metaR r0149
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110031#
fast: false
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#

metaM hista e
is: CHEBI:58432
is: SBO:0000247
name: histamium
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00870
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false

metaM xoltetrol c
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
boundary condition: false
is: CHEBI:17278
initial amount: NaN
type: Species

metaR FAOXC163C164x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR RE0383C
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#
modifier: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
fast: false
reversible: true
name: RE0383

metaR UMPK3
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110031#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110031#
reversible: true
type: Reaction
name: UMP kinase (UTP)

http://identifiers.org/biomodels.db/MODEL1310110031#_62e83dd5_e26a_4e34_a3ff_024bb8186ca0
name: ALDH3A2
is: P51648
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:224

metaR FAOXC123C102x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR GALSIDEtg
type: Reaction
fast: false
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
product: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#
name: galactocerebroside intracellular transport
is described by: ECO:0000000
reversible: true

metaR MMEm
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/5.1.99.1
is: SBO:0000176
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110031#
fast: false
name: methylmalonyl-CoA epimerase/racemase
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110031#

metaR CITt4 4
is: SBO:0000185
name: citrate transport via sodium symport
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
type: Reaction
modifier: MODEL1310110031#
fast: false
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_39c0d081_15b7_4c55_b9bf_68003c9d0f53
is encoded by: hsa:2271
constant: false
has only substance units: false
initial amount: NaN
is: P07954
name: FH
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM ttdca e
initial concentration: 1.0
is: CHEBI:30807
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
has only substance units: false
is: HMDB00806
constant: false
is: C06424

metaM ksii core2 l
has only substance units: false
type: Species
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:17140
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01644
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_3a0088e6_a997_4e51_b1f9_9ff2875dd744
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _LOC727762_1_m
constant: false
is: SBO:0000252
is encoded by: hsa:LOC727762
type: Species

metaM odecrn c
boundary condition: false
initial concentration: 1.0
is: HMDB01114
name: octadecenoyl carnitine
initial amount: NaN
has only substance units: false
constant: false
is: C00412
is: CHEBI:57394
is: SBO:0000247
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1

metaM so4 l
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
is: SBO:0000247
is: HMDB01448
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16189
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_e30ed7ce_9309_422e_9a71_73befd9e1e80
is encoded by: hsa:9061
initial concentration: NaN
initial amount: NaN
name: PAPSS1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
is: O43252

metaM thmpp c
is: HMDB01372
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: C00068
boundary condition: false
name: Thiamine diphosphate
initial amount: NaN
is: SBO:0000247
is: CHEBI:45931

metaM xoldiolone c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28477
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
is: HMDB02197
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR r2344
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110031#
name: Organic anion transporter 5 Utilized transport

metaM orn e
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: Ornithine
is: HMDB00214
is: C01602
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:0

metaR ORNt3m
modifier: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport
product: MODEL1310110031#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110031#

metaR SPC HSt
reactant: MODEL1310110031#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
type: Reaction
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: sphingosylphosphorylcholine transport (diffusion)
is: SBO:0000185

metaM ksii core2 deg5 l
initial concentration: 1.0
is: HMDB00143
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:12936
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 5
initial amount: NaN

metaM citr L c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
type: Species
name: L-citrulline
initial concentration: 1.0
constant: false
has only substance units: false

metaR TMDPK
fast: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000176
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reactant: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.6.2

metaM hista c
name: histamium
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM 12ppd R c
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
boundary condition: false
is: CHEBI:28972
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01881
name: (R)-propane-1,2-diol

metaR ALAt2r
modifier: MODEL1310110031#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110031#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110031#
is described by: ECO:0000304
name: L-alanine reversible transport via proton symport
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_291f421c_6f35_4469_b9d0_a5456b576ea6
has part: P48201
type: Species
has only substance units: false
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:518
boundary condition: true
initial concentration: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110031#_791e9117_2b1c_49aa_ba2a_90ce6abcd2d1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:29925
name: GMPPB
constant: false
initial amount: NaN

metaM so4 m
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: CHEBI:16189
constant: false
name: sulfate
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01448
initial amount: NaN
type: Species

metaM ttdca c
initial concentration: 1.0
is: HMDB00806
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:30807
type: Species
is: SBO:0000247
name: myristate
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
boundary condition: false

metaR CITt4 2
is: SBO:0000185
modifier: MODEL1310110031#
name: citrate transport via sodium symport
product: MODEL1310110031#
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110031#_d9069aef_4f79_4e1c_a1ae_02def3bdac7a
type: Species
initial amount: NaN
name: _FLJ44968_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:FLJ44968
initial concentration: NaN
constant: false

metaR SBTD D2
modifier: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.14
reversible: false
fast: false
kinetic law: MODEL1310110031#
name: D-sorbitol dehydrogenase (D-fructose producing)

metaM 3htdcoa m
name: (S)-3-Hydroxytetradecanoyl-CoA
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
type: Species
constant: false
is: HMDB02288

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial concentration: 1.0
is: CHEBI:27485
boundary condition: false
constant: false
has only substance units: false
is: HMDB02710
type: Species
initial amount: NaN
name: Prostaglandin J2
is: SBO:0000247

metaR CMPACNAtn
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: CMP-Sia nuclear export
product: MODEL1310110031#
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_e1849d0f_703a_40ba_afa3_ab4a1e54f4ae
constant: false
has only substance units: false
name: ALDH6A1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4329
type: Species
initial concentration: NaN
is: Q02252

metaM 3docopencoa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaR LEUPHELAT2tc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_e2a11507_5772_4c56_a38a_030301e15f9e
initial amount: NaN
name: PDE4D
type: Species
is: Q08499
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5144
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_8850a020_1753_40eb_9d11_b945540daaa0
has only substance units: false
is: O75251
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFS7
is encoded by: hsa:374291
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_7ebf4004_a431_4903_911b_cf8ef311e9f6
has only substance units: false
name: GBA
is encoded by: hsa:2629
type: Species
initial concentration: NaN
is: B7Z6S1
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR CMPSASn
name: CMP sialic acid synthase, nuclear
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
reversible: false
modifier: MODEL1310110031#
type: Reaction

metaM orn c
is: SBO:0000247
is: CHEBI:0
is: C01602
is: HMDB00214
has only substance units: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
initial concentration: 1.0
name: Ornithine
type: Species
constant: false
initial amount: NaN

metaM co c
initial amount: NaN
is: HMDB01361
is: CHEBI:17245
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: carbon monoxide
type: Species
boundary condition: false
constant: false

metaR r2346
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110031#
type: Reaction
is: SBO:0000185
product: MODEL1310110031#

metaM dmhptcrn c
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: 2,6 dimethylheptanoyl carnitine
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
initial concentration: 1.0
is: HMDB06320
has only substance units: false

metaR r0033
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_22b9c6d6_4c90_47d7_aeeb_f1168dea4ed2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54963
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q53HM1
name: UCKL1
boundary condition: true

metaR r1401
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.3.1.51
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.7.10.1
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/3.2.1.35
product: MODEL1310110031#
reactant: MODEL1310110031#

metaR THRCYSNaEx
reactant: MODEL1310110031#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110031#
fast: false
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110031#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110031#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR IPDPtx
product: MODEL1310110031#
fast: false
kinetic law: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
is: SBO:0000185
is described by: ECO:0000134
name: Isopentenyl diphosphate transport (peroxisome)
type: Reaction
reactant: MODEL1310110031#

metaR M16NTg
is: SBO:0000176
type: Reaction
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110031#
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110031#

metaM citr L e
type: Species
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00904
initial concentration: 1.0
name: citr_L[e]
initial amount: NaN
is: CHEBI:16349

metaR ACACt2m
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
kinetic law: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
reactant: MODEL1310110031#

metaM nrvnc c
is: SBO:0000247
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
has only substance units: false
initial amount: NaN
name: nervonate
initial concentration: 1.0
type: Species
is: CHEBI:32392
is: HMDB02368
boundary condition: false
constant: false

metaR FORMCOAtx
name: formyl coa transport
is described by: ECO:0000000
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
reversible: true

metaR H6ET3er
modifier: MODEL1310110031#
type: Reaction
reversible: false
reactant: MODEL1310110031#
is: SBO:0000176
fast: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110031#
is described by: ECO:0000000
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.8.1

http://identifiers.org/biomodels.db/MODEL1310110031#_7a8b977f_f980_47cb_8d72_ad6e605bc3f1
is encoded by: hsa:93034
initial amount: NaN
is: Q96P26
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: NT5C1B
has only substance units: false
constant: false

metaR NOt
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185

metaM h x
is: SBO:0000247
type: Species
is: CHEBI:24636
initial concentration: 1.0
name: proton
is: http://identifiers.org/pubchem.compound/3380
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_249b6d89_5b4b_48e1_a2ce_bd7998bd93b7
initial concentration: NaN
name: MECR
type: Species
is: SBO:0000252
is encoded by: hsa:51102
constant: false
is: Q9BV79
has only substance units: false
boundary condition: true
initial amount: NaN

metaM hs deg25 l
boundary condition: false
notes: FORMULA: C23H37O21 CHARGE: -1
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false
constant: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110031#_88ec1bc7_a9b5_4aac_8f98_08441ed86813
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10637
has only substance units: false
initial amount: NaN
is: O75610
name: LEFTY1
constant: false

metaR PMTCOAtx
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
fast: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR UDPtl
name: udp intracellular transport
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
product: MODEL1310110031#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6265c24b_e0b1_4891_bdaa_70160356d742
is encoded by: hsa:8310
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: O15254
is: SBO:0000252
name: ACOX3
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_8ee3e30e_35ad_4742_a547_f3e776f07be4
constant: false
has part: P23921
is: SBO:0000297
has only substance units: false
is encoded by: hsa:6240
boundary condition: true
type: Species
initial amount: NaN
name: RRM1:RRM2
is encoded by: hsa:6241
initial concentration: NaN
has part: P31350

http://identifiers.org/biomodels.db/MODEL1310110031#_8eea047c_2f7d_42ee_9f92_abd6439a5fe7
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AV717590
boundary condition: true
constant: false
name: _AV717590_1_c
type: Species

metaM 3octdeccrn c
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB13336
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C25H49NO5 CHARGE: 0

metaM m4mpdol L c
initial concentration: 1.0
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
is: CHEBI:37633
has only substance units: false
type: Species
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
initial amount: NaN

metaR SGALSIDEtl
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: sgalside hs intracellular transport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110031#
is: SBO:0000185

metaM l2n2m2mn l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00143
has only substance units: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110031#_466882cd_67e0_4e76_9469_cee7efbdf107
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10005
constant: false
name: ACOT8
is: O14734
type: Species
boundary condition: true
initial concentration: NaN

metaM dmhptcrn m
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_27681703_085e_459e_b9b2_9aab2f9a6a20
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: E9PAY8
name: PPAP2C
has only substance units: false
is encoded by: hsa:8612
initial concentration: NaN

metaM amp r
is: C00020
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00045
name: AMP
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
boundary condition: false
initial amount: NaN

metaM 3aib c
initial amount: NaN
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
is: HMDB02166
is: CHEBI:33094
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR FAOXC5OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM txa2 c
name: thromboxane A2(1-)
is: CHEBI:57445
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01452
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaM itp e
is: HMDB00189
boundary condition: false
constant: false
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
type: Species
is: CHEBI:57614
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM txa2 e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57445
type: Species
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
is: HMDB01452
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_5822a346_fcdd_4afa_9ed2_33d5f0c1bc8d
initial concentration: NaN
initial amount: NaN
constant: false
name: SPHK2
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9NRA0
is encoded by: hsa:56848
type: Species

metaM ksi pre31 g
is: SBO:0000247
is: HMDB00175
constant: false
is: C00130
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 31
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaM c101crn e
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H31NO4 CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
name: decenoyl carnitine
boundary condition: false
is: HMDB13205

http://identifiers.org/biomodels.db/MODEL1310110031#_445a9486_f5f2_4e66_9923_5c432f209096
name: GALNT10
is: Q86SR1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55568
constant: false
type: Species
initial amount: NaN

metaR TXA2tr
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000185
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
name: thromboxane A2 intracellular transport
reversible: true
product: MODEL1310110031#
fast: false

metaR NACHEX10ly
modifier: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110031#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is described by: ECO:0000000

metaM ahcys m
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
has only substance units: false
name: S-Adenosyl-L-homocysteine
boundary condition: false
constant: false
is: C00021
is: HMDB00939
is: SBO:0000247
initial amount: NaN
type: Species

metaM ala B m
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16958
is: HMDB00056

metaM gthrd e
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
constant: false
boundary condition: false
is: HMDB00125
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: glutathionate(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_930780ea_9db0_41dc_af6a_25da88150a1f
is: SBO:0000252
boundary condition: true
is: B2RAU6
type: Species
is encoded by: hsa:9091
name: PIGQ
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_85a6525c_a743_4e4c_b844_f654e1c1e7b9
is: P42126
is encoded by: hsa:1632
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ECI1
boundary condition: true

metaM kynate c
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247
name: kynurenate
boundary condition: false
is: CHEBI:58454
is: HMDB00715
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_efb4c8d8_fcf7_416b_b626_607e26a94ea1
constant: false
is encoded by: hsa:6553
name: SLC9A5
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9NSW9
initial concentration: NaN
type: Species
has only substance units: false

metaR r1512
is described by: ECO:0000000
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000185
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_fcaeccca_2729_4836_9e19_bc697d763ae1
constant: false
has only substance units: false
is encoded by: hsa:7355
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: SLC35A2
is: P78381

metaM ins c
type: Species
is: C00294
constant: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: CHEBI:17596
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Inosine
is: HMDB00195

metaR r0142
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110031#
reversible: false
reactant: MODEL1310110031#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM cspg b l
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:36005
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
initial concentration: 1.0
is: HMDB02183
constant: false

metaM 3octdeccrn e
initial amount: NaN
notes: FORMULA: C25H49NO5 CHARGE: 0
name: 3-hydroxyoctadecanoyl carnitine
is: HMDB13336
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR APAT2rm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000212
is: SBO:0000176
fast: false
modifier: MODEL1310110031#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110031#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
product: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR MM6B2g
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110031#
product: MODEL1310110031#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaM 2mp2coa m
name: 2-Methylprop-2-enoyl-CoA
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
has only substance units: false
is: HMDB01011
is: CHEBI:27754
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM itp c
boundary condition: false
is: SBO:0000247
is: HMDB00189
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
constant: false
type: Species
is: CHEBI:57614
initial concentration: 1.0
initial amount: NaN

metaM dhap m
name: Dihydroxyacetone phosphate
is: HMDB01473
boundary condition: false
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3411
initial concentration: 1.0
is: C00111
initial amount: NaN
is: SBO:0000247

metaM 3aib e
name: (S)-3-aminoisobutyric acid
constant: false
is: HMDB02166
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_6c5a53a5_489c_4249_a338_fcb12b34c3a4
is encoded by: hsa:4724
initial concentration: NaN
name: NDUFS4
type: Species
has only substance units: false
initial amount: NaN
is: O43181
boundary condition: true
constant: false
is: SBO:0000252

metaM c101crn c
is: HMDB13205
type: Species
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
boundary condition: false
name: decenoyl carnitine
constant: false
is: SBO:0000247

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_36fbc265_1806_4f14_b445_aaabb1e5a75f
has part: B4DY56
constant: false
initial amount: NaN
is encoded by: hsa:498
is: SBO:0000297
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
type: Species
has only substance units: false

metaR CYTK9n
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110031#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_7dc736a7_98d8_46cd_8190_a48a19081131
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:55191
is: Q6IA69
name: NADSYN1
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM gthrd c
boundary condition: false
is: CHEBI:57925
constant: false
name: Reduced glutathione
is: C00051
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
has only substance units: false
is: HMDB00125
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_23a3742d_99b2_4d50_8550_917a86a23ee0
initial amount: NaN
is encoded by: hsa:80308
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: FLAD1
has only substance units: false
initial concentration: NaN

metaR r2060
kinetic law: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110031#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110031#_c71b9c5c_9961_4c92_b839_c531abb119d7
initial amount: NaN
is: P23378
is: SBO:0000252
is encoded by: hsa:2731
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: GLDC

http://identifiers.org/biomodels.db/MODEL1310110031#_38a78ccf_356a_4992_af63_1185e3723d35
constant: false
is encoded by: hsa:5277
initial amount: NaN
has part: P37287
is encoded by: hsa:8818
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ca434ed0_c4e2_4bd0_83c3_a51f02b32d88
name: SLC22A2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6582
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR RE3272N
kinetic law: MODEL1310110031#
is: SBO:0000176
fast: false
name: RE3272
reversible: true
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a9366ef1_5a0b_45a2_8d67_af173b73e084
is: Q7Z4W1
name: DCXR
initial concentration: NaN
is encoded by: hsa:51181
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM citr L m
is: HMDB00904
type: Species
is: CHEBI:16349
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
name: L-citrulline
initial amount: NaN
boundary condition: false

metaM ins e
is: HMDB00195
type: Species
has only substance units: false
is: CHEBI:17596
is: C00294
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false
initial amount: NaN
initial concentration: 1.0
name: Inosine

metaR RE3005M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is described by: ECO:0000000
name: RE3005
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_a2065e0e_2d8f_4325_bc4f_f27562e907fc
is encoded by: hsa:AGPAT7
initial concentration: NaN
name: _AGPAT7_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR GCCcm
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110031#
modifier: MODEL1310110031#
reversible: true

metaR O2St
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110031#
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110031#

metaR G14T3g
kinetic law: MODEL1310110031#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110031#
reactant: MODEL1310110031#
reversible: false
is described by: ECO:0000000

metaR SGALSIDEtg
is: SBO:0000185
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: sgalside hs intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110031#_5327c125_aa17_494a_baa2_23765fb0faae
has only substance units: false
is: P10696
is: SBO:0000252
boundary condition: true
is encoded by: hsa:251
initial amount: NaN
type: Species
name: ALPPL2
constant: false
initial concentration: NaN

metaR FTCD
name: formimidoyltransferase cyclodeaminase
fast: false
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is version of: http://identifiers.org/ec-code/2.1.2.5
reversible: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
initial amount: NaN
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB00143
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_397273e9_4109_4a1f_877d_0a5af3f8f41e
name: ALDH2
is encoded by: hsa:217
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P05091
boundary condition: true

metaR r1847
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110031#
is: SBO:0000185
modifier: MODEL1310110031#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_bb66d473_53f6_4db3_bc65_a1e0f72720d7
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:122970
type: Species
initial concentration: NaN
boundary condition: true
name: ACOT4
is: Q8N9L9
constant: false

metaR GLYCLTtp
fast: false
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: glycolate transport into peroxisome
is: SBO:0000185

metaM dmnoncrn m
is: HMDB06202
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
name: 4,8 dimethylnonanoyl carnitine

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM odecrn m
type: Species
name: octadecenoyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
boundary condition: false
initial amount: NaN
is: CHEBI:57394
is: SBO:0000247
is: HMDB01114
constant: false
initial concentration: 1.0
has only substance units: false
is: C00412

http://identifiers.org/biomodels.db/MODEL1310110031#_b8205cd3_127b_406e_9466_0e270ea57859
type: Species
name: MAOB
is: SBO:0000252
is encoded by: hsa:4129
constant: false
initial amount: NaN
initial concentration: NaN
is: P27338
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_c93db960_40e5_4c27_94f4_2748d9ff9af7
is encoded by: hsa:4882
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NPR2

http://identifiers.org/biomodels.db/MODEL1310110031#_270143b4_7a40_4f68_98ad_e30602a6de0e
initial amount: NaN
is encoded by: hsa:84002
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: B3GNT5
is: Q9BYG0
initial concentration: NaN
constant: false

metaR RE2625C
reversible: true
kinetic law: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE2625
reactant: MODEL1310110031#
fast: false
is described by: ECO:0000000
product: MODEL1310110031#
is: SBO:0000176

metaR FAOXC161C141x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR GTHRDt
type: Reaction
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reversible: true
name: Glutathione transport into mitochondria
is: SBO:0000185
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.

http://identifiers.org/biomodels.db/MODEL1310110031#_3c8f7875_27b6_4035_8a28_bb306d522cd9
is encoded by: hsa:223
type: Species
is: SBO:0000252
name: ALDH9A1
initial amount: NaN
is: P49189
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a7faa211_d697_4619_ae5c_e89510d14154
constant: false
name: SUCLA2
boundary condition: true
is: E5KS60
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8803
initial amount: NaN
is: SBO:0000252
type: Species

metaM mi1345p c
boundary condition: false
constant: false
is: CHEBI:57895
is: SBO:0000247
is: HMDB01059
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
has only substance units: false
type: Species
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_47ff2881_fd79_4dc9_9983_8802324951fd
initial concentration: NaN
is: SBO:0000252
name: GALNT10
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:55568

http://identifiers.org/biomodels.db/MODEL1310110031#_703a4b71_f80e_469d_8941_a49eb356db14
initial amount: NaN
type: Species
has only substance units: false
is: P20674
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: COX5A
constant: false
is encoded by: hsa:9377

http://identifiers.org/biomodels.db/MODEL1310110031#_2cc55ed7_6774_4a70_872d_f83aa96d290d
initial concentration: NaN
constant: false
is: Q86U05
is encoded by: hsa:23428
is: SBO:0000252
name: SLC7A8
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR FAOXC123C102m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR RE1233C
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110031#
reactant: MODEL1310110031#
name: RE1233

metaM ttetddcoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB02288

metaR SQLSr
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
fast: false
name: Squalene synthase
is described by: ECO:0000134
reversible: false
product: MODEL1310110031#
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.5.1.21

http://identifiers.org/biomodels.db/MODEL1310110031#_e16a6e3d_0ef9_491e_a173_7350b5d4e6cd
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: O95864
is encoded by: hsa:9415
name: FADS2
is: SBO:0000252
initial amount: NaN

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR SIAASE3ly
modifier: MODEL1310110031#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: false
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110031#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110031#

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
has only substance units: false
initial amount: NaN
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
type: Species
is: CHEBI:57404
is: HMDB01139
is: SBO:0000247
boundary condition: false

metaM succoa m
boundary condition: false
is: CHEBI:57292
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
name: Succinyl-CoA
type: Species
constant: false
is: HMDB01022
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM tetdec2coa c
constant: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: tetradecadienoylcoa
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB02014

metaR r0145
kinetic law: MODEL1310110031#
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reversible: true
product: MODEL1310110031#
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110031#

metaR r2064
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
modifier: MODEL1310110031#
product: MODEL1310110031#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_9a6671b9_2e7f_44c6_8de4_852d9c515494
boundary condition: true
initial amount: NaN
constant: false
is: Q9ULC5
has only substance units: false
initial concentration: NaN
name: ACSL5
is: SBO:0000252
is encoded by: hsa:51703
type: Species

metaR FAOXC150m
reversible: false
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is described by: ECO:0000269
is: SBO:0000176
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110031#
type: Reaction

metaR THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is described by: ECO:0000000
product: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110031#
reversible: true

metaR NRVNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110031#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110031#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110031#

metaM 5adtststerone c
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: CHEBI:16330
initial concentration: 1.0
boundary condition: false
is: HMDB02961
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN

metaR UGCG
reversible: false
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
modifier: MODEL1310110031#
name: Ceramide glucosyltransferase
is described by: ECO:0000000
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.4.1.80

metaR RETNt
product: MODEL1310110031#
fast: false
type: Reaction
kinetic law: MODEL1310110031#
reversible: true
is: SBO:0000185
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
name: retinoic acid transport
is described by: ECO:0000000

metaR ACGBGBSIDEtg
type: Reaction
fast: false
kinetic law: MODEL1310110031#
reversible: true
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: acgbgbside hs intracellular transport
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_f2a0831a_841c_4448_9622_4c0d429c6333
is: P19404
constant: false
initial concentration: NaN
name: NDUFV2
boundary condition: true
is encoded by: hsa:4729
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR SERPT
is version of: http://identifiers.org/ec-code/2.3.1.50
fast: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110031#
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#
name: serine C-palmitoyltransferase
type: Reaction
is: SBO:0000176

metaM m1mpdol U c
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:28067
constant: false

metaM bilirub c
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57977
boundary condition: false
name: bilirubin(2-)
initial concentration: 1.0
constant: false
type: Species

metaR C161CRN2t
reactant: MODEL1310110031#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110031#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110031#
product: MODEL1310110031#
name: C161 transport into the mitochondria

metaM xyl D c
initial amount: NaN
constant: false
name: aldehydo-D-xylose
is: SBO:0000247
has only substance units: false
is: CHEBI:15936
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaM CE5868 e
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
is: SBO:0000247
name: N-acetyl-seryl-aspartate
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02710
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:27485

metaR r1380
type: Reaction
reactant: MODEL1310110031#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72

metaR r1538
type: Reaction
fast: false
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110031#
product: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
reversible: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8

metaR TCHOLAte
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reactant: MODEL1310110031#
reversible: true
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110031#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_a098c41a_3290_49ad_976d_ec9794c6ed5c
constant: false
initial amount: NaN
is: Q96RQ3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:56922
name: MCCC1

metaM g1m8mpdol L r
is: C05870
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
constant: false
initial amount: NaN
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM prist x
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:51340
is: SBO:0000247
name: pristanic acid
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110031#_1213957b_bf29_4dd4_94d7_f1896dd897d3
is encoded by: hsa:8854
boundary condition: true
is: B4DZR2
name: ALDH1A2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM dd2coa c
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
constant: false
initial concentration: 1.0

metaR RE2626M
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
name: RE2626
reactant: MODEL1310110031#
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR C12OHc
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM dttp e
is: HMDB01342
initial amount: NaN
constant: false
initial concentration: 1.0
name: dTTP(4-)
is: CHEBI:37568
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM adp r
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
is: SBO:0000247
is: HMDB01341
initial concentration: 1.0
name: ADP(3-)
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:456216
initial amount: NaN

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR DOLGPP Ler
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110031#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110031#

metaM ksi e
initial amount: NaN
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
constant: false
name: keratan sulfate I
is: CHEBI:17268
is: HMDB00211
boundary condition: false
is: SBO:0000247
type: Species

metaR PMANM
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
name: phosphomannomutase
modifier: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.8
fast: false

metaM bilirub e
is: CHEBI:57977
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
is: HMDB00054
is: SBO:0000247
initial concentration: 1.0

metaM ksi g
initial amount: NaN
is: CHEBI:17140
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01644
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
type: Species

metaR FAOXC225C226x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_11e5bf21_89b7_4f79_b382_641011e64c28
name: RRM1
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6240
is: P23921
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_e170fc81_75ab_4d34_858c_e092538c994d
has only substance units: false
is encoded by: hsa:55825
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: Q9BY49
name: PECR

metaM xyl D e
is: SBO:0000247
name: aldehydo-D-xylose
is: CHEBI:15936
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false

metaM cs a deg1 l
is: SBO:0000247
is: HMDB01354
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110031#_56640952_c94c_4489_8f20_858823cea7b0
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P54709
is: SBO:0000252
name: ATP1B3
initial amount: NaN
is encoded by: hsa:483
type: Species

metaR DMATTx
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
is described by: ECO:0000134
reactant: MODEL1310110031#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR LCADi
reactant: MODEL1310110031#
product: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is described by: ECO:0000304
name: lactaldehyde dehydrogenase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: HMDB00972
has only substance units: false
constant: false
is: CHEBI:57454
is: C00234
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
type: Species
is: SBO:0000247
initial amount: NaN

metaR ACGALtlg
reactant: MODEL1310110031#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
name: N-acetyl-galactosamine intracellular transport
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reversible: true

metaM dttp c
name: dTTP
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species
initial concentration: 1.0
is: HMDB01342
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM 1pyr5c c
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
boundary condition: false
is: C03912
is: HMDB01301
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_8d098fb2_aea2_494d_a9ed_0eefcad91aa0
type: Species
has only substance units: false
is: Q9H0N5
constant: false
is encoded by: hsa:84105
initial concentration: NaN
initial amount: NaN
name: PCBD2
is: SBO:0000252
boundary condition: true

metaR THRSERNaEx
kinetic law: MODEL1310110031#
type: Reaction
is described by: ECO:0000269
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110031#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110031#
modifier: MODEL1310110031#

metaR r1381
product: MODEL1310110031#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: true
reactant: MODEL1310110031#
is described by: ECO:0000000

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM idour l
is: HMDB02704
name: L-iduronate
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:21338
is: SBO:0000247

metaM g3m8masn r
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
is: C05873
initial concentration: 1.0

metaM dec24dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: HMDB01168
name: 2,4-decadienoylcoa
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247

metaM dag hs r
type: Species
initial concentration: 1.0
is: CHEBI:18035
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR AG13T7g
type: Reaction
product: MODEL1310110031#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110031#
is described by: ECO:0000000
reactant: MODEL1310110031#
is: SBO:0000176
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM ksi pre3 g
initial concentration: 1.0
is: HMDB00175
is: C00130
type: Species
constant: false
is: CHEBI:58053
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 3

metaM 3hodcoa c
is: HMDB13336
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: SBO:0000247

metaM val L e
is: CHEBI:16414
has only substance units: false
constant: false
initial concentration: 1.0
name: L-valine
boundary condition: false
is: HMDB00883
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaM retinal cis 13 r
is: HMDB06220
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:45487
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
initial concentration: 1.0

metaR CBR2
product: MODEL1310110031#
fast: false
name: Carbonyl reductase [NADPH] 1
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
is version of: http://identifiers.org/ec-code/1.1.1.189
modifier: MODEL1310110031#
reversible: false
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000269

metaR TYRTA
kinetic law: MODEL1310110031#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110031#
type: Reaction
reactant: MODEL1310110031#
is: SBO:0000176
name: tyrosine transaminase
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_29b312e6_fd20_4810_9755_941dc9c37a45
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1384
name: CRAT
type: Species
initial amount: NaN

metaM 3htdcoa c
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB02014
type: Species
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA

metaR FAOXC12C10m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR r1384
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110031#
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110031#_c176ffd2_54eb_49e4_9239_ef0c6e7f4c02
type: Species
initial concentration: NaN
name: LDHC
is encoded by: hsa:3948
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: CHEBI:16094
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
has only substance units: false
is: HMDB00257
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ac5b13fa_add5_43bb_9c45_74e297490aef
name: LPGAT1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:9926
is: SBO:0000252
constant: false
is: Q92604
initial concentration: NaN
has only substance units: false

metaR r0860
modifier: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110031#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reversible: true
name: Utilized transport
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:

metaR ACGBGBSIDEtl
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110031#
fast: false
reactant: MODEL1310110031#
name: acgbgbside hs intracellular transport
reversible: true
is described by: ECO:0000000

metaM odecoa c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:3793
initial amount: NaN
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR GBSIDEtl
type: Reaction
kinetic law: MODEL1310110031#
name: globoside intracellular transport
reactant: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

metaM xol7ah2al m
is: HMDB06894
has only substance units: false
constant: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: CHEBI:27428
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM thr L c
is: CHEBI:16857
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00167
name: L-threonine
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false

metaR FACOAL160i
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110031#
product: MODEL1310110031#
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
reactant: MODEL1310110031#
is described by: ECO:0000269
name: C160 fatty acid activation

metaM pristcoa x
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: pristanoyl coa
is: CHEBI:51341

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM core6 l
name: Core 6
initial amount: NaN
constant: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00143

metaR r1693
type: Reaction
is: SBO:0000185
reactant: MODEL1310110031#
modifier: MODEL1310110031#
product: MODEL1310110031#
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110031#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110031#_069905a3_5755_493f_abc8_a93ea51ce970
name: CPT1B
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1375
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q53FV7

metaR DLNLCGCPT2
reversible: false
is: SBO:0000176
name: carnitine transferase
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110031#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110031#
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110031#_d5ba6609_4ba6_4fe7_9a8b_3dedaf9c025c
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR C3STDH1Pr
fast: false
product: MODEL1310110031#
reactant: MODEL1310110031#
type: Reaction
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
modifier: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_84d4ac2e_ddb3_4bbf_926b_43a91ae0fda2
boundary condition: true
constant: false
is: Q5SYN6
initial amount: NaN
is: SBO:0000252
name: SLC22A3
has only substance units: false
is encoded by: hsa:6581
type: Species
initial concentration: NaN

metaM vacccrn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: HMDB06351
constant: false
type: Species
has only substance units: false
name: Vaccenyl carnitine
is: SBO:0000247

metaM adp x
constant: false
name: ADP(3-)
is: SBO:0000247
initial amount: NaN
is: HMDB01341
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110031#_b21a427a_1f30_4981_b049_d1c9d4a64c51
type: Species
initial amount: NaN
is encoded by: hsa:314
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: AOC2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110031#_491929b0_2795_4a54_b7ed_252087ce4e4e
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DBT
is: P11182
initial amount: NaN
is encoded by: hsa:1629

metaR PRODt2r
kinetic law: MODEL1310110031#
modifier: MODEL1310110031#
is: SBO:0000185
product: MODEL1310110031#
is described by: ECO:0000304
fast: false
name: D-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
reversible: true
reactant: MODEL1310110031#
type: Reaction

metaR DLNLCGCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110031#
fast: false
modifier: MODEL1310110031#
type: Reaction
product: MODEL1310110031#
kinetic law: MODEL1310110031#
name: carnitine O-palmitoyltransferase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110031#_e5dfedca_a74e_43d1_932e_512282dd3950
is: Q16739
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7357
has only substance units: false
name: UGCG
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaR SUCCtp
reversible: true
fast: false
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000000
is: SBO:0000185
name: succinate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17759
boundary condition: false
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM thr L e
is: HMDB00167
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:16857
name: L-threonine

http://identifiers.org/biomodels.db/MODEL1310110031#_57c362f9_68be_442d_b8ab_06918ce9c7b2
is: SBO:0000252
is: O15357
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: INPPL1
is encoded by: hsa:3636
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_ea1ea83d_eb92_4cdb_a20a_bf223c289ab1
is: SBO:0000252
boundary condition: true
name: LDHB
is encoded by: hsa:3945
initial amount: NaN
type: Species
has only substance units: false
is: P07195
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110031#_35fbf47d_cdd0_4129_b6ae_bb04fc17489f
is: O75912
has only substance units: false
is encoded by: hsa:9162
name: DGKI
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaR RE2666C
reactant: MODEL1310110031#
is: SBO:0000176
type: Reaction
name: RE2666
reversible: false
is described by: ECO:0000000
product: MODEL1310110031#
kinetic law: MODEL1310110031#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:

metaM amet c
is: SBO:0000247
name: S-Adenosyl-L-methionine
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
is: HMDB01185
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: C00019
is: CHEBI:15414

http://identifiers.org/biomodels.db/MODEL1310110031#_15900968_af0a_4e61_aaa2_68d1e8ea5e21
type: Species
name: ADO
boundary condition: true
is: B3KXN9
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:84890

metaM dag hs n
is: CHEBI:18035
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: diglyceride

metaM HC02204 c
is: CHEBI:27624
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: prostaglandin-b1
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_ccaeac94_7883_4a8f_92d0_01310bdf67ce
name: MTHFS
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P49914
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:10588

metaM ala B c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: beta-alanine
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16958
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056

metaR FAOXC227C226m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR ACGPID
modifier: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.1.89
product: MODEL1310110031#
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is described by: ECO:0000269
kinetic law: MODEL1310110031#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reactant: MODEL1310110031#

metaR 5MTHFt
is: SBO:0000185
product: MODEL1310110031#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110031#
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110031#
reversible: true

metaM tststerones e
boundary condition: false
initial concentration: 1.0
name: testosterone sulfate
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
initial amount: NaN
type: Species
is: HMDB02833

metaR DESAT18 8
type: Reaction
modifier: MODEL1310110031#
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reversible: false
kinetic law: MODEL1310110031#
is described by: ECO:0000269
reactant: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_9fd9c6bf_89d8_4277_806e_6bba1abbd6a5
constant: false
type: Species
boundary condition: true
is: P30043
name: BLVRB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:645
is: SBO:0000252
initial amount: NaN

metaM akg e
initial amount: NaN
name: 2-oxoglutarate(2-)
has only substance units: false
is: HMDB00208
constant: false
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: CHEBI:16810
boundary condition: false
is: SBO:0000247

metaR r0591
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110031#
product: MODEL1310110031#
fast: false
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110031#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
product: MODEL1310110031#
is described by: ECO:0000269
modifier: MODEL1310110031#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110031#
kinetic law: MODEL1310110031#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM drib c
boundary condition: false
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN
is: HMDB03224
constant: false
name: 2-deoxy-D-ribose
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:28816

http://identifiers.org/biomodels.db/MODEL1310110031#_0f9575c5_85d5_4940_af97_cef0e6f30296
name: MTMR2
is encoded by: hsa:8898
type: Species
constant: false
has only substance units: false
boundary condition: true
is: A6NN98
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaM amet m
is: CHEBI:15414
constant: false
boundary condition: false
has only substance units: false
is: HMDB01185
is: SBO:0000247
initial concentration: 1.0
type: Species
name: S-Adenosyl-L-methionine
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019

http://identifiers.org/biomodels.db/MODEL1310110031#_c9aaa46a_f592_450a_a8d3_4bc9c342f80b
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:4705
is: O95299
has only substance units: false
name: NDUFA10
is: SBO:0000252
boundary condition: true
constant: false

metaM vacccrn m
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Vaccenyl carnitine
constant: false
is: HMDB06351
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110031#_e49c4eb2_e853_4170_973f_5d888e444c4e
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:79053
initial concentration: NaN
is: Q9BVK2
boundary condition: true
constant: false
is: SBO:0000252
name: ALG8

http://identifiers.org/biomodels.db/MODEL1310110031#_9ce36789_fbd5_4d57_9099_afff28d1d04c
is encoded by: hsa:NOS2A
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: _NOS2A_1_e
initial amount: NaN
has only substance units: false

metaR FAOXC225C204m
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR SIAASE2ly
product: MODEL1310110031#
fast: false
is described by: ECO:0000000
type: Reaction
name: sialidase, lysosomal
modifier: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110031#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR GLUTCOAACBP
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR GASNASEly
product: MODEL1310110031#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110031#
reactant: MODEL1310110031#
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110031#
reversible: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110031#_282c58de_ce11_4815_8371_07b0f1ad3d60
initial concentration: NaN
type: Species
constant: false
name: PIGW
is: Q7Z7B1
is encoded by: hsa:284098
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM HC02204 e
boundary condition: false
is: CHEBI:27624
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
initial amount: NaN
name: prostaglandin-b1
type: Species
has only substance units: false

metaR GLCNACT U
kinetic law: MODEL1310110031#
fast: false
product: MODEL1310110031#
reversible: false
type: Reaction
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
is: SBO:0000176
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000

metaM xylu D c
has only substance units: false
name: D-xylulose
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17140
is: SBO:0000247
is: HMDB01644
boundary condition: false
type: Species

metaM val L c
boundary condition: false
type: Species
name: L-valine
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
is: HMDB00883
initial concentration: 1.0

metaM tststerones c
type: Species
initial concentration: 1.0
name: testosterone sulfate
is: HMDB02833
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR CHATn
name: Choline O-acetyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110031#
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
product: MODEL1310110031#
kinetic law: MODEL1310110031#
is: SBO:0000176
reactant: MODEL1310110031#
type: Reaction

metaM idour c
constant: false
is: CHEBI:21338
initial amount: NaN
name: L-iduronate
boundary condition: false
is: HMDB02704
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
type: Species

metaM ethamp c
constant: false
name: ethamp[c]
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00224
type: Species
is: CHEBI:58190
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110031#_b79f9196_2b18_4549_a1d8_7f60df7564ea
name: _AU149534_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AU149534
initial amount: NaN
boundary condition: true

metaM drib e
has only substance units: false
is: HMDB03224
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
name: 2-deoxy-D-ribose
is: CHEBI:28816
initial concentration: 1.0

metaM prostgi2 e
type: Species
is: CHEBI:57403
has only substance units: false
is: SBO:0000247
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
initial concentration: 1.0
is: HMDB01335
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110031#_424c0654_702d_453e_9d90_370197a9b40b
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7915
name: ALDH5A1
type: Species
boundary condition: true
is: Q546H9
constant: false

metaR FORtr
reactant: MODEL1310110031#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
reversible: true
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110031#
type: Reaction
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_46b69e35_0b65_486c_bdc4_4dd06a5205aa
name: BCKDHA
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: B4DP47
is encoded by: hsa:593
type: Species

metaR CYSGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110031#
product: MODEL1310110031#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110031#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110031#

http://identifiers.org/biomodels.db/MODEL1310110031#_20019bfe_7ab8_4d6e_ac60_910a25cdbf62
name: AMACR
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q3KT79
type: Species
initial concentration: NaN
is encoded by: hsa:23600
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110031#_318db3f3_0950_4a7a_b4df_aa606561cef5
type: Species
name: ACOX2
initial amount: NaN
is: SBO:0000252
is: Q99424
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8309

metaR r0590
reactant: MODEL1310110031#
type: Reaction
modifier: MODEL1310110031#
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
fast: false
product: MODEL1310110031#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110031#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110031#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
constant: false
is: CHEBI:61648
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: VI2Fuc-nLc6
boundary condition: false
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0

metaR FAOXC81C61x
kinetic law: MODEL1310110031#
product: MODEL1310110031#
reactant: MODEL1310110031#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110031#_6b568adc_647e_414a_aa4c_300a1b211761
has only substance units: false
name: NDUFA4
is: SBO:0000252
is encoded by: hsa:4697
is: O00483
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM amp e
boundary condition: false
name: AMP
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00020
is: CHEBI:456215
is: HMDB00045
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false