metaR r1365
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#
name: Vesicular transport
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaR FAOXC181C161m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR FRDPtcr
is described by: ECO:0000134
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
fast: false

metaR FAOXC180
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110030#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110030#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_a5173a28_5898_427b_afbf_84e85c19452e
constant: false
name: SLC16A10
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:117247
is: Q8TF71
initial concentration: NaN
type: Species
boundary condition: true

metaM triodthy e
type: Species
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
constant: false
has only substance units: false
is: HMDB00265
initial amount: NaN
boundary condition: false
is: CHEBI:18258

http://identifiers.org/biomodels.db/MODEL1310110030#_0ff889d0_81ff_4fb3_bded_13a1d2a17596
is encoded by: hsa:10201
name: NME6
is: O75414
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM mhista c
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58600
is: HMDB00898
boundary condition: false
constant: false
name: N(tele)-methylhistaminium
has only substance units: false
initial amount: NaN

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
product: MODEL1310110030#
fast: false

metaR S6T8g
modifier: MODEL1310110030#
reversible: false
fast: false
kinetic law: MODEL1310110030#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_48c3f2ae_22dd_4453_9223_c96a56c47f79
is: SBO:0000252
is: P04180
is encoded by: hsa:3931
name: LCAT
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR NAHCO3 HCLt
kinetic law: MODEL1310110030#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185
reversible: true
name: bicarbonate transport (HCl/NaHCO3 exchange)
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM rnam c
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
type: Species
is: CHEBI:15927
is: SBO:0000247
initial concentration: 1.0
is: HMDB00855
constant: false
has only substance units: false
name: N-Ribosylnicotinamide

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000269

metaM tststerone r
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00234
name: testosterone
boundary condition: false

metaM ptrc c
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:326268
is: HMDB01414
has only substance units: false
type: Species
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine

metaR HSAT2ly
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_335716f4_8ac6_4883_b6e4_7c95244bd5b1
constant: false
name: ACADVL
initial amount: NaN
is encoded by: hsa:37
is: P49748
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM pe hs e
boundary condition: false
is: CHEBI:16038
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_6f92b675_14b8_4309_b737_e45b1a5c5fbd
name: TPI1P2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:286016
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_d4c12cbe_5b28_4078_bfe6_2eea0402785a
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: Q92536
name: SLC3A2:SLC7A6
is encoded by: hsa:9057
has only substance units: false
constant: false
is: SBO:0000297
type: Species

metaR S6TASE18ly
product: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
is: SBO:0000176

metaR CTPtn
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reversible: true
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
type: Reaction
name: CTP diffusion in nucleus

http://identifiers.org/biomodels.db/MODEL1310110030#_817e44f2_c340_4df5_a0f7_8599d3673088
is encoded by: hsa:6509
constant: false
initial concentration: NaN
boundary condition: true
name: SLC1A4
initial amount: NaN
is: P43007
type: Species
has only substance units: false
is: SBO:0000252

metaM 44mzym r
type: Species
is: CHEBI:18364
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
name: 14-demethyllanosterol
initial concentration: 1.0
is: HMDB01286

metaR r0715
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000

metaR M4MPDOL Lter
reversible: false
type: Reaction
name: m4mpdol flippase
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_867b0818_d818_4c8e_b94f_b512db54f800
type: Species
is encoded by: hsa:AI653169
name: _AI653169_1_c
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR ALAt2r
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110030#
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_f272305d_c00c_4bd3_9625_8e92f38c12b0
is: SBO:0000252
is: P23219
is encoded by: hsa:5742
constant: false
has only substance units: false
initial amount: NaN
name: PTGS1
initial concentration: NaN
boundary condition: true
type: Species

metaM 3hpp m
name: 3-hydroxypropionate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00700
is: CHEBI:16510
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
type: Species
is: SBO:0000247
has only substance units: false

metaR FUCtly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
fast: false
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
name: L-fucose efflux from lysosome
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000185

metaR r1648
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM strdnccoa m
is: SBO:0000247
initial concentration: 1.0
is: C16163
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
name: stearidonyl coenzyme A
constant: false
has only substance units: false
is: HMDB06519
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473

metaR LEUKTRD4t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
reversible: true
kinetic law: MODEL1310110030#
name: leukotriene D4 transport
is: SBO:0000185

metaR AG13T15g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaR r0714
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110030#

metaR PIt8
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000006
reversible: true
fast: false
name: phosphate transport in/out via Na+ symporter
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM

metaR ACNMLr
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110030#
reversible: true
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
name: N-Acetylneuraminate lyase (reversible)
type: Reaction
kinetic law: MODEL1310110030#

metaM CE2417 m
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:28387
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
is: HMDB11123
initial amount: NaN

metaM pe hs c
initial amount: NaN
has only substance units: false
is: CHEBI:16038
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
is: SBO:0000247
name: phosphatidylethanolamine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_6b15d7b8_215b_4f5f_b1df_919013a9139c
name: ND5
initial amount: NaN
type: Species
initial concentration: NaN
is: P03915
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4540

metaR r1649
type: Reaction
reversible: true
fast: false
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_eff4bdb6_8243_49ba_bbe9_3f750f073d35
initial concentration: NaN
is encoded by: hsa:6716
is: SBO:0000252
is: P31213
has only substance units: false
boundary condition: true
type: Species
constant: false
name: SRD5A2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_657b97c4_01f6_4832_9cca_788252363ddc
has only substance units: false
name: QDPR
is: P09417
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5860
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_00e4f928_3e72_4a3a_bc26_cac11b8380c0
constant: false
has only substance units: false
is: O43678
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4695
name: NDUFA2
initial concentration: NaN

metaR GLCSGLT1le
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_0d5cb329_ae8c_419e_bf08_764bafcae03d
initial concentration: NaN
name: COX6A1
is: P12074
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1337
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_16ffbe4a_582e_4720_95b1_d28171258dc3
type: Species
constant: false
is encoded by: hsa:4830
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NME1
initial concentration: NaN

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
product: MODEL1310110030#
name: carnitine transferase

metaR HPDCACRNCPT1
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
name: carnitine fatty-acyl transferase
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
type: Reaction
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9fd1c901_f130_4f86_be28_9f8947aa4166
is: B2RD24
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:25902
initial concentration: NaN
boundary condition: true
name: MTHFD1L

metaM dmnoncoa c
initial amount: NaN
is: HMDB11604
constant: false
boundary condition: false
type: Species
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false
initial concentration: 1.0
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247

metaR RE1520M
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110030#
name: RE1520
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000

metaR r2099
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#

metaR PGDI
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
name: Prostaglandin-H2 D-isomerase [Precursor]
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.2
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: true

metaM ethamp r
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
type: Species
has only substance units: false
is: SBO:0000247
name: O-phosphonatoethanaminium(1-)
boundary condition: false
is: HMDB00224
initial concentration: 1.0
initial amount: NaN
constant: false

metaR PTPAT
fast: false
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR HPDCACRNCPT2
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
name: heptadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
type: Reaction
product: MODEL1310110030#
reversible: false

metaR r2098
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b26008e6_bb52_48e3_b2e5_d65fab42cfbd
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q76EJ3
is encoded by: hsa:11046
name: SLC35D2
constant: false
initial amount: NaN

metaM hmgcoa c
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
is: HMDB01375
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:15467
type: Species
initial amount: NaN

metaM akg x
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: 2-oxoglutarate(2-)
constant: false
is: HMDB00208

http://identifiers.org/biomodels.db/MODEL1310110030#_eb318f98_1ca6_40e1_857f_f75bc25ce8af
is encoded by: hsa:883
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q16773
initial concentration: NaN
is: SBO:0000252
name: CCBL1
boundary condition: true

metaM 2obut m
initial concentration: 1.0
is: HMDB00005
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16763
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-oxobutanoate
has only substance units: false

metaM CE1940 e
is: CHEBI:52324
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
boundary condition: false
has only substance units: false
name: spermidine monoaldehyde 2
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaM na1 r
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
is: CHEBI:29101
has only substance units: false
constant: false

metaR C226COAtx
product: MODEL1310110030#
is: SBO:0000185
name: fatty acid intracellular transport
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM triodthy c
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
type: Species
has only substance units: false
is: HMDB00265

http://identifiers.org/biomodels.db/MODEL1310110030#_b38d3c54_9425_46d8_8bf8_70e91edf5a88
boundary condition: true
constant: false
is: Q59EH3
type: Species
name: ACP1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:52

metaM mmcoa S m
name: (S)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: CHEBI:57327
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB02310

http://identifiers.org/biomodels.db/MODEL1310110030#_49e58dcc_4dae_4838_8e51_c213a55b3d7f
is encoded by: hsa:100287639
constant: false
initial concentration: NaN
has only substance units: false
name: _100287639_1_c
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_df69d6d2_dd0a_4891_b825_3e7c6038dab0
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: ALG3
is: SBO:0000252
is encoded by: hsa:10195

metaR CYSTHRNaEx
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
reversible: false
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110030#

metaR ASCBOX
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
name: ascorbic acid oxidase
reversible: false
fast: false
kinetic law: MODEL1310110030#

metaM dcdp c
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
is: CHEBI:58593
has only substance units: false
initial concentration: 1.0
type: Species
is: C00705
name: dCDP
initial amount: NaN
boundary condition: false

metaM sphs1p r
has only substance units: false
constant: false
is: CHEBI:60119
initial amount: NaN
type: Species
is: HMDB00277
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124

metaM nh4 n
boundary condition: false
is: CHEBI:28938
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: HMDB00051
name: ammonium
constant: false
initial amount: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR r0717
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110030#
reversible: false
product: MODEL1310110030#

metaR CAATPS
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.6.3.8
name: Ca ATPase
is described by: ECO:0000269
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110030#
reversible: false

metaM na1 c
is: CHEBI:4541
type: Species
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: C01330
has only substance units: false
name: Sodium
boundary condition: false
is: HMDB00588
is: SBO:0000247
initial amount: NaN
constant: false

metaR r0829
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
reversible: true
modifier: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_616fba22_9a15_4d6a_a11c_b979ba5fd19c
name: FASN
type: Species
is: P49327
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2194
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_25e8133f_7158_40d9_baa1_970ecc98207e
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51292
initial amount: NaN
name: GMPR2

metaM ksii core2 pre3 g
is: HMDB00175
boundary condition: false
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 3
initial concentration: 1.0
is: C00130
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
constant: false

metaM nh4 m
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
is: C01342
name: Ammonium
has only substance units: false
is: HMDB00051
type: Species

metaM prostgi2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57403
name: prostaglandin I2(1-)
initial concentration: 1.0
is: HMDB01335

metaM acgam6p c
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01062
initial concentration: 1.0
name: N-acetyl-D-glucosamine 6-phosphate(2-)
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57513

metaM dtmp c
initial amount: NaN
boundary condition: false
name: dTMP
is: HMDB01227
type: Species
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
initial concentration: 1.0
is: C00364
constant: false
is: SBO:0000247

metaR ACETONEt2
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
name: acetone transport via proton symport
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
is described by: ECO:0000269
type: Reaction

metaM ksi pre16 g
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 16
initial amount: NaN
is: C00130
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110030#_5edc3a2c_5dd4_4e91_895f_ac7aac50b854
initial amount: NaN
boundary condition: true
name: ACAA2
type: Species
is: P42765
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10449
constant: false

metaR r1007
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_67f417b5_5ccb_476d_a1c1_be081dc89282
is encoded by: hsa:427
initial concentration: NaN
initial amount: NaN
name: ASAH1
is: SBO:0000252
is: Q13510
boundary condition: true
has only substance units: false
type: Species
constant: false

metaM 1pyr5c c
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
is: CHEBI:15893
is: C03912
is: SBO:0000247
has only substance units: false
is: HMDB01301
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false
boundary condition: false
initial concentration: 1.0

metaM akg m
has only substance units: false
is: C00026
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16810
is: SBO:0000247
is: HMDB00208
boundary condition: false
name: 2-Oxoglutarate

metaR FACOAL203
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110030#
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_54658b82_f39e_4233_8d92_d732cd677832
is encoded by: hsa:275
is: P48728
has only substance units: false
initial concentration: NaN
name: AMT
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaM 34hpl m
is: CHEBI:36659
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
is: HMDB00755
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: 3-(4-hydroxyphenyl)lactate
type: Species

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
modifier: MODEL1310110030#
reversible: false
type: Reaction
name: riboflavin kinase
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_60233a12_4361_4391_a8f2_67fdeb0f1eb1
initial amount: NaN
is encoded by: hsa:4716
name: NDUFB10
has only substance units: false
initial concentration: NaN
is: A8K761
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaM 2hb c
type: Species
is: CHEBI:1148
is: HMDB00008
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: 2-Hydroxybutyrate
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

metaM pe hs m
is: SBO:0000247
is: CHEBI:16038
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR r0129
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
reversible: true
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_a30f813b_4fa2_42b4_88d3_990b15341b4c
initial concentration: NaN
boundary condition: true
name: PAFAH1B3
type: Species
has only substance units: false
is encoded by: hsa:5050
is: Q15102
is: SBO:0000252
constant: false
initial amount: NaN

metaM na1 e
is: HMDB00588
is: CHEBI:4541
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
type: Species
name: Sodium
initial amount: NaN
is: C01330

metaM sphs1p e
type: Species
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
has only substance units: false
is: HMDB00277

metaR RE1898C
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1898
fast: false
reversible: true
product: MODEL1310110030#
type: Reaction

metaR RE2999M
fast: false
is: SBO:0000176
name: RE2999
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#

metaM ha l
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16336
initial concentration: 1.0
name: hyaluronan

http://identifiers.org/biomodels.db/MODEL1310110030#_0b02e987_10a2_4a59_86a5_8067bdfb818e
has only substance units: false
name: BTD
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:686
initial amount: NaN
type: Species
initial concentration: NaN
is: P43251

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
fast: false
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reactant: MODEL1310110030#
is described by: ECO:0000269
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: fatty-acid--CoA ligase
type: Reaction
product: MODEL1310110030#
is: SBO:0000176

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
boundary condition: false
type: Species
has only substance units: false
name: dTMP(2-)
is: CHEBI:26999
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7899c690_967d_4885_8cf8_ad392b06d486
constant: false
is: E9PAK4
has only substance units: false
is encoded by: hsa:200010
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC5A9
initial amount: NaN

metaR PRO Dtde
is described by: ECO:0000134
is: SBO:0000185
name: D-proline transport, extracellular
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_15295532_3347_4027_b60b_1384a1c782e9
is encoded by: hsa:1609
has only substance units: false
is: P52824
type: Species
boundary condition: true
name: DGKQ
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1008
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_ce0a8447_1f67_434a_84bf_c4ecc7ebd1d0
is: SBO:0000252
initial amount: NaN
is: Q5MY95
initial concentration: NaN
name: ENTPD8
has only substance units: false
is encoded by: hsa:377841
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_80329c94_e891_437a_9cb0_dfdcaca60c32
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA021081
boundary condition: true
type: Species
name: _AA021081_1_r
initial amount: NaN

metaM g1m8mpdol L r
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
is: C05870
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f5b48435_4406_4711_aa4f_ac01d5d0ca25
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _H17063_1_m
constant: false
boundary condition: true
is encoded by: hsa:H17063

http://identifiers.org/biomodels.db/MODEL1310110030#_de317df6_0ec0_4dd4_9c7f_7508e32e8436
boundary condition: true
is: P00915
is encoded by: hsa:759
name: CA1
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM CE2251 c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C41H68N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H72N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h27-28,30,34-36,40,52-53H,4-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: CE2251
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:52327
name: 3-oxoeicosanoyl-CoA
constant: false

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR O2tm
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
fast: false
type: Reaction
reversible: true
name: O2 transport (diffusion)

metaM hpdca e
is: HMDB02259
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:32366
name: margarate
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial concentration: 1.0

metaM 2hb e
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: HMDB00008
is: CHEBI:1148
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
is: CHEBI:30623
is: HMDB02329
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

metaR NADPtru
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
name: NADP transporter, endoplasmic reticulum
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaR HISD
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
type: Reaction
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
name: histidase
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/4.3.1.3
is: SBO:0000176
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_fb3fd7f4_0b4a_42f4_b9bc_7531e06bce65
type: Species
boundary condition: true
is encoded by: hsa:2629
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B7Z6S1
name: GBA
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1e48ca43_f203_4d78_9bc3_31f9480c0f72
name: _D29675_1_c
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:D29675
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_3a1f9917_b5ca_445b_aa2a_52c35d5c0990
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56894
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: AGPAT3

metaR DGNSKm
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
name: deoxyguanosine kinase
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
reversible: false

metaR 5ADTSTSTERONEtr
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
name: 5 alpha dihydrotesterone intracellular transport

metaM hyptaur c
boundary condition: false
name: Hypotaurine
is: HMDB00965
initial concentration: 1.0
has only substance units: false
is: CHEBI:16668
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0f99eaea_5497_448a_8c5f_edc10a1b723b
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_0427377e_6225_47a9_bacf_6d025ab5b465
initial amount: NaN
name: CDA
type: Species
is encoded by: hsa:978
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P32320
constant: false
has only substance units: false

metaM hmgcoa m
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:15467
boundary condition: false
type: Species
is: SBO:0000247

metaM his L c
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
is: HMDB00177
type: Species
has only substance units: false
name: L-histidine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_6dee37b5_b518_4533_935b_7c564365fe66
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ALDOA
is encoded by: hsa:226
is: SBO:0000252
is: P04075
initial concentration: NaN
initial amount: NaN

metaM chlstol r
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06842
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: CHEBI:16290
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

metaR r0410
is: SBO:0000176
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110030#

metaM hpdca c
name: margarate
has only substance units: false
constant: false
is: CHEBI:32366
is: HMDB02259
type: Species
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM ptrc e
initial concentration: 1.0
name: Putrescine
constant: false
is: CHEBI:326268
boundary condition: false
is: HMDB01414
initial amount: NaN
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_57ace354_878f_43d8_8c73_da5c8561950d
initial amount: NaN
name: CYP8B1
has only substance units: false
initial concentration: NaN
is: Q9UNU6
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1582

http://identifiers.org/biomodels.db/MODEL1310110030#_06a88d51_4b59_4b13_a1ac_84cb1eaf4bd2
is encoded by: hsa:AF080579
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: _AF080579_1_c
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_385d4408_9928_488b_9ed0_8ec7de8f9435
is: Q15758
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC1A5
has only substance units: false
is encoded by: hsa:6510
initial concentration: NaN

metaR CYTK9n
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP),nuclear
kinetic law: MODEL1310110030#
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_e82abb69_271c_4567_8a7e_f243de9c66cf
initial concentration: NaN
is: SBO:0000252
name: PIGP
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51227

metaR O2tp
reactant: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
name: O2 transport, peroxisomal
is described by: ECO:0000000

metaM his L e
constant: false
name: L-histidine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_17e1152b_4ab1_4093_b0da_23a5e7a762bc
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q71UM8
name: ADCY2
has only substance units: false
is encoded by: hsa:108

metaR GAPD
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.12
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
name: glyceraldehyde-3-phosphate dehydrogenase

metaM l2fn2m2masn g
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine

metaM nh4 e
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
constant: false
is: CHEBI:28938
has only substance units: false
name: ammonium
initial amount: NaN
is: HMDB00051
initial concentration: 1.0
type: Species

metaR OCD11CRNCPT2
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM glutcoa m
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial concentration: 1.0
name: glutaryl-CoA(5-)
is: CHEBI:57378
is: HMDB01339
constant: false
initial amount: NaN

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM nh4 c
is: CHEBI:28938
is: SBO:0000247
type: Species
is: HMDB00051
initial amount: NaN
constant: false
is: C01342
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
has only substance units: false

metaR GLPASE2
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5834.1) or (5836.1) or (5837.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES:NCD
is: SBO:0000176
reversible: false
name: glycogen phosphorylase (amyls -> glc-D)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.1
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ef19801a_c34b_4a12_bc5f_08371051f810
is: SBO:0000252
name: NDUFA4
type: Species
initial amount: NaN
is: O00483
constant: false
boundary condition: true
is encoded by: hsa:4697
has only substance units: false
initial concentration: NaN

metaR r0287
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
fast: false
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176

metaM HC01104 e
constant: false
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
boundary condition: false
is: CHEBI:61146
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_e7ec3c42_eb40_4eb9_8bf0_9b2871c72ced
is encoded by: hsa:6531
initial concentration: NaN
name: SLC6A3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q01959
has only substance units: false

metaM dmnoncoa x
type: Species
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
is: HMDB11604
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false

metaR TSTSTERONEt
is described by: ECO:0000269
reversible: true
fast: false
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185

metaR r0560
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110030#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM tststerone c
is: CHEBI:17347
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
type: Species
name: testosterone
is: HMDB00234
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR LYStip
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
type: Reaction
kinetic law: MODEL1310110030#
reversible: false
name: L-lysine transport, peroxisomal (irreversible)
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_1e00f33d_3497_43aa_bea2_efd545ba3907
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: ALDH3A1
is: P30838
initial concentration: NaN
is encoded by: hsa:218
is: SBO:0000252

metaR GLPASE1
reactant: MODEL1310110030#
reversible: false
is: SBO:0000176
name: glycogen phosphorylase (glygn2 -> dxtrn)
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5834.1) or (5837.1) or (5836.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.1 Confidence Level: 4 AUTHORS: PMID:3346228 NOTES:NCD
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.1
kinetic law: MODEL1310110030#
fast: false

metaR r1010
fast: false
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR LALDO
is: SBO:0000176
reversible: true
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reactant: MODEL1310110030#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_bcb261e2_8bd4_4eb6_b1af_8bfac8e491b0
name: ATP5A1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:498
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B4DY56

metaM dtmp m
initial concentration: 1.0
boundary condition: false
is: HMDB01227
name: dTMP
is: SBO:0000247
is: C00364
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
is: CHEBI:26999
has only substance units: false
initial amount: NaN

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM HC01162 c
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58376
has only substance units: false
is: SBO:0000247

metaR GBAl
type: Reaction
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
product: MODEL1310110030#
reversible: false
name: Glucosylceramidase
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.45

metaR LPS3
is described by: ECO:0000000
modifier: MODEL1310110030#
product: MODEL1310110030#
name: lipase
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
reversible: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.23

http://identifiers.org/biomodels.db/MODEL1310110030#_43958557_a0ad_40b7_8599_50b30eb6603e
boundary condition: true
is encoded by: hsa:158
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: ADSL
initial concentration: NaN
type: Species

metaR G14T2g
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110030#_0f5e6a88_2796_4db8_8d63_56685416a796
is: P09923
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: ALPI
constant: false
is encoded by: hsa:248

http://identifiers.org/biomodels.db/MODEL1310110030#_7c0639e1_2ba5_4e18_ab2f_0b71be2ce01c
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: ABCA1
is encoded by: hsa:19
is: O95477
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7d9f286c_3643_440d_b209_c18a68ba41f5
constant: false
name: TK1
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P04183
is encoded by: hsa:7083
has only substance units: false

metaM nrpphr c
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:33569
is: HMDB00216
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_80f42670_4f26_4041_8192_e4d7cb9b7cb5
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:H77542
type: Species
initial amount: NaN
name: _H77542_1_r

metaR KSII CORE4t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110030#
reversible: false
fast: false
name: keratan sulfate II (core4) transport, golgi to extracellular
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#

metaR SERPT
is described by: ECO:0000269
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110030#
name: serine C-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.50
modifier: MODEL1310110030#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_acef0241_d264_4cfe_8da2_c55490a9d108
initial amount: NaN
initial concentration: NaN
name: _AI378339_1_m
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI378339

metaM pe hs r
name: phosphatidylethanolamine
is: SBO:0000247
constant: false
is: CHEBI:16038
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_81d47baf_ebed_4348_81b6_bcf22d6eb966
initial concentration: NaN
name: SLC25A10
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1468
is: Q9UBX3
initial amount: NaN

metaM his L m
name: L-histidine
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:15971
is: HMDB00177
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_e5b2f223_1e79_4612_9cde_58b05897c690
constant: false
is: G3XA95
type: Species
is encoded by: hsa:8611
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PPAP2A

http://identifiers.org/biomodels.db/MODEL1310110030#_b0af4107_d261_4ac7_9a6a_db9e9a7bfdfa
constant: false
has only substance units: false
name: _AD000092_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AD000092
initial amount: NaN
type: Species
initial concentration: NaN

metaR FAOXC13C11m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_07f5c012_da6b_4520_8ecb_25813e2dfa32
name: SLC26A7
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:115111
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM core6 l
boundary condition: false
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: Core 6

http://identifiers.org/biomodels.db/MODEL1310110030#_de59b7f9_6972_4a29_928c_a1e5ea0d94cf
initial concentration: NaN
is encoded by: hsa:5331
is: SBO:0000252
is: G5E960
constant: false
name: PLCB3
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_03a4e3c5_12f5_4735_afdb_5a76eb78b1ec
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9BZV2
boundary condition: true
constant: false
initial concentration: NaN
name: SLC19A3
is encoded by: hsa:80704

http://identifiers.org/biomodels.db/MODEL1310110030#_8f9c9ae0_a087_4371_99e3_1ab97d8d07d2
has part: Q13956
has part: P16499
is encoded by: hsa:5149
name: PDE6A:PDE6H:PDE6B
is encoded by: hsa:5158
initial amount: NaN
is encoded by: hsa:5145
type: Species
has only substance units: false
has part: B7Z9T9
constant: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_9e2d8d92_cd6f_4e6e_a16c_fe62aa606a2f
initial concentration: NaN
is: Q86WA9
constant: false
is encoded by: hsa:284129
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: SLC26A11

metaM prostgi2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
constant: false
is: HMDB01335
has only substance units: false
name: prostaglandin I2(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57403

metaR VD3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
name: Vitamin D3 formation
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110030#

metaM ksi deg22 l
is: CHEBI:16953
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 22
has only substance units: false
is: HMDB00812
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9420d6b8_fd52_44c9_bc05_0da12bf46aab
constant: false
name: PIGH
boundary condition: true
is encoded by: hsa:5283
type: Species
is: Q14442
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.35
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110030#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR NACASPAH
modifier: MODEL1310110030#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.1.15
product: MODEL1310110030#
name: N-Acetyl-L-aspartate amidohydrolase
kinetic law: MODEL1310110030#

metaM nrpphr e
type: Species
is: HMDB00216
constant: false
is: CHEBI:33569
is: SBO:0000247
boundary condition: false
name: Norepinephrine
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_a21eb5ee_f8a9_41d4_82b0_654de9797361
type: Species
name: _100128062_1_m
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:100128062

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
is: CHEBI:58190
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: ethamp[c]
is: HMDB00224

metaR BDHm
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110030#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
boundary condition: false
constant: false
is: HMDB01301
is: CHEBI:15893
is: C03912
initial amount: NaN

metaR r0818
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is: SBO:0000185
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Transport reaction
type: Reaction
kinetic law: MODEL1310110030#

metaM g3p c
is: C00661
initial amount: NaN
constant: false
is: HMDB01112
boundary condition: false
initial concentration: 1.0
is: CHEBI:58027
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: http://identifiers.org/pubchem.compound/3930
type: Species
is: SBO:0000247
name: Glyceraldehyde 3-phosphate

metaR GCALDD
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
name: Glycolaldehyde dehydrogenase
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_4ef74509_75ce_43bb_93ac_89192fe1241a
is encoded by: hsa:10229
is: Q99807
initial amount: NaN
boundary condition: true
name: COQ7
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaM 5aizc c
is: CHEBI:58564
boundary condition: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
has only substance units: false
is: C04751
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: HMDB06273
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM mpdol L c
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
is: CHEBI:18396
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
boundary condition: false
constant: false

metaR r1947
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

metaR NACHEX13ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110030#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_1589db44_e30d_4470_9b14_80b4975437f4
initial concentration: NaN
is: Q8NCL4
constant: false
has only substance units: false
is encoded by: hsa:11226
initial amount: NaN
name: GALNT6
boundary condition: true
is: SBO:0000252
type: Species

metaR r0281
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
reversible: true
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_c2722669_0d80_4784_8cd3_02c5c37f60c6
type: Species
is encoded by: hsa:AI480132
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AI480132_1_c
initial concentration: NaN
has only substance units: false

metaM tststerone e
type: Species
constant: false
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
is: HMDB00234
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17347

metaR 5ADTSTSTERONESte
reversible: true
type: Reaction
product: MODEL1310110030#
fast: false
name: sulfonated testosterone transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR r2094
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_2775ef3f_0917_4363_b128_79af57ab93f0
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4718
name: NDUFC2
type: Species
is: Q549M5
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_acb08442_e605_4f18_88a5_751644a61588
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P47989
is encoded by: hsa:7498
boundary condition: true
initial amount: NaN
constant: false
name: XDH

metaR r1643
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_c6b388b2_6c88_4420_8b1e_2616c6029d4f
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: ACLY
type: Species
initial amount: NaN
is: P53396
is: SBO:0000252
is encoded by: hsa:47

metaM acrn x
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
is: CHEBI:57589
is: SBO:0000247
boundary condition: false
has only substance units: false
name: O-acetylcarnitine
type: Species
initial concentration: 1.0
constant: false

metaM prostgi2 c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57403
name: prostaglandin I2(1-)
is: HMDB01335

metaR AG13T1g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#

metaR GALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110030#
name: galactose efflux from lysosome
fast: false
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ef562274_8587_4a95_adbc_8d4a64ee6653
name: SLC26A1
initial concentration: NaN
is encoded by: hsa:10861
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d203ec20_2f36_484a_bd38_035515d594b3
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:51004
is: B7Z3K8
name: COQ6
constant: false

metaR SRTNtu
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000269
reversible: true
name: Serotonin uniport
kinetic law: MODEL1310110030#

metaR r2095
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_b98b1ccd_9619_43a3_bd90_69264f1cc14b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:221823
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: PRPS1L1

http://identifiers.org/biomodels.db/MODEL1310110030#_3f228ca3_f3fa_4a46_8c2f_82230eb47980
initial amount: NaN
is: P49189
is encoded by: hsa:223
type: Species
name: ALDH9A1
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM itacon m
is: CHEBI:17240
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02092
type: Species
is: SBO:0000247
constant: false

metaR PGSr
fast: false
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
kinetic law: MODEL1310110030#
name: Prostaglandin G/H synthase
is described by: ECO:0000269
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.99.1

http://identifiers.org/biomodels.db/MODEL1310110030#_30905568_5307_4f5c_adf2_a6c53d55abe0
is: B4DZR2
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8854
name: ALDH1A2

metaR r1642
is: SBO:0000185
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
type: Reaction

metaR PDE4
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
name: 3',5'-cyclic-nucleotide phosphodiesterase
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9eccbbc3_2bb0_4682_9c22_8158f67d62b8
is encoded by: hsa:2592
initial amount: NaN
name: GALT
type: Species
is: B2RAT6
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a900fbc7_ebbf_4cd3_88ea_fe1ab2996e49
is: O60658
name: PDE8A
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110030#_47f70c54_f127_4978_a476_dae02fb92d44
is: SBO:0000252
constant: false
name: PAFAH1B2
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5049
initial concentration: NaN
is: A8DPS7
initial amount: NaN

metaR r2096
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
type: Reaction

metaM mal L m
initial amount: NaN
is: SBO:0000247
name: (S)-malate(2-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
type: Species
has only substance units: false
constant: false
is: HMDB00156

metaR GGH 6DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110030#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_5552b86e_07b7_4a5f_be34_8e4c258f7021
is encoded by: hsa:4536
constant: false
boundary condition: true
name: ND2
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q7GXY9

metaM CE5118 m
is: HMDB00127
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: CHEBI:15748
type: Species
is: SBO:0000247

metaM nm2masn g
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C05884
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C42H70N3O30X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1641
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#

metaR S6T16g
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110030#_68d88992_bd11_452c_b39e_696e941417e0
is: Q674R7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: ATG9B
is encoded by: hsa:285973
initial amount: NaN

metaR ABTti
kinetic law: MODEL1310110030#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

metaR r2097
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185

metaM ksi pre24 g
is: CHEBI:58053
is: HMDB00175
type: Species
is: C00130
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 24
constant: false
notes: FORMULA: C191H306N13O158S7X CHARGE: -8

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_76b2a64c_52bf_467e_9bdd_2a38a4cb5d11
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O95498
boundary condition: true
name: VNN2
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8875

http://identifiers.org/biomodels.db/MODEL1310110030#_263c2c39_86a7_4b78_bcd3_57b08c23b053
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: FTCD
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10841

metaR r1640
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#

metaM uacgam c
is: HMDB00290
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57705
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

metaM ksi pre3 g
boundary condition: false
initial amount: NaN
notes: FORMULA: C93H152N6O67X CHARGE: -1
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
type: Species
is: C00130
initial concentration: 1.0
constant: false
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_db033d98_1493_4b7d_9f35_621daa08c640
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:376497
has only substance units: false
initial amount: NaN
name: SLC27A1
constant: false
is: SBO:0000252

metaR S6T18g
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110030#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaM nac c
initial concentration: 1.0
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01488
name: Nicotinate
is: CHEBI:0
initial amount: NaN

metaR FRUt4
fast: false
reversible: true
name: D-fructose transport via sodium cotransport
is: SBO:0000185
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction

metaR r2090
modifier: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185

metaR FAOXC10C8x
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_10c5d95f_cda2_4490_88e5_5b26d08c6895
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:6470
name: SHMT1

metaM acald x
name: acetaldehyde
is: CHEBI:15343
is: HMDB00990
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
has only substance units: false

metaR r1647
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8d59cf18_eca5_458d_aab8_1796a4678a2c
name: DECR1
is: SBO:0000252
is encoded by: hsa:1666
is: Q16698
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_cc46ecb2_827c_4369_82e4_ee052a5327c6
is: SBO:0000252
initial concentration: NaN
is: Q9UBY0
name: SLC9A2
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6549

metaR r1116
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

metaR ARACHDCOAtx
name: fatty acid intracellular transport
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reversible: true
product: MODEL1310110030#

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR MCLOR
name: 3-Mercaptolactate:NAD+ oxidoreductase
reversible: true
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#

metaR r2091
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110030#
is: SBO:0000185
reversible: true
product: MODEL1310110030#

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
type: Reaction
modifier: MODEL1310110030#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR ACNAMtn
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: N-acetylneuraminate nuclear import
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction

metaR C14STRr
reactant: MODEL1310110030#
name: C-14 sterol reductase
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110030#
is described by: ECO:0000134
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction

metaR r1646
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#

metaR r2092
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR DECDPtm
fast: false
product: MODEL1310110030#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110030#

metaM amp x
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: SBO:0000247
name: AMP
is: C00020
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:456215
type: Species

metaM nac e
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
boundary condition: false
type: Species
is: HMDB01488
has only substance units: false
initial amount: NaN
is: CHEBI:0
name: Nicotinate

http://identifiers.org/biomodels.db/MODEL1310110030#_e8a1d56b_0b9e_4cc3_806c_e80476a97fa9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: AKR1A1
is: P14550
has only substance units: false
type: Species
is encoded by: hsa:10327
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7b80c5b0_b2ef_458c_a0f1_272b6548d7a7
has only substance units: false
is: Q9P212
boundary condition: true
initial amount: NaN
constant: false
name: PLCE1
initial concentration: NaN
is encoded by: hsa:51196
type: Species
is: SBO:0000252

metaM ksi pre6 g
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00130
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 6
constant: false
initial concentration: 1.0
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: HMDB00175
is: CHEBI:58053

metaR r1645
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM dem2emgacpail prot hs r
has only substance units: false
is: SBO:0000247
constant: false
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
initial amount: NaN
is: CHEBI:53486
boundary condition: false
initial concentration: 1.0
is: HMDB02925
type: Species

metaM core6 g
boundary condition: false
constant: false
is: CHEBI:16478
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Core 6

metaR DNDPt5m
reversible: false
modifier: MODEL1310110030#
name: dATP transport via dTDP antiport
is described by: ECO:0000269
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
reactant: MODEL1310110030#

metaM mi1p D c
is: HMDB02985
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58433
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
has only substance units: false
name: 1D-myo-inositol 1-phosphate(2-)
constant: false

metaM HC01415 m
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:27537
boundary condition: false
name: (2E)-Octenoyl-CoA
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaR AG13T3g
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110030#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5a5dad5a_2449_4af2_a924_5ecc339ee476
constant: false
is: Q6LEN6
is: SBO:0000252
type: Species
is encoded by: hsa:1103
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110030#_62b2d776_465d_49eb_92d7_dd9cbce9f839
initial concentration: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:8908
has part: P54840
is encoded by: hsa:2998
has part: O15488
type: Species
name: GYS2:GYG2
constant: false
boundary condition: true
initial amount: NaN

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110030#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaR S6T9g
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
type: Reaction
is described by: ECO:0000000

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
fast: false
is described by: ECO:0000134
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110030#

metaR r1644
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM uacgam g
boundary condition: false
initial amount: NaN
is: HMDB00290
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57705
is: SBO:0000247
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

http://identifiers.org/biomodels.db/MODEL1310110030#_17c9b862_de46_4188_b0d3_91b741457ca7
is: Q9Y303
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51005
is: SBO:0000252
initial amount: NaN
name: AMDHD2

metaM HC01376 m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
type: Species
has only substance units: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
boundary condition: false
is: CHEBI:28692
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_44c96649_df95_4faa_91e3_0342688898a3
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: Q9Y673
name: ALG5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29880

http://identifiers.org/biomodels.db/MODEL1310110030#_af560250_ea2c_4153_8b09_bba61674032e
initial amount: NaN
type: Species
name: TUSC3
constant: false
is: Q13454
boundary condition: true
is encoded by: hsa:7991
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM sarcs c
name: Sarcosine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0
is: HMDB00271
is: C00213
constant: false
is: CHEBI:3513
boundary condition: false
has only substance units: false

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110030#

metaM ksi deg30 l
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 30
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C90H147N6O75S3 CHARGE: -3

metaM CE2247 c
initial concentration: 1.0
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h27-30,34-36,40,49,52-53H,4-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/t29?,30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: CE2247
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 3-hydroxyeicosanoyl-CoA
has only substance units: false
type: Species
constant: false
is: CHEBI:52324

metaR S6T7g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110030#
modifier: MODEL1310110030#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
fast: false

metaM e4p c
type: Species
is: SBO:0000247
is: HMDB01321
boundary condition: false
is: C00279
constant: false
initial amount: NaN
is: CHEBI:16897
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
name: D-Erythrose 4-phosphate

metaR r0726
modifier: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9021eed9_0680_422b_9aed_04107f0590c6
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q9BV79
is encoded by: hsa:51102
boundary condition: true
name: MECR

http://identifiers.org/biomodels.db/MODEL1310110030#_beef4972_a79d_4643_b48f_735f0e826b7f
type: Species
boundary condition: true
is: P49189
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:223
name: ALDH9A1
has only substance units: false
is: SBO:0000252

metaM dad 2 e
type: Species
is: HMDB00101
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: CHEBI:17256
name: 2-deoxyadenosine
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_107912cf_9795_414e_8a9c_40eadc1544ac
type: Species
is encoded by: hsa:5281
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: PIGF
is: Q6IB04
is: SBO:0000252

metaM eicostet e
constant: false
type: Species
is: HMDB02177
is: SBO:0000247
name: eicosatetranoic acid
is: CHEBI:36033
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
initial concentration: 1.0
boundary condition: false

metaM acald e
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
name: acetaldehyde
boundary condition: false
has only substance units: false
is: CHEBI:15343
is: HMDB00990
initial amount: NaN

metaM acrn r
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
boundary condition: false
is: HMDB00201
initial amount: NaN
is: CHEBI:57589
constant: false
name: O-acetylcarnitine

metaR r0830
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
modifier: MODEL1310110030#
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_49d7b238_6c62_4f43_a59c_dd95b609a495
is encoded by: hsa:5145
initial amount: NaN
boundary condition: true
name: PDE6A
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: P16499
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_32914dde_8efa_4f9a_8005_e7c66a1bfcbf
initial amount: NaN
constant: false
name: CDO1
is: Q16878
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1036

http://identifiers.org/biomodels.db/MODEL1310110030#_f83cc42e_4ff5_4a46_a5ad_7892841b3862
has only substance units: false
is: P61457
boundary condition: true
initial amount: NaN
is encoded by: hsa:5092
constant: false
initial concentration: NaN
name: PCBD1
type: Species
is: SBO:0000252

metaR ALDD2x
name: aldehyde dehydrogenase (acetaldehyde, NAD)
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is described by: ECO:0000000
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM gthrd e
is: HMDB00125
boundary condition: false
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: glutathionate(1-)
type: Species
constant: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM mal L e
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: (S)-malate(2-)
initial amount: NaN
is: HMDB00156
initial concentration: 1.0
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9f96893e_ce9e_4fae_95e1_4afac7b057da
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:53354
type: Species
name: PANK1
is: SBO:0000252

metaR AG13T14g
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
modifier: MODEL1310110030#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110030#

metaR ILEt5m
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Isoleucine mitochondrial transport
is described by: ECO:0000000
fast: false
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR C141ACBP
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaM ksii core2 deg5 l
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: HMDB00143
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaM acald c
initial concentration: 1.0
is: HMDB00990
initial amount: NaN
name: acetaldehyde
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:15343

http://identifiers.org/biomodels.db/MODEL1310110030#_caeac1ff_cd3e_4421_8823_f9c848531382
name: ALDH1A2
is encoded by: hsa:8854
constant: false
is: SBO:0000252
is: F5H2Y9
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaM cysam c
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: HMDB02991
type: Species
initial amount: NaN
name: cysteaminium
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58029
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_0779f541_cfc2_49c5_b9ea_8044af6fbe37
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: B4DX62
constant: false
boundary condition: true
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487

metaM dlnlcg e
is: HMDB02925
constant: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN
initial concentration: 1.0
name: dihomo-gamma-linolenic acid (n-6)
boundary condition: false
has only substance units: false
is: CHEBI:53486
type: Species
is: SBO:0000247

metaM dad 2 c
name: 2-deoxyadenosine
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00101
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
constant: false
is: CHEBI:17256
initial amount: NaN

metaR FAOXC5C3x
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_afb529cb_91a2_4036_84a0_8e97c2d6d230
name: PHPT1
initial amount: NaN
is encoded by: hsa:29085
constant: false
is: Q9P019
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaM gthrd c
name: Reduced glutathione
is: C00051
is: SBO:0000247
is: HMDB00125
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_4fd6c7b3_c630_4690_aca1_289005a366d3
initial amount: NaN
has only substance units: false
name: SLC28A3
is encoded by: hsa:64078
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q9HAS3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_e926d887_4178_4cf3_895a_65915c5b2525
name: ST3GAL1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6482
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_3a17bbed_ac88_4dd7_8be8_e04df9238599
boundary condition: true
has only substance units: false
name: NAE1
initial concentration: NaN
is encoded by: hsa:8883
constant: false
is: A8MU28
type: Species
is: SBO:0000252
initial amount: NaN

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaM leuktrC4 c
is: SBO:0000247
has only substance units: false
name: leukotriene C4(2-)
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
is: HMDB01198
is: CHEBI:57973
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

metaR FAOXC14C12m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
is: CHEBI:18021
is: HMDB00263
initial amount: NaN
name: Phosphoenolpyruvate
boundary condition: false
is: C00074
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaM dlnlcg c
is: HMDB02925
constant: false
has only substance units: false
initial concentration: 1.0
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
boundary condition: false
is: CHEBI:53486

metaM amp r
is: CHEBI:456215
boundary condition: false
initial amount: NaN
name: AMP
is: SBO:0000247
is: HMDB00045
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaM meoh l
name: methanol
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
is: CHEBI:17790

metaR GHMT2rm
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: true
name: glycine hydroxymethyltransferase, reversible, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_c894b65b_e47a_4049_8744_6529c5b5e191
type: Species
is encoded by: hsa:3945
constant: false
initial amount: NaN
is: P07195
has only substance units: false
is: SBO:0000252
name: LDHB
initial concentration: NaN
boundary condition: true

metaM pro D e
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247
constant: false
type: Species
has only substance units: false
name: D-proline
is: HMDB03411
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM hs deg25 l
is: SBO:0000247
is: CHEBI:16126
constant: false
notes: FORMULA: C23H37O21 CHARGE: -1
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5ec5d7b4_aac4_49a9_bfb5_6e9563b8f69c
is: E9PB82
constant: false
is encoded by: hsa:3295
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: HSD17B4
initial amount: NaN
has only substance units: false

metaR SUCCTD
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR CGLYt3 2
modifier: MODEL1310110030#
is described by: ECO:0000304
reversible: false
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Cys-Gly transport in via proton symport
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a3d6b5da_bb37_4eaa_b279_8da2891dd409
is encoded by: hsa:5277
is: SBO:0000252
name: PIGA
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_c224fc26_681e_45f9_ba2f_6a1626f55e4d
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: P22413
has only substance units: false
name: ENPP1
is encoded by: hsa:5167

metaM sarcs e
initial amount: NaN
name: sarcosine
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
constant: false
is: HMDB00271
initial concentration: 1.0
is: CHEBI:15611

http://identifiers.org/biomodels.db/MODEL1310110030#_58708592_4059_4c19_b4e3_d4f2e29200a8
is: SBO:0000252
constant: false
is encoded by: hsa:4712
boundary condition: true
type: Species
is: O95139
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NDUFB6

metaM cholcoar x
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02178
type: Species
constant: false
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN

metaR r0559
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110030#_c03fce8f_1f82_4f54_8a51_40db8d712655
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: O15427
name: SLC16A3
is encoded by: hsa:9123
is: SBO:0000252

metaM eicostet c
constant: false
is: HMDB02177
is: SBO:0000247
name: eicosatetranoic acid
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1

metaR S6T15g
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110030#

metaR CSBPASEly
reversible: false
fast: false
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
is: SBO:0000176
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b109d94d_3b74_4f6f_bd92_b0ce31883e1c
type: Species
is encoded by: hsa:4669
is: P54802
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NAGLU
initial concentration: NaN
constant: false
has only substance units: false

metaR RE1233C
reversible: true
fast: false
modifier: MODEL1310110030#
name: RE1233
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction

metaR CYSGLTH
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
product: MODEL1310110030#
name: Glutathione:cystine oxidoreductase
type: Reaction
is described by: ECO:0000000

metaR 34DHXMANDACOX NADP
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
is: CHEBI:28264
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_bcbb4a14_04ca_4b7c_9562_1c9dc75db0d4
initial amount: NaN
is encoded by: hsa:9060
name: PAPSS2
type: Species
initial concentration: NaN
is: SBO:0000252
is: O95340
constant: false
boundary condition: true
has only substance units: false

metaM arachdcoa m
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57368
name: arachidonoyl-CoA(4-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06523

metaR S6TASE8ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR DESAT22 2p
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false

metaR RE1534M
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1534
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110030#
fast: false

metaM ksi pre15 g
type: Species
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: C00130
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 15

metaR GLCAASE4ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
reversible: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: beta-glucuronidase, lysosomal
type: Reaction
fast: false
modifier: MODEL1310110030#

metaR r0839
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_9d666384_40ad_46a0_a143_ba572555a28e
is encoded by: hsa:55568
name: GALNT10
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_908b8070_3f06_426f_b273_f3b77f44c8c8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: ATP2B2
initial amount: NaN
is encoded by: hsa:491
is: Q4J699

http://identifiers.org/biomodels.db/MODEL1310110030#_adf74150_37c3_45f0_9bf9_099b146c443b
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4700
name: NDUFA6
is: P56556

metaM fol e
name: Folate
is: HMDB00121
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM HC02175 c
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
is: CHEBI:27689
name: caprate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f671a87d_d790_4b17_b17e_b62bdb388e0a
has only substance units: false
boundary condition: true
is: Q15849
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC14A2
is encoded by: hsa:8170
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_ed7b0cdb_6825_43a9_aecf_51523af615f0
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SLC38A5
is: Q8WUX1
type: Species
has only substance units: false
is encoded by: hsa:92745
initial concentration: NaN

metaR r0838
name: Free diffusion
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
type: Reaction
modifier: MODEL1310110030#
reversible: true
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110030#
is described by: ECO:0000000

metaM 2mpdhl m
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_f54f9682_92fb_47a8_a61a_da3898afd1e0
has only substance units: false
is encoded by: hsa:55577
is: SBO:0000252
name: NAGK
is: Q9UJ70
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaR GTHRDt
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
name: Glutathione transport into mitochondria
is: SBO:0000185

metaM gthrd m
has only substance units: false
is: HMDB00125
boundary condition: false
name: glutathionate(1-)
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57925

http://identifiers.org/biomodels.db/MODEL1310110030#_089cf6f1_60cc_4645_870d_a279e077f1e2
name: HPGDS
has only substance units: false
is: O60760
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27306

metaR r0268
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
type: Reaction
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110030#

metaM acald m
name: acetaldehyde
is: HMDB00990
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
is: CHEBI:15343
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_77db84de_8571_4b1c_8ddf_fa17b94a366c
is: Q96CA6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:30
has only substance units: false
initial amount: NaN
type: Species
name: ACAA1
constant: false
is: SBO:0000252

metaM andrstandn r
constant: false
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
initial concentration: 1.0
is: CHEBI:15994
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
type: Species
has only substance units: false
is: HMDB00899

metaM ksi deg12 l
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 12
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaM hdd2coa x
is: HMDB03945
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
constant: false

metaR ACETONEt2m
name: acetone mitochondrial transport via proton symport
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8fb283f1_b58a_4b96_887e_d269f18517f7
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: NPR1
is: P16066
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4881

http://identifiers.org/biomodels.db/MODEL1310110030#_acc4c7b0_4b68_46fb_a969_599d38f6a795
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4247
is: Q10469
name: MGAT2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_6fdb6c08_bfae_4fd7_be05_8d97be56b52a
is: Q9NP56
name: PDE7B
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27115
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Folate

metaM amp m
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
has only substance units: false
name: AMP(2-)
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00045

metaM aps c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
is: CHEBI:58243
is: HMDB01003
type: Species
name: 5'-adenylyl sulfate(2-)
constant: false

metaR r1018
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
name: Transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f91a450b_d892_4c74_ac2b_fd40813c0166
is encoded by: hsa:2645
is: Q53Y25
has only substance units: false
is: SBO:0000252
name: GCK
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_67976654_e0d4_438b_a51f_e55cd680e1ed
type: Species
initial amount: NaN
is: Q9BV79
is encoded by: hsa:51102
is: SBO:0000252
boundary condition: true
has only substance units: false
name: MECR
initial concentration: NaN
constant: false

metaR ADPRDP
is version of: http://identifiers.org/ec-code/3.6.1.13
modifier: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11164.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.13 Confidence Level: 4 AUTHORS: PMID:10567213,PMID:10722730,PMID:12717453 NOTES:
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: ADPribose diphosphatase
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM CE2838 e
constant: false
is: http://identifiers.org/pubchem.compound/5041
is: C01936
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial amount: NaN
has only substance units: false
name: maltononaose
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM so3 c
type: Species
is: C00094
is: HMDB00240
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Sulfite

http://identifiers.org/biomodels.db/MODEL1310110030#_4dd73fbf_0d62_41c8_8d16_953e83980137
constant: false
is: O14556
type: Species
name: GAPDHS
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:26330
is: SBO:0000252
has only substance units: false

metaM sT antigen g
is: CHEBI:16565
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
name: sialyl-T antigen
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM CE0693 m
has only substance units: false
initial amount: NaN
type: Species
name: 3-oxolaur-6-cis-enoyl-CoA
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB11123
is: CHEBI:28387
constant: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693

http://identifiers.org/biomodels.db/MODEL1310110030#_c94637d8_d61f_4d0b_b7d4_399083beaa54
has only substance units: false
name: COX8A
is encoded by: hsa:1351
boundary condition: true
is: Q53XN1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_252d03b3_415a_426d_8b0f_86ae0947bbb6
has part: P15531
has only substance units: false
is encoded by: hsa:4830
name: NME1:NME2
is encoded by: hsa:4831
is: SBO:0000297
has part: P22392
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaM leuktrC4 e
boundary condition: false
is: HMDB01198
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57973
type: Species
name: leukotriene C4(2-)
has only substance units: false
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM HC02175 e
name: caprate
constant: false
initial amount: NaN
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r1019
fast: false
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_fa0f5fe2_9370_4b7a_9954_4083bfac2134
is: SBO:0000252
is: E7EPT3
name: ALDH7A1
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:501
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_1e397f18_39c3_49e6_a3e2_63af88afe4d0
is encoded by: hsa:8560
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: O15121
name: DEGS1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_da5e98a1_947f_4fd6_b630_e397ffb99eaf
is: SBO:0000252
initial concentration: NaN
is: P11310
is encoded by: hsa:34
initial amount: NaN
name: ACADM
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR 3HBCOAHLm
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_05263e66_7b28_456a_9a50_baab71da812b
type: Species
constant: false
has only substance units: false
name: _AA532636_1_m
is encoded by: hsa:AA532636
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0835
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110030#

metaR r0722
kinetic law: MODEL1310110030#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.3.12
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM pep m
is: C00074
has only substance units: false
is: HMDB00263
initial amount: NaN
name: Phosphoenolpyruvate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18021
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
boundary condition: false
type: Species

metaM odecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
is: HMDB01322
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:3793
initial amount: NaN

metaM xu5p D c
type: Species
boundary condition: false
name: D-xylulose 5-phosphate(2-)
is: HMDB00868
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57737
initial amount: NaN

metaM aprgstrn c
type: Species
constant: false
name: (20S)-20-hydroxypregn-4-en-3-one
boundary condition: false
is: HMDB03069
is: SBO:0000247
is: CHEBI:28453
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
initial concentration: 1.0
initial amount: NaN

metaM acrn m
boundary condition: false
is: HMDB00201
initial amount: NaN
constant: false
is: CHEBI:57589
is: SBO:0000247
type: Species
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_de71c22f_563d_4ecd_b874_76297b4e9432
boundary condition: true
initial amount: NaN
name: ESD
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: P10768
type: Species
is encoded by: hsa:2098

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM arachdcoa c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06523
initial amount: NaN
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
is: SBO:0000247
type: Species
name: arachidonoyl-CoA(4-)

metaR PItg
fast: false
product: MODEL1310110030#
name: phosphate transport, Golgi apparatus
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false

metaR r0119
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
fast: false
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110030#

metaR SERGLNNaEx
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110030#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
fast: false
reactant: MODEL1310110030#
is: SBO:0000185

metaR r0400
is: SBO:0000176
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

metaR RE1573M
name: RE1573
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR r0724
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true

metaR RE1897C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110030#
reversible: true
fast: false
type: Reaction
name: RE1897
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_e9279071_dc6f_473e_9f52_b4e2383883cf
is: SBO:0000252
has only substance units: false
name: PC
type: Species
boundary condition: true
is encoded by: hsa:5091
initial concentration: NaN
constant: false
is: P11498
initial amount: NaN

metaR FAOXC14C12x
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM sarcs m
name: Sarcosine
constant: false
is: HMDB00271
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15611
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
has only substance units: false
is: C00213
type: Species

metaR RE2998M
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110030#
name: RE2998
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_cce5ef71_cdfe_44fe_b0fb_69e05ca40a1e
initial amount: NaN
is: Q53TV9
constant: false
boundary condition: true
name: RPE
is encoded by: hsa:6120
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM aprgstrn e
is: HMDB03069
has only substance units: false
is: CHEBI:28453
name: (20S)-20-hydroxypregn-4-en-3-one
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR HYXNt
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
name: Hypoxanthine transport
reversible: true
fast: false

metaR r0267
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
reactant: MODEL1310110030#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_25236eb4_0221_481e_89ec_21eb5c2d7efb
boundary condition: true
has only substance units: false
name: B3GALNT1
constant: false
is encoded by: hsa:8706
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: O75752

metaM tsul m
is: CHEBI:16094
constant: false
is: HMDB00257
boundary condition: false
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
initial concentration: 1.0
type: Species
name: thiosulfate(2-)
initial amount: NaN

metaR r2506
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM cs b deg1 l
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: HMDB00812
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
has only substance units: false
is: CHEBI:16953

metaM m2gacpail hs r
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:16038
type: Species

metaR r0836
reversible: true
reactant: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110030#_c97f7b52_d215_491e_aed8_7a3a2e89f1fc
is encoded by: hsa:3158
boundary condition: true
constant: false
is: P54868
initial concentration: NaN
is: SBO:0000252
type: Species
name: HMGCS2
initial amount: NaN
has only substance units: false

metaM mal L c
is: SBO:0000247
is: HMDB00156
initial concentration: 1.0
constant: false
has only substance units: false
name: (S)-malate(2-)
boundary condition: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
initial amount: NaN

metaM acgam1p c
is: CHEBI:7125
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: N-Acetyl-D-glucosamine 1-phosphate
is: HMDB01367
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
has only substance units: false

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_127f6e9f_6327_466c_a582_e86f43278faf
is: A0PJM6
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1120
name: CHKB

metaR GPDDA1
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction

metaR r2507
is: SBO:0000185
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000

metaM m7mpdol L r
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37636
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_7913cf78_906e_4685_ad9a_a7c21979f78f
type: Species
boundary condition: true
name: PANK2
is: Q6P1K9
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_adfb17c0_8f97_412b_a502_2007d6714bd6
type: Species
name: ST3GAL3
is encoded by: hsa:6487
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaM so3 m
is: HMDB00240
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: hydrogensulfite
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0af9acbc_6196_4e7f_8873_3d016d8357db
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_09314263_12ce_4552_8943_ec2581f84466
type: Species
boundary condition: true
is: SBO:0000252
name: INPP5E
initial amount: NaN
constant: false
is encoded by: hsa:56623
initial concentration: NaN
has only substance units: false
is: Q9NRR6

http://identifiers.org/biomodels.db/MODEL1310110030#_d9577e5d_a1f0_4b29_9a64_aa037f799c49
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:55967
constant: false
is: SBO:0000252
is: F8VQS7
name: NDUFA12
has only substance units: false

metaM hs deg14 l
initial concentration: 1.0
boundary condition: false
name: heparan sulfate, degradation product 14
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
is: CHEBI:16126
constant: false

metaR r2508
reversible: true
is: SBO:0000185
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaR PRFGS
fast: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylformylglycinamidine synthase
product: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.3.5.3
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_03cb4f8a_ee10_48b1_a752_5d3b2f5f42ce
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
has part: B4E3E9
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
is: SBO:0000297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0f6aef82_b1ff_49b6_b1ab_e87cdabc0012
is: SBO:0000252
has only substance units: false
is: Q7KYS4
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: PDE4C
initial amount: NaN
is encoded by: hsa:5143

metaR r2509
reactant: MODEL1310110030#
reversible: true
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4b58ff4a_2348_4d57_8429_bc81dc549fa3
is: P37287
constant: false
is: SBO:0000252
is encoded by: hsa:5277
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: PIGA

metaR H2Otg
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: H2O transport, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR G14T19g
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_ace46601_db48_4bd6_987a_4ae042b8c7a9
is: SBO:0000252
boundary condition: true
name: ALPPL2
has only substance units: false
is encoded by: hsa:251
initial concentration: NaN
initial amount: NaN
is: P10696
type: Species
constant: false

metaR CYSGLUexR
type: Reaction
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
reversible: true
is described by: ECO:0000304
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR PHACCOAGLNAC
is: SBO:0000176
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110030#

metaR RE2269E
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE2269
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.21.39
type: Reaction
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM ha e
is: SBO:0000247
is: CHEBI:16336
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
type: Species
constant: false
has only substance units: false
name: hyaluronan
initial concentration: 1.0

metaM arachdcoa x
initial amount: NaN
name: arachidonoyl-CoA(4-)
boundary condition: false
is: HMDB06523
type: Species
is: CHEBI:57368
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaM odecoa m
is: CHEBI:57387
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
is: HMDB01322
initial concentration: 1.0

metaM leuktrB4 e
initial concentration: 1.0
name: leukotriene B4(1-)
has only substance units: false
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB01085

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR r0403
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110030#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0e9737a2_7bdb_432d_a30a_c3f23bd94555
is: SBO:0000252
name: _AI469183_1_x
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI469183

http://identifiers.org/biomodels.db/MODEL1310110030#_fa0834d4_6826_403c_b6d8_791cc94aeb73
is: Q7Z3X3
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:2799
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: GNS

metaM amp e
type: Species
constant: false
initial amount: NaN
is: CHEBI:456215
is: C00020
boundary condition: false
has only substance units: false
name: AMP
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: SBO:0000247

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR RE2541E
kinetic law: MODEL1310110030#
is: SBO:0000176
fast: false
name: RE2541
modifier: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
reversible: true

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM 1pipdn2c x
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
type: Species
name: 1-piperideine-2-carboxylate
initial concentration: 1.0
is: HMDB01084
initial amount: NaN
boundary condition: false
is: CHEBI:16187

http://identifiers.org/biomodels.db/MODEL1310110030#_909271e5_0974_42f6_9e6e_79701e7ad76f
is encoded by: hsa:PRO1933
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _PRO1933_1_m
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fcc2b350_e626_43f4_a6f4_3fa0cfdfcf4b
name: PIGM
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q9H3S5
is encoded by: hsa:93183
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_6aeb1773_66aa_4e37_95c7_eef521cd36cc
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P61457
initial concentration: NaN
is encoded by: hsa:5092
initial amount: NaN
constant: false
name: PCBD1

metaM ksi g
has only substance units: false
is: SBO:0000247
is: HMDB01014
constant: false
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
is: CHEBI:57255
name: keratan sulfate I
type: Species
initial amount: NaN

metaR NACHEX19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
fast: false
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal

metaR r0408
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_ea3e03e8_5873_449c_b29c_89c190f5738b
initial concentration: NaN
has only substance units: false
name: _AU149534_1_e
initial amount: NaN
is encoded by: hsa:AU149534
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaR RBTt
kinetic law: MODEL1310110030#
reversible: false
name: ribitol transport via passive diffusion
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4f7c82c2_d865_4988_b9f4_4fbb0141f39b
boundary condition: true
has only substance units: false
name: _AI684467_1_m
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AI684467
initial concentration: NaN

metaR CHOLESTle
reversible: false
name: hydrolysis of cholesterol ester by cholesterol esterase
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.13
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176

metaR ATPtx
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_5074f7dd_38d9_4557_84e6_8c4d942c2017
has only substance units: false
constant: false
name: UAP1L1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q3KQV9
type: Species
is: SBO:0000252
is encoded by: hsa:91373

http://identifiers.org/biomodels.db/MODEL1310110030#_69e2340a_6c3d_4db2_906b_65e63c2aee63
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229
has only substance units: false
initial amount: NaN
is: Q9NVE7
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR CERT2gt
reversible: true
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
name: ceramide transport protein
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110030#
fast: false

metaR GTHPm
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase, mitochondria
is described by: ECO:0000269
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.12
modifier: MODEL1310110030#
is: SBO:0000176
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_2c6190f5_84d1_432a_8b9c_ae562f715929
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AA526438_1_c
initial concentration: NaN
is encoded by: hsa:AA526438
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_65b298f3_dabc_4eaf_9838_fe2493c1ad65
has only substance units: false
type: Species
name: _206_1_c
initial amount: NaN
is encoded by: hsa:206
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fdbbd827_0836_419e_b23c_06ed2ad6cbe0
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: O76062
name: TM7SF2
initial amount: NaN
is encoded by: hsa:7108
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b232db45_2a93_45ec_b2f4_1379c9a08d15
initial concentration: NaN
type: Species
initial amount: NaN
is: Q5T4Y1
has only substance units: false
constant: false
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true
name: ST3GAL3

metaR r1935
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction

metaM amp c
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:3322
initial concentration: 1.0
is: C00020
name: AMP
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110030#_f7da4bc3_973e_49c3_a058_46c6027392a2
is encoded by: hsa:3033
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: Q16836
boundary condition: true
is: SBO:0000252
name: HADH
has only substance units: false

metaM txa2 e
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
is: CHEBI:57445
initial concentration: 1.0
type: Species
is: SBO:0000247
name: thromboxane A2(1-)
boundary condition: false

metaR ACALDtm
name: acetaldehyde mitochondrial diffusion
reactant: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false

metaM leuktrB4 c
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: leukotriene B4(1-)
has only substance units: false
is: HMDB01085
type: Species

metaR G3PD1
reversible: true
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
kinetic law: MODEL1310110030#
fast: false
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.8

metaM ak2lgchol hs c
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
is: C04317
is: http://identifiers.org/pubchem.compound/6975

metaM ksi e
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17268
name: keratan sulfate I
constant: false
is: HMDB00211
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_343df66b_dae4_4e66_a559_4c16663cec83
name: ALG1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:56052
is: SBO:0000252
is: Q9BT22

metaR PItn
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: phosphate transport, nuclear
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
type: Reaction

metaR COt
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
name: CO transporter via diffusion
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV

metaR DHFR
type: Reaction
name: dihydrofolate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8fb161e4_3cb0_4268_9b1e_96eb421300c8
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: D3DX95
constant: false
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252
type: Species
has only substance units: false

metaR r1651
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110030#

metaM hdd2coa m
is: CHEBI:61526
constant: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
has only substance units: false
is: HMDB03945
type: Species
is: C05272
initial amount: NaN
name: trans-Hexadec-2-enoyl-CoA
boundary condition: false

metaR TPI
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110030#
name: triose-phosphate isomerase
reversible: true
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.3.1.1

metaM ficytC m
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
name: Ferricytochrome c
is: SBO:0000247
has only substance units: false
is: CHEBI:15991
constant: false

metaR DNDPt27m
is described by: ECO:0000269
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
type: Reaction
kinetic law: MODEL1310110030#
name: dCDP transport via dTDP antiport
modifier: MODEL1310110030#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM txa2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
name: thromboxane A2(1-)
is: CHEBI:57445
has only substance units: false
initial amount: NaN
is: HMDB01452
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_b5848002_739c_4b19_9453_a5b954660c92
name: PRDX2
is encoded by: hsa:7001
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaM udpacgal c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00304
is: CHEBI:57847

metaM ksi pre23 g
type: Species
is: CHEBI:28067
initial concentration: 1.0
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
is: SBO:0000247

metaR SIAT9g
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.9
reversible: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction

metaR r0407
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is: SBO:0000176
product: MODEL1310110030#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
modifier: MODEL1310110030#

metaR r1650
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#

metaR SERCYSNaEx
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
fast: false
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_092d30bd_4dee_48e2_bbed_befe732b64fb
is: SBO:0000252
is encoded by: hsa:376497
name: SLC27A1
has only substance units: false
type: Species
initial concentration: NaN
is: Q6PCB7
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cc3bdf91_00e6_41db_bf34_fd472e994ee6
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
name: SLC7A10:SLC3A2
has only substance units: false
has part: Q9NS82
is encoded by: hsa:56301
constant: false
initial concentration: NaN
has part: P08195
is encoded by: hsa:6520

metaM acrn c
initial concentration: 1.0
is: HMDB00201
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: O-acetylcarnitine
is: CHEBI:57589
is: SBO:0000247

metaM sphs1p c
is: CHEBI:60119
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB00277
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species

metaR ACALDtx
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
name: acetaldehyde peroxisomal diffusion
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_1e7aaa90_0ca2_457c_963f_662205ee919c
name: GBA
initial concentration: NaN
boundary condition: true
is: B7Z6S9
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:2629
is: SBO:0000252

metaM lac D c
has only substance units: false
name: (R)-lactate
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
type: Species
boundary condition: false
is: HMDB01311
initial concentration: 1.0
is: CHEBI:16004
is: SBO:0000247
constant: false

metaM Lpipecol x
initial amount: NaN
is: CHEBI:30913
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: L-pipecolic acid
is: HMDB00716
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

metaR AIRCr
product: MODEL1310110030#
is described by: ECO:0000269
name: phosphoribosylaminoimidazole carboxylase
reversible: true
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.6
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fe4a9fc2_b600_4671_bb9c_c29c649d62f1
initial amount: NaN
is: SBO:0000252
name: ACAD8
boundary condition: true
is: Q6ZWP6
is encoded by: hsa:27034
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM mi145p c
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: SBO:0000247
is: CHEBI:203600
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
constant: false
is: HMDB01498

metaM hs deg7 l
name: heparan sulfate, degradation product 7
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: HMDB06254
type: Species
is: SBO:0000247
constant: false

metaM Rtotal2 c
initial concentration: 1.0
name: R total 2 position
constant: false
initial amount: NaN
is: C00055
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: HMDB00095
type: Species
is: CHEBI:60377
is: SBO:0000247
boundary condition: false

metaR S6T17g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d79d7ab6_770e_40af_ae88_33994dab4beb
is: Q68CJ7
is encoded by: hsa:131669
is: SBO:0000252
has only substance units: false
boundary condition: true
name: UROC1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_18586608_2d41_46ff_8dbb_c43c9f0c037a
is: SBO:0000252
name: SLC5A2
constant: false
has only substance units: false
initial amount: NaN
is: P31639
type: Species
is encoded by: hsa:6524
initial concentration: NaN
boundary condition: true

metaR RDH2
is described by: ECO:0000269
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
type: Reaction
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (9-cis,NADH)
is: SBO:0000176

metaR r1653
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_33276f73_5733_4b91_904a_090ac166a205
has only substance units: false
name: GMPR2
is: Q9P2T1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51292
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8fa2b625_808b_4427_bd19_f55f294c812b
initial concentration: NaN
has only substance units: false
is: B2RBR4
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6575
name: SLC20A2
constant: false
initial amount: NaN

metaM cs a deg2 l
initial amount: NaN
is: HMDB00127
type: Species
is: SBO:0000247
is: CHEBI:15748
initial concentration: 1.0
has only substance units: false
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_3f12e8dc_e96c_469d_91df_4081f6577dd1
type: Species
boundary condition: true
is: A8K0I1
initial amount: NaN
name: DGKH
is encoded by: hsa:160851
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR GLYCtm
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
name: glycerol transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_c1f1d0a1_0c13_414d_b2d6_7618002606e6
is: Q6PXP3
is encoded by: hsa:155184
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC2A7
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_515fe8d9_15b7_46d7_8661_39bcd7ad9c87
name: B3GALNT1
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:8706
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B3KTQ4
type: Species

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR DOLPMT L
name: Dolichyl-phosphate D-mannosyltransferase (liver)
modifier: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.83
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR FE3MTP1
name: transport of ferrous iron into blood
reversible: false
fast: false
product: MODEL1310110030#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000134

metaR r0558
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110030#

metaR H2Otp
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000185
reversible: true
fast: false
name: H2O transport, peroxisomal
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM hmgcoa x
is: HMDB01375
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_5ee20215_bf9d_46a7_ab8d_620f485feb1d
is encoded by: hsa:2819
name: GPD1
is: F8W1L5
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR RDH3
kinetic law: MODEL1310110030#
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
is: SBO:0000176
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: retinol dehydrogenase (11-cis,NADH)

metaR 5ADTSTSTERONEte
type: Reaction
reversible: true
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport
product: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
kinetic law: MODEL1310110030#

metaM udpacgal g
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
is: HMDB00304
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110030#_598005b0_9ccf_4140_b2b0_a6b21221f41f
is encoded by: hsa:2591
is: Q14435
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: GALNT3

metaR GLCAASE1ly
reactant: MODEL1310110030#
fast: false
name: beta-glucuronidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR PACCOAL
kinetic law: MODEL1310110030#
name: phenylacetate-CoA ligase
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: false
product: MODEL1310110030#

metaM lac D e
initial amount: NaN
is: HMDB01311
type: Species
name: (R)-lactate
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
is: CHEBI:16004
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_798ea606_a8b2_44a8_9a6f_8475c7b6c25a
name: NDUFA7
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4701
is: Q6FG42
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_e45384d7_4c1f_4261_bcba_0bb8e7296d3b
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q02218
constant: false
has only substance units: false
boundary condition: true
name: OGDH
is encoded by: hsa:4967

metaM 3dpdhb m
name: 3-Decaprenyl-4,5-dihdydroxybenzoate
is: CHEBI:50775
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C57H85O4 CHARGE: -1 INCHI: InChI=1S/C57H86O4/c1-43(2)21-12-22-44(3)23-13-24-45(4)25-14-26-46(5)27-15-28-47(6)29-16-30-48(7)31-17-32-49(8)33-18-34-50(9)35-19-36-51(10)37-20-38-52(11)39-40-53-41-54(57(60)61)42-55(58)56(53)59/h21,23,25,27,29,31,33,35,37,39,41-42,58-59H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,60,61)/b44-23+,45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+

metaM lnlncgcoa c
initial concentration: 1.0
is: SBO:0000247
is: HMDB06368
type: Species
name: gamma-linolenoyl-CoA(4-)
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57363
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaR r1655
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_cc0dcc8a_faca_4a48_b802_941d0e03a258
is: P23434
is encoded by: hsa:2653
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: GCSH

metaM Rtotal2 e
initial concentration: 1.0
name: R total 2 position
is: C00255
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: CHEBI:3554
is: SBO:0000247
has only substance units: false
is: HMDB00244
boundary condition: false
constant: false
initial amount: NaN

metaR SIAASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110030#

metaM gm3 hs g
type: Species
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
has only substance units: false
constant: false
is: CHEBI:60065

http://identifiers.org/biomodels.db/MODEL1310110030#_64125fdb_dae5_4ce4_b615_0ed54bf27d18
is encoded by: hsa:3032
constant: false
is: P55084
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: HADHB

metaR PROD2
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
reversible: false
is: SBO:0000176
name: Proline dehydrogenase
modifier: MODEL1310110030#
is described by: ECO:0000254
product: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6295cc59_957d_4642_b4f6_1f8669942cf6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:771
name: CA12
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_49e68852_dcb0_4902_ac14_4fd8d7703310
is encoded by: hsa:10317
has only substance units: false
type: Species
initial concentration: NaN
name: B3GALT5
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaM ak2lgchol hs e
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
type: Species
is: SBO:0000247
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
is: http://identifiers.org/pubchem.compound/6975
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: C04317

http://identifiers.org/biomodels.db/MODEL1310110030#_ade6a5f1_edb3_4fbb_98d5_fa9a13975b16
initial amount: NaN
is: P03897
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4537
has only substance units: false
constant: false
name: ND3
is: SBO:0000252

metaR r0556
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false
reversible: true
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.19.1

metaM itaccoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: HMDB03377
name: itaconyl-CoA(5-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57381
constant: false

metaM kynate c
is: HMDB00715
has only substance units: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
type: Species
constant: false
is: CHEBI:58454
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: kynurenate

metaR H2Otn
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: H2O transport, nuclear
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8233f792_be7c_428b_a159_5e12bbe0688d
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:10858
type: Species
boundary condition: true
name: CYP46A1
initial concentration: NaN
is: Q9Y6A2
is: SBO:0000252

metaR r1933
kinetic law: MODEL1310110030#
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

metaR r1654
modifier: MODEL1310110030#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

metaR RDH1
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
name: retinol dehydrogenase (all-trans)
reversible: true
type: Reaction
product: MODEL1310110030#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110030#

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM 6dhf e
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR MGSA2
reactant: MODEL1310110030#
is: SBO:0000176
name: methyglyoxylate synthase 2 (from g3p)
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reversible: false
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD

metaR ADNt
kinetic law: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: adenosine facilated transport in cytosol
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
fast: false
modifier: MODEL1310110030#
reversible: true
type: Reaction

metaR P4507A1r
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.17

http://identifiers.org/biomodels.db/MODEL1310110030#_bc230f94_96c5_4767_b2f8_038635446f5c
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
is: P15328
name: FOLR1
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaM dgchol e
initial amount: NaN
is: CHEBI:36252
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00637
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
name: glycochenodeoxycholate

metaR r1364
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaR r1657
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaR H2Otm
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
modifier: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
name: H2O transport, mitochondrial
product: MODEL1310110030#

metaR r0553
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176

metaM ksii core4 deg3 l
name: keratan sulfate II (core 4-linked), degradation product 3
is: CHEBI:12936
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: HMDB00143
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_bd9ed792_c1e9_4ca8_8279_9a5cf534ab7c
initial concentration: NaN
name: SPTLC1
is: O15269
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10558
initial amount: NaN
type: Species
constant: false

metaM meoh c
is: SBO:0000247
boundary condition: false
type: Species
name: methanol
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17790
is: HMDB01875
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
initial concentration: 1.0

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_c0d5555a_9c13_479b_94ab_01776b618ddf
constant: false
initial concentration: NaN
initial amount: NaN
name: _AA502753_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA502753
type: Species

metaR LEUt5m
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM gdpmann c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: HMDB01163
has only substance units: false
is: CHEBI:57527

http://identifiers.org/biomodels.db/MODEL1310110030#_eb6e7078_fcca_44c4_96d3_9978647ea788
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q96P26
name: NT5C1B
is encoded by: hsa:93034
has only substance units: false
boundary condition: true

metaR DOLMANP Uter
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaR r1656
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM arachdcoa r
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
type: Species
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
is: HMDB06523
constant: false

metaM ocdca e
name: octadecanoate (n-C18:0)
boundary condition: false
has only substance units: false
constant: false
is: C01530
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:25629
initial amount: NaN
is: HMDB00827
type: Species

metaR SARCStex
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
is described by: ECO:0000000
name: Sarcosine transport (extracellular to cytosol)
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction

metaR AATAi
name: 2-aminoadipate transaminase, irreversible
reversible: false
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
kinetic law: MODEL1310110030#

metaR ARGtm
is: SBO:0000185
name: arginine mitochondrial transport via ornithine carrier
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR UDPG4E
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
kinetic law: MODEL1310110030#

metaM dcdp m
is: CHEBI:58593
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
constant: false

metaM ksi l
initial concentration: 1.0
type: Species
is: C00445
boundary condition: false
name: keratan sulfate I
is: CHEBI:57455
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
is: HMDB01354
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_5586cff2_f1b7_44f1_8f0d_aa95a119d91c
is encoded by: hsa:2530
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: FUT8
constant: false
is: Q9BYC5
type: Species
initial amount: NaN
boundary condition: true

metaM m2mpdol L c
is: CHEBI:28049
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
type: Species
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

metaM nh4 x
is: CHEBI:28938
type: Species
initial amount: NaN
name: Ammonium
is: SBO:0000247
is: C01342
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: HMDB00051
initial concentration: 1.0
boundary condition: false

metaR MANt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
type: Reaction
name: D-mannose transport via sodium cotransport
is described by: ECO:0000269

metaM dgchol c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:36252
initial concentration: 1.0
name: glycochenodeoxycholate
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
is: SBO:0000247

metaM malttr e
initial concentration: 1.0
initial amount: NaN
name: maltotriose
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: C01835
is: CHEBI:27931
type: Species

metaR LNLNCAt
fast: false
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
name: fatty acid transport via diffusion

metaR SERtN1
kinetic law: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: Serine transport (Na, H coupled)
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_1ed4272b_bd3e_428a_9fb4_54550c8076d6
is encoded by: hsa:55163
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PNPO
is: Q9NVS9
has only substance units: false
constant: false

metaM udpacgal l
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
initial concentration: 1.0
boundary condition: false

metaR GLCt4
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: glucose transport via sodium symport
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_2c4fabe1_8876_43ff_ae92_e98a79707ca0
boundary condition: true
is: P23743
is: SBO:0000252
has only substance units: false
name: DGKA
initial amount: NaN
is encoded by: hsa:1606
constant: false
type: Species
initial concentration: NaN

metaR r1659
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true

metaR GLYt2r
is: SBO:0000185
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110030#
is described by: ECO:0000304
type: Reaction
name: glycine reversible transport via proton symport
reactant: MODEL1310110030#
reversible: true
fast: false

metaM meoh e
initial concentration: 1.0
name: methanol
is: HMDB01875
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17790
constant: false
type: Species
boundary condition: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132

metaM dcdp n
type: Species
is: HMDB01245
has only substance units: false
initial amount: NaN
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58593
is: SBO:0000247

metaR PItx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110030#
name: Phosphate transporter, peroxisome
fast: false

metaR AG13T2g
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false

metaR ATPtm
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
name: ADP/ATP transporter, mitochondrial
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: false
type: Reaction

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8b35a143_f2eb_49f0_a974_ca3f0bb0807b
is: Q8WZ48
name: CPT1A
initial concentration: NaN
type: Species
is encoded by: hsa:1374
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM ksi deg23 l
name: keratan sulfate I, degradation product 23
has only substance units: false
is: CHEBI:12936
constant: false
boundary condition: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143

metaR r1658
modifier: MODEL1310110030#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
reversible: true
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2de2c991_e798_4f9b_983c_13ad9872435a
initial concentration: NaN
initial amount: NaN
type: Species
name: CYP27A1
is: Q02318
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1593

metaM ocdca c
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: stearate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
is: HMDB00827
constant: false
is: CHEBI:25629

metaR r0552
fast: false
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110030#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1

metaR r0841
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
name: Free diffusion
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110030#
type: Reaction
fast: false

metaR DGCHOLte
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110030#
name: bile acid intracellular transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_643bf515_ff76_4b24_908f_82ce52578d9d
boundary condition: true
initial amount: NaN
name: AUH
is encoded by: hsa:549
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q13825
constant: false

metaM CE2243 c
type: Species
constant: false
boundary condition: false
is: CHEBI:52324
has only substance units: false
name: trans-eicos-2-enoyl-CoA
notes: FORMULA: C41H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h20-21,28-30,34-36,40,51-52H,4-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE2243
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR C226CRNt
is: SBO:0000185
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110030#
name: C226 transport into the mitochondria
type: Reaction

metaR PPD2CSPp
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: false
fast: false
type: Reaction
name: PPD2CSPp
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM

metaR FAOXC160
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110030#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000269
type: Reaction

metaM xoltriol m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16496
is: HMDB01457
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
constant: false
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN

metaM xoldiolone c
initial concentration: 1.0
is: CHEBI:28477
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR SMPD4
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
product: MODEL1310110030#
name: sphingomyelinase

metaR r0840
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.70
fast: false
name: Free diffusion
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB02710
is: CHEBI:27485

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27428
constant: false
boundary condition: false

metaM thcholstoic c
is: HMDB03873
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
type: Species
is: CHEBI:18402
initial concentration: 1.0
has only substance units: false

metaR A4GALTg
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.228
reactant: MODEL1310110030#
is described by: ECO:0000269
name: Lactosylceramide 4-alpha-galactosyltransferase
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
reversible: false
product: MODEL1310110030#

metaM glc D e
boundary condition: false
has only substance units: false
is: HMDB00122
type: Species
name: D-glucose
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
is: CHEBI:4167
constant: false

metaR S6T6g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_18815256_d704_431c_ba54_567054a3b01d
is: SBO:0000252
name: DGKB
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1607
is: Q9Y6T7
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR r0149
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_8ff41418_5dd0_4773_943d_30cafcbac326
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:178
constant: false
name: AGL

metaM citr L m
has only substance units: false
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
initial concentration: 1.0
is: HMDB00904
type: Species
initial amount: NaN
constant: false
name: L-citrulline
boundary condition: false

metaR SR5ARr
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
reversible: false
kinetic law: MODEL1310110030#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.5
reactant: MODEL1310110030#
is described by: ECO:0000134
fast: false

metaM ksi pre18 g
is: SBO:0000247
constant: false
is: HMDB00175
is: CHEBI:58053
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 18
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110030#_e6afeeea_efcc_4432_9214_4d15a9d6d20f
name: DPM2
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: O94777
is: SBO:0000252
constant: false
is encoded by: hsa:8818
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_961bc0e0_06e8_47ca_903d_4b6ff14fcc5b
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3417
is: O75874
boundary condition: true
name: IDH1
is: SBO:0000252
initial amount: NaN
type: Species

metaM sprm e
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: spermine(4+)
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: HMDB01256
is: CHEBI:45725
boundary condition: false

metaR r1628
fast: false
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#

metaR GALASE10ly
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110030#
is: SBO:0000176

metaR DOLPH Ler
name: Dolichol-phosphate phosphohydrolase, human (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_57a74fbe_4e43_489e_983a_dee736b1e046
is: SBO:0000252
is: Q9Y6L6
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10599
has only substance units: false
constant: false
initial concentration: NaN
name: SLCO1B1

http://identifiers.org/biomodels.db/MODEL1310110030#_320a8b55_beb1_4292_b4c7_6d8b85f3e6c2
initial concentration: NaN
is: SBO:0000252
type: Species
is: P24539
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:515
name: ATP5F1
initial amount: NaN

metaM dha e
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
is: CHEBI:16016
has only substance units: false
type: Species
is: HMDB01882
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR S6T14g
reversible: false
modifier: MODEL1310110030#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR r1629
fast: false
reactant: MODEL1310110030#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_9aa87c95_f0e6_4794_a0ea_d4e5ac002c3e
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5837
name: PYGM
is: P11217
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_cecc2322_c7c3_4e28_a6bc_076b0cb66dce
initial concentration: NaN
boundary condition: true
name: DLST
constant: false
has only substance units: false
is encoded by: hsa:1743
type: Species
initial amount: NaN
is: SBO:0000252
is: P36957

metaM HC02202 c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: prostaglandin A1(1-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57398
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

http://identifiers.org/biomodels.db/MODEL1310110030#_520d7c6d_3536_4d95_bde5_3a21cff03983
constant: false
is encoded by: hsa:349565
initial concentration: NaN
has only substance units: false
name: NMNAT3
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q96T66
type: Species

metaM ksii core4 pre3 g
is: C00130
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: SBO:0000247

metaR KYNATESYN
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_440d590d_a1c7_438d_acb8_fd8591659cec
is encoded by: hsa:79717
constant: false
type: Species
has only substance units: false
is: Q9HAB8
name: PPCS
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR RE0689E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110030#
name: RE0689
type: Reaction

metaM prpncoa m
is: HMDB02307
has only substance units: false
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57367
name: acryloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110030#_1bf64f9b_8839_40bc_81ae_bac7718e7db0
is: Q9NRA0
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SPHK2
constant: false
is encoded by: hsa:56848
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_26a817c1_d237_4123_86ac_70f2fa43f238
initial amount: NaN
boundary condition: true
name: NDUFA4L2
is: SBO:0000252
is: Q9NRX3
has only substance units: false
constant: false
is encoded by: hsa:56901
initial concentration: NaN
type: Species

metaR r1626
fast: false
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6b235d6b_4c7d_42cf_a5e5_52d2e02c2a9a
name: PPA2
is: SBO:0000252
constant: false
is: F8WDN9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:27068
initial amount: NaN
type: Species
boundary condition: true

metaR r2079
product: MODEL1310110030#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
is: SBO:0000185
fast: false
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6da30b00_14a3_42b7_bfc6_1396ea31d6c3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:H17063
boundary condition: true
constant: false
name: _H17063_1_c
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_40059504_e679_4a61_a1c8_6f06b71eda6b
constant: false
has only substance units: false
is: SBO:0000252
name: CTPS2
type: Species
is encoded by: hsa:56474
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9NRF8

http://identifiers.org/biomodels.db/MODEL1310110030#_70be593a_d49d_4eb2_91b8_9131d01b4fc7
has only substance units: false
initial concentration: NaN
constant: false
name: LDHD
is encoded by: hsa:197257
boundary condition: true
is: SBO:0000252
type: Species
is: Q86WU2
initial amount: NaN

metaM 2mbcoa m
is: CHEBI:57336
is: HMDB01041
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_c4784367_8621_4b0d_ad81_d895941bd54e
boundary condition: true
is: Q9NR34
initial concentration: NaN
is encoded by: hsa:57134
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: MAN1C1

metaR NTD10
kinetic law: MODEL1310110030#
name: 5'-nucleotidase (XMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
fast: false
product: MODEL1310110030#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110030#_0c14a728_4851_4d66_82d0_70075f9b5443
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2181
constant: false
boundary condition: true
has only substance units: false
name: ACSL3
initial amount: NaN
is: O95573

http://identifiers.org/biomodels.db/MODEL1310110030#_1d448ba5_09c5_4183_b0c2_957451b6b1a0
is: SBO:0000252
is: P16278
type: Species
constant: false
is encoded by: hsa:2720
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GLB1
has only substance units: false

metaR r1627
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
fast: false

metaR 3MOBte
reversible: true
type: Reaction
is described by: ECO:0000134
name: Transport of 3-methyl-2-oxobutanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is: SBO:0000185

metaM ile L e
constant: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
is: CHEBI:17191
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: L-isoleucine
has only substance units: false

metaM s7p c
has only substance units: false
is: HMDB01068
type: Species
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: CHEBI:57483
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: C05382
name: Sedoheptulose 7-phosphate
initial concentration: 1.0

metaM HC02202 e
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57398
name: prostaglandin A1(1-)
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
constant: false

metaR AGDC
product: MODEL1310110030#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: N-acetylglucosamine-6-phosphate deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.25
notes: GENE_ASSOCIATION: (51005.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.1.25 Confidence Level: 2 AUTHORS: NOTES:acetylglucosamine phosphate deacetylase; acetylaminodeoxyglucosephosphate acetylhydrolase; 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase
reactant: MODEL1310110030#

metaR RE0830N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
name: RE0830
type: Reaction
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR PI45P5P
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
product: MODEL1310110030#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
fast: false

metaR PRPNCOAHYDm
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

metaM 6pgl c
is: C01236
initial concentration: 1.0
notes: FORMULA: C6H9O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57955
is: HMDB01127
constant: false
boundary condition: false
type: Species
name: 6-phospho-D-glucono-1,5-lactone

http://identifiers.org/biomodels.db/MODEL1310110030#_2f36e2b2_f9e6_4122_979d_e6208b1933f7
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _NOS2A_1_c
type: Species
is encoded by: hsa:NOS2A

http://identifiers.org/biomodels.db/MODEL1310110030#_74377091_67d7_4c05_aa63_7fd7cd0c9f8f
name: BLVRB
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:645
constant: false
is: P30043
initial concentration: NaN
is: SBO:0000252

metaR r1624
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#

metaR NACHEX24ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_96545cc6_f9dc_4d13_8e39_c2ca1b1e8d0f
boundary condition: true
name: ECI2
initial amount: NaN
initial concentration: NaN
constant: false
is: O75521
is encoded by: hsa:10455
has only substance units: false
type: Species
is: SBO:0000252

metaR FOLt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110030#
reversible: true
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000134
name: folate transport via anion exchange

metaM ptth c
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
has only substance units: false
is: CHEBI:16753
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: pantetheine
constant: false
type: Species

metaM Asn X Ser Thr r
is: CHEBI:28938
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00051
has only substance units: false
name: protein-linked asparagine residue (N-glycosylation site)
constant: false
is: C01342
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_c992bda5_09ca_469e_b5c4_ec97cd7c04d8
initial concentration: NaN
is encoded by: hsa:4645
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q9H6Y6
name: MYO5B
boundary condition: true

metaR VALTAm
name: valine transaminase, mitochondiral
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8c453cfa_cbe8_474c_b85b_3fd60201aaa0
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: SLC26A9
constant: false
is encoded by: hsa:115019
is: SBO:0000252
is: B3KXK1
boundary condition: true

metaR r1625
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110030#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#

metaM HC01444 e
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:15754
is: SBO:0000247
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
has only substance units: false
initial concentration: 1.0
name: Galactosylglycerol

metaR GACPAILter
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
reversible: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD

metaR PNTEH
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.1.92
fast: false
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
name: Hydrolase Class ( RXN R02973)
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110030#

metaM gcald c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial amount: NaN
type: Species
name: glycolaldehyde
is: HMDB03344
is: CHEBI:17071
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f4b44080_2636_4d58_a5af_e781c0c8efac
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1347
name: COX7A2
is: H0UI06
type: Species
has only substance units: false
is: SBO:0000252

metaR r0994
name: Facilitated diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

metaR FAEL183
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
product: MODEL1310110030#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
type: Reaction

metaR MDHm
fast: false
is: SBO:0000176
type: Reaction
name: malate dehydrogenase, mitochondrial
is described by: ECO:0000134
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM ile L c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: L-isoleucine
type: Species
boundary condition: false
is: HMDB00172
has only substance units: false
is: CHEBI:17191
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

http://identifiers.org/biomodels.db/MODEL1310110030#_13dbe8ee_21c2_44b0_a8cb_e76478ede6f9
name: DHFR
type: Species
is: SBO:0000252
is encoded by: hsa:1719
constant: false
is: P00374
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5d28a0cf_82ba_4add_9400_b2a7c0de3f8d
is: P28330
is encoded by: hsa:33
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: ACADL
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7050c754_9964_4d66_ac6a_40d3c502ce84
type: Species
is: Q96RV2
has only substance units: false
boundary condition: true
initial amount: NaN
name: HAS3
initial concentration: NaN
is encoded by: hsa:3038
constant: false
is: SBO:0000252

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:18022
boundary condition: false
is: HMDB01453

metaM xol7aone r
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
is: CHEBI:17899
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one

metaM dolp L r
has only substance units: false
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: dolichyl phosphate(2-)
is: CHEBI:57683
constant: false

metaM paf hs e
has only substance units: false
is: CHEBI:36707
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
type: Species

metaM hs deg10 l
name: heparan sulfate, degradation product 10
is: HMDB00127
constant: false
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM xoltriol c
is: HMDB01457
is: CHEBI:16496
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaR RE2626M
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000176
reversible: true
name: RE2626
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7b89cd89_f7c5_475c_a5ee_8bfbb2716583
type: Species
is encoded by: hsa:4731
has only substance units: false
constant: false
is encoded by: hsa:4712
boundary condition: true
has part: Q5VYT2
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaM paf hs c
boundary condition: false
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaM sphgn c
type: Species
is: SBO:0000247
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
name: sphinganine(1+)
boundary condition: false
initial concentration: 1.0
is: HMDB00269
has only substance units: false
initial amount: NaN
is: CHEBI:57817

http://identifiers.org/biomodels.db/MODEL1310110030#_559172a5_6d11_4f04_8415_eafe30af120d
type: Species
boundary condition: true
is: Q59FD4
constant: false
initial concentration: NaN
is encoded by: hsa:3098
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: HK1

http://identifiers.org/biomodels.db/MODEL1310110030#_1e583223_7e39_4c1a_9fda_8a2c5b2eb719
initial concentration: NaN
is: B7Z4Y6
is encoded by: hsa:249
type: Species
boundary condition: true
initial amount: NaN
name: ALPL
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e7217a2c_8949_4228_ad72_4dc233d318ae
type: Species
initial amount: NaN
name: MPO
boundary condition: true
is encoded by: hsa:4353
initial concentration: NaN
constant: false
has only substance units: false
is: P05164
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_6251797c_98c2_4155_81e3_2115227a8fae
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10682
name: EBP
boundary condition: true
type: Species
is: Q15125
has only substance units: false
constant: false

metaM tre e
is: SBO:0000247
is: HMDB00975
has only substance units: false
initial concentration: 1.0
is: CHEBI:16551
constant: false
name: Trehalose
boundary condition: false
is: C01083
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_6f56411e_3bed_4f15_b04f_f0715601764b
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AA278423_1_m
is encoded by: hsa:AA278423
has only substance units: false
initial amount: NaN

metaM lnlncgcoa r
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
is: SBO:0000247
is: CHEBI:57363
constant: false
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR AG13T17g
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM ksi deg27 l
initial concentration: 1.0
type: Species
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 27

metaM tcynt e
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: thiocyanate
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: CHEBI:18022
is: HMDB01453
boundary condition: false

metaR GLCNACASE1ly
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_820a0c33_41df_4297_a673_ab7b541d5c61
boundary condition: true
constant: false
name: ST3GAL3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6487
type: Species
is: Q11203

http://identifiers.org/biomodels.db/MODEL1310110030#_9be4a27b_861d_4496_8359_fd004b1d958b
type: Species
constant: false
name: ATP5H
is encoded by: hsa:10476
is: A0PJH2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d9bdd25c_9c39_4284_b23e_ad5757a14123
is: P09972
type: Species
is: SBO:0000252
is encoded by: hsa:230
name: ALDOC
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM citr L e
initial concentration: 1.0
is: HMDB00904
name: citr_L[e]
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaR RE0830C
product: MODEL1310110030#
is described by: ECO:0000000
name: RE0830
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110030#
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_bb9e1123_455c_4376_92c1_f2d19f23ff3e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
constant: false
name: VNN3
initial amount: NaN
type: Species

metaR G14T18g
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_6ba89605_39d8_4fc2_91cf_597a32a2cf91
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q96G03
name: PGM2
is encoded by: hsa:55276
has only substance units: false

metaR B3GALT5g
reversible: false
name: Beta-1,3-galactosyltransferase 5
product: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110030#
is described by: ECO:0000269
fast: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM Asn X Ser Thr l
type: Species
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C01342
is: CHEBI:28938
initial amount: NaN
is: HMDB00051
notes: FORMULA: XH CHARGE: 0

metaM cholp c
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:295975
name: choline phosphate(1-)
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

metaM dcacoa m
initial concentration: 1.0
is: C05274
has only substance units: false
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06404
is: CHEBI:61430
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

metaR HACD9m
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110030#_b92d21c4_a478_43ec_96f8_9a26baea2610
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q8TCG5
is encoded by: hsa:126129
name: CPT1C
constant: false
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a40bd7d9_3c51_4ef9_9c62_6be2a7a01c27
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4704
is: SBO:0000252
name: NDUFA9
boundary condition: true
is: Q16795
has only substance units: false

metaR FORt2m
reversible: true
type: Reaction
name: formate mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD,IT
fast: false
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

metaM 1p3h5c m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01369
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false

metaR RE1522M
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE1522
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110030#

metaR 3AIB Dtm
type: Reaction
is described by: ECO:0000134
reversible: true
name: transport of 3aib_D into mitochondria
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_2c818eec_39c7_497d_9142_d8fe6cef7475
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: SLCO3A1
is: Q9UIG8
is encoded by: hsa:28232
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR GGH 7DHFe
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
reversible: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_8ca81d7f_93a4_488e_b76c_e18a46f0ec33
initial concentration: NaN
name: SLC33A1
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:9197
is: SBO:0000252
is: O00400
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_7a6f1e73_c392_485c_9512_261beda4a3ca
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: B7Z428
has only substance units: false
is: SBO:0000252
name: GNE
is encoded by: hsa:10020
initial concentration: NaN

metaR NRPPHRtu
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000269
name: Norepinephrine uniport
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2702e1e1_128c_4bb2_8d73_bf9efdac8576
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4709
has only substance units: false
is: Q6IB80
boundary condition: true
initial amount: NaN
name: NDUFB3

http://identifiers.org/biomodels.db/MODEL1310110030#_61e92679_6414_48f3_9609_b690e2c586db
type: Species
initial concentration: NaN
name: _AI697028_1_e
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI697028
initial amount: NaN
is: SBO:0000252

metaM orn m
is: CHEBI:46912
initial amount: NaN
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00214
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d8374027_4327_4168_b8fb_2cbdc2ff7da4
name: PIGC
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q92535
is encoded by: hsa:5279
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_446fe838_3dee_43da_adb9_3ae9017c9954
initial amount: NaN
name: SLC25A18
constant: false
has only substance units: false
boundary condition: true
type: Species
is: Q9H1K4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:83733

http://identifiers.org/biomodels.db/MODEL1310110030#_7b2777ce_4aa8_4b4f_b86d_f2436e778e97
constant: false
type: Species
is encoded by: hsa:5153
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q7Z364
name: PDE1B
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_19d70f2b_c870_44f6_8818_a84139e781a2
is encoded by: hsa:4722
type: Species
name: NDUFS3
is: O75489
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR PROt2r
is described by: ECO:0000304
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: L-proline reversible transport via proton symport
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110030#
reversible: true
is: SBO:0000185

metaM xol7aone m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
type: Species
is: HMDB01993
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899

metaR S6TASE22ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reversible: true
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reactant: MODEL1310110030#
fast: false

metaM 42A3HP24DB c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
is: http://identifiers.org/pubchem.compound/7956
constant: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: C05645
is: HMDB04083
type: Species

metaR TCHOLAtx
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110030#
is: SBO:0000185
fast: false
name: bile acid intracellular transport
reactant: MODEL1310110030#

metaM ipdp x
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
name: isopentenyl diphosphate(3-)
initial amount: NaN
is: HMDB01347
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_cc95e980_5813_4bd9_94c9_f60f0fab3e9c
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2589
initial amount: NaN
name: GALNT1
initial concentration: NaN
type: Species
constant: false
is: Q10472

metaR PPAm
reversible: false
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
kinetic law: MODEL1310110030#
name: inorganic diphosphatase
product: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaR IZPN
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
name: Imidazolonepropionase
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000176

metaR r0590
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
product: MODEL1310110030#
type: Reaction
fast: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000
is: SBO:0000176

metaR GLNtN1
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
name: Glutamine transport (Na, H coupled)
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
is: SBO:0000185
type: Reaction

metaM fe3 c
constant: false
name: Fe3+
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB12943
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3
boundary condition: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_eb831be9_1747_468e_90b6_4f58c0d9ed81
initial concentration: NaN
is: O75874
constant: false
has only substance units: false
initial amount: NaN
name: IDH1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3417
type: Species

metaR PEAMNO
fast: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: Phenethylamine oxidase

http://identifiers.org/biomodels.db/MODEL1310110030#_056ff9c2_fddd_42d4_b597_88501abfa7e7
is encoded by: hsa:10246
name: SLC17A2
constant: false
is: O00624
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM 4hbz m
has only substance units: false
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
name: 4-hydroxybenzoate
initial amount: NaN
is: CHEBI:17879
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00500

http://identifiers.org/biomodels.db/MODEL1310110030#_db42fac9_2ff8_4da4_a8b3_151bd495bf53
name: ACAA1
is: Q96CA6
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:30
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM lac L x
initial concentration: 1.0
boundary condition: false
is: CHEBI:16651
constant: false
initial amount: NaN
is: SBO:0000247
name: (S)-lactate
type: Species
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190

metaM thcholstoic m
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
is: HMDB03873

http://identifiers.org/biomodels.db/MODEL1310110030#_65810b56_7691_46dc_a526_a73fd1a4366f
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: ECHS1
is: P30084
is encoded by: hsa:1892
has only substance units: false

metaM glx x
constant: false
has only substance units: false
is: CHEBI:36655
is: HMDB00119
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

metaM glc D c
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00122
constant: false
is: CHEBI:4167
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

http://identifiers.org/biomodels.db/MODEL1310110030#_83407f44_8f75_414c_8bb9_9691c12fd4a3
is encoded by: hsa:2572
boundary condition: true
name: GAD2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: Q5VZ30
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_d5ae9c19_6469_4044_9ec3_56a3c1cc09be
type: Species
is encoded by: hsa:93183
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q9H3S5
is encoded by: hsa:54965
initial amount: NaN
constant: false
boundary condition: true
has part: Q8TBF5
name: PIGX:PIGM

metaR RE1533M
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
reversible: true
name: RE1533
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR MALT
is described by: ECO:0000269
reactant: MODEL1310110030#
fast: false
name: alpha-glucosidase
kinetic law: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM sphings l
has only substance units: false
constant: false
name: sphingosine(1+)
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57756
is: HMDB00252
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_3479e4c2_4815_43a6_a11d_635b89358c8e
name: INPP5D
is: Q92835
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3635
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM lac L e
name: (S)-lactate
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190
initial amount: NaN
is: SBO:0000247

metaM galside hs c
initial amount: NaN
constant: false
is: CHEBI:12947
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

metaM ksi pre32 g
initial amount: NaN
constant: false
is: CHEBI:28067
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 32
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_bdd0edd9_a7b7_473b_a140_493cc610b9f5
name: ACSL6
is: SBO:0000252
is encoded by: hsa:23305
initial concentration: NaN
boundary condition: true
is: B2RB13
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM 56dura c
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00076
constant: false
is: CHEBI:15901
type: Species
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429

metaM coucoa m
has only substance units: false
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
initial concentration: 1.0
initial amount: NaN
name: 4-coumaroyl-CoA(4-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57355
constant: false
type: Species
is: C00223

metaR HMGLx
fast: false
name: hydroxymethylglutaryl-CoA lyase
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000134
modifier: MODEL1310110030#
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#

metaM hs deg17 l
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
name: heparan sulfate, degradation product 17
type: Species
is: SBO:0000247
is: CHEBI:21338
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02704
constant: false
boundary condition: false

metaR r1030
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
reversible: true

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: CHEBI:29034
initial concentration: 1.0
name: Fe3+
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: HMDB12943
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e71b35f5_89f1_4352_bfa4_691b7817bcda
name: GLDC
boundary condition: true
is encoded by: hsa:2731
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P23378

metaR r0580
type: Reaction
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
modifier: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

metaR ASNSERNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
fast: false

metaR P45027A1m
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
is described by: ECO:0000269
name: Cytochrome P450 27
reactant: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_f609c2f4_8331_43ff_ad12_87d3bcbb3675
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:85365
boundary condition: true
name: ALG2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9H553

http://identifiers.org/biomodels.db/MODEL1310110030#_9beff81c_dd24_4015_9190_192bcaea37f2
boundary condition: true
is encoded by: hsa:116369
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q96RN1
type: Species
constant: false
has only substance units: false
name: SLC26A8

http://identifiers.org/biomodels.db/MODEL1310110030#_1eb0bd26_92e2_4edb_bde4_6192c174715f
boundary condition: true
is: P16260
has only substance units: false
initial amount: NaN
name: SLC25A16
is: SBO:0000252
is encoded by: hsa:8034
initial concentration: NaN
type: Species
constant: false

metaM ksi pre19 g
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 19
is: SBO:0000247
is: HMDB00175
constant: false
boundary condition: false
is: C00130
is: CHEBI:58053
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
has only substance units: false
type: Species

metaR IDOAASE3ly
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110030#
reactant: MODEL1310110030#
name: alpha-L-iduronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
kinetic law: MODEL1310110030#
type: Reaction

metaM tsul c
is: SBO:0000247
initial amount: NaN
is: HMDB00257
name: thiosulfate(2-)
has only substance units: false
is: CHEBI:16094
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5f0fdca4_9808_413e_8f83_845c2abb79ac
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
name: CPT1B
type: Species
boundary condition: true
is: SBO:0000252
is: Q92523
initial amount: NaN
constant: false

metaR r0999
reversible: true
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110030#_96dd0871_7d73_424e_8c77_49e02d8699e8
initial amount: NaN
name: SDHB
initial concentration: NaN
is encoded by: hsa:6390
is: SBO:0000252
has only substance units: false
type: Species
is: P21912
boundary condition: true
constant: false

metaR PAPStg
name: 3'-Phosphoadenylyl sufate Golgi transport
fast: false
reversible: true
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_e96e9575_2d3b_4671_af97_dd85624ae30d
has only substance units: false
is encoded by: hsa:5140
initial concentration: NaN
constant: false
type: Species
is: A7E2E5
name: PDE3B
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_9bb9a737_d926_4a07_8d16_0e2feafc2bdb
name: SLC20A1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6574
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q8WUM9
initial concentration: NaN

metaM lac L c
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: CHEBI:16651
is: HMDB00190
boundary condition: false
initial amount: NaN
name: (S)-lactate

metaR DNDPt26m
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: dCDP transport via dUDP antiport
reversible: false

metaR DM dttp m
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaR ENGASE3ly
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal

metaR FALDH
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
name: formaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_b2a150fb_160a_46fc_8021_b332beeca714
constant: false
boundary condition: true
name: SLC25A1
is: SBO:0000252
is: D9HTE9
has only substance units: false
is encoded by: hsa:6576
initial concentration: NaN
initial amount: NaN
type: Species

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaR 1PPDCRp
kinetic law: MODEL1310110030#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM ksii core2 pre5 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
is: HMDB00175
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
is: C00130
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5

metaR CEPTC
type: Reaction
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000176
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.8.2
is described by: ECO:0000269
modifier: MODEL1310110030#
name: choline phosphotransferase
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaR MANt1r
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reactant: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000185
name: mannose transport (uniport)

metaR G14T4g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_e9d55cfb_e60b_4a16_8a0d_43522e09bd90
is: Q709F0
is encoded by: hsa:84129
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ACAD11
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM icit m
initial amount: NaN
boundary condition: false
name: Isocitrate
is: CHEBI:16087
is: SBO:0000247
is: C00311
initial concentration: 1.0
constant: false
is: HMDB00193
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species

metaR NH4tn
reactant: MODEL1310110030#
name: ammonia nuclear transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_706a42a5_4102_4cda_b4da_814f33691d2e
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8818
type: Species
name: DPM2
initial amount: NaN

metaR FACOAL160i
modifier: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
name: C160 fatty acid activation
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9e518153_f31a_4233_ac27_a4409309f913
is: B4DXZ1
is encoded by: hsa:440
name: ASNS
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_1d315d82_3022_4975_94be_e6cbd81d0c04
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4712
is: SBO:0000252
is: Q5VYT2
name: NDUFB6
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaM occoa x
boundary condition: false
constant: false
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: SBO:0000247
is: CHEBI:57386
initial amount: NaN
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
initial concentration: 1.0

metaR ACOAD1fm
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is: SBO:0000176

metaM C05279 m
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: CHEBI:28387
initial amount: NaN
type: Species
boundary condition: false
is: HMDB11123
initial concentration: 1.0
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247

metaM dgchol x
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: glycochenodeoxycholate
initial concentration: 1.0
is: CHEBI:36252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a56813e7_ab99_41bf_bc73_7dd2bf25c9d1
is encoded by: hsa:AI620219
type: Species
is: SBO:0000252
name: _AI620219_1_c
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR DOPAt4 2 r
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110030#
name: Dopamine reversible transport in via sodium symport (1:2)
product: MODEL1310110030#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000185

metaM CE1944 c
initial amount: NaN
is: CHEBI:36781
boundary condition: false
name: 1-pyrrolinium
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944

metaM galside hs g
initial concentration: 1.0
constant: false
is: CHEBI:12947
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686

http://identifiers.org/biomodels.db/MODEL1310110030#_7f457b2c_4e7a_471a_be86_2a891bba8c46
name: CYP7A1
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P22680
is encoded by: hsa:1581

http://identifiers.org/biomodels.db/MODEL1310110030#_d360c745_6a3f_4ba0_93a2_120a08bfff8d
name: ATP2B4
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P23634
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:493

metaR NH4tp
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110030#
reactant: MODEL1310110030#
name: ammonia peroxisomal transport

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110030#
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110030#

metaM 2oxoadp c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: 2-oxoadipate(2-)
initial concentration: 1.0
type: Species
is: CHEBI:57499
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225

http://identifiers.org/biomodels.db/MODEL1310110030#_8822e449_855c_4d0e_b1c9_eedf144dd672
is: E9PCI1
initial concentration: NaN
is: SBO:0000252
name: ACP2
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:53

metaM gchola c
is: HMDB00138
name: glycocholate
is: SBO:0000247
constant: false
is: CHEBI:58235
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial amount: NaN
type: Species
has only substance units: false

metaR FAOXC161802m
modifier: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid

metaM met L c
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB00696
name: L-methionine
is: CHEBI:16643

metaR r0584
reversible: true
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM gt3 hs g
type: Species
initial amount: NaN
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
boundary condition: false
is: CHEBI:28424
initial concentration: 1.0
constant: false
name: GT3
is: SBO:0000247
has only substance units: false

metaR LEUKTRA4t
product: MODEL1310110030#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110030#
type: Reaction
name: leukotriene A4 transport
reactant: MODEL1310110030#

metaR r0995
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110030#
reactant: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_56ec0a3d_5355_41c4_afb3_515413a84e86
initial amount: NaN
name: COX6A2
is: SBO:0000252
initial concentration: NaN
is: Q02221
is encoded by: hsa:1339
type: Species
constant: false
boundary condition: true
has only substance units: false

metaM ksi deg41 l
constant: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C34H58N2O26 CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:12936
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 41

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR AG13T5g
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110030#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110030#

metaM ctp n
is: SBO:0000247
is: CHEBI:37563
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
has only substance units: false
name: CTP(4-)
is: HMDB00082
boundary condition: false
initial amount: NaN
type: Species

metaR DGCHOLtx
reversible: true
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
name: bile acid intracellular transport
kinetic law: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000

metaR BALAtmr
fast: false
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
name: Beta-alanine reversible mitochondrial transport (diffusion)
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110030#_09277378_108a_4df7_be44_53cf4840a8f0
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: _W74642_1_c
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:W74642
type: Species

metaM gchola e
is: SBO:0000247
constant: false
has only substance units: false
name: glycocholate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0

metaR r0587
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction

metaR CSPG Etly
reversible: false
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
name: chondroitin sulfate E transport, extracellular to lysosome
is: SBO:0000185
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM g3m8mpdol L r
initial amount: NaN
type: Species
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: C00459
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37568
constant: false
is: HMDB01342

http://identifiers.org/biomodels.db/MODEL1310110030#_6f3d73fc_ec8f_4e33_a7bc_ec0f02a1ccfa
initial amount: NaN
is: SBO:0000252
is: Q308M7
name: ENPP3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5169
type: Species
boundary condition: true
constant: false

metaM sphings c
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: sphingosine(1+)
is: SBO:0000247
is: CHEBI:57756
is: HMDB00252
constant: false
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

metaR r1623
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9dd3e083_27f6_4d6e_8369_d4a443233ca6
is: SBO:0000252
type: Species
has only substance units: false
is: D3DNH0
boundary condition: true
is encoded by: hsa:2992
initial concentration: NaN
name: GYG1
constant: false
initial amount: NaN

metaM ksi deg26 l
initial amount: NaN
boundary condition: false
is: CHEBI:58343
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
name: keratan sulfate I, degradation product 26
has only substance units: false
is: HMDB00061
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_a78fc091_4a8b_4445_ad2a_c658620080f6
initial amount: NaN
is: SBO:0000252
name: CTH
boundary condition: true
is encoded by: hsa:1491
is: P32929
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR TDCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: bile acid intracellular transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
fast: false

metaR CDIPTr
name: phosphatidylinositol synthase (Homo sapiens)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110030#
reversible: true
fast: false
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.8.11

metaR r1965
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
product: MODEL1310110030#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110030#

metaR SUCCtp
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110030#
name: succinate transporter, peroxisome
kinetic law: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000

metaM ksi pre5 g
is: CHEBI:28067
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5
type: Species
notes: FORMULA: C101H164N7O75SX CHARGE: -2
has only substance units: false
initial concentration: 1.0

metaM retinol c
type: Species
is: CHEBI:50211
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
name: retinol
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00305

metaR r1622
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#

metaM glc D l
type: Species
initial amount: NaN
name: D-glucose
is: CHEBI:4167
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
boundary condition: false
is: HMDB00122

http://identifiers.org/biomodels.db/MODEL1310110030#_1f422fdb_1336_4f4a_9b56_0b38b30c1e93
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: _AI601100_1_m
is encoded by: hsa:AI601100
has only substance units: false

metaR r2405
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
product: MODEL1310110030#

metaR BILIRUBtr
name: lipid, flip-flop intracellular transport
is: SBO:0000185
product: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction

metaM HC02217 e
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
name: prostaglandin-g2
constant: false
is: CHEBI:27647
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM idp n
initial concentration: 1.0
initial amount: NaN
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
constant: false
is: SBO:0000247
type: Species
name: IDP(3-)
boundary condition: false
has only substance units: false

metaR THRGLNNaEx
modifier: MODEL1310110030#
is: SBO:0000185
type: Reaction
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#

metaR r1621
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110030#_00593532_a028_4b0c_84d4_cf4e2d2da165
name: COX7A2L
initial amount: NaN
is: Q6FGA0
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9167

metaM retfa c
boundary condition: false
name: fatty acid retinol
constant: false
type: Species
has only substance units: false
is: HMDB00305
is: CHEBI:50211
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN

metaM g1p c
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01586
type: Species
name: D-Glucose 1-phosphate
is: C00103
has only substance units: false
is: CHEBI:58601
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_24b6c794_f2a0_4b5a_9c7c_1ba6a51ede5f
initial amount: NaN
is: B3KXY9
boundary condition: true
has only substance units: false
is: SBO:0000252
name: HK1
constant: false
is encoded by: hsa:3098
initial concentration: NaN
type: Species

metaM tyr L m
is: CHEBI:17895
name: L-tyrosine
initial amount: NaN
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaM C02470 c
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5485
name: Xanthurenic acid
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: HMDB00881
is: SBO:0000247
is: C02470
boundary condition: false
type: Species
initial amount: NaN

metaR P45027A15m
modifier: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110030#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
reactant: MODEL1310110030#
product: MODEL1310110030#

metaR r1963
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000185

metaM man6p c
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
name: D-Mannose 6-phosphate
is: HMDB01078
initial concentration: 1.0
initial amount: NaN

metaR r1620
reversible: true
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaM met L e
initial amount: NaN
constant: false
is: HMDB00696
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
type: Species
name: L-methionine

metaR RE3524R
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reversible: true

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_b0e4cd0a_a02d_4f7c_a702_990d6d1578cc
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5136
initial concentration: NaN
name: PDE1A
is: SBO:0000252
type: Species
is: P54750

metaM dolp L c
initial amount: NaN
initial concentration: 1.0
constant: false
name: dolichyl phosphate(2-)
has only substance units: false
is: CHEBI:57683
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8feaf2e5_a0ec_47cf_964d_4742b1d1a38c
has only substance units: false
initial concentration: NaN
name: DPAGT1
boundary condition: true
constant: false
is: Q9H3H5
initial amount: NaN
is encoded by: hsa:1798
is: SBO:0000252
type: Species

metaR SRTNt6 2 r
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is described by: ECO:0000269
fast: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR RE1903R
fast: false
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
name: RE1903

metaR r2408
is: SBO:0000185
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
type: Reaction

metaR ABUTD
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Aminobutyraldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110030#_1a2e652e_dff9_4ff1_a629_4e6c56fd31f4
has only substance units: false
is encoded by: hsa:1103
initial concentration: NaN
type: Species
initial amount: NaN
name: CHAT
constant: false
is: SBO:0000252
boundary condition: true
is: P28329

http://identifiers.org/biomodels.db/MODEL1310110030#_564a6b2e_5e32_44ff_b4d3_0a23343e433a
is encoded by: hsa:9963
name: SLC23A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaM HC01408 m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
constant: false
boundary condition: false
is: CHEBI:27648
has only substance units: false
type: Species
name: 3-Oxohexanoyl-CoA

metaM gsn e
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16750
constant: false
is: HMDB00133
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
initial amount: NaN
has only substance units: false

metaR r2070
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
fast: false

metaM icit c
type: Species
is: HMDB00193
boundary condition: false
is: CHEBI:16087
initial concentration: 1.0
name: Isocitrate
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311

metaM gsn c
name: Guanosine
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: C00387
is: HMDB00133
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaM ptth m
initial amount: NaN
boundary condition: false
has only substance units: false
name: pantetheine
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
initial concentration: 1.0
is: HMDB03426
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_63bc1dfe_a175_4d5a_9ac4_34f5523e8810
boundary condition: true
name: ALDH3A2
has only substance units: false
is encoded by: hsa:224
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: P51648
is: SBO:0000252

metaR PROSTGE2t2
is: SBO:0000185
reversible: true
name: prostaglandin uniport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
fast: false
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaM C02470 e
boundary condition: false
has only substance units: false
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
is: HMDB00881
is: C02470
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_71cd0e3e_09cf_44f6_ac08_19ed2b11e6c5
boundary condition: true
name: PIGB
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: Q92521
is encoded by: hsa:9488
constant: false

metaR DOLGPP Ler
reversible: false
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
fast: false
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#

metaM g3m8masn r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C05873
boundary condition: false
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
is: SBO:0000247
constant: false

metaM CE5120 m
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: HMDB00127
initial concentration: 1.0
boundary condition: false

metaR DNDPt3m
name: dATP transport via dCDP antiport
fast: false
product: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110030#
type: Reaction

metaM CE2434 m
is: C01936
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_9e469062_54d4_4da8_a310_cb6c9190e01a
boundary condition: true
constant: false
initial amount: NaN
is: Q8TET4
is encoded by: hsa:2595
name: GANC
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_6a662aea_0512_4690_8378_9c3810ebde37
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6482
name: ST3GAL1
constant: false
is: Q11201
initial amount: NaN
has only substance units: false

metaM 2oxoadp m
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00225
is: CHEBI:57499
initial amount: NaN
constant: false
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial concentration: 1.0

metaM ksii core2 pre6 g
constant: false
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C61H98N5O46SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110030#_6eec00e6_2a8c_496e_a360_da50a17c4050
boundary condition: true
is: P05091
is encoded by: hsa:217
name: ALDH2
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_85a24632_449c_4e23_a1ac_6b753925bf75
is encoded by: hsa:5321
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: P47712
initial concentration: NaN
type: Species
name: PLA2G4A
is: SBO:0000252

metaR PMANM
product: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
name: phosphomannomutase
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110030#

metaM 6a2ohxnt x
initial amount: NaN
boundary condition: false
name: 6-amino-2-oxohexanoic acid
initial concentration: 1.0
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
constant: false
is: HMDB12151
type: Species
is: SBO:0000247
is: CHEBI:17534
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_0dc12f29_6aed_4db5_88ea_0d43bf59e1c0
is encoded by: hsa:3945
name: LDHA:LDHB
is: SBO:0000297
has only substance units: false
initial amount: NaN
has part: P00338
initial concentration: NaN
type: Species
is encoded by: hsa:3939
constant: false
boundary condition: true
has part: P07195

metaR S6TASE23ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_53b8b1a9_1a32_4cb8_bf80_37764c29fa91
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: B7Z1R0
has only substance units: false
name: SLC4A10
initial concentration: NaN
is encoded by: hsa:57282

http://identifiers.org/biomodels.db/MODEL1310110030#_f63fce76_2b38_4e2e_a20d_f610ef21fd09
boundary condition: true
initial amount: NaN
constant: false
name: ST3GAL3
initial concentration: NaN
type: Species
is encoded by: hsa:6487
is: SBO:0000252
has only substance units: false

metaM glc D r
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
is: CHEBI:4167
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00122
has only substance units: false
name: D-glucose

metaM galgbside hs g
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
has only substance units: false
name: galactosylgloboside
initial amount: NaN
constant: false
is: CHEBI:18259

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269

metaR DNDPt15m
type: Reaction
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
name: dUDP transport via dGDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185

metaM HC02217 c
name: prostaglandin-g2
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:27647
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_548bbb03_df16_4419_992b_f567fd3e3479
type: Species
constant: false
is: P19367
initial amount: NaN
initial concentration: NaN
name: HK1
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_49b37fd4_ef55_46a2_a798_a04b62392692
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2629
initial amount: NaN
name: GBA
is: P04062
boundary condition: true
is: SBO:0000252

metaR BTNt2
name: Biotin reversible transport via proton symport
fast: false
is described by: ECO:0000269
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
type: Reaction
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8da36baf_b152_45c3_84bd_106aaaedc4bf
type: Species
is encoded by: hsa:1607
has only substance units: false
constant: false
name: DGKB
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r0706
reversible: false
reactant: MODEL1310110030#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.10
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction

metaR 3SALACBOXL
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#
reversible: false
name: 3-Sulfino-L-alanine carboxy-lyase
kinetic law: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.29

metaR r2089
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM forglu c
name: N-Formimidoyl-L-glutamate
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: SBO:0000247
is: HMDB00854
is: CHEBI:18327
constant: false
is: C00439

metaM 3aib D e
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
boundary condition: false
is: HMDB02299
is: SBO:0000247
constant: false
type: Species
is: C03265
name: D-3-Amino-isobutanoate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_ff984059_849e_447b_9989_db905f47bc43
initial concentration: NaN
has only substance units: false
name: _BG035985_1_c
type: Species
initial amount: NaN
is encoded by: hsa:BG035985
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_13fe175c_e4f1_409a_8e74_aa6e55b6d1ac
is encoded by: hsa:54981
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q9NWW6
is: SBO:0000252
initial amount: NaN
name: NMRK1

metaR RE1521M
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
name: RE1521
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r0249
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false

metaR RE0688E
modifier: MODEL1310110030#
fast: false
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110030#
name: RE0688
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_54dc62dd_48b2_4779_9d9a_cf8096fa1a11
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: Q96Q11
name: TRNT1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51095
has only substance units: false

metaR OCDCAtr
reactant: MODEL1310110030#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#

metaM ribflv c
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:3554
initial amount: NaN
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: C00255
constant: false
has only substance units: false
is: HMDB00244
name: Riboflavin

metaM fe2 e
boundary condition: false
initial concentration: 1.0
is: HMDB00692
initial amount: NaN
name: Fe2+
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
has only substance units: false
type: Species
is: CHEBI:29033
is: SBO:0000247

metaR r2088
reversible: true
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
type: Reaction

metaM m5mpdol L r
type: Species
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
has only substance units: false
is: CHEBI:37634
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR NACHEX21ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110030#
reversible: false
name: beta-galactosidase, lysosomal
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR S6T5g
reversible: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM 3aib D c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
boundary condition: false
initial amount: NaN
is: HMDB02299
is: SBO:0000247
name: D-3-Amino-isobutanoate
type: Species
is: C03265
constant: false
initial concentration: 1.0
has only substance units: false

metaR CMPSASn
is described by: ECO:0000304
fast: false
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: CMP sialic acid synthase, nuclear

metaR r2087
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185

metaM ribflv e
initial amount: NaN
has only substance units: false
is: C00255
is: SBO:0000247
is: CHEBI:3554
boundary condition: false
type: Species
name: Riboflavin
initial concentration: 1.0
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244

metaM hs deg11 l
boundary condition: false
has only substance units: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
initial concentration: 1.0
is: CHEBI:57737
constant: false
is: SBO:0000247
is: HMDB00868
type: Species
name: heparan sulfate, degradation product 11
initial amount: NaN

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ba4f9672_c40e_4bb5_809b_5b19d0cb94e0
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: CHST1
is encoded by: hsa:8534
boundary condition: true
initial concentration: NaN
is: O43916
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f0dce1f8_5eff_452c_a242_aca7fd45a34e
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1593
initial amount: NaN
is: Q02318
is: SBO:0000252
has only substance units: false
name: CYP27A1

metaR r0853
fast: false
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:

metaR NDPK10n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is described by: ECO:0000304
modifier: MODEL1310110030#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM ksi deg4 l
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
has only substance units: false
type: Species
is: CHEBI:57737
boundary condition: false
is: HMDB00868
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 4
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_4e7ba8f3_2c8e_465e_8d4b_f5cea355f4e6
constant: false
name: ECI1
is encoded by: hsa:1632
initial concentration: NaN
is: P42126
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR GLNCYSNaEx
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
name: L-cysteine/L-glutamine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_6e87fec1_ac84_4b74_8248_b5256f0b9164
has only substance units: false
is: SBO:0000252
name: PLCG2
constant: false
type: Species
is: P16885
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5336
boundary condition: true

metaR r2086
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_76361b7d_e737_411f_8604_0405d77b1ae2
is: SBO:0000252
is: Q8TE04
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:53354
name: PANK1
initial concentration: NaN
has only substance units: false

metaM fe2 c
is: SBO:0000247
name: Fe2+
is: HMDB00692
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false
constant: false
is: C00023
type: Species
is: CHEBI:29033
boundary condition: false
initial concentration: 1.0

metaR FTCD
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
type: Reaction
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: false
is: SBO:0000176
name: formimidoyltransferase cyclodeaminase

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_e6f8a625_7e4b_4450_8736_617c18576ac1
is encoded by: hsa:8802
boundary condition: true
name: SUCLG1
initial concentration: NaN
is: P53597
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM hco3 c
is: C00288
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Bicarbonate
constant: false
type: Species
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595

metaM xolest2 hs e
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:17002
name: cholesterol ester
initial concentration: 1.0
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_0c8aba15_5f31_49dd_b6a3_23369d58e6aa
initial concentration: NaN
is encoded by: hsa:29922
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NME7
has only substance units: false

metaR HSAT4ly
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_440dc42a_7946_40ae_8d2a_11e0ee11f214
initial amount: NaN
is: SBO:0000252
is: P00450
name: CP
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1356

metaM gal c
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C00124
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
is: SBO:0000247
initial amount: NaN
is: HMDB00143
name: D-Galactose

metaR IMPC
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110030#
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
name: IMP cyclohydrolase
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_a09f6a7e_f744_4c91_ae09_30aa46ef661e
initial concentration: NaN
initial amount: NaN
is: O43286
constant: false
is: SBO:0000252
is encoded by: hsa:9334
boundary condition: true
type: Species
has only substance units: false
name: B4GALT5

http://identifiers.org/biomodels.db/MODEL1310110030#_8182bd1b_49c5_4be9_b9c6_dd4c7cd116a8
type: Species
constant: false
initial concentration: NaN
is: Q8TDQ7
boundary condition: true
initial amount: NaN
is encoded by: hsa:132789
is: SBO:0000252
name: GNPDA2
has only substance units: false

metaR r1636
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0de470ab_a35d_4339_a283_ba1f54493531
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC4A5
type: Species
is encoded by: hsa:57835
initial concentration: NaN
is: Q9BY07

metaM occoa m
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
type: Species
is: CHEBI:57386
is: HMDB01070
is: SBO:0000247
is: C01944
boundary condition: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7673adc8_b403_4d72_9203_bf990f995d42
name: FUT8
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2530
is: SBO:0000252
initial concentration: NaN
is: Q546E0
type: Species
has only substance units: false

metaR r1637
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4373d0fd_a84b_4cb7_83ec_620ae9b44599
type: Species
is encoded by: hsa:8836
name: GGH
is: Q92820
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_3415b84c_fbdc_4f60_9fb9_0703af87cf71
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10195
constant: false
has only substance units: false
type: Species
name: ALG3
boundary condition: true
initial amount: NaN

metaR SERGLNexR
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glutamine reversible exchange
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR G12MT1 L
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110030#_9a615c9c_8f0d_4d94_bde6_4d90f21f08d1
name: ATP5J2
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6IBB3
has only substance units: false
is encoded by: hsa:9551
boundary condition: true

metaR HDDACBP
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM 2mop m
is: HMDB01172
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
initial amount: NaN
constant: false
is: CHEBI:57700
has only substance units: false
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
is: SBO:0000247

metaR DOLPMT4 Ler
type: Reaction
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_4d16eb19_6e4c_4fd9_b811_90ac7c7adce8
name: COX7B
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: P24311
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1349

metaM gal e
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
name: D-Galactose
is: HMDB00143
is: CHEBI:0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: C00124

metaR r1638
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_079f7993_8931_425d_8bc4_46f79fe547f1
constant: false
type: Species
name: _AI373818_1_m
is encoded by: hsa:AI373818
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r1377
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110030#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110030#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is described by: ECO:0000000

metaR NADNe
type: Reaction
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.2.5
product: MODEL1310110030#
is: SBO:0000176
fast: false
name: NAD nucleosidase,extracellular
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110030#

metaM o2s m
is: HMDB02168
is: SBO:0000247
is: C00704
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Superoxide anion
constant: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: CHEBI:18421

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_30e1f3ee_4dc8_4042_83ca_44256994f5f5
is: SBO:0000252
initial concentration: NaN
is: P07864
initial amount: NaN
constant: false
name: LDHC
boundary condition: true
has only substance units: false
is encoded by: hsa:3948
type: Species

metaR GALASE15ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110030#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
reversible: false

metaR IMPD
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.205
kinetic law: MODEL1310110030#
reversible: false
fast: false
name: IMP dehydrogenase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
is described by: ECO:0000134
modifier: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_22b66326_fc2e_49e8_9441_ef2773c0fc3b
has only substance units: false
type: Species
name: AGL
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:178
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a18c9044_db3e_4474_852c_be857ed9aaa8
is encoded by: hsa:10007
type: Species
constant: false
is: SBO:0000252
name: GNPDA1
has only substance units: false
boundary condition: true
initial amount: NaN
is: P46926
initial concentration: NaN

metaM zymstnl r
is: SBO:0000247
is: HMDB06841
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16608

metaR TRDR
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
fast: false
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
modifier: MODEL1310110030#
is: SBO:0000176

metaM CE5787 e
is: SBO:0000247
notes: FORMULA: C15H31N6O4 CHARGE: 1 INCHI: InChI=1/C15H30N6O4/c1-4-8(2)11(16)13(23)20-9(3)12(22)21-10(14(24)25)6-5-7-19-15(17)18/h8-11H,4-7,16H2,1-3H3,(H,20,23)(H,21,22)(H,24,25)(H4,17,18,19)/p+1/t8-,9+,10-,11-/m1/s1 EHMN_ABBREVIATION: CE5787
type: Species
initial amount: NaN
is: CHEBI:27485
has only substance units: false
name: kinetensin 1-3
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02710

metaR S6T13g
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
fast: false
is described by: ECO:0000000

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1378
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9a0c60a9_d766_4015_8b6a_d29c8d77efcf
initial amount: NaN
has only substance units: false
is encoded by: hsa:55753
name: OGDHL
is: Q9ULD0
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaR BTNt4i
modifier: MODEL1310110030#
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
name: Biotin uptake (antiport)
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_258e4ab5_34d7_4252_bfac_30dd37f78b8c
has only substance units: false
is encoded by: hsa:BE042354
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: _BE042354_1_m

metaR r1527
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#

metaM 13dpg c
initial amount: NaN
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01270
name: 3-Phospho-D-glyceroyl phosphate
constant: false
is: http://identifiers.org/pubchem.compound/3535
boundary condition: false
is: C00236
is: CHEBI:57604

http://identifiers.org/biomodels.db/MODEL1310110030#_6b6d4d89_7532_4cf1_a505_a0c5318b1649
is: SBO:0000252
type: Species
is encoded by: hsa:7372
initial concentration: NaN
constant: false
boundary condition: true
is: A8K5J1
initial amount: NaN
has only substance units: false
name: UMPS

metaM galside hs l
is: CHEBI:12947
is: SBO:0000247
has only substance units: false
constant: false
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
boundary condition: false

metaR FAOXC16080m
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: HMDB00143
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 9
initial amount: NaN
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaM HC00900 c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Methylmalonate
constant: false
is: CHEBI:30860
type: Species
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_b5bdaa27_7a26_42f7_ae5d_8ee394c5df77
initial concentration: NaN
is: SBO:0000252
is: Q9HC21
initial amount: NaN
is encoded by: hsa:60386
has only substance units: false
type: Species
name: SLC25A19
boundary condition: true
constant: false

metaR ACACT1rm
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110030#
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR r1262
reversible: false
kinetic law: MODEL1310110030#
is: SBO:0000176
name: EC:6.2.1.3
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
is: C03265
constant: false
initial concentration: 1.0
name: D-3-Amino-isobutanoate
boundary condition: false
is: SBO:0000247
is: HMDB02299
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_03e7f5da_e6a3_4088_9b9a_3a5cd4a57c01
is: Q16851
is encoded by: hsa:7360
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: UGP2
type: Species
boundary condition: true

metaR SARDHm
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
name: Sarcosine dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.5.99.1

metaR GALSIDEtg
name: galactocerebroside intracellular transport
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_730b4413_8c54_4c52_be21_a63a8b6b968d
initial amount: NaN
name: CA7
is: P43166
type: Species
is encoded by: hsa:766
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaM thcrm hs g
is: SBO:0000247
is: CHEBI:24636
constant: false
type: Species
name: trihexosyl ceramide
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

metaR RE2625M
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE2625
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#

metaM ksi deg37 l
notes: FORMULA: C62H104N4O46 CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 37
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953
is: SBO:0000247
type: Species
is: HMDB00812

metaM ha pre1 l
is: CHEBI:16126
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
has only substance units: false
constant: false
name: hyaluronan biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110030#_982ef537_e4b0_460d_b070_9e35bc379f42
is: O00483
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4697
name: NDUFA4
initial amount: NaN

metaM icit x
initial concentration: 1.0
is: CHEBI:16087
constant: false
name: isocitrate(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00193

metaR RE3624M
kinetic law: MODEL1310110030#
type: Reaction
name: RE3624
reactant: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110030#
fast: false

metaR AG13T16g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
product: MODEL1310110030#
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#

metaR ITCOALm
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
product: MODEL1310110030#
fast: false
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110030#
type: Reaction

metaM pail4p hs c
initial amount: NaN
is: CHEBI:58178
constant: false
boundary condition: false
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
initial concentration: 1.0

metaM ctp c
boundary condition: false
initial amount: NaN
is: HMDB00082
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP
is: C00063
is: SBO:0000247
is: CHEBI:37563

metaR r1260
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
fast: false
is: SBO:0000176
name: EC:6.2.1.3
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#

metaR DTTPtn
product: MODEL1310110030#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_213516a5_7762_49cf_ba37_1090b7b3a460
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2348
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: FOLR1

metaR r0242
reactant: MODEL1310110030#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_834504b0_3a4c_45d3_8568_79917f4786d2
is: SBO:0000252
is: Q96JQ3
name: CSAD
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51380
type: Species
constant: false
boundary condition: true

metaM ksi pre4 g
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: C00130
initial amount: NaN
has only substance units: false
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 4
is: SBO:0000247
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_8bbd0905_86de_4856_84a2_cd1c0b226d5a
type: Species
constant: false
initial concentration: NaN
is: P51178
initial amount: NaN
name: PLCD1
boundary condition: true
has only substance units: false
is encoded by: hsa:5333
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_d6605a72_da84_4901_861b_2d20c33cf105
name: NDUFB8
is encoded by: hsa:4714
initial amount: NaN
boundary condition: true
is: O95169
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR HRETNtn
reversible: true
is described by: ECO:0000000
fast: false
name: 4-hydroxyretinoic acid transport, Nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM cholcoa c
initial concentration: 1.0
is: SBO:0000247
name: choloyl-CoA(4-)
is: HMDB01374
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

http://identifiers.org/biomodels.db/MODEL1310110030#_413cc1d4_d34d_4c8b_ba00_6b6be36b3fac
is: Q06830
boundary condition: true
is encoded by: hsa:5052
initial amount: NaN
is: SBO:0000252
constant: false
name: PRDX1
type: Species
initial concentration: NaN
has only substance units: false

metaR SUCOASm
name: Succinate--CoA ligase (ADP-forming)
kinetic law: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110030#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR G14T17g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110030#_5e6bc4c6_01b4_4dbb_925a_2fca4d828f29
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: _R33828_1_c
is encoded by: hsa:R33828
type: Species

metaR DM anth
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7ae8af1e_df22_4e64_99fa_9498b83a932b
is encoded by: hsa:64077
is: Q9H008
initial concentration: NaN
name: LHPP
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_140c02a2_69c2_400d_be88_ca1abe15ddc2
constant: false
initial concentration: NaN
name: DGKZ
is: B7Z2M9
is encoded by: hsa:8525
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR r0245
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

metaR GALSIDEtl
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: galactocerebroside intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110030#
type: Reaction

metaM o2s c
is: SBO:0000247
name: superoxide
constant: false
is: HMDB02168
has only substance units: false
is: CHEBI:18421
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false

metaR 13DAMPPOX
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.22
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
is described by: ECO:0000212
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR CSPG Btly
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110030#
name: chondroitin sulfate B transport, extracellular to lysosome
is: SBO:0000185
reversible: false
type: Reaction

metaR XOLDIOLONEt
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true

metaM ctp e
is: HMDB00082
type: Species
boundary condition: false
constant: false
name: CTP(4-)
has only substance units: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00472
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_64f99035_5c66_4059_8cd2_923fcd21d15c
is: SBO:0000252
is encoded by: hsa:223
name: ALDH9A1
initial concentration: NaN
is: P49189
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR MI145PP
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
reversible: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_7ba9ad1a_0cbf_4d96_ae90_50846499fe08
constant: false
is encoded by: hsa:11343
has only substance units: false
type: Species
initial concentration: NaN
name: MGLL
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: B2ZGL7

metaR r0139
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_39fff67b_68cc_435b_9d19_58db37283e78
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P51688
is encoded by: hsa:6448
initial concentration: NaN
type: Species
name: SGSH
constant: false
boundary condition: true

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_d60927e7_2193_459c_bcd9_1bf3a01296b4
is: B2RAT6
initial amount: NaN
type: Species
has only substance units: false
name: GALT
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:2592
is: SBO:0000252

metaR GPIDA2er
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
kinetic law: MODEL1310110030#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
modifier: MODEL1310110030#
reversible: false
is described by: ECO:0000000

metaM CE5586 c
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: CHEBI:58732
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

http://identifiers.org/biomodels.db/MODEL1310110030#_ccd7659c_781b_4e98_ba09_22763471a9d6
boundary condition: true
is: SBO:0000252
name: GGT2
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:728441
initial amount: NaN

metaR DASCBR
reactant: MODEL1310110030#
name: dehydroascorbate reductase
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/1.8.4.1
product: MODEL1310110030#
reversible: false
is: SBO:0000176
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000269

metaR MI1345PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176

metaM succ x
initial amount: NaN
is: SBO:0000247
type: Species
name: Succinate
has only substance units: false
initial concentration: 1.0
is: CHEBI:30031
is: C00042
is: HMDB00254
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR UGALNACtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
fast: false
name: UDP-GalNAc Golgi transport via CMP antiport
modifier: MODEL1310110030#
type: Reaction

metaM o2s e
constant: false
is: HMDB02168
name: superoxide
is: CHEBI:18421
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

http://identifiers.org/biomodels.db/MODEL1310110030#_f2c356c8_608a_4969_a287_518c1f73ec75
constant: false
is: SBO:0000252
name: SLC2A3
type: Species
is encoded by: hsa:6515
boundary condition: true
initial amount: NaN
has only substance units: false
is: P11169
initial concentration: NaN

metaM ha pre1 e
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110030#_d9e95bd0_2198_4a95_8e5d_1c8672bdca0b
is encoded by: hsa:10846
has only substance units: false
is: Q9Y233
name: PDE10A
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_de18eeef_6f9f_41fa_a149_a9a45c60a1fb
boundary condition: true
name: NT5C2
initial amount: NaN
has only substance units: false
is: P49902
type: Species
is encoded by: hsa:22978
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7dcc0add_bec5_4d63_b8bc_bc3986eba8c6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: ALPI
boundary condition: true
is: P09923
is encoded by: hsa:248

metaR r0246
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110030#
type: Reaction
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

metaR GMPR
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
is version of: http://identifiers.org/ec-code/1.7.1.7
type: Reaction
reversible: false
name: GMP reductase
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000269

metaR RE1532M
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110030#
name: RE1532
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_637ea4b6_53bb_4a4a_bb61_6e240ca2bab0
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:130
initial amount: NaN
constant: false
is: SBO:0000252
is: P28332
name: ADH6

metaM thbpt c
constant: false
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial amount: NaN
is: HMDB00027
type: Species
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
has only substance units: false
is: CHEBI:15372
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5037b706_e29c_41b2_aa39_99c18b9543f4
boundary condition: true
is encoded by: hsa:4711
constant: false
name: NDUFB5
initial concentration: NaN
is: O43674
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR UDPDOLPT L
is: SBO:0000176
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
product: MODEL1310110030#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
reactant: MODEL1310110030#

metaM ps hs m
boundary condition: false
constant: false
type: Species
name: ps_hs[m]
initial concentration: 1.0
is: CHEBI:18303
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: SBO:0000247

metaM ksii core2 deg2 l
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
boundary condition: false
is: HMDB00143
constant: false
initial amount: NaN
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 2

metaR ACt2r
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
name: acetate reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110030#_ed8982be_5216_47cc_ac52_fececf27614b
is: P51828
is encoded by: hsa:113
name: ADCY7
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r1380
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#

metaR ACCOAgt
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
name: acetyl-coa transport
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
fast: false
reversible: true

metaM fad e
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
initial concentration: 1.0
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
constant: false
initial amount: NaN
is: HMDB01248
is: CHEBI:16238

metaR r1493
fast: false
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
is: SBO:0000185
name: Utilized transport

metaM hs deg18 l
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: SBO:0000247
is: HMDB06254
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: heparan sulfate, degradation product 18
type: Species

metaR r1259
name: EC:6.2.1.3
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d1906414_be30_4b77_9581_b05becb61505
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:2544
name: _2544_1_c

http://identifiers.org/biomodels.db/MODEL1310110030#_ef41ad81_4c56_46b4_aed1_da1d6a437e57
has only substance units: false
initial amount: NaN
name: FOLR3
is: Q05C14
constant: false
is encoded by: hsa:2352
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM pail5p hs n
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57795
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaR r0570
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.3.2
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

metaM xoldiolone r
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB02197
is: CHEBI:28477
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false

metaR GALASE6ly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110030#
name: beta-galactosidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r1492
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
name: Utilized transport
fast: false
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000000
type: Reaction

metaM acetone c
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
name: acetone
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15347
boundary condition: false

metaM dsT antigen g
type: Species
is: CHEBI:16497
initial concentration: 1.0
constant: false
is: HMDB01440
has only substance units: false
boundary condition: false
is: SBO:0000247
name: disialyl-T antigen
notes: FORMULA: C36H56N3O26X CHARGE: -2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7bbf533e_1b8c_4591_b2fd_4e0b415f271d
initial amount: NaN
initial concentration: NaN
name: SLC26A6
is: Q9NQU1
type: Species
is encoded by: hsa:65010
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR IDOAASE4ly
name: alpha-L-iduronidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
reversible: false

metaR FAOXC141C141OHm
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_dd16ac9d_f6f3_4e09_95d5_d9ab07379765
boundary condition: true
name: _AI926493_1_c
is encoded by: hsa:AI926493
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_f352e7cb_bb53_4c2e_923a_9dad8a6d0fa0
is encoded by: hsa:79717
name: PPCS
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9HAB8
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_70ee6cff_b2c5_472f_bbc7_d75bed1a8c7e
is: Q02127
has only substance units: false
name: DHODH
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1723
is: SBO:0000252

metaR ARGt4
is: SBO:0000185
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
name: L-arginine transport in via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_6fd02b3a_9e46_41a8_a449_8b287a860856
is encoded by: hsa:4830
type: Species
boundary condition: true
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
name: NME1:NME2
has only substance units: false

metaM fad c
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01248
boundary condition: false
has only substance units: false
name: Flavin adenine dinucleotide oxidized
type: Species
is: CHEBI:16238
initial amount: NaN

metaR KSIt
type: Reaction
product: MODEL1310110030#
name: keratan sulfate I transport, golgi to extracellular
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR S3TASE2ly
reversible: true
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110030#
fast: false

metaM dc2coa m
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
is: CHEBI:61406
boundary condition: false
initial concentration: 1.0

metaR r1043
type: Reaction
reversible: false
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Concentrative Nucleoside Transporter (CNT) TCDB:2.A.41.2.3
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaM core2 g
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:15876
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: Core 2

metaR DMATTx
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
is: SBO:0000176
name: dimethylallyltranstransferase

http://identifiers.org/biomodels.db/MODEL1310110030#_75ccb8a4_9f03_4ef2_8689_0d7618ca9358
constant: false
is encoded by: hsa:952
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CD38
initial concentration: NaN
is: P28907

metaR r0688
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#

metaR P45039A1r
fast: false
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (51302.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - by analogy/similarity to xol hydrolase reactions (NADPH w/ O2 - NADH also noted to be cofactor if needed)
is version of: http://identifiers.org/ec-code/1.14.13.99
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
name: oxysterol 7-alpha-hydroxylase
reversible: false
is described by: ECO:0000269

metaM retinol cis 11 c
constant: false
name: 11-cis-retinol
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06216
is: CHEBI:16302
initial amount: NaN
is: SBO:0000247

metaR G14T3g
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110030#
reversible: false
fast: false
is: SBO:0000176

metaM acetone e
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: acetone
is: HMDB01659
constant: false
boundary condition: false
is: CHEBI:15347
is: SBO:0000247

metaR HSAT3ly
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaR URIDK2m
product: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: uridylate kinase (dUMP), mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_c6aaff62_6876_46f2_af45_a8275dd8fc3b
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: ALDH3B2
is: SBO:0000252
is: P48448
is encoded by: hsa:222

http://identifiers.org/biomodels.db/MODEL1310110030#_c3d8b3c4_1e3e_4e7f_b9d5_589cf34b0a26
has only substance units: false
boundary condition: true
type: Species
name: ATP5J
is: SBO:0000252
is encoded by: hsa:522
constant: false
initial concentration: NaN
initial amount: NaN

metaR KSItly
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, extracellular to lysosome
product: MODEL1310110030#

metaR DURAD
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
is described by: ECO:0000269
name: dihydrouracil dehydrogenase (NADP)
reversible: true
is: SBO:0000176
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_66afba64_2fed_4b4f_96bd_5401b8d7b037
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM Rtotal2coa c
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00095
initial concentration: 1.0
initial amount: NaN
name: R total 2 coenzyme A
is: CHEBI:60377
is: C00055
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_99b6db7c_912c_415a_9a05_86b04c6116da
boundary condition: true
is encoded by: hsa:2686
initial amount: NaN
is: SBO:0000252
name: GGT7
is: A0PJJ9
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR GALt2 2
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110030#
name: D-galactose transport via proton symport
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
reversible: true

metaR r0686
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110030#
product: MODEL1310110030#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110030#
reversible: true

metaM dcacoa x
constant: false
type: Species
is: HMDB06404
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: SBO:0000247
boundary condition: false
is: CHEBI:61430
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)

metaM creat e
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
type: Species
is: CHEBI:16919
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: creatine
initial amount: NaN
constant: false
is: HMDB00064

metaM akg c
is: CHEBI:16810
is: SBO:0000247
initial amount: NaN
name: 2-Oxoglutarate
boundary condition: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
initial concentration: 1.0
is: C00026
is: HMDB00208
has only substance units: false

metaM gacpail hs c
initial amount: NaN
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
has only substance units: false
is: HMDB01127
constant: false
is: CHEBI:57955
type: Species
is: C01236
is: SBO:0000247
initial concentration: 1.0

metaM Lcyst c
is: HMDB02757
has only substance units: false
initial concentration: 1.0
is: CHEBI:58090
is: SBO:0000247
boundary condition: false
name: L-cysteate(1-)
initial amount: NaN
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_8c8e81aa_4adf_4bf7_aeb3_82928f467778
is: SBO:0000252
is: Q9NY64
type: Species
is encoded by: hsa:29988
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: SLC2A8
boundary condition: true
constant: false

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6

metaM adn e
is: CHEBI:16335
initial concentration: 1.0
type: Species
constant: false
is: C00212
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
boundary condition: false
initial amount: NaN
name: Adenosine
is: HMDB00050

metaR C204CPT2
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
name: arachidonic acid transport into the mitochondria
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110030#
type: Reaction

metaR HMGCOASim
is: SBO:0000176
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10

metaR DM gpi sig er
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_e4e8abfe_3ecd_41e2_8eba_ffdb27d75ae4
name: PDE9A
type: Species
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: Gamma-glutamyltransferase

metaR DURAD2
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrothymin dehydrogenase (NADP)
reversible: true
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000269
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM HC01496 m
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
name: 2-Amino-3-oxoadipate
has only substance units: false
initial amount: NaN
is: CHEBI:28095

metaR GUAt
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110030#
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

metaM cholcoa x
type: Species
is: CHEBI:57373
initial amount: NaN
has only substance units: false
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaR GALASE4ly
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM orn e
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: HMDB00214
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:0
is: C01602
initial concentration: 1.0
type: Species
boundary condition: false
name: Ornithine

metaM citr L c
constant: false
is: CHEBI:16349
type: Species
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
boundary condition: false
name: L-citrulline
is: HMDB00904
is: SBO:0000247
initial concentration: 1.0

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_108f659d_ca48_444d_833a_93f0407db08d
name: NOS1
initial concentration: NaN
has only substance units: false
is: B4DG68
is encoded by: hsa:4842
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_7c5e8059_3db3_41f1_bcb6_8cb0302dcdac
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: AK1
is encoded by: hsa:203
type: Species
is: P00568

metaM akg e
initial amount: NaN
is: CHEBI:16810
name: 2-oxoglutarate(2-)
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00208
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_aa38f24a_1156_4e9b_9c70_1f8c9703f8cc
is encoded by: hsa:220
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: P47895
is: SBO:0000252
initial amount: NaN
name: ALDH1A3

metaR AG13T4g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction
product: MODEL1310110030#

metaM creat c
initial amount: NaN
is: HMDB00064
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
constant: false
name: creatine
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR PEPCKm
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
name: Phosphoenolpyruvate carboxykinase (GTP)
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.32
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM adn c
is: HMDB00050
is: CHEBI:16335
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
constant: false
is: C00212
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Adenosine
initial concentration: 1.0

metaM 2obut c
is: C00109
is: HMDB00005
is: SBO:0000247
is: CHEBI:16763
initial amount: NaN
type: Species
name: 2-Oxobutanoate
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR r1633
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1106
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_7d53e7be_c83c_44f8_be34_cff46b07f84f
constant: false
boundary condition: true
is: Q67FW5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:146712
type: Species
is: SBO:0000252
initial amount: NaN
name: B3GNTL1

metaM fad m
boundary condition: false
constant: false
is: C00016
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
is: HMDB01248
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaM orn c
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
has only substance units: false
is: C01602
type: Species
is: HMDB00214
initial amount: NaN
is: CHEBI:0
is: SBO:0000247
name: Ornithine
boundary condition: false

metaR KSII CORE2tly
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR PI4PLC
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176

metaM ksi deg28 l
boundary condition: false
is: CHEBI:16953
initial amount: NaN
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
has only substance units: false
name: keratan sulfate I, degradation product 28
is: HMDB00812
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r2080
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110030#
type: Reaction

metaR F1Atg
reactant: MODEL1310110030#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
name: F1alpha transport (from golgi to lysosome)
product: MODEL1310110030#

metaM ksii core2 pre4 g
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: HMDB00175
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
is: C00130
initial amount: NaN
constant: false

metaM ps hs e
initial concentration: 1.0
has only substance units: false
is: CHEBI:18303
name: phosphatidylserine
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaM xol7ah2al c
type: Species
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
boundary condition: false
is: HMDB06894
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
is: CHEBI:27428
initial concentration: 1.0

metaM ipdp c
boundary condition: false
is: SBO:0000247
is: C00129
type: Species
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial amount: NaN
is: CHEBI:128769
has only substance units: false
name: Isopentenyl diphosphate
is: HMDB01347
initial concentration: 1.0
constant: false

metaR UDPACGALtl
name: udpacgal intracellular transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
reactant: MODEL1310110030#
fast: false
type: Reaction

metaR r1632
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00175
type: Species
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: C00130
constant: false
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false

metaR THRSERNaEx
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
fast: false

metaR r0683
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is: SBO:0000176
modifier: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8339f887_dc74_4693_a367_0d5641f43749
is encoded by: hsa:65985
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: AACS
is: Q86V21

http://identifiers.org/biomodels.db/MODEL1310110030#_92e155a1_4acf_483a_ba22_6b1e194405e4
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: E5KNH5
is encoded by: hsa:4723
type: Species
is: SBO:0000252
name: NDUFV1
has only substance units: false

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

metaR r2081
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR S6TASE21ly
fast: false
kinetic law: MODEL1310110030#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110030#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110030#

metaR r1635
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR r0575
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d182595b_1cdb_4019_9e8d_0cc648114cdb
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q9Y2Q0
is encoded by: hsa:10396
initial amount: NaN
name: ATP8A1
is: SBO:0000252

metaR r0680
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
reversible: true
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_68e99f1c_86ae_44b5_ad80_1f4df177cf76
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI090874
name: _AI090874_1_c
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_6494fc7c_4b5c_4c03_8923_bb2f028bddaf
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51205
is: SBO:0000252
name: ACP6
constant: false
is: Q9NPH0
type: Species

metaM Lfmkynr c
name: N-formyl-L-kynurenine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
is: CHEBI:30249
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01200

metaR ECOAH1m
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110030#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito

metaM CE1926 e
name: gama-carboxyethyl-hydroxychroman
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15748

metaM ps hs c
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
initial amount: NaN
name: ps_hs[c]
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaR r1634
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM gacpail hs r
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57955
name: glucosaminyl-acylphosphatidylinositol
is: C01236
constant: false
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01127

metaM acetone m
constant: false
is: CHEBI:15347
is: HMDB01659
name: acetone
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_63c0fafd_a495_40f1_93fd_f91ae3d996a9
is encoded by: hsa:124454
initial amount: NaN
is: Q5JPH6
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: EARS2

metaM dnad c
is: HMDB01179
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: SBO:0000247
is: C00857
type: Species
initial concentration: 1.0
is: CHEBI:18304
name: Deamino-NAD+
boundary condition: false

metaM ha deg1 l
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16336
name: hyaluronan degradation product 1
notes: FORMULA: C22H33N2O16 CHARGE: -1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_01765c6c_7d78_4d72_b0b5_3daa7ffbc178
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4598
is: B2RDU6
is: SBO:0000252
boundary condition: true
has only substance units: false
name: MVK

metaM 5aop m
has only substance units: false
boundary condition: false
constant: false
name: 5-Amino-4-oxopentanoate
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
initial concentration: 1.0
is: C00430
is: CHEBI:17549
is: HMDB01149
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_03dd9a52_f9b3_4382_ab25_0f0057443f9d
constant: false
name: AKR1C4
type: Species
is encoded by: hsa:1109
has only substance units: false
is: P17516
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR H2Ot
is: SBO:0000185
name: H2O transport via diffusion
is described by: ECO:0000269
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
type: Reaction
reversible: true

metaR r0142
type: Reaction
reversible: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#

metaR MHISOR
modifier: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110030#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_e34086b1_9e8e_4cd7_9ba3_6ab88b09b0e0
has only substance units: false
constant: false
is encoded by: hsa:124
is: SBO:0000252
initial amount: NaN
type: Species
name: ADH1A
initial concentration: NaN
is: P07327
boundary condition: true

metaR AKGMALtm
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110030#
name: alpha-ketoglutarate/malate transporter
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
reactant: MODEL1310110030#

metaR NACDe
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9c12a354_fb09_49cd_b02c_8d17871db4ba
is encoded by: hsa:10380
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: BPNT1
is: O95861

metaR r1956
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000

metaR DPHMBDCm
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000176
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation

metaR RE2626C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: RE2626
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
fast: false

metaR r1384
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0984693c_8feb_49d1_a958_0bee56792714
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9P1E4
is encoded by: hsa:4122
name: MAN2A2
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0d4b096d_85d5_4959_a6aa_df36c7315ea7
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q6AI14
is encoded by: hsa:389015
name: SLC9A4

metaR LEUPHELAT2tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r2084
reversible: true
is: SBO:0000185
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ACt2m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110030#
name: acetate mitochondrial transport via proton symport

metaR MMCDm
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
is version of: http://identifiers.org/ec-code/4.1.1.9
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: false
is described by: ECO:0000212
fast: false
reactant: MODEL1310110030#
type: Reaction
name: Methylmalonyl-CoA decarboxylase, mitochondrial

metaR MCLACCYSR
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: 3-mercaptolactate:cysteine reductase
reactant: MODEL1310110030#

metaM occoa c
is: C01944
type: Species
is: HMDB01070
boundary condition: false
has only substance units: false
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
initial concentration: 1.0

metaR r2419
product: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110030#

metaR IPDPtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
reversible: true
fast: false
product: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000134
kinetic law: MODEL1310110030#
type: Reaction
name: Isopentenyl diphosphate transport (peroxisome)

metaM 2mop c
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
type: Species
is: HMDB01172
is: CHEBI:57700
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_16e31037_079c_404b_a8a2_56e45b92bbc7
type: Species
name: PCBD2
is: Q9H0N5
is encoded by: hsa:84105
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM sphmyln hs c
boundary condition: false
is: HMDB02704
initial concentration: 1.0
name: sphmyln_hs[c]
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:21338
notes: FORMULA: CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d0701155_c5c6_4a1c_b657_c471c12375c8
initial concentration: NaN
has only substance units: false
constant: false
name: ST8SIA5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29906
type: Species
is: O15466
boundary condition: true

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
reversible: true
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR r2085
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR r0579
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.13.11.19
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110030#_942fee02_9c53_41d3_be9d_dc3b0987ae77
name: _R06874_1_r
is encoded by: hsa:R06874
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_5b7887c7_a645_4d29_98b6_ed4001a81eb0
boundary condition: true
initial amount: NaN
has only substance units: false
is: P43034
is encoded by: hsa:5048
is: SBO:0000252
constant: false
type: Species
name: PAFAH1B1
initial concentration: NaN

metaM gal l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
constant: false
is: CHEBI:12936
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
name: D-galactose

metaR r1631
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_86cb2f82_2546_446c_bc3a_690b748d9f43
name: SLC26A6
constant: false
is: Q9Y3Y1
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:65010
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM acnam c
is: SBO:0000247
boundary condition: false
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00230
name: N-acetylneuraminate
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_627b0740_5f0a_4d06_893d_f9e2765582c3
is encoded by: hsa:4126
is: O00462
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: MANBA
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f1cee83f_8142_4fc0_8d8d_7d155df029b0
is: SBO:0000252
is: P17568
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFB7
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4713

metaR r2082
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000

metaM pacald c
initial concentration: 1.0
constant: false
type: Species
is: HMDB06236
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16424
has only substance units: false
name: phenylacetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110030#_80bb6019_878f_46f9_b832_987405450e7c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79017
is: B8ZZR8
boundary condition: true
has only substance units: false
initial concentration: NaN
name: GGCT
type: Species
constant: false

metaM cs a deg5 l
type: Species
initial amount: NaN
constant: false
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: SBO:0000247
has only substance units: false

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
name: CO2 peroxisomal transport
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_edf62beb_c754_49de_9249_b8b58f1f1552
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: PLA2G3
is encoded by: hsa:50487
initial concentration: NaN
type: Species
is: Q9NZ20

metaM 3dphb m
initial concentration: 1.0
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06251
constant: false
name: 3-Decaprenyl-4-hydroxybenzoate
initial amount: NaN

metaR r1630
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_805e9479_800b_4336_8d5c_c8601fe54e19
is: SBO:0000252
initial amount: NaN
name: NME4
constant: false
is: O00746
initial concentration: NaN
is encoded by: hsa:4833
has only substance units: false
type: Species
boundary condition: true

metaR TCHOLAte
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR r1381
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110030#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110030#
fast: false

metaR r2083
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9b993c4d_128b_45d4_8c43_5676c47330da
initial amount: NaN
name: _LOC728997_1_c
is encoded by: hsa:LOC728997
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM mescoa m
type: Species
boundary condition: false
is: CHEBI:27969
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Mesaconyl-CoA
is: C06028
initial concentration: 1.0
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
constant: false
is: CHEBI:28259
is: HMDB01052
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_e39faf04_712e_467b_a310_7d406bd55b4a
is: P50443
is: SBO:0000252
is encoded by: hsa:1836
boundary condition: true
constant: false
initial concentration: NaN
name: SLC26A2
initial amount: NaN
has only substance units: false
type: Species

metaM sph1p e
is: CHEBI:57939
is: SBO:0000247
is: HMDB01383
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3a6f1dd7_6b16_4c26_9e24_322bb02d921a
constant: false
has only substance units: false
is encoded by: hsa:522
initial amount: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
has part: Q6NZ59
initial concentration: NaN
type: Species

metaM uri e
name: Uridine
is: HMDB00296
is: CHEBI:16704
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: C00299
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
initial amount: NaN

metaR r2537
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
name: Utilized transport
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR T4HCINNMFM
name: 4-hydroxycinnamate formation
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaR GLYCt
name: glycerol transport via channel
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_7e884bf5_9917_46af_84e0_19e21cb2178e
type: Species
initial concentration: NaN
boundary condition: true
name: LEFTY1
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10637
is: SBO:0000252
is: O75610

metaM acnacngalgbside hs e
is: HMDB00223
initial amount: NaN
name: disialyl galactosylgloboside
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: C00036
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r2110
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110030#
reversible: true
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#

metaR r0756
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.1
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110030#

metaR RPEc
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110030#
fast: false
name: ribulose 5-phosphate 3-epimerase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is described by: ECO:0000134

metaM hpdcacoa c
is: HMDB06497
boundary condition: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial amount: NaN
name: heptadecanoyl coa
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR NACHEX20ly
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110030#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaM duri c
name: Deoxyuridine
initial concentration: 1.0
type: Species
is: CHEBI:16450
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00526
is: HMDB00012
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaR AG13T8g
kinetic law: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is: SBO:0000176

metaR r0021
is described by: ECO:0000000
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
product: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
type: Reaction
is: SBO:0000176

metaR DOLPMT1 Ler
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#

metaM crm hs r
constant: false
is: CHEBI:52639
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR LPS4e
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
fast: false
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.1.4
is described by: ECO:0000000
is: SBO:0000176
name: phospholipase
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_ea38157c_bcbe_42e3_a064_a755b9ce75dc
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: O75355
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:956
name: ENTPD3

metaM fprica c
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: HMDB01439
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58467
has only substance units: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
constant: false
is: C04734
type: Species

metaR FAOXC140
is described by: ECO:0000269
kinetic law: MODEL1310110030#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
modifier: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM ksi deg13 l
constant: false
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 13
boundary condition: false
has only substance units: false
is: HMDB00812
is: CHEBI:16953
is: SBO:0000247
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
initial concentration: 1.0

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM m4masn g
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05881

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR G14T16g
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR RE3421R
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
name: RE3421
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
product: MODEL1310110030#
is described by: ECO:0000000

metaM ksi deg20 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 20
type: Species
boundary condition: false
constant: false
is: CHEBI:12936

metaR r2535
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_12a6887f_4a65_497f_8e80_7161cf211c88
name: SDR16C5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:195814
constant: false
initial amount: NaN
is: B3KT84
type: Species

metaR S6TASE10ly
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176

metaR P4508B13r
product: MODEL1310110030#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.13.95
name: sterol 12-alpha-hydroxylase (nadh)
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is described by: ECO:0000269

metaR 3DSPHR
type: Reaction
reactant: MODEL1310110030#
name: 3-Dehydrosphinganine reductase
modifier: MODEL1310110030#
is described by: ECO:0000269
fast: false
product: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.102
reversible: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110030#

metaM acnacngalgbside hs g
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: C00036
name: disialyl galactosylgloboside
boundary condition: false
is: CHEBI:3338
has only substance units: false
initial concentration: 1.0

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
is: HMDB01383
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_ca70da85_1c3a_46d5_8494_753830bf5688
is: Q308M7
is encoded by: hsa:5169
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: ENPP3
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_f826e5bc_4231_451a_9fa1_3794bdb3d6e6
is: P00439
name: PAH
is encoded by: hsa:5053
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0456
modifier: MODEL1310110030#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r1609
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185

metaM cs e deg2 l
initial concentration: 1.0
is: HMDB00812
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
is: CHEBI:16953

metaR NDP8
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reversible: false
is described by: ECO:0000269
name: nucleoside-diphosphatase (dUDP)
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.9

http://identifiers.org/biomodels.db/MODEL1310110030#_9145f799_c351_4200_a5f3_74f2589a4a73
type: Species
is: SBO:0000252
constant: false
name: GPX1
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2876

http://identifiers.org/biomodels.db/MODEL1310110030#_d643867b_87de_400e_9af8_8816b5f16229
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1798
name: DPAGT1

metaR ALATHRNaEx
reversible: false
is: SBO:0000185
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
initial amount: NaN
initial concentration: 1.0
name: Deoxyuridine
is: SBO:0000247
has only substance units: false
is: C00526
boundary condition: false
is: HMDB00012
constant: false
is: CHEBI:16450

metaR GLNALANaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110030#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)

metaR r1608
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
fast: false
type: Reaction
reactant: MODEL1310110030#
reversible: true

metaM ksi deg35 l
constant: false
name: keratan sulfate I, degradation product 35
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
type: Species
initial amount: NaN
is: HMDB00143
has only substance units: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial concentration: 1.0

metaM m8masn g
is: SBO:0000247
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
is: C05876
type: Species
has only substance units: false
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false

metaM crm hs l
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: N-acylsphingosine
has only substance units: false
is: CHEBI:52639
type: Species

metaM prostgd2 r
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: prostaglandin D2(1-)
is: SBO:0000247
is: CHEBI:57406
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false
boundary condition: false

metaR PE HStm
name: phosphatidylethanolamine scramblase
product: MODEL1310110030#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction

metaR r2113
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_ac0de5e0_21f5_43d4_8e00_1e33b138faf9
constant: false
is: A6NFM2
type: Species
boundary condition: true
initial amount: NaN
name: PYCR1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5831
has only substance units: false

metaM aicar e
initial concentration: 1.0
is: CHEBI:58475
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: C04677
constant: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9fc0cbba_87a7_4ba6_b9a6_70f191dbf3d8
type: Species
constant: false
has only substance units: false
is: P56181
is: SBO:0000252
name: NDUFV3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4731
initial amount: NaN

metaM ksii core2 pre10 g
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 10
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C81H130N6O64S2X CHARGE: -3

metaR R group phosphotase 1
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: R group phosphotase 1
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8d026d96_b5fb_440c_afff_44e407b1a5a2
name: PANK4
type: Species
is: SBO:0000252
boundary condition: true
is: Q9NVE7
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:55229
has only substance units: false

metaM didp n
initial concentration: 1.0
boundary condition: false
name: dIDP
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
constant: false
is: SBO:0000247
is: CHEBI:28823
has only substance units: false
type: Species
initial amount: NaN

metaM 5forthf c
type: Species
initial concentration: 1.0
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
name: 5-Formiminotetrahydrofolate
boundary condition: false
initial amount: NaN
is: C00664
is: CHEBI:57456
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01534

metaR AGPAT1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
fast: false
is: SBO:0000176
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
is version of: http://identifiers.org/ec-code/2.3.1.15

http://identifiers.org/biomodels.db/MODEL1310110030#_59b0acd5_955b_4efb_be42_427b0677ddad
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: ECH1
is encoded by: hsa:1891
initial amount: NaN
constant: false
initial concentration: NaN
is: Q13011

metaR r2114
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#

metaM ksii core4 g
is: HMDB01014
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate II (core 4-linked)
is: CHEBI:57255
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
constant: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR R group phosphotase 2
reversible: false
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: R group phosphotase 2

metaR r1836
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110030#_19800be6_53ba_4562_a5ed_ec248a222b55
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: SLC36A1
is: SBO:0000252
is: Q1LZ56
constant: false
is encoded by: hsa:206358
initial amount: NaN

metaR RE1531M
fast: false
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
name: RE1531

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR COQ7m
reversible: false
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000269
fast: false
name: Ubiquinone biosynthesis COQ7

metaM frdp r
initial concentration: 1.0
is: CHEBI:175763
name: Farnesyl diphosphate
constant: false
initial amount: NaN
type: Species
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: C00448
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9e3bb896_f321_4889_9fd1_7ab5e184e4ee
type: Species
has only substance units: false
name: PANK3
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:79646
is: SBO:0000252
is: Q9H999

metaR r2111
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110030#

metaR r0757
reversible: true
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#

metaM acnacngalgbside hs c
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
is: C00036
boundary condition: false
has only substance units: false
is: HMDB00223
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:3338
name: disialyl galactosylgloboside

metaM udpglcur r
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00935
is: CHEBI:58052
has only substance units: false
name: UDP-D-glucuronate
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR r1835
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110030#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#

metaM aicar c
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false
is: HMDB01517
is: SBO:0000247
is: C04677
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_95a4a924_d510_43b8_914d_af8897c0b126
is: Q9BVK2
type: Species
is encoded by: hsa:79053
is: SBO:0000252
constant: false
name: ALG8
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM hs deg24 l
is: CHEBI:16126
name: GlcNAc-GlcA-(Gal)2-Xyl
notes: FORMULA: C31H50NO26 CHARGE: -1
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR TMDPP
name: thymidine phosphorylase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
modifier: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.4
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_4fa6bc1f_6a95_4df6_8952_801725ed9c0f
name: MAOA
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4128
has only substance units: false
initial amount: NaN
is: Q53YE7
constant: false

metaR 3MLDAt
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000
fast: false
name: 3MLDA extracellular transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
reactant: MODEL1310110030#
is: SBO:0000185

metaR r2112
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_64fdc41d_7ca5_49f6_aa3e_3a963c39f8d9
is: O15254
name: ACOX3
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8310
initial amount: NaN
boundary condition: true

metaM bilglcur r
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
has only substance units: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)

metaR HCO3 CLt
reactant: MODEL1310110030#
is described by: ECO:0000269
name: bicarbonate transport (Cl-/HCO3- exchange)
is: SBO:0000185
fast: false
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_7cb4b746_851c_42a1_a0e4_3c20891be7ee
constant: false
is: P18545
is encoded by: hsa:5148
type: Species
is: SBO:0000252
has only substance units: false
name: PDE6G
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR UGT1A10r
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.17
is described by: ECO:0000134
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_97733739_b1b5_4ca6_a910_dd124086ba7a
initial amount: NaN
name: PIGQ
has only substance units: false
is encoded by: hsa:9091
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: B2RAU6

http://identifiers.org/biomodels.db/MODEL1310110030#_47b5bfcf_359f_44f1_a845_763da50d55af
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ACOX1
is: B4DK61
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51

metaM ksii core4 e
type: Species
initial amount: NaN
is: HMDB00211
has only substance units: false
is: CHEBI:17268
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
constant: false
is: SBO:0000247

metaR AMANK
name: N-acetyl-D-mannosamine kinase
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
modifier: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269

metaM Tyr ggn c
initial concentration: 1.0
is: SBO:0000247
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
initial amount: NaN
notes: FORMULA: XOH CHARGE: 0
is: CHEBI:57606
boundary condition: false
type: Species
has only substance units: false
is: HMDB00267
constant: false

metaR LNLNCGt
fast: false
reversible: true
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_253d06d5_c429_4e75_acc2_cab69d05b2ed
has only substance units: false
is: SBO:0000252
name: ABCB4
type: Species
is encoded by: hsa:5244
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P21439
constant: false

metaR r0527
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_0a97eaeb_3140_49b3_a21c_46e7ce7f177a
type: Species
initial amount: NaN
constant: false
is: Q92685
is encoded by: hsa:10195
initial concentration: NaN
has only substance units: false
name: ALG3
boundary condition: true
is: SBO:0000252

metaM 2maacoa m
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01157
name: 2-methylacetoacetyl-CoA(4-)
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: SBO:0000247
is: CHEBI:57335

metaR r1603
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110030#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_8e54cf39_736e_4d5a_b415_a306786c1952
boundary condition: true
name: PYCR1
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5831
constant: false
has only substance units: false
is: A6NFM2

http://identifiers.org/biomodels.db/MODEL1310110030#_13f7f50e_f4ec_4bfc_b5f8_4416257957b6
is encoded by: hsa:8277
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: TKTL1
boundary condition: true
is: SBO:0000252
is: B7Z7I0

metaM ppa e
initial amount: NaN
constant: false
is: HMDB00237
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: propionate
is: CHEBI:17272

metaM frdp x
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00961
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763

metaR r1164
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
name: EC:2.3.1.26
fast: false
kinetic law: MODEL1310110030#

metaR r1602
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ppa c
initial amount: NaN
name: propionate
has only substance units: false
is: CHEBI:17272
is: HMDB00237
boundary condition: false
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_17df8dc8_8a6c_4b03_93e3_ca1f492454b1
has only substance units: false
initial amount: NaN
is encoded by: hsa:BE966236
constant: false
type: Species
name: _BE966236_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM 3tetd7ecoa c
name: 3-hydroxy tetradecenoyl-7-coa
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: CHEBI:57449
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e5265587_bd7c_4bf5_9aca_a2175e066a31
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is: O95263
boundary condition: true
initial concentration: NaN
name: PDE8B
constant: false
is encoded by: hsa:8622

metaM bilglcur c
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57767
has only substance units: false
initial amount: NaN
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaR RE0344C
modifier: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110030#
name: RE0344
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaM bilglcur e
boundary condition: false
constant: false
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
type: Species
is: CHEBI:57767
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR GLNS
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
fast: false
kinetic law: MODEL1310110030#
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254

metaR S6T12g
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false

metaR GLNSERNaEx
is described by: ECO:0000269
modifier: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
type: Reaction
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM f1a g
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: F1alpha
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
type: Species

metaM cspg b l
initial amount: NaN
is: CHEBI:36005
has only substance units: false
is: HMDB02183
boundary condition: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110030#_df1de640_5ab8_45f0_8ff2_f502c40d4aed
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103
type: Species
is: SBO:0000252
is: Q6LEN5

metaM hs deg23 l
boundary condition: false
is: CHEBI:21338
type: Species
is: SBO:0000247
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02704

metaR FAEL205
fast: false
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
name: fatty-acyl-CoA elongation (n-C20:5CoA)
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
product: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_0ae77269_f98e_4c24_9bbf_13fd41c2bba9
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:107
type: Species
name: ADCY1
is: Q08828
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_76a5c8ea_a889_401f_986e_b32892c08151
name: CA13
is encoded by: hsa:377677
constant: false
initial concentration: NaN
is: Q8N1Q1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR URCN
modifier: MODEL1310110030#
reversible: false
name: URCN
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.49
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000269

metaR r1600
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaM chsterol c
initial amount: NaN
is: CHEBI:16113
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_2e3f2fea_b534_41e2_badb_8b8647e3a4d2
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:126328
initial concentration: NaN
name: NDUFA11
is: C9JT23
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2b827db0_9459_4539_90fd_3a17078931d1
is: B4DR31
constant: false
name: DPYSL2
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1808
has only substance units: false
initial concentration: NaN

metaR HOXG
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
name: Heme oxygenase 1
product: MODEL1310110030#
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.14.99.3
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reversible: false

metaM mlthf c
name: 5,10-Methylenetetrahydrofolate
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
is: CHEBI:15636
is: SBO:0000247
initial concentration: 1.0
is: HMDB01533

metaR NDPK6m
is described by: ECO:0000254
reversible: true
modifier: MODEL1310110030#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r1607
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110030#_7f8887a5_2f5b_4206_9daf_f839605ed7c8
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: DGKZ
initial concentration: NaN
is encoded by: hsa:8525
is: G3V0F6

metaR FADH2ETC
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Complex II reaction for respiratory chain
is described by: ECO:0000134
is: SBO:0000176
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r0523
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2

metaR S4TASE3ly
reversible: true
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction

metaR GLDBRAN
name: glycogen debranching enzyme
reactant: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.25
kinetic law: MODEL1310110030#
reversible: false
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (178.4) or (178.5) or (178.1) or (178.3) or (178.2) or (178.6) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.33 Confidence Level: 4 AUTHORS: PMID:1374391 NOTES:lumped reaction, combination of 4-alpha-D-glucanotransferase (2.4.1.25) and amylo-alpha-1,6-glucosidase (3.2.1.33) NCD
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_2485ec44_c562_434c_9cb3_3e0e6543b1c6
initial amount: NaN
initial concentration: NaN
is: E5KSL5
type: Species
name: DGUOK
is encoded by: hsa:1716
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR SPMS
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.16
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
is described by: ECO:0000269
name: spermidine synthase

metaM arachdcrn x
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: HMDB06523
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57368

metaR 3MOPt2im
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false

metaR r0450
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
reversible: true
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_2592cf92_1892_4a73_b284_40f58c4b8887
initial concentration: NaN
is encoded by: hsa:953
boundary condition: true
type: Species
is: SBO:0000252
name: ENTPD1
constant: false
has only substance units: false
is: Q86VV3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_61048622_f333_446c_b4c6_bbc33ce4f21f
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:145226
is: Q96NR8
name: RDH12
is: SBO:0000252

metaM cytd c
name: Cytidine
is: SBO:0000247
is: CHEBI:17562
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
is: C00475
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_70ed3bb6_9e59_46dd_9e3e_c4fb28f2ea86
initial amount: NaN
is: P24752
boundary condition: true
is encoded by: hsa:38
constant: false
name: ACAT1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM ksi deg7 l
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16953
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: HMDB00812
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 7

metaR r1606
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM chsterol e
is: CHEBI:16113
initial concentration: 1.0
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
name: cholesterol
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r2534
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#

metaM g1m8masn r
has only substance units: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
boundary condition: false
is: C05875
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0

metaR AICARte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is: SBO:0000185
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
fast: false

metaM ksii core2 deg1 l
is: CHEBI:57737
is: SBO:0000247
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
type: Species
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00868
constant: false

metaM ala L m
is: CHEBI:16977
name: L-alanine
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00161
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
constant: false
initial concentration: 1.0

metaM CE2431 m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
name: cis-deca-4-enoyl-CoA
boundary condition: false
is: C01936
type: Species

metaR r1605
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_269e30dd_b7cf_4eca_9ae1_1b73301c3dc1
has part: Q14442
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9091
has part: O94777
type: Species
is: SBO:0000297
has part: Q92535
is encoded by: hsa:5283
is encoded by: hsa:8818
is encoded by: hsa:5279
boundary condition: true
is encoded by: hsa:51227
has part: Q9BRB3
has part: B3KUV7
is encoded by: hsa:5277

metaM uri c
is: HMDB00296
constant: false
is: SBO:0000247
name: Uridine
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: CHEBI:16704
is: C00299
has only substance units: false

metaR r0236
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110030#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5b16e93f_e37b_4676_927d_a4d6747b1d45
is: SBO:0000252
initial amount: NaN
name: _AI972237_1_c
constant: false
boundary condition: true
is encoded by: hsa:AI972237
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_4c5f7be3_a762_4b6e_9a29_4c40739cac65
is encoded by: hsa:9091
boundary condition: true
is: Q9BRB3
type: Species
has only substance units: false
initial concentration: NaN
name: PIGQ
initial amount: NaN
is: SBO:0000252
constant: false

metaR r2395
fast: false
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_689f597a_e149_4f68_9372_f75321f40d1e
initial concentration: NaN
constant: false
has only substance units: false
name: FUT8
initial amount: NaN
type: Species
is encoded by: hsa:2530
is: SBO:0000252
boundary condition: true
is: B4DFS7

metaM ksii core4 l
boundary condition: false
is: HMDB01014
has only substance units: false
initial amount: NaN
is: CHEBI:57255
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
type: Species

metaR r1604
product: MODEL1310110030#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
type: Reaction

metaR NDPK6n
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110030#_17cff031_4aac_4b71_852a_a9eecf2b98de
is encoded by: hsa:5148
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial amount: NaN
constant: false
boundary condition: true
has part: P18545
type: Species
is: SBO:0000297
initial concentration: NaN
has only substance units: false
has part: O43924
is encoded by: hsa:5147

metaR FTHFL
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: Formate-tetrahydrofolate ligase
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5

metaM f1a l
boundary condition: false
name: F1alpha
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
type: Species
is: CHEBI:17151
initial amount: NaN
is: HMDB02917
has only substance units: false
initial concentration: 1.0

metaR ADKd
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110030#
name: adenylate kinase (d form)
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110030#
reversible: true
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176

metaR r2532
is: SBO:0000185
fast: false
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_a0e9b667_783b_4b5f_9f02_091e8559f860
has only substance units: false
is: Q96C36
constant: false
name: PYCR2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:29920

http://identifiers.org/biomodels.db/MODEL1310110030#_6f21d3f6_11d8_4352_a266_bf2dd4acfa79
type: Species
initial concentration: NaN
constant: false
name: GALNS
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2588
is: P34059
has only substance units: false
initial amount: NaN

metaM vacc e
constant: false
initial concentration: 1.0
is: CHEBI:30828
is: SBO:0000247
initial amount: NaN
name: trans-vaccenate
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+

http://identifiers.org/biomodels.db/MODEL1310110030#_0dde4a7a_647a_43ab_a431_c9cc9a360306
is encoded by: hsa:AI440329
name: _AI440329_1_r
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR P450SCC1m
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
name: cholesterol monooxygenase
fast: false
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

http://identifiers.org/biomodels.db/MODEL1310110030#_bf3c7294_48ff_40f1_9bf6_b9ed14d18fc7
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: Q5QPH3
name: ACSS2
is encoded by: hsa:55902
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d17b1114_9ffa_4f31_9287_c1fa8517ebc5
boundary condition: true
is encoded by: hsa:51733
is: SBO:0000252
constant: false
has only substance units: false
name: UPB1
initial amount: NaN
initial concentration: NaN
is: B3KNC1
type: Species

metaM cytd e
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
boundary condition: false
is: SBO:0000247
name: Cytidine
constant: false
is: CHEBI:17562
initial amount: NaN
initial concentration: 1.0
is: C00475
has only substance units: false
type: Species

metaM 7dhf e
name: heptaglutamyl folate (DHF)
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06559
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_ce5ba03c_dbb3_46b8_96b2_71272675f8bf
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: GLO1
constant: false
is: Q04760
initial concentration: NaN
is encoded by: hsa:2739

metaM acmanap c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
constant: false
is: CHEBI:58557
is: HMDB01121
type: Species

metaM cdpdag hs c
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
boundary condition: false
name: CDP-diacylglycerol(2-)
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58332

http://identifiers.org/biomodels.db/MODEL1310110030#_9564cc90_7bc2_46d7_aa8c_6c0c100fea4a
is: SBO:0000252
name: TXNRD1
is encoded by: hsa:7296
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_6c6d3ff3_050c_41c2_8c86_f06ccac8006e
is: SBO:0000252
is: Q5JZF5
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:212
name: ALAS2
constant: false

metaR G13MT L
fast: false
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.132
is described by: ECO:0000000
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#

metaM HC00695 m
constant: false
has only substance units: false
name: S-Succinyldihydrolipoamide
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false
is: CHEBI:17432
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_454c48a5_5907_4de1_8693_a6eaf1e31e51
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AI620219
name: _AI620219_1_e
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_e4a54d5a_8b58_4962_8b30_7d20b940be0e
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:6999
type: Species
is: P48775
has only substance units: false
name: TDO2
constant: false

metaM CE2420 m
is: SBO:0000247
is: CHEBI:28387
type: Species
initial concentration: 1.0
constant: false
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
boundary condition: false
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA

metaM tdcoa x
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01521
is: CHEBI:57385
constant: false
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110030#_187592af_ed9e_483d_bca9_80e12191c8e5
has only substance units: false
name: SLC23A1
initial amount: NaN
type: Species
is encoded by: hsa:9963
constant: false
boundary condition: true
is: SBO:0000252
is: Q9UHI7
initial concentration: NaN

metaR r0860
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
modifier: MODEL1310110030#
type: Reaction
name: Utilized transport
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#

metaR EICOSTETt
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM Sfglutth c
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
is: CHEBI:57688
boundary condition: false
is: HMDB01550
name: S-formylglutathionate(1-)
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaR XYLTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000185
fast: false
reversible: true
name: Xylitol transport via passive diffusion
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#

metaR S2TASE1ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110030#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176

metaR r0309
product: MODEL1310110030#
type: Reaction
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a58bc70e_d517_49d0_a731_3018421782de
name: PLCD3
initial amount: NaN
type: Species
is encoded by: hsa:113026
initial concentration: NaN
is: Q8N3E9
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR NACHEX16ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110030#_6e80fada_2259_41d9_ab5a_9c191bac4a0a
is: G3V5N0
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: FUT8
is encoded by: hsa:2530
boundary condition: true
constant: false
initial amount: NaN

metaR G14T6g
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110030#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM ala L c
constant: false
boundary condition: false
is: CHEBI:16977
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
is: HMDB00161
initial amount: NaN
type: Species
name: L-alanine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_ff046b20_574b_47f7_a861_9daeb814e6f6
is encoded by: hsa:6240
initial concentration: NaN
type: Species
is: P23921
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: RRM1

metaR PALFATPtc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_f0cf36ba_1784_49ce_85e0_fd498219cee6
type: Species
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
name: _AI971036_1_x
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM glu L m
initial concentration: 1.0
name: L-glutamate(1-)
is: HMDB00148
constant: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29985

metaR S6TASE11ly
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110030#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110030#
reversible: true

metaM cspg b e
is: CHEBI:16040
initial amount: NaN
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
type: Species
is: HMDB00630

metaR r0522
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_147276f1_9075_44c9_b0bb_17f6186e8d41
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: NDUFA5
is: Q16718
is encoded by: hsa:4698
has only substance units: false

metaR FACOAL2042
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
name: fatty-acid--CoA ligase
fast: false

metaM betald c
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: betaine aldehyde
is: HMDB01252
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
initial concentration: 1.0
has only substance units: false
type: Species

metaM mi1345p c
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01059
is: SBO:0000247
constant: false
initial amount: NaN
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895

metaR HAtly
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110030#
name: hyaluronan transport, extracellular to lysosome
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR TXASr
is described by: ECO:0000134
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.3.99.5
fast: false
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
name: Thromboxane-A synthase
reversible: false
modifier: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#

metaR UDPGALtg
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
name: UDP-Gal Golgi transport via CMP antiport
reversible: true
type: Reaction
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR URAt
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000269
name: uracil transport via facilated diffusion
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_54b01248_c570_4e1b_b44a_ef5af610b2da
constant: false
boundary condition: true
initial concentration: NaN
name: NMNAT2
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23057

metaM HC01397 m
constant: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
type: Species
is: CHEBI:27402
boundary condition: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM arachdcrn m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
is: CHEBI:57387
initial amount: NaN
is: HMDB01322
constant: false
name: C20:4 carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_c0f34906_1b18_4cab_a020_d659f7e48c66
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AKR1C1
is encoded by: hsa:1645
is: SBO:0000252
constant: false
is: Q04828

metaM ala L e
constant: false
is: HMDB00161
initial concentration: 1.0
is: CHEBI:16977
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110030#_e8e3bb0d_0969_49e2_8dbd_743bebc90913
name: CHKA
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1119
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_5fbc3f9c_ad6c_49ac_8a64_7c664260edf4
constant: false
initial concentration: NaN
name: _AA081045_1_e
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110030#_02444b78_2edc_4708_98bf_17fa97363e66
is encoded by: hsa:762
name: CA4
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6FHI7
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_49137fa4_80e9_42cf_b40a_fc05cc4580e3
is: SBO:0000252
boundary condition: true
name: FLAD1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80308
type: Species
has only substance units: false
constant: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM udpglcur c
is: C00167
constant: false
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58052
is: HMDB00935
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a7ba4a84_947a_4be0_a297_8ec0a87d1f77
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:8704
name: B4GALT2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cbdab0ae_00bb_4b52_a7dd_e31c4b8d4ce0
boundary condition: true
type: Species
is: O75438
initial amount: NaN
initial concentration: NaN
name: NDUFB1
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4707

metaM glygn1 c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00187
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02133
has only substance units: false
name: glycogen, structure 1 (glycogenin-11[1,4-Glc])
is: CHEBI:17115
boundary condition: false
constant: false
type: Species

metaM duri n
boundary condition: false
has only substance units: false
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
is: HMDB00012
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: 2'-deoxyuridine

metaR NCNt
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
is described by: ECO:0000269
product: MODEL1310110030#
is: SBO:0000185

metaM 3pg c
is: CHEBI:58272
name: 3-Phospho-D-glycerate
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00807
constant: false
initial amount: NaN
boundary condition: false
is: C00197
is: http://identifiers.org/pubchem.compound/3497

http://identifiers.org/biomodels.db/MODEL1310110030#_680b1b92_49f9_492e_9922_7599ee47d765
is: Q5DSZ6
constant: false
is: SBO:0000252
is encoded by: hsa:54576
has only substance units: false
boundary condition: true
name: UGT1A8
initial amount: NaN
type: Species
initial concentration: NaN

metaR RE2814M
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
name: RE2814
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false

metaR UMPK2n
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
name: UMP kinase (CTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110030#_d99352c6_0afb_4e3b_baa7_365e3d096e90
is: SBO:0000252
is encoded by: hsa:5335
has only substance units: false
boundary condition: true
name: PLCG1
constant: false
type: Species
is: P19174
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7f27c7a5_713c_4113_a9d5_01e627577412
constant: false
initial amount: NaN
is encoded by: hsa:AL048840
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AL048840_1_c
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_87832465_0485_4740_b3fd_25f804304721
is encoded by: hsa:8818
constant: false
is encoded by: hsa:5277
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
has part: P37287
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

http://identifiers.org/biomodels.db/MODEL1310110030#_1cd79683_b46f_461f_8dfb_75935202afb1
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:115584
initial amount: NaN
is: Q8WWX8
constant: false
boundary condition: true
initial concentration: NaN
name: SLC5A11

http://identifiers.org/biomodels.db/MODEL1310110030#_3e6be56c_d40b_42ca_aaf8_e3f266c4fbcd
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: RPN1
constant: false
is encoded by: hsa:6184
initial amount: NaN
is: P04843
type: Species

metaR ASCBt
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
name: L-ascorbate transport via facilitated diffusion
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reversible: true
product: MODEL1310110030#

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: NADH dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
modifier: MODEL1310110030#
reversible: false
is described by: ECO:0000134
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_913b6f31_10eb_4f39_a458_26cba995e90f
is: Q53F23
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:6916
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: TBXAS1

metaR PCt
is version of: http://identifiers.org/ec-code/3.6.3.44
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
name: phosphatidylcholine transporter
fast: false
is described by: ECO:0000269

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM 5thf e
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: HMDB06487
name: pentaglutamyl folate (THF)
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM arachdcrn r
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57368
type: Species
name: C20:4 carnitine
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
is: HMDB06523

metaR GLUDC
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Glutamate metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: PMID:1924293,PMID:8088791 NOTES:JLR- added h to balance
modifier: MODEL1310110030#
is described by: ECO:0000269
name: Glutamate Decarboxylase
product: MODEL1310110030#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_e9268e2e_83c5_4ba6_8b9a_845864457118
type: Species
initial concentration: NaN
is encoded by: hsa:728226
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: _728226_1_e

metaR r0308
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110030#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_99100f5e_8b0e_48fd_9d8b_7a55b9786d0d
is: P19623
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6723
constant: false
initial concentration: NaN
name: SRM
initial amount: NaN

metaR GK1
fast: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
reactant: MODEL1310110030#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_703bbe1f_ce4a_40db_b5c8_1ae7a34b6d43
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: O95907
is encoded by: hsa:23539
name: SLC16A8

metaR GLCAASE7ly
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110030#

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR r0670
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110030#_b9d7dc49_4509_4055_9ad0_fca2f03c6c02
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1384
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: CRAT

http://identifiers.org/biomodels.db/MODEL1310110030#_5330d661_7af0_43d2_9d2d_c9d4dbab1b2b
is encoded by: hsa:BC005314
has only substance units: false
type: Species
initial amount: NaN
name: _BC005314_1_x
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaM hs deg3 l
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 3
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16126

metaR AMPtp
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
name: AMP transporter, peroxisome
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110030#
fast: false
reversible: true

metaR SO4t4 2
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
is described by: ECO:0000269
reversible: true
fast: false

metaR PPItx
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Diphosphate transporter, peroxisome
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8985de33_9a8c_43d0_8fa3_d17612ed473f
name: _AI656480_1_m
boundary condition: true
is encoded by: hsa:AI656480
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM vitd3 c
name: calciol
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
is: CHEBI:28940
is: HMDB00876
initial amount: NaN

metaR r2106
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0f6d3830_b7b0_426c_8934_d42e5b5438a1
name: PDE9A
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5152
constant: false

metaR ALASm
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.37
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.29
name: 5-aminolevulinate synthase
is described by: ECO:0000254
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_8682922c_df40_4023_ba7c_0c8e2ef17c79
name: SLC35D1
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: Q9NTN3
is: SBO:0000252
is encoded by: hsa:23169
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_59f465b9_cdd1_4357_8752_ecd11c1486f9
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:8050
is: O00330
initial concentration: NaN
name: PDHX
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_ed2c026e_b3fe_4cdd_8662_9a2fc766fe2d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51301
initial amount: NaN
is: Q9P109
type: Species
initial concentration: NaN
constant: false
name: GCNT4
boundary condition: true

metaR PGISr
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
is described by: ECO:0000134
is: SBO:0000176
fast: false
name: Prostaglandin I2 synthase
product: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.4
type: Reaction

metaR r0974
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110030#
name: Active transport
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:

metaR FATP3t
product: MODEL1310110030#
name: fatty acid electroneutral transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: true

metaR r0016
is version of: http://identifiers.org/ec-code/1.16.3.1
reactant: MODEL1310110030#
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
is described by: ECO:0000000

metaM octa c
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: C06423
boundary condition: false
is: HMDB00482
name: octanoate (n-C8:0)
is: CHEBI:25646
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false

metaM ala D c
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:15570
is: HMDB01310
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial amount: NaN
name: D-alanine

metaM ksi pre21 g
constant: false
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 21
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
type: Species
is: SBO:0000247

metaR r2105
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_a2bb1934_f402_4f99_9d60_a9c1bc06335f
is: SBO:0000252
boundary condition: true
name: TALDO1
type: Species
has only substance units: false
is encoded by: hsa:6888
constant: false
initial concentration: NaN
initial amount: NaN
is: P37837

metaR RE3245C
name: RE3245
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_1c113620_e5eb_4683_989b_babe760ee217
is: SBO:0000252
name: ALDH3A2
constant: false
is: P51648
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:224

metaM arachdcrn c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387
has only substance units: false
initial amount: NaN
is: HMDB01322
name: C20:4 carnitine

metaR RE0565C
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false
name: RE0565

metaR DSAT
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
name: dihydrosphingosine N-acyltransferase
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

metaR r0973
fast: false
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaM doldp L r
initial amount: NaN
name: Dolichol diphosphate, human liver homolog
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
type: Species
is: CHEBI:15750

http://identifiers.org/biomodels.db/MODEL1310110030#_976db041_4e03_4a80_97d0_98743491fc7f
initial concentration: NaN
has only substance units: false
name: _AA854479_1_m
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AA854479

metaR r2104
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: true

metaM vitd3 e
name: calciol
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
is: HMDB00876
initial amount: NaN
is: CHEBI:28940

http://identifiers.org/biomodels.db/MODEL1310110030#_a0337b61_be9c_4520_a15b_3a1b8a73bf91
is: SBO:0000252
is encoded by: hsa:27124
is: Q15735
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: INPP5J

metaR SPHINGStl
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
reactant: MODEL1310110030#
name: sphingosine intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
is: SBO:0000185
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_708df3ae_01fa_4d42_b782_504a907e9bcf
is: Q8TEQ8
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:84720
initial amount: NaN
has only substance units: false
name: PIGO
initial concentration: NaN
type: Species

metaM ala D e
constant: false
boundary condition: false
is: CHEBI:15570
type: Species
is: HMDB01310
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine

metaR FAOXC200180m
modifier: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110030#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110030#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR r2103
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR KYN3OX
name: kynurenine 3-monooxygenase
notes: GENE_ASSOCIATION: (8564.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.13.9 Confidence Level: 4 AUTHORS: PMID:9237672 NOTES:NCD
modifier: MODEL1310110030#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.13.9
reversible: false

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_5ba3ae17_c7fe_4502_b67e_f1284b0bffa3
initial concentration: NaN
type: Species
is: P30049
has only substance units: false
initial amount: NaN
constant: false
name: ATP5D
boundary condition: true
is: SBO:0000252
is encoded by: hsa:513

metaR H2MTer U
kinetic law: MODEL1310110030#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
modifier: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
name: H2 mannosyltransferase, endoplasmic reticulum
is: SBO:0000176

metaR PCm
kinetic law: MODEL1310110030#
name: pyruvate carboxylase
modifier: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
is described by: ECO:0000269
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR RETI2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: retinol isomerase (9-cis)

metaR r1901
is described by: ECO:0000000
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR B3GALT3g
is described by: ECO:0000269
fast: false
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000176
name: Beta-1,3-galactosyltransferase 3
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79

http://identifiers.org/biomodels.db/MODEL1310110030#_ca019bdb_ae3d_48d3_b367_47a7c282424d
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3712
constant: false
name: IVD
is: SBO:0000252
boundary condition: true
is: B3KVI7
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7cb78e76_9839_4f17_a8b1_8f5816930e0e
is: Q92781
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: RDH5
constant: false
is encoded by: hsa:5959
has only substance units: false

metaM mlthf m
name: 5,10-Methylenetetrahydrofolate
type: Species
constant: false
is: CHEBI:15636
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00143
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_874eca9b_2786_4ea7_8ebc_f41c633c7642
initial concentration: NaN
is encoded by: hsa:1595
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q16850
is: SBO:0000252
name: CYP51A1
boundary condition: true

metaR RETI1
name: retinol isomerase (11-cis)
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false

metaR H3ETer
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1518
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_03df30f5_cbd8_45b1_8434_819e95c77d83
initial concentration: NaN
initial amount: NaN
type: Species
is: O60427
is: SBO:0000252
is encoded by: hsa:3992
name: FADS1
boundary condition: true
constant: false
has only substance units: false

metaR r2109
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_18bc3407_83e2_4dd6_8f36_9b93ae9e5a1c
initial amount: NaN
boundary condition: true
is encoded by: hsa:5130
type: Species
is: SBO:0000252
is: P49585
initial concentration: NaN
has only substance units: false
constant: false
name: PCYT1A

metaR RETH
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: false
name: retinyl ester hydrolase
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#

metaR r2108
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM m8masn r
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05876
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r0679
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0b32c162_a7a9_42ea_84e5_1b748674424c
has only substance units: false
initial amount: NaN
is: Q92911
type: Species
constant: false
name: SLC5A5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6528
is: SBO:0000252

metaR HPDCAt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_97ea2a91_76f0_4b1d_b757_6deb95426fad
initial concentration: NaN
name: IDH2
is: P48735
is encoded by: hsa:3418
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaM tdcoa m
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: C02593
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

http://identifiers.org/biomodels.db/MODEL1310110030#_ff333646_d6f3_4386_968f_7a8f86ab119e
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: O15382
is encoded by: hsa:587
is: SBO:0000252
name: BCAT2
initial concentration: NaN

metaR ALAGLNexR
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000304
reversible: true
name: L-alanine/glutamine reversible exchange
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#

metaR AG13T7g
is: SBO:0000176
modifier: MODEL1310110030#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000

metaR CORE3GTg
is: SBO:0000176
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
product: MODEL1310110030#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110030#_c8ac03d3_539e_4fc2_bc0b_661b47edff09
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GPX2
constant: false
is encoded by: hsa:2877
is: P18283

http://identifiers.org/biomodels.db/MODEL1310110030#_51432d6d_a8e9_4cc6_a9eb_912ccd700119
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:221
is: P43353
name: ALDH3B1
constant: false
initial concentration: NaN

metaM octa e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00482
type: Species
boundary condition: false
name: octanoate (n-C8:0)
is: SBO:0000247
is: CHEBI:25646
is: C06423
notes: FORMULA: C8H15O2 CHARGE: -1

metaR r2107
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110030#

metaR GLYPHEHYc
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000134
name: hydrolysis of glycylphenylalanine

http://identifiers.org/biomodels.db/MODEL1310110030#_892c4bdf_1554_42b5_8f21_de3bb94a196a
is: SBO:0000252
name: RDH10
initial amount: NaN
is: Q8IZV5
is encoded by: hsa:157506
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
is: HMDB00807
is: SBO:0000247
is: CHEBI:58272

metaR r0975
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110030#
reversible: false
product: MODEL1310110030#
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000

metaR r0010
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.6
notes: GENE_ASSOCIATION: (25841.1) or (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:12054464,PMID:1657986 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
name: hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
reactant: MODEL1310110030#

metaM guln r
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB03290
is: CHEBI:13115
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-gulonate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_db73c677_058b_4bb0_b23d_24fae6f1a159
boundary condition: true
is encoded by: hsa:6566
name: SLC16A1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: B4DKS0
has only substance units: false

metaR GALASE7ly
product: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
fast: false

metaM damp c
is: SBO:0000247
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
has only substance units: false
boundary condition: false
name: dAMP(2-)
type: Species
constant: false
initial amount: NaN
is: HMDB00905
initial concentration: 1.0
is: CHEBI:58245

metaR RPE
fast: false
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.1.3.1
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#
reversible: true
product: MODEL1310110030#
is described by: ECO:0000000

metaM utp n
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:46398
initial amount: NaN
type: Species
name: UTP(4-)
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110030#_a4c0edc4_1c1b_4268_be50_1bca886db10c
has only substance units: false
name: _J03866_1_m
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:J03866
is: SBO:0000252

metaM cs e deg1 l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
constant: false
is: HMDB00868
is: CHEBI:57737
type: Species

metaM gua e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16235
name: guanine
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
constant: false
is: HMDB00132

http://identifiers.org/biomodels.db/MODEL1310110030#_2b07080c_6444_451a_8167_2ee21d64b84d
constant: false
is: O14732
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3613
name: IMPA2

metaM ksi deg6 l
has only substance units: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 6
constant: false
is: CHEBI:12936
type: Species
boundary condition: false
initial amount: NaN

metaM pail hs c
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
is: CHEBI:57880
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM oh1 e
initial concentration: 1.0
is: HMDB01039
constant: false
notes: FORMULA: HO CHARGE: -1
is: C01328
initial amount: NaN
has only substance units: false
name: hydroxide ion
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_0e15546b_52d5_465a_acf3_588907c15311
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:151531
name: UPP2
is: O95045
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8f270f8a_f624_4fa0_ac35_ea0a83038fd9
boundary condition: true
initial concentration: NaN
name: PRPS1L1
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:221823
is: P21108
is: SBO:0000252
type: Species

metaR r2387
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185

metaM HC01842 c
is: CHEBI:31997
name: Phosphodimethylethanolamine
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

metaR HSPGtly
reversible: false
name: heparan sulfate transport, extracellular to lysosome
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM 13dampp c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
constant: false
initial concentration: 1.0
is: HMDB00002
has only substance units: false
name: trimethylenediaminium
is: CHEBI:57484

metaR OBDHc
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
name: 2-Oxobutanoate dehydrogenase, cytosolic
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM etoh e
initial amount: NaN
type: Species
is: CHEBI:16236
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: ethanol
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
has only substance units: false

metaR MANtly
is described by: ECO:0000000
name: mannose efflux from lysosome
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM 3dhguln c
initial amount: NaN
constant: false
type: Species
is: HMDB06334
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 3-dehydro-L-gulonate
initial concentration: 1.0

metaM asn L c
has only substance units: false
initial concentration: 1.0
name: L-asparagine
boundary condition: false
is: HMDB00168
is: SBO:0000247
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
is: CHEBI:17196
initial amount: NaN

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM hs deg22 l
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02704
constant: false
has only substance units: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338
initial concentration: 1.0
notes: FORMULA: C37H56NO35S CHARGE: -3
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_289aa725_fc08_4187_8f87_89a8955f1606
name: INPPL1
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: O15357
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3636
initial amount: NaN

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction

metaM idp c
is: HMDB03335
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58280
name: IDP(3-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247

metaR r2385
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
is described by: ECO:0000000

metaM prostge2 c
has only substance units: false
is: HMDB01220
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: prostaglandin E2(1-)
is: CHEBI:606564
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaM msa m
is: CHEBI:33190
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 3-oxopropanoate
type: Species
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: SBO:0000247
is: HMDB11111

metaR SERGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: true
name: L-Serine/Glycine reversible exchange
is: SBO:0000185
product: MODEL1310110030#

metaM ocdececrn m
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 11-octadecenoyl carnitine
constant: false
is: HMDB06351
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: SBO:0000247

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110030#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000

metaM gua c
is: CHEBI:16235
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
constant: false
name: Guanine
initial concentration: 1.0
is: HMDB00132

http://identifiers.org/biomodels.db/MODEL1310110030#_35e423b5_5157_4835_bef1_e4de1f03f84a
is: SBO:0000252
type: Species
name: SDHB
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6390
has only substance units: false
initial amount: NaN
constant: false
is: P21912

http://identifiers.org/biomodels.db/MODEL1310110030#_a637835d_cc2e_4310_b084_6139076da9a2
name: PDE8A
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5151
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_40e678b4_856f_4b4e_8f33_2ea570fdc44e
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:3706
name: ITPKA
has only substance units: false
initial concentration: NaN
is: P23677
initial amount: NaN

metaR PROSTGD2t
is: SBO:0000185
type: Reaction
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269
product: MODEL1310110030#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110030#
reversible: true

metaR r0668
is described by: ECO:0000000
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.2.19

metaR CAT2p
type: Reaction
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.11.1.6
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
name: catalase A, peroxisomal (ethanol)
reactant: MODEL1310110030#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.11.1.6 Confidence Level: 2 AUTHORS: PMID:19382904,PMID:19382905,PMID:8769411 NOTES:NCD

metaM fgam c
initial concentration: 1.0
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58426
has only substance units: false
constant: false
is: C04376
type: Species
is: HMDB01308

http://identifiers.org/biomodels.db/MODEL1310110030#_2f7f23a3_62e2_4186_95c7_c08c32fb36f6
name: SLC6A5
is: Q9Y345
type: Species
is encoded by: hsa:9152
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r2386
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110030#

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_51231974_1599_4ccc_a9dc_c6b8e89adb76
boundary condition: true
initial amount: NaN
name: _728637_1_c
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:728637

http://identifiers.org/biomodels.db/MODEL1310110030#_0d47227b_79bb_495e_be16_4ba9617b532e
initial amount: NaN
constant: false
is: SBO:0000252
name: CHST3
boundary condition: true
is: Q7LGC8
type: Species
has only substance units: false
is encoded by: hsa:9469
initial concentration: NaN

metaR GLCAASE8ly
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
is described by: ECO:0000269
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#

metaR AG13T18g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110030#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR PAIL HStn
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110030#

metaR DM fol
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3194a0dc_132c_4b75_8cf5_a42cd659b0ff
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ATP5G3
is encoded by: hsa:518
initial amount: NaN

metaR r0443
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
reversible: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM oagt3 hs g
is: HMDB00286
is: C00029
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
is: CHEBI:58367
boundary condition: false
type: Species
name: 9-O-Acetylated GT3
initial concentration: 1.0
is: SBO:0000247

metaR UAG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110030#
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
reversible: true

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM hs deg4 l
initial concentration: 1.0
type: Species
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16126
name: heparan sulfate, degradation product 4

metaR r0669
product: MODEL1310110030#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
reversible: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaM dolglcp L c
initial concentration: 1.0
is: CHEBI:15812
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_30487036_f6e9_458d_b894_ae703e22de25
boundary condition: true
is encoded by: hsa:9962
is: SBO:0000252
name: SLC23A2
initial concentration: NaN
constant: false
initial amount: NaN
is: Q9UGH3
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0b2f4576_dd7e_47f6_8bed_83ca44f487d9
constant: false
name: HSD3B2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3284
is: P26439
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_695ebf50_4c45_4edc_9a73_07906ac74fee
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:516
name: ATP5G1
type: Species
has only substance units: false
boundary condition: true
is: P05496

metaM dcholcoa x
name: chenodeoxycholoyl coenzyme a
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: HMDB06292
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_49bed025_599b_4b51_8614_cd781e831d84
is encoded by: hsa:AI345944
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI345944_1_m

metaR DOLPMT3 Uer
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.260
kinetic law: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
reversible: false
reactant: MODEL1310110030#

metaR r2100
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6161c721_70cb_4e9c_8458_06ec5fb911e1
is encoded by: hsa:3000
has only substance units: false
constant: false
type: Species
is: Q02846
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GUCY2D

metaM HC01610 e
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
constant: false
initial amount: NaN
name: CoproporphyrinogenI
is: SBO:0000247
is: CHEBI:28607

metaM oagt3 hs e
is: CHEBI:18421
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
initial concentration: 1.0
name: 9-O-Acetylated GT3
is: HMDB02168
type: Species
is: SBO:0000247
has only substance units: false

metaM dgdp c
constant: false
is: HMDB00960
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
name: dGDP
is: C00361

metaR AACOAT
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Acetoacetyl-CoA:acetate CoA-transferase
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_b7d695c9_8481_472d_af8f_dffc58aefe2b
is: Q16739
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:7357
has only substance units: false
name: UGCG
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_e0f0b6ab_0e09_483e_93ab_8fbea91efb15
is encoded by: hsa:221
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ALDH3B1
constant: false
is: SBO:0000252
is: P43353
type: Species

metaM 56dthm m
is: HMDB00079
initial amount: NaN
is: CHEBI:27468
type: Species
name: 5,6-dihydrothymine
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_3fe30603_2c8f_4811_a1f2_2772edc4e08a
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4645
initial concentration: NaN
name: MYO5B
is: SBO:0000252
has only substance units: false
is: Q9H6Y6

metaR COQ6m
name: Ubiquinone biosynthesis monooxgenase COQ6
reactant: MODEL1310110030#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
fast: false
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_dca88695_254f_4ed8_8dd5_7d3379c5afe3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DCK
is encoded by: hsa:1633
boundary condition: true
type: Species
is: P27707
constant: false

metaR r1172
name: EC:3.1.1.13
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9c6da038_da15_4373_b039_8fd7d497a4d0
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: VNN3
is encoded by: hsa:55350
boundary condition: true
initial amount: NaN
type: Species

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial concentration: 1.0
boundary condition: false
name: dADP(3-)
has only substance units: false
is: SBO:0000247
is: HMDB01508
type: Species
is: CHEBI:57667
initial amount: NaN

metaM oagt3 hs c
is: SBO:0000247
is: C00029
is: CHEBI:58367
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
initial amount: NaN
name: 9-O-Acetylated GT3
initial concentration: 1.0
constant: false
is: HMDB00286
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c91d3956_2642_4524_aeb2_97885e3f328f
is encoded by: hsa:80271
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q96DU7
name: ITPKC
is: SBO:0000252
constant: false
initial concentration: NaN

metaR TRPHYDRO2
is described by: ECO:0000269
reversible: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.16.4
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reactant: MODEL1310110030#

metaR r2389
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_806af649_3f08_46f4_9083_1f9f3819092f
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:115286
type: Species
initial concentration: NaN
constant: false
name: SLC25A26

metaM oh1 c
type: Species
has only substance units: false
is: HMDB01039
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
constant: false
is: C01328
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM glyc m
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
type: Species
has only substance units: false
name: Glycerol
is: SBO:0000247
constant: false
boundary condition: false
is: C00116
initial concentration: 1.0
initial amount: NaN
is: HMDB00131

http://identifiers.org/biomodels.db/MODEL1310110030#_3b8c1db0_570b_4c64_8c2c_312fb60477de
is: A0S0A7
has only substance units: false
constant: false
is encoded by: hsa:4846
is: SBO:0000252
initial amount: NaN
name: NOS3
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_20c33eb7_85cd_489b_8a6b_55964ffcc7ba
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:7991
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_42d53eb9_fd6d_4ef8_8fae_764b37bb5f6c
name: CTPS1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1503
is: P17812
initial amount: NaN
has only substance units: false

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false

metaR r2101
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185

metaM etoh c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16236
name: ethanol
type: Species
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: HMDB00108
has only substance units: false
boundary condition: false

metaM asn L e
type: Species
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
is: CHEBI:17196
initial amount: NaN
has only substance units: false
is: HMDB00168
name: L-asparagine
constant: false
is: SBO:0000247

metaM dadp n
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
is: HMDB01508
type: Species
initial concentration: 1.0
is: CHEBI:57667
boundary condition: false
name: dADP(3-)
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7dba746d_9fff_4ca2_a9a1_3a492d834d1e
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: O43677
boundary condition: true
is encoded by: hsa:4717
name: NDUFC1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_91d01bcf_c9ee_4a00_a031_09d2559c4248
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6342
constant: false
initial concentration: NaN
name: SCP2
is: C9JC79
initial amount: NaN
is: SBO:0000252

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR HISCAT1
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM CE1936 e
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:36781
type: Species
initial concentration: 1.0
constant: false
name: spermine dialdehyde
boundary condition: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936

http://identifiers.org/biomodels.db/MODEL1310110030#_1ce070cf_c682_475c_a7a2_b780ed832514
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: HEXB
is: SBO:0000252
is encoded by: hsa:3074
is: P07686

metaR PRASCS
reversible: true
product: MODEL1310110030#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269

metaR r2102
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
has only substance units: false
is: CHEBI:58528
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR DHDPBMTm
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
name: dihydroxydecaprenylbenzoate methyltransferase
modifier: MODEL1310110030#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is version of: http://identifiers.org/ec-code/2.1.1.114
is described by: ECO:0000269
product: MODEL1310110030#

metaR r1613
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaR r1827
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reversible: false
reactant: MODEL1310110030#

metaR r0517
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110030#_e979362f_e010_4d57_a292_7fc526d63169
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:54995
is: Q9NWU1
initial amount: NaN
type: Species
initial concentration: NaN
name: OXSM
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_976277e2_fd93_4989_8543_e5699ae5cdf6
initial amount: NaN
constant: false
type: Species
name: ATP5G3
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:518
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_c1ecd4aa_0b2f_4f65_9821_a69ece006eb8
constant: false
type: Species
initial concentration: NaN
is: Q7LG56
name: RRM2B
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:50484
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_e953119b_37fb_4288_8ba9_66292caea972
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
initial amount: NaN
has part: E5KS60
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000297

metaM ocdececrn c
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB06351
type: Species
boundary condition: false
name: 11-octadecenoyl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR PUNP4
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_298c11e6_7d13_415c_a66c_8429d17ad9d1
initial amount: NaN
type: Species
is: SBO:0000252
is: O75610
has only substance units: false
name: LEFTY1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10637
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c5c93e0d_7d81_4a64_b895_691e974e0876
initial concentration: NaN
is encoded by: hsa:515
type: Species
name: ATP5F1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q08ET0

metaM ksi deg34 l
constant: false
name: keratan sulfate I, degradation product 34
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16953
initial amount: NaN
type: Species
is: HMDB00812
has only substance units: false
boundary condition: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110030#_5efca821_8f09_4fd1_94b7_3546022f8817
is: E7ET32
is encoded by: hsa:2592
initial amount: NaN
constant: false
has only substance units: false
name: GALT
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM ptdcacoa m
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
boundary condition: false
name: pentadecanoyl Coenzyme A
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB06499

http://identifiers.org/biomodels.db/MODEL1310110030#_293084f5_cfe8_4ba3_ae92_c25357e1382a
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI926493_1_m
is encoded by: hsa:AI926493
constant: false
type: Species
initial amount: NaN

metaR r1612
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
fast: false

metaM Lcystin c
type: Species
initial concentration: 1.0
is: HMDB00192
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: SBO:0000247
name: L-cystine
is: CHEBI:16283

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR r2380
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110030#
fast: false
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
reversible: true
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR PI34P5K
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c5e8516b_c41a_46cd_8805_d65ed61a1eb0
type: Species
is encoded by: hsa:65263
has only substance units: false
is: Q53H96
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PYCRL
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_6aafca3f_f7f4_4009_997e_523304d12daa
is encoded by: hsa:2987
name: GUK1
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q16774
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_f05f2f93_9631_4ec4_b482_ea897356d8ed
is: P28907
name: CD38
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:952
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaM CE4876 r
name: delta12-Prostaglandin J2
type: Species
initial concentration: 1.0
is: CHEBI:15748
has only substance units: false
is: HMDB00127
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r1615
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR UMPK4n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110030#
name: UMP kinase (GTP),nuclear
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction

metaR DRPA
reactant: MODEL1310110030#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110030#
name: deoxyribose-phosphate aldolase
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176

metaR PRPPS
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: phosphoribosylpyrophosphate synthetase
reversible: true
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.6.1

http://identifiers.org/biomodels.db/MODEL1310110030#_1bf91804_065e_4408_a042_20dafe7d6a78
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110030#_58b69dd7_cf58_476e_85e1_f794a7083c46
has only substance units: false
constant: false
is: P33908
is: SBO:0000252
is encoded by: hsa:4121
boundary condition: true
type: Species
name: MAN1A1
initial amount: NaN
initial concentration: NaN

metaM CE1939 e
name: spermidine monoaldehyde 1
has only substance units: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:36781
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_c58d7e84_6bf6_41d6_9686_9096579742f8
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: HAO2
constant: false
is encoded by: hsa:51179
has only substance units: false
initial amount: NaN

metaR ACACt2
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
modifier: MODEL1310110030#
reversible: true
is: SBO:0000185
product: MODEL1310110030#
name: acetoacetate transport via proton symport
fast: false

metaR RE3626M
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: RE3626
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: false
fast: false

metaR r1614
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
reversible: true

metaM 3dsphgn c
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
type: Species
is: HMDB01480
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58299
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
initial amount: NaN

metaR MAL Lte
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: Transport of L-malate
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_e3718ca7_c275_4259_a065_12470b253898
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:509
constant: false
has part: P25705
has part: Q6I9V2
type: Species
is encoded by: hsa:498
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000297

metaR SPHK21c
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
reversible: false
fast: false
is described by: ECO:0000269
name: sphingosine kinase 2
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176

metaM Lcystin e
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
initial concentration: 1.0
name: L-cystine
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16283
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_097ca888_d735_4ae6_9d9a_7531daf52117
constant: false
initial amount: NaN
initial concentration: NaN
name: PDE8A
is encoded by: hsa:5151
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR RE0935E
is: SBO:0000176
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: true
name: RE0935
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
modifier: MODEL1310110030#

metaR RDH1a
is version of: http://identifiers.org/ec-code/1.1.1.300
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110030#
reversible: true
name: retinol dehydrogenase (all-trans,NADPH)
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_53640aae_f6d0_4548_a372_487c211f3702
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: _AU149534_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AU149534

metaR PUNP7
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
kinetic law: MODEL1310110030#
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
is described by: ECO:0000269
reversible: true
type: Reaction

metaM utp e
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: UTP(4-)
has only substance units: false
is: CHEBI:46398
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110030#_a67bafd9_a192_47d0_b2e1_b25d255abc81
name: _AI222095_1_m
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095

metaM prostge2 e
type: Species
constant: false
initial amount: NaN
name: prostaglandin E2(1-)
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial concentration: 1.0

metaM pan4p c
is: HMDB01416
type: Species
initial concentration: 1.0
is: C01134
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
initial amount: NaN
name: Pantetheine 4'-phosphate
constant: false

metaR RE1530C
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
product: MODEL1310110030#
reversible: true
type: Reaction
name: RE1530
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR r0224
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110030#

metaR r1617
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction

metaR MALSO4tm
is: SBO:0000185
type: Reaction
reversible: true
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_88690b0c_c514_4319_9176_7f2c0bcb46bc
is encoded by: hsa:5106
name: PCK2
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q16822

metaR RPI
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110030#
modifier: MODEL1310110030#
name: ribose-5-phosphate isomerase
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#

metaR ASCBt4
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
name: L-ascorbate transport via proton symport
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is described by: ECO:0000269
reversible: true
is: SBO:0000185

metaR RE1807C
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000176
fast: false
product: MODEL1310110030#
type: Reaction
reversible: true
name: RE1807

http://identifiers.org/biomodels.db/MODEL1310110030#_19cf2773_0457_427c_a820_eb12901b1335
initial concentration: NaN
name: COQ6
type: Species
is: SBO:0000252
constant: false
is: Q9Y2Z9
has only substance units: false
boundary condition: true
is encoded by: hsa:51004
initial amount: NaN

metaR r0441
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110030#

metaR r1616
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM ksii core4 pre9 g
boundary condition: false
constant: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28067

metaM utp c
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
has only substance units: false
is: HMDB00285
constant: false
is: C00075
name: UTP
is: CHEBI:46398
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

metaR PUNP1
name: purine-nucleoside phosphorylase (Adenosine)
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9320587a_9bb5_4ca9_9a2a_5d48007a6be6
is: SBO:0000252
is: O95954
boundary condition: true
name: FTCD
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:10841
has only substance units: false

metaR r2384
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
reversible: false
modifier: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM dcholcoa r
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a

metaM pail45p hs c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28910
type: Species
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM pan4p e
name: Pantetheine 4'-phosphate
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:47942
is: C01134
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: SBO:0000247

metaR r1619
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM guln c
name: L-gulonate
type: Species
is: SBO:0000247
is: HMDB03290
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:13115
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN

metaR FUCASE2ly
fast: false
modifier: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reactant: MODEL1310110030#
name: alpha-fucosidase, lysosomal
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51

metaR L LACt2r
fast: false
name: L-lactate reversible transport via proton symport
is described by: ECO:0000269
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110030#

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM 3hbcoa m
initial concentration: 1.0
is: CHEBI:57316
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: HMDB01166
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

metaM idp e
is: SBO:0000247
has only substance units: false
name: IDP(3-)
constant: false
type: Species
is: CHEBI:58280
boundary condition: false
initial amount: NaN
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0

metaM 56dthm c
initial concentration: 1.0
constant: false
is: CHEBI:27468
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
type: Species
is: HMDB00079
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_37c7cc29_a122_4bde_b504_e8f09bb3fa97
has only substance units: false
is encoded by: hsa:8706
boundary condition: true
is: SBO:0000252
is: Q8TDY1
type: Species
constant: false
name: B3GALNT1
initial concentration: NaN
initial amount: NaN

metaM asn L m
name: L-asparagine
is: CHEBI:17196
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00168
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR NDPK7n
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
product: MODEL1310110030#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000304

metaR r1618
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_1e479409_8124_429e_ac22_2ca9102a879e
is: O14521
name: SDHD
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6392
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r0512
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR PUNP3
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110030#

metaR SIAT4Bg
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9556d42e_3be1_4185_81e8_b8139da0275d
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: PIGN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:23556

http://identifiers.org/biomodels.db/MODEL1310110030#_8d25c3d8_d46a_4dc3_988c_7f33bf0711e0
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:23632
name: CA14
initial amount: NaN
constant: false
is: A8K3J4

metaR DM T antigen g
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r2382
modifier: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reactant: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1a342278_b975_4b35_b5bb_1172990741ed
initial concentration: NaN
boundary condition: true
constant: false
is: P49619
initial amount: NaN
is: SBO:0000252
type: Species
name: DGKG
is encoded by: hsa:1608
has only substance units: false

metaR ADNCYC
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000176
name: adenylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.1
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
fast: false

metaM chsterol l
name: cholesterol
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
type: Species
is: CHEBI:16113

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR O2ter
name: O2 transport, endoplasmic reticulum
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
type: Reaction

metaR RE0827E
name: RE0827
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110030#

metaM HC00361 c
name: sedoheptulose 1,7-bisphosphate(4-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:58335

metaR SAMHISTA
is version of: http://identifiers.org/ec-code/2.1.1.8
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
is: SBO:0000176
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

metaM dolglcp L r
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812
has only substance units: false
initial concentration: 1.0

metaM ile L m
is: CHEBI:17191
constant: false
boundary condition: false
name: L-isoleucine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3bdd1580_20b6_4833_bd19_3a8a42ef83cd
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q92959
constant: false
name: SLCO2A1
is encoded by: hsa:6578
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_f2d5d8af_b1e1_47a2_a541_c54d13b7346a
name: _AI761708_1_m
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI761708
constant: false
initial concentration: NaN

metaM prostgd2 e
name: prostaglandin D2(1-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57406
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
constant: false
type: Species
is: HMDB01403
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_158a849f_1cbd_4661_a6b6_86c4b55231c2
type: Species
is encoded by: hsa:5315
name: PKM2
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P14618
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b3e7ad5f_492d_44bf_a803_417e2d6e97a2
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: Q8WXF9
is encoded by: hsa:66035
boundary condition: true
name: SLC2A11
initial concentration: NaN

metaR r0870
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.3.4
fast: false

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
name: phosphatidylinositol 4,5-bisphosphate
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28910
initial amount: NaN
is: SBO:0000247

metaM pglyc hs c
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02704
is: CHEBI:21338
is: SBO:0000247
name: pglyc_hs[c]
initial amount: NaN
boundary condition: false
notes: FORMULA: CHARGE: 0

metaM dadp c
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
is: CHEBI:57667
type: Species
is: SBO:0000247
is: HMDB01508
constant: false
boundary condition: false
name: dADP
is: C00206
initial amount: NaN

metaR RE0453M
is: SBO:0000176
reversible: true
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: RE0453
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#

metaR LACLt
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110030#
reversible: false
name: Lactate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_414292d2_1aa8_4597_ba94_a4898543beb8
initial concentration: NaN
is encoded by: hsa:2618
constant: false
name: GART
type: Species
boundary condition: true
is: P22102
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM galgluside hs g
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247
initial amount: NaN
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: HMDB00295
has only substance units: false
is: C00015
type: Species

metaM taur x
type: Species
initial concentration: 1.0
has only substance units: false
name: taurine
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00251
is: CHEBI:15891
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: SBO:0000247

metaR G14T5g
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110030#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110030#_4d0b1479_9269_40b6_a0b3_51d091fcbf40
is: SBO:0000252
is encoded by: hsa:AI435857
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AI435857_1_x
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_e30f9df5_b827_4502_b2f2_68d372bbb00a
is: Q9BX95
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: SGPP1
is encoded by: hsa:81537
constant: false

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR RE0453N
kinetic law: MODEL1310110030#
name: RE0453
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110030#

metaR DNDPt16m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269
name: dUDP transport via dADP antiport
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
reversible: false
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_c7fd078b_5b96_42a9_be85_496d03d098a3
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:57419
type: Species
is: SBO:0000252
is: Q9HC58
initial concentration: NaN
constant: false
name: SLC24A3

metaM pap g
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
constant: false
is: HMDB00061

http://identifiers.org/biomodels.db/MODEL1310110030#_6c23d3b2_6108_42b0_a6f1_3d55fc38eb64
initial amount: NaN
is: Q9NS82
is: SBO:0000252
constant: false
name: SLC7A10
is encoded by: hsa:56301
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM etoh x
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00108
type: Species
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
name: ethanol
is: CHEBI:16236

metaR AICART
type: Reaction
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_dfacf5a4_23d3_49e6_b8db_ac1c95498aed
initial concentration: NaN
initial amount: NaN
is: P05187
is encoded by: hsa:250
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: ALPP

http://identifiers.org/biomodels.db/MODEL1310110030#_6cfc7c28_64d0_4983_9701_08d7b5ac8b10
boundary condition: true
initial amount: NaN
has only substance units: false
name: EHHADH
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: Q9NY65
is encoded by: hsa:1962

metaM pglyc hs e
constant: false
name: phosphatidylglycerol(1-)
is: CHEBI:60523
type: Species
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_204d750d_26cc_48a7_8c7e_63fda2f60bf8
initial amount: NaN
name: DOLPP1
type: Species
boundary condition: true
constant: false
is encoded by: hsa:57171
initial concentration: NaN
is: Q86YN1
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_af51297a_45a9_451a_9bb6_11375b19e757
is: SBO:0000297
initial amount: NaN
name: NME1:NME2
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110030#_68aef978_ce5a_4a1b_b54c_3eca0e41f416
initial concentration: NaN
has only substance units: false
constant: false
name: ADCY9
is: SBO:0000252
type: Species
is: O60503
boundary condition: true
is encoded by: hsa:115
initial amount: NaN

metaM pan4p m
is: CHEBI:47942
is: HMDB01416
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
name: pantetheine 4'-phosphate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_13c522d1_9c82_4365_8905_469717cf6799
is: P42765
has only substance units: false
initial amount: NaN
constant: false
name: ACAA2
type: Species
is: SBO:0000252
is encoded by: hsa:10449
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_83e4d5ec_3301_4dd8_9c00_8db69cd41a0f
is encoded by: hsa:374907
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: B3GNT8
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM ksi pre7 g
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 7
is: HMDB00175
initial concentration: 1.0
constant: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110030#_7393526c_549e_41a8_baec_f5ad0e530993
is: SBO:0000252
constant: false
is encoded by: hsa:112
type: Species
initial concentration: NaN
boundary condition: true
name: ADCY6
initial amount: NaN
has only substance units: false

metaM pail hs n
type: Species
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
initial amount: NaN

metaR CRNtuNa
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
name: L-carnitine inward transport by Na+ symport

metaR r2201
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110030#
reversible: true
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_17d072b8_6af4_4328_a2b7_33ef9e4bd130
is encoded by: hsa:518
has part: P18859
is encoded by: hsa:10476
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:515
has only substance units: false
constant: false
has part: P24539
has part: O75947
is: SBO:0000297
is encoded by: hsa:522
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species

metaR LDH D
fast: false
is described by: ECO:0000304
name: D-lactate dehydrogenase
reversible: true
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)

metaM zymst r
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: zymosterol
has only substance units: false
is: HMDB06271
initial concentration: 1.0
is: CHEBI:18252
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437

metaM air c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58592
type: Species
is: HMDB01235
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
constant: false
is: C03373

http://identifiers.org/biomodels.db/MODEL1310110030#_c779e7bb_2ce5_416b_be48_6a80bfb22e78
constant: false
type: Species
boundary condition: true
is encoded by: hsa:8813
is: SBO:0000252
is: O60762
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: DPM1

metaM galgluside hs c
is: HMDB06535
constant: false
boundary condition: false
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR GARFT
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
name: phosphoribosylglycinamide formyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.2
is: SBO:0000176
modifier: MODEL1310110030#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaR r2200
is described by: ECO:0000000
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM 3hmbcoa m
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57312
is: HMDB01356
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
constant: false
boundary condition: false
initial concentration: 1.0

metaR DM ethamp r
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM idour l
boundary condition: false
initial amount: NaN
is: HMDB02704
initial concentration: 1.0
constant: false
is: CHEBI:21338
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
name: L-iduronate
type: Species

metaM 4ppcys c
is: HMDB01117
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: CHEBI:59458

metaM prostgd2 c
is: HMDB01403
type: Species
is: CHEBI:57406
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
is: SBO:0000247
boundary condition: false
name: prostaglandin D2(1-)
initial concentration: 1.0
constant: false

metaR r1610
reversible: true
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5975bdfa_4d90_47e4_804d_9e91259da340
constant: false
is: P40394
type: Species
initial concentration: NaN
is: SBO:0000252
name: ADH7
is encoded by: hsa:131
initial amount: NaN
boundary condition: true
has only substance units: false

metaR DAG HSter
is: SBO:0000185
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
name: diacylglycerol ER export
fast: false

metaR r0009
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1

metaM frdp c
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00961
initial amount: NaN
is: CHEBI:175763
name: Farnesyl diphosphate
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_81bc3263_6646_4176_8839_98b896662847
initial concentration: NaN
name: SLC4A3
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6508
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_4c3b4c55_474b_4998_b641_cc5c6a1c8f5e
has only substance units: false
is: SBO:0000252
is: O14495
initial concentration: NaN
name: PPAP2B
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8613
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_4d86e0e4_ec2c_489b_8452_5626b2cff66a
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: DGUOK
is encoded by: hsa:1716

metaM chsterol m
is: CHEBI:16113
has only substance units: false
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00067
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a7097a8d_dcbc_495c_a0b4_23118beeca92
name: _AA614647_1_c
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:AA614647
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR ABTD
reversible: true
name: L-arabinitol 4-dehydrogenase
fast: false
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000

metaM gbside hs g
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:18259
is: SBO:0000247

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR OCTAt
name: Octanoate transport via diffusion
reversible: true
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110030#

metaM spc hs e
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247
boundary condition: false
has only substance units: false
name: sphingosylphosphorylcholine
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d5affb17_5d49_4bee_992f_dfff8e83b231
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: RDH11
is encoded by: hsa:51109
type: Species
is: B4DDW0
constant: false
initial amount: NaN
has only substance units: false

metaR r2202
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110030#

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM leuktrF4 e
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: leukotriene F4
boundary condition: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247
is: CHEBI:27491
is: HMDB06465
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_375b0a5b_3f93_43b9_85a3_3a6a6699d265
is encoded by: hsa:4706
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFAB1
is: O14561
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_ec7d9fa7_df6c_4a69_9c39_74b33ee50bfe
initial concentration: NaN
name: PRPS1
has only substance units: false
constant: false
is: P60891
type: Species
is encoded by: hsa:5631
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR NACHEX17ly
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d724f191_f926_456c_950f_1859fb928684
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: NDUFS7
is: O75251
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:374291
has only substance units: false

metaR THYOXt
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110030#
name: T4 transport via bicarbonate countertransport

metaR DOLGLCP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction

metaR SFGTH
product: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.2.12
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110030#
fast: false
name: S-Formylglutathione hydralase
type: Reaction
reactant: MODEL1310110030#

metaM crm hs g
is: CHEBI:52639
name: N-acylsphingosine
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_4f4d3062_4ad4_4de1_9b6d_012ca518e4c2
is encoded by: hsa:47
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: ACLY

http://identifiers.org/biomodels.db/MODEL1310110030#_2ffffdd5_96b5_4db9_8b0a_2bd4da7230de
initial concentration: NaN
is encoded by: hsa:5281
name: PIGF:PIGO
initial amount: NaN
has only substance units: false
boundary condition: true
has part: Q07326
constant: false
is: SBO:0000297
type: Species
has part: Q8TEQ8
is encoded by: hsa:84720

metaM 4nph e
is: HMDB01232
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57917
name: 4-nitrophenolate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_82cf6f8f_a172_4fb0_8112_f4f21449695f
boundary condition: true
initial amount: NaN
is encoded by: hsa:10861
name: SLC26A1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaM gluside hs g
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:18368

metaR NACHEX9ly
fast: false
reversible: false
modifier: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM Lkynr c
has only substance units: false
name: L-kynurenine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16946
type: Species
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684
constant: false
boundary condition: false

metaM CE2421 m
is: HMDB02329
constant: false
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: SBO:0000247

metaM ksi pre34 g
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 34
is: HMDB00175
constant: false
initial concentration: 1.0
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: CHEBI:58053
has only substance units: false
is: C00130
type: Species

metaM spc hs c
has only substance units: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN

metaR r0002
is described by: ECO:0000000
fast: false
name: Active transport
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_723e3ccb_c405_44d2_a926_0e0a97199af4
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: TKTL2
is: Q9H0I9
is encoded by: hsa:84076
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM dcholcoa c
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: HMDB06292
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaM idour e
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
initial concentration: 1.0
type: Species
has only substance units: false
name: L-iduronate

metaM m2emgacpail hs r
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: C00080
is: SBO:0000247
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
has only substance units: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR KCCt
kinetic law: MODEL1310110030#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000269
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_a19f7d5e_319b_4938_b5c5_47c0b59fe6dd
boundary condition: true
is: SBO:0000252
name: PIGP
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110030#_520ca2d5_c107_4baa_8fa6_fd721a812fdf
is: O75251
boundary condition: true
name: NDUFS7
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:374291
initial concentration: NaN
is: SBO:0000252

metaR ASNS1
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
name: asparagine synthase (glutamine-hydrolysing)
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.4
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_1b3e49fd_62e2_41d0_ade9_a96074656e0e
constant: false
initial amount: NaN
is: Q9UHV8
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: LGALS13
is encoded by: hsa:29124
has only substance units: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM chsterol r
is: SBO:0000247
constant: false
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16113
has only substance units: false
initial amount: NaN

metaM HC01409 m
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:27540
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
has only substance units: false
is: SBO:0000247
name: Hexanoyl-CoA
boundary condition: false
initial amount: NaN

metaR r0660
reactant: MODEL1310110030#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d477117f_b44a_451a_9b1d_e3158117f1ed
is encoded by: hsa:8654
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: G5E9C5
name: PDE5A
has only substance units: false
is: SBO:0000252

metaR FK
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: Fucokinase
reversible: false
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.52

http://identifiers.org/biomodels.db/MODEL1310110030#_eabd48f7_9f24_48ac_97bf_b7f91e7fdff0
is: SBO:0000252
has only substance units: false
is: Q99259
boundary condition: true
is encoded by: hsa:2571
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: GAD1

http://identifiers.org/biomodels.db/MODEL1310110030#_79ef95ec_3b83_41fe_a0b3_d8b010d39ead
initial concentration: NaN
is: Q7Z725
boundary condition: true
initial amount: NaN
name: SLC34A1
constant: false
has only substance units: false
is encoded by: hsa:6569
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_ec495406_0571_482d_aae7_133c1b0af7b2
type: Species
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM thyox L c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
name: L-thyroxine
type: Species
is: CHEBI:18332
boundary condition: false
constant: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ae4e41bd_7145_420b_afea_9d5860b34144
initial concentration: NaN
constant: false
is: B3KWF4
is encoded by: hsa:63917
type: Species
boundary condition: true
has only substance units: false
name: GALNT11
is: SBO:0000252
initial amount: NaN

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
is: HMDB06460
name: arachidyl carnitine
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR GLNtm
type: Reaction
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_bebeaf63_9718_4b50_9035_f49d2940b65d
initial concentration: NaN
initial amount: NaN
name: CHAT
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
is: D3DX95

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#

metaR TALA
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.2.1.2
modifier: MODEL1310110030#
name: transaldolase
reactant: MODEL1310110030#
type: Reaction

metaM 4ppcys m
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
is: HMDB01117
constant: false
type: Species
is: CHEBI:59458
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_b02f14d6_f873_48be_b41f_4169be8f7ac9
has only substance units: false
initial amount: NaN
name: GALT
is encoded by: hsa:2592
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: B4E097
constant: false

metaR FALDtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: formaldehyde transport via diffusion (lysosomall)
product: MODEL1310110030#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_0c7ff433_90db_4ed6_94ed_9e8f2f03d674
is: O60488
constant: false
boundary condition: true
initial amount: NaN
name: ACSL4
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2182

http://identifiers.org/biomodels.db/MODEL1310110030#_a0155d1c_6387_4c9f_8378_cfce721512d4
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: _D87002_1_e
is encoded by: hsa:D87002
has only substance units: false

metaR FAOXC9C7m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM gluside hs c
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
initial amount: NaN
has only substance units: false
name: D-glucosyl-N-acylsphingosine
constant: false
type: Species
boundary condition: false
is: SBO:0000247

metaR H2CO3D
modifier: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
fast: false
reversible: true
type: Reaction
name: carboxylic acid dissociation
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.1
is: SBO:0000176

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3532fc17_f735_4740_a3b3_455f09ea9b46
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ATP5C1
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:509
is: Q6I9V2

metaM crm hs c
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: N-acylsphingosine
is: CHEBI:52639
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

http://identifiers.org/biomodels.db/MODEL1310110030#_29eb01f3_b3bc_4cdf_8833_ad53198720f2
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is encoded by: hsa:522
constant: false
type: Species
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has part: P56134
is encoded by: hsa:9551
initial amount: NaN

metaR INSTt4
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction
is: SBO:0000185
name: inositol transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110030#_1ed556a7_40c6_440d_8600_99835b8463bb
is: SBO:0000252
name: ALDH3A1
type: Species
boundary condition: true
is encoded by: hsa:218
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P30838
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_51e8c1d7_ccf6_4416_91d4_a6a7caf7daf8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79087
initial amount: NaN
is: Q9BV10
constant: false
boundary condition: true
type: Species
name: ALG12
initial concentration: NaN

metaM biliverd c
initial concentration: 1.0
is: HMDB01008
has only substance units: false
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
initial amount: NaN
name: biliverdin(2-)
boundary condition: false
type: Species
is: CHEBI:57991

metaR RE1517M
is: SBO:0000176
product: MODEL1310110030#
modifier: MODEL1310110030#
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_5373fcb1_a1cd_4c7f_aad0_0fe00d48c28d
initial concentration: NaN
has only substance units: false
has part: P31040
has part: Q99643
name: SDHA:SDHB:SDHC:SDHD
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:6392
is encoded by: hsa:6390
is encoded by: hsa:6389
is encoded by: hsa:6391
has part: O14521
constant: false
has part: P21912
type: Species

metaR r0666
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true
modifier: MODEL1310110030#

metaM HC02216 e
boundary condition: false
is: CHEBI:28922
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
name: prostaglandin-f2beta

metaM dgdp m
constant: false
is: CHEBI:58595
name: dGDP(2-)
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00960
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: CHEBI:58343
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_6a2af53e_86a0_4de2_b829_d1c68f26b9fb
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
name: UAP1
initial concentration: NaN
is: Q16222
is encoded by: hsa:6675

metaM thyox L e
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
is: HMDB00248
is: CHEBI:18332
name: L-thyroxine
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_4ef94aa4_5935_479d_ba11_8d14d6a71f4a
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10423
constant: false
is: O14735
name: CDIPT
has only substance units: false

metaM leuktrF4 c
has only substance units: false
constant: false
boundary condition: false
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial amount: NaN
type: Species
is: CHEBI:27491
is: SBO:0000247
is: HMDB06465
initial concentration: 1.0

metaM dgdp n
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
is: CHEBI:58595
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00960
name: dGDP(2-)

metaR AG13T6g
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_532cab31_ba56_4d5c_8c2f_d97231babbac
initial amount: NaN
is: SBO:0000252
name: SLC6A14
is: Q9UN76
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:11254

http://identifiers.org/biomodels.db/MODEL1310110030#_2ff451a5_889f_4339_9238_6d588cfea003
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:51557
name: LGSN
is: Q5TDP6
type: Species

metaM idour c
is: HMDB02704
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:21338
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#
name: Transport of (R)-Pantothenate

metaM 4izp c
name: 4-Imidazolone-5-propanoate
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
type: Species
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01014
is: CHEBI:57255
has only substance units: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR RE0453C
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_95ee2344_434f_4fa3_a43f_5ae9f3d67667
is: P53602
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4597
type: Species
initial amount: NaN
name: MVD

http://identifiers.org/biomodels.db/MODEL1310110030#_4ace7417_a4f8_4af3_a817_3555eed066e8
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:219
is: P30837
has only substance units: false
is: SBO:0000252
name: ALDH1B1

http://identifiers.org/biomodels.db/MODEL1310110030#_2fd40068_caac_4080_9221_a07185d20140
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6579
initial amount: NaN
constant: false
is: P46721
boundary condition: true
initial concentration: NaN
name: SLCO1A2

http://identifiers.org/biomodels.db/MODEL1310110030#_ffb44ed2_6a90_4581_a3af_a4de810a901b
boundary condition: true
is: Q13123
name: IK
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:3550
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_af0651dc_46ed_4a32_ba3f_07a4ea139bd8
name: ATP5J
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:522
is: Q6IB54
is: SBO:0000252

metaM g6p c
name: D-Glucose 6-phosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
has only substance units: false
is: C00092
is: CHEBI:61548
initial amount: NaN
boundary condition: false
is: HMDB01401
type: Species

metaM ncam e
constant: false
name: Nicotinamide
type: Species
is: CHEBI:0
initial amount: NaN
is: HMDB01406
initial concentration: 1.0
is: SBO:0000247
is: C00153
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
boundary condition: false

metaR 3HKYNAKGAT
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
kinetic law: MODEL1310110030#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_158cf5fd_de85_4e99_90bf_a23d91e32a8a
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: ATP5G2
is encoded by: hsa:517
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7904c2ac_b8b6_4e59_87aa_141f46a74e9e
is encoded by: hsa:4726
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFS6
is: Q6IBC4
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR CHOLATEt
is: SBO:0000185
fast: false
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
modifier: MODEL1310110030#
is described by: ECO:0000269
kinetic law: MODEL1310110030#

metaM glyb c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
name: glycine betaine
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17750
type: Species
is: HMDB00043
initial concentration: 1.0

metaM HC02216 c
is: CHEBI:28922
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN

metaM hpyr c
is: HMDB01352
boundary condition: false
type: Species
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17180
name: 3-hydroxypyruvate
has only substance units: false
constant: false

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
is: CHEBI:16066
is: SBO:0000247
boundary condition: false
name: 11-cis-retinal
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB02152

metaR PE HSter
name: phosphatidylethanolamine scramblase
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaR r0434
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
is described by: ECO:0000000

metaM ala B e
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
name: beta-alanine

metaR PGK
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: phosphoglycerate kinase
is version of: http://identifiers.org/ec-code/2.7.2.3
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
type: Reaction
reactant: MODEL1310110030#
fast: false

metaR S6TASE14ly
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM taur e
initial amount: NaN
is: C00245
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: CHEBI:3544
name: Taurine
boundary condition: false

metaR r0735
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000176
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110030#_9f5f83a0_d74d_4864_b69b_44f80a7e44e7
is encoded by: hsa:3032
is: SBO:0000252
type: Species
initial amount: NaN
name: HADHB
is: P55084
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_822eb1e8_db2f_4681_bd02_81a1314cbf12
name: VNN2
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: A8K7W0
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8875

metaM bildglcur c
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_060b4d9c_1566_4879_9384_35b992d04597
constant: false
type: Species
has only substance units: false
name: HSD3B1
is: P14060
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3283

http://identifiers.org/biomodels.db/MODEL1310110030#_cbf8e5b7_2c63_4490_93d5_9d6fc5f55f5f
type: Species
is: SBO:0000252
name: ABCB4
initial amount: NaN
is encoded by: hsa:5244
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_15e84e0e_3491_4d3a_9369_0c950c7654e5
is: SBO:0000252
name: PANK1
is encoded by: hsa:53354
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q8TE04
constant: false

metaM pmtcoa c
is: CHEBI:3454
type: Species
is: HMDB01338
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154

metaR HIStiDF
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
name: L-histidine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reversible: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR S6T10g
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110030#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
type: Reaction

metaM fmn c
is: C00061
is: HMDB01520
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
boundary condition: false
type: Species
initial amount: NaN
name: FMN
is: SBO:0000247
is: CHEBI:58210
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_3439f007_b14f_45d7_913b_22c21115f81c
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ATP5J2
initial amount: NaN
boundary condition: true
constant: false
is: F8W7V3
is encoded by: hsa:9551

metaR r1299
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
name: Vesicular transport
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaM taur c
constant: false
name: Taurine
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00251
has only substance units: false
is: CHEBI:3544
is: C00245
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0

metaM accoa r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
name: acetyl-CoA(4-)
is: HMDB01206
boundary condition: false
is: SBO:0000247
is: CHEBI:57288
constant: false
initial amount: NaN

metaR r0733
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR RE1447N
kinetic law: MODEL1310110030#
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM gluside hs l
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR RNMK
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000176
fast: false
name: ribosylnicotinamide kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.22
is described by: ECO:0000269
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_065bb1be_fba8_4675_8e64_00398bb89445
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AF116616
boundary condition: true
name: _AF116616_1_m

http://identifiers.org/biomodels.db/MODEL1310110030#_82a0cf2b_d57f_45a8_a324_f384ab495c6f
constant: false
is: SBO:0000297
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:514
has only substance units: false
is encoded by: hsa:513
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

http://identifiers.org/biomodels.db/MODEL1310110030#_6b17147d_9470_4727_ab48_514a40461297
has only substance units: false
is: SBO:0000252
name: NDUFV3
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4731
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8cec8a76_e4e5_4694_ad62_15b9a78e8eb9
has only substance units: false
is encoded by: hsa:AW299740
name: _AW299740_1_m
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR r2516
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0437
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
fast: false
modifier: MODEL1310110030#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.1.2.13

metaM bildglcur e
is: CHEBI:58471
boundary condition: false
is: HMDB03325
initial amount: NaN
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
is: SBO:0000247
has only substance units: false

metaM nadph m
type: Species
constant: false
is: CHEBI:57783
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
initial concentration: 1.0

metaR r1298
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
product: MODEL1310110030#
fast: false

metaR PI45PLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#

metaR DM atp c
reversible: false
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
fast: false
type: Reaction
reactant: MODEL1310110030#

metaR THRALANaEx
modifier: MODEL1310110030#
is described by: ECO:0000269
fast: false
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM HC01405 m
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
is: CHEBI:28632
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7a275d2c_7aca_458e_a050_abb46a89db7e
is: SBO:0000252
type: Species
name: SLC4A9
has only substance units: false
is: E9PDK1
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:83697

metaR r0734
type: Reaction
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
reversible: false
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM HC01522 c
constant: false
name: Gentisate aldehyde
is: SBO:0000247
is: CHEBI:28508
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2a1384b5_98db_4ea2_aaa2_f4d540b6c210
is: P21953
boundary condition: true
name: BCKDHB
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:594
is: SBO:0000252

metaR FAOXC121C10x
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR FMNAT
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: FMN adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is described by: ECO:0000134

metaM retn e
is: HMDB01852
boundary condition: false
has only substance units: false
name: all-trans-retinoate
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: CHEBI:35291
constant: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_aa821610_f2d1_4163_a380_71a1a8cd4a78
has only substance units: false
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RE3050R
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
name: RE3050
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_57f1b7e7_5f51_4f37_92ae_267f4bb2c6f0
is: SBO:0000252
has only substance units: false
is: P22234
is encoded by: hsa:10606
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: PAICS

metaM gluside hs r
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
boundary condition: false
constant: false
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
has only substance units: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_562cf197_d753_4953_a1b5_d2290d180967
constant: false
name: NDUFV3
has only substance units: false
type: Species
is encoded by: hsa:4731
is: P56181
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r0731
fast: false
product: MODEL1310110030#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110030#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_bae3d0b9_44b6_4b27_854e_5d123ae6eff5
constant: false
has only substance units: false
boundary condition: true
type: Species
is: P19961
is encoded by: hsa:280
initial amount: NaN
name: AMY2B
is: SBO:0000252
initial concentration: NaN

metaM accoa x
is: HMDB01206
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: C00024
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
name: Acetyl-CoA
is: CHEBI:57288

metaR PROt4 2 r
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Proline transport (sodium symport) (2:1)
fast: false
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
is described by: ECO:0000006

metaM hLkynr c
is: HMDB11631
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
name: 3-hydroxy-L-kynurenine
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17380

http://identifiers.org/biomodels.db/MODEL1310110030#_f288a809_b029_4445_80f5_97964154f2a6
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: PKLR
initial concentration: NaN
is: P30613
constant: false
is encoded by: hsa:5313

metaR PSt3
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport
is described by: ECO:0000269
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b3106e46_95f4_4ce1_887d_edf16c2cc711
is: P00558
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PGK1
is encoded by: hsa:5230
initial amount: NaN
has only substance units: false
type: Species

metaR RE2349C
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: RE2349
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reversible: true

metaR r0732
product: MODEL1310110030#
reversible: false
type: Reaction
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false

metaM thym c
boundary condition: false
constant: false
name: Thymine
is: CHEBI:17821
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
initial concentration: 1.0
has only substance units: false
type: Species
is: C00178

http://identifiers.org/biomodels.db/MODEL1310110030#_7f61d651_215d_431e_8ca9_5f5a593b19db
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:57665
is: Q9HBH5
initial concentration: NaN
has only substance units: false
name: RDH14
type: Species

metaM nadph r
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
is: HMDB00221
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false

metaM retn c
is: SBO:0000247
type: Species
is: HMDB01852
is: CHEBI:35291
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_6dec6b7c_9860_40af_9af4_097ffde5c85f
initial amount: NaN
name: NDUFS4
type: Species
has only substance units: false
is: SBO:0000252
is: O43181
initial concentration: NaN
is encoded by: hsa:4724
boundary condition: true
constant: false

metaM ncam c
has only substance units: false
is: CHEBI:0
initial concentration: 1.0
is: C00153
is: HMDB01406
initial amount: NaN
is: SBO:0000247
name: Nicotinamide
notes: FORMULA: C6H6N2O CHARGE: 0
type: Species
constant: false
boundary condition: false

metaR TMDK1m
product: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.21
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
name: thymidine kinase (ATP:thymidine)
fast: false

metaR ACACT1r
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
name: acetyl-CoA C-acetyltransferase
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d9c71211_ce2e_4b6a_9829_9d8d12490309
type: Species
is: P19801
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: ABP1
initial amount: NaN
is encoded by: hsa:26

http://identifiers.org/biomodels.db/MODEL1310110030#_773deca9_39a8_4b2f_a860_7f034b49777a
has only substance units: false
is encoded by: hsa:55343
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: SLC35C1
type: Species
is: B3KQH0

metaR GALGLUSIDEtg
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
product: MODEL1310110030#
fast: false
name: galgluside hs intracellular transport
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_c9607739_c350_45c7_acef_58d572e11931
boundary condition: true
name: ATP5G1
is: Q6FIH7
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:516

http://identifiers.org/biomodels.db/MODEL1310110030#_6ca8f51f_d42a_494d_9a90_b1bb1923d023
is: SBO:0000252
name: NDUFA11
is encoded by: hsa:126328
type: Species
initial amount: NaN
is: C9JT23
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaR CDS
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: phosphatidate cytidylyltransferase
product: MODEL1310110030#

metaM hs deg6 l
has only substance units: false
is: HMDB06254
name: heparan sulfate, degradation product 6
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_d69da996_12f2_43f1_b208_e484695317bb
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:9187
name: SLC24A1
is: SBO:0000252
has only substance units: false
constant: false
is: B4DUG1

metaM ala B m
is: HMDB00056
is: SBO:0000247
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: beta-alanine
boundary condition: false
constant: false
type: Species

metaM thym e
boundary condition: false
is: CHEBI:17821
initial amount: NaN
is: SBO:0000247
is: HMDB00262
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: thymine

metaR r0730
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
fast: false
reversible: false

metaM ksi deg16 l
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 16
boundary condition: false
is: CHEBI:16953
has only substance units: false
type: Species
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
constant: false
initial concentration: 1.0
is: HMDB00812

metaM mthgxl c
initial amount: NaN
boundary condition: false
is: CHEBI:17158
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
is: HMDB01167
name: methylglyoxal
is: SBO:0000247

metaR BPNT
type: Reaction
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
fast: false
is: SBO:0000176
name: 3',5'-bisphosphate nucleotidase
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.7
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_352d2926_8588_457f_9082_1e3d7578e6fc
is: SBO:0000252
is: Q85KV6
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:4535
name: ND1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_82a19bc0_0247_48aa_8e57_b1ae0bca284c
initial concentration: NaN
is: SBO:0000252
type: Species
name: B3GNT2
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:10678

http://identifiers.org/biomodels.db/MODEL1310110030#_56504b08_e2b2_401d_9c9f_db1098d41056
has only substance units: false
boundary condition: true
is encoded by: hsa:84693
is: Q96PE7
name: MCEE
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

metaM 4abut c
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:3628
initial amount: NaN
constant: false
is: C00334
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110030#_da0aba50_e936_44b0_a1de_8e72387b5791
name: NDUFB2
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4708
is: SBO:0000252
is: H7C5B8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_34d019bf_15c4_48b9_99b1_afa729656c2d
has only substance units: false
boundary condition: true
is: B7Z5T8
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1375
name: CPT1B
is: SBO:0000252

metaR r1700
modifier: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
name: Y+LAT2 Utilized transport

metaM nadph x
is: CHEBI:57783
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: C00005
initial amount: NaN
is: HMDB00221
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR r0321
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
modifier: MODEL1310110030#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction
product: MODEL1310110030#

metaR GLCtly
fast: false
product: MODEL1310110030#
reversible: false
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: glucose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

metaR r0547
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110030#

metaR DUMPtn
name: dUMP nuclear transport
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR 5MTAte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
name: Transport of 5-S-methyl-5-thioadenosine
product: MODEL1310110030#

metaR GALGLUSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
name: galgluside hs intracellular transport
is: SBO:0000185
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#

metaM ksi deg36 l
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial concentration: 1.0
constant: false
is: HMDB00143
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 36
initial amount: NaN
type: Species
is: CHEBI:12936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_3968180f_a8ef_46e2_97d4_45ea0fe67755
has only substance units: false
is encoded by: hsa:277
boundary condition: true
initial concentration: NaN
type: Species
is: P04745
initial amount: NaN
constant: false
is: SBO:0000252
name: AMY1B

metaM chito2pdol L c
is: CHEBI:12427
constant: false
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
boundary condition: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01196
type: Species
initial concentration: 1.0

metaM core3 g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16250
name: Core 3

http://identifiers.org/biomodels.db/MODEL1310110030#_8436052c_ac2c_4819_9b2f_1a1b04356c3e
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: O75038
is encoded by: hsa:9651
is: SBO:0000252
name: PLCH2

http://identifiers.org/biomodels.db/MODEL1310110030#_35704258_3683_47c0_bbd1_a0a6fb7c1104
is encoded by: hsa:D87002
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: _D87002_1_m
type: Species
boundary condition: true
initial concentration: NaN

metaR r1291
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
fast: false
is: SBO:0000185
type: Reaction
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8e7e15b1_cb14_4908_934a_818176e27184
type: Species
is: Q9Y666
boundary condition: true
name: SLC12A7
is encoded by: hsa:10723
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR G14T14g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR NCKt
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Na+/Ca2+-K+ exchange
is: SBO:0000185
kinetic law: MODEL1310110030#

metaM 4abut e
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:3628
name: 4-Aminobutanoate
type: Species
constant: false
has only substance units: false
is: C00334
is: HMDB00112

metaR UMPK5n
is described by: ECO:0000269
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
name: UMP kinase (dATP),nuclear

metaM xol24oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
is: CHEBI:34310
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (24S)-24-hydroxycholesterol
initial amount: NaN
constant: false
is: HMDB01419
is: SBO:0000247

metaR r0549
is described by: ECO:0000000
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/6.1.1.17
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6d4aac9c_191d_42bd_8c80_2c679e5e2a29
type: Species
name: PRDX3
has only substance units: false
is: E9PH29
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:10935
initial amount: NaN
boundary condition: true

metaR PCRNtm
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
kinetic law: MODEL1310110030#
reversible: false
fast: false
is: SBO:0000185
product: MODEL1310110030#
name: transport into the mitochondria from cytosol (carnitine)

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM ksii core2 deg3 l
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
has only substance units: false
constant: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 3
is: CHEBI:12936
initial concentration: 1.0
type: Species

metaM 4aphdob c
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: HMDB00978
is: CHEBI:58147
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252

http://identifiers.org/biomodels.db/MODEL1310110030#_5d221a35_6c66_4074_948f_78985f84c9df
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: _T83654_1_m
is: SBO:0000252
boundary condition: true
is encoded by: hsa:T83654
initial concentration: NaN

metaR RE3627M
is described by: ECO:0000000
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
product: MODEL1310110030#
name: RE3627
modifier: MODEL1310110030#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110030#

metaM galgluside hs l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:12936
has only substance units: false
constant: false
boundary condition: false
name: galactosyl glucosyl ceramide
type: Species
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110030#_c59660d0_e01d_49ac_b832_2297257b18e1
is: SBO:0000252
name: SLC29A2
has only substance units: false
type: Species
is: Q14542
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3177
initial concentration: NaN

metaR CO2t
name: CO2 transporter via diffusion
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_f157057a_7e9e_4062_a9bb_f582e8bef391
has only substance units: false
constant: false
is: SBO:0000252
name: ATP5J
is encoded by: hsa:522
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR BILGLCURtr
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
name: glucuronidated compound transport

metaR ASNGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reversible: false
is: SBO:0000185
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0cece4c1_c7cb_4c77_ae21_40df349a13af
is: SBO:0000252
constant: false
name: PDE8A
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5151

http://identifiers.org/biomodels.db/MODEL1310110030#_df459713_246d_403e_baa9_d102fa891e58
is encoded by: hsa:55907
name: CMAS
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: Q8NFW8
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_6d1a7724_9962_4afe_81e5_2f265fc707c5
is encoded by: hsa:6240
name: RRM1:RRM2
has part: P31350
initial concentration: NaN
has part: P23921
is encoded by: hsa:6241
has only substance units: false
type: Species
constant: false
is: SBO:0000297
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_a0109e11_947d_41b9_87ab_1c46a15ea99f
is: SBO:0000252
type: Species
is: Q9NRZ7
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:56894
has only substance units: false
name: AGPAT3

metaM malthp e
type: Species
is: C01936
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: SBO:0000247
has only substance units: false
name: maltoheptaose
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_384e9f91_15d9_40f4_a0ec_c327466cca5b
is: SBO:0000252
is encoded by: hsa:11041
type: Species
initial concentration: NaN
name: B3GNT1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: O43505

metaR RE3520E
is described by: ECO:0000000
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
name: RE3520
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110030#

metaM ade c
name: Adenine
is: CHEBI:16708
is: C00147
is: HMDB00034
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR MEOHtly
name: Methanol transporter, lysosome
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110030#
reversible: true
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NCD

metaR GLYSARCNc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1292
name: Postulated transport reaction
is: SBO:0000185
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

metaR G14T9g
type: Reaction
modifier: MODEL1310110030#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR GALASE3ly
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR MG2er
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_aa8d80a8_adff_411d_8256_461b0dac490c
initial concentration: NaN
is encoded by: hsa:2936
name: GSR
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P00390

metaM lys L x
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
has only substance units: false
is: HMDB00182
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:32551
type: Species
is: SBO:0000247

metaR ACGPID
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.89
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
product: MODEL1310110030#
reversible: false

metaR RE0383C
reactant: MODEL1310110030#
name: RE0383
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: true
product: MODEL1310110030#
is: SBO:0000176

metaM accoa n
is: CHEBI:57288
has only substance units: false
name: acetyl-CoA(4-)
is: HMDB01206
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
constant: false

metaM txa2 r
is: HMDB01452
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57445
name: thromboxane A2(1-)
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_02443ab3_3af9_4fc4_9bc2_fd77ea25919c
is encoded by: hsa:2678
initial amount: NaN
name: GGT1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: P19440
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8b6805d3_c615_4376_a2b9_ef12ce4e3449
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: MDH2
is: P40926
initial amount: NaN
is encoded by: hsa:4191

metaR PGI
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
type: Reaction
name: glucose-6-phosphate isomerase
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b3e936f7_86b6_46b7_ab03_ffb8d6db7cd3
initial concentration: NaN
is: SBO:0000252
is: Q9NYQ3
constant: false
name: HAO2
is encoded by: hsa:51179
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaM thym m
name: thymine
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00262
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
is: CHEBI:17821

metaM 4hbzcoa m
type: Species
is: SBO:0000247
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB06467
initial amount: NaN
has only substance units: false
name: 4-hydroxybenoyl-CoA
constant: false

metaM Rtotal3coa c
type: Species
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
constant: false
boundary condition: false
is: HMDB01448
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: R total 3 Coenzyme A

metaR GALASE16ly
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110030#
reversible: false
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM accoa m
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00024
is: HMDB01206
initial amount: NaN
is: CHEBI:57288
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
name: Acetyl-CoA

metaR S3TASE1ly
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR NDPK8n
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

metaM ksi pre35 g
is: SBO:0000247
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 35
is: CHEBI:28067
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR EX C02470 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Xanthurenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_a68e8c08_1f08_4c69_9d10_5c091414c061
is: SBO:0000252
name: ST3GAL4
is encoded by: hsa:6484
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q6IBE6

http://identifiers.org/biomodels.db/MODEL1310110030#_949aee88_51bf_445f_af49_94539f4ca440
initial amount: NaN
is: Q9BYZ2
constant: false
is: SBO:0000252
name: LDHAL6B
initial concentration: NaN
boundary condition: true
is encoded by: hsa:92483
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_048a3455_1e7e_4132_ab92_d1e0c4852cf0
has only substance units: false
name: UPP1
constant: false
initial concentration: NaN
is encoded by: hsa:7378
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

metaR MERCPLACCYSt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
product: MODEL1310110030#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4915e50b_d501_4f03_a417_eee9a62c8ccf
is encoded by: hsa:57127
initial amount: NaN
constant: false
type: Species
name: RHBG
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9H310
boundary condition: true

metaM o2 x
initial amount: NaN
is: HMDB01377
initial concentration: 1.0
has only substance units: false
is: C00007
name: O2
constant: false
type: Species
is: SBO:0000247
is: CHEBI:15379
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR ORNt3m
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: ornithine mitochondrial transport via proton antiport
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaR r0881
product: MODEL1310110030#
name: Active transport
reversible: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c6adf426_5067_47ec_aa7d_5a9e43bf9c9c
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1738
initial amount: NaN
type: Species
name: DLD
is: SBO:0000252
has only substance units: false
is: P09622

metaM accoa c
boundary condition: false
is: C00024
initial amount: NaN
name: Acetyl-CoA
is: HMDB01206
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM ksii core2 pre1 g
constant: false
has only substance units: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
is: SBO:0000247
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN

metaR GDPtg
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
product: MODEL1310110030#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: GDP intracellular transport
kinetic law: MODEL1310110030#

metaM hs deg21 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
is: CHEBI:16126
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false

metaM lys L e
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:32551
initial concentration: 1.0
is: HMDB00182
name: L-lysinium(1+)
boundary condition: false
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN

metaM pmtcoa r
constant: false
is: HMDB01338
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:3454

metaR CITRtm
is described by: ECO:0000269
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110030#
fast: false
reversible: true
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM dhdascb e
boundary condition: false
constant: false
is: HMDB01264
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
name: dehydroascorbide(1-)
initial concentration: 1.0
is: CHEBI:58070
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d2534183_fa5d_4e96_83e6_4faf7af2afea
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:91734
is: SBO:0000252
name: IDI2
is: Q9BXS1

metaM tetd7ecoa m
is: SBO:0000247
type: Species
is: HMDB13109
initial concentration: 1.0
constant: false
name: 7-tetradecenoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110030#_1c5a85c5_90ac_4888_868b_744a4ce7f5e8
initial amount: NaN
constant: false
boundary condition: true
has part: Q6IB54
is: SBO:0000297
has only substance units: false
type: Species
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522

metaR G14T8g
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8a2edff5_37a7_4cc7_8893_928fdaa806ef
has only substance units: false
name: SLC29A1
initial amount: NaN
initial concentration: NaN
constant: false
is: Q99808
type: Species
is encoded by: hsa:2030
boundary condition: true
is: SBO:0000252

metaM dag hs c
initial amount: NaN
constant: false
is: CHEBI:18035
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r0541
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: true

metaM lys L c
initial amount: NaN
is: CHEBI:32551
initial concentration: 1.0
name: L-lysinium(1+)
constant: false
is: SBO:0000247
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
has only substance units: false

metaM gpail hs c
boundary condition: false
is: CHEBI:17049
constant: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM ade e
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
type: Species
name: adenine
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_7f7e6f65_2e74_4941_964f_4e75b170ad39
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3939
name: LDHA
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P00338

metaR RE1709C
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: RE1709
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_001f2c19_15ef_4784_8f0f_409b4ac88681
is: Q8IW54
name: PDE2A
has only substance units: false
is encoded by: hsa:5138
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaM dhdascb c
is: CHEBI:58070
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
name: dehydroascorbide(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01264
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_8e9dc3fd_a1ec_44d9_ba95_89cd817b09ad
is encoded by: hsa:54
name: ACP5
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: P13686
initial amount: NaN

metaR RETFA
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
reversible: false
name: retinol acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_829f8bb8_32f2_40d5_8ea3_ee6e4b8565ae
is encoded by: hsa:517
is: SBO:0000297
has part: Q06055
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_a3acc957_a34d_406f_9311_fd942c60880f
name: NT5M
is: Q9NPB1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56953
is: SBO:0000252
constant: false

metaR HDCAtr
product: MODEL1310110030#
fast: false
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true

metaM accoa g
name: acetyl-CoA(4-)
has only substance units: false
type: Species
is: CHEBI:57288
constant: false
is: HMDB01206
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM nadph c
is: C00005
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0885
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is: SBO:0000185
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

metaR LINKDEG2ly
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaM phe L e
is: HMDB00159
has only substance units: false
name: L-phenylalanine
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
is: CHEBI:17295

metaM o2 r
is: C00007
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01377
name: O2
type: Species
constant: false

metaM amet m
is: CHEBI:15414
name: S-Adenosyl-L-methionine
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01185
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
constant: false

metaR GULNDer
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
product: MODEL1310110030#
reactant: MODEL1310110030#
name: gulonate dehydrogenase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM CE2433 m
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: C01936
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cc7c54d4_58d4_489d_8cc7_c106dadb90ad
initial amount: NaN
is encoded by: hsa:AL525798
initial concentration: NaN
name: _AL525798_1_c
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR PSDm hs
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.65
name: Phosphatidylserine decarboxylase
type: Reaction
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
fast: false
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_e3341ba5_ec1f_43ab_9bd5_489758515179
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: GGT1
is encoded by: hsa:2678
is: P19440

metaM m1mpdol L c
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110030#_b320eada_68f8_4603_a3a3_f2611df48b37
is encoded by: hsa:2224
initial concentration: NaN
type: Species
is: SBO:0000252
name: FDPS
initial amount: NaN
has only substance units: false
is: P14324
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_dc178a87_60c9_4dfa_a773_2347e72ce535
initial concentration: NaN
is encoded by: hsa:2650
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: Q02742
initial amount: NaN
name: GCNT1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_3d34c1b6_d649_4ae4_98a1_d162cf76673a
initial concentration: NaN
type: Species
is: SBO:0000252
is: O43677
name: NDUFC1
boundary condition: true
is encoded by: hsa:4717
constant: false
initial amount: NaN
has only substance units: false

metaR GCC2cm
is: SBO:0000176
fast: false
reversible: true
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6be96968_24ea_48ef_99a9_45ca90219e16
is: O43772
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC25A20
constant: false
is encoded by: hsa:788
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_ff62989a_0685_443e_b6b6_ed2b1eabba58
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: P25705
initial amount: NaN
constant: false
is encoded by: hsa:498
name: ATP5A1
is: SBO:0000252

metaM pmtcoa m
is: C00154
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01338
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_ab8fc196_e68f_4809_ad23_80f5d2e03174
initial concentration: NaN
boundary condition: true
is encoded by: hsa:115019
name: SLC26A9
initial amount: NaN
is: Q7LBE3
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_81423d4a_c6e1_4785_a914_17e66758e6c2
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: HAS1
is encoded by: hsa:3036
is: SBO:0000252
is: Q8IYH3
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_1c286591_cd9d_4546_a83f_57e6a13d8423
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1340
type: Species
is: SBO:0000252
initial concentration: NaN
is: P14854
constant: false
name: COX6B1

metaR FACOAL170
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_7f2be133_6489_4f02_af21_bc1b2e839604
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:10164
is: Q8NCG5
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: CHST4

metaM phe L c
is: SBO:0000247
constant: false
name: L-phenylalanine
is: CHEBI:17295
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00159
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false

metaR r1920
name: Y+LAT2 Utilized transport
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110030#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0eca0785_346f_4fb2_8752_941d2abe02a4
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: A6NDW6
is encoded by: hsa:79053
name: ALG8

http://identifiers.org/biomodels.db/MODEL1310110030#_a714aa9d_0b93_43ad_83bd_1854e558c6e3
name: PIGX
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q8TBF5
initial concentration: NaN
constant: false
is encoded by: hsa:54965

metaM pd3 c
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06500
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
has only substance units: false
name: Previtamin D3

http://identifiers.org/biomodels.db/MODEL1310110030#_2a75852d_4d8d_4316_ad17_3a7ed85ad145
name: SLC24A4
has only substance units: false
is: Q8NFF2
type: Species
is encoded by: hsa:123041
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_62f15c53_45f2_4f81_be33_17247e7d861d
is encoded by: hsa:158
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: ADSL
is: P30566

http://identifiers.org/biomodels.db/MODEL1310110030#_0c40408d_f9e1_4f81_93b1_e211c5269b91
type: Species
is encoded by: hsa:AA576959
has only substance units: false
is: SBO:0000252
name: _AA576959_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM cs a deg1 l
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16953
type: Species
is: HMDB00812
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_99e00851_0860_418d_9fae_ef24e28b279d
initial amount: NaN
is encoded by: hsa:6785
name: ELOVL4
constant: false
is: Q9GZR5
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_9d9ef7c5_d8e7_44b8_8d90_5408ce25c7d3
initial concentration: NaN
name: DDOST
is encoded by: hsa:1650
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: P39656
has only substance units: false
is: SBO:0000252

metaR FATP1t
modifier: MODEL1310110030#
name: fatty acid electroneutral transport
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
reactant: MODEL1310110030#
fast: false

metaR r0954
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: MCT 1 Transport reaction
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_90034e56_8396_4e14_b773_d4a915230948
constant: false
is: O75355
boundary condition: true
is: SBO:0000252
name: ENTPD3
has only substance units: false
initial amount: NaN
is encoded by: hsa:956
type: Species
initial concentration: NaN

metaR r0653
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reversible: false
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110030#

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR ASNNm
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.1.1
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
reversible: false
product: MODEL1310110030#
is described by: ECO:0000254
name: L-asparaginase (mitochondrial)
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_dfde4baa_f5d7_4a87_9e1d_39a599d4890c
is encoded by: hsa:23563
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: CHST5
initial concentration: NaN

metaM glu5p m
is: SBO:0000247
has only substance units: false
is: CHEBI:58274
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01228
constant: false
boundary condition: false
name: L-Glutamate 5-phosphate
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287

http://identifiers.org/biomodels.db/MODEL1310110030#_d30f375d_edef_4cb2_9877_e8065ea96323
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: P34896
is encoded by: hsa:6470
constant: false
initial concentration: NaN
name: SHMT1

http://identifiers.org/biomodels.db/MODEL1310110030#_8c65ff6d_4a28_46a8_9254_bd37a2d1b067
is encoded by: hsa:5730
type: Species
name: PTGDS
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: P41222
initial concentration: NaN
constant: false

metaM retn r
has only substance units: false
is: SBO:0000247
is: HMDB01852
boundary condition: false
name: all-trans-retinoate
initial amount: NaN
type: Species
is: CHEBI:35291
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false

metaR F1PGT
fast: false
reactant: MODEL1310110030#
name: fucose-1-phosphate guanylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.30
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#

metaR C141OHc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_556fcd34_ba7e_4ad1_9ede_15807a050832
initial concentration: NaN
is: SBO:0000252
type: Species
name: NDUFA12
initial amount: NaN
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_4e0a9a4f_6341_468d_8f08_b7a530638f03
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI640625
initial concentration: NaN
boundary condition: true
name: _AI640625_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2cd598c3_fc6b_47bc_852d_bce0d5d3c367
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152
boundary condition: true
has only substance units: false
type: Species
name: PDE9A

metaM lys L m
constant: false
initial concentration: 1.0
is: CHEBI:32551
type: Species
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: L-lysinium(1+)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1da35135_4ac9_43b4_bd33_e1f02c238fe9
is: SBO:0000252
initial concentration: NaN
name: SKIV2L2
constant: false
boundary condition: true
is: Q3MHC9
initial amount: NaN
is encoded by: hsa:23517
has only substance units: false
type: Species

metaR SARCStm
is described by: ECO:0000000
name: Sarcosine transport (mitochondrial)
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_ffbb757d_dca1_46b0_9106_52f7f7ace9c7
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:30
type: Species
is: Q96CA6
name: ACAA1
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR GALt4
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110030#
fast: false
reversible: true
modifier: MODEL1310110030#
name: galactose transport via sodium symport
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000269

metaR GLCNACASE5ly
kinetic law: MODEL1310110030#
reversible: false
fast: false
modifier: MODEL1310110030#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_0aa8c3c5_b539_4306_b961_bedca0462d83
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: LIPA
is encoded by: hsa:3988
initial amount: NaN
constant: false
is: P38571
initial concentration: NaN

metaR CMPACNAtn
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: CMP-Sia nuclear export
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
type: Reaction

metaR EX CE5791 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 4-8 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3fbe4786_b0a2_4abf_939b_5f0e3800ded0
is encoded by: hsa:6389
initial concentration: NaN
name: SDHA
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: P31040

http://identifiers.org/biomodels.db/MODEL1310110030#_80d35072_09bf_4279_b553_752601499341
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2597
is: E7EUT4
boundary condition: true
name: GAPDH
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_76dbd919_8203_4944_b05c_1735d7e0f9cf
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q86YU0
name: CA7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:766

metaR RE1804M
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: true
name: RE1804

http://identifiers.org/biomodels.db/MODEL1310110030#_604a86cb_57fc_43ae_9e79_8ac6ac127bbd
is encoded by: hsa:84701
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: COX4I2
boundary condition: true
is: Q96KJ9

metaR LCYSTCBOXL
is version of: http://identifiers.org/ec-code/4.1.1.29
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: 3-Sulfoalanine carboxy-lyase
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110030#_79c65aeb_0760_4554_aa16_ed5c0c5bbc36
boundary condition: true
initial amount: NaN
has only substance units: false
is: A1L4Q0
is encoded by: hsa:8526
constant: false
initial concentration: NaN
is: SBO:0000252
name: DGKE
type: Species

metaM amet c
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: C00019
is: HMDB01185
name: S-Adenosyl-L-methionine
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_692c8b0a_ea4d_40af_9ccb_8e0ad79f1553
type: Species
boundary condition: true
is: P35754
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2745
constant: false
has only substance units: false
name: GLRX

metaR C141OHe
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR THRGLNexR
name: L-threonine/glycine reversible exchange
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110030#
is described by: ECO:0000304

metaR UAGDP
is version of: http://identifiers.org/ec-code/2.7.7.23
name: UDP-N-acetylglucosamine diphosphorylase
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_00388352_7286_4d0b_9973_5ac499cf5620
type: Species
name: OCRL
constant: false
is encoded by: hsa:4952
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: D-4'-Phosphopantothenate
type: Species
is: CHEBI:10986
constant: false
is: HMDB01016
is: C03492
initial amount: NaN
has only substance units: false

metaM pmtcoa x
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
initial concentration: 1.0
is: CHEBI:57379
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: C00154
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_eef2dbe2_43b3_4497_9f64_b1e2e0fc7cc8
is encoded by: hsa:55312
name: RFK
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: B2RDZ2
initial concentration: NaN
has only substance units: false
type: Species

metaR FAOXC161C141m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_060a41ca_9a9a_4c64_88ac_3aff5ca33df7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:196883
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q8NFM4
type: Species
name: ADCY4

metaR NADtx
product: MODEL1310110030#
type: Reaction
name: transport of NAD into peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110030#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110030#

metaR r1929
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM CE5786 e
boundary condition: false
is: CHEBI:27485
name: kinetensin
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB02710
constant: false
is: SBO:0000247

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM ksii core4 pre7 g
initial concentration: 1.0
is: CHEBI:58053
type: Species
is: C00130
is: SBO:0000247
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: HMDB00175
boundary condition: false

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
name: Choline kinase
product: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
kinetic law: MODEL1310110030#

metaM f6p c
name: D-Fructose 6-phosphate
boundary condition: false
is: http://identifiers.org/pubchem.compound/3385
initial amount: NaN
type: Species
is: HMDB00124
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57579
is: C00085
initial concentration: 1.0

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: RE1709
fast: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_91ca5fb2_313e_40a1_8347_311be5ca6892
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: SHMT2
initial amount: NaN
is: B4DJQ3
is encoded by: hsa:6472
type: Species

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7da391e1_532b_4865_9bdd_fa5a20ee979c
name: AK2
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:204
is: SBO:0000252

metaM c226coa x
is: SBO:0000247
boundary condition: false
constant: false
is: C16169
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110030#_3437a84f_aa1f_4c44_9078_276424b2523b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8604
initial amount: NaN
boundary condition: true
is: O75746
type: Species
constant: false
name: SLC25A12

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
product: MODEL1310110030#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_cecccaf0_baa5_416c_9047_6161a9344c37
is encoded by: hsa:2629
initial amount: NaN
is: B7Z6S1
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: GBA

metaR GLYSNAT5tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR PEt
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_beb71e43_2482_49e3_9e94_0e3af3edcfe9
boundary condition: true
is: Q13907
initial amount: NaN
name: IDI1
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:3422
has only substance units: false

metaR RE1516M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110030#
reversible: true

metaR HBZOPT10m
is version of: http://identifiers.org/ec-code/2.5.1.39
product: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
name: Hydroxybenzoate Decaprenyltransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
kinetic law: MODEL1310110030#
type: Reaction
reversible: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d59ec349_4439_4e63_9e9a_3677ce12a091
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM naglc2p L c
initial concentration: 1.0
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
is: CHEBI:18278
is: SBO:0000247
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR G6PDA
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.99.6
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
name: glucosamine-6-phosphate deaminase
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: false

metaR FACOAL180i
fast: false
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000269
name: C180 fatty acid activation
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR r0651
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_1e9b28b6_f3ff_40ca_91d2_83f6cf725ba4
is encoded by: hsa:6567
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC16A2
is: P36021
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
fast: false
product: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR ALACYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110030#

metaR COQ5m
fast: false
reversible: false
is: SBO:0000176
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT

metaM alpa hs c
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: lysophosphatidic acid
constant: false
type: Species
has only substance units: false
is: CHEBI:52288
boundary condition: false

metaR ASNTHRNaEx
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#

metaM ala B c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00056
name: beta-alanine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaM ksi deg33 l
is: HMDB00143
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 33
has only substance units: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: CHEBI:12936
type: Species
constant: false

metaR UAG2EMAi
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110030#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110030#

metaR r1928
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR r2519
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Utilized transport
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
product: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_6dc8758f_dd71_4541_a541_de58b35477ff
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:27068
boundary condition: true
name: PPA2

metaR r0650
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110030#
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR r0424
type: Reaction
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_16d3d527_b9a0_4be6_9cd6_6dc4d9f1a36a
has only substance units: false
is: SBO:0000252
is: Q9BZ23
boundary condition: true
is encoded by: hsa:80025
name: PANK2
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_962a8ceb_ede6_4948_8022_73ffdf004a90
initial amount: NaN
constant: false
is encoded by: hsa:5313
is: P30613
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PKLR
has only substance units: false
type: Species

metaR LINKDEG1ly
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110030#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#

metaM gd3 hs g
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28424
name: GD3
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_bddc2b5a_7080_4c4f_b12f_6bd281fe11ba
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:29925
initial concentration: NaN
name: GMPPB
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_f7344083_78a8_4aec_9370_4f051410fb59
boundary condition: true
constant: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
is: SBO:0000297
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d534120c_9b05_46d4_a30d_0b482c21dfa4
name: GALC
initial amount: NaN
is encoded by: hsa:2581
is: P54803
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cac90329_1cad_4914_907c_de9cf25ce0cc
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5372
boundary condition: true
is: A8K003
name: PMM1
is: SBO:0000252
has only substance units: false

metaM gly c
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: Glycine
is: HMDB00123
is: C00037
is: SBO:0000247
constant: false
is: CHEBI:3339
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fdd5d3b0_099a_43b5_8e46_a83d547e23f8
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5052
has only substance units: false
boundary condition: true
name: PRDX1
constant: false

metaR r1908
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: false

metaR DOPAtu
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
name: Dopamine uniport
reactant: MODEL1310110030#

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial concentration: 1.0
type: Species
is: SBO:0000247
name: diglyceride
constant: false
boundary condition: false
is: CHEBI:18035
has only substance units: false
initial amount: NaN

metaM fadh2 c
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
initial amount: NaN
type: Species
initial concentration: 1.0
name: FADH2(2-)
boundary condition: false

metaR GLU5Km
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000254
name: glutamate 5-kinase (m)
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.41

metaR MCPST
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
is version of: http://identifiers.org/ec-code/2.8.1.2
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
name: 3-mercaptopyruvate sulfurtransferase
reversible: false
is: SBO:0000176
is described by: ECO:0000134

metaM dump c
is: CHEBI:246422
is: C00365
is: HMDB01409
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
type: Species
is: SBO:0000247

metaR CSPG Atly
is: SBO:0000185
name: chondroitin sulfate A transport, extracellular to lysosome
product: MODEL1310110030#
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_1c195bf5_c615_4ac1_b74a_17c97c66319b
constant: false
initial concentration: NaN
type: Species
is: Q7L266
has only substance units: false
name: ASRGL1
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:80150

metaR r0423
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
type: Reaction

metaM dudp c
is: C01346
type: Species
has only substance units: false
constant: false
boundary condition: false
name: dUDP
initial amount: NaN
is: CHEBI:60471
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
is: SBO:0000247

metaR NADHtpu
reversible: false
reactant: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
name: NADH transporter, peroxisome
fast: false
is described by: ECO:0000000

metaM L2aadp c
name: L-2-aminoadipate(1-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: CHEBI:58672
is: SBO:0000247
is: HMDB00510
constant: false
type: Species

metaR ST8SIA11
type: Reaction
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.99.8
product: MODEL1310110030#

metaR MG3er
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110030#
type: Reaction
is: SBO:0000176

metaM dutp m
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: CHEBI:17625
is: HMDB01191
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM gly e
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Glycine
is: HMDB00123
is: C00037
is: SBO:0000247
constant: false
is: CHEBI:3339
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_a18ccb8f_9968_49a3_8094_73d9b6dbd876
is: SBO:0000252
initial amount: NaN
is: P04066
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2517
initial concentration: NaN
name: FUCA1
has only substance units: false

metaM HC02180 c
initial amount: NaN
has only substance units: false
type: Species
name: thromboxane-b2
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
is: CHEBI:28728
is: SBO:0000247

metaR LTD4DP
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: Leukotriene D4 dipeptidase
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_31ad4a88_2302_4770_999d_715b3697451c
type: Species
initial concentration: NaN
constant: false
name: ATP5E
has only substance units: false
boundary condition: true
is encoded by: hsa:514
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_56e16709_70aa_489e_8355_bcf2fdac739b
constant: false
boundary condition: true
type: Species
has only substance units: false
name: NDUFS1
is: P28331
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4719

metaM dutp n
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01191
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
name: dUTP

metaR KHte
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
name: KHte
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110030#_a3c7977b_dec0_43a8_8bcc_e2bba25217bc
is encoded by: hsa:6391
constant: false
initial amount: NaN
name: SDHC
has only substance units: false
initial concentration: NaN
is: Q99643
is: SBO:0000252
boundary condition: true
type: Species

metaR S6TASE17ly
reversible: true
modifier: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction

metaM gar c
is: HMDB02022
is: SBO:0000247
boundary condition: false
is: CHEBI:58457
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: C03838
initial amount: NaN
name: N1-(5-Phospho-D-ribosyl)glycinamide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a602d354_4c84_4216_a77d_e5275db18874
constant: false
is: SBO:0000252
name: BCAT1
type: Species
initial concentration: NaN
is encoded by: hsa:586
initial amount: NaN
is: P54687
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_106a02c1_b4e0_4e45_9137_cfbe5f2f62f9
is: SBO:0000252
name: ST8SIA1
is encoded by: hsa:6489
boundary condition: true
is: Q92185
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR CHSTEROLt1
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000304
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: cholesterol intracellular transport
modifier: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

metaR r0647
reactant: MODEL1310110030#
name: Spontaneous reaction
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_429ea3ea_59fd_497e_b853_8fff6a918453
name: GALNT2
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:2590
is: SBO:0000252
is: Q10471

http://identifiers.org/biomodels.db/MODEL1310110030#_b0d15258_1af1_47d9_b199_00ec0f5a054d
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
name: _AI620219_1_m
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR AG13T9g
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:58439
is: SBO:0000247
name: UDP-D-galactose(2-)
initial amount: NaN
is: HMDB00302
initial concentration: 1.0

metaM oaa m
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
boundary condition: false
name: Oxaloacetate
type: Species
is: C00036
initial amount: NaN
is: HMDB00223
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR G12MT2 L
fast: false
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_205dce49_2afc_4aa4_b0e7_fb40a3792adc
type: Species
name: ALDH3A1
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P30838
is encoded by: hsa:218

metaM gtp c
type: Species
initial amount: NaN
constant: false
is: CHEBI:37565
boundary condition: false
is: C00044
has only substance units: false
name: GTP
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
initial concentration: 1.0

metaM o2 e
is: CHEBI:15379
has only substance units: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00007
is: HMDB01377
name: O2
constant: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM 5dpmev x
constant: false
initial concentration: 1.0
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
is: SBO:0000247
is: HMDB01090
boundary condition: false
is: CHEBI:15899
has only substance units: false
initial amount: NaN

metaR r0644
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
reversible: true
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaM udpg r
boundary condition: false
has only substance units: false
is: HMDB00286
is: SBO:0000247
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
initial concentration: 1.0
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367

metaM HC02180 e
constant: false
type: Species
name: thromboxane-b2
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial amount: NaN

metaR CHSTEROLt2
is: SBO:0000185
kinetic law: MODEL1310110030#
name: cholesterol intracellular transport
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
reversible: true
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaR r2525
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_8a59ac0a_d030_4eb6_8f1a_f8a16a5e3ed0
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:93034
constant: false
is: B3KUK6
name: NT5C1B
initial concentration: NaN

metaR URIt5le
reactant: MODEL1310110030#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110030#
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

metaR CMPACNAtg
product: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
type: Reaction
fast: false
name: CMP-Sia Golgi transport via CMP antiport
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
kinetic law: MODEL1310110030#
is described by: ECO:0000269

metaR FAOXC12C10m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaM mag hs c
type: Species
boundary condition: false
name: monoacylglycerol 2
is: SBO:0000247
is: CHEBI:16987
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: HMDB12130
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR CHSTEROLt3
reactant: MODEL1310110030#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
name: cholesterol intracellular transport
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR r2526
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_bd394e7a_7b3b_4be7_a7ba_eed9e53adc42
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: SLC25A15
is: Q9Y619
is encoded by: hsa:10166
initial amount: NaN
is: SBO:0000252

metaM CE4872 c
is: CHEBI:15748
constant: false
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species
has only substance units: false
is: SBO:0000247

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)

metaR CRNCAR3tp
product: MODEL1310110030#
name: carnitine-propcarnitine carrier, peroxisomal
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reversible: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM o2 c
is: CHEBI:15379
constant: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
boundary condition: false
name: O2
initial amount: NaN
is: C00007
is: SBO:0000247
is: HMDB01377
has only substance units: false

metaM retinal c
has only substance units: false
is: SBO:0000247
boundary condition: false
name: retinal
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
is: HMDB01358
type: Species

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_12e61c7c_6f97_41ca_b1a1_d68e074fbaeb
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9498
is: E7EML0
name: SLC4A8
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR ORNDC
name: Ornithine Decarboxylase
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is version of: http://identifiers.org/ec-code/4.1.1.17
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#

metaR r0311
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
type: Reaction
reversible: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110030#_f434dbaa_2a68_4822_8270_80f62548e764
name: SLC17A4
constant: false
is: Q9Y2C5
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10050
is: SBO:0000252
type: Species

metaM ksi deg38 l
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:12936
type: Species
is: HMDB00143
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 38

http://identifiers.org/biomodels.db/MODEL1310110030#_774f8604_5e90_43df_90a0_72a03e55b5f8
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ST3GAL3
has only substance units: false
is encoded by: hsa:6487
initial concentration: NaN

metaR r0899
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: Amino acid transporter ATB0+ Facilitated diffusion

metaR PROSTGI2tr
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
name: Prostaglandin I2 transport (ER)
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
reversible: true

metaR GDPFUCtg
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
name: GDPFuc Golgi transport via CMP antiport
is: SBO:0000185

metaM 3oddcoa m
is: CHEBI:27868
type: Species
constant: false
name: 3-Oxododecanoyl-CoA
is: HMDB03937
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial concentration: 1.0
boundary condition: false

metaM dudp m
is: CHEBI:60471
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: HMDB01000
has only substance units: false
name: dUDP(3-)

metaR GPIMTer U
fast: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
reversible: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD

metaM udpgal g
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00302
is: CHEBI:58439
boundary condition: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fa1b8754_0934_4bee_ae02_7b73a780af8c
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4728
boundary condition: true
constant: false
initial concentration: NaN
is: O00217
name: NDUFS8

metaM CE4872 m
has only substance units: false
constant: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

metaM c226coa m
is: http://identifiers.org/pubchem.compound/47205479
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
initial amount: NaN
is: C16169
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaM CE2424 m
constant: false
is: HMDB11123
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: CHEBI:28387
boundary condition: false

metaR r2520
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
kinetic law: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM trdox c
constant: false
is: C00343
initial amount: NaN
is: CHEBI:18191
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
is: SBO:0000247
has only substance units: false

metaM mag hs e
initial amount: NaN
type: Species
initial concentration: 1.0
name: monoacylglycerol 2
is: CHEBI:60479
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e5bc2466_2c60_4f61_808b_a09135558ec3
initial amount: NaN
name: SLC4A2
is: SBO:0000252
is encoded by: hsa:6522
initial concentration: NaN
is: F8W682
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR G14T13g
modifier: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2d81f328_e7fd_4aa4_9554_8cc762b0ae88
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: P30038
name: ALDH4A1
is encoded by: hsa:8659
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_3ba592cf_2fde_4ed9_a3aa_a248990f2c06
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6718
is: SBO:0000252
name: AKR1D1
type: Species
is: P51857
initial concentration: NaN
constant: false

metaM tridcoa m
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
name: tridecanoylcoa
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB13109

metaR 3MOBt2im
reversible: false
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_469f38ff_6819_419e_af76_c9a7b9a05cc0
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O95822
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:23417
boundary condition: true
name: MLYCD

metaR r1156
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110030#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is described by: ECO:0000000

metaM dutp c
is: HMDB01191
name: dUTP
boundary condition: false
is: CHEBI:17625
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
is: SBO:0000247
type: Species
is: C00460

metaR r0202
product: MODEL1310110030#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110030#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

metaR r2521
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is described by: ECO:0000000
name: Utilized transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction

metaR UMPK6n
reactant: MODEL1310110030#
name: UMP kinase (dCTP),nuclear
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR PPItr
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_406289ef_b152_4d59_9e38_f7aa0d631d92
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q9BQG2
boundary condition: true
is encoded by: hsa:83594
name: NUDT12
initial amount: NaN

metaM clpndcoa c
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: HMDB06267
is: http://identifiers.org/pubchem.compound/47205476
is: SBO:0000247
type: Species
has only substance units: false
name: clupanodonyl CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C16166

metaR RE3628M
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000000
name: RE3628
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_815947f6_28d8_4d17_8e0c_da0f01668ced
is: SBO:0000252
is encoded by: hsa:43
boundary condition: true
constant: false
initial concentration: NaN
name: ACHE
has only substance units: false
initial amount: NaN
type: Species

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM ser D e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03406
name: D-serine
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaR r1154
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
name: EC:1.2.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction

metaR UGCG
is version of: http://identifiers.org/ec-code/2.4.1.80
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
name: Ceramide glucosyltransferase
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000000
fast: false

metaR ST8SIA12
reversible: false
modifier: MODEL1310110030#
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110030#
type: Reaction

metaR GALASE19ly
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_c1b5ae1b_d97f_4b93_b081_6dd13ea1a7dd
name: DCTD
is: P32321
constant: false
boundary condition: true
is encoded by: hsa:1635
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaR EX xoltri24 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7-alpha,24(S)-Dihydroxycholesterol exchange
type: Reaction

metaM dhap e
type: Species
initial concentration: 1.0
name: glycerone phosphate(2-)
constant: false
initial amount: NaN
is: CHEBI:57642
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
has only substance units: false
boundary condition: false

metaR CORE4GTg
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.102
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cd65f632_824a_4db9_8fe8_f5a40a612e1a
initial amount: NaN
is encoded by: hsa:11343
boundary condition: true
has only substance units: false
constant: false
name: MGLL
is: Q99685
type: Species
initial concentration: NaN
is: SBO:0000252

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM dttp m
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: SBO:0000247
is: CHEBI:37568
is: C00459
type: Species
initial concentration: 1.0
is: HMDB01342
name: dTTP
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_bf174cd4_0ac1_4225_9094_71d7a53263c8
type: Species
is encoded by: hsa:AI990637
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: _AI990637_1_x
boundary condition: true

metaR PPItm
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
fast: false

metaM dttp n
boundary condition: false
name: dTTP
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: CHEBI:37568
type: Species
constant: false
is: HMDB01342
is: C00459

metaM o2 m
name: O2
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: CHEBI:15379
initial amount: NaN
is: HMDB01377
boundary condition: false
has only substance units: false
is: C00007
type: Species
is: SBO:0000247

metaR TXA2tr
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
type: Reaction
name: thromboxane A2 intracellular transport
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_df1df875_053a_49b0_a805_cae84fef4836
initial concentration: NaN
is: O43511
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: SLC26A4
is encoded by: hsa:5172
type: Species
boundary condition: true

metaR GLCURter
name: glucuronate endoplasmic reticular transport
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#

metaM 5fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
constant: false
is: HMDB01562
is: CHEBI:57457
type: Species

metaM dudp n
is: HMDB01000
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
is: CHEBI:60471
has only substance units: false
name: dUDP(3-)
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_d954a352_6039_45d9_bd04_31873c0cde5d
type: Species
is encoded by: hsa:51227
boundary condition: true
is encoded by: hsa:5279
constant: false
has part: B2RAU6
has only substance units: false
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
has part: P57054
is encoded by: hsa:5277
initial concentration: NaN
initial amount: NaN

metaR L LACt4r
is described by: ECO:0000000
fast: false
type: Reaction
name: L-lactate reversible transport via sodium symport
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:

metaR RE1448N
fast: false
name: RE1448
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9dca87ef_b6c5_4824_a703_805a1bc063f3
initial amount: NaN
is encoded by: hsa:1841
name: DTYMK
constant: false
is: P23919
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR NAIt
kinetic law: MODEL1310110030#
fast: false
type: Reaction
modifier: MODEL1310110030#
name: Na+ / iodide cotransport
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_219c562d_c32c_4443_bdcf_142e4a6889ae
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: SLC24A4
initial concentration: NaN
is encoded by: hsa:123041

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM ksii core4 pre6 g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
constant: false
name: keratan sulfate II biosynthesis, precursor 6
is: SBO:0000247
type: Species
is: CHEBI:28067

metaR r0539
type: Reaction
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#

metaM dhap c
type: Species
initial concentration: 1.0
is: C00111
constant: false
is: CHEBI:57642
name: Dihydroxyacetone phosphate
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
is: HMDB01473

metaR C12OHc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_34f868ce_bece_460e_aa1e_d3525fd6de88
initial concentration: NaN
constant: false
is: SBO:0000297
type: Species
is encoded by: hsa:8818
has only substance units: false
has part: Q9P2X0
is encoded by: hsa:54344
boundary condition: true
name: DPM3:DPM1:DPM2
initial amount: NaN

metaR DOLPGT2 Ler
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110030#
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)

http://identifiers.org/biomodels.db/MODEL1310110030#_0cdadffd_e7dd_45ff_9adc_8f1233853192
initial concentration: NaN
is: SBO:0000252
is: O75947
initial amount: NaN
name: ATP5H
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10476

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_23190f16_67dd_499c_a0d7_69150cbf9f9f
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5334
name: PLCL1
initial concentration: NaN
is: Q15111

metaM ksi pre20 g
type: Species
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 20
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_fcd3a13f_d059_4843_a08e_79837103070e
is: P82251
initial amount: NaN
boundary condition: true
type: Species
name: SLC7A9
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11136

metaR CYSGLNNaEx
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
fast: false
type: Reaction
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#

metaM cholcoads x
is: HMDB06889
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27505
constant: false
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460

metaR MALSO3tm
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfite antiport, mitochondrial
reversible: true
modifier: MODEL1310110030#

metaM oaa c
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
is: CHEBI:3338
boundary condition: false
name: Oxaloacetate
is: SBO:0000247
is: HMDB00223
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: C00036

metaR NDPK9n
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_8df38bc2_6177_4ec4_bf93_45871c7850d6
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4512
name: COX1
type: Species
has only substance units: false
is: SBO:0000252
is: Q7GXY8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_9caef644_0b75_497d_b70c_1916fe4c9216
constant: false
is encoded by: hsa:3157
initial amount: NaN
is: Q01581
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: HMGCS1

metaM CE5791 e
is: CHEBI:27485
type: Species
name: kinetensin 4-8
boundary condition: false
initial concentration: 1.0
is: HMDB02710
has only substance units: false
notes: FORMULA: C35H47N10O7 CHARGE: 1 INCHI: InChI=1/C35H46N10O7/c36-25(8-4-14-40-35(37)38)30(47)43-27(18-23-19-39-20-41-23)33(50)45-15-5-9-29(45)32(49)42-26(16-22-10-12-24(46)13-11-22)31(48)44-28(34(51)52)17-21-6-2-1-3-7-21/h1-3,6-7,10-13,19-20,25-29,46H,4-5,8-9,14-18,36H2,(H,39,41)(H,42,49)(H,43,47)(H,44,48)(H,51,52)(H4,37,38,40)/p+1/t25-,26-,27+,28+,29+/m1/s1 EHMN_ABBREVIATION: CE5791
initial amount: NaN
is: SBO:0000247
constant: false

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00211
name: myo-inositol

http://identifiers.org/biomodels.db/MODEL1310110030#_c5534027_e72b_44ce_842b_fddc74a95ac2
type: Species
is: Q6IBB5
has only substance units: false
is encoded by: hsa:4694
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: NDUFA1
boundary condition: true

metaM clpndcoa x
is: HMDB06267
constant: false
has only substance units: false
is: C16166
is: http://identifiers.org/pubchem.compound/47205476
type: Species
name: clupanodonyl CoA
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_ee8b23b2_ac6b_48fd_bc56_3fe64e1c158f
is encoded by: hsa:8654
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: PDE5A

metaR M8MASNterg
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
fast: false
name: m8masn transport from ER to Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaR r0208
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is version of: http://identifiers.org/ec-code/4.4.1.1
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_7b1bb386_f8e0_43af_be8e_af8f6a8d3bef
boundary condition: true
is encoded by: hsa:2618
initial concentration: NaN
has only substance units: false
type: Species
is: Q59HH3
name: GART
is: SBO:0000252
constant: false
initial amount: NaN

metaM orot e
constant: false
initial amount: NaN
is: HMDB00226
is: SBO:0000247
is: CHEBI:30839
name: orotate
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_018fb4ae_006e_4431_821e_1d19a4461ad3
name: LDHC
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3948
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaM gdpfuc g
is: SBO:0000247
is: HMDB01095
name: GDP-L-fucose(2-)
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57984

metaM gtp n
is: HMDB01273
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM 4abut m
initial amount: NaN
is: SBO:0000247
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
boundary condition: false
constant: false
is: C00334
initial concentration: 1.0
is: CHEBI:16865
name: 4-Aminobutanoate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_1bfeaf85_bc36_4805_8c09_d259258ab639
initial concentration: NaN
is: Q86YT5
type: Species
is: SBO:0000252
name: SLC13A5
constant: false
initial amount: NaN
is encoded by: hsa:284111
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8779b3e5_add0_4843_bbed_548874416557
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q6UWQ5
has only substance units: false
name: LYZL1
is encoded by: hsa:84569
initial amount: NaN

metaM pa hs c
is: SBO:0000247
name: phosphatidate(2-)
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_2c4363ac_0605_4bad_b63c_b34a50c17c36
type: Species
constant: false
name: UPP1
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q16831
is encoded by: hsa:7378
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_16b2e66b_781f_4151_86b3_e3cb91d52159
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:55350
constant: false
initial concentration: NaN
boundary condition: true
name: VNN3

metaR CYTK10
is described by: ECO:0000269
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110030#
name: cytidylate kinase (CMP,dGTP)

metaR FOLR2
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254
product: MODEL1310110030#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110030#

metaR DHPM1
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
is version of: http://identifiers.org/ec-code/3.5.2.2
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
type: Reaction
fast: false
reversible: false

metaM inost c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
has only substance units: false
is: CHEBI:17268
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: myo-inositol
is: SBO:0000247

metaR G14T7g
fast: false
reversible: false
modifier: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR r0317
modifier: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR THRASNNaEx
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
type: Reaction

metaR ALDD2xm
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000134
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_b6204019_5500_43b0_8d47_dfed1307c645
has only substance units: false
constant: false
is: Q9H6R3
is encoded by: hsa:79611
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: ACSS3
initial concentration: NaN

metaR CYTK11
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110030#
name: cytidylate kinase (dCMP,dGTP)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_c5f082d6_f2db_4f7b_9033_48be5e68af7b
is: Q8IWX5
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:130367
initial amount: NaN
name: SGPP2
has only substance units: false
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_aedc8f91_5e2d_4acc_b372_86a55d824c15
initial amount: NaN
is: Q96NT5
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:113235
is: SBO:0000252
initial concentration: NaN
name: SLC46A1

metaM orot c
is: C00295
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00226
is: SBO:0000247
is: CHEBI:30839
initial concentration: 1.0
type: Species
name: Orotate

http://identifiers.org/biomodels.db/MODEL1310110030#_1509a7c6_1907_4b67_beba_9a8db8e13e93
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI222095
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: _AI222095_1_e

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaM c226coa c
is: C16169
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_4bef0987_d23e_43f6_8148_1c35eaa85030
boundary condition: true
is encoded by: hsa:1892
is: P30084
has only substance units: false
initial amount: NaN
type: Species
name: ECHS1
is: SBO:0000252
initial concentration: NaN
constant: false

metaR ACACtx
reactant: MODEL1310110030#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
name: acetoacetate intracellular transport unknown mechanism
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
product: MODEL1310110030#

metaM mescon m
constant: false
initial concentration: 1.0
is: HMDB00749
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:36986
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate

metaR RE1845C
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110030#
name: RE1845
fast: false

metaM T antigen g
boundary condition: false
name: T antigen (core 1)
notes: FORMULA: C14H24NO10X CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:22783
type: Species

metaM ser D c
is: SBO:0000247
is: HMDB03406
boundary condition: false
initial amount: NaN
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110030#_2e8156d6_1afd_4a37_b3ab_0717ad6b20b9
constant: false
initial concentration: NaN
is: Q07326
type: Species
name: PIGF
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5281
initial amount: NaN
boundary condition: true

metaM gly x
is: SBO:0000247
has only substance units: false
type: Species
name: glycine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
initial amount: NaN
is: HMDB00123
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_ee73c036_411f_4668_aa39_4ed5ffc44ce2
initial concentration: NaN
has only substance units: false
type: Species
is: Q12882
constant: false
initial amount: NaN
name: DPYD
boundary condition: true
is encoded by: hsa:1806
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_100f99f3_5b11_400a_a7ff_2b48b73511dd
is encoded by: hsa:51166
type: Species
has only substance units: false
is: Q8N5Z0
constant: false
is: SBO:0000252
initial concentration: NaN
name: AADAT
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_1f54bcc4_e468_406b_a7f3_fd1f9194a916
initial amount: NaN
boundary condition: true
is encoded by: hsa:1716
initial concentration: NaN
constant: false
name: DGUOK
has only substance units: false
is: SBO:0000252
type: Species

metaM dttp e
is: SBO:0000247
name: dTTP(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
is: CHEBI:37568
is: HMDB01342
initial concentration: 1.0
constant: false

metaM dhcholestanate c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16577
is: HMDB00359
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaR ACGAMtly
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: N-acetyl-glucosamine lysosomal efflux

metaM cgly c
initial amount: NaN
constant: false
is: HMDB00078
is: CHEBI:4047
is: SBO:0000247
name: L-cysteinylglycine
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaM dump n
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
name: dUMP(2-)
type: Species
is: HMDB01409
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR NCAMUP
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
fast: false
name: Nicotinamide acid uptake
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is: SBO:0000185
product: MODEL1310110030#

metaR DTMPK
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110030#
name: dTMP kinase
reversible: true
fast: false

metaM fadh2 m
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: C01352
name: Flavin adenine dinucleotide reduced

metaM Ser Gly Ala X Gly l
type: Species
notes: FORMULA: XH CHARGE: 0
has only substance units: false
is: HMDB02183
is: SBO:0000247
boundary condition: false
constant: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0

metaR B3GNT39g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b07290c4_d09c_4e5b_9dab_fed8bed45339
name: GPAM
type: Species
initial concentration: NaN
has only substance units: false
is: Q8N1G6
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:57678

metaM phaccoa c
constant: false
type: Species
initial concentration: 1.0
is: HMDB06503
is: SBO:0000247
is: CHEBI:57390
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
boundary condition: false
initial amount: NaN
name: phenylacetyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110030#_a90cfca4_5568_49f1_a65b_6ab10b77f779
boundary condition: true
name: PDE4A
is: SBO:0000252
is: P27815
has only substance units: false
constant: false
is encoded by: hsa:5141
initial amount: NaN
initial concentration: NaN
type: Species

metaR TYRt
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000269
kinetic law: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e04b120b_5944_4176_9509_ecf229ceb655
is: Q96E98
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6005
has only substance units: false
initial concentration: NaN
type: Species
name: RHAG
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_88626e3c_cd5f_47c6_893d_7ea471d2144f
has only substance units: false
is encoded by: hsa:4728
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFS8
is: O00217
initial concentration: NaN

metaM glygn3 c
notes: FORMULA: C42H71O36X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02137
has only substance units: false
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00127
type: Species
constant: false
is: SBO:0000247
name: glycogen, structure 3 (glycogenin-7[1,4-Glc])

http://identifiers.org/biomodels.db/MODEL1310110030#_d52c9760_e8ce_4a83_9128_88be875ff1a8
type: Species
name: PPA2
is: F8WDN9
is encoded by: hsa:27068
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR MM8Cg
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR r1147
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

metaR TCYNTt
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000

metaM dttp c
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
initial amount: NaN
is: C00459
name: dTTP
boundary condition: false
type: Species
is: CHEBI:37568
initial concentration: 1.0
is: HMDB01342

http://identifiers.org/biomodels.db/MODEL1310110030#_8e5f13c4_5cdc_44be_83a8_02f3f7774569
initial amount: NaN
type: Species
name: TREH
is: O43280
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11181

metaM HC00460 c
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
initial concentration: 1.0
is: CHEBI:58044
has only substance units: false
is: SBO:0000247
type: Species
name: 2,5-dihydroxybenzoate
initial amount: NaN
constant: false

metaR UDPtl
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
fast: false
name: udp intracellular transport
reversible: true
product: MODEL1310110030#

metaM udpg c
is: HMDB00286
is: C00029
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
initial concentration: 1.0
name: UDPglucose
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58367

metaM cgly e
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
is: HMDB00078
has only substance units: false
is: SBO:0000247
is: CHEBI:4047
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_084855cb_bbe2_44b3_88ed_111afcbd76c5
initial amount: NaN
is: SBO:0000252
name: SLC7A6
is encoded by: hsa:9057
type: Species
is: Q92536
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_392bbf83_e964_410c_b8fa_9f9d6a4a93ee
initial amount: NaN
boundary condition: true
name: HSD3B2
is: P26439
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3284
is: SBO:0000252
type: Species
constant: false

metaR r0531
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
fast: false
reversible: true
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is described by: ECO:0000000

metaR 2HBt2
name: 2-hydroxybutyrate cotransport with proton
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
reversible: true
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaM HC02020 r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
is: SBO:0000247
boundary condition: false
name: Cholesterol-ester-palm
is: CHEBI:3663
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_9b4beb36_a324_4716_a38a_32def6877bc1
is encoded by: hsa:5281
is encoded by: hsa:84720
name: PIGF:PIGO
has part: Q6IB04
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110030#_b4968852_b4f0_4f56_99e4_8f529d219119
is encoded by: hsa:5091
boundary condition: true
name: PC
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r1148
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
type: Reaction
name: Active transport
product: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_689b8777_86f6_4b4a_9bc8_19667f8bd344
initial amount: NaN
constant: false
is encoded by: hsa:8879
name: SGPL1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: O95470

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ac373e35_be59_4ed1_a417_11ba2bfcc81e
is encoded by: hsa:AU149534
is: SBO:0000252
boundary condition: true
name: _AU149534_1_m
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR LYStm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
fast: false
product: MODEL1310110030#
modifier: MODEL1310110030#
name: Lysine mitochondrial transport via ornithine carrier

http://identifiers.org/biomodels.db/MODEL1310110030#_a29a4317_7b09_45ea_b504_025b404021f8
is: Q5JT09
is encoded by: hsa:83549
is: SBO:0000252
name: UCK1
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN

metaR FATP2t
reactant: MODEL1310110030#
reversible: true
name: fatty acid electroneutral transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false

metaR BAAT2x
reactant: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
kinetic law: MODEL1310110030#
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
reversible: false
product: MODEL1310110030#
fast: false
is: SBO:0000176

metaR 34DHXMANDACOX
product: MODEL1310110030#
is described by: ECO:0000269
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
reversible: false
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_f51d6c6f_bb58_4e90_aeb6_76a3ee4efa4b
type: Species
constant: false
is: SBO:0000252
is: Q96AS2
initial amount: NaN
is encoded by: hsa:427
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ASAH1

metaR RE2677G
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
fast: false
is: SBO:0000176
name: RE2677
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaM CE2432 m
is: C01936
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false

metaR ACNAMPH
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_dc34a22b_5de9_4d71_a600_faca5aa8d01c
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: B3GALT5
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10317

metaR r0963
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
type: Reaction
product: MODEL1310110030#
name: Facilitated diffusion
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_c6f9317d_3a4e_4c90_a273_fee7148f044c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:51
is: B4DK61
name: ACOX1
has only substance units: false
constant: false

metaR TXA2te
name: thromboxane A2 transport
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
reversible: true
is: SBO:0000185
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_71ecd22a_3630_4f55_8e95_7b3c72a3b840
has only substance units: false
boundary condition: true
name: _AI924226_1_m
is encoded by: hsa:AI924226
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM 4hglusa m
is: HMDB06556
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
type: Species
constant: false
boundary condition: false
is: CHEBI:27809

metaR NACHEX14ly
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
modifier: MODEL1310110030#

metaR PAPtg
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110030#
name: adenosine 3',5'-bisphosphate Golgi transport
product: MODEL1310110030#

metaR r0642
type: Reaction
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000
is: SBO:0000176

metaM gly m
is: C00037
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15428
initial concentration: 1.0
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
has only substance units: false
is: HMDB00123
name: Glycine

http://identifiers.org/biomodels.db/MODEL1310110030#_a66bbd49_e33c_4f5f_bfcc_06ede2f03226
initial amount: NaN
is: O15120
constant: false
is: SBO:0000252
initial concentration: NaN
name: AGPAT2
is encoded by: hsa:10555
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_88f391c3_c267_4b74_94bb_bf348d02db5e
is encoded by: hsa:3030
initial amount: NaN
has only substance units: false
is: E9KL44
boundary condition: true
type: Species
is: SBO:0000252
name: HADHA
constant: false
initial concentration: NaN

metaM g2m8mpdol L r
boundary condition: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
is: C05870
constant: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_a8579967_50ff_4974_8892_ac6a9be3717e
name: GUCY1A2
boundary condition: true
is: P33402
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2977
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e6722be8_23cd_45f3_8147_2cb73053ea28
is encoded by: hsa:767
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: CA8
is: P35219

metaM dump m
is: SBO:0000247
initial amount: NaN
is: HMDB01409
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
type: Species
has only substance units: false
name: dUMP(2-)
is: CHEBI:246422

http://identifiers.org/biomodels.db/MODEL1310110030#_c576793b_8a29_420d_a79f_9e153cb50363
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4695
is: O43678
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NDUFA2
constant: false

metaR OXAHCOtex
is described by: ECO:0000304
name: oxalate transport via bicarbonate countertransport
product: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b8430742_3cc3_4997_8c3a_fb9e05751135
is encoded by: hsa:114
boundary condition: true
type: Species
is: Q4F7X0
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: ADCY8

metaR r0641
modifier: MODEL1310110030#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
fast: false
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR 2OXOADOXm
reversible: false
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
product: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.61
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR PGS
is: SBO:0000176
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.99.1
type: Reaction
name: Prostaglandin G/H synthase
fast: false
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0d5c6e85_9565_42d5_861a_b81d3311d0b5
name: SLC3A2
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6520
initial amount: NaN
has only substance units: false
constant: false
is: P08195

metaM ksi deg8 l
is: SBO:0000247
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 8
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
has only substance units: false
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110030#_d65ad374_71e9_4707_baf5_3c636eb84dc0
is: F5GWS5
is encoded by: hsa:55811
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ADCY10
constant: false
type: Species
initial concentration: NaN

metaR r0960
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_3ec90805_3828_4ee7_982d_bd77c0fd0c0e
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q16348
is encoded by: hsa:6565
initial amount: NaN
boundary condition: true
name: SLC15A2

http://identifiers.org/biomodels.db/MODEL1310110030#_b83a4d09_0e33_4fd8_8701_f5d321d0c25d
has only substance units: false
name: _AI769281_1_e
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI769281
boundary condition: true

metaR TKT2
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
modifier: MODEL1310110030#

metaM maltpt e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01296
has only substance units: false
is: C02052
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
name: maltopentaose

http://identifiers.org/biomodels.db/MODEL1310110030#_3ece6a23_6807_4f97_9457_a9b10ab1db2d
boundary condition: true
is: Q14376
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2582
constant: false
type: Species
name: GALE
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_f00ed3cc_2d5e_4fcf_b660_bcecb9f4ee28
is encoded by: hsa:54407
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q96QD8
initial concentration: NaN
initial amount: NaN
name: SLC38A2
type: Species

metaM ksii core2 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00175
boundary condition: false
is: C00130
is: CHEBI:58053

metaR SADT
fast: false
is described by: ECO:0000269
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction
name: sulfate adenylyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaR N3Tg
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.122
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD

metaM gdpfuc c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: GDP-L-fucose(2-)
is: HMDB01095
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN
is: CHEBI:57984
has only substance units: false

metaR TKT1
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase

metaR AMETt2m
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is: SBO:0000185
reactant: MODEL1310110030#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial

metaM L2aadp m
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58672
type: Species
initial amount: NaN
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
name: L-2-aminoadipate(1-)
is: SBO:0000247
initial concentration: 1.0

metaM gtp m
is: C00044
name: GTP
has only substance units: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
is: HMDB01273
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_57d7c01d_94e5_4e1a_ac36_57675965fe26
is encoded by: hsa:8525
is: SBO:0000252
constant: false
initial amount: NaN
name: DGKZ
type: Species
is: B7Z6M3
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM ggn c
boundary condition: false
is: SBO:0000247
is: CHEBI:57606
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: primed glycogenin (glycogenin-8[1,4-Glc])
is: HMDB00267
constant: false
type: Species
notes: FORMULA: C48H81O41X CHARGE: 0 INCHI: InChI=1/C6H11O5/c7-1-4-6(10)5(9)3(8)2-11-4/h2-10H,1H2/t3-,4+,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC02131

metaM e4hglu m
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: HMDB02273
is: SBO:0000247
initial amount: NaN
is: CHEBI:6331
type: Species
name: erythro-4-hydroxy-L-glutamate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a37641e6_c01c_4358_b079_b87e57c354c1
type: Species
constant: false
initial concentration: NaN
is: E9PHN8
is: SBO:0000252
is encoded by: hsa:9843
name: HEPH
boundary condition: true
has only substance units: false
initial amount: NaN

metaR FACOAL181i
fast: false
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
modifier: MODEL1310110030#
name: C181 fatty acid activation

metaM CE2435 m
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
is: C01936
type: Species
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_3170c138_67fd_4350_9fb5_330fb3fa1ba0
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:347734
name: SLC35B2
constant: false
is: Q8TB61

http://identifiers.org/biomodels.db/MODEL1310110030#_d03afaa4_7505_401a_8041_be9becb9ae94
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: HADHA
initial concentration: NaN
is encoded by: hsa:3030
is: E9KL44
has only substance units: false

metaR NAGA2ly
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is described by: ECO:0000000
reversible: false
name: N-acetylgalactosaminidase, alpha-
fast: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.49
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d9292c8e_3542_416b_b5ca_71cc2acfc870
is: SBO:0000252
type: Species
is: P36269
has only substance units: false
name: GGT5
initial concentration: NaN
constant: false
is encoded by: hsa:2687
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_4c8dbca5_2caf_4d2e_a64b_989c2e3bdfe0
initial amount: NaN
has only substance units: false
name: PDE8A
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252
is: H0YMZ7
initial concentration: NaN
type: Species
constant: false

metaR SUCCt2m
type: Reaction
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
name: succinate transport, mitochondrial
fast: false
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR ACACT1x
reversible: false
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
modifier: MODEL1310110030#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110030#_98c86f0c_792f_42d6_88c8_3457c99c1f3f
initial concentration: NaN
is: Q8IXW6
name: DPYSL3
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:1809
constant: false

metaR FKYNH
name: N-Formyl-L-kynurenine amidohydrolase
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false

metaR r0426
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

metaM CE5121 m
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
name: trans-3-decenoyl-CoA
is: CHEBI:57449
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false

metaM ksi pre36 g
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 36
is: SBO:0000247

metaR D 3AIBt
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
name: D-3-amino-isobutyrate transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR r1918
fast: false
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR UMPK4
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
name: UMP kinase (GTP)
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_ecd4de27_6b91_4f92_b9a2_5c3be9621e55
constant: false
name: GPX5
boundary condition: true
is: O75715
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2880
is: SBO:0000252
type: Species
initial amount: NaN

metaR URIK1
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110030#
name: uridine kinase (ATP:Uridine)
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110030#

metaM glcur c
has only substance units: false
initial amount: NaN
boundary condition: false
name: D-glucuronate
constant: false
type: Species
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
initial concentration: 1.0
is: SBO:0000247

metaM dlnlcgcoa c
is: CHEBI:27979
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial concentration: 1.0
initial amount: NaN
constant: false
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false

metaR GLCNACASE4ly
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
reversible: false
modifier: MODEL1310110030#

metaR THYMt
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110030#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
name: thymine reversible transport via facilated diffusion
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

metaR UMPK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: UMP kinase (dATP)
fast: false

metaM hs deg12 l
name: heparan sulfate, degradation product 12
initial concentration: 1.0
has only substance units: false
is: HMDB06254
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110030#_c6678efb_7b88_49d1_b505_64a9104ed602
initial concentration: NaN
has only substance units: false
name: HMOX2
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: P30519
type: Species
is encoded by: hsa:3163

metaR UMPK3
product: MODEL1310110030#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110030#
name: UMP kinase (UTP)
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_58925a30_7500_4dea_82aa_db5f36fb9ecd
boundary condition: true
is encoded by: hsa:23556
initial amount: NaN
name: PIGN
is: SBO:0000252
initial concentration: NaN
is: O95427
type: Species
constant: false
has only substance units: false

metaR RE3004M
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3004

metaM acmana c
initial amount: NaN
is: CHEBI:17122
initial concentration: 1.0
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: HMDB01129
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR 5MTHFt2le
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
name: 5-methyltetrahydrofolate transport via anion exchange
reactant: MODEL1310110030#

metaM 10fthf c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial concentration: 1.0
is: HMDB00972
name: 10-Formyltetrahydrofolate
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: C00234

metaM dgmp c
is: C00362
is: CHEBI:57673
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01044
name: dGMP
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaM q10 m
name: ubiquinone-10
is: CHEBI:46245
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
initial amount: NaN
type: Species

metaR TSTSTERONEtr
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
fast: false
name: testosterone intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM ddcacoa x
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
initial amount: NaN
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
is: CHEBI:57375
initial concentration: 1.0
is: SBO:0000247
is: C01832
constant: false
type: Species

metaM fru e
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
is: CHEBI:15824
is: HMDB00660
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00095
boundary condition: false
has only substance units: false
name: D-Fructose

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaM HC01609 e
initial amount: NaN
is: SBO:0000247
name: UroporphyrinogenI
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: CHEBI:28766
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c863f34e_897f_4e4c_b52d_7c30cb91ed2e
has part: E9KL44
has only substance units: false
type: Species
name: HADHA:HADHB
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000297
constant: false
is encoded by: hsa:3030
initial amount: NaN
boundary condition: true
has part: P55084

http://identifiers.org/biomodels.db/MODEL1310110030#_2ce55e5b_a5ba_407a_a726_3edb5a04ccdb
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR GLCt2 2
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
name: D-glucose transport in via proton symport
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:

metaM Ser Thr g
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
is: HMDB00645
constant: false
boundary condition: false
is: CHEBI:58336
initial concentration: 1.0

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM glcur e
boundary condition: false
has only substance units: false
constant: false
name: D-glucuronate
is: HMDB00127
type: Species
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
initial concentration: 1.0

metaR RE0568C
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (9045.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
modifier: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: true
name: RE0568
kinetic law: MODEL1310110030#
is: SBO:0000176

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
name: cholesterol precursor intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_812b3bcd_e97a_4972_a4fd_c138c7bb271b
constant: false
type: Species
is: P51570
boundary condition: true
is encoded by: hsa:2584
name: GALK1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR UMPK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
name: UMP kinase (dGTP)
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_9f62f525_9f2d_4f99_ba52_eff2c899581c
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_fcdff230_4368_4f9e_b49c_a00b613f09f6
name: AK5
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26289

metaR NDPK1n
kinetic law: MODEL1310110030#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110030#
fast: false
reversible: true

metaR FUMTSULtm
fast: false
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Fumarate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
product: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_46251166_e397_4556_8e94_7859f7748e1f
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9NRZ5
name: AGPAT4
is: SBO:0000252
is encoded by: hsa:56895
initial amount: NaN
constant: false

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)
has only substance units: false
is: CHEBI:57673
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01044
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_917b82c4_da13_4efd_94c9_798b40105fc3
is: O43674
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: NDUFB5
is: SBO:0000252
constant: false
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110030#_d058ed47_4ee8_401f_8e12_e47c7c1cc190
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P54868
constant: false
has only substance units: false
is encoded by: hsa:3158
initial concentration: NaN
name: HMGCS2
type: Species

metaM trdox m
is: CHEBI:18191
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: Oxidized thioredoxin
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_992f3c74_6ab4_47e4_9b0b_cc60592c6c23
type: Species
initial amount: NaN
initial concentration: NaN
name: _H53099_1_m
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:H53099
constant: false

metaR A MANASEly
modifier: MODEL1310110030#
type: Reaction
name: alpha-mannosidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.24
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
is: SBO:0000176

metaR r0796
is: SBO:0000176
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaR UMPK6
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dCTP)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#

metaM 4mop m
initial amount: NaN
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
is: SBO:0000247
has only substance units: false
constant: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: HMDB00695
boundary condition: false

metaR r0630
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.1
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

metaR FAOXC17C15m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaM leuktrE4 e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
name: leukotriene E4(1-)
constant: false
type: Species
is: HMDB02200
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

http://identifiers.org/biomodels.db/MODEL1310110030#_67914566_7d8c_4b9b_9c9e_b720e983a848
name: _LOC727762_1_m
type: Species
is encoded by: hsa:LOC727762
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR r0797
product: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110030#
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_9496c4fb_ff1a_4b3d_9660_73c27c37a41e
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O14975
type: Species
initial concentration: NaN
is encoded by: hsa:11001
boundary condition: true
name: SLC27A2
constant: false

metaM 5adtststerone c
is: HMDB02961
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
boundary condition: false

metaR DMNONCRNt
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
type: Reaction
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000

metaR DGULND
reactant: MODEL1310110030#
type: Reaction
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
is: SBO:0000176
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR NTD5m
kinetic law: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dTMP), mitochondrial
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5

http://identifiers.org/biomodels.db/MODEL1310110030#_d2ac0571_8f71_4815_8ddb_674c235762dc
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4715
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9Y6M9
name: NDUFB9

http://identifiers.org/biomodels.db/MODEL1310110030#_4bfe9f36_a90f_4841_be8d_4c1f4ee23c36
is encoded by: hsa:375056
boundary condition: true
has only substance units: false
is: Q5JRA6
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: MIA3
initial amount: NaN

metaR 3SALAOX
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
name: cysteinesulfinic acid oxidase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_36d9fe5b_9562_4b49_bd72_9fc2cb29f7ec
boundary condition: true
name: FTMT
initial amount: NaN
is: Q8N4E7
initial concentration: NaN
type: Species
is encoded by: hsa:94033
constant: false
has only substance units: false
is: SBO:0000252

metaR AG13T12g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_de7dc488_994a_4f3d_999a_62d46a75d8e2
boundary condition: true
is encoded by: hsa:4129
is: P27338
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: MAOB
initial concentration: NaN
has only substance units: false

metaR LEUTAm
reactant: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
kinetic law: MODEL1310110030#
fast: false
type: Reaction
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5ec32b3a_9a55_4ee4_939d_289a2f018f5c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4539
is: Q7GXZ4
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: ND4L

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR r2006
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
reversible: false

metaR UMPK2
is: SBO:0000176
modifier: MODEL1310110030#
name: UMP kinase (CTP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110030#_71d135cb_faf3_4c5b_89ce_c9ed5cc6894e
constant: false
initial amount: NaN
name: PECR
is: Q9BY49
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55825
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f6c5cd3d_b995_4d2f_9074_cfb73dcbded1
initial concentration: NaN
name: B3GALT5
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10317
constant: false
is: SBO:0000252

metaM lthstrl r
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168
has only substance units: false
constant: false
is: HMDB01170
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false

metaM man l
has only substance units: false
initial amount: NaN
is: CHEBI:16024
is: SBO:0000247
constant: false
initial concentration: 1.0
name: D-mannose
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169

metaR ACNACNGALGBSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
product: MODEL1310110030#
name: acnacngalgbside hs intracellular transport
reactant: MODEL1310110030#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_1a802bea_001e_451c_aa72_cf4635e907d7
name: _AI539321_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI539321
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_b5d0fc28_e0f2_4639_8813_bf069f1e1407
initial concentration: NaN
type: Species
boundary condition: true
name: DGAT2
initial amount: NaN
has only substance units: false
is: Q96PD7
is encoded by: hsa:84649
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8411f54f_08d9_45c2_8213_3f07f4f3e03d
is: SBO:0000252
type: Species
name: ALDH7A1
is: E7EPT3
initial concentration: NaN
is encoded by: hsa:501
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR CLPNDCOAtx
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
type: Reaction

metaR OCD11COACPT1
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r1876
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaM HC01223 m
type: Species
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_b11a9635_35b2_438e_a0f8_fdf33d57a276
initial amount: NaN
is encoded by: hsa:2582
has only substance units: false
constant: false
name: GALE
is: Q38G75
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM hpdcacoa m
is: HMDB06497
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: heptadecanoyl coa
has only substance units: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

metaR NAGLCAly
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
reactant: MODEL1310110030#
fast: false
name: N-acetylglucosaminidase, lysosomal

MODEL1310110030
reaction: metaR SPHINGStl
reaction: metaR CYTK4n
species: metaM pi x
species: metaM ptrc c
reaction: metaR ALADGLNexR
reaction: metaR LEUKTRF4t
species: metaM eicostetcoa c
reaction: metaR r0245
species: metaM dgtp c
reaction: metaR FUCASE2ly
reaction: metaR r2373
species: metaM oxa c
species: metaM accoa n
species: metaM clpndcoa x
reaction: metaR SUCCtp
reaction: metaR FORt2m
reaction: metaR RE0935E
reaction: metaR AG13T8g
reaction: metaR URAt
reaction: metaR r0836
species: metaM hepcoa m
reaction: metaR GALT
reaction: metaR r2123
species: metaM pail hs n
reaction: metaR P45027A15m
reaction: metaR r2101
species: metaM gdp g
species: metaM 2dp6mep m
reaction: metaR O2Stm
species: metaM cs a deg4 l
length unit: length
species: metaM ksi deg41 l
reaction: metaR GLNSERNaEx
species: metaM octd11ecoa c
reaction: metaR r2082
species: metaM cmpacna n
reaction: metaR r1785
reaction: metaR EX HC02202 LPAREN e RPAREN
species: metaM mi14p c
reaction: metaR PDE1
reaction: metaR CYTK13
species: metaM hpyr c
species: metaM thcholstoic x
reaction: metaR r0340
reaction: metaR GLUDxm
species: metaM CE1940 e
reaction: metaR r1010
notes: Thiele2013 - Bone marrow hematopoietic cells The model of bone marrow hematopoietic cells metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is described in the article: A community-driven global reconstruction of human metabolism. Thiele I, et al . Nature Biotechnology Abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. This model is hosted on BioModels Database and identified by: MODEL1310110030 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
reaction: metaR IZPN
species: metaM h2o x
reaction: metaR EX bilglcur LPAREN e RPAREN
reaction: metaR r0839
species: metaM met L c
species: metaM oagt3 hs e
species: metaM retinal c
reaction: metaR EX rib D LPAREN e RPAREN
reaction: metaR r0817
reaction: metaR r1651
reaction: metaR EX bhb LPAREN e RPAREN
reaction: metaR GLCAASE1ly
species: metaM bilirub r
reaction: metaR r1627
reaction: metaR DNDPt21m
reaction: metaR MANt1r
reaction: metaR S6TASE15ly
species: metaM coa g
species: metaM m1mpdol L c
species: metaM arachdcrn m
species: metaM ksi pre35 g
reaction: metaR EX citr L LPAREN e RPAREN
species: metaM 4hbzcoa m
species: metaM q10 m
reaction: metaR r0179
species: metaM cspg e l
reaction: metaR r2387
species: metaM udp r
species: metaM gal e
species: metaM ala L m
reaction: metaR TKT2
species: metaM retn c

http://identifiers.org/biomodels.db/MODEL1310110030#_2dc1015b_1e9a_484f_bea0_d9f0fff1a4f9
name: ST3GAL3
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6487
initial amount: NaN
type: Species
is: SBO:0000252

metaR ADMDC
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
name: adenosylmethionine decarboxylase
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.50
reactant: MODEL1310110030#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR NDP7er
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000000
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_48e26f56_9803_4945_aab4_0ad2185a52a0
initial amount: NaN
name: _AI191472_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI191472
has only substance units: false
type: Species
constant: false
boundary condition: true

metaR NACHEX8ly
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a941e6f5_b83d_44fe_9680_69cd88f575db
initial concentration: NaN
is encoded by: hsa:2974
type: Species
constant: false
name: GUCY1B2
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_0421a61c_2fff_4549_90c9_33512d7e97ba
constant: false
is encoded by: hsa:219
name: ALDH1B1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110030#_b8cee282_24d0_4b4e_8154_9881815efcbf
name: NDUFA10
type: Species
is encoded by: hsa:4705
constant: false
is: O95299
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_ecf77987_d05f_4d18_a6a9_9825d7188368
has only substance units: false
is: SBO:0000252
name: GPX1
initial amount: NaN
type: Species
is encoded by: hsa:2876
constant: false
initial concentration: NaN
is: P07203
boundary condition: true

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r2357
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000

metaR r1586
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_fcc89966_0c6b_4754_a0e2_68618b359b3a
initial concentration: NaN
name: RPIA
is: P49247
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:22934
boundary condition: true

metaR r2117
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110030#

MODEL1310110030#
species: metaM tyr L c
species: metaM hom L e
species: metaM octa c
species: metaM xtsn c
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
species: metaM L2aadp m
name: HEXA:HEXB
species: metaM CE0713 m
species: metaM glu L m
species: metaM HC02187 e
multipler: 1.0
species: metaM dlnlcgcoa c
species: metaM Rtotalcoa c
species: metaM 9 cis retfa e
species: metaM acetone m
species: metaM gluside hs l
species: metaM Nacasp m
species: metaM ksii core4 g
species: metaM 3hmbcoa m
species: metaM dutp n
species: metaM m2mpdol L c
species: metaM sphmyln hs c
stoichiometry: 0.545544
species: metaM CE2432 m
species: metaM dmnoncrn c
species: metaM Lkynr c
species: metaM sph1p c
species: metaM dgmp m
species: metaM dad 2 e
species: metaM co e
species: metaM aacoa x
species: metaM ura c
species: metaM ksii core2 pre6 g
species: metaM sT antigen g
species: metaM ksii core2 pre2 g
species: metaM tsul c
species: metaM 3mob c
species: metaM retinal c
species: metaM 2dp6mep m
species: metaM dopa c
species: metaM dtdp n
species: metaM hmgcoa c
species: metaM orn e
species: metaM CE5786 e
species: metaM alpa hs c
species: metaM CE4794 m
species: metaM hpdcacrn m
species: metaM glyc R m
species: metaM g2m8mpdol L r
species: metaM 3odcoa m
species: metaM gal1p c
species: metaM CE1936 e
species: metaM chlstol r
species: metaM nmn c
species: metaM Nacasp c
species: metaM hs deg11 l
species: metaM g3pc c
species: metaM ca2 c
species: metaM crm hs c
species: metaM 3pg c
species: metaM thbpt c
species: metaM arg L m
species: metaM h2o n
species: metaM pmtcoa m
species: metaM dttp n
species: metaM dc2coa m
species: metaM bildglcur c
species: metaM ksii core4 deg2 l
species: metaM cysam c
species: metaM ppi c
species: metaM hs deg2 l
species: metaM HC02204 e
value: -1000.0
value: 1000.0
species: metaM HC00591 m
species: metaM 6thf e
species: metaM acald e
species: metaM trdrd c
species: metaM ksi deg36 l
species: metaM cit m

http://identifiers.org/biomodels.db/MODEL1310110030#_cb3b9f3c_47a7_4d5d_ac7a_ac102cedb721
type: Species
initial concentration: NaN
is: P24310
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: COX7A1
is encoded by: hsa:1346

metaR CHOLt4
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
name: choline, sodium cotransport

metaM CE2705 n
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: quinonoid dihydrobiopterin
is: CHEBI:15374
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: HMDB02281
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5e22a777_97b8_4e62_a630_4ef28aac093f
constant: false
is: SBO:0000252
is: Q13370
boundary condition: true
name: PDE3B
is encoded by: hsa:5140
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_0ea85239_07fb_4888_ab1d_601d5e9ba676
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5742
boundary condition: true
constant: false
name: PTGS1
has only substance units: false
is: P23219

http://identifiers.org/biomodels.db/MODEL1310110030#_0319f499_c870_4780_b7ad_8d8162afdc63
initial amount: NaN
type: Species
has only substance units: false
name: TYMP
is: P19971
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1890

http://identifiers.org/biomodels.db/MODEL1310110030#_134d42c6_eb68_4f06_89f8_1305b82aff51
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7167
is: Q53HE2
name: TPI1
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_aeee2fdc_6ec5_45d4_8611_19f75331a789
constant: false
name: _AA177072_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA177072
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2358
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: true
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110030#_78f64dd7_a999_485d_bf9a_8f06125888c5
type: Species
boundary condition: true
initial amount: NaN
name: COX6C
is: P09669
is encoded by: hsa:1345
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r1585
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#

metaR r2118
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_b9a557e1_c01f_4327_b84b_7ab85c039c5f
name: SLC9A3
boundary condition: true
is: P48764
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6550
has only substance units: false
type: Species

metaM Ser Thr l
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB06254
type: Species
initial concentration: 1.0
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
notes: FORMULA: XH CHARGE: 0
constant: false

metaR RE1254C
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: RE1254
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_2414225b_cf33_43e0_aa53_2b8765e8e41e
constant: false
is encoded by: hsa:23464
is: E2QC23
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: GCAT

metaM pi x
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00973
boundary condition: false
is: CHEBI:43474
type: Species
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
constant: false

metaM 3ohdcoa x
is: CHEBI:57349
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
is: HMDB06402
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
type: Species

metaR r1584
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM man g
type: Species
name: D-mannose
is: HMDB00169
is: CHEBI:16024
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false

metaR r2359
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
fast: false

metaR r2115
reversible: true
modifier: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6a867b01_b284_4c93_90d6_efdb9601d4a0
initial amount: NaN
has only substance units: false
constant: false
name: GALNT12
boundary condition: true
is encoded by: hsa:79695
is: Q8IXK2
is: SBO:0000252
initial concentration: NaN
type: Species

metaR GALASE20ly
is: SBO:0000176
reversible: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110030#
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110030#

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
type: Species
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
initial amount: NaN
is: CHEBI:28325
constant: false
has only substance units: false
is: SBO:0000247

metaM Rtotalcoa c
initial amount: NaN
type: Species
is: SBO:0000247
name: R total Coenzyme A
boundary condition: false
has only substance units: false
constant: false
is: HMDB01448
is: CHEBI:16189
initial concentration: 1.0
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

metaR r1583
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110030#

metaM 34dhmald c
type: Species
name: 3,4-Dihydroxymandelaldehyde
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903
constant: false
is: SBO:0000247
initial amount: NaN
is: C05577
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_bd94fcc4_37ce_4d24_a4f4_43f6bfbc9cb4
boundary condition: true
initial concentration: NaN
is encoded by: hsa:641372
is: Q3I5F7
constant: false
is: SBO:0000252
has only substance units: false
name: ACOT6
initial amount: NaN
type: Species

metaR PAIL45P HStn
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false

metaR H2O2tp
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110030#
reversible: true
type: Reaction
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5e7f89f4_b6b1_48af_bd2a_e905b9b80558
is: Q6P1M0
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10999
initial amount: NaN
name: SLC27A4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5367c163_5be5_4980_8dec_8134d01edddd
is encoded by: hsa:211
name: ALAS1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q5JAM2
constant: false
type: Species
boundary condition: true

metaR CATm
is version of: http://identifiers.org/ec-code/1.11.1.6
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
modifier: MODEL1310110030#
name: catalase
reversible: false
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction

metaR r2116
fast: false
modifier: MODEL1310110030#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_dba70ec5_3630_496b_b3df_4f1f6c6d0856
is: P20674
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: COX5A
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9377

metaR 4HBZFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
name: 4-hydroxybenzoate formation
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaM decdp m
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: all trans Decaprenyl diphosphate
type: Species
is: HMDB06288
initial amount: NaN

metaR F6Tg
reversible: false
is described by: ECO:0000000
name: glycoprotein 6-alpha-L-fucosyltransferase
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
product: MODEL1310110030#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR S6TASE12ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR UMPK
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: UMP kinase

http://identifiers.org/biomodels.db/MODEL1310110030#_b78f4ea4_7f0e_47f0_9c7e_7e17a9ac1105
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: PDE7A
is encoded by: hsa:5150

http://identifiers.org/biomodels.db/MODEL1310110030#_0e68345c_90f8_455c_bda7_9b2088197934
is encoded by: hsa:9107
type: Species
boundary condition: true
has only substance units: false
constant: false
name: MTMR6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9Y217

metaR DHCR72r
is described by: ECO:0000269
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
product: MODEL1310110030#
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110030#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_6ec6de01_7d53_4eae_b048_d9302fb2c556
type: Species
is: Q5SYN6
is encoded by: hsa:6581
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC22A3

metaR PROt4
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
product: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: false
name: Na+/Proline-L symporter
reactant: MODEL1310110030#
is: SBO:0000185

metaM man e
is: HMDB00169
constant: false
is: CHEBI:16024
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
name: D-Mannose

metaR PAFt
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
is: SBO:0000185
product: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_1c847251_33d2_4e36_ab80_d5bff63f99b3
is: P20020
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:490
constant: false
is: SBO:0000252
name: ATP2B1

metaM fald l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
is: CHEBI:16842
name: formaldehyde
is: HMDB01426
type: Species
constant: false

metaM dolmanp L c
boundary condition: false
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247

metaR r1589
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_5757bef0_8bff_43c7_8506_79ee3a5defdd
is: O00400
is encoded by: hsa:9197
type: Species
constant: false
name: SLC33A1
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r2119
modifier: MODEL1310110030#
is: SBO:0000185
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR MECOAS1m
reversible: true
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF

http://identifiers.org/biomodels.db/MODEL1310110030#_3049a9b6_ba69_4e95_83a3_6bfc9c846d24
is: B3KXN9
initial concentration: NaN
type: Species
has only substance units: false
name: ADO
initial amount: NaN
is encoded by: hsa:84890
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_fb104124_fc03_49ee_afc6_cf86fa058066
is encoded by: hsa:5149
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q13956
name: PDE6H
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_34917d57_2ec4_4d60_be69_b67894f86cf1
name: CLC
is encoded by: hsa:1178
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: C5HZ13
has only substance units: false
constant: false
initial amount: NaN

metaM man c
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00169
name: D-Mannose
initial concentration: 1.0
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: CHEBI:16024
type: Species
is: SBO:0000247

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
reversible: true

metaR r1588
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
fast: false
product: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaR AK2LGCHOLt
reversible: true
is: SBO:0000185
product: MODEL1310110030#
fast: false
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_b3cd56c3_e080_4deb_b677_2d1d9791dccc
has only substance units: false
is encoded by: hsa:123041
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC24A4
is: SBO:0000252

metaM grdp x
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
initial amount: NaN
is: HMDB01285
has only substance units: false
is: CHEBI:58057
boundary condition: false
name: geranyl diphosphate(3-)
initial concentration: 1.0

metaM 20ahchsterol m
name: 20-hydroxycholesterol
is: HMDB06283
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:1296
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500

http://identifiers.org/biomodels.db/MODEL1310110030#_eaeb6ee5_4a2c_446a_8501_e5c6855aa3bb
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: ABAT
is encoded by: hsa:18
initial amount: NaN

metaM ksi pre33 g
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00130
is: CHEBI:58053
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: HMDB00175
initial concentration: 1.0
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 33
initial amount: NaN

metaR r1587
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110030#

metaR EBP1r
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/5.3.3.5
type: Reaction
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_884a4e87_1e58_49a1_afcf_9f3a1864da06
is encoded by: hsa:3633
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: P32019
name: INPP5B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7447548a_1f81_48bd_820e_460ea2bf4efe
name: ACSL5
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q9ULC5
is encoded by: hsa:51703

metaM glyc3p c
is: HMDB00126
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
name: Glycerol 3-phosphate
is: CHEBI:57597
type: Species
constant: false
initial amount: NaN

metaM val L m
is: HMDB00883
initial concentration: 1.0
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: L-valine
is: CHEBI:16414
initial amount: NaN

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM 3mob c
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
is: SBO:0000247
is: HMDB00019
initial concentration: 1.0
initial amount: NaN

metaM xoltri24 r
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)23(29)9-6-17(3)20-7-8-21-25-22(11-13-27(20,21)5)26(4)12-10-19(28)14-18(26)15-24(25)30/h15-17,19-25,28-30H,6-14H2,1-5H3/t17-,19+,20-,21+,22+,23+,24-,25+,26+,27-/m1/s1
has only substance units: false
is: CHEBI:37640
initial concentration: 1.0
initial amount: NaN
name: (24S)-7alpha,24-dihydroxycholesterol
constant: false

metaR CYTK12
reversible: true
is described by: ECO:0000269
product: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110030#
name: cytidylate kinase (dCMP,dCTP)
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
kinetic law: MODEL1310110030#

metaR r2122
reversible: true
reactant: MODEL1310110030#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110030#_68a38c7e_a040_42fa_9885_5080873eb993
type: Species
boundary condition: true
is encoded by: hsa:AI285872
constant: false
has only substance units: false
name: _AI285872_1_c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_6a7f77d8_e09b_4629_8aed_a159e42c07fa
has only substance units: false
constant: false
is encoded by: hsa:4714
is: SBO:0000252
is: O95169
initial amount: NaN
name: NDUFB8
initial concentration: NaN
boundary condition: true
type: Species

metaR r2362
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR LTC4CP
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Leukotriene C4 carboxypeptidase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ

metaR ETOHt
reversible: true
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
name: ethanol reversible transport
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185

metaM aacoa c
initial concentration: 1.0
is: HMDB01484
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00332
name: Acetoacetyl-CoA
initial amount: NaN
type: Species
constant: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM urcan c
name: Urocanate
is: HMDB00301
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00785
is: CHEBI:17771
initial amount: NaN

metaM oxa e
is: CHEBI:30623
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: oxalate(2-)
is: HMDB02329
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_80077174_fc2d_41ec_9cac_139a8bfc2c63
initial concentration: NaN
is: A6NN98
is encoded by: hsa:8898
type: Species
initial amount: NaN
constant: false
name: MTMR2
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR CYTK13
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
reversible: true
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR BUTt2r
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
name: Butyrate transport via proton symport, reversible

metaM chol n
is: HMDB00097
boundary condition: false
name: choline
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
type: Species
is: CHEBI:15354

http://identifiers.org/biomodels.db/MODEL1310110030#_952653a2_a7c7_474e_8d10_f58223a412d1
name: GYG1:GYS1
has only substance units: false
has part: P13807
boundary condition: true
is encoded by: hsa:2997
initial amount: NaN
constant: false
type: Species
is: SBO:0000297
initial concentration: NaN

metaR G14T12g
fast: false
type: Reaction
modifier: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110030#_f0adb730_c3d1_489a_ad0c_a8784aabbba9
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6NSB3
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:276
name: AMY1A

metaR r2121
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is: SBO:0000185

metaR r1590
product: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2361
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110030#
type: Reaction

metaM rbt c
boundary condition: false
is: CHEBI:15963
is: HMDB00508
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
type: Species
constant: false

metaM 3mob e
has only substance units: false
is: HMDB00019
type: Species
initial amount: NaN
name: 3-methyl-2-oxobutanoate
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
is: CHEBI:11851

metaR r2120
reversible: true
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR CYTK14
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
product: MODEL1310110030#
name: cytidylate kinase (dCMP,UTP)

metaR r2364
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaM glyc3p x
is: CHEBI:57597
is: HMDB00126
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial concentration: 1.0
is: C00093
has only substance units: false
initial amount: NaN
name: Glycerol 3-phosphate
boundary condition: false
is: SBO:0000247

metaM decdp c
initial amount: NaN
name: all trans Decaprenyl diphosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
is: HMDB06288
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR r0488
kinetic law: MODEL1310110030#
type: Reaction
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaM oxa c
is: CHEBI:30623
has only substance units: false
name: oxalate(2-)
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
type: Species
initial amount: NaN

metaR MI1PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
name: myo-inositol 1-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110030#_5cc1c264_a277_4a92_9d9f_5234721f73eb
type: Species
is: Q546Y9
has only substance units: false
constant: false
is: SBO:0000252
name: AICDA
is encoded by: hsa:57379
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_ddd91895_2cc4_4a18_97a4_4b63b09d6631
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2977
name: GUCY1A2:GUCY1B3
type: Species
initial amount: NaN
constant: false
is: SBO:0000297
has part: Q02153
is encoded by: hsa:2983
has part: P33402

metaM cs a l
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02183
is: CHEBI:36005
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1a9757c7_f01a_4f44_9b1a_981d3017fb32
constant: false
is: P14618
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5315
name: PKM2

metaR r2363
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_394f5946_5f49_45de_877f_7543f9b90480
is encoded by: hsa:2806
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: GOT2
type: Species
is: P00505
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_329ef9b3_b319_440d_9d34_403331717ed7
is encoded by: hsa:57786
name: RBAK
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9NYW8
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR ACHEe
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.7
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
kinetic law: MODEL1310110030#
fast: false
name: Acetylcholinesterase
is described by: ECO:0000269
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
reactant: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
name: b-ureidopropionase
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_e40162ed_a266_4da0_92d9_05db512645eb
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q9UI40
is encoded by: hsa:25769
initial amount: NaN
name: SLC24A2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d8ff6442_3776_4786_a10e_064b66210ee8
is encoded by: hsa:9517
boundary condition: true
constant: false
is: O15270
name: SPTLC2
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR r2126
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9d4ef3f5_326c_4052_bff5_bfd48517a555
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:159
name: ADSS
boundary condition: true
has only substance units: false
is: P30520
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e7554c60_bab9_4278_8e7d_a378b6b83218
is: P13807
name: GYS1
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2997
type: Species
has only substance units: false

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: ITP(3-)
initial concentration: 1.0
is: CHEBI:57614
constant: false
is: HMDB00189

metaR MI1PS
product: MODEL1310110030#
is described by: ECO:0000269
name: myo-Inositol-1-phosphate synthase
reversible: false
is version of: http://identifiers.org/ec-code/5.5.1.4
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_44ee610c_0ca4_48cc_8664_9f909588dae3
has only substance units: false
initial amount: NaN
constant: false
is: Q16853
initial concentration: NaN
is encoded by: hsa:8639
type: Species
name: AOC3
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a6ba6d9c_d632_40cf_bb5d_4b404a436c39
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:8879
boundary condition: true
initial amount: NaN
has only substance units: false
name: SGPL1
is: O95470

http://identifiers.org/biomodels.db/MODEL1310110030#_aab33506_d7e2_4c83_94da_58719c810b2b
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
is: P42765
initial concentration: NaN

metaR r1593
reversible: true
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110030#_731540e8_dd37_4a9d_9619_ad0e401ed944
is: Q99755
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8394
constant: false
boundary condition: true
type: Species
name: PIP5K1A

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR DPPS
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: decaprenyl synthase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000134
type: Reaction

metaR r2125
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110030#

metaM tag hs e
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17855
name: triglyceride
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8e4249f9_151a_4d22_a927_8ab27d7092c0
initial concentration: NaN
name: NT5E
is: P21589
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4907

metaR ALAGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)

metaR CATp
is described by: ECO:0000134
product: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.11.1.6
name: catalase A, peroxisomal
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.6 Confidence Level: 0 AUTHORS: PMID:18634816,PMID:18634817 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110030#
type: Reaction

metaR r2365
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110030#

metaR GALNTg
name: GalNAc transferase, Golgi apparatus
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaR ACNAM9PL
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is version of: http://identifiers.org/ec-code/2.5.1.56
reversible: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_83a1d139_3c2e_4cd2_914f_581e75477ff8
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: DPM2
type: Species
is encoded by: hsa:8818
initial concentration: NaN

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185

metaM C04849 e
initial concentration: 1.0
is: CHEBI:57449
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849

metaM cys L e
type: Species
name: L-cysteine
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
is: SBO:0000247
is: HMDB00574
boundary condition: false
has only substance units: false
is: CHEBI:17561
initial concentration: 1.0
initial amount: NaN

metaR CITL
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
name: Citrate lyase
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#

metaM ddcacoa m
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
is: C01832
constant: false
is: HMDB03571
type: Species
is: CHEBI:57375
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)

metaR r2124
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4c2ddeb1_4a8c_48e3_8f52_6c89515649ef
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: GYG2
is encoded by: hsa:8908
is: O15488

metaR r1434
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
name: Transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaR r2368
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR r1591
reversible: true
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM 10fthf m
has only substance units: false
initial concentration: 1.0
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: SBO:0000247
is: CHEBI:57454
boundary condition: false

metaR GLXO2p
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.3.15
name: glyoxylate oxidase, peroxisomal
kinetic law: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_448abcab_0416_44a7_b217_0c0669ad2e9b
initial concentration: NaN
name: UGP2
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:7360
has only substance units: false
initial amount: NaN

metaR S23Tg
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
modifier: MODEL1310110030#

metaM 5adtststerone r
boundary condition: false
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: CHEBI:16330
initial amount: NaN

metaR r2123
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#

metaR KSII CORE4tly
product: MODEL1310110030#
is: SBO:0000185
name: keratan sulfate II (core 4) transport, extracellular to lysosome
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110030#
type: Reaction
fast: false

metaR DOLPMT2 Ler
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000

metaR r0339
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaR r2367
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110030#
reversible: true
is: SBO:0000185

metaR r1435
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM q10h2 e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB13111
has only substance units: false
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_17837d67_5af6_4559_9bd3_fbffeae62065
type: Species
is: O14772
is encoded by: hsa:8790
name: FPGT
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r1592
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM cys L c
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
name: L-cysteine
initial amount: NaN
type: Species
is: HMDB00574
constant: false
boundary condition: false
is: CHEBI:17561
initial concentration: 1.0
has only substance units: false

metaR ACACT7p
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
is described by: ECO:0000269

metaR LGTHL
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.4.1.5
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
type: Reaction
name: lactoylglutathione lyase
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF

metaR HISSNAT5tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM HC01401 m
is: CHEBI:27668
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA

metaM ksi deg32 l
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 32
is: CHEBI:12936
is: HMDB00143
constant: false
initial amount: NaN
notes: FORMULA: C82H135N5O67S2 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110030#_06f6ef6e_8225_4871_884b_4214e1f021c3
boundary condition: true
constant: false
has only substance units: false
name: DPM3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54344
is: Q86TM7
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_5208e676_7270_42f7_bfea_ecc12e97dc75
constant: false
has only substance units: false
is encoded by: hsa:4725
type: Species
is: Q6IBA0
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFS5
initial concentration: NaN

metaR S6TASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: true
is: SBO:0000176
type: Reaction

metaM q10 e
is: CHEBI:46245
is: HMDB01072
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: ubiquinone-10
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaM q10h2 c
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
name: Ubiquinol-10
type: Species
is: HMDB13111
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR ADSL1
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
is described by: ECO:0000269
name: adenylosuccinate lyase

metaM anth c
boundary condition: false
has only substance units: false
is: HMDB01123
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16567
name: anthranilate
initial concentration: 1.0

metaM btcoa m
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57371
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: C00136
boundary condition: false
is: HMDB01088
has only substance units: false
type: Species

metaR r1433
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110030#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r0634
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
modifier: MODEL1310110030#
type: Reaction
fast: false
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR UMPK7n
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR 5MTHFt
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
product: MODEL1310110030#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
modifier: MODEL1310110030#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_d7f3a5f2_86ea_4966_aea4_d7892cb2bace
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AL050025
name: _AL050025_1_c
initial amount: NaN
type: Species
boundary condition: true

metaR DHAAt1r
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269
name: dehydroascorbate transport (uniport)
reversible: true
type: Reaction
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_104a6ae3_0355_45e6_8744_b1a8a0ec82bc
name: MUT
type: Species
is: P22033
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4594
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_f349bfde_ba76_4dc4_a140_462095be8a0a
constant: false
is: P04040
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:847
has only substance units: false
is: SBO:0000252
name: CAT

metaR q10tm
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110030#
reversible: true
fast: false
type: Reaction

metaR CSEPASEly
type: Reaction
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000176
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110030#
reversible: false

metaR ADSL2
type: Reaction
reversible: false
reactant: MODEL1310110030#
fast: false
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
product: MODEL1310110030#
is described by: ECO:0000269
kinetic law: MODEL1310110030#

metaM cs b l
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: CHEBI:36005
has only substance units: false
is: HMDB02183
constant: false
boundary condition: false

metaR AG13T11g
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110030#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#

metaM dgmp m
is: HMDB01044
name: dGMP
is: C00362
is: CHEBI:57673
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
boundary condition: false
has only substance units: false

metaM itp e
name: ITP(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57614
boundary condition: false
is: HMDB00189
initial amount: NaN
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
product: MODEL1310110030#

metaM chol e
type: Species
constant: false
is: HMDB00097
name: Choline
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: CHEBI:15354
initial concentration: 1.0

metaR DNDPt35m
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110030#
reversible: false
is: SBO:0000185

metaM 5adtststerone e
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: CHEBI:16330
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
is: HMDB02961
boundary condition: false
is: SBO:0000247

metaR THP2Ctp
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal

metaM anth e
is: CHEBI:16567
initial amount: NaN
is: HMDB01123
is: SBO:0000247
boundary condition: false
constant: false
name: anthranilate
initial concentration: 1.0
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
has only substance units: false

metaR GLNASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
kinetic law: MODEL1310110030#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110030#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM dolmanp L r
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
has only substance units: false

metaR r1431
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1

metaR ACITL
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.3.8
is: SBO:0000176
name: ATP-Citrate lyase
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction

metaM retinol 9 cis e
is: HMDB06217
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
name: 9-cis-retinol
constant: false
is: CHEBI:17336
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_7509e5fa_2f68_49d9_9bb2_25f0a2cd47c4
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:80025
has only substance units: false
initial amount: NaN
name: PANK2

metaR THYOXt2
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: T4 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: true

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR C226CPT1
name: carnitine C22:6 transferase
kinetic law: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_93714045_927f_44c3_a88a_e7dad19d5f49
is encoded by: hsa:AA788780
name: _AA788780_1_c
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR ALAR
reversible: true
type: Reaction
name: alanine racemase
reactant: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110030#
is described by: ECO:0000212
is: SBO:0000176

metaR NDPK2n
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR r2013
kinetic law: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM ksi pre1 g
initial amount: NaN
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 1
is: C00130
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: HMDB00175
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_e7669028_5fa8_47f7_95df_857340ee1f40
is encoded by: hsa:2766
has only substance units: false
initial concentration: NaN
type: Species
is: P36959
name: GMPR
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_e298c4b4_65f6_42be_9fd0_63e6e3005b6b
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:205
boundary condition: true
name: AK4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d32e7b28_433d_477a_af24_2b785c36a6a3
boundary condition: true
is encoded by: hsa:8813
has part: O94777
is encoded by: hsa:8818
type: Species
initial amount: NaN
has part: O60762
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q86TM7
name: DPM3:DPM1:DPM2
constant: false
is encoded by: hsa:54344

http://identifiers.org/biomodels.db/MODEL1310110030#_77800310_549f_4ab1_a621_451e29ba6ea5
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3038
is: O00219
boundary condition: true
is: SBO:0000252
name: HAS3

http://identifiers.org/biomodels.db/MODEL1310110030#_1d68ed8c_f278_48d9_9c0a_2c81dbf3b690
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PPAP2C
constant: false
initial amount: NaN
is encoded by: hsa:8612
is: E9PAY8
type: Species
initial concentration: NaN

metaR HIBDm
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM rbt e
type: Species
constant: false
is: SBO:0000247
is: HMDB00508
is: CHEBI:15963
initial concentration: 1.0
has only substance units: false
name: D-ribitol
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN

metaR 5OXPROt
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110030#
reversible: true
name: Transport of 5-oxoprolinate
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_cfbf7811_ce31_4f65_8306_7185f3066fdc
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _R39999_1_c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:R39999

http://identifiers.org/biomodels.db/MODEL1310110030#_cade171a_b86b_430b_beee_69b6f9b94b7f
boundary condition: true
name: RDH14
is encoded by: hsa:57665
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9HBH5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_b5b3fced_80d7_4ea7_8b26_eff307488922
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI694761_1_c
is encoded by: hsa:AI694761
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaM cs e deg3 l
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
boundary condition: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
has only substance units: false
is: SBO:0000247
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_6cb08a46_f05d_4b9d_bf14_2aa4b7082689
name: ACAA1
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q96CA6
boundary condition: true
is encoded by: hsa:30

metaM spmd c
constant: false
is: HMDB01257
type: Species
boundary condition: false
is: CHEBI:57834
initial amount: NaN
name: Spermidine
has only substance units: false
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
initial concentration: 1.0

metaM 2dr1p c
is: C00672
is: HMDB01351
is: CHEBI:58576
type: Species
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0638
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.2
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR DHORTS
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
name: dihydroorotase
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
type: Reaction

metaR r2360
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM 3ohdcoa m
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
constant: false
is: CHEBI:57349
initial amount: NaN
is: HMDB06402
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_88a681c3_61c9_484e_91cf_3c4a7419f9a4
boundary condition: true
initial amount: NaN
is encoded by: hsa:3423
name: IDS
type: Species
constant: false
initial concentration: NaN
is: B4DGD7
is: SBO:0000252
has only substance units: false

metaM q10 c
initial concentration: 1.0
is: CHEBI:46245
is: SBO:0000247
name: ubiquinone-10
is: HMDB01072
type: Species
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_32855702_91fb_40ae_a7c6_5960ed3804c9
name: LDHAL6B
initial concentration: NaN
is encoded by: hsa:92483
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is: Q9BYZ2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_9018231e_2ed6_4493_9cb2_4c8e2b7c1a41
is encoded by: hsa:7389
initial amount: NaN
is: P06132
initial concentration: NaN
type: Species
name: UROD
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR IDOURte
reactant: MODEL1310110030#
name: L-iduronate transport, extracellular
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reversible: true

metaR LYSOXp
reversible: false
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_7bd4aa2f_cbf0_4511_8a63_bb70bfafa485
is: F8WAB8
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC25A26
is encoded by: hsa:115286
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR C226CPT2
is: SBO:0000176
kinetic law: MODEL1310110030#
name: C226 transport into the mitochondria
reactant: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5b5d261f_da18_4ec2_8dfa_7349a3974305
type: Species
is: SBO:0000252
is: P00338
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3939
name: LDHA
constant: false

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM spmd e
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57834
boundary condition: false
is: C00315
name: Spermidine
is: SBO:0000247
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: HMDB01257
has only substance units: false

metaR r0331
type: Reaction
is: SBO:0000176
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
kinetic law: MODEL1310110030#
fast: false

metaM glyclt c
initial concentration: 1.0
type: Species
name: glycolate
is: HMDB00115
constant: false
initial amount: NaN
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
is: SBO:0000247
is: CHEBI:29805
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f93c7347_7c22_45f9_8deb_ad62f4b3f9f7
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P11168
type: Species
name: SLC2A2
is encoded by: hsa:6514
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_724c415c_349a_4fef_8194_27138c3dda56
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3614
constant: false
name: IMPDH1
has only substance units: false
is: SBO:0000252
is: C9JV30

http://identifiers.org/biomodels.db/MODEL1310110030#_8b39b025_c284_444c_8630_9c9a8354192b
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AW277253_1_c
is encoded by: hsa:AW277253
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_586c2940_a189_45d1_bdeb_04e3eb38c348
is encoded by: hsa:217
initial concentration: NaN
name: ALDH2
has only substance units: false
type: Species
is: P05091
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: keratan sulfate II (core 2-linked)
is: HMDB01014
initial amount: NaN
is: CHEBI:57255
initial concentration: 1.0

metaM 3dpdhb me m
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
is: CHEBI:50776
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
type: Species
initial amount: NaN

metaM xoltri24 e
name: (24S)-7alpha,24-dihydroxycholesterol
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:37640
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)23(29)9-6-17(3)20-7-8-21-25-22(11-13-27(20,21)5)26(4)12-10-19(28)14-18(26)15-24(25)30/h15-17,19-25,28-30H,6-14H2,1-5H3/t17-,19+,20-,21+,22+,23+,24-,25+,26+,27-/m1/s1
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaM hs l
initial concentration: 1.0
name: heparan sulfate, free chain
boundary condition: false
initial amount: NaN
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
type: Species
is: SBO:0000247
is: CHEBI:28815
has only substance units: false
constant: false

metaR O2t
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
name: o2 transport (diffusion)
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_5dc40ca8_6e50_4570_9185_c956b611ee16
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2752
is: SBO:0000252
constant: false
is: P15104
name: GLUL
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_dc76cc80_8732_4ecd_bc42_1714f0b92712
is encoded by: hsa:3162
is: SBO:0000252
name: HMOX1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q6FH11
type: Species
constant: false
has only substance units: false

metaR PAFH
name: Platelet-activating factor acetylhydrolase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.47
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ

metaM hspg l
initial concentration: 1.0
is: SBO:0000247
is: HMDB01993
constant: false
is: CHEBI:17899
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
name: heparan sulfate proteoglycan
has only substance units: false

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial amount: NaN
name: proton
type: Species
constant: false
has only substance units: false
is: CHEBI:24636
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_de652ac0_6b69_4dd0_a055_f7761ea207fb
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5167
is: P22413
boundary condition: true
name: ENPP1
type: Species

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110030#

metaR MMMm
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/5.4.99.2
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110030#
name: methylmalonyl-CoA mutase
fast: false

metaR UAGALDP
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false

metaR SERTHRNaEx
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR ACALDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000
name: acetaldehyde reversible transport
reversible: true
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_894b871e_0831_4100_8c07_ff9b6c25f3a7
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: SLC7A8
is: Q9UHI5
is encoded by: hsa:23428
type: Species
has only substance units: false
is: SBO:0000252

metaR MAN1PT2
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.13
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
name: mannose-1-phosphate guanylyltransferase (GDP)

metaM sucsal m
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
name: Succinic semialdehyde
is: CHEBI:57706
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01259

metaR RE2799C
name: RE2799
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:

metaM xoltri24 c
boundary condition: false
constant: false
is: CHEBI:37640
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)23(29)9-6-17(3)20-7-8-21-25-22(11-13-27(20,21)5)26(4)12-10-19(28)14-18(26)15-24(25)30/h15-17,19-25,28-30H,6-14H2,1-5H3/t17-,19+,20-,21+,22+,23+,24-,25+,26+,27-/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: (24S)-7alpha,24-dihydroxycholesterol
has only substance units: false

metaR DPMVDx
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.33
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction

metaM dpcoa m
has only substance units: false
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: 3'-dephospho-CoA(2-)
is: HMDB01373
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM ksi pre22 g
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
is: C00130
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22

metaM ametam c
is: SBO:0000247
type: Species
is: HMDB00988
initial concentration: 1.0
name: S-Adenosylmethioninamine
is: C01137
constant: false
is: CHEBI:57443
has only substance units: false
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
initial amount: NaN
boundary condition: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM andrstrn r
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00031
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
name: androsterone
is: SBO:0000247
constant: false
is: CHEBI:16032

http://identifiers.org/biomodels.db/MODEL1310110030#_9597660c_1057_40d7_be52_1af0cda6693d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AA526438
name: _AA526438_1_m
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f5c60c68_747c_4ba7_b791_42a758da038b
initial concentration: NaN
constant: false
is encoded by: hsa:64499
boundary condition: true
initial amount: NaN
is: P20231
is: SBO:0000252
name: TPSB2
has only substance units: false
type: Species

metaM cspg e e
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16040
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
boundary condition: false
is: HMDB00630
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false

metaR r2018
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
fast: false

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7d396eb7_2732_4a01_9dd2_04bce3bd63cc
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:160851
initial amount: NaN
has only substance units: false
is: Q86XP1
boundary condition: true
name: DGKH

http://identifiers.org/biomodels.db/MODEL1310110030#_62a398bb_644d_4b30_a246_da3d97d91453
name: NDUFB9
is: Q9Y6M9
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4715
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_b5adaecd_4b0b_4247_842e_66d177859c3a
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: PDE9A
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5152

metaM h2o2 m
has only substance units: false
is: CHEBI:16240
is: HMDB03125
name: Hydrogen peroxide
is: SBO:0000247
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

metaR RE3003M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: RE3003
reactant: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8

metaM octd11ecoa m
boundary condition: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: HMDB13109
initial concentration: 1.0
name: 11-octadecenoylcoa
type: Species
is: SBO:0000247

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
has only substance units: false
is: CHEBI:17968
constant: false
type: Species
is: SBO:0000247
name: butyrate
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR r2019
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110030#
fast: false
type: Reaction
reactant: MODEL1310110030#
name: SPMTDe
kinetic law: MODEL1310110030#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_14e87d4c_2381_4423_9fbd_eb3b69a934c5
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLC2A4
is: P14672
is encoded by: hsa:6517

http://identifiers.org/biomodels.db/MODEL1310110030#_364a358b_c718_4530_b9b5_73db98122ab5
name: AK4
type: Species
is encoded by: hsa:205
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR AG13T13g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is: SBO:0000176
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_c0b2b3bc_945e_4386_bd25_1b953de54c27
is encoded by: hsa:293
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: SLC25A6
is: Q6I9V5
type: Species
is: SBO:0000252
initial concentration: NaN

metaM h2o2 l
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0
is: HMDB03125
boundary condition: false
name: hydrogen peroxide
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
type: Species
constant: false

metaR THFtm
product: MODEL1310110030#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e3ca08ac_4baf_4131_8600_d052d9872d80
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_m
type: Species

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_be4be565_dc7f_434b_ba5a_7f7f0fc61122
initial amount: NaN
type: Species
has only substance units: false
name: NAGA
is: P17050
is: SBO:0000252
constant: false
is encoded by: hsa:4668
initial concentration: NaN
boundary condition: true

metaM retinol 9 cis c
constant: false
is: SBO:0000247
is: CHEBI:17336
has only substance units: false
name: 9-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial concentration: 1.0
is: HMDB06217
type: Species
boundary condition: false
initial amount: NaN

metaR CSND
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
product: MODEL1310110030#
name: Cytosine deaminase

metaM ksii core2 e
is: HMDB00211
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
constant: false
boundary condition: false
is: CHEBI:17268
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 2-linked)

http://identifiers.org/biomodels.db/MODEL1310110030#_397c9260_f4ae_44dc_aa52_f4e3e9e44974
type: Species
initial concentration: NaN
is: Q9NY65
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:1962
name: EHHADH
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2b3c015c_f20c_4ba2_bc70_14ba26412cf8
initial concentration: NaN
boundary condition: true
is: P06576
is: SBO:0000252
name: ATP5B
has only substance units: false
initial amount: NaN
is encoded by: hsa:506
type: Species
constant: false

metaM but e
constant: false
name: butyrate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00039
initial amount: NaN
is: CHEBI:17968

http://identifiers.org/biomodels.db/MODEL1310110030#_d57a8d69_4e64_446e_a1d7_68a3d8340139
type: Species
initial amount: NaN
is encoded by: hsa:10861
has only substance units: false
constant: false
is: Q9H2B4
initial concentration: NaN
name: SLC26A1
boundary condition: true
is: SBO:0000252

metaR RE1796M
modifier: MODEL1310110030#
name: RE1796
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#

metaR LTA4H
type: Reaction
is described by: ECO:0000134
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.2.6
fast: false
modifier: MODEL1310110030#
name: Leukotriene A-4 hydrolase
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7770e793_2f79_4ca0_af90_cda3da380f09
name: PAFAH2
constant: false
is encoded by: hsa:5051
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: Q99487

http://identifiers.org/biomodels.db/MODEL1310110030#_2256140d_7e17_4aed_afc6_a56a876865c6
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: Q9BY49
name: PECR
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:55825

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_2aa9f9b5_38d5_443c_93cb_979c6305656a
boundary condition: true
is encoded by: hsa:BF195998
initial amount: NaN
type: Species
name: _BF195998_1_x
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7eeb5ba6_38d9_46e7_a674_f0b07a77cedc
is: SBO:0000252
initial amount: NaN
name: DGKD
boundary condition: true
constant: false
is encoded by: hsa:8527
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d4d8bb6d_430d_4d86_a300_2436a5b54512
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM chol c
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
name: Choline
boundary condition: false
is: HMDB00097
constant: false
is: CHEBI:15354
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR ASNALANaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110030#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_74c15b54_6a95_4d9d_84e8_abaade9f6f5d
initial amount: NaN
has only substance units: false
is encoded by: hsa:386757
is: SBO:0000252
constant: false
type: Species
name: SLC6A10P
initial concentration: NaN
boundary condition: true

metaM CE5236 c
initial concentration: 1.0
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
constant: false
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
is: CHEBI:28002
is: HMDB03952
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_e8ea5320_7eb7_4624_a483_404ec9ed549d
initial concentration: NaN
boundary condition: true
is: Q6ZMR3
constant: false
initial amount: NaN
name: LDHAL6A
type: Species
is encoded by: hsa:160287
is: SBO:0000252
has only substance units: false

metaR ACNAMlt
fast: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
is described by: ECO:0000269
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
reversible: true
name: N-acetylneuraminate transport into lysososme
product: MODEL1310110030#

metaM pyr c
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
constant: false
has only substance units: false
is: HMDB00243
type: Species
is: CHEBI:15361
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR ACGAMPM
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.3
modifier: MODEL1310110030#
reactant: MODEL1310110030#
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_622c61c4_7fc3_4c5d_b795_d5f4cdc83104
name: PYGL
is: SBO:0000252
initial concentration: NaN
constant: false
is: P06737
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5836

metaM dgtp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
is: HMDB01440
constant: false
name: dGTP
has only substance units: false
initial amount: NaN
is: C00286
type: Species
is: CHEBI:16497
initial concentration: 1.0
boundary condition: false

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_5eb264ee_0f7b_44b7_b7bc_ec74ca87758b
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: NDUFB3
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4709
is: Q6IB80

metaM hspg e
boundary condition: false
has only substance units: false
is: HMDB02259
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: heparan sulfate proteoglycan
is: CHEBI:32366

http://identifiers.org/biomodels.db/MODEL1310110030#_7e504caa_5f37_4bfe_842d_3f54a85e1a56
has only substance units: false
is: SBO:0000252
constant: false
name: B3GNT4
initial concentration: NaN
is: Q9C0J1
type: Species
is encoded by: hsa:79369
boundary condition: true
initial amount: NaN

metaM tag hs c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
name: triglyceride
is: CHEBI:17855
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r2127
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM g3pc c
is: CHEBI:16870
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: sn-Glycero-3-phosphocholine
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: HMDB00086
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_266b8689_a4e4_49c5_90e4_38467b642511
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: _NM_001929_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:NM 001929

metaM orot5p c
name: Orotidine 5'-phosphate
is: C01103
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00218
constant: false
initial concentration: 1.0
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: CHEBI:57538
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b879d6f2_a4a3_4164_80ea_c25b52016ce8
constant: false
is: Q53HM1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: UCKL1
is encoded by: hsa:54963
has only substance units: false
initial concentration: NaN

metaM dpcoa c
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00882
is: CHEBI:57328
is: HMDB01373
name: Dephospho-CoA
has only substance units: false
initial amount: NaN
constant: false

metaR r1571
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_e19f668a_f7e3_445a_981c_e9ba139dafc9
initial amount: NaN
boundary condition: true
name: UCK1
is: SBO:0000252
is encoded by: hsa:83549
is: Q5JT09
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaR CMPSAS
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.7.43
name: CMP sialic acid synthase
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110030#_e139b8a2_0638_4711_85e8_95f64fe846d6
is encoded by: hsa:8706
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q49AT3
type: Species
name: B3GALNT1
initial concentration: NaN
constant: false
has only substance units: false

metaR CYTK1n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
fast: false

metaR r2128
is: SBO:0000185
modifier: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110030#

metaR CYSTA
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110030#
name: cysteine transaminase
fast: false
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
is described by: ECO:0000304

metaR GCC2am
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
product: MODEL1310110030#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_de136c39_1100_46bb_a3c1_b4ea89a2bc5d
type: Species
name: CRAT
initial amount: NaN
constant: false
is: SBO:0000252
is: P43155
is encoded by: hsa:1384
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ac c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
initial amount: NaN
is: CHEBI:30089
type: Species
constant: false
boundary condition: false
name: acetate
has only substance units: false

metaR AMETtd
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
name: diffusion of S-Adenosyl-L-methionine
reversible: true
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110030#

metaM pyr e
is: CHEBI:15361
boundary condition: false
is: HMDB00243
initial amount: NaN
constant: false
initial concentration: 1.0
name: pyruvate
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_7663547b_1216_4ae7_992d_49e6b6875e6d
initial amount: NaN
has only substance units: false
is: Q14432
constant: false
initial concentration: NaN
name: PDE3A
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5139
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_229c1093_a169_4fbc_b932_e9c1f1c5c6a4
initial concentration: NaN
name: NDUFB2
is: H7C5B8
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110030#_3433e075_f4f6_4c80_954b_ec211964d3a0
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4729
type: Species
name: NDUFV2
has only substance units: false
is: P19404
boundary condition: true
initial amount: NaN

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110030#
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR PIPLC
product: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
is: SBO:0000176
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
reversible: false

metaM hs deg1 l
is: HMDB06254
is: SBO:0000247
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species
constant: false
name: heparan sulfate, degradation product 1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_df0c7c4c_fbab_46ff_8a4d_b4ff068a1872
name: SDHD
is: SBO:0000252
boundary condition: true
is: O14521
initial concentration: NaN
is encoded by: hsa:6392
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM h2o2 x
initial amount: NaN
initial concentration: 1.0
is: C00027
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: SBO:0000247
boundary condition: false
name: Hydrogen peroxide
has only substance units: false
is: HMDB03125
type: Species

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: CHEBI:57328
constant: false
boundary condition: false
has only substance units: false
is: C00882
name: Dephospho-CoA
initial amount: NaN
is: HMDB01373
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2369
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_d0513e7e_cfa4_4a82_a7d5_02915ef440a0
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:56953
is: Q9NPB1
name: NT5M
is: SBO:0000252

metaR r1574
kinetic law: MODEL1310110030#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#

metaR ORNt4m
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110030#
name: ornithine mitochondrial transport exchange with citruline
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
modifier: MODEL1310110030#
reversible: true

metaR GLUPRT
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.2.14
is described by: ECO:0000269
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110030#
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110030#

metaM ksi pre8 g
name: keratan sulfate I biosynthesis, precursor 8
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_b57e202c_5751_4447_870e_950ac0f6a24e
type: Species
is encoded by: hsa:3614
is: B3KRZ3
is: SBO:0000252
name: IMPDH1
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaR SQLSr
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
fast: false
reversible: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Squalene synthase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110030#_48d85f35_8371_46aa_808d_91b05b572491
constant: false
is encoded by: hsa:847
name: CAT
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: P04040
initial amount: NaN
has only substance units: false

metaR GLYCTO1p
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is version of: http://identifiers.org/ec-code/1.1.3.15
reversible: false
name: Glycolate oxidase, peroxisome
product: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_c7b46fef_91d0_41d7_94ab_74aee01b062d
initial concentration: NaN
is encoded by: hsa:80347
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q13057
is: SBO:0000252
type: Species
constant: false
name: COASY

metaR r1573
product: MODEL1310110030#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM mi14p c
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00968
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
has only substance units: false

metaM ac e
initial amount: NaN
is: CHEBI:30089
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
is: HMDB00042
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110030#_aeb80978_aef1_4f54_81f3_4e4c34b503b9
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI935189
initial concentration: NaN
constant: false
has only substance units: false
name: _AI935189_1_m
boundary condition: true

metaR r1576
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_33f5f148_5cc5_49cf_98f1_32afe79b0cb8
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:3098
boundary condition: true
constant: false
is: SBO:0000252
is: A8K7J7
name: HK1
initial concentration: NaN

metaR MECOALm
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
is described by: ECO:0000212
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_0a75fb70_93d2_4625_94f4_670ceebac157
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25841
has only substance units: false
name: ABTB2
constant: false
is: E9PRW7

metaM retinal cis 9 c
boundary condition: false
initial amount: NaN
is: HMDB01358
initial concentration: 1.0
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: all-trans-retinal

metaR S6TASE26ly
is described by: ECO:0000000
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM fum c
initial concentration: 1.0
is: CHEBI:29806
type: Species
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
is: SBO:0000247
is: HMDB00134
boundary condition: false
is: C00122
name: Fumarate
initial amount: NaN

metaM xol7a r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: 20-hydroxycholesterol
is: CHEBI:1296
is: HMDB01496
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_600505ab_e79b_40ca_a60a_dc9e33097533
is: SBO:0000252
initial concentration: NaN
name: PDE1A
boundary condition: true
constant: false
type: Species
is: Q9Y633
is encoded by: hsa:5136
has only substance units: false
initial amount: NaN

metaR r1575
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_44420747_c9bf_46df_98df_0580bf9a05ad
is: Q53YB7
is encoded by: hsa:1329
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: COX5B
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_e999ef55_b042_459e_8b14_ae88e20b7c07
is encoded by: hsa:51166
is: Q4W5N8
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: AADAT
is: SBO:0000252

metaR ALAtN1
name: Alanine transport (Na, H coupled)
reversible: true
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110030#
modifier: MODEL1310110030#

metaR GSNt
is: SBO:0000185
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
type: Reaction
fast: false
name: guanosine facilated transport in cytosol
reactant: MODEL1310110030#

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
reactant: MODEL1310110030#

metaR EX CE5787 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_451d36dc_23ea_4f17_aa76_557a3ac3d558
has part: Q13454
has part: O95139
is encoded by: hsa:4700
has part: O95167
is encoded by: hsa:4729
is encoded by: hsa:4704
has part: P03905
has part: O95168
is encoded by: hsa:126328
has part: A8K761
type: Species
is encoded by: hsa:4731
is encoded by: hsa:4540
boundary condition: true
has part: Q6IB80
has part: Q16795
has part: Q9Y6M9
is encoded by: hsa:4535
is encoded by: hsa:4539
is encoded by: hsa:55967
is encoded by: hsa:4706
is encoded by: hsa:7991
is encoded by: hsa:4697
has part: Q6IBB5
has part: Q7GXZ4
has part: O00483
is encoded by: hsa:4694
has part: P03897
is encoded by: hsa:4709
is encoded by: hsa:4719
is encoded by: hsa:4714
is encoded by: hsa:4724
is encoded by: hsa:51079
is encoded by: hsa:4701
is encoded by: hsa:4711
is encoded by: hsa:4705
is encoded by: hsa:4715
has part: Q9P0J0
has part: O75489
has part: O75251
has part: H7C5B8
has part: F8VQS7
is encoded by: hsa:4717
is encoded by: hsa:4722
has part: O95299
has only substance units: false
is encoded by: hsa:4536
is encoded by: hsa:4725
has part: O14561
has part: O43678
has part: O75438
is encoded by: hsa:4537
is encoded by: hsa:4695
has part: Q16718
is encoded by: hsa:4698
has part: P03915
has part: E5KNH5
has part: Q7GXY9
is encoded by: hsa:4707
has part: O43677
is encoded by: hsa:4702
is encoded by: hsa:4712
is encoded by: hsa:4716
has part: Q549M5
has part: P19404
initial concentration: NaN
is encoded by: hsa:4541
has part: O95169
has part: Q6FG42
has part: P56556
is encoded by: hsa:4718
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4728
has part: P56181
has part: O43181
has part: Q7GXZ1
has part: B1AM93
is encoded by: hsa:4696
is encoded by: hsa:4710
is encoded by: hsa:4720

metaR r1578
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dmpp x
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57623
is: SBO:0000247
boundary condition: false
type: Species
name: prenyl diphosphate(3-)
is: HMDB01120

http://identifiers.org/biomodels.db/MODEL1310110030#_08cbcdbe_8903_48e7_9261_dca24930f603
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: B4DG68
boundary condition: true
has only substance units: false
type: Species
name: NOS1
is encoded by: hsa:4842

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM ksii core4 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
is: SBO:0000247
boundary condition: false
is: CHEBI:58053
is: C00130
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
type: Species
is: HMDB00175
initial amount: NaN

metaR biomass reaction
reactant: MODEL1310110030#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
name: biomass_reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_352675d9_9781_4cc8_bf62_61adaf91b695
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P23786
is encoded by: hsa:1376
initial amount: NaN
constant: false
name: CPT2
boundary condition: true

metaM cs e deg4 l
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H46NO38S4 CHARGE: -5
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
has only substance units: false
is: CHEBI:15748
constant: false
is: HMDB00127
type: Species

metaR PYRt2r
is: SBO:0000185
modifier: MODEL1310110030#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
fast: false

metaR PAFS
name: alkyl glycerol phosphocholine acetyl transferase
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
reversible: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_85a18821_2459_46b8_84e2_e844ce36a86d
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:501
initial concentration: NaN
name: ALDH7A1
is: SBO:0000252
is: E7EPT3
type: Species
initial amount: NaN

metaM cspg e l
is: CHEBI:36005
type: Species
initial amount: NaN
is: HMDB02183
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
has only substance units: false
constant: false

metaR GULN3D
name: L-gulonate 3-dehydrogenase
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176

metaM dgtp e
constant: false
name: dGTP
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16497
boundary condition: false
initial amount: NaN
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_35d88e90_c2d9_47a0_9ce5_3bcd66f9fb3b
name: TPH2
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:121278
initial amount: NaN
type: Species
initial concentration: NaN
is: Q8IWU9

metaR r0629
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.22
kinetic law: MODEL1310110030#

metaR r2376
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_ce082066_a685_4bcf_84d2_bf36f9d5b5ab
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:3423
name: IDS
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P22304

metaR r2132
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
type: Reaction

metaM pheacgln c
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false
initial amount: NaN
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
is: HMDB06344
is: CHEBI:58310
type: Species
has only substance units: false
is: SBO:0000247

metaR GASNASE3ly
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_9d770e20_2358_4581_b3fa_f1ebff3702c4
type: Species
name: CLYBL
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:171425
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8d14f30e_8aa9_47e1_bc0f_dde3679b2803
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: ALDH4A1
is encoded by: hsa:8659
initial concentration: NaN
initial amount: NaN
constant: false

metaR r2375
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9c32a583_278e_4af4_bd59_3291b804ad3f
is: SBO:0000252
name: PIGW
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:284098
is: Q7Z7B1
boundary condition: true
has only substance units: false

metaM ksi deg17 l
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 17
is: HMDB00143
initial amount: NaN
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
has only substance units: false
constant: false
is: SBO:0000247

metaR G14T11g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110030#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR r2131
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110030#
type: Reaction
fast: false
reactant: MODEL1310110030#

metaM HC02214 c
boundary condition: false
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
is: CHEBI:28852
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_b7ec2b1b_31ef_4540_a449_92c5b1ecd81c
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2983
is: Q02153
initial concentration: NaN
constant: false
type: Species
name: GUCY1B3

metaM HC01410 m
is: SBO:0000247
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706

metaM sql r
boundary condition: false
type: Species
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
has only substance units: false
is: CHEBI:15440
initial amount: NaN
is: SBO:0000247
name: squalene
is: HMDB00256
initial concentration: 1.0
constant: false

metaR r1428
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110030#
name: Free diffusion
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110030#

metaM hista e
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
name: histamium
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00870
has only substance units: false
initial amount: NaN

metaM ksi deg2 l
is: HMDB02177
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
name: keratan sulfate I, degradation product 2
is: CHEBI:36033
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_0d65e61e_9759_4619_969c_2025171dc871
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: P49902
initial amount: NaN
name: NT5C2
constant: false
initial concentration: NaN
is encoded by: hsa:22978

metaM dgtp c
is: HMDB01440
name: dGTP
type: Species
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:16497
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_9add310d_02f1_4c63_8135_83c5a2893006
name: RPN2
is encoded by: hsa:6185
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: P04844
type: Species

metaM dcmp n
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB01202
has only substance units: false
is: CHEBI:57566
is: SBO:0000247
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)

metaR r2374
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110030#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
is: SBO:0000185
name: Choline transport, nuclear through pores
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
product: MODEL1310110030#

metaM udp c
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00015
constant: false
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
type: Species
is: HMDB00295
name: UDP

http://identifiers.org/biomodels.db/MODEL1310110030#_17553a6a_1e0d_466f_8dbc_f772fba6bbaf
type: Species
name: CEPT1
initial amount: NaN
is: SBO:0000252
is: B3KN25
is encoded by: hsa:10390
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Free diffusion
fast: false
is: SBO:0000185

metaR r0345
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true

metaM pyr m
is: C00022
is: HMDB00243
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
constant: false
is: CHEBI:15361
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR DCYTD
name: deoxycytidine deaminase
is described by: ECO:0000254
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176

metaR r2373
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00973
constant: false
has only substance units: false
name: hydrogenphosphate
is: CHEBI:43474
boundary condition: false
initial amount: NaN
is: C00009

http://identifiers.org/biomodels.db/MODEL1310110030#_94de0a8d_54f0_45e7_a2a9_49e9eaed59d0
boundary condition: true
is: SBO:0000252
name: G6PD
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2539
is: P11413

http://identifiers.org/biomodels.db/MODEL1310110030#_0424d8e4_78e4_4c39_b4d5_46054a2bfe27
is: P40879
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SLC26A3
boundary condition: true
is encoded by: hsa:1811
type: Species

metaM ksi deg5 l
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 5
has only substance units: false

metaR r2133
product: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_476cbea6_9d58_4f58_ba93_6e4708d1de75
initial amount: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:D29675
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _D29675_1_e

http://identifiers.org/biomodels.db/MODEL1310110030#_853e07f3_8778_40d2_b22e_719e28faffa9
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NSC7
has only substance units: false
is encoded by: hsa:55808
name: ST6GALNAC1
constant: false
initial concentration: NaN
boundary condition: true

metaM hista c
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
is: CHEBI:58432
boundary condition: false
initial concentration: 1.0
is: HMDB00870
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM em2emgacpail prot hs r
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
is: HMDB00086
is: CHEBI:16870
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR CHOLtu
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
name: Choline uniport
reactant: MODEL1310110030#

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110030#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#

metaM xoltetrol m
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17278
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110030#
type: Reaction
fast: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III

http://identifiers.org/biomodels.db/MODEL1310110030#_a3752c97_adc3_4131_8f1d_a956c1507541
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3176
name: HNMT
initial concentration: NaN
is: SBO:0000252
type: Species
is: P50135
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b96cb319_c8be_4882_8d6a_7643f6323793
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PAPSS1
is: SBO:0000252
is encoded by: hsa:9061
type: Species
constant: false
is: O43252

metaR GLBRAN
is version of: http://identifiers.org/ec-code/2.4.1.18
notes: GENE_ASSOCIATION: (2632.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.18 Confidence Level: 4 AUTHORS: PMID:8463281 NOTES:NCD
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
name: 1,4-alpha-glucan branching enzyme (glygn1 -> glygn2)
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaM succoa m
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57292
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
constant: false
has only substance units: false
name: Succinyl-CoA
is: SBO:0000247
is: HMDB01022

metaR r2379
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

metaR PYRt2m
reversible: true
modifier: MODEL1310110030#
fast: false
name: pyruvate mitochondrial transport via proton symport
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_897cfc3e_2791_470a_8d9c_14330c4a39f0
constant: false
type: Species
boundary condition: true
is encoded by: hsa:3417
initial amount: NaN
is: SBO:0000252
name: IDH1
initial concentration: NaN
is: O75874
has only substance units: false

metaM hs deg16 l
initial concentration: 1.0
is: CHEBI:21338
is: HMDB02704
initial amount: NaN
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
constant: false
type: Species
name: heparan sulfate, degradation product 16
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1580
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110030#
fast: false
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true

metaM pi m
has only substance units: false
name: hydrogenphosphate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00009
type: Species
boundary condition: false
constant: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474

metaR GluForTx
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.1.2.5
name: Glutamate formimidoyltransferase
fast: false
modifier: MODEL1310110030#

metaR r2378
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1078
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
fast: false
product: MODEL1310110030#
is: SBO:0000185
name: Vesicular transport
is described by: ECO:0000000
reversible: false

metaR TREHe
is version of: http://identifiers.org/ec-code/3.2.1.28
name: alpha,alpha-trehalase
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_48680c9b_f524_48db_9c63_69d3b77ead37
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: GCK
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2645

metaR APAT2rm
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000212
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
fast: false

metaM nmn c
has only substance units: false
name: NMN
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
type: Species
is: HMDB00229
is: SBO:0000247
is: CHEBI:14649
is: C00455
constant: false
boundary condition: false

metaR DESAT20 2
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
kinetic law: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_43da56c7_b2ad_49c1_a245_e8852d292840
constant: false
is: SBO:0000252
is: Q96AT9
has only substance units: false
is encoded by: hsa:6120
name: RPE
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM pheacgln e
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58310
type: Species
initial concentration: 1.0
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false
is: HMDB06344

metaM udp g
initial amount: NaN
is: HMDB00295
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:58223
boundary condition: false
constant: false

metaR r1581
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2377
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_654f1508_10e5_4bac_8567_20641a37748c
boundary condition: true
is encoded by: hsa:6391
is: Q99643
is: SBO:0000252
initial concentration: NaN
constant: false
name: SDHC
initial amount: NaN
has only substance units: false
type: Species

metaM pi n
boundary condition: false
is: HMDB00973
is: SBO:0000247
initial amount: NaN
is: CHEBI:43474
type: Species
constant: false
name: hydrogenphosphate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR r2137
reactant: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR DESAT20 1
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176

metaR GLYCLTtp
fast: false
reversible: false
name: glycolate transport into peroxisome
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_51634b21_ee0c_4e37_a805_5551c004d4b6
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: PDE9A
constant: false
boundary condition: true
is encoded by: hsa:5152
has only substance units: false

metaR r0494
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
fast: false
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM HC02214 e
constant: false
has only substance units: false
is: CHEBI:28852
type: Species
name: prostaglandin-f1alpha
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_3c1f3112_80ed_45d9_91e3_978ed8447f24
initial concentration: NaN
is encoded by: hsa:H45672
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _H45672_1_m

http://identifiers.org/biomodels.db/MODEL1310110030#_88929c3b_f141_47b2_b7ea_a6c49c8ff669
constant: false
is encoded by: hsa:761
initial concentration: NaN
name: CA3
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P07451

metaR ALADGLYexR
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
name: D-alanine/glycine reversible exchange
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_3daa057b_b372_462c_91b0_84ee9b56fc11
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: CPT1B
is: E9PCP2
boundary condition: true
is encoded by: hsa:1375
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_dcdf2e47_4bdd_471c_81a8_2fa19fcad9f6
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _HG2846_HT2983_1_m
initial amount: NaN
has only substance units: false

metaM b2coa m
initial concentration: 1.0
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial amount: NaN
boundary condition: false
name: crotonoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57332
constant: false
is: HMDB02009
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_53d32f80_29a2_4233_8aa1_1c78790b460f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51805
boundary condition: true
constant: false
name: COQ3
type: Species
initial amount: NaN
has only substance units: false
is: Q9NZJ6

metaM alpam m
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: HMDB06239
name: S-aminomethyldihydrolipoamide
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_4d42f4fe_a20d_410f_8d95_bbbe041491a6
type: Species
has only substance units: false
is: C9JZ62
boundary condition: true
initial concentration: NaN
is encoded by: hsa:641649
initial amount: NaN
constant: false
is: SBO:0000252
name: TMEM91

metaR r0340
modifier: MODEL1310110030#
fast: false
reversible: false
kinetic law: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/1.3.1.38

metaM 2dpmhobq m
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
boundary condition: false
initial amount: NaN
is: CHEBI:50771
is: HMDB06484
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
has only substance units: false

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
is: CHEBI:43474
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5a6e932a_70c0_4f5c_84b8_87d8075a9924
is: Q674R7
name: ATG9B
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:285973
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_096c5836_7e40_4230_9012_bbe8cf75d768
constant: false
has only substance units: false
is encoded by: hsa:23007
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: PLCH1
is: Q4KWH8

metaM cbasp c
initial amount: NaN
is: HMDB00828
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: CHEBI:32814
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
is: C00438
initial concentration: 1.0

metaR NADHtru
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: NADH transporter, endoplasmic reticulum
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaM ksii core2 deg4 l
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16953
name: keratan sulfate II (core 2-linked), degradation product 4
is: HMDB00812
notes: FORMULA: C58H95N5O43SX CHARGE: -1

metaM CE5236 n
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
constant: false
is: HMDB03952
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28002
boundary condition: false

metaM CE1935 e
name: spermine monoaldehyde
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:52324
constant: false

metaM leuktrE4 c
boundary condition: false
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02200

metaM dcmp c
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: dCMP
is: C00239
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
has only substance units: false
is: CHEBI:57566

metaR DITPtn
is described by: ECO:0000000
name: dITP nuclear transport
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110030#

metaR RE1796R
type: Reaction
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
product: MODEL1310110030#
name: RE1796
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
modifier: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_29edb407_6796_49d7_a343_3cf77bad9bfb
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5052
has only substance units: false
name: PRDX1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM ahcys m
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
initial amount: NaN
type: Species
name: S-Adenosyl-L-homocysteine
boundary condition: false
is: CHEBI:16680
is: C00021
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r2029
product: MODEL1310110030#
is: SBO:0000185
modifier: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reversible: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR GTHP
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.11.1.15
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000134
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.11.1.9
reversible: true
name: glutathione peroxidase

metaM cs e deg6 l
initial amount: NaN
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
boundary condition: false
type: Species
is: CHEBI:16953
is: HMDB00812
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM cs a deg3 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: HMDB00127
constant: false
initial amount: NaN
type: Species
is: CHEBI:15748
initial concentration: 1.0
boundary condition: false

metaR ACNACNGALGBSIDEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
reactant: MODEL1310110030#
type: Reaction
name: acnacngalgbside hs transport
kinetic law: MODEL1310110030#
product: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: true

metaR GLCt1r
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
kinetic law: MODEL1310110030#
name: glucose transport (uniport)
fast: false
product: MODEL1310110030#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaM cbasp e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
type: Species
is: SBO:0000247
is: CHEBI:32814
is: C00438
initial amount: NaN
is: HMDB00828
name: N-Carbamoyl-L-aspartate

metaR THBPT4ACAMDASE
is described by: ECO:0000269
fast: false
product: MODEL1310110030#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reversible: false
kinetic law: MODEL1310110030#

metaM udp l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58223
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: HMDB00295
boundary condition: false
name: UDP(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5125fd5b_e758_44fd_9730_fb41acc41a03
is: SBO:0000252
is encoded by: hsa:5335
name: PLCG1
is: Q9UFY1
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_760abb65_ef3a_4829_bd50_1f78ace6fb8c
name: GALNTL2
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:117248
is: Q8N3T1
initial amount: NaN

metaR 3HCO3 NAt
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is described by: ECO:0000134
type: Reaction
fast: false
name: 3HCO3_NAt
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#

metaR CRNCARtp
type: Reaction
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: carnitine-acetylcarnitine carrier, peroxisomal
reactant: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_3a227da4_e7f7_488a_859f_adf35df0d946
name: ACAD9
constant: false
is: Q9H845
type: Species
is: SBO:0000252
is encoded by: hsa:28976
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM fru c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00660
is: CHEBI:15824
boundary condition: false
constant: false
is: C00095
is: SBO:0000247
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_b2156a95_98ad_4452_88d2_6dc1d05eead2
is: Q8IUC8
has only substance units: false
name: GALNT13
is encoded by: hsa:114805
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaM lald D c
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
name: (R)-lactaldehyde
is: SBO:0000247
is: CHEBI:17167
has only substance units: false
type: Species
initial concentration: 1.0

metaR P45046A1r
name: cytochrome P450, family 46, subfamily A, polypeptide 1
modifier: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
type: Reaction
reversible: false
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10858.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.98
kinetic law: MODEL1310110030#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r2372
reactant: MODEL1310110030#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_528c07b2_99aa_48ae_ac98_b1505417089f
has only substance units: false
is encoded by: hsa:48
is: SBO:0000252
is: P21399
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: ACO1

metaM adprbp e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
is: HMDB06336
type: Species
initial amount: NaN
boundary condition: false
name: ADP-D-ribose 2'-phosphate(4-)
constant: false
initial concentration: 1.0
is: CHEBI:58673

metaR AHCYSte
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is: SBO:0000185
fast: false
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110030#
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_434421fd_3571_49ae_a304_0c106ec26797
is encoded by: hsa:178
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: AGL
type: Species
is: SBO:0000252
boundary condition: true

metaM pail34p hs c
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
is: CHEBI:57658
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_caa3bb2f_7f19_4f97_beaf_d2ed8ab2e582
initial concentration: NaN
is encoded by: hsa:2746
has only substance units: false
initial amount: NaN
boundary condition: true
is: E9KL48
type: Species
name: GLUD1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_29246a9c_3c7e_41cb_b55c_bcbe24ad99d5
is: Q99944
has only substance units: false
boundary condition: true
name: EGFL8
is: SBO:0000252
is encoded by: hsa:80864
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaM CE2705 c
initial concentration: 1.0
name: quinonoid dihydrobiopterin
type: Species
constant: false
is: SBO:0000247
is: CHEBI:36781
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_b6204e82_baa7_4f5b_a6ee_ecaa13984a29
is: P23786
has only substance units: false
is encoded by: hsa:1376
boundary condition: true
name: CPT2
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaM pi c
is: CHEBI:43474
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2
type: Species
has only substance units: false
is: C00009
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: hydrogenphosphate
is: SBO:0000247

metaM acngalgbside hs g
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
type: Species
constant: false
boundary condition: false
is: HMDB03406
initial amount: NaN
has only substance units: false
name: sialyl galactosylgloboside
initial concentration: 1.0
is: CHEBI:16523
is: SBO:0000247

metaR NDPK3n
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000304
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_d55d51c5_261b_4dd9_8335_748d67cafbd7
name: HKDC1
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:80201
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: B3KT70

http://identifiers.org/biomodels.db/MODEL1310110030#_9202da85_e59a_4364_911a_a0161985cda8
has part: P36542
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: A8K092
is encoded by: hsa:498
has part: P56381
is: SBO:0000297
has only substance units: false
is encoded by: hsa:509
is encoded by: hsa:514
type: Species
initial concentration: NaN
is encoded by: hsa:513
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:506
has part: P30049
has part: P06576

metaM cs e deg5 l
initial amount: NaN
constant: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: CHEBI:57737
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00868
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5

metaR ADPRIBt
fast: false
is version of: http://identifiers.org/ec-code/3.2.2.5
product: MODEL1310110030#
type: Reaction
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
name: ADPribose transport
reversible: false

metaM udp n
initial concentration: 1.0
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58223
type: Species

metaM h2o2 e
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
boundary condition: false
initial concentration: 1.0
is: CHEBI:16240
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaR r2371
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_cd98f03a_9c74_440c_9faf_f65fca6c16a7
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10632
type: Species
initial amount: NaN
name: ATP5L
boundary condition: true
is: O75964
initial concentration: NaN
constant: false

metaM ksii core4 deg1 l
name: keratan sulfate II (core 4-linked), degradation product 1
is: SBO:0000247
is: HMDB00868
initial concentration: 1.0
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57737

metaR ADEt
reversible: true
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: adenine reversible transport, cytosol
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110030#

metaR MI14P4P
kinetic law: MODEL1310110030#
fast: false
reversible: false
name: inositol-1,4-bisphosphate 4-phosphatase
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR r2130
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110030#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_49b6b416_d46a_488e_833b_c016de8e06e1
initial amount: NaN
type: Species
is: Q9BWD1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACAT2
constant: false
is encoded by: hsa:39
has only substance units: false

metaR r0051
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110030#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
kinetic law: MODEL1310110030#
fast: false

metaR EX aprgstrn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 20alpha-Hydroxyprogesterone exchange
type: Reaction

metaR S6TASE13ly
is: SBO:0000176
modifier: MODEL1310110030#
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction

metaM ksii core2 l
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB01014
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate II (core 2-linked)
has only substance units: false
is: CHEBI:57255

metaR S4TASE4ly
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.12
reversible: true

metaR GLYt7 311 r
modifier: MODEL1310110030#
is described by: ECO:0000006
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reversible: true
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
name: glycine reversible transport via sodium and chloride symport (3:1:1)

metaR CYTDt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: cytidine facilated transport in cytosol
is: SBO:0000185
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction

metaR r0627
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR GLUTCOADHm
is described by: ECO:0000304
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
modifier: MODEL1310110030#
name: glutaryl-CoA dehydrogenase (mitochondria)
is: SBO:0000176
product: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
fast: false

metaM pi e
constant: false
is: CHEBI:43474
is: SBO:0000247
has only substance units: false
boundary condition: false
name: hydrogenphosphate
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
initial concentration: 1.0
is: C00009
type: Species

metaR ARACHDtr
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
reversible: true
name: intracellular transport
type: Reaction
reactant: MODEL1310110030#

metaR HMGCOARc
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110030#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
modifier: MODEL1310110030#

metaM h2o2 c
initial amount: NaN
is: CHEBI:16240
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00027
boundary condition: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125

metaM ksi deg39 l
initial concentration: 1.0
type: Species
notes: FORMULA: C48H81N3O36 CHARGE: 0
constant: false
is: HMDB00143
name: keratan sulfate I, degradation product 39
initial amount: NaN
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_7ba4cd90_92d4_47d6_bccb_1e8ed16727e2
type: Species
name: _X63359_1_c
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:X63359
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_38e326f0_1215_4976_ad0b_245a918c2fa2
has only substance units: false
initial concentration: NaN
is: Q1EHB4
is encoded by: hsa:159963
is: SBO:0000252
name: SLC5A12
constant: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_99216dd5_38f5_4242_8d99_a392f62850a7
is encoded by: hsa:10559
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P78382
has only substance units: false
name: SLC35A1

metaR CRNtx
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
kinetic law: MODEL1310110030#
name: carnitine transport peroxisome to mitochondria
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
fast: false
reversible: true

metaM mi134p c
is: HMDB01143
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial concentration: 1.0
has only substance units: false
is: CHEBI:58414
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
type: Species

metaR ASAH1
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.5.1.23
type: Reaction
fast: false
reversible: false
name: N-acylsphingosine amidohydrolase
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM ppcoa c
type: Species
initial concentration: 1.0
is: CHEBI:57392
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
is: HMDB01275
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_124dc939_d4f2_4f8b_8e6c_cde45017888c
initial concentration: NaN
is encoded by: hsa:4831
has only substance units: false
is: P22392
is: SBO:0000252
constant: false
name: NME2
boundary condition: true
type: Species
initial amount: NaN

metaM dtdp e
type: Species
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
initial amount: NaN
is: HMDB01274
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110030#_f2d72ba6_c0e0_4659_8612_148d55010f2d
initial concentration: NaN
type: Species
has only substance units: false
is: O95168
initial amount: NaN
is: SBO:0000252
name: NDUFB4
constant: false
boundary condition: true
is encoded by: hsa:4710

metaM leuktrA4 e
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species
initial concentration: 1.0
is: HMDB01337
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57463
name: leukotriene A4(1-)

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM tdchola c
initial amount: NaN
initial concentration: 1.0
name: taurochenodeoxycholate
type: Species
is: HMDB00951
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
boundary condition: false
is: CHEBI:9407

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate
is: CHEBI:34306
initial amount: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9b556882_84e1_46df_8f78_6dd37f5c1f72
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O94778
has only substance units: false
is encoded by: hsa:343
boundary condition: true
constant: false
type: Species
name: AQP8

metaM pail345p hs c
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: CHEBI:57836
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981

metaM gmp g
initial amount: NaN
boundary condition: false
name: GMP(3-)
constant: false
initial concentration: 1.0
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false

metaR ARACHCRNt
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_af0bcc93_d935_4809_8aa3_8948f1082bf1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI934540
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI934540_1_c

metaR S23T3g
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.6
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a41b9044_6585_4a9b_8e95_fec46ad94311
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2222
name: FDFT1
type: Species
is: P37268
initial amount: NaN
initial concentration: NaN

metaR r0774
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is: SBO:0000176

metaM glyc c
constant: false
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: Glycerol
is: C00116
is: CHEBI:17754
is: HMDB00131
boundary condition: false

metaR NACHEX22ly
reactant: MODEL1310110030#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110030#

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
is: SBO:0000176
product: MODEL1310110030#
reversible: true
name: adentylate kinase (GTP)
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
modifier: MODEL1310110030#

metaM HC02213 e
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:28031
name: prostaglandin-e3
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

http://identifiers.org/biomodels.db/MODEL1310110030#_8a6aae56_a91a_4f6e_9e1f_1ece5880f7d5
initial concentration: NaN
is: SBO:0000252
is: Q86SK9
boundary condition: true
constant: false
has only substance units: false
name: SCD5
initial amount: NaN
is encoded by: hsa:79966
type: Species

metaM nad e
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
name: NAD(1-)
is: CHEBI:57540
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM 9 cis retfa e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB06559
is: SBO:0000247
constant: false
boundary condition: false
name: fatty acid 9-cis-retinol

metaR DOLDPP Ler
reversible: false
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.6.1.43
is described by: ECO:0000000
modifier: MODEL1310110030#

metaR OCCOAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110030#
name: fatty acid intracellular transport
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false

metaR RE0566C
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0566
reversible: true

metaM ksi deg40 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 40
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00143
initial concentration: 1.0

metaM dtdp c
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
is: HMDB01274
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58369
name: dTDP
has only substance units: false
is: C00363

metaR OCD11CRNCACT
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM ksi pre25 g
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 25
is: CHEBI:58053
is: SBO:0000247
type: Species
is: HMDB00175
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C199H319N14O163S7X CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110030#_5976ecf2_e66a_4867_b723_ef1b5b0667c3
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:23057
has only substance units: false
boundary condition: true
is: Q9BZQ4
name: NMNAT2
is: SBO:0000252

metaM 2dp6mobq m
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
boundary condition: false
is: CHEBI:50773
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM 5adtststerones c
boundary condition: false
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
constant: false
has only substance units: false

metaM tdchola e
initial concentration: 1.0
is: HMDB00951
type: Species
name: taurochenodeoxycholate
is: SBO:0000247
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
initial amount: NaN
is: CHEBI:9407
boundary condition: false

metaM m5masnC g
is: CHEBI:58282
initial amount: NaN
is: HMDB00968
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
type: Species
notes: FORMULA: C52H87N2O40X CHARGE: 0
constant: false

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
is: SBO:0000247
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:34306
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_c22725f7_6b3e_479a_87e6_b82bba256ac8
constant: false
is: E9PD84
initial concentration: NaN
is encoded by: hsa:9468
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: PCYT1B

metaM ahcys c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
boundary condition: false
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
initial amount: NaN
is: HMDB00939
is: C00021
is: SBO:0000247

metaR ADK1m
is described by: ECO:0000269
product: MODEL1310110030#
name: adenylate kinase, mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_1f0e259b_b2d6_4dba_9cd0_0b1907adeec8
type: Species
is: Q546Y9
has only substance units: false
name: AICDA
constant: false
is encoded by: hsa:57379
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_f3d87566_be17_4311_81f0_9547d5aa8ed7
is: SBO:0000252
name: NOS3
boundary condition: true
initial concentration: NaN
type: Species
is: A0S0A7
is encoded by: hsa:4846
has only substance units: false
initial amount: NaN
constant: false

metaM nad c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
is: SBO:0000247
is: C00003
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00902
initial amount: NaN
type: Species

metaM glyc e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
is: C00116
type: Species
is: HMDB00131
is: CHEBI:17754
name: Glycerol
has only substance units: false
boundary condition: false
constant: false

metaR r0360
reversible: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110030#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaR HS2ly
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
name: heparan-N-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_971f3612_bf8b_4441_bff7_d9e6bc29c776
name: ATP5F1
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:515
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d948fa0e_a831_4dbc_9aeb_e410ea8d002b
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728441
constant: false
is: SBO:0000252
name: GGT2
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d700f572_4d37_454c_bd0f_f492bacb1b25
initial amount: NaN
is: Q16718
initial concentration: NaN
is encoded by: hsa:4698
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NDUFA5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_3323c90b_df2b_4a5b_b247_6ac1e446c714
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10786
name: SLC17A3
boundary condition: true
is: O00476
constant: false
initial concentration: NaN
has only substance units: false

metaM ocdcea e
initial concentration: 1.0
type: Species
name: octadecenoate (n-C18:1)
is: SBO:0000247
is: CHEBI:0
initial amount: NaN
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110030#_e8626ee2_8a26_4c7a_99b6_85c53a24a2e3
has only substance units: false
is: Q9BWD1
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACAT2
initial amount: NaN
is encoded by: hsa:39
constant: false

metaM 2mcit c
type: Species
name: 2-methylcitrate(3-)
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: CHEBI:15598
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00379

metaR AHCYStd
type: Reaction
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
name: diffusion of S-Adenosyl-L-homocysteine
fast: false
is described by: ECO:0000134

metaM cspg a e
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
type: Species
has only substance units: false
constant: false
is: CHEBI:16040
initial concentration: 1.0
is: SBO:0000247
is: HMDB00630
boundary condition: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR ALAASNNaEx
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110030#
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110030#

metaR MM7Cbg
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_23b33448_6ea8_4c4d_8703_3194fc005aea
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: ALDH1A1
is: P00352
is encoded by: hsa:216
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_81af8308_cb26_467d_b173_f3db2f9eea10
is encoded by: hsa:23475
constant: false
is: SBO:0000252
is: Q15274
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: QPRT
initial amount: NaN

metaM 5adtststerones e
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06278
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_99bf2ef2_d420_4b20_b4d7_b55246ed38a8
type: Species
constant: false
name: PLCZ1
is: SBO:0000252
is: Q86YW0
is encoded by: hsa:89869
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cf8ea50e_c241_44c5_acc7_d20ac1576d10
has only substance units: false
constant: false
initial concentration: NaN
name: COQ2
boundary condition: true
is encoded by: hsa:27235
is: Q96H96
initial amount: NaN
is: SBO:0000252
type: Species

metaM lnlnca l
initial concentration: 1.0
is: SBO:0000247
name: alpha-linolenate
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
boundary condition: false
is: CHEBI:32387
constant: false
is: HMDB01388

metaR AKR1C42
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269

metaM gmp c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58115
initial amount: NaN
name: GMP
type: Species
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: C00144
constant: false

metaM ahcys e
has only substance units: false
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: HMDB00939
name: S-Adenosyl-L-homocysteine
boundary condition: false
is: C00021
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaR DURIt
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
name: deoxyuridine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_4b2b366b_55a7_4199_8c1c_f54e8713d66d
initial concentration: NaN
type: Species
is: Q16795
constant: false
initial amount: NaN
is encoded by: hsa:4704
boundary condition: true
name: NDUFA9
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_9d5cce06_2829_494e_b0ab_20acc4e38b35
is: SBO:0000252
is: Q6NZ59
boundary condition: true
name: ATP5J
initial concentration: NaN
is encoded by: hsa:522
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02183
has only substance units: false
name: cervonic acid, C22:6 n-3
constant: false
type: Species
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110030#_02eebf0a_0773_42ab_ab2f_f4d046b431fd
initial concentration: NaN
constant: false
is encoded by: hsa:204
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AK2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5399d99c_77be_454f_9135_d8df17eea55d
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:89874
name: SLC25A21
has only substance units: false
initial concentration: NaN
is: G3V4L5
type: Species
initial amount: NaN

metaR GLCNACPT L
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.15
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_431a1a53_2107_4e60_a790_8eb97743df5b
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC9A5
constant: false
is: SBO:0000252
boundary condition: true
is: Q9NSW9
is encoded by: hsa:6553

metaM xyl D l
has only substance units: false
name: aldehydo-D-xylose
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:15936

metaM arachd x
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
is: SBO:0000247
is: HMDB01043
is: CHEBI:32395
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaM ocdcea c
is: HMDB00207
initial concentration: 1.0
name: octadecenoate (n-C18:1)
type: Species
is: CHEBI:0
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
is: C00712
has only substance units: false
boundary condition: false
constant: false

metaM udp r
name: UDP
is: HMDB00295
type: Species
boundary condition: false
is: C00015
is: CHEBI:58223
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
initial concentration: 1.0

metaR ASPGLUm
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: aspartate-glutamate mitochondrial shuttle
fast: false
reversible: true
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269

metaR PTCRTD
kinetic law: MODEL1310110030#
name: diffusion of putriscine into the endothelial cells
is: SBO:0000185
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
is described by: ECO:0000134
type: Reaction

metaR HS1ly
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM btn e
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: C00120
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
boundary condition: false
initial amount: NaN
is: HMDB00030
name: Biotin

http://identifiers.org/biomodels.db/MODEL1310110030#_805e89d7_16d0_4ad7_9f0a_cfeb5d45066b
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:1854
is: P33316
constant: false
initial amount: NaN
name: DUT
boundary condition: true
initial concentration: NaN

metaR HEX7
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110030#
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
type: Reaction
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR NACHEX2ly
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110030#
modifier: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR ABUTt2r
reversible: true
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000304
name: 4-aminobutyrate reversible transport in via proton symport
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaM gmp e
initial concentration: 1.0
name: GMP(3-)
initial amount: NaN
constant: false
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
boundary condition: false
type: Species

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_51d89576_ec4f_49de_a7b8_8aab37847bf2
is encoded by: hsa:81031
is: O95528
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: SLC2A10

http://identifiers.org/biomodels.db/MODEL1310110030#_5f9fdea6_eeb2_4cfa_977f_b4621ea354ab
type: Species
boundary condition: true
name: PIGO
initial concentration: NaN
constant: false
is encoded by: hsa:84720
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_36f171c3_d4ab_4e61_8eb0_114fed6f9991
is: P19801
type: Species
is encoded by: hsa:26
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ABP1

http://identifiers.org/biomodels.db/MODEL1310110030#_7746f124_628b_4e1c_a5f8_abdc67e072bf
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:80025
is: Q6P1K9
name: PANK2
boundary condition: true
has only substance units: false

metaR PROSTGE2t
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaM hs deg2 l
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: heparan sulfate, degradation product 2
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
initial concentration: 1.0
is: HMDB06254
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5acc8f8a_dead_48d5_9eb0_929af1316f4b
is: SBO:0000252
name: ALAS1
is encoded by: hsa:211
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P13196

http://identifiers.org/biomodels.db/MODEL1310110030#_a110eb89_8ec5_4e26_a319_ef67ad986067
is: Q02218
boundary condition: true
name: OGDH
type: Species
constant: false
is encoded by: hsa:4967
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM 2mp2coa m
boundary condition: false
is: HMDB01011
initial amount: NaN
is: CHEBI:27754
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
name: 2-Methylprop-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110030#_aaa8a74c_9211_43bd_a967_ba4761590e37
initial amount: NaN
is encoded by: hsa:518
has part: P48201
constant: false
boundary condition: true
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species

metaM ocdcea r
boundary condition: false
is: SBO:0000247
is: HMDB00207
initial concentration: 1.0
is: CHEBI:0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
has only substance units: false
initial amount: NaN
name: octadecenoate (n-C18:1)
is: C00712

metaR RE0690E
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reversible: false
kinetic law: MODEL1310110030#
name: RE0690
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_75c29e01_b79f_4bda_afe7_e3871d0eea76
name: CROT
is encoded by: hsa:54677
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: E7EQF2
type: Species

metaR RE3006M
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3006

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_78981932_13eb_4755_8e6e_3cf4f17e547b
has only substance units: false
is encoded by: hsa:65010
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: SLC26A6
initial amount: NaN
initial concentration: NaN
is: Q548A7

metaR NACHEX11ly
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reversible: false

metaR r2338
is: SBO:0000185
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000

metaR HSD3A2r
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
fast: false
modifier: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225

metaM dmnoncrn x
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06202
initial amount: NaN
boundary condition: false

metaR HEX1
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: hexokinase (D-glucose:ATP)
product: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110030#
is described by: ECO:0000134
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction

metaM dctp c
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial concentration: 1.0
type: Species
is: CHEBI:16311
has only substance units: false
is: SBO:0000247
constant: false
is: C00458
initial amount: NaN
boundary condition: false

metaM lnlccoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
is: HMDB01064

metaM acac c
has only substance units: false
is: SBO:0000247
name: acetoacetate
is: CHEBI:13705
initial concentration: 1.0
is: HMDB00060
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_55be5d97_5bd3_4177_9a5d_0d14b340de2f
initial amount: NaN
constant: false
name: CMPK1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51727
has only substance units: false
type: Species
is: B2R6S5
boundary condition: true

metaM HC00718 c
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
type: Species

metaM em2emgacpail hs r
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
has only substance units: false
initial amount: NaN
is: HMDB03125
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
is: CHEBI:16240
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_bc9e9ae2_a4fb_4615_8848_87da7bdcc9b2
has part: D3DNH0
is: SBO:0000297
type: Species
has only substance units: false
name: GYG1:GYS2
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:2992

http://identifiers.org/biomodels.db/MODEL1310110030#_969b9eb4_8ed0_4e22_a5d8_6ec467904422
is: P48067
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: SLC6A9
initial concentration: NaN
is encoded by: hsa:6536
has only substance units: false
initial amount: NaN

metaM 2mcit e
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00379
has only substance units: false
is: CHEBI:15598
constant: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
name: 2-methylcitrate(3-)

metaM ppcoa m
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
constant: false
name: Propanoyl-CoA
is: C00100
has only substance units: false
is: SBO:0000247
is: CHEBI:57392
initial concentration: 1.0

metaM arachd l
initial concentration: 1.0
name: arachidonate
constant: false
has only substance units: false
is: HMDB01043
boundary condition: false
initial amount: NaN
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
type: Species

metaM h c
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
has only substance units: false
type: Species
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: C00080

metaR HEX4
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000304
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
type: Reaction
reversible: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110030#
name: hexokinase (D-mannose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176

metaR r1418
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110030#
reactant: MODEL1310110030#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176
fast: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_edb38e6b_b103_4363_9547_6e8a7dabbaf5
boundary condition: true
is: P20594
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4882
name: NPR2

metaR RE2675C
notes: GENE_ASSOCIATION: (8560.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10722759,PMID:10880336,PMID:11937514,PMID:8449895 NOTES:
name: RE2675
kinetic law: MODEL1310110030#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
modifier: MODEL1310110030#

metaM crvnc e
notes: FORMULA: C22H31O2 CHARGE: -1
type: Species
constant: false
initial amount: NaN
is: CHEBI:36005
initial concentration: 1.0
is: HMDB02183
has only substance units: false
boundary condition: false
is: SBO:0000247
name: cervonic acid, C22:6 n-3

metaM retinal cis 13 r
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB06220
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
name: 13-cis-retinal
is: CHEBI:45487

http://identifiers.org/biomodels.db/MODEL1310110030#_3812f6a5_eea1_4f7b_b19c_a9a0ae7f6353
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:8402
initial concentration: NaN
is: F5GY65
boundary condition: true
name: SLC25A11
type: Species

metaR G16MT L
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
is: SBO:0000176
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR r2333
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR OAGT3tg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: oagt3 hs intracellular transport
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#
type: Reaction

metaM bamppald c
is: http://identifiers.org/pubchem.compound/7975
is: C05665
type: Species
has only substance units: false
is: HMDB01106
boundary condition: false
is: SBO:0000247
name: beta-Aminopropion aldehyde
initial concentration: 1.0
constant: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
initial amount: NaN

metaM lnlnca c
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
name: alpha-linolenate
is: HMDB01388
constant: false

metaR GLYtp
is: SBO:0000185
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
reversible: true
fast: false
name: glycine passive transport to peroxisome
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_4f6ab012_900c_41b5_9472_f7c7edd26ac6
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4723
is: E5KNH5
has only substance units: false
name: NDUFV1

metaM ksi pre14 g
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 14
has only substance units: false
constant: false
is: CHEBI:28067

metaM arachd r
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01043
has only substance units: false
name: arachidonate
initial concentration: 1.0
is: CHEBI:32395
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

metaR TRPO2
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
is version of: http://identifiers.org/ec-code/1.13.11.11
reversible: false
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110030#

metaR MALTt1r
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110030#
name: maltose transport (uniport)
reactant: MODEL1310110030#
is described by: ECO:0000269

metaM clpn hs c
is: SBO:0000247
is: CHEBI:21338
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: clpn_hs[c]
has only substance units: false
is: HMDB02704
notes: FORMULA: CHARGE: 0
boundary condition: false

metaR PVD3
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Previtamin D3 formation
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
fast: false
is: SBO:0000176
type: Reaction
reversible: true

metaM 13 cis retn r
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
initial amount: NaN
constant: false
has only substance units: false
name: 13-cis-retinoate
is: SBO:0000247
is: HMDB06219
type: Species
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952

http://identifiers.org/biomodels.db/MODEL1310110030#_91aa6ea7_d90f_488c_9184_09ccca2cf269
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: SLC23A2
is encoded by: hsa:9962
initial concentration: NaN

metaR r2334
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
fast: false
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_aa11932f_1301_42c7_9fdd_a52003af6827
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC5A10
is encoded by: hsa:125206
boundary condition: true
is: A0PJK1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_68c9f4a1_dcfc_4c43_a61b_f4cb39654a01
constant: false
boundary condition: true
is encoded by: hsa:4720
is: SBO:0000252
type: Species
is: B7Z792
initial amount: NaN
name: NDUFS2
has only substance units: false
initial concentration: NaN

metaR CYTK2n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is: SBO:0000176
reversible: true
name: cytidylate kinase (dCMP),nuclear

metaM thr L c
is: HMDB00167
type: Species
has only substance units: false
name: L-threonine
constant: false
initial concentration: 1.0
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_c10feb8d_da9a_41e2_be34_a7dae4a0aed7
initial amount: NaN
is: SBO:0000252
is: P04035
name: HMGCR
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3156

metaR RE2304E
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
name: RE2304
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (7177.1) or (64499.1) or (23430.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.59 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.4.21.59

metaR DCK1n
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110030#
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (ATP)
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#

metaR r2335
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_123c56e6_9f34_4a1d_893f_0e5a04b5e31a
constant: false
boundary condition: true
type: Species
name: CMPK1
is: SBO:0000252
is encoded by: hsa:51727
initial concentration: NaN
initial amount: NaN
is: B2R6S5
has only substance units: false

metaM mev R c
is: HMDB00227
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
is: SBO:0000247
name: (R)-mevalonate
is: CHEBI:36464
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_61369ffb_420c_4fe9_87d6_483ca802400c
is: SBO:0000252
initial amount: NaN
is: Q9H6Y6
is encoded by: hsa:4645
constant: false
name: MYO5B
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR OAGT3te
type: Reaction
fast: false
is: SBO:0000185
name: oagt3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
reversible: true

metaM ocdcea l
boundary condition: false
name: oleate
is: HMDB00207
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
initial amount: NaN
is: CHEBI:30823
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r2139
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM lnlnca e
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial concentration: 1.0
name: alpha-linolenate
type: Species
is: SBO:0000247
is: HMDB01388
has only substance units: false
is: CHEBI:32387
boundary condition: false

metaR GLGNS1
name: glycogen synthase (ggn -> glygn1)
is: SBO:0000176
reversible: false
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (8908.1) and (2997.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2998.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 2.4.1.11 Confidence Level: 2 AUTHORS: PMID:15238248 NOTES:NCD
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.11
product: MODEL1310110030#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.186
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_a538bff2_350b_472c_8205_d0bd256215d3
type: Species
is encoded by: hsa:4718
initial amount: NaN
initial concentration: NaN
constant: false
name: NDUFC2
is: Q549M5
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM pre prot r
boundary condition: false
is: CHEBI:16240
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB03125
notes: FORMULA: XY CHARGE: 0
type: Species
is: SBO:0000247
name: glycophosphatidylinositol (GPI)-anchored protein precursor

http://identifiers.org/biomodels.db/MODEL1310110030#_b365b3cf_1c0f_42cc_b90a_707ac16002f2
has only substance units: false
boundary condition: true
name: COX3
is: SBO:0000252
is: P00414
is encoded by: hsa:4514
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM CE4790 m
initial concentration: 1.0
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: CHEBI:15748
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00127

metaM 5pmev x
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01343
type: Species
name: (R)-5-phosphonatomevalonate(3-)
is: CHEBI:58146
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
boundary condition: false
constant: false
has only substance units: false

metaR MACOXO
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
product: MODEL1310110030#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110030#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_bb82e2d2_9fe9_48c3_b59c_5c8ee0ce7def
has only substance units: false
name: NDUFS3
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O75489
type: Species
is encoded by: hsa:4722
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7610b45d_fbad_4714_9786_f9b2537d4168
boundary condition: true
is encoded by: hsa:9194
name: SLC16A7
is: SBO:0000252
constant: false
is: Q8NEM3
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaM dolp U r
initial amount: NaN
has only substance units: false
is: CHEBI:57683
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9f004df0_51cf_414a_874c_ff16dc5b603d
initial amount: NaN
is: D6RDW3
name: GUCY1A3
has only substance units: false
boundary condition: true
is encoded by: hsa:2982
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM cspg a l
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005
initial amount: NaN
constant: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB02183

metaM thr L e
boundary condition: false
type: Species
constant: false
has only substance units: false
name: L-threonine
is: CHEBI:16857
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
is: HMDB00167

metaR r1743
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110030#

metaR GLYtm
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110030#
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

metaR HACD1m
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reversible: true
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
modifier: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR CHAT
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110030#
modifier: MODEL1310110030#
name: Choline O-acetyltransferase
type: Reaction

metaR RTOTAL2FATPc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR ADK1
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
name: adenylate kinase
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM crn x
initial concentration: 1.0
is: C00318
is: CHEBI:16347
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB00062
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247

metaM HC02213 c
is: SBO:0000247
boundary condition: false
is: CHEBI:28031
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
initial amount: NaN
name: prostaglandin-e3

http://identifiers.org/biomodels.db/MODEL1310110030#_4d67b8f3_b24b_49fe_88ef_f31e09523a38
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:11112
name: HIBADH
type: Species
is: P31937
constant: false
initial amount: NaN

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: sph1p transport
fast: false
type: Reaction
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a0bc8f81_3ea2_4ce7_9d4c_22872c282d26
is: Q8NFL0
name: B3GNT7
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:93010
constant: false
initial amount: NaN

metaR BAAT4x
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
product: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110030#_d7ab6087_ee4b_4f24_950a_24cb68055c7c
name: ISYNA1
has only substance units: false
initial concentration: NaN
is: B3KRT1
is encoded by: hsa:51477
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR S4TASE5ly
is described by: ECO:0000000
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110030#
product: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is: SBO:0000176

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM HC02204 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27624
initial concentration: 1.0
has only substance units: false

metaR ASNtN1
reactant: MODEL1310110030#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Asparagine transport (Na, H coupled)
type: Reaction
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_d2d34820_3984_4aff_bee2_b821f81a367d
is: Q7GXZ1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ND6
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4541

http://identifiers.org/biomodels.db/MODEL1310110030#_fcbdb8db_81ba_4e11_a340_f65d530db3b7
type: Species
has only substance units: false
name: PDE9A
constant: false
boundary condition: true
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
product: MODEL1310110030#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
fast: false
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0fd7f3ef_aa1e_40f1_ba1e_cba231d37dda
is encoded by: hsa:9162
boundary condition: true
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: O75912
initial amount: NaN
name: DGKI

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR DURIK1
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110030#
is described by: ECO:0000254
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
name: deoxyuridine kinase (ATP:Deoxyuridine)
reversible: false

metaR r2341
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaM glyald c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01051
has only substance units: false
is: C00577
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
name: D-Glyceraldehyde
type: Species
is: CHEBI:17378

metaR ARGLYSex
modifier: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
name: Arginine/Lysine exchanger (Arg in)
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
product: MODEL1310110030#
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_049bfd1a_0d0e_4b47_ae20_46c984ceae49
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:205
initial concentration: NaN
is: P27144
name: AK4
initial amount: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_db40b462_8416_47f5_9575_ef7d21fd5b3c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84532
type: Species
has only substance units: false
is: Q9NUB1
initial concentration: NaN
name: ACSS1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_df0c08fa_f74d_44f2_bffc_2854c0826f93
initial amount: NaN
type: Species
name: _HG2846_HT2983_1_c
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:HG2846-HT2983
has only substance units: false
is: SBO:0000252

metaR PMEVKx
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.2
reversible: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
kinetic law: MODEL1310110030#
name: phosphomevalonate kinase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110030#_5e1380b9_f31e_4160_a749_d6f5e368fd03
type: Species
constant: false
name: GALNT9
boundary condition: true
is: SBO:0000252
is: Q9HCQ5
is encoded by: hsa:50614
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM h l
name: proton
boundary condition: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: C00080
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "

http://identifiers.org/biomodels.db/MODEL1310110030#_d9be2d3e_8b8a_4092_9162_b0514c1c6103
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: Q86T14
is encoded by: hsa:51292
name: GMPR2
boundary condition: true

metaR PPNCL3
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110030#
name: phosphopantothenate-cysteine ligase
reactant: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_d88255e4_a10e_4629_b7a6_c3a45102dc07
name: SLC9A1
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:6548
type: Species
is: P19634
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_02907b8a_22ac_4dd2_88f2_94cc8ce23226
type: Species
is: SBO:0000252
is: P54819
constant: false
initial amount: NaN
name: AK2
is encoded by: hsa:204
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_f2571461_7dd8_498d_b076_c0a8443ac0a5
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9UKK9
type: Species
constant: false
initial concentration: NaN
name: NUDT5
is encoded by: hsa:11164

metaR r2344
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_475dd641_1b7a_4023_806c_387f7971d685
is encoded by: hsa:400410
has only substance units: false
is: Q9HBF5
constant: false
name: ST20
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_6d6b14a9_3f49_4abb_a504_f4e6a82a6108
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALPL
has only substance units: false
type: Species
is encoded by: hsa:249
constant: false
initial amount: NaN
is: B7Z4Y6

metaR NACHEX23ly
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM lpchol hs e
boundary condition: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
name: lysophosphatidylcholine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM HC02207 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:27555
name: prostaglandin-c2
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_821f331c_c932_4a05_b55f_dc2b03ea5fb4
is encoded by: hsa:4700
type: Species
initial amount: NaN
is: SBO:0000252
is: P56556
name: NDUFA6
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_9c4b783a_c0e3_451b_8e64_22e4eca38612
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30833
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is: Q8TCD5
name: NT5C

http://identifiers.org/biomodels.db/MODEL1310110030#_8c97ba99_7fa3_4bc8_98e7_7035acde5b52
is: SBO:0000252
initial concentration: NaN
is: P17752
boundary condition: true
has only substance units: false
name: TPH1
constant: false
type: Species
is encoded by: hsa:7166
initial amount: NaN

metaM ksi deg24 l
boundary condition: false
is: CHEBI:12936
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
name: keratan sulfate I, degradation product 24
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110030#_34a1d384_c378_4cf1_81c6_bf3d2178edd6
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:622
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: BDH1

metaR It
reactant: MODEL1310110030#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
kinetic law: MODEL1310110030#
type: Reaction
name: Iodide uniport
is described by: ECO:0000269
modifier: MODEL1310110030#
product: MODEL1310110030#

metaM fum m
is: CHEBI:29806
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
name: Fumarate
initial amount: NaN
is: HMDB00134
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR CYSGLYexR
is: SBO:0000185
modifier: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_0a26425e_70b8_4c43_857d_4e2d03a08854
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11001
constant: false
type: Species
name: SLC27A2
is: O14975
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_5a93a822_83df_4089_881d_5cb52bd1d886
is: B4DWD7
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:79901
constant: false
initial amount: NaN
has only substance units: false
name: CYBRD1
is: SBO:0000252

metaM crn r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: (R)-carnitine
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16347
has only substance units: false
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110030#_7a72ac86_7127_41c2_b8ab_a4ea8f57e8d4
name: LDHD
is encoded by: hsa:197257
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR r0463
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
kinetic law: MODEL1310110030#

metaM mgacpail hs r
initial amount: NaN
is: C00249
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: CHEBI:7896
is: HMDB00220
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_8f086548_24a9_4d0d_a77e_af827272ea1d
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:498
is: SBO:0000252
name: ATP5A1
is: A8K092
has only substance units: false

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17759
is: HMDB00032
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1f525fae_6517_429a_bcb6_fb5f150b6587
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9H936
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:79751
name: SLC25A22

metaM lpchol hs c
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial concentration: 1.0
name: lysophosphatidylcholine
is: SBO:0000247
is: CHEBI:60479
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaM HC01397 x
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27402
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247

metaM h e
initial concentration: 1.0
name: proton
is: C00080
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
is: SBO:0000247
is: CHEBI:24636
boundary condition: false
type: Species

metaM octd11ecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB12969
has only substance units: false
initial concentration: 1.0
name: 11-octadecenoylcoa

metaR r0618
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110030#

metaR H2Otly
name: H2O transport, lysosomal
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_6ee7e757_9c1f_4eee_b5ef_32568d0ec8b2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:26
is: P19801
type: Species
has only substance units: false
name: ABP1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_57d28c14_593c_4d80_92eb_29af8722d1a4
name: SLC2A13
initial concentration: NaN
constant: false
is: Q96QE2
is encoded by: hsa:114134
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM gpi sig r
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
constant: false
notes: FORMULA: Y CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58190
is: HMDB00224
type: Species
has only substance units: false
boundary condition: false

metaM acac e
initial amount: NaN
constant: false
type: Species
is: HMDB00060
has only substance units: false
is: SBO:0000247
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
boundary condition: false
name: acetoacetate

metaR DOLASNT Ler
modifier: MODEL1310110030#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
reversible: false
product: MODEL1310110030#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.119
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR DGK1
reactant: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110030#
name: deoxyguanylate kinase (dGMP:ATP)
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269
type: Reaction

metaR r0504
kinetic law: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
fast: false
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM h g
is: CHEBI:24636
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
name: proton
is: SBO:0000247
initial amount: NaN

metaR RE3565C
name: RE3565
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR GLCAASE9ly
kinetic law: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction

metaR RE0944E
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
name: RE0944
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_2fd72a9e_4253_4672_a724_19f1f8478aa8
constant: false
is: SBO:0000252
is: Q86SR1
initial amount: NaN
name: GALNT10
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:55568
initial concentration: NaN

metaR r0616
modifier: MODEL1310110030#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110030#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
type: Reaction
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_c56e58e6_ac84_4686_b1aa_2efb91abddc3
has only substance units: false
name: ALDH3B2
is encoded by: hsa:222
is: P48448
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_7d2abc36_1828_4ee1_b477_80f7201c6daf
boundary condition: true
is encoded by: hsa:4720
type: Species
is: B7Z792
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NDUFS2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_9aba3e92_417a_41db_ba44_a9e466c5774d
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: AGPAT1
is: Q99943
is encoded by: hsa:10554
has only substance units: false
constant: false

metaM ksii core4 pre4 g
constant: false
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0
is: C00130
is: HMDB00175
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d2d1fc79_d255_434c_9123_04081a2f020a
type: Species
has only substance units: false
initial amount: NaN
is: P53004
is encoded by: hsa:644
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: BLVRA

metaR r0464
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000176
reversible: true
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

metaR RIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
name: ribose transport via diffusion
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true

metaR INSTt2r
name: inositol transport in via proton symport
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reversible: true
is described by: ECO:0000269
product: MODEL1310110030#
fast: false

metaR r0354
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110030#
fast: false
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaM h r
type: Species
is: C00080
boundary condition: false
initial concentration: 1.0
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:32984

http://identifiers.org/biomodels.db/MODEL1310110030#_df14593c_1ca2_4dea_aeb5_8fafac4aa91f
constant: false
is encoded by: hsa:215
initial amount: NaN
name: ABCD1
is: SBO:0000252
is: P33897
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM ksi deg21 l
initial concentration: 1.0
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 21
boundary condition: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
type: Species
is: HMDB00143
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM leuktrD4 e
is: SBO:0000247
is: HMDB03080
is: CHEBI:28666
name: Leukotriene D4
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaM dtdp n
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01274
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

http://identifiers.org/biomodels.db/MODEL1310110030#_b05023d7_e6a4_42ff_9dda_54eb3fe6e4e0
has only substance units: false
initial amount: NaN
is: Q96IJ6
is encoded by: hsa:29926
initial concentration: NaN
constant: false
is: SBO:0000252
name: GMPPA
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_2aed4eb1_08cd_4f19_9fb6_af0a80d2c3ce
is: O15244
initial amount: NaN
initial concentration: NaN
name: SLC22A2
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6582
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_a214de63_7bff_467d_82b3_ecd9699f312c
initial amount: NaN
name: PGM3
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: B4DX94
type: Species
is: SBO:0000252
is encoded by: hsa:5238

metaR r2142
is described by: ECO:0000000
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
reversible: true
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110030#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction

metaM btn c
boundary condition: false
is: SBO:0000247
is: CHEBI:3420
constant: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
initial amount: NaN
name: Biotin
is: HMDB00030
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5d761bb6_cf27_4de2_b082_2822c14b4cc3
constant: false
boundary condition: true
is: Q7Z7M8
name: B3GNT8
has only substance units: false
is encoded by: hsa:374907
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR r0614
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36

metaM dtdp m
initial concentration: 1.0
constant: false
is: SBO:0000247
name: dTDP
is: HMDB01274
type: Species
is: C00363
is: CHEBI:58369
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_60b4a410_0ed9_453e_aae7_31ea4ede3905
constant: false
is: SBO:0000252
initial concentration: NaN
is: P56381
is encoded by: hsa:514
type: Species
name: ATP5E
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_28c5fc9b_712f_45b1_9cdb_96efd55b2c37
type: Species
name: PTGS2
is encoded by: hsa:5743
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P35354

metaM 3sala c
initial amount: NaN
type: Species
name: 3-Sulfino-L-alanine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
constant: false
has only substance units: false
is: C00606

http://identifiers.org/biomodels.db/MODEL1310110030#_bbedef93_1951_4050_88d6_b6d1891f07d2
constant: false
has only substance units: false
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR r2141
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
modifier: MODEL1310110030#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110030#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR DNDPt37m
modifier: MODEL1310110030#
name: dUTP transport via dTDP antiport
type: Reaction
reactant: MODEL1310110030#
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110030#
is described by: ECO:0000269

metaM 7dhchsterol r
is: CHEBI:17759
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_e7e80ce2_5517_4505_bfd5_185bd2f5410e
is: Q9NRA2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC17A5
boundary condition: true
is encoded by: hsa:26503
type: Species
constant: false
initial amount: NaN

metaM maltttr e
name: Maltotetraose
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C02052
is: http://identifiers.org/pubchem.compound/5141
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01296

metaM ach n
initial concentration: 1.0
has only substance units: false
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: acetylcholine
is: SBO:0000247
is: CHEBI:15355

metaR r2497
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3

metaM lnlnca r
type: Species
name: alpha-linolenate
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:32387
is: SBO:0000247
has only substance units: false

metaR S2TASE3ly
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
name: iduronate-2-sulfatase, lysosomal
modifier: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_f0aae012_bc19_4be6_ae02_eda55a502516
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8395
boundary condition: true
is: O14986
constant: false
is: SBO:0000252
name: PIP5K1B

http://identifiers.org/biomodels.db/MODEL1310110030#_ce8ee83d_b9f1_4113_9151_17a5cc306130
constant: false
is: SBO:0000252
is: Q16647
initial amount: NaN
name: PTGIS
has only substance units: false
type: Species
is encoded by: hsa:5740
initial concentration: NaN
boundary condition: true

metaR r2140
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
modifier: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_41d09d1d_94f8_4000_947e_5170340c15d1
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC4A1
is encoded by: hsa:6521
is: P02730
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r0355
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110030#
fast: false
type: Reaction
reactant: MODEL1310110030#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
product: MODEL1310110030#

metaM crn m
is: HMDB00062
is: CHEBI:16347
name: L-Carnitine
is: C00318
type: Species
has only substance units: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM mev R x
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
is: SBO:0000247
is: HMDB00227
boundary condition: false
is: CHEBI:36464
name: (R)-mevalonate
has only substance units: false
type: Species

metaM glyald m
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17378
is: HMDB01051
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
name: D-glyceraldehyde

http://identifiers.org/biomodels.db/MODEL1310110030#_d9f27087_80ab_43b2_a8f5_215a38771bcd
has only substance units: false
initial concentration: NaN
name: GUCY2F
type: Species
is encoded by: hsa:2986
is: P51841
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
reactant: MODEL1310110030#
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110030#
reversible: true
product: MODEL1310110030#

metaR DUTPDPn
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23
reversible: false
modifier: MODEL1310110030#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110030#

metaR CSNATer
is described by: ECO:0000254
reversible: true
kinetic law: MODEL1310110030#
name: carnitine O-acetyltransferase, endolasmic reticulum
fast: false
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_794a6a65_2b7e_47b7_b280_2bf6aaf9258c
initial amount: NaN
constant: false
has only substance units: false
is: Q9P0J0
initial concentration: NaN
is: SBO:0000252
name: NDUFA13
boundary condition: true
type: Species
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110030#_a47b5137_ea98_4bcf_8820_d40323ed222b
is: SBO:0000252
type: Species
constant: false
name: SYNJ1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8867
is: O43426
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_4184d86c_49b1_429c_9830_173a42b508fe
is encoded by: hsa:28231
is: Q96BD0
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: SLCO4A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_135c1cf2_803a_4fab_adb9_c03b985cbc6b
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI091231
initial amount: NaN
name: _AI091231_1_c
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cfae6f17_91c1_435e_b6b4_dac527347b34
is encoded by: hsa:10331
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: B3GNT3
type: Species
constant: false
is: SBO:0000252
is: Q9Y2A9
has only substance units: false

metaM h n
initial amount: NaN
boundary condition: false
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
constant: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
has only substance units: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM hs deg20 l
type: Species
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16126

metaR NDPK4n
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaR G14T21g
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM ppcoa x
is: HMDB01275
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Propanoyl-CoA
has only substance units: false
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110030#_cb6b56a2_e06b_4698_b875_3de98bbc899c
constant: false
type: Species
name: GAD1
initial amount: NaN
is encoded by: hsa:2571
boundary condition: true
is: Q8IVA8
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR COUCOAFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
type: Reaction
name: p-coumaroyl-CoA formation
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false

metaM eicostetcoa c
is: C16164
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: eicosatetranoyl coenzyme A
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1

metaR UGLCNACtg
reactant: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
reversible: true
name: UDP-GlcNAc Golgi transport via CMP antiport
is: SBO:0000185
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110030#

metaM h m
is: C00080
boundary condition: false
constant: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
is: CHEBI:27555
initial concentration: 1.0
name: prostaglandin-c2
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR PYNP2r
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#

metaR r1301
is: SBO:0000185
product: MODEL1310110030#
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
fast: false
name: Vesicular transport
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_534a2f26_7af4_44b9_870b_f5c6b2b53fbe
is: O00754
constant: false
boundary condition: true
has only substance units: false
name: MAN2B1
type: Species
is encoded by: hsa:4125
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM leuktrD4 c
initial amount: NaN
name: Leukotriene D4
is: HMDB03080
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28666
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaM acac m
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
constant: false
is: CHEBI:13705
is: HMDB00060
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM leuktrA4 c
is: CHEBI:57463
name: leukotriene A4(1-)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01337
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false

metaM hs deg5 l
is: SBO:0000247
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
type: Species
has only substance units: false
is: HMDB00158
is: CHEBI:17895
initial amount: NaN
initial concentration: 1.0
name: heparan sulfate, degradation product 5
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_36e7b1a9_6c2d_43cf_89c6_7c04868161e3
boundary condition: true
is encoded by: hsa:7264
is: Q13630
initial concentration: NaN
has only substance units: false
type: Species
name: TSTA3
constant: false
initial amount: NaN
is: SBO:0000252

metaM lnlccoa m
boundary condition: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial amount: NaN
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaR r1302
name: Vesicular transport
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_b7b59435_c6b4_4f4a_b35c_e0546add214b
is encoded by: hsa:441024
has only substance units: false
is: Q9H903
boundary condition: true
initial amount: NaN
constant: false
name: MTHFD2L
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_dc45143a_7077_4210_9a2c_3f2cd5e08ee5
name: SLC27A3
constant: false
is encoded by: hsa:11000
initial amount: NaN
is: Q5K4L6
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaM dmnoncrn m
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB06202
is: SBO:0000247
name: 4,8 dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
initial concentration: 1.0
initial amount: NaN

metaR ICDHy
product: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
name: isocitrate dehydrogenase (NADP)
reversible: false
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
fast: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM glu5sa m
initial amount: NaN
name: L-Glutamate 5-semialdehyde
has only substance units: false
is: HMDB02104
is: CHEBI:17232
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: C01165
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247

metaR r0779
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM dolp U c
has only substance units: false
is: CHEBI:57683
boundary condition: false
type: Species
name: dolichyl phosphate(2-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247

metaM 6thf e
boundary condition: false
name: hexaglutamyl folate (THF)
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/169691

http://identifiers.org/biomodels.db/MODEL1310110030#_b98f6ccc_5fde_448b_a95b_7064eb3bcf7b
has only substance units: false
is: P57054
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:51227
is: SBO:0000252
initial amount: NaN
name: PIGP

metaM oxa x
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
is: CHEBI:30623
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02329
constant: false

metaR r0787
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110030#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
fast: false

metaR DGSNtm
name: deoyguanosine transport in mitochondria
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110030#

metaR RTOTAL3FATPc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_8177d137_13bc_4663_a87d_88eb2ebd3fc2
is encoded by: hsa:220
constant: false
has only substance units: false
name: ALDH1A3
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P47895
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_ac8d62c6_99ad_4977_8a85_ea21d8d918c6
is: Q9H2X9
has only substance units: false
type: Species
boundary condition: true
name: SLC12A5
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57468
initial concentration: NaN

metaM C02528 c
type: Species
is: SBO:0000247
name: chenodeoxycholate
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00518
is: CHEBI:36234
initial amount: NaN

metaM m3mpdol L c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1480H2428N20O370P20 CHARGE: -20
constant: false
type: Species
is: SBO:0000247
is: CHEBI:37632
initial amount: NaN
has only substance units: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human liver homolog

metaM ser L c
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
is: HMDB00187
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17115
is: SBO:0000247
name: L-serine
type: Species

metaR APRGSTRNte
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is: SBO:0000185
name: hydroxyprogesterone transport

metaM T4hcinnm m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
type: Species
is: HMDB02035
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:12876
name: trans-4-coumarate
boundary condition: false

metaR GALSGLT1le
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_78131713_7e1a_4e63_a97a_f8ba990a80b1
has only substance units: false
constant: false
is encoded by: hsa:6563
type: Species
initial amount: NaN
name: SLC14A1
initial concentration: NaN
is: G0W2N5
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_a1d25dbb_9574_49d7_a251_76d60de3d950
boundary condition: true
has only substance units: false
type: Species
is: P36542
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: ATP5C1
is encoded by: hsa:509

metaR TAGt
fast: false
name: triacylglycerol transport
is: SBO:0000185
reversible: true
product: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR LEUKTRF4t
reversible: true
product: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: leukotriene F4 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000

metaR r0788
reactant: MODEL1310110030#
fast: false
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reactant: MODEL1310110030#
is described by: ECO:0000304
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
type: Reaction
name: ceramide transport protein
reversible: true

metaM crn c
is: HMDB00062
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:16347
initial amount: NaN
has only substance units: false
is: C00318

metaM val L c
is: CHEBI:16414
boundary condition: false
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00883
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_2443b083_a9e3_49a7_b17d_99aa002c1f2d
is: SBO:0000252
constant: false
has only substance units: false
name: _NM_013421_1_m
type: Species
is encoded by: hsa:NM 013421
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_bd38c2b0_df71_48ea_9bd6_ca28b7d0a5ba
name: GCDH
is encoded by: hsa:2639
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR CYTK3n
type: Reaction
is: SBO:0000176
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
reactant: MODEL1310110030#

metaR DOLPMT4 Uer
reversible: false
kinetic law: MODEL1310110030#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110030#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110030#

metaM ksi deg19 l
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
boundary condition: false
is: HMDB00812
type: Species
name: keratan sulfate I, degradation product 19

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reactant: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
fast: false
name: L-carnitine reversible transport
product: MODEL1310110030#

metaR r0022
type: Reaction
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reversible: true

metaM biocyt e
is: C05552
boundary condition: false
is: SBO:0000247
type: Species
name: Biocytin
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_13427da2_ca0f_476a_bb8d_dbf5ec94b9c7
name: GPI
boundary condition: true
is encoded by: hsa:2821
initial amount: NaN
is: P06744
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_2423415c_8793_4439_ae3a_37a992aaae0a
is encoded by: hsa:22305
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: _22305_2_c
boundary condition: true
initial concentration: NaN

metaM ksii core2 pre8 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
boundary condition: false
type: Species
is: CHEBI:58053
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
initial amount: NaN
is: C00130
is: SBO:0000247
is: HMDB00175

metaM 5dhf e
has only substance units: false
is: HMDB06487
constant: false
initial amount: NaN
name: pentaglutamyl folate (DHF)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_960c9038_2132_4fa4_9c0a_4f33596529e9
has only substance units: false
name: GYS2
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2998
is: P54840
boundary condition: true

metaM crn e
name: L-Carnitine
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
initial amount: NaN
boundary condition: false
is: C00318
is: HMDB00062

metaM pmtcrn r
name: L-palmitoylcarnitine
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00222
constant: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR S2TASE2ly
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.6.13

metaR FAOXC11C9m
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_737d9c60_3682_463a_9bf1_d362ea382bfd
is encoded by: hsa:411
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: ARSB
is: SBO:0000252
is: P15848
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_0396b390_7652_457a_baca_f7f60fc2ef21
type: Species
is: SBO:0000252
initial amount: NaN
is: E5KS60
name: SUCLA2
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8803

metaR r0783
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reversible: true
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#

metaR BMTer U
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
name: B mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: false
is: SBO:0000176

metaR ALADGLNexR
reversible: true
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110030#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110030#_7f1adbb1_50bd_4555_b892_df6cf5a771f2
type: Species
is encoded by: hsa:5277
boundary condition: true
constant: false
initial amount: NaN
is: B3KUV7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PIGA

metaM core4 g
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Core 4
is: CHEBI:16478
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C24H40N3O15X CHARGE: 0

metaM cdpchol c
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01413
is: SBO:0000247
name: CDPcholine
is: CHEBI:16436
type: Species
boundary condition: false

metaR GLB1
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
name: Beta-galactosidase
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
kinetic law: MODEL1310110030#

metaR r0784
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110030#

metaM pmtcrn x
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
constant: false
name: L-palmitoylcarnitine
type: Species
initial concentration: 1.0
is: CHEBI:17490

metaR S23T4g
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase
reversible: false
reactant: MODEL1310110030#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110030#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#

metaR Htr
reactant: MODEL1310110030#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6bb8bb31_96f3_4177_bd06_ac46c239beb8
constant: false
has only substance units: false
name: FLAD1
initial amount: NaN
is: Q8NFF5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80308
boundary condition: true
type: Species

metaM HC00319 c
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_ae72d872_835e_4080_9788_064921047a5c
is: SBO:0000252
is encoded by: hsa:5152
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PDE9A

metaR NACHEX15ly
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110030#
reversible: false

metaR RE3005M
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE3005
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_ccbcdbf6_bb33_4936_997a_be3497143086
is: Q16881
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:7296
name: TXNRD1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_6b1d100c_f0ab_4dfb_abc9_e45107b2c206
is: O60909
boundary condition: true
is encoded by: hsa:8704
initial concentration: NaN
name: B4GALT2
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR RTOTAL2t
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110030#
name: RTOTAL2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110030#

metaR RE0567C
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0567
product: MODEL1310110030#
fast: false

metaM lpam m
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: lipoamide
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
is: CHEBI:17460
type: Species
initial amount: NaN
is: HMDB00962

metaR ARACHCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110030#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
reactant: MODEL1310110030#
name: carnitine transferase

metaR N4Tg
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110030#
product: MODEL1310110030#

metaR RE2649C
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110030#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110030#_16520a3a_42f7_426a_9104_0034a9dd8337
name: GMPPB
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29925
initial concentration: NaN
initial amount: NaN
is: Q9Y5P6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_1bffd99c_c25a_45c0_99f4_b65e05345d49
initial amount: NaN
name: PIGL
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: Q9Y2B2
is encoded by: hsa:9487

metaM glygn2 c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:17115
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
is: HMDB00187
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM itp n
initial amount: NaN
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: ITP(3-)
is: CHEBI:57614
type: Species
constant: false

metaM dmnoncrn c
initial concentration: 1.0
constant: false
is: HMDB06202
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine

metaM acac x
initial concentration: 1.0
is: HMDB00060
has only substance units: false
name: acetoacetate
is: CHEBI:13705
boundary condition: false
constant: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_2af1ea1b_e6d6_4d09_808d_ce47f7a934f9
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:178
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AGL
boundary condition: true

metaR 4MOPte
fast: false
type: Reaction
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 4-methyl-2-oxopentanoate
reversible: true
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185

metaR HS4ly
name: heparan-N-sulfatase, lysosomal
fast: false
product: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110030#
reversible: false
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
reactant: MODEL1310110030#

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM xol7ah3 m
is: HMDB12455
initial concentration: 1.0
type: Species
is: CHEBI:28540
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

metaR ARACHCPT1
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110030#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
fast: false
product: MODEL1310110030#

metaR PROSTGE1t
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_5794c845_52b1_4b95_adf7_9c92bba94518
is: SBO:0000252
is: B1AK53
boundary condition: true
has only substance units: false
name: ESPN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:83715
initial concentration: NaN

metaR NTD7
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110030#
name: 5'-nucleotidase (AMP)
fast: false
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000176

metaR r0027
product: MODEL1310110030#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.14.13.39

metaR D LACt2
is: SBO:0000185
product: MODEL1310110030#
name: D-lactate transport via proton symport
fast: false
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
name: NO transport (diffusion)
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is: SBO:0000185
reversible: true

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9adb0962_51fa_46bb_aab1_73af4daac891
is: Q9UF12
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: PRODH2
is encoded by: hsa:58510
type: Species
constant: false

metaR NACHEX18ly
type: Reaction
modifier: MODEL1310110030#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_eb37a3db_c572_4836_b19c_d82ef4c96ac6
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: HSD17B10
is: Q99714
is encoded by: hsa:3028
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_b4c2a174_f1fa_4354_a4b0_30ff1201580d
initial concentration: NaN
is: SBO:0000252
name: GMPS
boundary condition: true
is encoded by: hsa:8833
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: P49915

http://identifiers.org/biomodels.db/MODEL1310110030#_d7773959_42a9_4302_af23_1df210af8754
boundary condition: true
has only substance units: false
name: SLC4A3
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6508
initial amount: NaN
is: SBO:0000252
is: P48751

http://identifiers.org/biomodels.db/MODEL1310110030#_d132160a_68cf_4943_a8aa_8d251213737b
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
constant: false
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110030#_0d20c5e8_5830_45dd_a569_89988afc369a
has only substance units: false
name: ODC1
type: Species
is encoded by: hsa:4953
is: P11926
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_f8074509_2f96_4d83_b828_ac0109d31d34
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O94903
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11212
constant: false
name: PROSC
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_21557a01_e6d4_4f8e_a7ec_68f81da32698
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: _AI915649_1_c
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI915649

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110030#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110030#
reversible: true
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true

metaM q10h2 m
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
is: HMDB13111
name: Ubiquinol-10
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR r1599
product: MODEL1310110030#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110030#
name: deoxycytidine transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_cf68beeb_8a53_42f5_b1d0_3625bb746133
name: SLC35A2
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:7355
is: P78381
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_5217aef7_0382_4089_83b9_92a1b618aed2
type: Species
constant: false
is: SBO:0000252
name: _F23536_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:F23536
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_e821003b_13cf_4d62_bae2_c585731046a9
boundary condition: true
is: Q9H015
name: SLC22A4
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6583
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_6f5cb934_700f_4507_a4b0_4e3b8a8f42a8
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:38
is: P24752
name: ACAT1
boundary condition: true

metaR DHORD9
fast: false
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
modifier: MODEL1310110030#
reversible: false
product: MODEL1310110030#
is: SBO:0000185
name: dihydoorotic acid dehydrogenase (quinone10)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.5.2

http://identifiers.org/biomodels.db/MODEL1310110030#_d49b947e_9960_4561_8f54_39af2358cfdc
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q8TD20
boundary condition: true
is encoded by: hsa:154091
is: SBO:0000252
name: SLC2A12
initial amount: NaN

metaM peamn c
initial amount: NaN
is: CHEBI:225237
name: 2-phenylethanaminium
is: HMDB12275
constant: false
has only substance units: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110030#_79135ffc_0cb4_40fb_b7b8_c9b434231274
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:R14373
boundary condition: true
name: _R14373_1_x

metaM CE0849 m
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
constant: false
name: cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
is: C01936
initial amount: NaN

metaR DCK2n
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (UTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74

metaM dd2coa x
is: CHEBI:57330
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
has only substance units: false
constant: false
name: trans-Dodec-2-enoyl-CoA
initial amount: NaN
is: HMDB03712
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR MM6bg
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
is described by: ECO:0000000
product: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_89479408_71c0_4319_844b_ce83c70eac6c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P36969
boundary condition: true
name: GPX4
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110030#_338a894c_8282_4637_8413_58c11098f333
boundary condition: true
initial amount: NaN
is encoded by: hsa:7371
is: Q9BZX2
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: UCK2
type: Species

metaR BDMT L
fast: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.142

http://identifiers.org/biomodels.db/MODEL1310110030#_947afb0e_aad6_4042_a0a1_f87c0cee707f
constant: false
boundary condition: true
is encoded by: hsa:AA278423
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: _AA278423_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_59a3f99e_4c44_4533_a96d_db5bfaf6fffd
initial amount: NaN
name: _AA664770_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AA664770

http://identifiers.org/biomodels.db/MODEL1310110030#_a1cc0614_3e0e_4607_91c5_cc8c2ba64c98
name: MOGS
is encoded by: hsa:7841
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: F5H6D0
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR Htg
fast: false
type: Reaction
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_b88a3b9a_8acf_47e4_b5dd_f40de3f6834b
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:443
type: Species
name: ASPA
boundary condition: true
initial concentration: NaN
is: Q6FH48
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_674fc87f_aa73_4958_93de_e164d59d81c6
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: B7Z5G2
constant: false
name: GBA
type: Species
is encoded by: hsa:2629
initial amount: NaN

metaM 3tetd7ecoa m
is: CHEBI:57449
has only substance units: false
constant: false
initial amount: NaN
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

metaR PROSTGF2t
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110030#
name: prostaglandin uniport
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000269

metaR r1596
is: SBO:0000185
fast: false
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
kinetic law: MODEL1310110030#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_9804f020_34ac_4944_89d1_88acd3008ace
name: AGL
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:178

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_357d44cb_416f_436b_9a6a_2e0f8020b9d8
name: ACAT2
constant: false
boundary condition: true
type: Species
is encoded by: hsa:39
has only substance units: false
is: Q9BWD1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_478e0e12_7a20_440f_ba0b_951c9974e6d2
is: Q7GXZ8
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4513
name: COX2
is: SBO:0000252
constant: false
type: Species

metaR r0480
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000176

metaR ACCOAC
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r1595
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: true
product: MODEL1310110030#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_9e9810d8_4f0a_48bf_b171_94fd5fcb5b82
name: SUCLG2:SUCLG1
boundary condition: true
constant: false
initial amount: NaN
has part: P53597
type: Species
has part: Q96I99
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8801
is encoded by: hsa:8802
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_effd4be5_37cd_48ed_8dec_e8d6d5248083
has only substance units: false
name: _AA081045_1_m
constant: false
is encoded by: hsa:AA081045
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_1809cd18_f114_442e_b4d1_f209dbafbb11
initial amount: NaN
constant: false
is encoded by: hsa:27068
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: PPA2
is: SBO:0000252

metaR PSFLIPm
reactant: MODEL1310110030#
type: Reaction
name: phosphatidylserine flippase
is described by: ECO:0000269
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.1
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_f49ea43d_3b99_4268_ad5c_1ca41374f567
initial concentration: NaN
name: SLC26A8
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:116369
constant: false
is: SBO:0000252
boundary condition: true

metaR RE1519M
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
fast: false
kinetic law: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110030#
name: RE1519
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_05e11cd7_4808_49fb_95ac_e8b667972b1e
is encoded by: hsa:128
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: Q6IRT1
type: Species
name: ADH5
initial amount: NaN

metaR r1730
fast: false
is described by: ECO:0000000
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110030#
is: SBO:0000185

metaM ser L e
name: L-serine
boundary condition: false
is: HMDB00187
initial amount: NaN
type: Species
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_d0a4f20e_1e25_4b71_9f86_76e0ae7ec5b3
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6898
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: P17735
name: TAT

metaM oxa m
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
is: HMDB02329
boundary condition: false
initial amount: NaN
name: oxalate(2-)
is: CHEBI:30623
initial concentration: 1.0
type: Species
constant: false

metaR r1598
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaR RE0691C
reversible: true
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: RE0691
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR RE2079R
reactant: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000176
fast: false
name: RE2079
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
type: Reaction

metaM ura e
initial amount: NaN
is: HMDB00300
is: SBO:0000247
name: uracil
is: CHEBI:17568
type: Species
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM pram c
type: Species
is: CHEBI:58681
name: 5-Phospho-beta-D-ribosylamine
is: SBO:0000247
is: C03090
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01128

metaM didp c
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
constant: false
is: SBO:0000247
is: HMDB03536
is: CHEBI:28823
name: dIDP
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_75a8bd2f_5a10_402b_ae6b_a981c04b21a8
is encoded by: hsa:229
has only substance units: false
is: P05062
name: ALDOB
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR r1597
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110030#

metaR r2346
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport

metaM c226crn c
is: HMDB06510
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: cervonyl carnitine
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0

metaR LINKDEG4ly
is: SBO:0000176
reactant: MODEL1310110030#
name: degradation of proteoglycan linkage region, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110030#
reversible: false
kinetic law: MODEL1310110030#
is described by: ECO:0000000

metaR HSPASEly
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110030#
is described by: ECO:0000000
fast: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)

metaM val L e
type: Species
constant: false
is: HMDB00883
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16414
initial concentration: 1.0
initial amount: NaN

metaR RE0828E
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110030#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
reactant: MODEL1310110030#
name: RE0828
is described by: ECO:0000000
kinetic law: MODEL1310110030#
fast: false
reversible: false
product: MODEL1310110030#

metaR IDPtn
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110030#
reversible: true
name: IDP nuclear transport
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_a385f5e7_2cc2_4e54_a7e7_ecee89c5a338
name: PDE1C
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5137
type: Species
is: Q8NB10
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_ffc58dd2_4063_4de7_ab7d_84abd577ecb5
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:65263
is: SBO:0000252
constant: false
name: PYCRL
is: Q53H96
initial amount: NaN
initial concentration: NaN

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110030#
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reversible: false

metaR BTNDe
fast: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
reversible: false
name: biotinidase (biotin), extracellular
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
modifier: MODEL1310110030#
is described by: ECO:0000269
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#

metaM fuc1p L c
has only substance units: false
type: Species
is: CHEBI:28319
initial amount: NaN
name: L-Fucose 1-phosphate
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01265
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030

http://identifiers.org/biomodels.db/MODEL1310110030#_325a1c4a_c4fb_4f12_a0dd_87a3532b3133
initial concentration: NaN
name: SLC12A6
is: SBO:0000252
boundary condition: true
is: Q9UHW9
constant: false
has only substance units: false
type: Species
is encoded by: hsa:9990
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_595f670b_f5bd_4a23_a743_2a066cd8b14c
is encoded by: hsa:9045
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P50914
name: RPL14
type: Species

metaR r2356
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_1f20141d_d648_4221_bb0c_cf12343d59e2
initial concentration: NaN
is: P05091
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:217
name: ALDH2
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_efa0ccfa_2fb2_4278_957a_9f5887db45a8
constant: false
boundary condition: true
is: Q92903
type: Species
initial amount: NaN
is encoded by: hsa:1040
has only substance units: false
initial concentration: NaN
name: CDS1
is: SBO:0000252

metaM pmtcrn c
boundary condition: false
is: SBO:0000247
name: L-palmitoylcarnitine
constant: false
type: Species
initial concentration: 1.0
is: HMDB00222
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
has only substance units: false

metaR r0472
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaM ura c
constant: false
boundary condition: false
type: Species
is: HMDB00300
is: C00106
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17568
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: Uracil

metaM cmp e
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: CMP(2-)
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095

metaM co2 e
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
type: Species
name: CO2
initial amount: NaN
is: C00011
is: HMDB01967
is: CHEBI:16526
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaR DGK2m
fast: false
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110030#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)

metaM dctp n
initial amount: NaN
is: C00458
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: dCTP
type: Species
is: CHEBI:16311
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: HMDB00998

http://identifiers.org/biomodels.db/MODEL1310110030#_feea50fe_327a_4a68_b63c_ad0b8f8097c3
boundary condition: true
name: SLC5A7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:60482
is: SBO:0000252
type: Species
is: Q9GZV3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_d8eafd4a_5dd5_4901_a9f6_f9a946aa9adb
initial amount: NaN
name: PDE9A
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5152
has only substance units: false
constant: false
boundary condition: true

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_4ed59dc0_67c8_4105_a6d1_171fa038d6d4
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:84812
initial concentration: NaN
boundary condition: true
constant: false
is: Q9BRC7
has only substance units: false
name: PLCD4

http://identifiers.org/biomodels.db/MODEL1310110030#_d1ac49fe_e737_4c49_b0f8_626e3f64f694
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: HPS3
initial amount: NaN
is: SBO:0000252
is: Q969F9
is encoded by: hsa:84343
constant: false

metaR r2355
reversible: true
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000

metaM dhap x
is: C00111
is: CHEBI:57642
constant: false
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
has only substance units: false
name: Dihydroxyacetone phosphate
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR CSNATp
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
type: Reaction
reactant: MODEL1310110030#
reversible: true
is: SBO:0000176
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
modifier: MODEL1310110030#

metaM fald c
is: HMDB01426
is: CHEBI:16842
is: SBO:0000247
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR NTD9e
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:16325434 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110030#
name: 5'-nucleotidase (GMP), extracellular
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000254
fast: false
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_fd4ade10_0e98_4783_bebe_c6e0d2a2e9c4
is: Q9NR45
is encoded by: hsa:54187
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: NANS
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_51bf562b_ca69_4b51_abd2_bf13b1577a31
is encoded by: hsa:125061
constant: false
is: Q63HM1
initial amount: NaN
boundary condition: true
name: AFMID
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_e58c8ac5_1fc9_4d77_a225_fb4d4c00c469
constant: false
boundary condition: true
is: E7ET30
has only substance units: false
name: AK3
is encoded by: hsa:50808
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR NACHEX26ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
modifier: MODEL1310110030#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110030#

metaR r2354
reactant: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_ad65133c_766e_4d39_9ba6_e9ca9cb89446
has only substance units: false
boundary condition: true
is: P28329
constant: false
name: CHAT
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1103

metaR r1400
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false

metaR NDP7g
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
fast: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
kinetic law: MODEL1310110030#
is described by: ECO:0000269
reversible: false
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD

metaM ksi deg9 l
name: keratan sulfate I, degradation product 9
initial amount: NaN
type: Species
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:12936
is: HMDB00143
has only substance units: false

metaR RE3566C
type: Reaction
product: MODEL1310110030#
is: SBO:0000176
is described by: ECO:0000000
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
fast: false

metaM cmp c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
name: CMP
type: Species
has only substance units: false
is: C00055
boundary condition: false
is: HMDB00095

metaM co2 c
initial concentration: 1.0
is: HMDB01967
is: SBO:0000247
is: C00011
initial amount: NaN
name: CO2
is: CHEBI:3313
constant: false
type: Species
notes: FORMULA: CO2 CHARGE: 0
has only substance units: false
boundary condition: false

metaM C02528 r
is: HMDB00518
type: Species
is: SBO:0000247
name: chenodeoxycholate
initial concentration: 1.0
is: CHEBI:36234
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
initial amount: NaN
constant: false

metaR r2353
is described by: ECO:0000000
product: MODEL1310110030#
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_55d5c3f4_05e8_457f_b26c_e6b1f3b9db4f
initial concentration: NaN
is: SBO:0000252
name: PDE5A
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: O76074
is encoded by: hsa:8654
type: Species

metaR CSNATr
kinetic law: MODEL1310110030#
name: carnitine O-acetyltransferase
reactant: MODEL1310110030#
fast: false
reversible: true
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is described by: ECO:0000000

metaR r2352
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110030#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
fast: false
is: SBO:0000185
reversible: true

metaM 5mta c
boundary condition: false
is: SBO:0000247
is: C00170
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: HMDB01173
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17509
name: 5-Methylthioadenosine

metaR XYLtly
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
type: Reaction
product: MODEL1310110030#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_05089a40_320c_40c0_9cec_ffa383482a3d
is encoded by: hsa:2686
is: A0PJJ9
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: GGT7
initial amount: NaN

metaR ALASERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110030#
product: MODEL1310110030#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_a78a03f3_e7c1_4033_b6b1_7bb4ae69ed9d
constant: false
name: TXNRD1
is encoded by: hsa:7296
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM glu L c
boundary condition: false
type: Species
is: HMDB00148
name: L-glutamate(1-)
initial concentration: 1.0
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:29985

metaR RE2659R
reactant: MODEL1310110030#
name: RE2659
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#

metaR ASPPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
fast: false
name: aspartate intake by system ASCT-1 transporter
modifier: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_482ab90c_c320_4e43_8768_274c230815e1
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: BAAT
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q14032
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110030#_1e5bf512_faea_4f14_bd41_c8469fcf35dc
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:5152
initial concentration: NaN
name: PDE9A
boundary condition: true

metaR r0604
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
reversible: false

metaM methf c
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
type: Species
is: C00445
has only substance units: false
name: 5,10-Methenyltetrahydrofolate
is: HMDB01354
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
constant: false
boundary condition: false

metaM ksii core4 pre1 g
is: SBO:0000247
is: CHEBI:28067
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II biosynthesis, precursor 1
boundary condition: false
initial amount: NaN

metaR r0475
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110030#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
reactant: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_a761b856_f6d3_4589_a417_83d4380f208e
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4124
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: MAN2A1
is: Q16706

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM glu L e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29985
is: HMDB00148
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaR CYTK13n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is: SBO:0000176
modifier: MODEL1310110030#
product: MODEL1310110030#

metaM ser L m
is: HMDB00187
is: SBO:0000247
is: CHEBI:17115
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

metaR CSNATm
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
product: MODEL1310110030#
fast: false
is described by: ECO:0000269
name: carnitine O-aceyltransferase, mitochondrial
reactant: MODEL1310110030#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
reversible: true
is: SBO:0000176

metaR MEVK1x
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
fast: false
product: MODEL1310110030#
name: mevalonate kinase (atp)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.36
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
is described by: ECO:0000134

metaM cs b deg2 l
is: HMDB00812
is: CHEBI:16953
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2

metaR r0474
reactant: MODEL1310110030#
product: MODEL1310110030#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_bdb8ac80_cea3_42ea_8b91_cfe4a0ce7cbe
has only substance units: false
initial concentration: NaN
name: _AI824319_1_r
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:AI824319
boundary condition: true
initial amount: NaN

metaM gam6p c
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01254
is: CHEBI:12962
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
boundary condition: false
constant: false
name: D-Glucosamine 6-phosphate

metaR TYRPHELAT2tc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR 3SPYRSP
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
type: Reaction
reversible: false
kinetic law: MODEL1310110030#
product: MODEL1310110030#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_b973b5db_5698_4fef_a542_5f485f9dfd43
is encoded by: hsa:1327
is: SBO:0000252
boundary condition: true
name: COX4I1
initial concentration: NaN
constant: false
initial amount: NaN
is: P13073
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_dc0d02a9_0f42_419c_a284_01b3034923c9
constant: false
is encoded by: hsa:3707
initial amount: NaN
is: SBO:0000252
type: Species
is: P27987
name: ITPKB
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM trdrd c
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: Reduced thioredoxin
has only substance units: false
constant: false
is: C00342
is: CHEBI:15967

metaR SERDGLNexR
product: MODEL1310110030#
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110030#
fast: false
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_9b99d0a8_12f2_47ee_96d0_63a0ee3b3bb5
constant: false
name: DGUOK
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: E5KSL6
initial concentration: NaN
is encoded by: hsa:1716

metaR DUDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dUDP nuclear transport
type: Reaction
reactant: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
fast: false
product: MODEL1310110030#

metaM c226crn m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: cervonyl carnitine
initial amount: NaN
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
is: HMDB06510

http://identifiers.org/biomodels.db/MODEL1310110030#_b4aaaac2_213b_425a_8122_910d9a2129a6
is encoded by: hsa:U52111
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: _U52111_1_c
boundary condition: true
initial concentration: NaN

metaR ITPtn
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
name: ITP nuclear transport
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_8be9c183_2a3b_405e_951c_848a5a037c35
is: P30048
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: PRDX3
is encoded by: hsa:10935
initial concentration: NaN

metaR GLCNACT L
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
is: SBO:0000176
reversible: false
reactant: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
fast: false
is described by: ECO:0000000

metaR FAOXC18480m
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
name: Beta oxidation of fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110030#

metaM 4mop c
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
is: CHEBI:17865
initial amount: NaN
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00695
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_3359788b_894b_43eb_9e8f_5408ad4fa8db
has part: P15531
name: NME1:NME2
has part: P22392
boundary condition: true
type: Species
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4831
constant: false
is encoded by: hsa:4830

metaM co2 m
is: C00011
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: CO2
is: CHEBI:16526
is: HMDB01967

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
type: Reaction
reactant: MODEL1310110030#
is described by: ECO:0000000
product: MODEL1310110030#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
fast: false
kinetic law: MODEL1310110030#

metaM 5mta e
initial concentration: 1.0
notes: FORMULA: C11H15N5O3S CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: C00170
name: 5-Methylthioadenosine
has only substance units: false
is: HMDB01173
initial amount: NaN
is: CHEBI:17509

metaR DNDPt36m
name: dGDP transport via dCDP antiport
is described by: ECO:0000269
reactant: MODEL1310110030#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
fast: false
modifier: MODEL1310110030#

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57444
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 12(S)-HPETE(1-)
is: HMDB04243
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_2bc3c89a_d5d4_4bed_8b4e_fcf12329f032
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: P04745
name: AMY1C
is encoded by: hsa:278
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_876e14bb_2361_4333_9a3e_c93831640d81
name: _642502_1_c
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:642502
type: Species

metaR BILDGLCURt
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110030#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110030#

metaM hpdcacrn c
initial concentration: 1.0
name: heptadecanoyl carnitine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
type: Species
is: HMDB06210
boundary condition: false
has only substance units: false
constant: false

metaM dhf c
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01056
is: C00415
is: SBO:0000247
constant: false
is: CHEBI:57451
has only substance units: false

metaR Htx
reversible: true
type: Reaction
is described by: ECO:0000000
name: H transporter, peroxisome
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ

metaM xan c
is: C00385
type: Species
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
is: HMDB00292
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: Xanthine

metaM 4mop e
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: HMDB00695
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: CHEBI:17865
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r0365
reactant: MODEL1310110030#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
product: MODEL1310110030#
modifier: MODEL1310110030#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reversible: false
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110030#_46e3d267_ef1f_4bf6_a435_ccf0a5db39b7
constant: false
is encoded by: hsa:3030
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: E9KL44
name: HADHA
has only substance units: false

metaR FAOXC1811603m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110030#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
name: Beta oxidation fatty acid
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_f583cefa_71a0_4e62_bf08_133116540680
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:513
is: SBO:0000252
initial concentration: NaN
name: ATP5D
constant: false
has only substance units: false

metaR PGMT
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
name: phosphoglucomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110030#
fast: false

metaR UDPGLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_659e9177_4a45_4bf7_adc7_63585589027f
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q8N0W3
is encoded by: hsa:197258
name: FUK
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_c39d730d_78ff_45b0_a75a_8e747e16d0b9
type: Species
is encoded by: hsa:292
name: SLC25A5
is: Q6NVC0
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR NDPK5n
is: SBO:0000176
product: MODEL1310110030#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM pnto R c
is: CHEBI:7916
type: Species
name: (R)-Pantothenate
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00210

metaR ARACHDt2
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110030#
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185

metaM ksii core4 pre5 g
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C69H112N6O48X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 5
is: C00130
is: CHEBI:58053
initial concentration: 1.0
type: Species

metaM dhor S c
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
initial concentration: 1.0
is: CHEBI:30864
is: HMDB03349
constant: false
has only substance units: false
name: (S)-dihydroorotate
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0033
modifier: MODEL1310110030#
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_c9c9eda1_e6be_4a20_bd8e_65de5e25e656
has only substance units: false
is encoded by: hsa:5150
type: Species
is: Q13946
constant: false
name: PDE7A
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_275ddbb5_0654_422b_b0bf_094a3500d653
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: GBA
is encoded by: hsa:2629
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_77124e66_aac2_4665_a632_de186d416a38
name: _BE966236_1_m
is encoded by: hsa:BE966236
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5d304efc_6699_407d_aeb8_89b61cf93bca
is: P04040
is encoded by: hsa:847
has only substance units: false
constant: false
name: CAT
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_8e95f8ee_380a_405d_b22c_9ad9e308b1f1
is encoded by: hsa:AI348006
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: _AI348006_1_c

metaR GLNTHRNaEx
is described by: ECO:0000269
modifier: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_6a7f6ec1_7a6f_4790_9d8f_ef76000a0260
is encoded by: hsa:51302
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CYP39A1
initial concentration: NaN
constant: false
is: Q9NYL5

metaM CE0785 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5041
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
is: C01936
initial concentration: 1.0
has only substance units: false
constant: false

metaM cyan e
initial concentration: 1.0
is: CHEBI:18407
is: SBO:0000247
initial amount: NaN
is: HMDB02084
type: Species
boundary condition: false
constant: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false

metaR FOLTle
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: folate uptake into the enterocytes
type: Reaction

metaR HAS2
modifier: MODEL1310110030#
is described by: ECO:0000269
product: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.212
kinetic law: MODEL1310110030#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110030#_edbcdc68_d4ea_4d26_8a1e_b864d46776ed
initial concentration: NaN
has only substance units: false
name: GPX4
type: Species
constant: false
boundary condition: true
is encoded by: hsa:2879
initial amount: NaN
is: SBO:0000252
is: P36969

http://identifiers.org/biomodels.db/MODEL1310110030#_5dd2dce0_ea58_4977_b19a_08e66f19bb2d
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
name: GLRX2
is encoded by: hsa:51022
initial amount: NaN
initial concentration: NaN

metaM xyl D c
is: SBO:0000247
constant: false
is: CHEBI:15936
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: aldehydo-D-xylose
type: Species

metaR r2005
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
reversible: false
modifier: MODEL1310110030#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185

metaM xol27oh m
initial amount: NaN
name: 26-hydroxycholesterol
is: HMDB02103
constant: false
initial concentration: 1.0
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaM pnto R e
is: SBO:0000247
name: (R)-Pantothenate
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00210
is: CHEBI:7916
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_d25ee46d_af0b_449a_88db_bee6f985a5bb
is: SBO:0000252
is encoded by: hsa:2531
is: Q06136
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: KDSR

metaR AG13T10g
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110030#

metaR r1050
type: Reaction
reversible: true
product: MODEL1310110030#
name: Vesicular transport
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110030#_81f1542b_2399_4935_80e4_b8d954813d8b
type: Species
constant: false
is: Q6LEN6
name: CHAT
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_6441fe21_1cfd_4060_91c0_bc852f1a78c5
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:51
constant: false
type: Species
is: SBO:0000252
is: Q15067
name: ACOX1

metaM methf m
type: Species
is: CHEBI:57455
constant: false
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
name: (6R)-5,10-methenyltetrahydrofolate
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM cyan c
initial concentration: 1.0
is: CHEBI:18407
is: SBO:0000247
name: hydrogen cyanide
boundary condition: false
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_cce60fb5_a8b9_451d_a335_d4bf926c433f
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6576
is: D9HTE9
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC25A1

metaM ksii core4 pre10 g
initial amount: NaN
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
constant: false
type: Species
is: CHEBI:28067
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR OCCOAtm
kinetic law: MODEL1310110030#
product: MODEL1310110030#
name: Octanoyl-CoA transport, diffusion
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction

metaR r1051
fast: false
product: MODEL1310110030#
is described by: ECO:0000000
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110030#
type: Reaction
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000185

metaM cmp g
name: CMP(2-)
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00095
initial amount: NaN
is: CHEBI:60377
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_6362b478_da70_49e6_9429_9e0783498e02
initial concentration: NaN
boundary condition: true
is: B3KMA6
is encoded by: hsa:2181
type: Species
is: SBO:0000252
initial amount: NaN
name: ACSL3
constant: false
has only substance units: false

metaM xyl D e
has only substance units: false
name: aldehydo-D-xylose
is: CHEBI:15936
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110030#

metaM gdp n
is: CHEBI:58189
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: GDP(3-)
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
constant: false
initial concentration: 1.0

metaR CYSASNNaEx
name: L-cysteine/L-asparagine Na-dependent exchange (Cys-L in)
product: MODEL1310110030#
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_6458f302_acd9_4fe5_be32_4ee685642cc7
name: SLC2A14
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8TDB8
has only substance units: false
is encoded by: hsa:144195
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_aaa8a4c0_543d_40d1_929a_c17bac6154b9
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
is: Q5T4W8
constant: false
name: ST3GAL3
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM hretn n
is: HMDB06254
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H27O3 CHARGE: -1
boundary condition: false
has only substance units: false
name: 4 hydroxy retinoic acid
type: Species
is: SBO:0000247

metaM hepcoa m
boundary condition: false
name: heptanoylcoa
is: SBO:0000247
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: HMDB12969
type: Species
initial concentration: 1.0
has only substance units: false

metaM tchola c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:36257
is: HMDB00036
name: taurocholic acid
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_a9532a7a_7962_4281_add0_fa94837dc374
has only substance units: false
boundary condition: true
is encoded by: hsa:35
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: P16219
name: ACADS
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_e0e01a82_6145_4274_97c6_1c2e86e10569
boundary condition: true
type: Species
is: Q9UBM7
is encoded by: hsa:1717
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: DHCR7
initial concentration: NaN

metaM trdrd m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Reduced thioredoxin
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967

metaR H2Oter
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
name: H2O endoplasmic reticulum transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_314f4417_e22f_48f9_be4d_798d244ef95c
is: SBO:0000252
constant: false
boundary condition: true
name: GPX7
is: Q96SL4
is encoded by: hsa:2882
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_0071ee54_1b26_4862_bb66_89f4d2b92d39
initial amount: NaN
constant: false
is: Q9NS18
is: SBO:0000252
is encoded by: hsa:51022
boundary condition: true
name: GLRX2
has only substance units: false
initial concentration: NaN
type: Species

metaR CYANt
product: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: Cyanide transport via diffusion (extracellular to cytosol)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR CSNAT3x
reactant: MODEL1310110030#
reversible: true
fast: false
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
modifier: MODEL1310110030#
name: carnitine O-aceyltransferase, peroxisomal
product: MODEL1310110030#

metaM HC01231 c
is: SBO:0000247
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_77ad99d6_fb85_4b59_89b1_3ae1457075af
is encoded by: hsa:122970
type: Species
boundary condition: true
is: Q8N9L9
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: ACOT4
initial concentration: NaN

metaR DURIPP
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
kinetic law: MODEL1310110030#
is: SBO:0000176
product: MODEL1310110030#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
modifier: MODEL1310110030#

metaM HC02210 e
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:34939
name: prostaglandin-d3
has only substance units: false
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0

metaR LINOFATPtc
kinetic law: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM thf c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
is: SBO:0000247
type: Species
is: HMDB01846
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_2df760ec_bc4b_425f_b5a3_dd367a025c6b
name: PDE9A
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:5152
constant: false
initial amount: NaN

metaR SCPx
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
kinetic law: MODEL1310110030#
name: peroxisomal thiolase 2
reversible: false
modifier: MODEL1310110030#

metaR ASPNATm
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
name: aspartate N-acetyltransferase, mitochondrial
reversible: false
kinetic law: MODEL1310110030#
type: Reaction

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR XYLt
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
name: D-xylose reversible transport
fast: false
kinetic law: MODEL1310110030#
is described by: ECO:0000269
modifier: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
type: Reaction
product: MODEL1310110030#

metaR ADK3m
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: adentylate kinase (GTP)
modifier: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaR 3SALATAi
reactant: MODEL1310110030#
name: 3-sulfino-alanine transaminase (irreversible)
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
product: MODEL1310110030#
is described by: ECO:0000304
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
type: Reaction
is: SBO:0000176

metaM ksi pre28 g
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
is: HMDB00175
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: C00130

metaR LPCHOLt
name: lysophosphatidylcholine transport
is: SBO:0000185
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
fast: false
product: MODEL1310110030#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110030#_dac657df_9dc4_45cf_8262_e60d4a9b2e1b
name: PLCXD2
is encoded by: hsa:257068
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q0VAA5

metaM ksi deg18 l
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
constant: false
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 18
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110030#_212539d8_3343_4563_b9ee_67b97c03b177
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ND4
boundary condition: true
has only substance units: false
constant: false
is: P03905
type: Species
is encoded by: hsa:4538

http://identifiers.org/biomodels.db/MODEL1310110030#_6ac26405_5714_4635_a198_d521e2ae8c17
type: Species
constant: false
is encoded by: hsa:8818
is: O94777
name: DPM2
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM tchola e
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0
name: taurocholic acid
initial amount: NaN
boundary condition: false
type: Species

metaM tmndnccoa c
has only substance units: false
is: SBO:0000247
is: HMDB06514
constant: false
boundary condition: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
name: timnodonyl coenzyme A
initial concentration: 1.0

metaR DGAT
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
product: MODEL1310110030#
modifier: MODEL1310110030#
reversible: false
name: diacylglycerol acyltransferase
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.20
reactant: MODEL1310110030#
is described by: ECO:0000000

metaM co2 x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
name: carbon dioxide
is: SBO:0000247
is: HMDB01967
constant: false
boundary condition: false
type: Species
is: CHEBI:16526

http://identifiers.org/biomodels.db/MODEL1310110030#_4dfa8325_851a_4e9a_bace_a442011acf85
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: PANK2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110030#_7a4bfe0e_1f7c_4fd6_820a_778b48119c65
initial amount: NaN
is: A8K4A0
constant: false
is: SBO:0000252
is encoded by: hsa:411
type: Species
has only substance units: false
name: ARSB
boundary condition: true
initial concentration: NaN

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110030#
reversible: true
kinetic law: MODEL1310110030#
product: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_0b174b23_768d_41c7_8e24_563b9bb88f4e
has only substance units: false
boundary condition: true
name: SLC2A6
initial concentration: NaN
is encoded by: hsa:11182
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: Q9UGQ3

metaR UDPGLCAter
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
modifier: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
type: Reaction
reversible: true
fast: false
product: MODEL1310110030#
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_64ec90e8_e508_4823_b2dd_96f180fcff4f
is encoded by: hsa:55650
name: PIGV
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: Q9NUD9

metaR HDCAter
type: Reaction
reactant: MODEL1310110030#
name: palmitate ER export
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
fast: false

metaR FERO
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110030#
is described by: ECO:0000134
fast: false
product: MODEL1310110030#
name: ferroxidase
modifier: MODEL1310110030#

metaR GBA
name: Glucosylceramidase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110030#
reversible: false
reactant: MODEL1310110030#
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110030#_b9d0b42b_fec9_4952_9d8c_928af878e0a7
name: CPT1B
has only substance units: false
is encoded by: hsa:1375
type: Species
boundary condition: true
constant: false
is: Q53FV7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110030#_2e534ce3_fa62_4461_ba81_32ac2bc68a9d
is: B7Z6Q4
type: Species
is encoded by: hsa:3612
initial amount: NaN
is: SBO:0000252
constant: false
name: IMPA1
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM adp m
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:456216
is: C00008
constant: false
name: ADP

http://identifiers.org/biomodels.db/MODEL1310110030#_2407d855_07b8_418d_bcb6_f83fd17956b9
name: DPYS
has only substance units: false
initial concentration: NaN
is: Q14117
type: Species
is encoded by: hsa:1807
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR O2Stm
product: MODEL1310110030#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110030#
fast: false
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110030#

metaR GAO2g
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reversible: false
type: Reaction
modifier: MODEL1310110030#
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
product: MODEL1310110030#

metaR r2314
fast: false
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction

metaM acgam l
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: N-acetyl-D-glucosamine
boundary condition: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
initial amount: NaN

metaR BAMPPALDOX
fast: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
type: Reaction
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110030#
is described by: ECO:0000212
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110030#_d297071e_fd3d_49e0_b044_3ccc05f34cd2
is: Q9Y5P4
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10087
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: COL4A3BP

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM ksii core2 pre2 g
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00175
is: C00130
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
notes: FORMULA: C39H63N3O28X CHARGE: -1
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR MI13PP
is described by: ECO:0000000
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110030#
name: inositol-1,3-bisphosphate 3-phosphatase

metaR GGNG
is version of: http://identifiers.org/ec-code/2.4.1.11
is: SBO:0000176
type: Reaction
reversible: false
name: glycogenin self-glucosylation
kinetic law: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.4.1.186
notes: GENE_ASSOCIATION: (8908.1) and (2998.1) or (2998.1) and (2992.1) or (2997.1) and (2992.1) or (8908.1) and (2997.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15238248,PMID:8602861,PMID:9857012 NOTES:NCD
product: MODEL1310110030#
modifier: MODEL1310110030#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110030#

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110030#
is: SBO:0000176
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
type: Reaction
name: Diacylglycerol phosphate kinase (homo sapiens)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.107
reactant: MODEL1310110030#

metaM 2dr5p c
initial amount: NaN
is: CHEBI:57651
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ump g
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00288
name: UMP(2-)
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

metaM 3hddcoa m
is: C01942
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB13028
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial amount: NaN

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaR PROSTGH2t
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#
name: Prostaglandin H2 transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
kinetic law: MODEL1310110030#

metaM paps c
is: CHEBI:58339
constant: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
boundary condition: false
is: SBO:0000247

metaR r2313
fast: false
is: SBO:0000185
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110030#
kinetic law: MODEL1310110030#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_1f051074_7767_4619_8a35_0371600ff6f3
is encoded by: hsa:1716
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: E5KSL6
name: DGUOK

metaM CE1943 e
type: Species
has only substance units: false
is: CHEBI:52324
name: spermidine dialdehyde
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943

metaM paps g
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58339
has only substance units: false

metaR M16NTg
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110030#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reactant: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.143

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (S)-Hydroxyhexanoyl-CoA
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:28276

metaR 10FTHFtm
is: SBO:0000185
product: MODEL1310110030#
fast: false
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaR CERT1rt
is: SBO:0000185
product: MODEL1310110030#
fast: false
reactant: MODEL1310110030#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
modifier: MODEL1310110030#
type: Reaction
name: ceramide transport protein
is described by: ECO:0000304
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_7b01609a_b5a6_47ad_8ea5_d068d2263235
is: E9KL42
is encoded by: hsa:641371
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: ACOT1

metaM nadp m
type: Species
boundary condition: false
is: C00006
is: HMDB00217
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
is: CHEBI:58349
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110030#_519063ac_b72b_4647_90cf_fd707ad64a4d
boundary condition: true
is: Q9H2U2
is encoded by: hsa:27068
initial amount: NaN
is: SBO:0000252
constant: false
name: PPA2
type: Species
initial concentration: NaN
has only substance units: false

metaR r0178
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:

metaR r2316
fast: false
product: MODEL1310110030#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110030#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM bilirub c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
has only substance units: false
boundary condition: false
is: HMDB00054
initial concentration: 1.0
name: bilirubin(2-)

metaR ACGALtly
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
type: Reaction
name: N-acetyl-galactosamine lysosomal efflux
product: MODEL1310110030#
reactant: MODEL1310110030#

metaM ump e
has only substance units: false
type: Species
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00288
constant: false
name: UMP(2-)
is: SBO:0000247

metaM adp n
name: ADP(3-)
boundary condition: false
has only substance units: false
type: Species
is: HMDB01341
constant: false
is: CHEBI:456216
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR r1540
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: false
product: MODEL1310110030#
fast: false
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
modifier: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaR r2315
reactant: MODEL1310110030#
reversible: true
is described by: ECO:0000000
product: MODEL1310110030#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_c62eeb3e_94dd_413c_97b7_e2ac4b328fff
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q99624
constant: false
name: SLC38A3
is encoded by: hsa:10991
type: Species
initial concentration: NaN
is: SBO:0000252

metaR MALtm
is: SBO:0000185
type: Reaction
name: malate transport, mitochondrial
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
kinetic law: MODEL1310110030#
modifier: MODEL1310110030#
product: MODEL1310110030#
reactant: MODEL1310110030#

metaR M1316Mg
is: SBO:0000176
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.114
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110030#
kinetic law: MODEL1310110030#

metaR r2318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110030#
is described by: ECO:0000000
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185
type: Reaction
reversible: true

metaM noncoa m
has only substance units: false
boundary condition: false
constant: false
is: C01942
initial amount: NaN
is: SBO:0000247
is: HMDB13028
initial concentration: 1.0
type: Species
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
name: nonanoylcoa

metaR DNDPt30m
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110030#
reversible: false
name: dCDP transport via ADP antiport
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
fast: false

metaR FUMSO4tm
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
is: SBO:0000185
type: Reaction
product: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
name: Fumarate:sulfate antiport, mitochondrial

metaM nadp c
initial amount: NaN
is: CHEBI:58349
has only substance units: false
is: HMDB00217
is: SBO:0000247
type: Species
is: C00006
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate

metaM HC01603 c
is: SBO:0000247
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
is: C00234
type: Species
has only substance units: false
constant: false
boundary condition: false

metaM tmndnccoa m
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB06514
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
name: timnodonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110030#_39f9d96c_1473_4e3d_a394_ff00beb56ddb
initial concentration: NaN
name: NDUFB1
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4707
boundary condition: true
is: O75438
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110030#_fd17bb14_aef8_4216_90f4_7781bbca06f3
is: P51160
initial amount: NaN
name: PDE6C
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:5146
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_70d77911_b56e_4d07_9ed0_e5aa47f59a7b
is encoded by: hsa:T83654
has only substance units: false
constant: false
name: _T83654_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR 3MOPte
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110030#
is: SBO:0000185
kinetic law: MODEL1310110030#
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_49d40dbd_0d84_412c_999a_556f966154cd
constant: false
initial concentration: NaN
is encoded by: hsa:440
name: ASNS
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: E9PCX6
boundary condition: true
type: Species

metaM cmp n
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00095
initial amount: NaN
name: CMP(2-)
constant: false
is: CHEBI:60377
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110030#_4b34c131_01bf_4bb2_8a0b_cfea1fcda5a6
type: Species
has only substance units: false
initial amount: NaN
name: NME3
constant: false
is encoded by: hsa:4832
is: Q13232
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r1546
reactant: MODEL1310110030#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110030#
reversible: true
is: SBO:0000185
product: MODEL1310110030#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_c84ef1a7_5362_4e7b_b7bf_199f8aae86a4
type: Species
is: P17516
name: AKR1C4
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1109
is: SBO:0000252
has only substance units: false

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r2317
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110030#
type: Reaction
reactant: MODEL1310110030#
product: MODEL1310110030#

metaM m4mpdol L c
is: CHEBI:37633
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_770963ca_f54d_4a96_8b4b_d19d2024f675
name: GLUD2
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2747
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: P49448

http://identifiers.org/biomodels.db/MODEL1310110030#_a12770a7_0130_42cc_b908_b0a6cc3100b7
is encoded by: hsa:10317
type: Species
boundary condition: true
has only substance units: false
constant: false
name: B3GALT5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR SERALANaEx
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185

metaR LNLCCRNt
kinetic law: MODEL1310110030#
is: SBO:0000185
product: MODEL1310110030#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110030#
type: Reaction
name: transport into the mitochondria (carnitine)
fast: false
reactant: MODEL1310110030#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110030#_9e5bc571_124c_487a_8f77_e10ddf3acf88
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q9GZX3
initial concentration: NaN
boundary condition: true
name: CHST6
is encoded by: hsa:4166

metaR r0917
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110030#
is described by: ECO:0000000
kinetic law: MODEL1310110030#
type: Reaction
reversible: true
reactant: MODEL1310110030#

metaR r0591
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reversible: true
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR CHATn
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reversible: true
reactant: MODEL1310110030#
modifier: MODEL1310110030#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110030#
is: SBO:0000176
type: Reaction
name: Choline O-acetyltransferase
kinetic law: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_ba813e5c_c93d_481d_bf95_b6dad9a2ae28
name: B4GALT1
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P15291
constant: false
initial concentration: NaN
is encoded by: hsa:2683

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110030#
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reversible: false
reactant: MODEL1310110030#
fast: false

metaM dolmanp U c
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15809
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false

metaM bilirub e
is: HMDB00054
initial concentration: 1.0
constant: false
is: CHEBI:57977
boundary condition: false
type: Species
initial amount: NaN
name: bilirubin(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110030#_ec066a14_fe4e_4802_b075_b7880f18ccca
constant: false
name: SYNJ2
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: O15056
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8871

metaM gdp g
initial concentration: 1.0
name: GDP(3-)
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58189
is: HMDB01201
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR r1696
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110030#
reactant: MODEL1310110030#
modifier: MODEL1310110030#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_9249ec79_bc2b_4a07_bd25_038f952f7637
initial amount: NaN
is encoded by: hsa:112
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: ADCY6
is: O43306
initial concentration: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR GPAM hs
fast: false
modifier: MODEL1310110030#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: glycerol-3-phosphate acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.15
is described by: ECO:0000000
kinetic law: MODEL1310110030#
product: MODEL1310110030#

http://identifiers.org/biomodels.db/MODEL1310110030#_52cfd7c3_46ba_443d_aa18_ea17bfa7eff7
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O95299
is encoded by: hsa:4705
boundary condition: true
name: NDUFA10
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_6bbd142e_8c86_49b9_8e53_ed7740f59336
is: SBO:0000252
type: Species
is encoded by: hsa:53947
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: A4GALT
is: Q9NPC4
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110030#_0e7e06f3_a4d3_4754_b6b7_d170a79e83d2
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4701
initial concentration: NaN
constant: false
name: NDUFA7
is: Q6FG42
initial amount: NaN

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_687dc65b_af7a_46dc_b75a_0f7ea2280b98
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7108
is: O76062
initial concentration: NaN
has only substance units: false
name: TM7SF2
constant: false
type: Species

metaR r0594
reactant: MODEL1310110030#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110030#
is described by: ECO:0000000
fast: false
product: MODEL1310110030#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110030#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110030#_83dd2f22_3840_4c1f_a436_2d8da8118e60
has only substance units: false
is: SBO:0000252
name: GALK2
initial concentration: NaN
type: Species
is encoded by: hsa:2585
constant: false
initial amount: NaN
boundary condition: true

metaM ksi deg29 l
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:12936
constant: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: HMDB00143
name: keratan sulfate I, degradation product 29

metaR DIDPtn
fast: false
reactant: MODEL1310110030#
product: MODEL1310110030#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110030#
reversible: true
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110030#_5aac9b33_d0bc_4d71_9108_0e0bbcc2578a
initial concentration: NaN
is encoded by: hsa:1738
has part: Q02218
is encoded by: hsa:1743
is: SBO:0000297
has part: P36957
is encoded by: hsa:8050
is encoded by: hsa:4967
boundary condition: true
has part: O00330
has only substance units: false
has part: P09622
initial amount: NaN
constant: false
name: DLD:DLST:OGDH:PDHX
type: Species

http://identifiers.org/biomodels.db/MODEL1310110030#_a7adf5db_93fb_446d_bf34_48f0c16922aa
name: UEVLD
type: Species
is: SBO:0000252
is: Q8IX04
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55293
boundary condition: true
constant: false
initial amount: NaN

metaR r1544
is described by: ECO:0000000
kinetic law: MODEL1310110030#
reversible: true
reactant: MODEL1310110030#
product: MODEL1310110030#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR SGPL12r
is: SBO:0000176
type: Reaction
fast: false
name: Sphingosine-1-phosphate lyase
reversible: false
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
modifier: MODEL1310110030#
reactant: MODEL1310110030#

metaR r2319
is described by: ECO:0000000
product: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110030#
kinetic law: MODEL1310110030#
fast: false
is: SBO:0000185

metaM CE4792 m
is: CHEBI:15748
boundary condition: false
is: HMDB00127
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110030#_5dbaa6a3_d398_4042_a0b3_262ad4cc4605
is encoded by: hsa:594
name: BCKDHB
constant: false
initial concentration: NaN
has only substance units: false
is: P21953
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110030#_bb914ad7_93b6_4b53_b1fb_10681c9694cd
initial amount: NaN
type: Species
is encoded by: hsa:5476
initial concentration: NaN
is: P10619
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: CTSA

metaM ump r
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: SBO:0000247
is: HMDB00288
constant: false
name: UMP
is: CHEBI:57865
boundary condition: false
has only substance units: false
type: Species

metaM thf m
has only substance units: false
initial concentration: 1.0
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
is: SBO:0000247

metaR r0915
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110030#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110030#
kinetic law: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

metaR Rtotaltl
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
kinetic law: MODEL1310110030#
type: Reaction
product: MODEL1310110030#
reactant: MODEL1310110030#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ

metaM ditp c
type: Species
is: HMDB03537
is: SBO:0000247
name: dITP(4-)
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:61382
has only substance units: false