metaR RE1533M
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
name: RE1533
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_f2eaa894_28a1_447e_81b5_bc5c245eeaee
constant: false
is: Q1EHB4
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:159963
name: SLC5A12

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM co2 c
name: CO2
is: CHEBI:3313
boundary condition: false
is: HMDB01967
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
is: C00011
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaM cmp c
is: C00055
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
initial concentration: 1.0
name: CMP
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB00095
is: CHEBI:60377

metaR CYTK5
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR r2362
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR r0940
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110029#
reversible: true
name: Free diffusion
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR MALtm
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110029#
reactant: MODEL1310110029#
name: malate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
is: SBO:0000185

metaM prostgi2 e
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
type: Species
initial amount: NaN
has only substance units: false
name: prostaglandin I2(1-)
is: HMDB01335
is: SBO:0000247
boundary condition: false

metaR PROSTGH2t
is described by: ECO:0000269
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
type: Reaction
name: Prostaglandin H2 transport
reversible: true
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#

metaR NP1
name: nucleotide phosphatase
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9b516fce_8152_4ec9_bd55_36eb5a2f8d99
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: O43674
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4711
name: NDUFB5

http://identifiers.org/biomodels.db/MODEL1310110029#_e52d2981_beab_4d88_8abb_507e08612a09
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:766
boundary condition: true
type: Species
name: CA7
is: Q86YU0
is: SBO:0000252
initial amount: NaN

metaM i c
boundary condition: false
has only substance units: false
is: HMDB12238
is: SBO:0000247
initial concentration: 1.0
name: iodide
initial amount: NaN
type: Species
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382

metaM h e
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
name: proton
type: Species
is: CHEBI:24636
boundary condition: false
is: SBO:0000247
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
initial concentration: 1.0

metaR TSTSTERONEtr
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110029#
name: testosterone intracellular transport
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_a433646e_c3c2_4136_aada_b43956db46f1
is encoded by: hsa:10991
initial concentration: NaN
name: SLC38A3
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q99624

metaM pe hs c
initial amount: NaN
type: Species
is: CHEBI:16038
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
name: phosphatidylethanolamine
initial concentration: 1.0
is: SBO:0000247

metaR SPMTDe
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
name: SPMTDe
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
reversible: true

metaM pep m
name: Phosphoenolpyruvate
constant: false
has only substance units: false
is: C00074
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00263
initial amount: NaN
is: CHEBI:18021
boundary condition: false

metaR GGH 6THFe
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110029#
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176

metaM datp n
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00131
name: dATP
type: Species
is: CHEBI:61404
boundary condition: false
initial amount: NaN
is: HMDB01532
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false

metaR r0483
type: Reaction
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
reversible: true

metaR r2363
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR CITtbm
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
is: SBO:0000185
name: citrate transport, mitochondrial
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
fast: false
product: MODEL1310110029#

metaR CYTK6
name: cytidylate kinase (CMP,CTP)
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110029#_daf89518_c877_4603_802d_2747d8aa2a91
has only substance units: false
constant: false
name: VNN2
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8875
is: O95498
boundary condition: true

metaM HC02205 c
is: CHEBI:28099
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: prostaglandin-b2
has only substance units: false
boundary condition: false

metaM xol7a r
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: CHEBI:1296
initial amount: NaN
name: 20-hydroxycholesterol
boundary condition: false
is: HMDB01496
type: Species
initial concentration: 1.0
has only substance units: false

metaR r0941
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
name: Free diffusion
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#

metaM CE4876 r
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
name: delta12-Prostaglandin J2
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12947
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_f7869e0b_b097_4a07_89bc_4fa2ce4d51f2
constant: false
is: Q96C36
name: PYCR2
is encoded by: hsa:29920
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaM malthp e
initial amount: NaN
is: C01936
constant: false
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
boundary condition: false
name: maltoheptaose
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_a093f876_8514_4330_b1f8_1caddba9cbef
initial amount: NaN
constant: false
boundary condition: true
name: AK4
has only substance units: false
type: Species
is encoded by: hsa:205
is: SBO:0000252
initial concentration: NaN
is: P27144

http://identifiers.org/biomodels.db/MODEL1310110029#_ee4f07ff_5465_424b_bc9c_e209468256d3
name: COX6B2
is encoded by: hsa:125965
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q6YFQ2

http://identifiers.org/biomodels.db/MODEL1310110029#_f5c2740f_d5e2_4ae8_868f_1738d04153e8
has only substance units: false
name: VNN3
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55350
initial concentration: NaN

metaM tsul e
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: HMDB00257
is: CHEBI:16094

http://identifiers.org/biomodels.db/MODEL1310110029#_a8b90155_e4fc_4c10_a1cd_a87b857fdd72
is encoded by: hsa:AI769281
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: _AI769281_1_e
initial concentration: NaN

metaM dcyt n
is: HMDB00014
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 2'-deoxycytidine
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
boundary condition: false

metaR ATPtx
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: ATP transporter, peroxisomal
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR CYTK7
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
name: cytidylate kinase (CMP,UTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
reversible: true

metaM co2 e
name: CO2
is: HMDB01967
initial amount: NaN
boundary condition: false
is: C00011
is: SBO:0000247
is: CHEBI:16526
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false

metaM cmp e
name: CMP(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
is: HMDB00095
has only substance units: false
is: CHEBI:60377

metaR r2364
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false

metaR r0942
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
type: Reaction
reversible: true

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: SBO:0000247
is: CHEBI:24636
constant: false
boundary condition: false
name: proton
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM betald c
initial concentration: 1.0
is: CHEBI:15710
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
type: Species
is: HMDB01252
constant: false

metaM i e
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
boundary condition: false
is: HMDB12238
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: iodide
is: CHEBI:16382

metaM lnlc c
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
is: HMDB00673
name: linoleate
is: CHEBI:30245
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_3cb4c230_3fe6_4193_86e4_c7da7af507db
constant: false
is: SBO:0000252
name: AKR1A1
is encoded by: hsa:10327
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR CYTK8
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: cytidylate kinase (CMP,dATP)

metaR r2365
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM nh4 m
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28938
initial amount: NaN
is: C01342
constant: false
has only substance units: false
name: Ammonium
initial concentration: 1.0
is: HMDB00051

metaM HC01842 c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:31997
is: SBO:0000247
name: Phosphodimethylethanolamine
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM utp n
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: UTP(4-)
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: CHEBI:46398
initial amount: NaN
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110029#_ca9c252c_5ce1_4139_bffa_ceaa70df7a70
is encoded by: hsa:1120
is: Q9Y259
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: CHKB
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_5b77f121_03cc_45f7_b13d_24def3b5bf28
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA081045
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: _AA081045_1_c

metaM HC02205 e
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
initial concentration: 1.0
type: Species
name: prostaglandin-b2
has only substance units: false
is: CHEBI:28099

metaR RETFA
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110029#
type: Reaction
reversible: false
kinetic law: MODEL1310110029#
name: retinol acyltransferase

metaR SERLYSNaex
kinetic law: MODEL1310110029#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: Serine/Lysine Na-dependent exchange (Ser in)
fast: false
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
reversible: false

metaM idp e
is: SBO:0000247
constant: false
has only substance units: false
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
initial concentration: 1.0
is: CHEBI:58280
is: HMDB03335
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_bb3c01f1_d6fc_4eac_9cf8_251ada320acd
boundary condition: true
constant: false
is: SBO:0000252
name: ALDH3A1
is: P30838
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:218
has only substance units: false

metaR CYTK9
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
reversible: true
is described by: ECO:0000269

metaM ump n
constant: false
is: SBO:0000247
is: HMDB00288
initial concentration: 1.0
is: CHEBI:57865
initial amount: NaN
boundary condition: false
name: UMP(2-)
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR SERtN1
reactant: MODEL1310110029#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110029#
modifier: MODEL1310110029#
name: Serine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110029#_2f3e0e7f_1e9d_4d48_a7da_8cf063431f93
boundary condition: true
is: SBO:0000252
name: CPT1B
type: Species
is encoded by: hsa:1375
is: B7Z5T8
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaM nh4 n
is: HMDB00051
is: SBO:0000247
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28938
initial concentration: 1.0
name: ammonium
boundary condition: false

metaR r0944
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
reversible: true

metaR PROt4 2 r
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
name: Proline transport (sodium symport) (2:1)
is described by: ECO:0000006
type: Reaction
product: MODEL1310110029#

metaR OCTAt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
is: SBO:0000185
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Octanoate transport via diffusion

metaR CYTK1
reactant: MODEL1310110029#
fast: false
reversible: true
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: cytidylate kinase (CMP)
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0480
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_0de7dc44_908e_41a7_b000_eb363377f324
name: CCBL1
is encoded by: hsa:883
is: SBO:0000252
is: Q16773
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR NICRNS
name: NICRNS
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
kinetic law: MODEL1310110029#
reversible: false
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_1caf9171_f870_4774_b4f2_60e37b5b67df
is encoded by: hsa:341947
initial concentration: NaN
is: Q7Z4L0
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: COX8C
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e36042bd_ea57_4c30_8b07_64dceca2a868
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is: P09923
initial amount: NaN
is encoded by: hsa:248
name: ALPI
has only substance units: false

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR MCLOR
fast: false
name: 3-Mercaptolactate:NAD+ oxidoreductase
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
reversible: true
product: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27

metaM k e
is: C00238
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: potassium
type: Species
is: CHEBI:29103
has only substance units: false
boundary condition: false
constant: false
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaR MCITS
reversible: false
reactant: MODEL1310110029#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
type: Reaction
name: 2-methylcitrate synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
product: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_15ad133b_871b_4d92_98f8_d0707fe16d5c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7296
is: Q16881
is: SBO:0000252
name: TXNRD1
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_5e975177_8acb_4f71_98f2_e7ffe58e247a
is: P18405
is: SBO:0000252
is encoded by: hsa:6715
constant: false
boundary condition: true
name: SRD5A1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0f1dbe8b_1268_4713_b760_de68490e22f5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: AACS
is: Q86V21
is encoded by: hsa:65985

http://identifiers.org/biomodels.db/MODEL1310110029#_76081415_6f52_47bc_9ebd_8d2e5c2806ed
name: NME1:NME2
constant: false
boundary condition: true
type: Species
is: SBO:0000297
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4830
initial amount: NaN

metaM Rtotal e
is: C00255
type: Species
initial concentration: 1.0
initial amount: NaN
name: R total
boundary condition: false
is: SBO:0000247
is: CHEBI:3554
constant: false
has only substance units: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: HMDB00244

metaM pmtcrn r
initial concentration: 1.0
boundary condition: false
name: L-palmitoylcarnitine
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17490
is: HMDB00222
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR FUMtm
fast: false
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is: SBO:0000185
product: MODEL1310110029#

metaM ppcoa c
is: HMDB01275
boundary condition: false
name: Propanoyl-CoA
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
is: C00100
has only substance units: false

metaR CYTK2
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_7c6ff546_b84e_4dcb_9f5e_a3b1e4222d5f
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ACSS3
is: SBO:0000252
is: Q9H6R3
is encoded by: hsa:79611
constant: false

metaR PIt8
is: SBO:0000185
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
kinetic law: MODEL1310110029#
type: Reaction
name: phosphate transport in/out via Na+ symporter
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000006
fast: false
reversible: true
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_406df792_c06b_45bc_959c_45179c5140e2
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI640625_1_c
constant: false
boundary condition: true
is encoded by: hsa:AI640625

http://identifiers.org/biomodels.db/MODEL1310110029#_21f00fda_4bd5_4cf0_8a31_b5740993e2a1
name: _R33828_1_c
constant: false
initial concentration: NaN
is encoded by: hsa:R33828
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_0909e599_a228_4dea_bbbe_09db3375f9c0
is: SBO:0000252
type: Species
is: Q8TF71
name: SLC16A10
is encoded by: hsa:117247
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM idp c
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
type: Species
boundary condition: false
name: IDP(3-)
initial concentration: 1.0
constant: false
is: CHEBI:58280
is: HMDB03335
is: SBO:0000247

metaR THFtm
kinetic law: MODEL1310110029#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01117
is: CHEBI:59458
initial amount: NaN
is: C04352
initial concentration: 1.0
constant: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
boundary condition: false

metaM nadh c
name: Nicotinamide adenine dinucleotide - reduced
constant: false
is: CHEBI:57945
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00004
is: HMDB01487
is: SBO:0000247

metaR RTOTALt
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
reversible: true
product: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR ADSK
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.25
name: adenylyl-sulfate kinase
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:

metaR r1746
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110029#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110029#
reactant: MODEL1310110029#

metaR r2360
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction

metaR PIt7
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185

metaR CYTK3
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_207350de_2fa4_42c4_ac35_60e1b5cd21f1
has only substance units: false
constant: false
is: Q6ZMU0
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:210
is: SBO:0000252
initial amount: NaN
name: ALAD

http://identifiers.org/biomodels.db/MODEL1310110029#_c697d1f2_adaa_4c26_b8bd_897e8925deb8
is: SBO:0000252
boundary condition: true
name: NDUFB8
constant: false
is encoded by: hsa:4714
type: Species
initial concentration: NaN
initial amount: NaN
is: O95169
has only substance units: false

metaM pe hs e
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
boundary condition: false
name: phosphatidylethanolamine
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_3341bdfa_71dc_4e12_b607_dabb85135e30
name: _AA854479_1_m
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA854479
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_98d5cc82_ca1a_4d80_8e7b_4d41fd3aa2d0
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:6528
name: SLC5A5
is: Q92911

metaR r0946
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR MAN1PT2
is version of: http://identifiers.org/ec-code/2.7.7.13
name: mannose-1-phosphate guanylyltransferase (GDP)
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#

metaM glyclt x
boundary condition: false
is: CHEBI:29805
initial amount: NaN
type: Species
constant: false
name: glycolate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00115
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160

metaM h m
type: Species
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
has only substance units: false
is: C00080
is: CHEBI:24636
name: proton
initial concentration: 1.0

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
initial concentration: 1.0
is: CHEBI:57566
initial amount: NaN
type: Species
name: dCMP(2-)
is: HMDB01202
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR MTHGXLt
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Methylglyoxal transport (cytosol to extracellular)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
product: MODEL1310110029#

metaM Rtotal c
type: Species
initial concentration: 1.0
name: R total
boundary condition: false
initial amount: NaN
is: CHEBI:16349
has only substance units: false
is: HMDB00904
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false

metaR r2361
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
name: inorganic diphosphatase
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110029#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0c6221d9_29fd_4ec0_8603_85a6548abaa6
initial amount: NaN
is encoded by: hsa:4952
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: OCRL
constant: false
is: Q01968
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_324ed95c_1cfa_4e1c_9c1d_4b0393745a5e
type: Species
is encoded by: hsa:4712
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: NDUFB6
is: O95139

metaR CERT2rt
name: ceramide transport protein
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
reversible: true
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_c503361a_edd6_42a6_8263_e3463ba7715e
boundary condition: true
has only substance units: false
is: P19440
is encoded by: hsa:2678
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: GGT1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_849d1add_b255_4b10_9f23_46fa76170a6f
boundary condition: true
has only substance units: false
is: P40926
type: Species
is encoded by: hsa:4191
name: MDH2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

metaR TAGt
reversible: true
type: Reaction
fast: false
name: triacylglycerol transport
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185

metaM ppp9 m
is: HMDB00241
has only substance units: false
type: Species
name: Protoporphyrin
initial concentration: 1.0
constant: false
is: CHEBI:36159
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191

http://identifiers.org/biomodels.db/MODEL1310110029#_1d8db210_2ad2_430b_ae9e_834048095066
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: CMA1
is: Q4FEB3
initial concentration: NaN
is encoded by: hsa:1215

http://identifiers.org/biomodels.db/MODEL1310110029#_062ba823_c0c7_4d54_a19f_003130e1776b
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:6509
initial amount: NaN
has only substance units: false
is: P43007
boundary condition: true
name: SLC1A4

http://identifiers.org/biomodels.db/MODEL1310110029#_677b8b67_ad54_47f3_8d0c_e6fdb916f29a
name: PIPOX
initial amount: NaN
boundary condition: true
is encoded by: hsa:51268
is: Q9P0Z9
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaR GLYt7 211 r
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110029#
type: Reaction
reversible: true
modifier: MODEL1310110029#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
reactant: MODEL1310110029#

metaR CO2tp
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
name: CO2 peroxisomal transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110029#_2d29aeae_4900_4f1c_af3b_f9bc4df53397
is encoded by: hsa:AA278423
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA278423_1_m

metaM CE0713 m
has only substance units: false
is: HMDB02329
is: SBO:0000247
constant: false
name: 3-oxolinoleoyl-CoA
type: Species
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM HC01444 e
initial amount: NaN
boundary condition: false
type: Species
name: Galactosylglycerol
is: CHEBI:15754
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a231e52b_9b05_49bc_b05d_6c44f9e9974a
name: _AA532636_1_m
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA532636
type: Species
boundary condition: true
is: SBO:0000252

metaM gly e
is: C00037
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:3339
is: HMDB00123
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
name: Glycine

http://identifiers.org/biomodels.db/MODEL1310110029#_41da7849_8e0d_4ac0_9d86_99985512e4db
name: PLA2G3
type: Species
is encoded by: hsa:50487
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9NZ20
is: SBO:0000252
constant: false
has only substance units: false

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
initial amount: NaN
constant: false
is: CHEBI:57865
is: HMDB00288
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_5b035cf9_b0a1_40d1_a973_6bd21c5b7536
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: GBA
initial amount: NaN
is: B7Z5G2
has only substance units: false
is encoded by: hsa:2629

metaR EX gdp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GDP exchange
type: Reaction

metaR r1643
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1857
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_3ad671ed_82b0_418d_81c5_97b129f89c85
initial amount: NaN
is encoded by: hsa:4724
name: NDUFS4
is: SBO:0000252
constant: false
has only substance units: false
is: O43181
boundary condition: true
initial concentration: NaN
type: Species

metaM nh4 c
is: CHEBI:28938
is: C01342
constant: false
boundary condition: false
is: SBO:0000247
name: Ammonium
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00051

metaR STRDNCt
fast: false
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110029#_a822bb05_81fb_4a51_bebd_b8af8ed643ba
is encoded by: hsa:10637
has only substance units: false
type: Species
boundary condition: true
name: LEFTY1
initial amount: NaN
constant: false
initial concentration: NaN
is: O75610
is: SBO:0000252

metaM tsul m
constant: false
is: CHEBI:16094
type: Species
is: HMDB00257
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)

metaR PPCDC
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
type: Reaction
reactant: MODEL1310110029#
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:

metaR r0881
fast: false
name: Active transport
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#

metaR r1644
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_763d8668_f7fb_4647_9879_ea14fc49092f
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4720
is: B7Z792
name: NDUFS2
type: Species
initial amount: NaN

metaR PSSA1 hs
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
fast: false
name: Phosphatidylserine synthase homo sapiens
kinetic law: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.8.29

metaR GALt4
product: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
name: galactose transport via sodium symport
kinetic law: MODEL1310110029#
is described by: ECO:0000269

metaM betald m
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
is: CHEBI:15710
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: betaine aldehyde
initial concentration: 1.0
is: HMDB01252
boundary condition: false

metaR r2403
kinetic law: MODEL1310110029#
reversible: false
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_36210b91_3f0e_4e70_9e87_5748d1fa563f
boundary condition: true
is encoded by: hsa:4540
is: P03915
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: ND5
initial amount: NaN

metaM udpg c
constant: false
is: CHEBI:58367
type: Species
name: UDPglucose
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00029
has only substance units: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286

metaR BILIRED
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110029#
name: Nad(p)h biliverdin reductase
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.24
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_784d4362_e2bc_4763_8fe4_5085739adfc6
is: SBO:0000252
constant: false
name: ACADM
boundary condition: true
initial amount: NaN
is: P11310
is encoded by: hsa:34
has only substance units: false
type: Species
initial concentration: NaN

metaR NADPtru
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

metaR RE1342C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is: SBO:0000176
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: RE1342

http://identifiers.org/biomodels.db/MODEL1310110029#_a94ab210_dcb8_4379_ba00_820df85606da
is encoded by: hsa:81539
is: Q9H2H9
has only substance units: false
initial concentration: NaN
type: Species
name: SLC38A1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR r2145
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110029#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM 3hpcoa m
type: Species
is: HMDB06807
boundary condition: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial concentration: 1.0
constant: false
name: 3-hydroxypropanoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:58528

http://identifiers.org/biomodels.db/MODEL1310110029#_1a47b410_f3dd_422d_9725_15d664c0dd60
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI935189
boundary condition: true
type: Species
is: SBO:0000252
name: _AI935189_1_m
has only substance units: false
constant: false

metaM itacon m
name: itaconate(2-)
type: Species
initial concentration: 1.0
is: HMDB02092
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: CHEBI:17240
initial amount: NaN
boundary condition: false

metaM ump e
initial amount: NaN
constant: false
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false
is: HMDB00288
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
name: UMP(2-)

metaR CYTK4n
reactant: MODEL1310110029#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_063345b9_9d95_47d2_920b_9797f513bd86
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2747
initial concentration: NaN
is: P49448
name: GLUD2

metaR r2406
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaM g6p c
is: SBO:0000247
initial concentration: 1.0
is: HMDB01401
is: CHEBI:61548
constant: false
has only substance units: false
boundary condition: false
is: C00092
name: D-Glucose 6-phosphate
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial amount: NaN

metaR AMETtd
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
is described by: ECO:0000134
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaR r1641
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CO2tm
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
type: Reaction
name: CO2 transport (diffusion), mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF

http://identifiers.org/biomodels.db/MODEL1310110029#_83419ed5_fd5f_4281_a353_8cee1fab066c
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: LDHB
is: P07195
is encoded by: hsa:3945

metaM hista c
is: HMDB00870
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false
is: SBO:0000247
name: histamium
type: Species
is: CHEBI:58432

metaM nh4 e
constant: false
is: SBO:0000247
name: ammonium
boundary condition: false
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
initial concentration: 1.0
is: HMDB00051
has only substance units: false
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110029#_2c22d0c7_471c_4ffd_b766_144e4f26e602
name: CTPS2
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NRF8
constant: false
has only substance units: false
is encoded by: hsa:56474
initial amount: NaN
initial concentration: NaN

metaR r2144
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true

metaR MALSO3tm
is: SBO:0000185
type: Reaction
reversible: true
name: Malate:sulfite antiport, mitochondrial
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110029#_da9e877e_0796_4968_914e_cf4d7decad41
has only substance units: false
is: SBO:0000252
is: Q549M5
name: NDUFC2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4718
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_35e31a97_5e83_4d58_89b0_f50061ca9140
initial concentration: NaN
name: PLCL1
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5334
is: Q15111
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_5c6e0a5c_d387_4667_8b79_30ef21a78878
boundary condition: true
constant: false
type: Species
is encoded by: hsa:R51273
name: _R51273_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1642
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM nmn c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:14649
name: NMN
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
is: C00455
is: HMDB00229
type: Species

metaR r2405
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ce41db48_49a2_40be_bfcf_f556f032336e
name: SLC6A12
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P48065
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6539
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_818de7b9_d725_4d90_ace0_b5cf7c89e59f
is: O43820
constant: false
is encoded by: hsa:8372
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: HYAL3
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_bf2bebce_7f8a_46bd_a9b5_d8d7ccdf5e5f
boundary condition: true
is encoded by: hsa:7360
is: SBO:0000252
constant: false
name: UGP2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaM maltttr e
boundary condition: false
is: C02052
name: Maltotetraose
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296

http://identifiers.org/biomodels.db/MODEL1310110029#_31129058_828a_45c5_8f0f_3818bcf574c9
name: SLC7A8:SLC3A2
boundary condition: true
has part: Q9UHI5
is encoded by: hsa:23428
constant: false
is: SBO:0000297
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM ump c
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57865
name: UMP
initial amount: NaN
is: C00105
is: HMDB00288
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM hista e
type: Species
name: histamium
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00870
initial concentration: 1.0
constant: false
is: CHEBI:58432
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

metaR ASNtN1
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_36b76e19_bde5_401e_9258_c057c7b82733
is encoded by: hsa:6536
constant: false
has only substance units: false
type: Species
boundary condition: true
name: SLC6A9
is: SBO:0000252
initial concentration: NaN
is: B7Z3W8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_1d3441de_bb90_4662_a485_072d3f779d7e
type: Species
is: P21399
constant: false
initial amount: NaN
initial concentration: NaN
name: ACO1
boundary condition: true
is encoded by: hsa:48
is: SBO:0000252
has only substance units: false

metaR ETHAK
is described by: ECO:0000269
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
name: Ethanolamine kinase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.82
fast: false

metaM HC00900 c
name: Methylmalonate
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM nicrns c
is: HMDB06809
name: Nicotinate D-ribonucleoside
has only substance units: false
constant: false
is: CHEBI:58527
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
initial amount: NaN

metaR GCHOLAt2
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
reversible: false
name: glycocholate transport via sodium cotransport
fast: false
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_56803491_9091_4cca_8ee4_bc1af0aff914
is: P49189
has only substance units: false
is encoded by: hsa:223
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH9A1
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_4aeaddf1_f2ac_444f_a066_339de300f884
boundary condition: true
is encoded by: hsa:10965
name: ACOT2
has only substance units: false
is: P49753
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR LTD4DP
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaM trdrd c
is: C00342
initial concentration: 1.0
is: CHEBI:15967
has only substance units: false
initial amount: NaN
name: Reduced thioredoxin
constant: false
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
type: Species

metaR r2142
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110029#

metaR r0672
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
reactant: MODEL1310110029#
fast: false
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaR RE1522M
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
name: RE1522
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_61d9be84_26e7_41d5_895e_a758cb76664a
initial amount: NaN
boundary condition: true
is: P28330
name: ACADL
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:33

http://identifiers.org/biomodels.db/MODEL1310110029#_ebe2bd4b_57f5_49b4_a79b_5adf1553eaf3
name: UROS
initial concentration: NaN
has only substance units: false
is: P10746
type: Species
is encoded by: hsa:7390
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM 56dura c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0
has only substance units: false
name: 5,6-dihydrouracil
is: CHEBI:15901
initial amount: NaN
is: HMDB00076
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_64446a0d_26af_4261_a068_19c0e2a8b09a
is encoded by: hsa:54407
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q96QD8
type: Species
initial amount: NaN
name: SLC38A2
constant: false
has only substance units: false

metaR r1640
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110029#

metaR SERGLYexR
type: Reaction
is described by: ECO:0000304
reversible: true
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_ef9c82e8_92ab_4793_ab9e_5990d2e42707
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6568
initial amount: NaN
initial concentration: NaN
name: SLC17A1
type: Species
is: Q14916
boundary condition: true

metaR URAt
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000269

metaM HC01672 c
has only substance units: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
boundary condition: false
type: Species
name: Acetyl adenylate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37666
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f9a64f4b_7ed4_4cf2_97e0_a97030523ab7
type: Species
has only substance units: false
name: _NM_013421_1_e
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:NM 013421
boundary condition: true

metaM gly c
is: SBO:0000247
has only substance units: false
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
is: CHEBI:3339
type: Species
name: Glycine
is: HMDB00123
initial amount: NaN
initial concentration: 1.0
constant: false

metaR 3HKYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
modifier: MODEL1310110029#
type: Reaction
reversible: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

metaM h c
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: proton

metaR r0377
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#

metaR PAPtg
is: SBO:0000185
product: MODEL1310110029#
name: adenosine 3',5'-bisphosphate Golgi transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
reversible: false

metaM prostgi2 c
boundary condition: false
is: HMDB01335
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
has only substance units: false
name: prostaglandin I2(1-)
is: CHEBI:57403
constant: false
initial concentration: 1.0

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM pe hs m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:16038
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

metaR r2473
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reactant: MODEL1310110029#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.4.5
reversible: false
type: Reaction

metaR r2141
modifier: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true

metaR DHCR242r
fast: false
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
name: 24-dehydrocholesterol reductase [Precursor]
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000134
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR RE2660C
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110029#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
name: RE2660
is described by: ECO:0000000

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM ppcoa m
type: Species
boundary condition: false
name: Propanoyl-CoA
is: HMDB01275
is: CHEBI:57392
initial concentration: 1.0
is: C00100
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
constant: false
initial amount: NaN

metaR URIDK2m
product: MODEL1310110029#
is described by: ECO:0000134
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
kinetic law: MODEL1310110029#
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_1c7c5c9a_8679_4f2d_bf89_53d42d876fa5
is: O43488
constant: false
boundary condition: true
name: AKR7A2
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8574

metaM nadh m
initial amount: NaN
boundary condition: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
is: C00004
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
constant: false

metaR TYRCBOX
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
name: L-Tyrosine carboxy-lyase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_4d4289d4_a664_4128_b24d_d4658497bfa9
name: HMOX1
is: Q6FH11
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3162
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR r0670
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
reactant: MODEL1310110029#
reversible: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_e1703b5c_28d2_467c_8c27_e750362830f3
type: Species
constant: false
is encoded by: hsa:9023
name: CH25H
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O95992

metaR r2140
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_bd0db411_437a_4ad9_9320_51423fd68f21
constant: false
is encoded by: hsa:7296
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: TXNRD1
type: Species
initial concentration: NaN
has only substance units: false

metaR R group phosphotase 3
product: MODEL1310110029#
reversible: false
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
name: R group phosphotase 3
reactant: MODEL1310110029#
is described by: ECO:0000000

metaM 1pyr5c m
type: Species
boundary condition: false
name: 1-Pyrroline-5-carboxylate
initial amount: NaN
is: CHEBI:15893
is: SBO:0000247
is: HMDB01301
initial concentration: 1.0
is: C03912
constant: false
has only substance units: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912

http://identifiers.org/biomodels.db/MODEL1310110029#_4f6020df_1fca_4d2b_aaec_3899734f34c9
name: GOT1
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2805
is: P17174
constant: false

metaM HC02179 c
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM C05965 e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB04243
is: CHEBI:57444
initial amount: NaN
name: 12(S)-HPETE(1-)

http://identifiers.org/biomodels.db/MODEL1310110029#_822b7b13_5cd0_4fd0_af07_7ec823e84c23
boundary condition: true
is: Q9BQG2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:83594
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: NUDT12

http://identifiers.org/biomodels.db/MODEL1310110029#_b636e941_08d6_4fb5_8de8_9775bfa06e6b
is: Q9NWU1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:54995
name: OXSM

metaR GLCter
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
product: MODEL1310110029#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_f77b5ab0_4a2d_4625_a20c_7944e4f0b13c
initial amount: NaN
initial concentration: NaN
is: Q9UM01
is encoded by: hsa:9056
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC7A7
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e6164456_0ef3_4931_b0e7_4e8473c47373
is encoded by: hsa:6240
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P23921
type: Species
initial amount: NaN
name: RRM1

http://identifiers.org/biomodels.db/MODEL1310110029#_eea27a6b_bfb8_47c4_b7dd_8c841f8bd505
boundary condition: true
is: P21399
name: ACO1
constant: false
initial concentration: NaN
is encoded by: hsa:48
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR R group phosphotase 2
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
name: R group phosphotase 2
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110029#

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM retinol cis 11 e
constant: false
is: HMDB06216
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16302
name: 11-cis-retinol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_cb452d17_a173_48c1_823e_b44e8534f27a
initial concentration: NaN
is encoded by: hsa:1892
is: P30084
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ECHS1

metaM pd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Previtamin D3
type: Species
is: HMDB06500
initial amount: NaN

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_00cbe2d7_f67b_4c90_b857_d51be88ac362
has only substance units: false
is: F5H066
initial amount: NaN
boundary condition: true
is encoded by: hsa:6560
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: SLC12A4

metaM 4hphac e
type: Species
name: 4-hydroxyphenylacetate
boundary condition: false
is: HMDB00020
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
initial amount: NaN
is: SBO:0000247

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r1639
fast: false
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185

metaM no e
initial concentration: 1.0
name: Nitric oxide
constant: false
type: Species
has only substance units: false
is: C00533
is: SBO:0000247
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
is: HMDB03378
initial amount: NaN

MODEL1310110029
species: metaM xylu L c
species: metaM dhcholestanate c
reaction: metaR r0580
species: metaM gthox c
species: metaM lac D c
species: metaM his L e
reaction: metaR r2376
notes: Thiele2013 - Ovary ovarian stroma cells The model of ovary ovarian stroma cells metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is described in the article: A community-driven global reconstruction of human metabolism. Thiele I, et al . Nature Biotechnology Abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. This model is hosted on BioModels Database and identified by: MODEL1310110029 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
reaction: metaR r1604
reaction: metaR RE1898C
reaction: metaR r2331
reaction: metaR r0829
species: metaM mag hs c
reaction: metaR r0974
reaction: metaR VITD3t2
reaction: metaR CDS
reaction: metaR FRDPtc
reaction: metaR EX ttdca LPAREN e RPAREN
species: metaM leuktrC4 e
species: metaM gthox m
reaction: metaR IDPtn
reaction: metaR RE2677G
species: metaM 5mthf e
reaction: metaR r2095
reaction: metaR FACOAL204
species: metaM mi14p c
species: metaM sphgn c
reaction: metaR r1549
reaction: metaR RETI2
species: metaM 3hpp m
reaction: metaR r2327
reaction: metaR r2102
reaction: metaR CERT1rt
reaction: metaR ADK3
reaction: metaR r0994
reaction: metaR LNLCCPT1
species: metaM 3hbcoa m
species: metaM HC02214 e
reaction: metaR 3HBCOAHLm
reaction: metaR CBR2
species: metaM HC02179 e
species: metaM co c
species: metaM HC00591 m
species: metaM c4crn c
reaction: metaR r2347
reaction: metaR LGTHL
reaction: metaR EX 13 cis retnglc LPAREN e RPAREN
species: metaM digalside hs g
reaction: metaR r2132
reaction: metaR UPPN
reaction: metaR r1453
reaction: metaR r0522
reaction: metaR r1646
species: metaM oaa m
species: metaM odecoa c
reaction: metaR EX HC01610 LPAREN e RPAREN
reaction: metaR RE2649C
reaction: metaR r0084
species: metaM prostgi2 e
species: metaM ru5p D r
species: metaM 5thf e
reaction: metaR ACHEe
reaction: metaR CREATt4 2 r
reaction: metaR r0834
species: metaM coa r
reaction: metaR NH4tn
reaction: metaR RE1897C
reaction: metaR r2497
species: metaM arachd l
reaction: metaR MI13PP
reaction: metaR XOL27OHtm
species: metaM HC00342 m
reaction: metaR r0400
reaction: metaR HACD1m
species: metaM dutp n
reaction: metaR DRPA
reaction: metaR r2085
species: metaM ac c
reaction: metaR DGAT
species: metaM amp c

metaR DESAT18 3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.14.19.1
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_adcc61f0_f9ac_4089_8bd7_752fed49236b
boundary condition: true
is: G3XA95
name: PPAP2A
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8611

metaR R group phosphotase 1
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: R group phosphotase 1
reversible: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9820f9b3_91f1_4b40_8dee_39d0f0b07d92
boundary condition: true
has only substance units: false
type: Species
is: Q9BYZ2
name: LDHAL6B
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:92483

http://identifiers.org/biomodels.db/MODEL1310110029#_5c8369dc_44f9_4531_b226_691228304477
boundary condition: true
is encoded by: hsa:9058
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: SLC13A2
is: E7ETH5

metaM maltpt e
boundary condition: false
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
constant: false
is: C02052
is: http://identifiers.org/pubchem.compound/5141
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01296

http://identifiers.org/biomodels.db/MODEL1310110029#_70434177_7f39_4035_9205_8de9cb7489ee
name: ATP2B1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:490
is: P20020
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM lnlc r
boundary condition: false
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: CHEBI:30245
is: HMDB00673
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR r1638
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR r0517
fast: false
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110029#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM 3mox4hoxm c
is: SBO:0000247
type: Species
name: 3-Methoxy-4-hydroxymandelate
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: HMDB00291
boundary condition: false
is: CHEBI:27622
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM pmtcrn c
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: L-palmitoylcarnitine
initial concentration: 1.0
is: HMDB00222
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2721c9a5_2fb3_453a_91ec_46a4f7226c48
initial amount: NaN
type: Species
name: GPI
boundary condition: true
is encoded by: hsa:2821
is: P06744
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM 2mop m
is: SBO:0000247
boundary condition: false
name: 2-methyl-3-oxopropanoate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57700
is: HMDB01172
constant: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR r0669
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reactant: MODEL1310110029#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110029#

metaM 20ahchsterol m
is: HMDB06283
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
initial concentration: 1.0
is: CHEBI:1296
is: SBO:0000247
name: 20-hydroxycholesterol
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM retinol cis 11 c
constant: false
is: HMDB06216
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16302
has only substance units: false
name: 11-cis-retinol

metaR r1637
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9bfd249e_f5fd_46a8_a8e8_72a23b6a1081
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: NDUFA7
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6FG42
is encoded by: hsa:4701

metaM no c
is: HMDB03378
has only substance units: false
initial concentration: 1.0
name: Nitric oxide
initial amount: NaN
type: Species
constant: false
is: C00533
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
is: CHEBI:16480

http://identifiers.org/biomodels.db/MODEL1310110029#_07ecd033_a7be_4e47_afa8_58099fea7813
boundary condition: true
is: P11908
initial amount: NaN
is encoded by: hsa:5634
constant: false
type: Species
name: PRPS2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR O2Stx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110029#
reversible: true
is: SBO:0000185
name: superoxide anion transport via diffusion (peroxisome)
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_de676690_c819_44ef_891f_8d5136943f53
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q96C36
name: PYCR2
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:29920
initial amount: NaN

metaM C02470 c
boundary condition: false
name: Xanthurenic acid
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5485
is: C02470
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00881
constant: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470

metaM pap g
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
has only substance units: false
is: CHEBI:58343
constant: false
type: Species
is: SBO:0000247
is: HMDB00061
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110029#_c9ec29ac_0939_4ac8_9a03_f55215ddaa09
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P55017
is encoded by: hsa:6559
name: SLC12A3
initial concentration: NaN
has only substance units: false
constant: false

metaR r1636
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5d1acab8_deb3_436b_add9_85540b74ebd9
type: Species
is encoded by: hsa:AV713053
name: _AV713053_1_m
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0156
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
modifier: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is described by: ECO:0000000

metaR r2040
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
reversible: false
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_7b3dafac_9bc2_41d1_a696_caae9f1132ab
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:124
constant: false
name: ADH1A:ADH1B
has part: P07327
has only substance units: false
is: SBO:0000297

metaR r0668
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110029#

metaM ala B c
constant: false
is: HMDB00056
is: CHEBI:16958
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_b93b3e96_1fde_43bc_9cfa_072cec599a57
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P05062
is encoded by: hsa:229
name: ALDOB
boundary condition: true
initial amount: NaN
constant: false

metaR DHPR2
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000304
kinetic law: MODEL1310110029#
reversible: false
name: 6,7-dihydropteridine reduction
fast: false
type: Reaction

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR BTNt2
is: SBO:0000185
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110029#
name: Biotin reversible transport via proton symport
is described by: ECO:0000269
reversible: true

metaM C04849 e
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_86d535d5_cd5a_4508_ba10_a8254f16b61e
has only substance units: false
is encoded by: hsa:2936
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P00390
constant: false
name: GSR
initial concentration: NaN
type: Species

metaR PAPStg
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
product: MODEL1310110029#
name: 3'-Phosphoadenylyl sufate Golgi transport

metaM HC01376 m
constant: false
boundary condition: false
is: CHEBI:28692
has only substance units: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
name: S-(2-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_78ed3ca6_174c_40c1_9e5a_f6a4a422991c
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q16795
constant: false
is encoded by: hsa:4704
type: Species
name: NDUFA9
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_3fb8bd55_f6f2_4c59_a850_6dcb9f19a674
is: B3KXN9
constant: false
is encoded by: hsa:84890
name: ADO
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r1635
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_84c45c3d_cc03_4103_8959_77f0ad274e81
boundary condition: true
has only substance units: false
name: NDUFS6
type: Species
initial concentration: NaN
is: Q6IBC4
is: SBO:0000252
is encoded by: hsa:4726
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_90105f57_caac_4bb5_b758_7dbc0649ff22
boundary condition: true
is: SBO:0000252
constant: false
is: D3DX95
is encoded by: hsa:1103
initial amount: NaN
type: Species
name: CHAT
has only substance units: false
initial concentration: NaN

metaR r1978
fast: false
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#

metaM dcyt c
is: CHEBI:15698
constant: false
is: HMDB00014
initial concentration: 1.0
initial amount: NaN
type: Species
name: Deoxycytidine
boundary condition: false
is: C00881
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
has only substance units: false

metaR r0157
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/6.3.4.2
fast: false
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_569da7cb_0213_4bfb_9d82_c0969fa3ac09
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
is: SBO:0000252
is: Q9UHI7

metaM utp c
initial amount: NaN
is: C00075
type: Species
is: HMDB00285
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: CHEBI:46398
name: UTP
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9666fd71_4326_4770_a764_bcfb0d24c78b
initial amount: NaN
name: TKTL1
is encoded by: hsa:8277
type: Species
is: SBO:0000252
constant: false
is: B7Z7I0
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR ATPtm
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
name: ADP/ATP transporter, mitochondrial
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110029#

metaR ALA DASH DTDe
reactant: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES:no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
fast: false
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110029#
name: exit of D-alanine from the enterocytes
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_f0ba0e03_ac2a_4e41_9902_ee9b0799d578
type: Species
is encoded by: hsa:80270
is: Q9H2F3
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: HSD3B7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a317c17e_98fe_4da4_a1a7_5c9a87a7be52
initial amount: NaN
is: Q5JPA4
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLCO1C1
constant: false
initial concentration: NaN
is encoded by: hsa:53919

metaM ncam c
is: C00153
has only substance units: false
is: CHEBI:0
is: SBO:0000247
type: Species
is: HMDB01406
boundary condition: false
notes: FORMULA: C6H6N2O CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: Nicotinamide
constant: false

metaM datp c
has only substance units: false
name: dATP
constant: false
is: CHEBI:61404
boundary condition: false
initial amount: NaN
is: HMDB01532
is: C00131
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_c2aa1a33_f858_4676_accb_268fd2a916ad
initial concentration: NaN
type: Species
is encoded by: hsa:60482
initial amount: NaN
name: SLC5A7
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9GZV3
constant: false

metaM co2 x
is: CHEBI:16526
is: HMDB01967
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: carbon dioxide
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_99ea8dd2_af4c_4175_8973_b5cb3958c8c7
is encoded by: hsa:80347
is: Q13057
initial concentration: NaN
constant: false
type: Species
name: COASY
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_741910fd_5c41_4dba_9f32_57f8082ac2f4
is: SBO:0000252
type: Species
name: RHAG
is: Q96E98
boundary condition: true
constant: false
is encoded by: hsa:6005
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM succoa m
constant: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57292
is: HMDB01022
name: Succinyl-CoA
type: Species
has only substance units: false

metaR r1172
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
product: MODEL1310110029#
is: SBO:0000176
type: Reaction
name: EC:3.1.1.13
kinetic law: MODEL1310110029#
fast: false

metaR r1634
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR HISTAtu
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110029#
reversible: true
fast: false
is: SBO:0000185
name: Histamine uniport
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM ala B e
initial concentration: 1.0
constant: false
is: HMDB00056
is: CHEBI:16958
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine

metaR NDPK5n
fast: false
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_5e231383_9666_4edd_9bdb_9fc9651dfa0b
is: SBO:0000252
is encoded by: hsa:23236
name: PLCB1
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_21f625e7_fe6e_4bce_8713_ec28a4647448
name: OGDHL
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9ULD0
type: Species
constant: false
is encoded by: hsa:55753

metaR O2St
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
reactant: MODEL1310110029#
fast: false

metaR LAPCOAe
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
name: LAPCOAe
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
fast: false

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110029#
is: SBO:0000176
name: Choline O-acetyltransferase
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269

metaM HC01409 m
initial amount: NaN
is: CHEBI:27540
name: Hexanoyl-CoA
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_617e65d1_943e_458b_afbb_c28afb834dc4
initial amount: NaN
name: SLC16A1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6566
is: B4DKS0
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR ARGtm
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: arginine mitochondrial transport via ornithine carrier
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
reversible: true

metaR KCCt
is described by: ECO:0000269
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
name: K+-Cl- cotransport
reversible: true
fast: false

metaR r1633
reactant: MODEL1310110029#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM L2aadp6sa c
name: L-allysine
initial concentration: 1.0
is: CHEBI:17917
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: HMDB01263
initial amount: NaN
constant: false
has only substance units: false

metaM thf m
is: CHEBI:57453
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: C00101
is: SBO:0000247
type: Species
is: HMDB01846
boundary condition: false
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM HC01603 c
is: SBO:0000247
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
initial amount: NaN
constant: false

metaM pap c
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00061
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaM 4hphac c
initial amount: NaN
is: CHEBI:48999
name: 4-hydroxyphenylacetate
type: Species
initial concentration: 1.0
constant: false
is: HMDB00020
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: SBO:0000247
boundary condition: false

metaM bildglcur e
type: Species
constant: false
is: CHEBI:58471
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false
boundary condition: false

metaM pail45p hs n
type: Species
is: CHEBI:28910
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
initial concentration: 1.0

metaM dcmp c
is: HMDB01202
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: dCMP
is: C00239
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: CHEBI:57566
boundary condition: false

metaM inost c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
is: HMDB00211
boundary condition: false
is: CHEBI:17268
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: myo-inositol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_9dfa7e41_526a_489d_9c04_0963fff4cadb
has part: O75489
has part: O43678
is encoded by: hsa:126328
is encoded by: hsa:4715
has part: Q7GXY9
has part: Q7GXZ4
is encoded by: hsa:4700
has only substance units: false
initial amount: NaN
is encoded by: hsa:4696
is encoded by: hsa:4731
has part: Q6IBC4
is encoded by: hsa:4698
is encoded by: hsa:4537
is encoded by: hsa:4710
has part: Q9Y6M9
is: SBO:0000297
has part: Q6IBB5
has part: O43674
has part: O00483
has part: O43677
boundary condition: true
is encoded by: hsa:4729
is encoded by: hsa:4725
is encoded by: hsa:4535
is encoded by: hsa:4708
has part: H7C5B8
is encoded by: hsa:4704
has part: B1AM93
is encoded by: hsa:4723
has part: O95139
has part: O95168
is encoded by: hsa:4718
is encoded by: hsa:55967
has part: Q7GXZ1
is encoded by: hsa:4714
is encoded by: hsa:4720
has part: P28331
has part: O75438
has part: O95167
has part: C9JT23
is encoded by: hsa:4695
is encoded by: hsa:4539
is encoded by: hsa:4712
has part: B7Z792
has part: Q13454
is encoded by: hsa:4541
has part: P17568
has part: O43181
has part: P03905
has part: O75251
is encoded by: hsa:4728
has part: Q6IB80
has part: O14561
has part: Q6FG42
is encoded by: hsa:4724
is encoded by: hsa:4707
has part: A8K761
has part: O95169
is encoded by: hsa:7991
has part: Q549M5
is encoded by: hsa:4716
is encoded by: hsa:4722
has part: P03915
has part: P03897
has part: P56556
is encoded by: hsa:4717
initial concentration: NaN
is encoded by: hsa:4540
is encoded by: hsa:4701
is encoded by: hsa:4713
constant: false
has part: Q6IBA0
has part: Q16718
has part: P19404
is encoded by: hsa:4697
has part: F8VQS7
has part: P56181
is encoded by: hsa:374291
has part: Q85KV6

metaM aacoa m
has only substance units: false
is: HMDB01484
name: acetoacetyl-CoA(4-)
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57286

metaR r0265
name: ATP:D-galactose 1-phosphotransferase Galactose metabolism EC:2.7.1.6
fast: false
reversible: false
product: MODEL1310110029#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:8908517 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaR r1527
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_b9c7e2b9_6689_42d9_8301_c8ca4a85a90c
is: Q86VV3
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: ENTPD1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:953

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
fast: false
product: MODEL1310110029#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
reversible: false

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
kinetic law: MODEL1310110029#
fast: false
name: glycine passive transport to peroxisome
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
reversible: true

metaR PPAn
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000176
name: inorganic diphosphatase, nuclear
kinetic law: MODEL1310110029#
reversible: false
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false

metaR MMMm
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
name: methylmalonyl-CoA mutase
reactant: MODEL1310110029#
is described by: ECO:0000269

metaM inost e
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00211
is: SBO:0000247
is: CHEBI:17268
boundary condition: false
name: myo-inositol
type: Species

metaR PROSTGF2t
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110029#
name: prostaglandin uniport
fast: false
reversible: true
is described by: ECO:0000269

metaR VALTA
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
reversible: true
product: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
name: valine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110029#
is: SBO:0000176

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM thf c
is: C00101
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
initial amount: NaN
constant: false
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
has only substance units: false
boundary condition: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c4cdcb58_91c4_47fe_abde_730994b215e4
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ACSL3
constant: false
has only substance units: false
is encoded by: hsa:2181
is: O95573
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a0e7a757_c6f6_41a7_ba19_1166244a6ca0
is encoded by: hsa:AV717590
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: _AV717590_1_m
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e46b0597_bb8e_41fa_b7da_0a2bd07e746c
type: Species
is: Q9Y3Y1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:65010
name: SLC26A6
initial amount: NaN

metaR DTTPtn
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_733eac22_47a6_4455_9f4b_ac69359349ae
is: P48448
type: Species
is: SBO:0000252
is encoded by: hsa:222
initial amount: NaN
name: ALDH3B2
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_540911cf_b56e_42db_802a_567c9c5c8bdb
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q9NQU1
is encoded by: hsa:65010
has only substance units: false
name: SLC26A6

metaM cmp m
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: HMDB00095
is: CHEBI:60377
constant: false
initial concentration: 1.0
type: Species

metaM co2 m
is: HMDB01967
is: SBO:0000247
has only substance units: false
is: CHEBI:16526
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
constant: false
initial concentration: 1.0
name: CO2
type: Species

metaM glu5sa m
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: CHEBI:17232
is: C01165
is: HMDB02104
boundary condition: false
type: Species
has only substance units: false
name: L-Glutamate 5-semialdehyde
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_cc80c0df_1a06_4d5d_b830_e271391e8ed8
type: Species
has only substance units: false
constant: false
name: AK7
initial concentration: NaN
is: Q96M32
initial amount: NaN
is encoded by: hsa:122481
boundary condition: true
is: SBO:0000252

metaR EX 34hpp
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.9
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c4865484_c0db_436f_9705_d8706708ff7b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2182
is: SBO:0000252
is: Q5JWV8
name: ACSL4
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR IMPC
product: MODEL1310110029#
reactant: MODEL1310110029#
name: IMP cyclohydrolase
modifier: MODEL1310110029#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction

metaM dgsn c
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
is: SBO:0000247
is: C00330
constant: false
is: CHEBI:17172
is: HMDB00085

metaM bildglcur c
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB03325
boundary condition: false
initial amount: NaN
type: Species
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471

metaR MI1345PP
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4460593a_572d_473d_a83f_c30ec8abe9e7
initial amount: NaN
type: Species
is: P52824
is encoded by: hsa:1609
name: DGKQ
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_85c00d32_55bf_4c01_807c_4840861f18de
has only substance units: false
name: CA9
boundary condition: true
is: Q16790
initial concentration: NaN
is encoded by: hsa:768
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM ncam e
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: C00153
boundary condition: false
is: HMDB01406
type: Species
is: SBO:0000247
is: CHEBI:0

metaM cmp n
is: CHEBI:60377
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
name: CMP(2-)
initial concentration: 1.0
boundary condition: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_4470b48e_8a98_4ac2_a8a7_2c82eb0f4cae
name: GPX7
is: SBO:0000252
boundary condition: true
constant: false
is: Q96SL4
has only substance units: false
is encoded by: hsa:2882
initial concentration: NaN
type: Species
initial amount: NaN

metaM utp e
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:46398
name: UTP(4-)
type: Species
boundary condition: false
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

http://identifiers.org/biomodels.db/MODEL1310110029#_3b33636e_0279_451d_8d96_93b5ddca7fb7
initial amount: NaN
is: SBO:0000252
constant: false
name: _H45672_1_m
is encoded by: hsa:H45672
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_0e28c86d_c7fe_4aae_bde6_f468ae005c37
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4725
name: NDUFS5
initial amount: NaN
boundary condition: true
is: Q6IBA0
initial concentration: NaN
is: SBO:0000252

metaR r0268
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
reversible: true
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000

metaM dcyt e
has only substance units: false
is: C00881
constant: false
is: HMDB00014
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: Deoxycytidine
is: CHEBI:15698

metaM 4ppcys m
type: Species
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:59458
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
constant: false
is: SBO:0000247

metaM idp n
type: Species
constant: false
is: HMDB03335
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: IDP(3-)
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
boundary condition: false

metaM itaccoa m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB03377
type: Species
name: itaconyl-CoA(5-)
constant: false
is: CHEBI:57381
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
initial concentration: 1.0

metaM HC02175 c
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
has only substance units: false
constant: false
is: CHEBI:27689
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR RE2660N
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: RE2660
reactant: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction

metaM nrpphr c
is: CHEBI:33569
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00216
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
type: Species

metaM pep c
is: HMDB00263
is: CHEBI:18021
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: C00074
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_50ad6f1c_a12e_4630_8dcc_cd6c149bd2f8
constant: false
type: Species
name: ENTPD2
initial amount: NaN
is: Q5SPY7
is encoded by: hsa:954
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM HC02121 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:58758
name: S-(hydroxymethyl)glutathione(1-)
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_b5c5841d_e104_4f58_94ad_2fed8ea85ac5
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q6FHI7
is: SBO:0000252
name: CA4
is encoded by: hsa:762
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b94eb69b_77ee_4738_b5e0_b6c68a348219
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:204
type: Species
initial amount: NaN
name: AK2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_82bbf451_fa1b_4f0f_9a68_e186f71d3d02
is: Q16635
is encoded by: hsa:6901
type: Species
constant: false
name: TAZ
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e811e2f4_7d0d_4c39_80b6_366be0bb9090
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9926
name: LPGAT1
has only substance units: false
initial concentration: NaN
is: Q92604
initial amount: NaN
type: Species
constant: false

metaM nh4 x
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
name: Ammonium
is: SBO:0000247
type: Species
is: C01342
has only substance units: false
is: CHEBI:28938

metaR DCTPtn
is: SBO:0000185
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
fast: false
name: dCTP diffusion in nucleus
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR UDPDOLPT L
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.117
is described by: ECO:0000000
modifier: MODEL1310110029#
reversible: false
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction

metaR r2367
kinetic law: MODEL1310110029#
type: Reaction
fast: false
reactant: MODEL1310110029#
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_878ae5dc_30fb_4dfa_8ef9_a941ba073f08
is: Q9NX14
boundary condition: true
name: NDUFB11
constant: false
is: SBO:0000252
is encoded by: hsa:54539
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:28002
type: Species
is: HMDB03952
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN

metaR VALTAm
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: valine transaminase, mitochondiral
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42

http://identifiers.org/biomodels.db/MODEL1310110029#_538c5348_4934_4710_9268_999e7d29cbe2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:MBOAT5
initial amount: NaN
has only substance units: false
type: Species
name: _MBOAT5_1_c
boundary condition: true

metaR LAPCOAl
name: lysosomal acid phosphorylase (CoA)
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
product: MODEL1310110029#
is: SBO:0000176
reversible: false
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000304
type: Reaction

metaM urate e
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
is: CHEBI:17775
constant: false
has only substance units: false
boundary condition: false
name: Urate
is: SBO:0000247
initial amount: NaN
type: Species
is: C00366

metaR CHOLK
type: Reaction
product: MODEL1310110029#
reversible: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: Choline kinase
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false

metaR RETH1e
product: MODEL1310110029#
reversible: false
name: retinyl ester hydrolase (9-cis), extracellular
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176

metaM lnlc e
is: HMDB00673
is: CHEBI:30245
type: Species
initial concentration: 1.0
name: linoleate
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-

metaM prostgi2 r
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
name: prostaglandin I2(1-)
type: Species
has only substance units: false
is: CHEBI:57403
initial concentration: 1.0

metaR PCHOLPm hs
reversible: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
modifier: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
name: choline phosphatase
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9af7a41c_db02_483e_b004_59371405cff9
has only substance units: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_8ec12317_5464_4d54_8436_52d224feb4b8
has only substance units: false
name: _AI990637_1_x
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI990637

metaM nrpphr e
constant: false
is: CHEBI:33569
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00216
type: Species
name: Norepinephrine

metaR It
kinetic law: MODEL1310110029#
type: Reaction
name: Iodide uniport
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_6561ca85_61a9_44aa_ba8b_9f77718e5192
name: IDH1
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: O75874
is encoded by: hsa:3417

metaR HMBS
is version of: http://identifiers.org/ec-code/2.5.1.61
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000254
name: hydroxymethylbilane synthase

metaM HC02175 e
is: SBO:0000247
initial concentration: 1.0
name: caprate
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
has only substance units: false
is: CHEBI:27689
type: Species
initial amount: NaN

metaR GLXO2p
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
name: glyoxylate oxidase, peroxisomal
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR MTHFD2
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD)
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#

metaR SUCCTD
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM na1 r
name: sodium(1+)
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:29101
is: HMDB00588
boundary condition: false
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

http://identifiers.org/biomodels.db/MODEL1310110029#_61040991_4f89_48e2_a107_1ca232b538ad
initial concentration: NaN
is encoded by: hsa:23428
constant: false
is: Q86U05
has only substance units: false
name: SLC7A8
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM udpg r
initial concentration: 1.0
constant: false
is: CHEBI:58367
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00286
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
type: Species

metaR r2366
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
type: Reaction

metaM tsul c
is: SBO:0000247
constant: false
initial amount: NaN
name: thiosulfate(2-)
is: CHEBI:16094
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_265b3513_172a_43d2_afdf_7b0234f4d64f
constant: false
is: Q9UN76
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC6A14
is encoded by: hsa:11254
initial concentration: NaN

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is: SBO:0000185
reversible: false
type: Reaction
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaM HC02179 e
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate
is: CHEBI:34306
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM ump r
is: CHEBI:57865
is: HMDB00288
type: Species
name: UMP
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: SBO:0000247
boundary condition: false

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000304
reversible: true
product: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
is: SBO:0000185
kinetic law: MODEL1310110029#

metaR SRTNt6 2 r
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_558d226d_3cf1_4c41_bc5b_0771addab49e
has only substance units: false
is encoded by: hsa:55500
type: Species
name: ETNK1
initial amount: NaN
is: Q9HBU6
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r2369
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaR FACOAL180i
fast: false
name: C180 fatty acid activation
reversible: false
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000269

metaM urate c
type: Species
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
is: HMDB00289
is: CHEBI:17775
boundary condition: false
name: Urate
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR FKYNH
reactant: MODEL1310110029#
type: Reaction
name: N-Formyl-L-kynurenine amidohydrolase
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176

metaM xol27oh m
boundary condition: false
name: 26-hydroxycholesterol
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
is: HMDB02103

metaR GNDer
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR DAGt
is: SBO:0000185
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
name: diacylglycerol transport
kinetic law: MODEL1310110029#

metaM co2 r
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16526
constant: false
is: C00011
type: Species
boundary condition: false
name: CO2
has only substance units: false
initial amount: NaN

metaR PPAt
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
name: Propionate transport, diffusion
reactant: MODEL1310110029#
reversible: false
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185

metaR r0512
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR r2368
reactant: MODEL1310110029#
is: SBO:0000185
reversible: true
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport

metaM duri c
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00012
is: C00526
initial concentration: 1.0
name: Deoxyuridine
is: CHEBI:16450
type: Species
is: SBO:0000247

metaR NDPK10
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
fast: false
product: MODEL1310110029#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_574e699c_8613_4f68_ae3b_0daf26f2820a
boundary condition: true
constant: false
is encoded by: hsa:3098
has only substance units: false
initial concentration: NaN
is: B3KXY9
type: Species
name: HK1
is: SBO:0000252
initial amount: NaN

metaR RNMK
kinetic law: MODEL1310110029#
is described by: ECO:0000269
name: ribosylnicotinamide kinase
fast: false
reversible: false
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.22
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:

metaM occoa m
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: CHEBI:57386
type: Species
is: HMDB01070
initial concentration: 1.0
boundary condition: false
constant: false
is: C01944
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
is: SBO:0000247

metaR GTHO
is version of: http://identifiers.org/ec-code/1.8.1.7
is described by: ECO:0000254
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: glutathione oxidoreductase
fast: false
is: SBO:0000176

metaR r0474
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110029#

metaR RE1534M
type: Reaction
reversible: true
product: MODEL1310110029#
name: RE1534
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176

metaR r2376
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000

metaM oxa c
is: HMDB02329
boundary condition: false
is: CHEBI:30623
has only substance units: false
initial concentration: 1.0
constant: false
name: oxalate(2-)
type: Species
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_e02fe066_8cbc_4290_88e5_9b8fc4c20f47
has only substance units: false
name: _D87002_1_m
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:D87002
initial concentration: NaN
boundary condition: true
type: Species

metaR GLYt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: glycine reversible transport via proton symport
modifier: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000304
reversible: true
type: Reaction
reactant: MODEL1310110029#

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
name: Transport reaction
fast: false
reversible: false
reactant: MODEL1310110029#

metaR r1731
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ef3b498f_8742_4470_9674_a21d818d4d30
boundary condition: true
name: NDUFA6
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P56556
initial amount: NaN
has only substance units: false
is encoded by: hsa:4700

metaM mercplac c
name: 3-Mercaptolactate
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/8118
is: HMDB02127
constant: false
initial concentration: 1.0
is: C05823

metaM thyox L e
type: Species
initial concentration: 1.0
is: HMDB00248
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
is: CHEBI:18332

metaR r2377
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_6329e5f4_50dd_4c74_bc10_d522db6fc23b
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:55753
type: Species
initial concentration: NaN
is: Q9ULD0
boundary condition: true
name: OGDHL
has only substance units: false

metaR GTHP
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.11.1.15
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase
modifier: MODEL1310110029#

metaM digalside hs c
name: Digalactosylceramide
is: http://identifiers.org/pubchem.compound/8383
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: C06126

metaR CYOR u10m
is: SBO:0000185
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110029#
is described by: ECO:0000134
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
name: ubiquinol-6 cytochrome c reductase, Complex III

metaM leu L e
type: Species
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
name: L-leucine
is: HMDB00687
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15603
constant: false
boundary condition: false

metaM HC01712 m
is: SBO:0000247
type: Species
constant: false
boundary condition: false
name: S-Glutaryldihydrolipoamide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
initial amount: NaN
is: CHEBI:28391

http://identifiers.org/biomodels.db/MODEL1310110029#_6373c05c_b4f4_4c97_a154_781f3017c392
constant: false
is encoded by: hsa:4705
is: SBO:0000252
boundary condition: true
is: O95299
initial concentration: NaN
initial amount: NaN
name: NDUFA10
has only substance units: false
type: Species

metaR FACOAL160i
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C160 fatty acid activation
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_a8021894_cfa8_4714_bcff_31bd342a623f
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4718
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q549M5
name: NDUFC2

metaR TYROXDAc
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4

metaM duri e
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:16450
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
initial concentration: 1.0
is: HMDB00012
is: C00526

metaR GSNt
product: MODEL1310110029#
fast: false
name: guanosine facilated transport in cytosol
is: SBO:0000185
type: Reaction
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110029#

metaR r2374
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_95430d85_a097_466e_b85d_258417a8e202
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1109
is: P17516
is: SBO:0000252
has only substance units: false
name: AKR1C4

http://identifiers.org/biomodels.db/MODEL1310110029#_de87b7b2_8d8b_40d4_a6d9_2c1848796afe
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NME1
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4830

metaM HC01118 r
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57310
name: presqualene diphosphate(3-)
constant: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR r0472
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110029#

metaM CE2838 e
name: maltononaose
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
boundary condition: false
type: Species
is: C01936
constant: false
initial concentration: 1.0

metaR PPItx
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
name: Diphosphate transporter, peroxisome
type: Reaction

metaM 6a2ohxnt x
boundary condition: false
initial amount: NaN
name: 6-amino-2-oxohexanoic acid
is: SBO:0000247
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: HMDB12151
initial concentration: 1.0
constant: false
is: CHEBI:17534
has only substance units: false

metaM oxa e
is: CHEBI:30623
name: oxalate(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
is: HMDB02329
type: Species
is: SBO:0000247

metaR SUCCt4 2
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
reactant: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000269
name: succinate transport via sodium symport
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#

metaR PPPG9tm
name: protoporphyrinogen IX mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_1aa77e82_adab_4842_b70a_fc7ec58864cd
has only substance units: false
is: Q9NTN3
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:23169
name: SLC35D1

metaR H2O2tp
reactant: MODEL1310110029#
fast: false
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: hydrogen peroxide peroxisomal transport via diffusion
product: MODEL1310110029#

metaR r0680
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR r2375
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR GLYCLTtp
name: glycolate transport into peroxisome
reversible: false
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD

metaM pi x
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:43474
is: HMDB00973
name: hydrogenphosphate
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_b94b7586_a963_4851_979d_01be5efd9895
is: SBO:0000252
is: O00217
constant: false
initial concentration: NaN
name: NDUFS8
type: Species
boundary condition: true
is encoded by: hsa:4728
initial amount: NaN
has only substance units: false

metaR RE1903R
product: MODEL1310110029#
reversible: true
name: RE1903
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:

metaR MECOALm
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110029#
is described by: ECO:0000212
reactant: MODEL1310110029#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

metaM leu L c
constant: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
initial amount: NaN
name: L-leucine
initial concentration: 1.0
is: CHEBI:15603
boundary condition: false
is: HMDB00687
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e6d1d412_3066_49b6_9ba8_2212d3c3fd24
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:2645
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110029#_6fc44c3d_bb54_4bb6_a586_bcb56d431a19
is encoded by: hsa:1718
is: SBO:0000252
type: Species
initial amount: NaN
is: Q15392
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DHCR24

http://identifiers.org/biomodels.db/MODEL1310110029#_89204c85_6694_48a9_a021_67c76b3da5eb
is: P13073
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: COX4I1
boundary condition: true
is encoded by: hsa:1327

metaR r2372
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false

metaR LPCOXp
is: SBO:0000176
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: L-pipecolate oxidase, peroxisomal
reversible: false
reactant: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false
product: MODEL1310110029#

metaR ARAB Lt
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
reactant: MODEL1310110029#
is: SBO:0000185

metaM 4abut c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3628
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: C00334

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR r1492
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
product: MODEL1310110029#
name: Utilized transport
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction

metaM hco3 c
is: CHEBI:17544
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: Bicarbonate
is: C00288
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
is: HMDB00595

metaR URIt5le
type: Reaction
reversible: false
name: uridine transport in via sodium symport (1:2)
modifier: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r1847
is described by: ECO:0000000
product: MODEL1310110029#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110029#

metaR FACOAL204
product: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110029#_7056e54e_8901_4d88_b474_6c33ce8337ca
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: AICDA
is: Q546Y9
is encoded by: hsa:57379
is: SBO:0000252

metaM thr L c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16857
constant: false
type: Species
is: HMDB00167
name: L-threonine
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
boundary condition: false

metaR CDS
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: phosphatidate cytidylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_1fe1c199_34ac_4da7_9886_b2fbd91a56c6
initial amount: NaN
constant: false
is encoded by: hsa:4539
boundary condition: true
has only substance units: false
is: Q7GXZ4
name: ND4L
initial concentration: NaN
type: Species
is: SBO:0000252

metaR CITtam
name: citrate transport, mitochondrial
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#

metaR r2373
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_5dfa2d3e_b551_4af4_af18_11edcb41328e
type: Species
constant: false
is encoded by: hsa:5538
is: Q6FGQ4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: PPT1

metaM thr L e
is: HMDB00167
constant: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
name: L-threonine
has only substance units: false
is: SBO:0000247
is: CHEBI:16857
initial concentration: 1.0

metaR LGTHL
reversible: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.4.1.5
is described by: ECO:0000269
name: lactoylglutathione lyase
fast: false

metaM cys L c
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17561
is: HMDB00574
constant: false
initial amount: NaN
boundary condition: false

metaM retinol cis 13 c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:45479
name: 13-cis-retinol
is: HMDB06217
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_11e86e52_7d15_498d_99c9_c7c7b5ecc9f0
constant: false
is encoded by: hsa:4697
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: O00483
name: NDUFA4
has only substance units: false

metaM digalside hs g
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/8383
boundary condition: false
is: C06126
constant: false
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
type: Species
name: Digalactosylceramide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e7c7d9ff_cb2f_4d93_8a6a_2fcfc57cb7ad
initial amount: NaN
type: Species
boundary condition: true
is: P27144
is: SBO:0000252
constant: false
has only substance units: false
name: AK4
initial concentration: NaN
is encoded by: hsa:205

metaM lys L x
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:32551
name: L-lysinium(1+)
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: hydrogenphosphate
boundary condition: false
is: SBO:0000247
is: HMDB00973
is: C00009
has only substance units: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR RETt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
reactant: MODEL1310110029#
name: Retinol transport via faciliated diffusion
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR NDP10ex
kinetic law: MODEL1310110029#
type: Reaction
reversible: false
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269
name: nucleoside-diphosphatase (IDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_d3e2c918_a78b_47eb_9654_b5b4905e3691
initial amount: NaN
constant: false
is encoded by: hsa:4514
has only substance units: false
name: COX3
type: Species
boundary condition: true
is: P00414
initial concentration: NaN
is: SBO:0000252

metaR r0932
reversible: true
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Transport reaction
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_670ddb36_150d_4349_a026_9e6a37a17e7f
is: B4DUG1
has only substance units: false
initial amount: NaN
type: Species
name: SLC24A1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9187
boundary condition: true
constant: false

metaR NDP3ex
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
is: SBO:0000176
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is described by: ECO:0000269
fast: false
reactant: MODEL1310110029#
type: Reaction
reversible: false
modifier: MODEL1310110029#

metaR CPPPGO
fast: false
type: Reaction
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000304
name: coproporphyrinogen oxidase (O2 required)
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.3.3

metaR DM datp n
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM datp(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_48aad5aa_4a35_45f6_91e2_26c08ff4edb3
type: Species
initial concentration: NaN
name: SLC7A10
is: SBO:0000252
is encoded by: hsa:56301
has only substance units: false
boundary condition: true
is: Q9NS82
initial amount: NaN
constant: false

metaR DURIt
is: SBO:0000185
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: deoxyuridine transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_7afe79e1_a3c3_4ba0_bf56_330c695e53de
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AA021081
name: _AA021081_1_r
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_d1dc099e_69fa_4d87_90a8_c115029c1bf9
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2819
initial concentration: NaN
name: GPD1
is: F8W1L5
has only substance units: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_976f98b4_98db_459d_b18c_eeb320784fed
name: NDUFB10
constant: false
has only substance units: false
is encoded by: hsa:4716
type: Species
boundary condition: true
is: A8K761
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r2371
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110029#
is described by: ECO:0000000

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Utilized transport

metaM cys L e
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
is: CHEBI:17561
name: L-cysteine
is: HMDB00574
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR INSTt4
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: inositol transport via sodium symport
type: Reaction

metaR HPYRDC
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
name: hydroxypyruvate decarboxylase
kinetic law: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_89fe22c6_2d68_4a2c_a083_d1d7a1c5ceb4
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3945
is: SBO:0000252
is: P07195
name: LDHB
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_f0217a26_e6a1_4e55_b727_64be082b5d17
is: P32321
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1635
name: DCTD
initial concentration: NaN
initial amount: NaN
constant: false

metaR RADH4
product: MODEL1310110029#
reactant: MODEL1310110029#
name: retinal dehydrogenase (NADPH)
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:11606944 NOTES:IT
fast: false
kinetic law: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_8470dbe5_77dd_4e57_adca_0c677d4a6528
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: P09917
has only substance units: false
is encoded by: hsa:240
name: ALOX5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_becc64a8_508f_4436_9962_55ce3af58d65
type: Species
is: Q8TE04
boundary condition: true
initial concentration: NaN
name: PANK1
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53354

http://identifiers.org/biomodels.db/MODEL1310110029#_5d3a0831_4127_457a_b399_ebdce79d5f23
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P19801
name: ABP1
is encoded by: hsa:26
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_66ff3827_7fef_4eba_ae02_5e54352f5f31
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: CA3
type: Species
is: P07451
is encoded by: hsa:761
has only substance units: false
initial concentration: NaN

metaM leu L m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: L-leucine
has only substance units: false
is: SBO:0000247
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
is: HMDB00687

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: CHEBI:58147
initial concentration: 1.0
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
is: HMDB00978
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaR r1843
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM prostgf2 c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
name: prostaglandin F2alpha(1-)
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: HMDB01139

metaM gcald c
type: Species
is: CHEBI:17071
has only substance units: false
name: glycolaldehyde
is: SBO:0000247
initial concentration: 1.0
is: HMDB03344
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266

http://identifiers.org/biomodels.db/MODEL1310110029#_241843e3_3a8b_43b0_b5e6_fd5cb329bc39
is: Q92820
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: GGH
has only substance units: false
is encoded by: hsa:8836
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_cb06f89c_e95b_460a_9419_3078f92f87f0
type: Species
name: ECHS1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1892
is: P30084
initial concentration: NaN
is: SBO:0000252

metaR OXAtp
is: SBO:0000185
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110029#
name: oxalate transport out of peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_aafa774a_5cf7_4f7a_bf48_3cd49f0c232e
is encoded by: hsa:5498
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PPOX
type: Species
initial concentration: NaN
initial amount: NaN
is: P50336

metaM HC01231 c
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58480
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN

metaM fum m
boundary condition: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
is: HMDB00134
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Fumarate
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_319d754e_ad30_4df8_babd_40dd7a7178c8
initial amount: NaN
type: Species
name: _NM_001929_1_c
has only substance units: false
is encoded by: hsa:NM 001929
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaM gthox c
is: CHEBI:58297
name: Oxidized glutathione
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: C00127
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB03337
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e8c95b16_b786_4b12_b7c1_1164ab4332dd
initial concentration: NaN
is: P37837
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6888
name: TALDO1
initial amount: NaN

metaR r0686
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR RE3628M
is: SBO:0000176
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
name: RE3628
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110029#

metaM HC02193 e
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
name: glycolithocholate
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:60008
is: SBO:0000247

metaR r1630
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#

metaR P450SCC1m
reactant: MODEL1310110029#
name: cholesterol monooxygenase
is described by: ECO:0000134
reversible: true
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110029#

metaR r0360
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
modifier: MODEL1310110029#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_10abbe27_5ad6_4527_96ff_bdc6d11bd143
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: PYCRL
boundary condition: true
is encoded by: hsa:65263
type: Species
has only substance units: false
is: Q53H96

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR PMTCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
fast: false

metaM 5HPET c
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial amount: NaN
is: CHEBI:57450
type: Species
is: SBO:0000247
is: HMDB01193
initial concentration: 1.0
name: 5(S)-HPETE(1-)
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d757d84f_2780_4d88_bad9_383094c2d7e4
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:200010
initial concentration: NaN
constant: false
name: SLC5A9
type: Species
is: E9PAK4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_990ae5d8_626c_481d_916d_0b4505cacad2
is: SBO:0000252
has only substance units: false
is: P48735
name: IDH2
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:3418
type: Species
initial amount: NaN

metaM xtsn c
boundary condition: false
type: Species
name: xanthosine
is: HMDB00299
initial amount: NaN
constant: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: CHEBI:18107
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r1631
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR ALOX52
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
fast: false
name: Arachidonate 5-lipoxygenase
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.13.11.34
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764

metaM hco3 e
is: SBO:0000247
is: CHEBI:17544
name: Bicarbonate
is: C00288
is: HMDB00595
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_228d8f07_759c_443a_bf22_f3cef4f62eb0
type: Species
has only substance units: false
name: _AA629629_1_m
is encoded by: hsa:AA629629
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaM 4abut e
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00112
initial amount: NaN
is: C00334
is: CHEBI:3628
constant: false

metaR CYTK5n
kinetic law: MODEL1310110029#
name: cytidylate kinase (CMP),nuclear
fast: false
modifier: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
reactant: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_e9a7ce80_008c_451b_8da8_c5e8dbe13c23
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:284111
name: SLC13A5
is: Q86YT5
is: SBO:0000252
has only substance units: false
constant: false

metaR HISCAT1
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110029#
fast: false
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/2.7.7.72
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.4.13

metaR LNLCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_275deb22_320e_487e_b43b_1c46b9403506
boundary condition: true
is: P14854
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:1340
type: Species
initial concentration: NaN
name: COX6B1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_49796074_174b_4db0_a65f_5df56d9b1163
constant: false
is encoded by: hsa:57379
is: SBO:0000252
is: Q546Y9
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: AICDA

http://identifiers.org/biomodels.db/MODEL1310110029#_07fe98d8_6796_4525_a7c0_f17b9fcda4e8
boundary condition: true
is encoded by: hsa:43
has only substance units: false
is: SBO:0000252
constant: false
name: ACHE
initial amount: NaN
is: P22303
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_9a8e7f85_6994_4f15_9edf_c3fe3f74b5fa
constant: false
name: SGPP1
type: Species
is encoded by: hsa:81537
is: Q9BX95
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR FADH2ETC
kinetic law: MODEL1310110029#
reversible: false
name: Complex II reaction for respiratory chain
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r0688
is described by: ECO:0000000
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
product: MODEL1310110029#
reversible: true
type: Reaction
reactant: MODEL1310110029#
fast: false

metaM HC02193 c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
name: glycolithocholate
boundary condition: false
initial amount: NaN
is: CHEBI:60008
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_2c827023_2486_4d0a_9f3d_e7f744d6c79e
initial concentration: NaN
is encoded by: hsa:205
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: AK4

metaR r1632
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#

metaR r1384
reversible: true
type: Reaction
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#

metaR ILETA
fast: false
name: isoleucine transaminase
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:

metaR NDPK4n
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110029#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110029#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110029#

metaR NCAMUP
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
type: Reaction
name: Nicotinamide acid uptake

http://identifiers.org/biomodels.db/MODEL1310110029#_08010e0c_f96a_4e10_9e49_54e94da01497
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
is: P21912
name: SDHB

metaR ECOAH9m
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110029#_c3231a89_04a9_43ad_b405_3a2f3301aa0f
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: COX5B
is: Q53YB7
is encoded by: hsa:1329

metaR ADK1
is described by: ECO:0000269
modifier: MODEL1310110029#
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
fast: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_65a43ca1_7d36_4cd6_9f0b_b87824dc4280
name: NDUFB6
is: Q5VYT2
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4712

http://identifiers.org/biomodels.db/MODEL1310110029#_70b06869_1074_4516_9261_6ff126688d73
initial amount: NaN
is encoded by: hsa:286297
initial concentration: NaN
is: SBO:0000252
type: Species
name: _286297_1_c
constant: false
has only substance units: false
boundary condition: true

metaR MTHFC
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
name: methenyltetrahydrofolate cyclohydrolase
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5

metaR PI345P5P
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
type: Reaction
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: false
product: MODEL1310110029#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

metaM xylu L c
initial amount: NaN
is: HMDB00751
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: L-xylulose
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
is: CHEBI:17399

metaR UMPK7n
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is described by: ECO:0000269
name: UMP kinase (dGTP),nuclear
kinetic law: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM 4mlacac c
boundary condition: false
type: Species
name: 4-maleylacetoacetate
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:17105
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: HMDB02052
initial concentration: 1.0
has only substance units: false

metaM HC00361 c
is: CHEBI:58335
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
name: sedoheptulose 1,7-bisphosphate(4-)

http://identifiers.org/biomodels.db/MODEL1310110029#_b77db95f_09e7_4c26_b410_1ddad05582e8
constant: false
initial amount: NaN
has only substance units: false
is: Q86YI5
initial concentration: NaN
type: Species
name: DLAT
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1737

metaR r0365
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false

metaM HC02206 c
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: CHEBI:57399
initial amount: NaN
initial concentration: 1.0
name: prostaglandin C1(1-)

http://identifiers.org/biomodels.db/MODEL1310110029#_4895bbd2_5134_481c_a6d9_f1a5e9cf7309
is: Q9UHI5
boundary condition: true
has only substance units: false
is encoded by: hsa:23428
constant: false
is: SBO:0000252
name: SLC7A8
type: Species
initial concentration: NaN
initial amount: NaN

metaR DIGALSGALSIDEtg
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
name: digalsgalside hs intracellular transport
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

http://identifiers.org/biomodels.db/MODEL1310110029#_c826766b_0fcf_44be_b4fb_0acd0a305845
boundary condition: true
is: SBO:0000252
has only substance units: false
name: HMGCLL1
initial amount: NaN
is: Q9NT06
type: Species
is encoded by: hsa:54511
constant: false
initial concentration: NaN

metaR LEUKTRE4t
product: MODEL1310110029#
is described by: ECO:0000000
name: leukotriene E4 transport
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false

metaM dgmp c
is: SBO:0000247
initial amount: NaN
is: C00362
initial concentration: 1.0
is: HMDB01044
constant: false
has only substance units: false
name: dGMP
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673

metaM leuktrE4 c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57462
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
has only substance units: false
name: leukotriene E4(1-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_d686acba_2fd6_46eb_880f_6c713fa6ffe4
is: SBO:0000252
constant: false
name: AK2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: P54819
is encoded by: hsa:204
boundary condition: true

metaR RE1523M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
name: RE1523
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110029#
fast: false

metaR H2O2tn
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: hydrogen peroxide nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_cc2d224d_32fe_41c7_a9cf_a0a9ae673b25
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: CYB5D1
initial amount: NaN
is: Q6P9G0
is encoded by: hsa:124637
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_19cd947e_0609_43b2_975b_bfd5f16ea9ee
name: SLC12A7
has only substance units: false
initial concentration: NaN
is: Q9Y666
type: Species
is encoded by: hsa:10723
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_8caffee4_8345_4dd5_8eea_77b7ac072cd1
name: HADHA
is: E9KL44
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3030
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_1d9864eb_cd4d_4d1a_b2f6_fbb8284e32a6
is: P23634
is encoded by: hsa:493
boundary condition: true
initial concentration: NaN
name: ATP2B4
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR RE1796R
is version of: http://identifiers.org/ec-code/1.1.1.145
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
name: RE1796

metaR ADK3
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is described by: ECO:0000269
product: MODEL1310110029#
is: SBO:0000176
name: adentylate kinase (GTP)
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
modifier: MODEL1310110029#

metaR r0683
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is described by: ECO:0000000
modifier: MODEL1310110029#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110029#
reactant: MODEL1310110029#

metaM pail4p hs c
constant: false
is: SBO:0000247
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: CHEBI:58178
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_d1d0c078_f004_467c_a1a0_54145e4af552
name: MBOAT7
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:79143
is: Q96N66
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_04813af0_348a_48f4_b0c4_0f425eb018af
type: Species
has only substance units: false
is: Q9NQR4
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: NIT2
boundary condition: true
is encoded by: hsa:56954

metaM prostgf2 e
is: HMDB01139
initial amount: NaN
is: CHEBI:57404
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
type: Species
name: prostaglandin F2alpha(1-)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_52ccc905_3850_4049_8d39_833e901c2e72
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P48651
initial amount: NaN
name: PTDSS1
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:9791

metaR RE3568C
fast: false
type: Reaction
reversible: true
is: SBO:0000176
name: RE3568
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#

metaR r1841
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_030c37ec_866d_401e_b0e1_df1f0f48ff71
initial concentration: NaN
name: _NM_013421_1_m
type: Species
initial amount: NaN
is encoded by: hsa:NM 013421
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaM ach c
boundary condition: false
type: Species
is: HMDB00895
has only substance units: false
is: CHEBI:15355
name: acetylcholine
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DIGALSGALSIDEte
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: digalsgalside hs transport

metaR MTHFD
is described by: ECO:0000134
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.5.1.5
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
type: Reaction
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_792625fd_6553_4107_8f95_9162a04765e4
name: PRDX1
is encoded by: hsa:5052
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM leuktrE4 e
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57462
is: HMDB02200
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
name: leukotriene E4(1-)
constant: false

metaM thyox L c
has only substance units: false
initial amount: NaN
is: CHEBI:18332
is: HMDB00248
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_40d648d8_afde_4f25_ac8a_89bab0a78fb7
is: Q99755
boundary condition: true
name: PIP5K1A
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:8394
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_21d9c789_3880_4f01_bd6e_f36405ef4882
boundary condition: true
constant: false
is encoded by: hsa:AI934540
initial concentration: NaN
name: _AI934540_1_c
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM HC01610 e
type: Species
initial amount: NaN
is: CHEBI:28607
initial concentration: 1.0
is: SBO:0000247
constant: false
name: CoproporphyrinogenI
boundary condition: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_bd3417bc_79c3_438a_9e28_3c3e3743794a
constant: false
is encoded by: hsa:2629
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: GBA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_266ef04a_4515_4cf5_9b6a_11d27e0dbeb0
type: Species
is: B4DG68
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4842
boundary condition: true
name: NOS1
initial amount: NaN

metaR HPYRR2x
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.2.4
reactant: MODEL1310110029#
type: Reaction
name: hydroxypyruvate reductase (NADH)
is: SBO:0000176
modifier: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b71cf5ad_de57_4c1c_b519_77b64a1da0d2
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P15531
constant: false
initial amount: NaN
name: NME1
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110029#_95ac8825_651a_401c_8b8c_a0b031a87721
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ITPKB
is encoded by: hsa:3707
constant: false
initial amount: NaN
boundary condition: true
is: P27987
type: Species

metaR r1842
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#

metaR r0475
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110029#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaR PUNP7
modifier: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_a8e96f15_0b3c_40a5_992e_7c9314603d8d
boundary condition: true
name: ALDH1A3
constant: false
is encoded by: hsa:220
type: Species
initial concentration: NaN
is: P47895
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r1164
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is: SBO:0000176
name: EC:2.3.1.26
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110029#

metaR CDIPTr
modifier: MODEL1310110029#
reversible: true
name: phosphatidylinositol synthase (Homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.11
reactant: MODEL1310110029#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD

metaM CE2421 m
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02329
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b84a9994_031d_4a7c_8715_30802537e75c
has only substance units: false
is encoded by: hsa:1350
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: COX7C
is: P15954
initial concentration: NaN

metaR r1626
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
fast: false

metaR HACD9m
is described by: ECO:0000134
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is: SBO:0000176
reactant: MODEL1310110029#
fast: false
type: Reaction
kinetic law: MODEL1310110029#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM g3p c
type: Species
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
boundary condition: false
constant: false
is: CHEBI:58027
is: C00661
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01112

metaR DURAD
product: MODEL1310110029#
reactant: MODEL1310110029#
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110029#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
is described by: ECO:0000269

metaR HISSNAT5tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_e71cdfd3_d8b3_4131_a49e_a2713dccb2c6
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AF116616
name: _AF116616_1_m
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r2096
reversible: true
product: MODEL1310110029#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_e8a94bbc_a5a8_4e96_9188_5f3f31d55824
initial amount: NaN
initial concentration: NaN
is: P49327
is encoded by: hsa:2194
boundary condition: true
constant: false
has only substance units: false
name: FASN
is: SBO:0000252
type: Species

metaR r0142
reversible: false
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110029#_21458a51_f336_4fbf_84d4_c9ee5a5afeb6
initial concentration: NaN
type: Species
constant: false
name: ALDH3B2
has only substance units: false
initial amount: NaN
is: P48448
boundary condition: true
is encoded by: hsa:222
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_70c05604_8d31_4b4c_b50f_3f374e3e762e
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: _D87002_1_e
is encoded by: hsa:D87002
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_81b0a789_7f5d_4409_b5ea_6c1d96056616
initial amount: NaN
is: SBO:0000252
is: P21589
type: Species
name: NT5E
constant: false
initial concentration: NaN
is encoded by: hsa:4907
boundary condition: true
has only substance units: false

metaR UDPGLCAter
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is: SBO:0000185
fast: false

metaR O2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
name: O2 transport (diffusion)
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
type: Reaction

metaR PRO Dtde
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
type: Reaction
name: D-proline transport, extracellular
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110029#_1d1bf1c4_ec14_48bd_872e_a1862a8b4056
name: FDFT1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P37268
constant: false
initial amount: NaN
is encoded by: hsa:2222

metaM gchola e
initial concentration: 1.0
name: glycocholate
boundary condition: false
constant: false
is: HMDB00138
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
is: SBO:0000247
type: Species

metaM ach e
name: acetylcholine
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15355
type: Species
is: HMDB00895
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaM CE2839 e
type: Species
is: C01936
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
constant: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
has only substance units: false
name: maltodecaose
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR SO4t4 2
name: sulfate transport via sodium symport
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false

metaM 2dr5p c
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
is: HMDB01031
has only substance units: false

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true

metaM hdca r
initial amount: NaN
name: Hexadecanoate (n-C16:0)
is: C00249
is: HMDB00220
boundary condition: false
constant: false
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_ad631935_ca04_4855_af3c_a65d1fc5a59c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55224
has only substance units: false
constant: false
name: ETNK2
type: Species
initial concentration: NaN
boundary condition: true
is: Q9NVF9

metaM ala D c
is: HMDB01310
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
is: CHEBI:15570
initial amount: NaN
name: D-alanine
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR r2095
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaM pheme m
has only substance units: false
constant: false
is: C00032
initial concentration: 1.0
is: HMDB03178
initial amount: NaN
is: CHEBI:17627
type: Species
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: SBO:0000247
boundary condition: false

metaR P5CDm
modifier: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is: SBO:0000176
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
kinetic law: MODEL1310110029#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false

metaR r2094
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FUMTSULtm
type: Reaction
name: Fumarate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false

metaM lys L m
is: HMDB00182
boundary condition: false
type: Species
name: L-lysinium(1+)
has only substance units: false
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_78a9829d_cd1e_4e56_ba8b_6027e9495357
name: DGKE
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8526
initial amount: NaN
is: A1L4Q0

metaR r0033
fast: false
product: MODEL1310110029#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM xol7aone m
name: 7alpha-hydroxycholest-4-en-3-one
type: Species
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
boundary condition: false
initial concentration: 1.0
is: HMDB01993
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR PHEACGLNt
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
fast: false
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
name: PHEACGLN extracellular transport via diffusion
product: MODEL1310110029#
is: SBO:0000185

metaR r2098
modifier: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gthrd c
name: Reduced glutathione
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
is: C00051
is: HMDB00125
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2e4f1ae7_abcb_4984_b3a8_b6b95cbdf5a4
initial amount: NaN
name: BDH1
type: Species
constant: false
is encoded by: hsa:622
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR OROTGLUt
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
product: MODEL1310110029#
name: OROTGLUt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_12b25864_4618_4095_adba_b6137dd77010
is encoded by: hsa:57468
initial amount: NaN
name: SLC12A5
type: Species
initial concentration: NaN
boundary condition: true
is: Q9H2X9
has only substance units: false
is: SBO:0000252
constant: false

metaM 44mzym r
is: HMDB01286
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 14-demethyllanosterol
constant: false
is: CHEBI:18364
initial amount: NaN
type: Species
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0

metaM L2aadp m
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
has only substance units: false
initial amount: NaN
is: CHEBI:58672
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-2-aminoadipate(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_3a57875e_7e0d_4fa0_aaf2_72d0e0a6451e
is encoded by: hsa:5313
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PKLR
is: P30613
type: Species
constant: false

metaR r1628
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
reversible: true

metaR 5MTHFt2le
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000134
fast: false
is: SBO:0000185
reversible: true
name: 5-methyltetrahydrofolate transport via anion exchange

http://identifiers.org/biomodels.db/MODEL1310110029#_03c29616_4743_485a_8463_2ad4dca5afeb
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:131
is: P40394
is: SBO:0000252
initial amount: NaN
name: ADH7
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_5b383c55_c0ed_4969_b7d6_3c0bddf87407
constant: false
is: Q6IBB5
has only substance units: false
is encoded by: hsa:4694
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFA1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_1f11f350_f97d_4585_8c82_1b1236124a04
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _HG2846_HT2983_1_c
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:HG2846-HT2983

metaR r2097
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#

metaR GGH 7DHFe
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110029#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_f4b9d81c_c21b_44b5_8dfc_b4c84fd06808
is encoded by: hsa:AD000092
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AD000092_1_c
type: Species
constant: false

metaR IDPtn
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110029#
is described by: ECO:0000000
name: IDP nuclear transport
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_65cba8c2_4b5c_4f3e_b736_8b4c2ba95a5e
is: P07205
name: PGK2
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5232
constant: false
is: SBO:0000252

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
is: C00119
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58017
has only substance units: false
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: HMDB00280
constant: false

metaM HC02206 e
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
name: prostaglandin C1(1-)
boundary condition: false
constant: false
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110029#_f31b4573_e853_46d7_a1e8_eec9594faf7e
is: Q16831
initial concentration: NaN
name: UPP1
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:7378

metaR r1627
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
reversible: true
type: Reaction
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_663feef3_7d57_4e01_95b8_18b6513e7ecb
initial concentration: NaN
initial amount: NaN
is: Q02338
name: BDH1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:622
has only substance units: false
constant: false
type: Species

metaR O2tn
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
name: O2 nuclear transport
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false

metaM gthrd e
type: Species
is: CHEBI:57925
is: SBO:0000247
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
constant: false
initial concentration: 1.0
name: glutathionate(1-)
has only substance units: false
boundary condition: false

metaR SERDGLYexR
is described by: ECO:0000304
reversible: true
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110029#
type: Reaction
name: D-Serine/Glycine reversible exchange
is: SBO:0000185
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_04be45a8_4bcc_4fb7_a656_ab6eac06930d
name: _AI926493_1_m
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:AI926493
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_3171a470_8f1e_4f09_82b3_6331cb9997f2
name: EGFL8
initial amount: NaN
boundary condition: true
constant: false
is: Q99944
type: Species
is encoded by: hsa:80864
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR SBTR
name: D-sorbitol reductase
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110029#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction

metaR RE1796M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
modifier: MODEL1310110029#
name: RE1796

http://identifiers.org/biomodels.db/MODEL1310110029#_126b6bfb_509a_4d34_891a_84917937550e
initial amount: NaN
has only substance units: false
is encoded by: hsa:4709
is: SBO:0000252
name: NDUFB3
type: Species
boundary condition: true
initial concentration: NaN
is: Q6IB80
constant: false

metaR r2030
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR r1622
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_06edf266_8a95_4dfe_b420_4b94c5de31c8
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:4846
name: NOS3
is: A0S0A7
initial concentration: NaN
is: SBO:0000252

metaM chsterol l
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00067
name: cholesterol
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

http://identifiers.org/biomodels.db/MODEL1310110029#_f1bee1d4_73d1_4456_b144_45341b08c107
name: SYNJ2
type: Species
is encoded by: hsa:8871
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: O15056

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM rnam c
is: CHEBI:15927
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
boundary condition: false
type: Species
initial concentration: 1.0
name: N-Ribosylnicotinamide
is: HMDB00855
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaM leuktrB4 c
name: leukotriene B4(1-)
type: Species
is: CHEBI:57461
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
is: HMDB01085
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6fbf11b6_fb16_4650_b62b_9ddc51fffba9
name: NME1:NME2
boundary condition: true
is: SBO:0000297
initial amount: NaN
has part: P15531
initial concentration: NaN
is encoded by: hsa:4831
has only substance units: false
constant: false
is encoded by: hsa:4830
type: Species
has part: P22392

http://identifiers.org/biomodels.db/MODEL1310110029#_f0d76ea5_ee21_4bb1_adad_7b595b17ee4e
is: F8VQS7
constant: false
is: SBO:0000252
name: NDUFA12
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:55967
has only substance units: false

metaR r2099
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR r1901
reactant: MODEL1310110029#
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
is described by: ECO:0000000
reversible: false
is: SBO:0000185

metaM chsterol m
has only substance units: false
is: CHEBI:16113
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
name: cholesterol
initial amount: NaN
boundary condition: false
constant: false

metaR r0860
name: Utilized transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false

metaR r1621
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000000

metaM lnlccoa m
type: Species
name: linoleic coenzyme A
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_59d645fc_6d4f_4ec1_95d0_7a9c4f1d5dab
is: SBO:0000252
is encoded by: hsa:79966
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q86SK9
name: SCD5
constant: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM arg L c
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
initial amount: NaN
is: CHEBI:32682
type: Species
constant: false
is: HMDB00517
has only substance units: false
initial concentration: 1.0
name: L-argininium(1+)
boundary condition: false

metaM prpp e
initial amount: NaN
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e53cd527_346e_4130_b6ae_966377afc40e
name: UCK2
is encoded by: hsa:7371
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9BZX2

metaR G6PDH2rer
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum

metaR RETNt
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
name: retinoic acid transport
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT

metaR MCLACCYSR
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reactant: MODEL1310110029#
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
reversible: false

metaM HC00342 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:16383
is: SBO:0000247
constant: false
name: cis-aconitate(3-)
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaR RPEc
fast: false
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR FUMSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
name: Fumarate:sulfate antiport, mitochondrial
reversible: true
modifier: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_dd05209d_7416_4cb0_ba67_ce137562dcdb
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q16774
initial amount: NaN
is encoded by: hsa:2987
is: SBO:0000252
name: GUK1

metaM CE2432 m
is: C01936
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: SBO:0000247
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
type: Species
initial amount: NaN

metaM Rtotal3coa c
initial concentration: 1.0
name: R total 3 Coenzyme A
type: Species
initial amount: NaN
constant: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
is: CHEBI:16349
is: HMDB00904
boundary condition: false

metaR r1162
kinetic law: MODEL1310110029#
type: Reaction
reversible: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
name: Active transport
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR r1624
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_65754757_1de3_46e7_bc4a_f4b4a3e35043
is: Q53H96
initial concentration: NaN
is encoded by: hsa:65263
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: PYCRL
has only substance units: false
constant: false

metaM gchola c
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: CHEBI:58235
boundary condition: false
is: SBO:0000247
name: glycocholate
is: HMDB00138
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM leuktrB4 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
type: Species
is: HMDB01085
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: leukotriene B4(1-)
boundary condition: false

metaM b2coa m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:57332
name: crotonoyl-CoA(4-)
is: HMDB02009

metaM tcynt c
has only substance units: false
is: SBO:0000247
boundary condition: false
name: thiocyanate
is: CHEBI:18022
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
is: HMDB01453
initial concentration: 1.0
initial amount: NaN

metaM gthox m
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:58297
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

http://identifiers.org/biomodels.db/MODEL1310110029#_087c8581_6342_4522_885c_99a71d42b7a8
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA526438
initial amount: NaN
name: _AA526438_1_m
boundary condition: true
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR PYRt2m
type: Reaction
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
reversible: true
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
product: MODEL1310110029#

metaR r1623
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true

metaR GLYCtm
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: glycerol transport
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_3c55b839_404b_4af6_b51c_c12abb044df5
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: F8WDN9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27068
name: PPA2

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
name: Transport of L-malate
kinetic law: MODEL1310110029#
is: SBO:0000185

metaR r0679
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#

metaM xol25oh r
has only substance units: false
type: Species
is: HMDB06247
is: CHEBI:42977
name: 25-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b3426bc5_8aa6_43c2_bb5b_bfbcb2013a1a
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: _H53099_1_m
initial amount: NaN
is encoded by: hsa:H53099

metaR HYXNt
kinetic law: MODEL1310110029#
is described by: ECO:0000269
name: Hypoxanthine transport
is: SBO:0000185
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv

metaR ARACHDCOAtx
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#

metaM ala D e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01310
constant: false
is: SBO:0000247
is: CHEBI:15570

metaR LEUPHELAT2tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM arg L e
name: L-argininium(1+)
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:32682
constant: false
is: HMDB00517
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_588f8d85_b7e6_41aa_85f3_64ed013bb23d
constant: false
initial concentration: NaN
name: COX7A2
has only substance units: false
is encoded by: hsa:1347
initial amount: NaN
boundary condition: true
is: H0UI06
is: SBO:0000252
type: Species

metaR r1088
is described by: ECO:0000000
name: Active transport
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM tcynt e
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:18022
name: thiocyanate
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: HMDB01453
has only substance units: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM L2aadp c
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
is: CHEBI:58672
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00510
name: L-2-aminoadipate(1-)
constant: false

metaR 3SPYRSP
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
reactant: MODEL1310110029#

metaR BPNT
is version of: http://identifiers.org/ec-code/3.1.3.7
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reversible: false
product: MODEL1310110029#
name: 3',5'-bisphosphate nucleotidase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_93c4993c_344e_4495_811a_8ce34ac376a0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O00476
type: Species
constant: false
has only substance units: false
name: SLC17A3
boundary condition: true
is encoded by: hsa:10786

http://identifiers.org/biomodels.db/MODEL1310110029#_8199c359_d512_4d93_80c7_1a13fcee7056
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC5A3
is encoded by: hsa:6526
constant: false
is: P53794
has only substance units: false
initial concentration: NaN
type: Species

metaM ach n
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00895
is: CHEBI:15355
name: acetylcholine

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
product: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM k c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00586
is: CHEBI:29103
name: potassium
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaM pheme c
constant: false
is: SBO:0000247
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
type: Species
initial amount: NaN
is: HMDB03178
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Protoheme
is: CHEBI:17627

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: CHEBI:58190
initial amount: NaN
type: Species
name: ethamp[c]
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00224
has only substance units: false
is: SBO:0000247

metaR MTHFD2m
is: SBO:0000176
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
reactant: MODEL1310110029#
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_712dbbb2_e361_4f98_a115_91e9757f4a46
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:3418
name: IDH2
is: P48735
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR PHCHGSm
product: MODEL1310110029#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_19a647d3_a6c0_4898_8303_f275478dae15
type: Species
boundary condition: true
is encoded by: hsa:51102
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9BV79
has only substance units: false
name: MECR
constant: false

metaM etoh c
initial concentration: 1.0
constant: false
has only substance units: false
name: ethanol
is: SBO:0000247
is: HMDB00108
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
boundary condition: false
initial amount: NaN
type: Species

metaR DNDPt26m
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000269
name: dCDP transport via dUDP antiport
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110029#

metaR LNLCt
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110029#
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_e959d51e_dd30_440f_8cff_18af5b18537a
name: _AA278423_1_c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AA278423
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

metaM lys L e
name: L-lysinium(1+)
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:32551
is: SBO:0000247
type: Species
is: HMDB00182
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_0cde3556_4718_4b0d_a34a_8cdc2eb9aa8f
initial concentration: NaN
is encoded by: hsa:1375
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: CPT1B
constant: false
has only substance units: false
is: Q92523

metaM xol7aone r
is: CHEBI:17899
is: HMDB01993
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaR PPItm
name: diphopshate transporter, mitochondrial
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.

http://identifiers.org/biomodels.db/MODEL1310110029#_077e34e4_5b0b_4ed5_844e_83e906e7acec
is: SBO:0000252
constant: false
initial concentration: NaN
is: P42765
type: Species
has only substance units: false
is encoded by: hsa:10449
boundary condition: true
name: ACAA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_1f7a439f_db95_43c5_a485_3267521e0729
has only substance units: false
type: Species
name: _H17063_1_c
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:H17063

http://identifiers.org/biomodels.db/MODEL1310110029#_15a270eb_edde_40d7_91d5_03646226d8b0
initial concentration: NaN
is: SBO:0000252
is: Q96Q11
type: Species
has only substance units: false
name: TRNT1
initial amount: NaN
is encoded by: hsa:51095
constant: false
boundary condition: true

metaM dolp L r
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57683
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_c0452f2e_4e8b_4edc_ace2_de8692d58709
type: Species
name: ELOVL2
initial concentration: NaN
boundary condition: true
is: Q9NXB9
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:54898
has only substance units: false

metaM 56dthm c
name: 5,6-dihydrothymine
has only substance units: false
is: HMDB00079
constant: false
is: CHEBI:27468
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6a456cb7_ce7b_4ddf_9282_e056549397ec
boundary condition: true
initial concentration: NaN
is: Q9NPB1
constant: false
is encoded by: hsa:56953
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NT5M

metaR r1497
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
fast: false
product: MODEL1310110029#
reversible: false
is: SBO:0000185

metaR r0523
reversible: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false

metaR ALAGLYexR
reversible: true
fast: false
product: MODEL1310110029#
is described by: ECO:0000304
kinetic law: MODEL1310110029#
name: L-alanine/glycine reversible exchange
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM g6p r
is: HMDB01401
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: D-Glucose 6-phosphate
boundary condition: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
constant: false
is: CHEBI:61548

http://identifiers.org/biomodels.db/MODEL1310110029#_2cc2a081_b4d1_459e_8316_269c2817e74b
type: Species
name: ACAA2
constant: false
is: SBO:0000252
is encoded by: hsa:10449
initial amount: NaN
is: P42765
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR PPD2CSPp
type: Reaction
name: PPD2CSPp
fast: false
reactant: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#

metaM lnlccoa c
is: HMDB01064
type: Species
name: linoleic coenzyme A
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_eeadf8a8_bded_4c1f_bc41_076fab9b9a6c
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: P08319
name: ADH4
initial concentration: NaN
is encoded by: hsa:127
type: Species

metaM HC01403 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaM 3hmbcoa m
boundary condition: false
is: CHEBI:57312
is: HMDB01356
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405

metaR r0149
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#

metaR CMPSAS
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
name: CMP sialic acid synthase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_fd7f2a7c_1049_44c4_a972_01d0ed317916
has only substance units: false
name: SLC4A10
initial concentration: NaN
initial amount: NaN
is: B7Z1R0
is encoded by: hsa:57282
is: SBO:0000252
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0bdd08ca_b12e_4f3a_b3ae_07b48fd33847
initial concentration: NaN
type: Species
is: SBO:0000252
is: P05187
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:250
initial amount: NaN
name: ALPP

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: HMDB01113
is: SBO:0000247
name: Isovaleryl-CoA
boundary condition: false
is: CHEBI:57345
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

metaR 3HBCOAHLm
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
reversible: false

metaM oxa m
is: CHEBI:30623
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
name: oxalate(2-)
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02329
is: SBO:0000247

metaR PI345P3Pn
is: SBO:0000176
reversible: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, nuclear
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863,PMID:12728269 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.67
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d874467f_6b0f_488f_9bb0_dcd486bc1ace
is: Q9UPY5
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC7A11
is encoded by: hsa:23657
initial concentration: NaN
constant: false

metaR FACOAL181i
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
name: C181 fatty acid activation
fast: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaR r1499
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110029#
reversible: false
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_4822ea4f_d318_4910_be91_cd38feba2555
is: O75438
is encoded by: hsa:4707
type: Species
name: NDUFB1
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM hom L e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15699
name: L-homoserine
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719

metaM gthrd m
is: CHEBI:57925
name: glutathionate(1-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00125
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

http://identifiers.org/biomodels.db/MODEL1310110029#_f121267a_0cd3_41b3_8146_b4016adf9171
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:55825
is: Q9BY49
name: PECR

metaR HDCAter
fast: false
type: Reaction
product: MODEL1310110029#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
name: palmitate ER export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR NOt
reactant: MODEL1310110029#
is described by: ECO:0000000
name: NO transport (diffusion)
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
fast: false
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_fa7fe89e_ca07_46e1_9bad_f43f2c72ecdc
type: Species
boundary condition: true
initial concentration: NaN
name: _AL038231_1_c
initial amount: NaN
constant: false
is encoded by: hsa:AL038231
has only substance units: false
is: SBO:0000252

metaR PUNP3
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: purine-nucleoside phosphorylase (Guanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110029#
fast: false
reversible: true
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
is: SBO:0000176

metaR r1629
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACOX22x
kinetic law: MODEL1310110029#
name: acyl-Coenzyme A oxidase 2, branched chain
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is version of: http://identifiers.org/ec-code/1.17.99.3
fast: false
product: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110029#
is described by: ECO:0000304

metaM pro D e
is: CHEBI:16313
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB03411
initial concentration: 1.0
is: SBO:0000247
name: D-proline

metaR PAIL4P HStn
reversible: true
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR O2tp
name: O2 transport, peroxisomal
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185

metaR PA HStg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
reversible: true
name: phosphatidate scramblase
is: SBO:0000185
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_12a9ce95_6904_442b_8d8c_749e7ff957e1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55825
is: Q9BY49
name: PECR
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_1d668f08_81db_48e1_96e4_4f0cf3a85752
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:221
is: P43353
name: ALDH3B1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_94d13595_6294_4343_9f24_e1a51a2d7e51
name: FECH
is encoded by: hsa:2235
type: Species
is: SBO:0000252
is: Q7KZA3
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
modifier: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269

metaR r1516
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reversible: false
reactant: MODEL1310110029#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
fast: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM chsterol r
is: HMDB00067
boundary condition: false
name: cholesterol
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR r0527
type: Reaction
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_8c8439ca_1ad1_449e_8e14_bbfbb8315ed5
is encoded by: hsa:30833
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NT5C
initial concentration: NaN
is: Q8TCD5
has only substance units: false
type: Species
constant: false

metaM fum c
is: SBO:0000247
name: Fumarate
is: CHEBI:29806
is: HMDB00134
is: C00122
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
has only substance units: false
type: Species

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ca1f8e84_5b50_4b99_b45c_6c4cb8380561
initial concentration: NaN
is encoded by: hsa:4708
is: H7C5B8
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFB2
constant: false
has only substance units: false
type: Species

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_b81e50a8_459b_4ac5_aac5_eb1c37a62cde
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r1418
is: SBO:0000176
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110029#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000

metaM hom L c
is: CHEBI:15699
type: Species
is: HMDB00719
name: L-homoserine
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM arg L m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
boundary condition: false
name: L-argininium(1+)
initial amount: NaN
is: CHEBI:32682
constant: false
type: Species

metaR r2379
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110029#

metaR DURItn
name: deoxyuridine transport in nucleus
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110029#_f429a217_eae2_4181_9b75_abb44e6f5b95
is encoded by: hsa:10935
has only substance units: false
name: PRDX3
is: SBO:0000252
is: E9PH29
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_c973c35f_7c27_4c44_825b_353edc5aa406
is encoded by: hsa:AI924226
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: _AI924226_1_m
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_d67d443a_0b4b_465c_b00e_3e1ec44ea988
is: P48775
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6999
name: TDO2
initial concentration: NaN

metaR HIBDm
is: SBO:0000176
modifier: MODEL1310110029#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is described by: ECO:0000269
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.31
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction

metaM pro D c
is: SBO:0000247
is: CHEBI:16313
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: D-proline
is: HMDB03411

metaM phe L c
has only substance units: false
name: L-phenylalanine
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
is: CHEBI:17295
is: SBO:0000247
constant: false
is: HMDB00159
initial amount: NaN
initial concentration: 1.0

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR HGNTOR
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110029#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reactant: MODEL1310110029#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.5
product: MODEL1310110029#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction

metaM etoh e
type: Species
initial concentration: 1.0
constant: false
name: ethanol
is: CHEBI:16236
is: HMDB00108
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: SBO:0000247
has only substance units: false

metaM HC00342 c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:16383
constant: false
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false

metaM lys L c
is: SBO:0000247
has only substance units: false
is: HMDB00182
is: CHEBI:32551
boundary condition: false
initial amount: NaN
name: L-lysinium(1+)
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_78d13cad_8d7a_4b5f_9751_e08aa712a3c3
name: NDUFV3
has only substance units: false
constant: false
is: P56181
initial amount: NaN
type: Species
is encoded by: hsa:4731
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_91c3913b_359e_4651_b1c6_55415e0ca082
name: _AI971036_1_x
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI971036
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM occoa c
initial amount: NaN
is: CHEBI:57386
initial concentration: 1.0
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: HMDB01070
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR r2378
is described by: ECO:0000000
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
fast: false

metaR HDCAtr
reversible: true
name: fatty acid transport via diffusion
type: Reaction
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110029#

metaR SPODM
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction
name: superoxide dismutase
reversible: false
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM dutp n
constant: false
type: Species
boundary condition: false
is: HMDB01191
is: CHEBI:17625
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
has only substance units: false
name: dUTP
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_aff77c59_fb4c_4f40_b1d6_9ead91f20f95
is: P14550
constant: false
name: AKR1A1
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10327
is: SBO:0000252

metaM 10fthf c
boundary condition: false
is: SBO:0000247
is: HMDB00972
type: Species
has only substance units: false
is: CHEBI:57454
name: 10-Formyltetrahydrofolate
is: C00234
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
constant: false

metaR SUCCt2m
product: MODEL1310110029#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
kinetic law: MODEL1310110029#
name: succinate transport, mitochondrial
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4c604d3d_bf6e_43e5_b19b_b6151ff0f02e
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8WUX1
initial amount: NaN
name: SLC38A5
type: Species
initial concentration: NaN
is encoded by: hsa:92745
constant: false

metaR DOLGLCP Lter
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
reversible: false
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
product: MODEL1310110029#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR DOLGPP Ler
kinetic law: MODEL1310110029#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaM HC00591 c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: 2-oxoglutaramate
is: CHEBI:16769

http://identifiers.org/biomodels.db/MODEL1310110029#_e5864842_2777_43e8_b48c_6552993d11f9
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: DPYD
constant: false
has only substance units: false
is encoded by: hsa:1806
is: SBO:0000252
is: Q12882
type: Species

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM dutp m
is: CHEBI:17625
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
type: Species
name: dUTP
is: HMDB01191
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM hdca e
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C16H31O2 CHARGE: -1
is: HMDB00220
type: Species
is: C00249
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: Hexadecanoate (n-C16:0)

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18407
constant: false
has only substance units: false
name: hydrogen cyanide
initial concentration: 1.0
is: HMDB02084

http://identifiers.org/biomodels.db/MODEL1310110029#_ff9ffe81_1b21_466a_9e95_092bced0a0df
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CHAT
is encoded by: hsa:1103
boundary condition: true
is: Q6LEN6
initial concentration: NaN
type: Species

metaM HC02204 c
is: CHEBI:27624
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
initial amount: NaN
name: prostaglandin-b1
type: Species

metaM orot c
is: CHEBI:30839
type: Species
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00226
name: Orotate
constant: false
is: C00295
initial concentration: 1.0

metaM udp e
initial amount: NaN
constant: false
boundary condition: false
name: UDP(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
has only substance units: false

metaM ctp n
name: CTP(4-)
type: Species
is: CHEBI:37563
has only substance units: false
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_67b0d17a_2c02_4bad_a2c0_83f00aa83345
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:51727
name: CMPK1
type: Species
has only substance units: false
is: B2R6S5
initial concentration: NaN

metaM ttdca c
is: CHEBI:30807
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00806
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
constant: false
has only substance units: false
name: myristate

metaR 1PPDCRp
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110029#_f84025f7_1469_4883_80ec_92c83a15dee1
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: DPYS
is encoded by: hsa:1807
constant: false
has only substance units: false
is: Q14117
initial concentration: NaN

metaR MMTSADm
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is: SBO:0000176
product: MODEL1310110029#
reversible: false
type: Reaction

metaR CYTK6n
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
name: cytidylate kinase (CMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_afb39195_94de_49b8_acb6_d384afa0849f
name: PRDX3
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: P30048
has only substance units: false
is encoded by: hsa:10935
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_de2f9137_08a0_4b4f_ae72_b909a3a56ec6
boundary condition: true
is: B3KVA3
constant: false
is encoded by: hsa:112724
initial amount: NaN
name: RDH13
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_dfad55a5_cbfe_4fb6_a60e_8d78666bbc1b
initial concentration: NaN
is encoded by: hsa:37
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: P49748
has only substance units: false
name: ACADVL
type: Species

metaM methf m
is: CHEBI:57455
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false
is: HMDB01354
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
name: (6R)-5,10-methenyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110029#_ea862978_bb96_487b_800f_c7783d84296a
type: Species
is encoded by: hsa:4709
is: SBO:0000252
has only substance units: false
constant: false
is: Q6IB80
initial amount: NaN
initial concentration: NaN
name: NDUFB3
boundary condition: true

metaM ppi x
boundary condition: false
type: Species
is: C00013
is: HMDB00250
constant: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019
name: Diphosphate
is: SBO:0000247
has only substance units: false

metaM prostge2 c
name: prostaglandin E2(1-)
initial amount: NaN
boundary condition: false
is: CHEBI:606564
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01220
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

http://identifiers.org/biomodels.db/MODEL1310110029#_af7648a0_c7f1_4b38_bcc0_680a57895f0f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:441024
initial amount: NaN
boundary condition: true
name: MTHFD2L
constant: false
is: Q9H903
type: Species
initial concentration: NaN

metaM dgdp n
type: Species
is: CHEBI:58595
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
name: dGDP(2-)
is: HMDB00960
initial amount: NaN

metaR r1591
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true

metaR FRDPtcr
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_023c18ec_ad48_4e1b_a3bc_49e286a13f5a
constant: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
type: Species
has part: Q5VYT2
has only substance units: false
is encoded by: hsa:4712
is encoded by: hsa:4731
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN

metaM cyan e
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
type: Species
is: HMDB02084
initial concentration: 1.0
name: hydrogen cyanide
constant: false

metaR ILETAm
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110029#
fast: false
type: Reaction
name: isoleucine transaminase, mitochondrial
reversible: true
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaM vitd3 c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: HMDB00876
constant: false
is: CHEBI:28940
initial amount: NaN
has only substance units: false
name: calciol
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_2bc38c2c_d348_4870_9b91_7a1ea34b73ab
has only substance units: false
constant: false
name: FOLR1
boundary condition: true
type: Species
is encoded by: hsa:2348
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_ef40f459_a2a7_4d01_9453_2bc2fe5fed0e
is encoded by: hsa:4713
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: P17568
type: Species
name: NDUFB7

metaR r0541
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
reactant: MODEL1310110029#
fast: false
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
modifier: MODEL1310110029#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM HC02204 e
is: SBO:0000247
constant: false
is: CHEBI:27624
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
type: Species
name: prostaglandin-b1

metaM udp g
initial concentration: 1.0
has only substance units: false
is: HMDB00295
constant: false
is: CHEBI:58223
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR PROt2r
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110029#
reversible: true
is described by: ECO:0000304
name: L-proline reversible transport via proton symport
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM orot e
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
name: orotate
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:30839
type: Species
has only substance units: false
is: HMDB00226
is: SBO:0000247
initial concentration: 1.0

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
name: O2 transport, endoplasmic reticulum

metaM dgdp m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
type: Species
is: HMDB00960
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58595
name: dGDP(2-)

http://identifiers.org/biomodels.db/MODEL1310110029#_6af6f3c0_0456_4de8_8700_54d7680578be
is: SBO:0000252
is: P35790
initial amount: NaN
name: CHKA
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1119
type: Species

metaM ttdca e
initial amount: NaN
is: HMDB00806
is: SBO:0000247
type: Species
constant: false
name: tetradecanoate (n-C14:0)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
has only substance units: false
is: C06424
is: CHEBI:30807

metaR r1590
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#

metaM pnto R c
is: CHEBI:7916
initial concentration: 1.0
name: (R)-Pantothenate
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
is: HMDB00210
boundary condition: false

metaM CE0849 m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
boundary condition: false
is: C01936
constant: false
has only substance units: false

metaM ser D e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03406
constant: false
name: D-serine
initial amount: NaN
is: CHEBI:16523
type: Species

metaR r2420
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110029#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7

http://identifiers.org/biomodels.db/MODEL1310110029#_8258134a_85e3_427d_83ab_ebbf5e15a7ac
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: ESCO1
is encoded by: hsa:114799
boundary condition: true
is: Q5FWF5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_c3781573_89a4_42d8_9235_48f5f55a8bee
is: P09848
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3938
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: LCT

metaM glyc R c
is: CHEBI:16659
constant: false
type: Species
boundary condition: false
name: D-glycerate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247

metaM dhf m
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01056
name: dihydrofolate(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57451
is: SBO:0000247
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110029#_979ea61d_ee6d_4f8a_a126_56beb96a75f0
name: NT5C1B
is: Q96P26
is encoded by: hsa:93034
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_8ca9b10a_0e1b_4d6b_9cc4_73c94f4a058f
initial amount: NaN
type: Species
is encoded by: hsa:10993
name: SDS
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P20132
boundary condition: true
constant: false

metaR r0355
is: SBO:0000176
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110029#

metaR r1720
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_56f60965_992d_4479_8524_c1791a2f9151
is: P21108
name: PRPS1L1
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:221823

http://identifiers.org/biomodels.db/MODEL1310110029#_56591771_0e11_48d8_992f_01081bae0ad3
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI972237
name: _AI972237_1_c
has only substance units: false
is: SBO:0000252
type: Species

metaR BUTt2r
reversible: true
modifier: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Butyrate transport via proton symport, reversible
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is described by: ECO:0000269

metaR 13DAMPPOX
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
is described by: ECO:0000212
reversible: false

metaM dag hs e
type: Species
is: CHEBI:18035
initial amount: NaN
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: diglyceride
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR VD3
is: SBO:0000176
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
kinetic law: MODEL1310110029#
is described by: ECO:0000134
name: Vitamin D3 formation
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110029#

metaR NODe
reversible: true
name: NODe
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_7fd0f712_c173_4456_ba86_e96e3e9f49e2
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P36021
is encoded by: hsa:6567
boundary condition: true
name: SLC16A2
has only substance units: false
is: SBO:0000252

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_62d786e8_d662_424b_b105_bf83764ac6d8
type: Species
is encoded by: hsa:8525
is: B7Z6M3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: DGKZ
constant: false
initial amount: NaN

metaR r1660
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
type: Reaction

metaR RE1520M
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: RE1520
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1721
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE3556C
is: SBO:0000176
product: MODEL1310110029#
name: RE3556
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM pnto R e
is: SBO:0000247
is: CHEBI:7916
constant: false
name: (R)-Pantothenate
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
initial concentration: 1.0

metaR r0354
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2a9888d9_09bd_4f45_83b2_bdd386f35d07
name: FASN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: P49327
is encoded by: hsa:2194
boundary condition: true
initial amount: NaN

metaR UMPK
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110029#
name: UMP kinase
is: SBO:0000176
modifier: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM gudac c
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:16344
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
name: guanidinoacetic acid
initial concentration: 1.0
is: HMDB00128
constant: false

metaR Q10H2e
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
fast: false
name: transport of ubiquinol into lymph
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110029#

metaR G3PD1
type: Reaction
name: glycerol-3-phosphate dehydrogenase (NAD)
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
modifier: MODEL1310110029#
fast: false
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000269

metaM phe L e
is: HMDB00159
initial amount: NaN
has only substance units: false
name: L-phenylalanine
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295

http://identifiers.org/biomodels.db/MODEL1310110029#_cadef780_ebda_4960_9d19_6ccb38b2b056
type: Species
initial amount: NaN
is encoded by: hsa:5337
name: PLD1
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q59EA4

metaM CE5786 e
is: HMDB02710
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
type: Species
constant: false
boundary condition: false
is: CHEBI:27485
name: kinetensin
is: SBO:0000247

metaM 34dhmald m
is: HMDB06242
initial concentration: 1.0
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7903
is: C05577
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9cb80e79_0652_4eb0_b3e0_3bd972d633dc
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: UGT1A1
is: SBO:0000252
is: P22309
is encoded by: hsa:54658
constant: false

metaR 2AMADPTm
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110029#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM 6pgc r
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: SBO:0000247
is: CHEBI:58759
initial concentration: 1.0
name: 6-phosphonatooxy-D-gluconate
is: HMDB01316
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR PSSA2 hs
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
name: Phosphatidylserine synthase homo sapiens
is version of: http://identifiers.org/ec-code/2.7.8.29
is described by: ECO:0000269
fast: false
product: MODEL1310110029#

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase
kinetic law: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is described by: ECO:0000269
reversible: true

metaM abt c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
name: L-arabinitol
boundary condition: false
initial amount: NaN
is: CHEBI:18403
type: Species

metaM hdca c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
is: CHEBI:7896
boundary condition: false
is: HMDB00220
is: SBO:0000247
name: palmitate
type: Species

metaR AK2LGCHOLt
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
is described by: ECO:0000269
product: MODEL1310110029#

metaR ILEt5m
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Isoleucine mitochondrial transport
reversible: true
type: Reaction

metaM dag hs c
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:18035

metaR HMGLm
fast: false
name: hydroxymethylglutaryl-CoA lyase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reversible: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000134
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.1.3.4

metaM 34dhoxmand c
initial concentration: 1.0
is: CHEBI:27637
is: HMDB01866
is: SBO:0000247
initial amount: NaN
name: 3,4-Dihydroxymandelate
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_54321cb6_b1b9_4b16_98ae_126ada500da6
is: P53004
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:644
name: BLVRA

http://identifiers.org/biomodels.db/MODEL1310110029#_9181dca7_6280_40e4_ab3c_7eaf93d2f842
name: COX7B
constant: false
is encoded by: hsa:1349
boundary condition: true
is: P24311
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR CLHCO3tex2
modifier: MODEL1310110029#
name: chloride transport via bicarbonate countertransport (2:1)
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
reversible: false
type: Reaction
is described by: ECO:0000304

metaR r2341
product: MODEL1310110029#
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_15328444_f61b_4031_aeea_f584df411025
initial concentration: NaN
boundary condition: true
name: UCK2
is: Q9BZX2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7371

metaR r0202
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
product: MODEL1310110029#

metaM dhap x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
has only substance units: false
constant: false
is: C00111
initial concentration: 1.0
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: CHEBI:57642
type: Species
initial amount: NaN

metaM CE5121 m
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
name: trans-3-decenoyl-CoA
is: CHEBI:57449
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial concentration: 1.0
has only substance units: false

metaR 4MOPt2im
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110029#_aa844bec_45c1_46b1_b5a3_cc5a87adde45
is encoded by: hsa:7264
name: TSTA3
is: Q13630
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM chsterol c
constant: false
initial amount: NaN
boundary condition: false
name: cholesterol
initial concentration: 1.0
is: CHEBI:16113
has only substance units: false
is: SBO:0000247
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a7878dfc_a868_46b0_aa70_672be3481ccc
boundary condition: true
initial amount: NaN
is encoded by: hsa:27034
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACAD8
is: Q6ZWP6
type: Species
has only substance units: false

metaM glyc c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17754
boundary condition: false
name: Glycerol
is: C00116
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
constant: false
has only substance units: false
is: SBO:0000247

metaM ac e
is: HMDB00042
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:30089
initial amount: NaN

metaR r2092
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#

metaM ppi r
is: HMDB00250
boundary condition: false
name: Diphosphate
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:33019
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110029#_eeaf465c_d98d_404f_bfa9_9ec73de0bb8b
name: TM7SF2
constant: false
initial amount: NaN
is: O76062
is encoded by: hsa:7108
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaM methf c
is: C00445
is: CHEBI:57455
type: Species
name: 5,10-Methenyltetrahydrofolate
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
initial concentration: 1.0
is: HMDB01354
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_16edf5c8_3d20_4a96_aeda_51d04520f20a
is encoded by: hsa:570
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q14032
is: SBO:0000252
boundary condition: true
name: BAAT

metaM 10fthf m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
type: Species
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
has only substance units: false

metaR r1664
is described by: ECO:0000000
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NH4tp
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: ammonia peroxisomal transport
product: MODEL1310110029#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM gluside hs r
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18368
has only substance units: false
initial amount: NaN

metaR KCC2t
kinetic law: MODEL1310110029#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_4c66e699_d58e_4407_ba24_cfc1ad118abd
is: Q9BZW2
constant: false
is encoded by: hsa:6561
has only substance units: false
type: Species
is: SBO:0000252
name: SLC13A1
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM abt e
name: L-arabinitol
constant: false
is: HMDB01851
is: CHEBI:18403
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false

metaR r2093
kinetic law: MODEL1310110029#
type: Reaction
fast: false
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is: SBO:0000185

metaR H2Otly
name: H2O transport, lysosomal
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR RE3520E
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110029#
name: RE3520
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d3f7e5af_6e46_47c3_bc4f_222ef1b9991c
initial concentration: NaN
name: RPIA
constant: false
is encoded by: hsa:22934
is: P49247
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1661
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_ec9e7d45_561d_4798_a8ab_240d2515b315
boundary condition: true
initial concentration: NaN
name: EHHADH
initial amount: NaN
constant: false
is encoded by: hsa:1962
is: Q9NY65
is: SBO:0000252
type: Species
has only substance units: false

metaR r2497
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR GALU
fast: false
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#

metaM chsterol e
initial amount: NaN
name: cholesterol
is: HMDB00067
has only substance units: false
type: Species
constant: false
is: CHEBI:16113
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
boundary condition: false

metaM ac c
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:30089
name: acetate
initial amount: NaN

metaR CTPtn
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true
name: CTP diffusion in nucleus
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR RETI1
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110029#
name: retinol isomerase (11-cis)
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
reversible: true

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
fast: false
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_082d47e6_a379_49ce_b2a6_a659018ce678
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:222
initial concentration: NaN
is: SBO:0000252
is: P48448
name: ALDH3B2
initial amount: NaN
type: Species

metaM ocdcea e
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00207
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
is: CHEBI:0
constant: false

metaM oxa x
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
is: CHEBI:30623
boundary condition: false
is: HMDB02329
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_388fe4f5_e21a_4e55_b2f7_aef0c3c531ce
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: LDHC
type: Species
is: SBO:0000252
is encoded by: hsa:3948

metaR NH4tn
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: ammonia nuclear transport
kinetic law: MODEL1310110029#

metaR r1156
kinetic law: MODEL1310110029#
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
reversible: true
is: SBO:0000176

metaM CE2705 c
name: quinonoid dihydrobiopterin
initial amount: NaN
is: CHEBI:36781
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1662
fast: false
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#

metaM 1p3h5c m
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: SBO:0000247
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:6151
type: Species
initial concentration: 1.0

metaR r2091
kinetic law: MODEL1310110029#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110029#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#

metaR RETI2
is described by: ECO:0000000
name: retinol isomerase (9-cis)
reactant: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_7ce7b7c1_0780_4683_b5dc_2c0bf7eacc47
boundary condition: true
is: P47895
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: ALDH1A3
is: SBO:0000252
is encoded by: hsa:220
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_d498e006_ce11_460f_ba13_50e9415a255d
boundary condition: true
is: Q9NY65
initial concentration: NaN
is encoded by: hsa:1962
initial amount: NaN
name: EHHADH
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR MECOAS1m
reactant: MODEL1310110029#
is described by: ECO:0000304
fast: false
reversible: true
name: mesaconate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR RPI
modifier: MODEL1310110029#
is: SBO:0000176
name: ribose-5-phosphate isomerase
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/5.3.1.6
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a5161ef0_4772_4434_bcf4_88e4452db287
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1809
boundary condition: true
initial amount: NaN
is: Q8IXW6
constant: false
name: DPYSL3
type: Species

metaM spmd c
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01257
is: C00315
is: CHEBI:57834
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Spermidine

metaR MANt4
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110029#
product: MODEL1310110029#
name: D-mannose transport via sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110029#_c4bbda4c_5a3f_4ae4_a746_80a385debd69
name: PLCD4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84812
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q9BRC7
initial amount: NaN

metaR r2123
modifier: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM man e
is: C00159
initial amount: NaN
is: CHEBI:16024
initial concentration: 1.0
name: D-Mannose
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
is: SBO:0000247

metaM prostge2 e
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
initial amount: NaN
constant: false
type: Species
is: HMDB01220
is: CHEBI:606564
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM dolp L c
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
type: Species
is: CHEBI:57683
boundary condition: false
name: dolichyl phosphate(2-)
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR r0651
product: MODEL1310110029#
fast: false
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110029#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:

metaR r1667
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reversible: true
type: Reaction

metaM ocdcea c
type: Species
name: octadecenoate (n-C18:1)
is: HMDB00207
is: CHEBI:0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00712
constant: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_28170c91_8422_40b6_8dea_f1121c6fc557
name: LDHD
is: Q86WU2
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:197257
constant: false
type: Species

metaM ppi n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:33019
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
name: diphosphate(3-)
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110029#_b33beae4_a8de_4c47_a559_a28757f57bbd
name: PLCH1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: Q4KWH8
is encoded by: hsa:23007
initial concentration: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM pppg9 c
is: C01079
is: HMDB01097
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
boundary condition: false
is: CHEBI:57307
initial concentration: 1.0
constant: false
has only substance units: false
name: Protoporphyrinogen IX

metaM 2dr1p c
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58576
is: HMDB01351
name: 2-Deoxy-D-ribose 1-phosphate
is: C00672
boundary condition: false
has only substance units: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r2122
fast: false
modifier: MODEL1310110029#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#

metaM dgdp c
is: C00361
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
type: Species
is: CHEBI:58595
initial amount: NaN
constant: false
name: dGDP

http://identifiers.org/biomodels.db/MODEL1310110029#_75dd0683_e210_4ea1_8e03_69197e136640
name: _BC005314_1_x
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:BC005314
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_fa55efe5_2cdd_45d7_aa1e_ec28a02633b7
is encoded by: hsa:4715
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9Y6M9
name: NDUFB9
constant: false

metaR NH4t3r
name: ammonia transport via proton antiport
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reactant: MODEL1310110029#
fast: false
is: SBO:0000185
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_f7396f02_8ea9_4843_ad32_92c40415795d
has only substance units: false
name: PLCG2
is encoded by: hsa:5336
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: P16885
boundary condition: true

metaR RE3627M
reversible: true
name: RE3627
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110029#

metaR r1668
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_46ea6c46_93bb_41aa_a360_c8ff0019e482
initial concentration: NaN
boundary condition: true
type: Species
name: _W87865_1_c
has only substance units: false
constant: false
is encoded by: hsa:W87865
initial amount: NaN
is: SBO:0000252

metaR r0812
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
type: Reaction
product: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_641c8969_091e_40bd_a03b_ddfd97240e0a
has only substance units: false
is: Q9NUB1
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: ACSS1
is encoded by: hsa:84532

http://identifiers.org/biomodels.db/MODEL1310110029#_a579b428_27e0_4e55_9e02_12fca6307c98
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9197
initial concentration: NaN
name: SLC33A1
is: O00400
type: Species
initial amount: NaN
has only substance units: false

metaM ppi m
is: HMDB00250
initial amount: NaN
is: C00013
is: SBO:0000247
type: Species
is: CHEBI:33019
name: Diphosphate
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false

metaR r2121
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM ctp m
type: Species
is: SBO:0000247
is: HMDB00082
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: CTP(4-)
boundary condition: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR NDPK3m
reversible: true
is described by: ECO:0000254
kinetic law: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
type: Reaction
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110029#

metaR XOL27OHtm
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: true
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_8d1311d9_664c_496a_9e5b_192e89950bdf
initial concentration: NaN
is: O43677
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: NDUFC1
is encoded by: hsa:4717
boundary condition: true

metaM dhf c
type: Species
is: HMDB01056
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 7,8-Dihydrofolate
is: C00415

metaR UGCG
name: Ceramide glucosyltransferase
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80
is: SBO:0000176
reversible: false

metaR r1665
reversible: true
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
type: Reaction

metaM man c
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
name: D-Mannose
is: SBO:0000247
is: C00159
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
constant: false

metaR DNDPt9m
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is: SBO:0000185
reversible: false
modifier: MODEL1310110029#
name: dADP transport via dTDP antiport
kinetic law: MODEL1310110029#
is described by: ECO:0000269

metaM f6p c
is: C00085
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57579
has only substance units: false
boundary condition: false
name: D-Fructose 6-phosphate
constant: false
is: HMDB00124

http://identifiers.org/biomodels.db/MODEL1310110029#_2cfabb59_094b_45ae_b4dc_3664e3bb575c
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: O75438
is encoded by: hsa:4707
name: NDUFB1
type: Species
has only substance units: false

metaR AICARte
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
reversible: true
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000134
fast: false

metaM 12ppd S c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB06213
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
has only substance units: false
name: (S)-propane-1,2-diol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_3aedb610_f3a7_4a9c_ab7f_437f87c9e33b
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ACAT1
is: P24752

http://identifiers.org/biomodels.db/MODEL1310110029#_5e51cc3b_d9e9_42b2_a0ba_fedcf6de0680
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P11586
is encoded by: hsa:4522
type: Species
boundary condition: true
has only substance units: false
name: MTHFD1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d8f724c7_263b_49fc_a10e_b0673149352a
type: Species
initial amount: NaN
is encoded by: hsa:400410
initial concentration: NaN
has only substance units: false
name: ST20
boundary condition: true
is: SBO:0000252
constant: false
is: Q9HBF5

http://identifiers.org/biomodels.db/MODEL1310110029#_457abd7c_d90f_48c0_b055_bc9f3fad688c
is: SBO:0000252
boundary condition: true
constant: false
is: B2RD24
type: Species
name: MTHFD1L
initial concentration: NaN
has only substance units: false
is encoded by: hsa:25902
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_17caeb5f_40e4_428f_a892_2a9a545c77f0
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:293
is: SBO:0000252
is: Q6I9V5
boundary condition: true
initial amount: NaN
type: Species
name: SLC25A6

metaM udp c
initial concentration: 1.0
is: C00015
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
has only substance units: false
is: HMDB00295
name: UDP
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2120
product: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true

metaR NDPK3n
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is described by: ECO:0000304
fast: false
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r0650
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110029#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#

metaR LACZe
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: b-galactosidase, extracellular
product: MODEL1310110029#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.2.1.108
reversible: false
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase

metaM lnlccoa r
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
is: HMDB01064
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial amount: NaN
name: linoleic coenzyme A
is: SBO:0000247
type: Species

metaR r1666
modifier: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM aps c
boundary condition: false
is: HMDB01003
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:58243
name: 5'-adenylyl sulfate(2-)

http://identifiers.org/biomodels.db/MODEL1310110029#_3615e154_db0a_4125_a4fc_54dff27fe5c8
is: O14986
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: PIP5K1B
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8395

http://identifiers.org/biomodels.db/MODEL1310110029#_e422b0a0_e6e6_48b1_b7ca_4e807516fc0c
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: RBAK
is encoded by: hsa:57786
is: Q9NYW8

metaM strdnc r
is: C16300
boundary condition: false
has only substance units: false
name: stearidonic acid C18:4, n-3
is: HMDB06547
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608

http://identifiers.org/biomodels.db/MODEL1310110029#_e1cbd818_a01a_47d9_95ce_c6a0152c77dc
initial amount: NaN
name: SLC20A1
boundary condition: true
is: Q8WUM9
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6574

metaR SUCCtp
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#
name: succinate transporter, peroxisome
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ

metaR ICDHy
is described by: ECO:0000269
name: isocitrate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase

metaM sph1p c
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial amount: NaN
constant: false
is: HMDB01383
is: SBO:0000247
is: CHEBI:57939
has only substance units: false
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
initial concentration: 1.0

metaM tchola c
initial amount: NaN
is: SBO:0000247
name: taurocholic acid
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:36257
is: HMDB00036
constant: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaM arachdcoa x
is: HMDB06523
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
initial concentration: 1.0
name: arachidonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110029#_fe8e3225_b03f_46a4_b511_d4029a0d7f26
is encoded by: hsa:3098
constant: false
is: A8K7J7
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: HK1
has only substance units: false
is: SBO:0000252

metaR r2419
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
reactant: MODEL1310110029#
fast: false
is: SBO:0000185

metaR RDH4
fast: false
name: retinol dehydrogenase (13-cis,NADH)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:9115228 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction

metaR PHEMEtm
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
reversible: true
is described by: ECO:0000000
product: MODEL1310110029#
name: Heme transport to cytosol

metaR SR5ARr
product: MODEL1310110029#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reversible: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.99.5
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
kinetic law: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d1e279f2_e86e_4ca1_bd4b_ee6314c6ddac
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: SLC13A4
constant: false
is: Q9UKG4
is encoded by: hsa:26266
has only substance units: false
initial concentration: NaN

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247
is: HMDB00027
boundary condition: false

metaM pi c
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
is: C00009
has only substance units: false
is: HMDB00973
initial amount: NaN
is: SBO:0000247
name: hydrogenphosphate
constant: false

metaM CE2705 n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:15374
constant: false
name: quinonoid dihydrobiopterin
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: SBO:0000247
is: HMDB02281

metaM ura e
is: CHEBI:17568
has only substance units: false
initial amount: NaN
name: uracil
is: HMDB00300
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR r1150
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000185
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
reversible: false
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM HC01231 m
is: SBO:0000247
has only substance units: false
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaR r2126
modifier: MODEL1310110029#
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110029#

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r2064
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0644
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reversible: true
kinetic law: MODEL1310110029#
fast: false

metaM pmtcoa x
boundary condition: false
is: CHEBI:57379
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: C00154
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01338
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0

metaM fadh2 x
constant: false
is: HMDB01197
has only substance units: false
name: FADH2(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: CHEBI:58307
initial concentration: 1.0

metaM pa hs m
is: SBO:0000247
has only substance units: false
name: phosphatidate(2-)
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
initial amount: NaN
is: CHEBI:57739
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_7ba8e986_0e38_41f0_bfcd_631e83c7a47d
is: SBO:0000252
initial concentration: NaN
name: ACOT12
is: Q5FWE9
is encoded by: hsa:134526
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR TKT1
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
modifier: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
name: transketolase
type: Reaction
fast: false
is described by: ECO:0000000

metaR r1052
is: SBO:0000185
name: Vesicular transport
reversible: false
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000

metaM glyc S e
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: 0
name: (S)-Glycerate
has only substance units: false
is: CHEBI:33871
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB06372

metaR DALAt2r
is described by: ECO:0000304
modifier: MODEL1310110029#
reversible: true
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
kinetic law: MODEL1310110029#
name: D-alanine transport via proton symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_cdc20bb8_7122_41b3_9aae_27071461e55b
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: _BE966236_1_m
type: Species
has only substance units: false
is encoded by: hsa:BE966236

metaR LCADi
is: SBO:0000176
modifier: MODEL1310110029#
reversible: false
fast: false
name: lactaldehyde dehydrogenase
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD

metaR r1659
reactant: MODEL1310110029#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_32646154_cf7a_4181_b224_b03ff5e73665
constant: false
is encoded by: hsa:5959
boundary condition: true
initial concentration: NaN
name: RDH5
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q92781
type: Species

metaR r2127
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#

metaM CE2434 m
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
is: C01936
initial concentration: 1.0
boundary condition: false

metaM tchola e
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
boundary condition: false
name: taurocholic acid
is: HMDB00036

metaR ACHtn
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
reversible: true
fast: false
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185

metaM lac L c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
is: CHEBI:16651
initial concentration: 1.0
initial amount: NaN
is: HMDB00190
type: Species
constant: false
name: (S)-lactate
has only substance units: false
boundary condition: false

metaR HSD17B42x
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: hydroxysteroid (17-beta) dehydrogenase 4
modifier: MODEL1310110029#
is described by: ECO:0000269

metaR r2089
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaR r1377
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaR r1881
fast: false
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: false
is: SBO:0000185
type: Reaction

metaM glu L m
is: CHEBI:29985
is: SBO:0000247
is: HMDB00148
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false

metaR RDH2
reversible: true
reactant: MODEL1310110029#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
fast: false
kinetic law: MODEL1310110029#
name: retinol dehydrogenase (9-cis,NADH)
is version of: http://identifiers.org/ec-code/1.1.1.315

metaM sph1p e
initial amount: NaN
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
is: HMDB01383
is: CHEBI:57939
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_d6949bb7_15b7_41cc_9705_4b2afe5fece6
initial concentration: NaN
boundary condition: true
name: AMY1A
initial amount: NaN
is: SBO:0000252
is: Q6NSB3
constant: false
has only substance units: false
type: Species
is encoded by: hsa:276

metaR TKT2
fast: false
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110029#
name: transketolase
is: SBO:0000176
reactant: MODEL1310110029#

metaR r0818
type: Reaction
reversible: false
reactant: MODEL1310110029#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
fast: false
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR r1658
product: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#

metaM 2hb c
constant: false
has only substance units: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 2-Hydroxybutyrate
is: CHEBI:1148
is: HMDB00008

metaR r0642
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_fb1247d1_93a6_4a1e_a7c0_ef7e6bf8c6a7
name: SDHB
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
type: Species
is: P21912
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r2088
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR CYSTGLUex
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110029#
name: L-cystine/L-glutamate exchanger
reversible: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185

metaM strdnc e
initial concentration: 1.0
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205608
boundary condition: false
is: HMDB06547
is: SBO:0000247
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
constant: false
is: C16300

http://identifiers.org/biomodels.db/MODEL1310110029#_833bd5da_423a_48c2_ada3_803454e6a989
constant: false
name: PLCB2
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5330
initial concentration: NaN
is: Q59F77
boundary condition: true
is: SBO:0000252

metaR r2124
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110029#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FADtx
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
type: Reaction
name: FAD transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false
kinetic law: MODEL1310110029#

metaR RDH3
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: retinol dehydrogenase (11-cis,NADH)
modifier: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
reversible: true
reactant: MODEL1310110029#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_90236cae_d22b_417e_87c7_06db1f723a05
is: Q8N1Q1
is: SBO:0000252
initial concentration: NaN
name: CA13
type: Species
is encoded by: hsa:377677
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

metaM 2hb e
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00008
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
type: Species
is: CHEBI:1148
boundary condition: false

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110029#

metaM gln L m
constant: false
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
is: HMDB00641
initial amount: NaN
type: Species
is: CHEBI:18050
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR RE0915E
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0915
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a36e73be_52ba_4362_8e5c_c78eea300deb
name: UGP2
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7360
is: Q16851
constant: false

metaR FACOAL80i
modifier: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110029#
type: Reaction
reversible: false
name: fatty-acid--CoA ligase (octanoate)
is described by: ECO:0000269
fast: false

metaR GCALDD
reactant: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110029#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM Rtotal2 e
initial concentration: 1.0
initial amount: NaN
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
constant: false
type: Species
is: CHEBI:3554
is: C00255
name: R total 2 position
boundary condition: false
is: SBO:0000247

metaM spmd e
is: SBO:0000247
name: Spermidine
is: C00315
initial concentration: 1.0
is: HMDB01257
is: CHEBI:57834
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR r2125
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false

metaR r1657
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185

metaM CE5236 c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28002
type: Species

metaR r2087
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_1f5ff2f1_937b_4716_880f_a40e5279d976
is: Q9HC58
initial amount: NaN
name: SLC24A3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57419
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM leuktrF4 e
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:27491
name: leukotriene F4
initial concentration: 1.0

metaR EX 13 cis retnglc LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 13-cis-retinoyl glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6cea1c22_661a_4185_aa3e_d85d578022d2
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: DHCR24
is: SBO:0000252
is: Q15392
is encoded by: hsa:1718

metaR H2Oter
kinetic law: MODEL1310110029#
reversible: true
name: H2O endoplasmic reticulum transport
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_757e37d9_8714_4e1a_be31_eae8632566b4
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: ADH5
is encoded by: hsa:128
initial amount: NaN
has only substance units: false
is: Q6IRT1

metaM strdnc l
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB06547
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
is: SBO:0000247
is: C16300
constant: false

metaM but c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial concentration: 1.0
is: HMDB00039
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_6c558a0d_01be_4a13_b081_699317fdfe70
is: O15121
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: DEGS1
has only substance units: false
is encoded by: hsa:8560
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_904ef43c_58d6_460d_88e2_ffde3a119927
initial amount: NaN
name: ATP2B3
is: SBO:0000252
type: Species
is: Q16720
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:492
constant: false

metaM pyr m
is: C00022
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: HMDB00243
type: Species
is: CHEBI:15361
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
boundary condition: false

metaR r2086
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR 7DHCHSTEROLtr
is: SBO:0000185
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol precursor intracellular transport
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

metaM pi g
has only substance units: false
type: Species
initial amount: NaN
name: hydrogenphosphate
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_cacd983b_f732_4c5d_a7a7_08e048a4fa13
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: ALDH3B1
is: P43353
is encoded by: hsa:221
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_741bcbd1_4640_4e53_b465_3516d8c83d5e
is encoded by: hsa:29922
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: NME7

metaM q10 m
type: Species
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: CHEBI:46245
is: SBO:0000247
name: ubiquinone-10
is: HMDB01072
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR GLNS
reversible: false
is described by: ECO:0000254
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
name: glutamine synthetase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110029#

metaR TRPt
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000269
product: MODEL1310110029#
name: L-tryptophan transport
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110029#

metaR NTP3e
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_638ec70f_c017_4df2_a4f6_c4d531be6c47
constant: false
initial amount: NaN
is encoded by: hsa:2731
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GLDC
is: SBO:0000252
type: Species
is: P23378

metaR ACCOAtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110029#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: acetyl-CoA transport, nuclear
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR RDH1
name: retinol dehydrogenase (all-trans)
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_273ee08a_a801_472c_8520_10ba961173c5
boundary condition: true
is encoded by: hsa:80201
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: B3KT70
type: Species
name: HKDC1

metaM tststerone e
initial amount: NaN
is: CHEBI:17347
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: HMDB00234
name: testosterone
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_8a56b653_32d4_4ea5_b0ad_2454c8aa6372
is encoded by: hsa:6582
boundary condition: true
name: SLC22A2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR H2O2t
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
name: hydrogen peroxide transport via diffusion
type: Reaction
is described by: ECO:0000000

metaM ppi e
name: Diphosphate
type: Species
initial amount: NaN
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
constant: false
is: CHEBI:33019
has only substance units: false
is: C00013
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_09bcc4c2_34e8_4174_860b_f11e2f492b75
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ATIC
is encoded by: hsa:471
is: P31939
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6ac1e715_9d53_4f69_a83e_db72f2e0f01a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50700
initial amount: NaN
is: Q9NYR8
boundary condition: true
constant: false
name: RDH8
has only substance units: false
type: Species

metaR CYANt
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
name: Cyanide transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false

metaR r2085
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110029#
reversible: true

metaM ctp c
is: C00063
is: CHEBI:37563
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
name: CTP
is: HMDB00082
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a40388ba_728c_4eb5_9101_5938ffbbf1e5
constant: false
is: Q9UGH3
name: SLC23A2
boundary condition: true
is encoded by: hsa:9962
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR CYTK14n
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear

metaR r1998
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR r0647
fast: false
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: Spontaneous reaction

metaR RPE
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.1
reactant: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
name: ribulose 5-phosphate 3-epimerase
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
type: Reaction
product: MODEL1310110029#

metaM pi e
is: CHEBI:43474
is: C00009
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00973
is: SBO:0000247
constant: false
name: hydrogenphosphate
type: Species

metaM 3m4hpga c
is: HMDB04061
is: http://identifiers.org/pubchem.compound/7909
is: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
constant: false
boundary condition: false
type: Species

metaM but e
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00039
is: CHEBI:17968
name: butyrate
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_39644f29_9d04_463c_8681_ccf310872a7f
has only substance units: false
name: TK1
type: Species
is: P04183
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7083
boundary condition: true

metaM ura c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: Uracil
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17568
is: C00106
is: HMDB00300

metaR r2083
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
is: SBO:0000185

metaR r2084
reactant: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

metaM pmtcoa r
is: CHEBI:3454
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false
is: C00154
is: HMDB01338

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,4,5-trisphosphate 5-phosphatase
fast: false
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000269

metaR r1378
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM HC00460 c
name: 2,5-dihydroxybenzoate
constant: false
initial concentration: 1.0
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_971a1e67_5692_4e1c_8db9_97dbe1671bc7
is encoded by: hsa:100128062
constant: false
name: _100128062_1_m
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_3e3fa86a_16ca_48ed_a110_41fa891a7aac
is encoded by: hsa:4694
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q6IBB5
name: NDUFA1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c34a8860_a24f_4612_b415_85098af62f47
is encoded by: hsa:55312
type: Species
initial concentration: NaN
name: RFK
is: B2RDZ2
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

metaR r0130
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

http://identifiers.org/biomodels.db/MODEL1310110029#_9ccaecb9_3cdf_42c8_9689_3a5da5921b35
is: E7EPT3
initial amount: NaN
is encoded by: hsa:501
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: ALDH7A1
type: Species
initial concentration: NaN

metaM leuktrF4 c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:27491
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB06465

metaR H2O2syn
is described by: ECO:0000304
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.6.3.1
product: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Hydrogen peroxide synthesis (NADPH dependent)
reversible: false
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
type: Reaction
is: SBO:0000176
fast: false

metaR r2128
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r0899
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reversible: true

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
type: Species
name: (R)-lactate
is: CHEBI:16004
is: HMDB01311
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_6766d0b2_cbc3_49db_8525_a7b8cd095c88
boundary condition: true
is encoded by: hsa:3028
is: SBO:0000252
name: HSD17B10
initial concentration: NaN
constant: false
is: Q99714
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_2c5dac1e_106d_4b9e_ad67_267e63a7123c
name: CTH
is encoded by: hsa:1491
has only substance units: false
is: P32929
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_b6819360_df9f_498c_a5ba_0cc57bc5d74a
has only substance units: false
type: Species
boundary condition: true
is: Q15735
name: INPP5J
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27124
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_d78dd20c_a2f5_4fe1_b690_37ee5b747a59
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: _2544_1_c
is encoded by: hsa:2544
is: SBO:0000252
initial concentration: NaN
type: Species

metaM glyc S c
notes: FORMULA: C3H5O4 CHARGE: 0
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:33871
is: HMDB06372
initial amount: NaN
name: (S)-Glycerate

metaM lac L e
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00190
is: CHEBI:16651
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
name: (S)-lactate

metaM 3hbcoa m
initial concentration: 1.0
is: HMDB01166
type: Species
is: CHEBI:57316
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

http://identifiers.org/biomodels.db/MODEL1310110029#_fcd4216f_4ce4_495f_91b2_0132e2263019
is encoded by: hsa:2879
is: P36969
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GPX4
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2082
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM glyc e
is: HMDB00131
is: C00116
name: Glycerol
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247

metaR r0068
is version of: http://identifiers.org/ec-code/3.1.2.1
kinetic law: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
is: SBO:0000176
modifier: MODEL1310110029#
fast: false

metaM ppi c
name: Diphosphate
is: SBO:0000247
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
is: HMDB00250
is: CHEBI:0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110029#_3c965314_5aa8_481c_9ef0_2c4a8a5c4c6a
is: SBO:0000252
is: Q5JT09
is encoded by: hsa:83549
initial concentration: NaN
constant: false
type: Species
name: UCK1
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ctp e
is: SBO:0000247
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
constant: false
name: CTP(4-)
boundary condition: false
is: HMDB00082
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r2129
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GLYBt4 2 r
is: SBO:0000185
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: Betaine transport (sodium symport) (2:1)
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_bc22acf8_9f05_4457_b5d0_1f1a9c4b9b3d
is: P31937
initial concentration: NaN
type: Species
is encoded by: hsa:11112
name: HIBADH
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR r1596
is: SBO:0000185
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ddacc1e7_444a_419a_9e69_0457489c1b64
initial concentration: NaN
is encoded by: hsa:9962
has only substance units: false
initial amount: NaN
name: SLC23A2
boundary condition: true
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_fde10e14_2f23_4214_9777_3339d9890398
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA081045
has only substance units: false
constant: false
name: _AA081045_1_e

metaM fru e
is: HMDB00660
is: SBO:0000247
initial concentration: 1.0
is: C00095
name: D-Fructose
type: Species
boundary condition: false
is: CHEBI:15824
initial amount: NaN
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_92f468ed_14d0_4861_b403_18435c2671e7
has only substance units: false
initial amount: NaN
boundary condition: true
is: P53597
type: Species
initial concentration: NaN
constant: false
name: SUCLG1
is encoded by: hsa:8802
is: SBO:0000252

metaM 34dhoxmand m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
constant: false
is: SBO:0000247

metaR KHte
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000134
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
is: SBO:0000185

metaR r2343
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_b354aeb5_6815_4801_ad37_371a77e5c873
initial concentration: NaN
is encoded by: hsa:123041
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: SLC24A4
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_ab9f6bc5_40b1_485d_b12f_0d38ea4e2e0d
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:130
initial amount: NaN
is: P28332
name: ADH6

metaM man1p c
is: HMDB06330
boundary condition: false
constant: false
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:35374
initial amount: NaN
initial concentration: 1.0

metaR ALADGLNexR
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000304
type: Reaction
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
fast: false
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_22d70085_8e0c_4bd1_a5c5_050f626fb288
has only substance units: false
initial concentration: NaN
is: P33316
type: Species
is: SBO:0000252
initial amount: NaN
name: DUT
constant: false
boundary condition: true
is encoded by: hsa:1854

http://identifiers.org/biomodels.db/MODEL1310110029#_afbfca91_a322_4555_a75a_e28facca66fb
constant: false
initial concentration: NaN
is: Q8N4Q0
is: SBO:0000252
type: Species
name: ZADH2
is encoded by: hsa:284273
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_be69ffdc_157e_44c2_a996_267a9884adab
is: P15309
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:55
name: ACPP
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_c4d70a26_0555_48b0_beb6_718de00ffe4a
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9NWW6
has only substance units: false
type: Species
boundary condition: true
name: NMRK1
is encoded by: hsa:54981

http://identifiers.org/biomodels.db/MODEL1310110029#_fa2b1b4f_9088_407c_8191_c997bad7a4dc
is encoded by: hsa:2348
boundary condition: true
name: FOLR1
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaM gln L c
has only substance units: false
initial concentration: 1.0
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
initial amount: NaN
is: CHEBI:18050
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00641

http://identifiers.org/biomodels.db/MODEL1310110029#_3e2a8170_dee4_4fb2_a95e_8fea8344782f
name: NME1:NME2
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:4830
type: Species
has only substance units: false
initial amount: NaN

metaM udp n
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58223
constant: false
name: UDP(3-)
boundary condition: false
type: Species

metaR r1597
reactant: MODEL1310110029#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaM cyan m
is: HMDB02084
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
type: Species

metaM HC02213 c
boundary condition: false
is: CHEBI:28031
name: prostaglandin-e3
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_63270469_5845_45b5_8440_229e8f0cf1c3
is encoded by: hsa:4535
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: Q85KV6
initial concentration: NaN
initial amount: NaN
constant: false
name: ND1

metaM cdpdag hs m
boundary condition: false
constant: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: CDP-diacylglycerol(2-)
initial amount: NaN
is: CHEBI:58332

metaM CE5236 n
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28002
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaR r1429
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
name: Free diffusion
reversible: true

metaR DNDPt25m
modifier: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
name: dTDP transport via dCDP antiport
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaR r1598
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_9e09887c_0223_4294_a0da_c5930f090cd6
is encoded by: hsa:219
constant: false
initial amount: NaN
boundary condition: true
name: ALDH1B1
has only substance units: false
is: P30837
is: SBO:0000252
type: Species
initial concentration: NaN

metaM pppg9 m
is: SBO:0000247
initial amount: NaN
is: CHEBI:57307
name: Protoporphyrinogen IX
type: Species
initial concentration: 1.0
notes: FORMULA: C34H38N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00656 EHMN_ABBREVIATION: C01079
has only substance units: false
is: HMDB01097
boundary condition: false
is: C01079
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_43fd8449_4b9e_4f01_acc6_f9e1843efc39
name: SLC17A2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10246
initial amount: NaN
boundary condition: true
type: Species
is: O00624
is: SBO:0000252
constant: false

metaR NMNATr
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: nicotinamide-nucleotide adenylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1

metaR r1428
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110029#
fast: false
name: Free diffusion
is: SBO:0000185

metaR r0287
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
modifier: MODEL1310110029#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reversible: false
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaR RIBt
kinetic law: MODEL1310110029#
reversible: true
name: ribose transport via diffusion
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR GCHOLAte
reversible: true
reactant: MODEL1310110029#
name: bile acid intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_7f96dd75_7730_4c01_ac92_07a167e80d90
type: Species
name: _AI971036_1_m
constant: false
is encoded by: hsa:AI971036
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM dutp c
is: CHEBI:17625
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: C00460
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB01191
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2aed603f_986a_44e5_8cd7_0cdb0158485d
is: P00441
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:6647
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: SOD1

metaM gluside hs c
has only substance units: false
is: CHEBI:18368
initial amount: NaN
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR CYTDtm
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
name: cytidine facilated transport in mitochondria
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_e5b37536_4ed4_4a23_a4c5_5d5b12816899
is: SBO:0000252
name: _M68895_1_c
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:M68895
boundary condition: true

metaR CMPSASn
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
product: MODEL1310110029#
name: CMP sialic acid synthase, nuclear
modifier: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_4c532b1e_1bab_4cde_811e_b486ba95d275
has part: A8K7W0
is: SBO:0000297
has part: O95497
has only substance units: false
type: Species
is encoded by: hsa:55350
initial amount: NaN
name: VNN3:VNN2:VNN1
is encoded by: hsa:8876
initial concentration: NaN
is encoded by: hsa:8875
boundary condition: true
constant: false

metaM gln L e
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18050
name: L-glutamine
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: HMDB00641
type: Species

metaM nad x
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: CHEBI:57540
boundary condition: false
initial amount: NaN
constant: false
is: C00003
initial concentration: 1.0
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: SBO:0000247

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR r1427
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110029#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00259
initial concentration: 1.0
is: CHEBI:350546
type: Species
constant: false
name: serotonin(1+)

http://identifiers.org/biomodels.db/MODEL1310110029#_ccf8e088_ec00_4d8a_a87d_7155460adad9
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:AA502753
has only substance units: false
constant: false
is: SBO:0000252
name: _AA502753_1_m
initial concentration: NaN

metaM 1glyc hs e
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
initial amount: NaN
is: SBO:0000247
name: 1 acyl phosphoglycerol
type: Species
is: CHEBI:28870
constant: false
initial concentration: 1.0
is: HMDB03141
has only substance units: false
boundary condition: false

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_7bba3370_b6a9_47fc_b960_016e6afc483e
constant: false
has only substance units: false
boundary condition: true
name: ALDH7A1
is: SBO:0000252
is: E7EPT3
is encoded by: hsa:501
initial concentration: NaN
type: Species
initial amount: NaN

metaM ser D c
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
is: HMDB03406
is: CHEBI:16523
name: D-serine
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_242ea111_792a_4d4f_b660_0a40466e27a2
has only substance units: false
name: MPI
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P34949
boundary condition: true
initial amount: NaN
is encoded by: hsa:4351

metaM tststerone c
is: HMDB00234
has only substance units: false
is: SBO:0000247
is: CHEBI:17347
initial concentration: 1.0
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false
name: testosterone
initial amount: NaN
type: Species

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaM strdnc c
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
constant: false
is: C16300
name: stearidonic acid C18:4, n-3
type: Species
is: HMDB06547
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#

metaR r0422
product: MODEL1310110029#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110029#
is: SBO:0000176

metaM gsn e
constant: false
type: Species
is: C00387
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16750
is: HMDB00133
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
name: Guanosine
initial amount: NaN

metaR r2347
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM 2mbcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB01041
constant: false
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57336

http://identifiers.org/biomodels.db/MODEL1310110029#_57470422_dcf1_4a7b_ba73_cb7f2aa70b2d
boundary condition: true
is encoded by: hsa:83715
name: ESPN
constant: false
initial concentration: NaN
initial amount: NaN
is: B1AK53
has only substance units: false
type: Species
is: SBO:0000252

metaR BDHm
kinetic law: MODEL1310110029#
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
product: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

metaR SBT Dtde
is: SBO:0000185
type: Reaction
name: D-sorbitol transport, extracellular
fast: false
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134

metaM udp r
name: UDP
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00295
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: C00015
has only substance units: false
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110029#_da335700_5130_466f_8971_c2f334cdb487
is encoded by: hsa:4129
constant: false
is: P27338
is: SBO:0000252
has only substance units: false
name: MAOB
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM xu5p D c
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: D-xylulose 5-phosphate(2-)
is: HMDB00868
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110029#_ae023d91_6022_443e_94ec_4768a92e06af
name: ENTPD3
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: O75355
is encoded by: hsa:956

metaR GCC2am
fast: false
is described by: ECO:0000269
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true

metaR FAOXC101C8m
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM vitd3 e
is: CHEBI:28940
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
is: HMDB00876
has only substance units: false
type: Species
name: calciol

metaR r1593
is: SBO:0000185
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110029#

metaM srtn c
boundary condition: false
constant: false
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:350546
is: HMDB00259
name: serotonin(1+)

http://identifiers.org/biomodels.db/MODEL1310110029#_c77576ca_eae9_48a7_91e0_c95bac269b03
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: NDUFA11
is encoded by: hsa:126328
has only substance units: false
initial concentration: NaN
is: C9JT23

metaM tdchola c
name: taurochenodeoxycholate
has only substance units: false
type: Species
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:9407
is: HMDB00951
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_0bf98f10_c9a8_4572_b24a_8910b48f6d7c
is encoded by: hsa:2878
type: Species
initial amount: NaN
has only substance units: false
is: P22352
boundary condition: true
name: GPX3
constant: false
is: SBO:0000252
initial concentration: NaN

metaM octa c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
initial amount: NaN
constant: false
is: CHEBI:25646
is: HMDB00482
is: C06423
has only substance units: false
type: Species
is: SBO:0000247

metaM pi n
is: HMDB00973
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: hydrogenphosphate
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110029#_c8a119a5_29cb_4780_b9d1_8344b71b2810
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: _D29675_1_c
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:D29675

metaR r2346
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110029#
fast: false

metaR G5SADrm
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_43a9c748_e5f9_49cf_a0ab_99123a0e1b32
has only substance units: false
is: P49915
name: GMPS
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:8833
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2e0a9a29_f88a_40b3_9b64_589452ebb72a
name: GALE
initial concentration: NaN
is encoded by: hsa:2582
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q14376
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_98939620_f986_49a1_a3c4_25d31b767564
is encoded by: hsa:3939
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3945
name: LDHA:LDHB
constant: false
type: Species
is: SBO:0000297
has part: P00338
has part: P07195

http://identifiers.org/biomodels.db/MODEL1310110029#_8e2191df_21c5_4618_ae54_b95ed5f18d1a
is: Q8N5Z0
is encoded by: hsa:51166
constant: false
is: SBO:0000252
initial concentration: NaN
name: AADAT
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR CGLYt3 2
product: MODEL1310110029#
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
is: SBO:0000185
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_c691f66d_6662_4e52_a44e_21b51bf810b6
boundary condition: true
is: Q99424
initial concentration: NaN
has only substance units: false
name: ACOX2
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8309

metaR TDCHOLAte
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: bile acid intracellular transport
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM pyr c
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
initial amount: NaN
name: pyruvate
is: C00022
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: HMDB00243
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM q10 e
has only substance units: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01072
boundary condition: false
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110029#_27318ad7_e5de_4ee7_b1dc_7b5a73972be7
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110029#_eac1df6c_ae20_4899_b6e4_ad22f5e9630b
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110029#_0cdf613f_b81d_4cf3_bd78_0fbfa3895edb
initial concentration: NaN
is encoded by: hsa:2876
constant: false
initial amount: NaN
name: GPX1
type: Species
has only substance units: false
is: SBO:0000252
is: P07203
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_ecc5b68d_d4f1_4378_bb48_6dd2b38c2a8a
type: Species
name: SLC25A1
is: D9HTE9
initial amount: NaN
is encoded by: hsa:6576
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM fru c
is: SBO:0000247
is: C00095
name: D-Fructose
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00660
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_44e3e757_8849_4d8a_91a8_6991872fce1d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: B4DDW0
is encoded by: hsa:51109
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: RDH11

http://identifiers.org/biomodels.db/MODEL1310110029#_df76c4d1_232b_4a81_8b10_f5f7e6be2e42
name: _AW277253_1_c
initial concentration: NaN
is encoded by: hsa:AW277253
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1594
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR TAURCHAe
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
is described by: ECO:0000134
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
reversible: false
name: exit of taurine from the enterocytes

metaM pi m
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: CHEBI:43474
name: hydrogenphosphate
is: HMDB00973
is: SBO:0000247
is: C00009

http://identifiers.org/biomodels.db/MODEL1310110029#_ec95740a_3001_485f_b33a_7296ef1bb8e7
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q9NST1
is encoded by: hsa:80339
is: SBO:0000252
has only substance units: false
type: Species
name: PNPLA3

metaM cytd c
is: HMDB00089
is: SBO:0000247
is: CHEBI:17562
has only substance units: false
boundary condition: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
type: Species
name: Cytidine
initial concentration: 1.0
is: C00475
initial amount: NaN
constant: false

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_7f56a383_0348_403c_81ab_39a3d2121c4a
name: DCK
is: P27707
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1633
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_f1cb95ad_ffc5_48e9_ae38_26d3aafb42dd
is: SBO:0000252
is: Q9UJM8
is encoded by: hsa:54363
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: HAO1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_4f4740ce_7eeb_48a4_b394_ddeefa83e6b5
type: Species
boundary condition: true
constant: false
name: GLUD1
is: E9KL48
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2746
is: SBO:0000252

metaR r1595
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185

metaM tdchola e
is: HMDB00951
has only substance units: false
is: SBO:0000247
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
initial amount: NaN
is: CHEBI:9407
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_2ad2a442_3485_4986_8290_75f6a42bd53e
type: Species
name: ALDH2
is: P05091
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:217
initial concentration: NaN
is: SBO:0000252

metaM glyc m
is: CHEBI:17754
initial amount: NaN
is: SBO:0000247
is: C00116
has only substance units: false
constant: false
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_25f6adab_f32a_4749_892f_868059ec2f2b
initial amount: NaN
is: Q8NFW8
is encoded by: hsa:55907
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: CMAS
is: SBO:0000252
has only substance units: false

metaR r1500
is described by: ECO:0000000
kinetic law: MODEL1310110029#
fast: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
reactant: MODEL1310110029#

metaM glyc R m
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00139
name: D-glycerate
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
is: SBO:0000247
constant: false

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM octa e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
is: CHEBI:25646
is: HMDB00482
is: C06423
type: Species
is: SBO:0000247
has only substance units: false

metaM pi l
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474

metaM hgentis c
is: SBO:0000247
is: CHEBI:16169
is: HMDB00130
initial concentration: 1.0
type: Species
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: homogentisate

metaR r0926
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
product: MODEL1310110029#
fast: false
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_cfbc19d3_37d8_4132_bcf7_a2c94684d610
has only substance units: false
name: HMBS
is encoded by: hsa:3145
initial concentration: NaN
is: P08397
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaR LEUKTRA4t
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
name: leukotriene A4 transport
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:

metaM HC02213 e
is: CHEBI:28031
constant: false
name: prostaglandin-e3
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r1050
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
type: Reaction
name: Vesicular transport
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM pyr e
is: CHEBI:15361
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: HMDB00243
name: pyruvate
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM so3 c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00240
initial amount: NaN
is: C00094
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
name: Sulfite

metaM asn L e
is: HMDB00168
name: L-asparagine
constant: false
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_70d10d0b_ea4b_4618_9e3c_dbfc66689724
constant: false
boundary condition: true
is encoded by: hsa:3032
is: SBO:0000252
has only substance units: false
name: HADHB
is: P55084
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
name: Utilized transport
fast: false
is described by: ECO:0000000

metaM q10 c
has only substance units: false
is: CHEBI:46245
is: SBO:0000247
constant: false
boundary condition: false
name: ubiquinone-10
is: HMDB01072
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
initial concentration: 1.0

metaM ribflv e
name: Riboflavin
is: C00255
initial amount: NaN
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:3554
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00244

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
is: SBO:0000176
product: MODEL1310110029#

metaM g1p c
boundary condition: false
is: C00103
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB01586
is: CHEBI:58601

metaR HSD3B12r
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction

metaR r0494
is: SBO:0000176
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_4771b5d4_8717_4242_a890_368ee9208362
is encoded by: hsa:7378
constant: false
type: Species
name: UPP1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r0552
fast: false
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_db107554_694a_44d3_a6f0_ec6fbd24bba0
boundary condition: true
type: Species
name: GMPPB
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29925
is: SBO:0000252
initial amount: NaN
constant: false

metaM mal L e
is: HMDB00156
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15589

metaM glc D r
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_bc7e2c4d_9405_4468_a65a_a4cf6520e535
has only substance units: false
initial concentration: NaN
is encoded by: hsa:53905
constant: false
boundary condition: true
initial amount: NaN
name: DUOX1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_839a8297_7138_405c_836d_c1b4d454204f
is: P50440
initial concentration: NaN
name: GATM
has only substance units: false
is encoded by: hsa:2628
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaR DIGALSIDEtg
is described by: ECO:0000000
product: MODEL1310110029#
type: Reaction
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
name: digalside hs intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR r2507
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

metaR CYTK10
is described by: ECO:0000269
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dGTP)
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110029#

metaM 3pg m
constant: false
type: Species
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
initial concentration: 1.0
is: CHEBI:58272
is: HMDB00807

metaM gsn c
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00133
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
name: Guanosine
is: SBO:0000247
is: C00387
is: CHEBI:16750

metaR r0553
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110029#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_454eefe2_25bc_417a_9385_b832133a1693
is encoded by: hsa:6531
is: SBO:0000252
constant: false
is: Q01959
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC6A3
type: Species

metaR r0911
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reactant: MODEL1310110029#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_db475540_3e84_44a8_8a87_fac89e179f50
is encoded by: hsa:2645
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q53Y25
name: GCK
type: Species
boundary condition: true
initial concentration: NaN

metaR r0400
product: MODEL1310110029#
reactant: MODEL1310110029#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
modifier: MODEL1310110029#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:

metaR r1711
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_50646052_e03f_4e1b_9aa0_4401bc4d5bb8
type: Species
is: P46721
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6579
is: SBO:0000252
constant: false
name: SLCO1A2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_7b491cc4_5393_45f2_a92e_a774b4d50872
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4729
boundary condition: true
initial amount: NaN
constant: false
name: NDUFV2
has only substance units: false
is: P19404

metaM o2 r
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
name: O2
type: Species
is: C00007
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:15379
initial concentration: 1.0
is: HMDB01377

metaM 6dhf e
name: hexaglutamyl folate (DHF)
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06563
initial concentration: 1.0

metaM HC02207 c
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:27555
initial concentration: 1.0
name: prostaglandin-c2

metaM so3 m
is: CHEBI:17137
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
has only substance units: false
is: HMDB00240
name: hydrogensulfite
is: SBO:0000247

metaR CYTK11
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP)

http://identifiers.org/biomodels.db/MODEL1310110029#_32949ef9_ccb8_4b11_8fa6_216ee40c6890
is encoded by: hsa:1607
has only substance units: false
is: Q9Y6T7
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: DGKB
type: Species

metaR PCHOLPg hs
reactant: MODEL1310110029#
product: MODEL1310110029#
name: choline phosphatase
reversible: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
fast: false
modifier: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_285eb904_1e3b_4c55_b752_fc3d3c074b3f
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CTPS1
has only substance units: false
is: P17812
constant: false
type: Species
is encoded by: hsa:1503

metaM lnlccrn m
is: SBO:0000247
boundary condition: false
is: HMDB06469
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_ca1c1273_89f2_4fad_8063_7e02403eaa27
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: BCAT2
has only substance units: false
is encoded by: hsa:587
type: Species
is: O15382

metaM btn e
type: Species
name: Biotin
initial concentration: 1.0
is: SBO:0000247
is: HMDB00030
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: CHEBI:3420
is: C00120
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_adf2f979_4b19_4903_9a67_555125e89351
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACOT6
is: Q3I5F7
constant: false
is encoded by: hsa:641372
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b837b3cf_9bf3_4ebc_859f_ec2bbe67d356
constant: false
is: P52790
is encoded by: hsa:3101
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: HK3
has only substance units: false

metaR r1446
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
type: Reaction
name: EC:1.3.3.6
kinetic law: MODEL1310110029#

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a494143b_d0ea_403e_bf84_82e9c90bd526
is: Q6IBA0
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: NDUFS5
has only substance units: false
is encoded by: hsa:4725
initial concentration: NaN
type: Species

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM paps c
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB01134
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaM mi1345p c
boundary condition: false
has only substance units: false
is: CHEBI:57895
is: HMDB01059
initial amount: NaN
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110029#
product: MODEL1310110029#
name: cytidylate kinase (dCMP,dCTP)
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR GLYBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
reversible: true
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM HC02207 e
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2

http://identifiers.org/biomodels.db/MODEL1310110029#_058792ba_3ca1_44d6_a9cc_4643408a776f
name: TKTL2
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:84076
is: Q9H0I9
constant: false

metaR SARDHm
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.1
fast: false
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
product: MODEL1310110029#
reversible: false
name: Sarcosine dehydrogenase (m)
modifier: MODEL1310110029#

metaM pchol hs m
is: SBO:0000247
name: Phosphatidylcholine
initial concentration: 1.0
is: CHEBI:16110
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaM retinal 11 cis c
type: Species
constant: false
is: CHEBI:16066
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
is: HMDB02152
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c5e43b7e_32b2_4268_9128_f536d967c7f2
type: Species
name: IK
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3550
is: Q13123
boundary condition: true
is: SBO:0000252

metaM pail45p hs c
constant: false
is: CHEBI:28910
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
initial amount: NaN
type: Species

metaM 1pipdn2c x
type: Species
has only substance units: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false
is: HMDB01084
initial concentration: 1.0
is: CHEBI:16187
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 1-piperideine-2-carboxylate

metaR r0345
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reversible: true
type: Reaction
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110029#

metaM arachd l
boundary condition: false
is: CHEBI:32395
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
initial amount: NaN
is: SBO:0000247
constant: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_d64344de_6c88_42a0_a829_ef340f7d8934
constant: false
initial amount: NaN
boundary condition: true
name: HADH
initial concentration: NaN
is encoded by: hsa:3033
is: Q16836
has only substance units: false
is: SBO:0000252
type: Species

metaR MGSA
product: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
fast: false
reversible: false
kinetic law: MODEL1310110029#
is: SBO:0000176
name: methylglyoxal synthase

metaM xol7ah2al c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
boundary condition: false
is: HMDB06894
has only substance units: false
is: CHEBI:27428
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al

http://identifiers.org/biomodels.db/MODEL1310110029#_dd21aed1_8f77_4862_a3c7_954e144fdedd
type: Species
name: ACADL
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:33
is: P28330
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r2352
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110029#_e00aa10d_4690_4550_817a_34668e253618
type: Species
initial concentration: NaN
name: AUH
is: SBO:0000252
constant: false
is: Q13825
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:549

http://identifiers.org/biomodels.db/MODEL1310110029#_a62eb47b_f567_423b_8a1d_5fa3daad456c
constant: false
is: Q5QPH3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55902
name: ACSS2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR PHCDm
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
reversible: false

metaR r0497
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

http://identifiers.org/biomodels.db/MODEL1310110029#_ced774a6_3354_4254_ad9c_4bf544eaba3e
constant: false
is encoded by: hsa:5740
name: PTGIS
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q16647
has only substance units: false
initial concentration: NaN

metaR O2t
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: o2 transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaM nadph x
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
has only substance units: false
constant: false
is: CHEBI:57783
is: HMDB00221
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00005

metaM btn c
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
type: Species
is: CHEBI:3420
name: Biotin
is: HMDB00030
is: C00120
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR DM atp c
reversible: false
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
name: DM atp(c)
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR SARCStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110029#
reversible: false
type: Reaction
fast: false
name: Sarcosine transport (mitochondrial)
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_c998ff38_6b96_487e_86c5_5f46c30165da
has only substance units: false
boundary condition: true
name: PLCD3
is encoded by: hsa:113026
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q8N3E9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_efac88db_b7cb_49b3_a9df_48b311f0a564
is: Q38G75
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: GALE
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:2582

metaR RE1521M
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1521
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

metaR MI14PP
reactant: MODEL1310110029#
name: inositol-1,4-bisphosphate 1-phosphatase
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.57
reversible: false

metaR r2353
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaM ribflv c
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
is: C00255
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:3554
name: Riboflavin
is: HMDB00244

metaR NADtru
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
name: NAD transporter, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_e3b0d793_dc63_4a2e_a071_d178be044f4e
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: UPB1
initial amount: NaN
is encoded by: hsa:51733
is: B3KNC1
type: Species

metaM 4abutn c
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: C00555
is: HMDB01080
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: 4-Aminobutanal
is: CHEBI:58264

metaM asn L c
initial amount: NaN
name: L-asparagine
type: Species
is: HMDB00168
constant: false
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
has only substance units: false
is: CHEBI:17196
is: SBO:0000247

metaR CHSTEROLtrc
reactant: MODEL1310110029#
is described by: ECO:0000134
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
name: transport of cholesterol into the cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
kinetic law: MODEL1310110029#

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM sarcs m
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
is: C00213
initial amount: NaN
constant: false
is: SBO:0000247
name: Sarcosine
is: HMDB00271
is: CHEBI:15611
has only substance units: false
type: Species
initial concentration: 1.0

metaR TREHe
product: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
reversible: false
name: alpha,alpha-trehalase
is: SBO:0000176

metaM fadh2 m
type: Species
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: HMDB01197
has only substance units: false
initial amount: NaN
name: Flavin adenine dinucleotide reduced
is: SBO:0000247
initial concentration: 1.0
is: C01352
boundary condition: false

metaR 3SALATAi
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110029#
name: 3-sulfino-alanine transaminase (irreversible)
product: MODEL1310110029#
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

http://identifiers.org/biomodels.db/MODEL1310110029#_23fdd010_cf81_4f48_8f40_21d691864d8e
has only substance units: false
constant: false
is: O14735
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: CDIPT
is encoded by: hsa:10423
boundary condition: true

metaR r2508
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM CE5854 e
is: CHEBI:27485
name: gama-CEHC-glucuronide
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB02710
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_4d70ff4c_1390_4f99_8e2b_082e9ecefac3
name: MTHFD2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P13995
is: SBO:0000252
is encoded by: hsa:10797
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7102b8bb_ea4f_43ed_ad86_c447e2e96be0
is encoded by: hsa:2180
type: Species
has only substance units: false
constant: false
is: P33121
name: ACSL1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR Coqe
fast: false
reversible: true
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of q10
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a0cc4726_733f_440d_a029_6d4cb003c49a
is: O14975
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:11001
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC27A2

metaM udpglcur r
is: C00167
is: HMDB00935
is: CHEBI:58052
initial concentration: 1.0
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: UDP-D-glucuronate
has only substance units: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR HSD3A1r
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
type: Reaction

metaM HC00319 m
has only substance units: false
is: CHEBI:30794
type: Species
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_8f0cf9e5_a155_450e_bddb_3dd827404dcb
is: Q15392
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:1718
name: DHCR24
has only substance units: false
initial concentration: NaN

metaM sarcs c
is: C00213
is: HMDB00271
type: Species
boundary condition: false
name: Sarcosine
constant: false
has only substance units: false
is: CHEBI:3513
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110029#_95fd05a7_8a34_4258_9579_c18ef3746f50
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: _AA203143_1_c
has only substance units: false
is encoded by: hsa:AA203143

metaM o2 x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: SBO:0000247
is: C00007
type: Species
is: HMDB01377
constant: false
has only substance units: false
is: CHEBI:15379

metaR ACONTm
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false

metaR H2Otg
name: H2O transport, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000

metaR NDPK1n
reactant: MODEL1310110029#
is described by: ECO:0000134
modifier: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reversible: true
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is: SBO:0000176
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM glu L c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:29985
is: HMDB00148
constant: false
initial concentration: 1.0
type: Species
name: L-glutamate(1-)
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

metaM itp e
is: HMDB00189
constant: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
name: ITP(3-)
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR r0407
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
reactant: MODEL1310110029#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
fast: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_32b98207_7983_46ba_9c2b_b400aaa03332
initial concentration: NaN
is: P28331
type: Species
initial amount: NaN
name: NDUFS1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4719
boundary condition: true
constant: false

metaM 3pg c
is: http://identifiers.org/pubchem.compound/3497
is: C00197
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:58272
boundary condition: false
has only substance units: false
name: 3-Phospho-D-glycerate
is: HMDB00807
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_0002f6b1_fc88_495b_ba6b_5aa2a66cb7b1
name: ALG5
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29880
is: Q9Y673
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_4a994b36_e2ef_4d2e_af36_eeaa0ace9e58
is encoded by: hsa:AU149534
name: _AU149534_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_35a5a2f9_51f8_4467_bbb9_dadb7de94039
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P23434
name: GCSH
boundary condition: true
is encoded by: hsa:2653
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9a16c747_1ff8_4b58_8ebc_a53c1007d72b
boundary condition: true
has only substance units: false
is: Q6NVC0
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC25A5
is encoded by: hsa:292

metaR NDPK1m
reactant: MODEL1310110029#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM pa hs g
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57739
name: phosphatidate(2-)
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
has only substance units: false

metaR r1650
fast: false
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#

metaR r0340
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
modifier: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#

metaR r0051
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7

http://identifiers.org/biomodels.db/MODEL1310110029#_23417f5d_8c22_49f3_8a7b_20c2c3283fe7
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: B4DZR2
has only substance units: false
constant: false
boundary condition: true
name: ALDH1A2
is encoded by: hsa:8854

metaR r0408
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.3.5
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110029#
reversible: true

metaR HIStiDF
name: L-histidine transport via diffusion (extracellular to cytosol)
reversible: false
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_7c5aeb1d_a557_4007_8d7c_3e08865b4af8
has only substance units: false
name: PRDX1
is encoded by: hsa:5052
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR FUMAC
is: SBO:0000176
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.7.1.2
product: MODEL1310110029#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
name: fumarylacetoacetase

http://identifiers.org/biomodels.db/MODEL1310110029#_746ec363_b3a8_49db_95f9_8088b1ebad19
has only substance units: false
is encoded by: hsa:AI539321
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110029#_4ad1f28a_4878_489a_b16e_402599b1b168
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: LIPC
type: Species
is: A6H8L5
is encoded by: hsa:3990

http://identifiers.org/biomodels.db/MODEL1310110029#_f102f7b9_9bec_4d02_9d41_f06b6c3622a1
is: SBO:0000252
constant: false
is encoded by: hsa:AA788780
initial concentration: NaN
name: _AA788780_1_c
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR PI45P5P
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is: SBO:0000176
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR NADHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
name: NADH transporter, endoplasmic reticulum
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false

metaR NAHCO3 HCLt
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
is: SBO:0000185
is described by: ECO:0000269

metaR r2131
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true
fast: false
modifier: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaR r1651
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r2201
modifier: MODEL1310110029#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
fast: false

metaR r1147
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110029#

metaM tststerone r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
name: testosterone
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17347
has only substance units: false
is: HMDB00234
is: SBO:0000247

metaM ppbng c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: Porphobilinogen
type: Species
is: C00931
is: CHEBI:58126
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: HMDB00245

metaM glu L e
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
boundary condition: false
is: CHEBI:29985
is: HMDB00148
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR RE1447N
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is: SBO:0000176
name: RE1447
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_af24102e_67df_4f83_9ece_1bb482c36408
is encoded by: hsa:AW299740
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _AW299740_1_m

http://identifiers.org/biomodels.db/MODEL1310110029#_c4a7d9f5_af02_4314_a22f_11c790a6bc7c
type: Species
is encoded by: hsa:AI469183
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI469183_1_x
initial amount: NaN
boundary condition: true

metaR LEUKTRF4t
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
name: leukotriene F4 transport
reactant: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_2570bd5e_b2a2_4897_be11_8daeff989191
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:221823
initial amount: NaN
name: PRPS1L1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c5647890_b68e_4179_8fbd_5a037cfe11af
constant: false
initial amount: NaN
boundary condition: true
name: FOLR3
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q05C14
is encoded by: hsa:2352

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaR r2080
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM 3sala c
initial concentration: 1.0
is: CHEBI:61085
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: C00606
name: 3-Sulfino-L-alanine

metaR r2130
kinetic law: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM arachd e
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: HMDB01043
is: CHEBI:32395
name: arachidonate
constant: false
initial concentration: 1.0

metaR RAtn3
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
name: 13-cis-retinoic acid transport, nuclear
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
fast: false

metaR NDPK2n
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
fast: false
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true

metaM retinol c
name: retinol
has only substance units: false
is: CHEBI:50211
is: HMDB00305
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
boundary condition: false
type: Species

metaR r1652
modifier: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR r2202
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110029#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110029#
is described by: ECO:0000000

metaR DSAT
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: dihydrosphingosine N-acyltransferase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
type: Reaction

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_8435348d_0f45_4591_9baa_3ec571414165
is: SBO:0000252
boundary condition: true
name: _AI620219_1_e
constant: false
is encoded by: hsa:AI620219
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR UMPK2n
is described by: ECO:0000269
name: UMP kinase (CTP),nuclear
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176

metaM nadph r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
is: HMDB00221
is: CHEBI:57783
is: SBO:0000247
constant: false
is: C00005
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c6cf10c1_80b2_4490_967a_8c1af790c396
has only substance units: false
name: _AA081045_1_m
initial amount: NaN
type: Species
is encoded by: hsa:AA081045
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM 3snpyr c
boundary condition: false
initial concentration: 1.0
name: 3-Sulfinopyruvate
is: HMDB02332
is: CHEBI:1665
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_65bc602b_2d87_4138_9009_6dc72705a75d
name: GSTZ1
is encoded by: hsa:2954
type: Species
is: O43708
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM ibcoa m
constant: false
type: Species
initial amount: NaN
is: CHEBI:57338
boundary condition: false
is: HMDB01243
name: isobutyryl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
initial concentration: 1.0

metaR r2081
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_dd6a34d8_4c58_45ea_bf8c_05baf3e55389
has only substance units: false
boundary condition: true
name: CA14
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:23632
constant: false
initial concentration: NaN
is: A8K3J4

metaR r0801
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6d7c9613_a2a4_47a2_b566_34eeea6ee261
constant: false
is: SBO:0000252
is encoded by: hsa:195814
initial amount: NaN
boundary condition: true
has only substance units: false
is: B3KT84
initial concentration: NaN
name: SDR16C5
type: Species

metaR r1653
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR CYTK13
reversible: true
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
fast: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_2ee5b9f5_4ae9_4666_acea_51b622bb904a
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: CPT1B
is: E9PCP2

http://identifiers.org/biomodels.db/MODEL1310110029#_1b79f904_3ba6_4103_a094_0bffc04099a8
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: IDH2
boundary condition: true
is: SBO:0000252
is: P48735
type: Species
is encoded by: hsa:3418
constant: false

metaR r2133
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110029#

metaM 4abutn m
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58264
name: 4-ammoniobutanal
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_685cea55_2849_4626_af83_4b2c4e3ec6e8
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:22305
boundary condition: true
name: _22305_2_c
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_93c9589b_5514_4d50_ada5_995079eb43bd
is encoded by: hsa:4645
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: Q9H6Y6
name: MYO5B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_2e73c0df_847f_48bb_ab66_1d0be53745ea
name: MECR
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51102
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110029#_fc4c77ee_c1cc_4bac_bec9_55dd7caa191a
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: PLCE1
has only substance units: false
boundary condition: true
is encoded by: hsa:51196
is: Q9P212

metaR ACALDtm
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
reversible: true
name: acetaldehyde mitochondrial diffusion
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_67c62dd2_698f_48f6_8e9b_988092800ff7
constant: false
type: Species
has only substance units: false
name: _AA177072_1_c
is encoded by: hsa:AA177072
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR O2Stn
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
name: superoxide anion transport via diffusion (nucleus)

http://identifiers.org/biomodels.db/MODEL1310110029#_26ad2c2e_fe03_48db_8136_d87a0d6c1971
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q99884
has only substance units: false
constant: false
boundary condition: true
name: SLC6A7
is encoded by: hsa:6534

metaM retinol e
initial concentration: 1.0
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
constant: false
is: SBO:0000247
name: retinol
initial amount: NaN
is: CHEBI:50211
is: HMDB00305
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9d9a0c21_4019_4fc7_be79_da3553feead5
is: B4DIA3
constant: false
name: SLC6A8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6535
type: Species
boundary condition: true

metaR CYTK14
is described by: ECO:0000269
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110029#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e5bad998_ef9d_44c5_ba73_965bff9eabb0
name: INPPL1
initial concentration: NaN
has only substance units: false
is: O15357
is encoded by: hsa:3636
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM fadh2 r
has only substance units: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
is: CHEBI:58307
constant: false
initial concentration: 1.0
is: HMDB01197
name: FADH2(2-)
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f8e194bd_4906_4ec6_a407_39070c7c759a
is: SBO:0000252
is encoded by: hsa:8034
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC25A16
is: P16260

metaM HC00319 c
name: Malonate
is: CHEBI:30794
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1654
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Active transport

metaR r2132
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM arachd c
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01043
is: CHEBI:32395
name: arachidonate
has only substance units: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR r2200
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM taur c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
type: Species
boundary condition: false
is: C00245
is: CHEBI:3544
is: SBO:0000247
is: HMDB00251
name: Taurine
constant: false
has only substance units: false

metaR biomass reaction
is described by: ECO:0000134
product: MODEL1310110029#
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110029#
name: biomass_reaction
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:

metaM pa hs c
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
boundary condition: false
has only substance units: false
constant: false
name: phosphatidate(2-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GLCt4
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110029#
is: SBO:0000185
name: glucose transport via sodium symport
fast: false

metaM didp c
constant: false
initial concentration: 1.0
is: CHEBI:28823
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
initial amount: NaN
name: dIDP
is: SBO:0000247
is: HMDB03536
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_f49eef42_92e4_4ac9_a2b9_a03ceef899cb
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC25A10
initial amount: NaN
is encoded by: hsa:1468
is: Q9UBX3
constant: false

metaR r1928
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
type: Reaction

metaR r1655
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM Rtotal2 c
type: Species
is: SBO:0000247
name: R total 2 position
is: C00055
is: CHEBI:60377
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: HMDB00095
constant: false
initial concentration: 1.0
initial amount: NaN

metaM succ x
initial concentration: 1.0
boundary condition: false
is: HMDB00254
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
is: SBO:0000247
constant: false
is: C00042
is: CHEBI:30031
has only substance units: false
name: Succinate

metaR MI145PK
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.127
kinetic law: MODEL1310110029#
name: inositol-1,4,5-trisphosphate 3-kinase
modifier: MODEL1310110029#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reactant: MODEL1310110029#
type: Reaction

metaR O2Stm
reversible: true
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110029#_e112aa3a_6436_4a5d_bbf7_ac1b466efaf8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI024818
type: Species
name: _AI024818_1_c
initial amount: NaN
constant: false

metaR H2Otm
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110029#
name: H2O transport, mitochondrial
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000185

metaM itp c
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57614
constant: false
boundary condition: false
initial concentration: 1.0
name: ITP(3-)
is: SBO:0000247

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM paps g
initial concentration: 1.0
is: HMDB01134
has only substance units: false
is: CHEBI:58339
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR r1656
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RBTt
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110029#
name: ribitol transport via passive diffusion
is: SBO:0000185
reversible: false

metaM taur e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00245
type: Species
is: SBO:0000247
is: CHEBI:3544
boundary condition: false
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
name: Taurine

metaR GACMTRc
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.2
is described by: ECO:0000269
name: guanidinoacetate N-methyltransferase (c)
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_341a722e_b087_44ef_b411_5f797097290e
has only substance units: false
boundary condition: true
name: SLC7A5
is: SBO:0000252
is encoded by: hsa:8140
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q8IV97

http://identifiers.org/biomodels.db/MODEL1310110029#_7a6a4dab_6c7d_4830_848f_1672c8eb96fc
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC36A1
has only substance units: false
boundary condition: true
is encoded by: hsa:206358
is: Q1LZ56
constant: false

metaR CYANtm
product: MODEL1310110029#
type: Reaction
name: Cyanide transport via diffusion (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM 7thf e
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: HMDB06559
initial concentration: 1.0
name: heptaglutamyl folate (THF)
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_14f36884_fa08_4f7f_abd7_f72e66952681
is: Q96NR8
name: RDH12
initial concentration: NaN
is encoded by: hsa:145226
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_42f3ef74_1bd7_4720_bbab_412455797829
name: PPA2
has only substance units: false
is: Q9H2U2
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27068
type: Species
constant: false

metaM mal L c
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
is: CHEBI:15589
name: (S)-malate(2-)

metaR RE0944E
is: SBO:0000176
reversible: true
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
name: RE0944
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR H2Otn
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: H2O transport, nuclear
product: MODEL1310110029#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110029#

metaM gdpmann c
initial amount: NaN
constant: false
is: HMDB01163
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: CHEBI:57527
has only substance units: false
name: GDP-alpha-D-mannose(2-)
type: Species
initial concentration: 1.0

metaR H2Otp
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR ETOHt
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
name: ethanol reversible transport
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_91b747e5_fe54_461b_bc9c_f97c59dcfdd1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:LOC728997
type: Species
name: _LOC728997_1_c
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR DITPtn
is: SBO:0000185
fast: false
name: dITP nuclear transport
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_960e45c9_a26c_474f_b6e1_16ae12e12aa5
name: ENPP1
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: P22413
is encoded by: hsa:5167
is: SBO:0000252
initial concentration: NaN

metaR 5ADTSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
name: sulfonated testosterone transport
kinetic law: MODEL1310110029#
reversible: true

metaM HC02214 c
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: prostaglandin-f1alpha
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_4374e82d_ddf2_4782_b597_f42687f2077b
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5332
initial concentration: NaN
has only substance units: false
is: E2QRH8
boundary condition: true
type: Species
name: PLCB4

metaR r2136
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reversible: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
type: Reaction

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM andrstandn r
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN
type: Species
is: HMDB00899
name: 5alpha-androstane-3,17-dione
is: CHEBI:15994
has only substance units: false
constant: false
initial concentration: 1.0

metaR r1646
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
reversible: true

metaR RE2349C
name: RE2349
reactant: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_fa6a923f_a821_4eab_b495_6207bfdaa52e
is: SBO:0000252
is: O75907
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8694
constant: false
has only substance units: false
initial amount: NaN
name: DGAT1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a9b4f223_7c66_45d4_859f_4702980e4366
is: SBO:0000252
constant: false
is: P14618
is encoded by: hsa:5315
initial amount: NaN
boundary condition: true
name: PKM2
type: Species
has only substance units: false
initial concentration: NaN

metaM nadph m
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57783
is: HMDB00221
is: SBO:0000247

metaM CE0785 m
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: C01936
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false

metaR DCMPDA
type: Reaction
name: dCMP deaminase
fast: false
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
product: MODEL1310110029#
is described by: ECO:0000254
kinetic law: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.12

metaR r2137
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_408ef77d_c679_46fa_a546_c4541890c5a3
initial concentration: NaN
is encoded by: hsa:4731
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: P56181
name: NDUFV3
initial amount: NaN
has only substance units: false

metaR r1645
is described by: ECO:0000000
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
fast: false
type: Reaction
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_6fae5f47_0e1a_4f6e_8754_b64c2f32474d
has only substance units: false
type: Species
is encoded by: hsa:AI348006
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: _AI348006_1_c
initial concentration: NaN

metaM itp n
name: ITP(3-)
boundary condition: false
is: CHEBI:57614
constant: false
is: SBO:0000247
is: HMDB00189
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_32ddcc1b_a1b3_48c0_a9a4_b51d58d1a6b4
is: Q9Y6L6
name: SLCO1B1
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10599
has only substance units: false

metaM 4mop c
boundary condition: false
initial amount: NaN
is: CHEBI:17865
constant: false
is: HMDB00695
type: Species
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0

metaM HC02214 e
initial amount: NaN
name: prostaglandin-f1alpha
initial concentration: 1.0
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
boundary condition: false
is: CHEBI:28852
type: Species
is: SBO:0000247

metaR NDP7ex
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
is described by: ECO:0000269
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (UDP), extracellular
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_04fe2509_1e25_417a_b618_e999d092e9a9
name: _BE966236_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:BE966236
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM glc D c
is: HMDB00122
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:4167
constant: false
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110029#_4fd6e597_b8ec_4179_b242_f280d4302a29
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA977580
constant: false
name: _AA977580_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR r1648
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_76dc3f0b_1e02_4daf_99c1_67611a055e3a
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: HSD17B4
constant: false
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110029#_1dd49872_c356_4876_bd0c_6c02c90b7458
initial amount: NaN
name: GAPDHS
is encoded by: hsa:26330
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: O14556

metaR r0885
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM fald c
type: Species
is: CHEBI:16842
name: formaldehyde
boundary condition: false
is: HMDB01426
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
has only substance units: false

metaR r2407
reversible: false
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaM ac m
has only substance units: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: acetate
is: HMDB00042
initial concentration: 1.0
is: CHEBI:30089

metaR COAtr
reversible: true
reactant: MODEL1310110029#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110029#
name: COA transporter, endoplasmic reticulum

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_fef5bec8_1ade_44e4_8f34_5a300432d4ba
has only substance units: false
name: ADHFE1
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:137872
initial concentration: NaN
is: Q8IWW8
is: SBO:0000252

metaR r1291
type: Reaction
kinetic law: MODEL1310110029#
name: Postulated transport reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000185
product: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_7f8ab67d_4605_4d9c_aa60_eabaa968f002
initial concentration: NaN
name: _AI818585_1_c
boundary condition: true
is encoded by: hsa:AI818585
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR DM fol
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_b1d4a633_8ad9_44c1_bf58_21e4e1c09b81
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: SDHA
is: P31040
is encoded by: hsa:6389
initial concentration: NaN
is: SBO:0000252
type: Species

metaR PEAMNO
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Phenethylamine oxidase
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR TRIODTHYt2
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: true
type: Reaction
fast: false
name: T3 transport via facilitated diffusion

metaM nadh r
constant: false
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57945
type: Species
is: HMDB01487
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_c2a72f5f_7453_40b2_9438_69668d56553d
constant: false
is encoded by: hsa:8803
has only substance units: false
initial amount: NaN
name: SUCLG1:SUCLA2
has part: E5KS60
boundary condition: true
type: Species
is: SBO:0000297
initial concentration: NaN

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR r1647
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR r2139
modifier: MODEL1310110029#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r0655
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
reversible: true
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

metaR RE2677G
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
name: RE2677
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
reversible: false
is described by: ECO:0000000

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_23b4bf39_66a5_4ae3_88dd_8036fa6a3a04
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2687
boundary condition: true
name: GGT5
is: P36269
constant: false
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_7948bfff_f6bb_486a_b860_e52b97a78d5a
is: SBO:0000252
boundary condition: true
name: H6PD
constant: false
is: O95479
is encoded by: hsa:9563
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_36d2db7e_07b5_4cbe_9f7f_8bf2a25b074f
constant: false
boundary condition: true
name: NDUFS3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O75489
initial amount: NaN
is encoded by: hsa:4722
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_0d49d091_e76d_4945_95a0_180fad7172b6
initial amount: NaN
type: Species
name: TUSC3
is encoded by: hsa:7991
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is: Q13454

metaM h x
is: C00080
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
boundary condition: false
is: CHEBI:24636
name: proton
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_dce75349_1a4d_4b4c_a066_4c4ba9242c9f
name: PPA2
is: SBO:0000252
constant: false
is encoded by: hsa:27068
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r1649
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110029#
reversible: true
fast: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR COAtp
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: coenzyme A transport, peroxisomal
kinetic law: MODEL1310110029#

metaM HC01407 m
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28276
boundary condition: false
constant: false
name: (S)-Hydroxyhexanoyl-CoA
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_b6ce2546_56cb_4aa6_846c_61b604cd432b
constant: false
is: P05091
name: ALDH2
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:217

http://identifiers.org/biomodels.db/MODEL1310110029#_3318f328_baa3_40fa_9d5a_9a81a87e2606
is: Q9UEF7
initial amount: NaN
boundary condition: true
name: KL
is: SBO:0000252
is encoded by: hsa:9365
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM HC00591 m
name: 2-oxoglutaramate
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16769
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_41893b28_6c6b_4bdc_bc05_804bd645bdac
is: Q86VV3
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:953
name: ENTPD1
boundary condition: true
initial amount: NaN

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r1871
modifier: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_2e3fc236_d97d_4ae9_ab95_9570cb521a93
type: Species
boundary condition: true
is encoded by: hsa:1371
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: CPOX
initial amount: NaN
is: P36551
constant: false

metaM nadh x
constant: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57945
has only substance units: false
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110029#_1f0bd06f_d8d6_4bc2_be56_988f3c1e41af
name: COX7A2L
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9167
is: Q6FGA0
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_24e253f4_82c4_4f5e_bf0f_189243b36e80
boundary condition: true
name: _T83654_1_c
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:T83654
type: Species

metaR COAtm
kinetic law: MODEL1310110029#
name: CoA transporter
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110029#
product: MODEL1310110029#

metaR RE2677E
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
name: RE2677
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110029#_f63b9485_2397_4439_8e95_5add86e6e43d
constant: false
is encoded by: hsa:AV717590
type: Species
boundary condition: true
has only substance units: false
name: _AV717590_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: false
name: fatty-acid--CoA ligase (tetradecanoate)
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_37154db7_d6ee_4c3c_a606_30d4a9226618
is: SBO:0000252
name: _T83654_1_m
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:T83654

metaR C40CPT1
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR r1588
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM didp n
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: dIDP
type: Species
is: CHEBI:28823
is: SBO:0000247
constant: false
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaR RETI3
is: SBO:0000176
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
name: retinol isomerase (13-cis)
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
is described by: ECO:0000000

metaR COAtn
reactant: MODEL1310110029#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: coenzyme A transport, nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a5003b4a_60ca_43ca_bedd_bb3eb54bba7b
initial concentration: NaN
is: P04075
initial amount: NaN
boundary condition: true
name: ALDOA
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:226

http://identifiers.org/biomodels.db/MODEL1310110029#_6e6f81f8_5a19_4627_9987_a56d4f3692a9
boundary condition: true
name: ALDH6A1
initial concentration: NaN
initial amount: NaN
is: Q02252
constant: false
is encoded by: hsa:4329
is: SBO:0000252
has only substance units: false
type: Species

metaM CE2435 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
type: Species
name: trans,cis-deca-2,4-dienoyl-CoA
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
is: C01936
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_679bf7cc_bea1_4258_89b6_51dcb060d6b2
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI345944_1_m
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI345944

http://identifiers.org/biomodels.db/MODEL1310110029#_d49f87cc_4c00_4759_b52f_0ab640d56814
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:51179
boundary condition: true
has only substance units: false
name: HAO2
initial concentration: NaN
is: SBO:0000252

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
fast: false
reversible: true
kinetic law: MODEL1310110029#
type: Reaction

metaR STS1
name: Steryl-sulfatase
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a8df1eaa_d88b_42fb_b3a3_5d77f031b4c8
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI656480
initial concentration: NaN
name: _AI656480_1_m

metaM prpncoa m
has only substance units: false
initial amount: NaN
is: CHEBI:57367
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
is: HMDB02307
name: acryloyl-CoA(4-)
constant: false

metaR PROSTGE2t2
product: MODEL1310110029#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: prostaglandin uniport
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
kinetic law: MODEL1310110029#

metaM udpglcur c
type: Species
is: SBO:0000247
has only substance units: false
is: C00167
name: UDP-D-glucuronate
initial amount: NaN
is: HMDB00935
boundary condition: false
is: CHEBI:58052
constant: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0

metaR FALDH
kinetic law: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
name: formaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110029#_2b8a4ce4_86d1_4aa4_9b79_245ab69f376a
is encoded by: hsa:6554
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC10A1
initial concentration: NaN
has only substance units: false
boundary condition: true
is: B2RA41

metaM HC02192 e
is: CHEBI:17179
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
is: SBO:0000247
type: Species
has only substance units: false
name: taurolithocholate
initial concentration: 1.0

metaM lald L c
is: CHEBI:18041
constant: false
boundary condition: false
initial amount: NaN
name: (S)-lactaldehyde
is: SBO:0000247
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_c919d80a_ff33_4d4a_ba74_a895dd86cf20
boundary condition: true
is: Q7GXZ8
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4513
is: SBO:0000252
name: COX2

http://identifiers.org/biomodels.db/MODEL1310110029#_2dff44f5_0e06_4296_b707_4dadd5d0de5e
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: PC
has only substance units: false
is encoded by: hsa:5091
type: Species

metaR RE2814M
name: RE2814
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true

metaM nadph c
boundary condition: false
type: Species
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
is: SBO:0000247
is: HMDB00221
initial amount: NaN
is: C00005
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_700c5293_cf7e_4729_8ab9_7ae2c7608498
has only substance units: false
type: Species
is: P18283
initial amount: NaN
boundary condition: true
name: GPX2
is: SBO:0000252
is encoded by: hsa:2877
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_6af0d508_c72f_4373_9966_e18c60c24b32
name: GPX5
type: Species
is encoded by: hsa:2880
has only substance units: false
is: O75715
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaR r1586
reversible: true
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_e3c68b84_16c9_4a28_b52a_c3d1493a8c47
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: FDFT1
is encoded by: hsa:2222
type: Species
is: P37268
initial amount: NaN

metaR r2357
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110029#

metaM CE1926 e
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00127
name: gama-carboxyethyl-hydroxychroman
boundary condition: false
constant: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR RAI1
product: MODEL1310110029#
is described by: ECO:0000000
name: retinal isomerase (11-cis)
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false

metaR r0549
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.1.1.17
type: Reaction
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/1.6.99.3
is described by: ECO:0000000
is: SBO:0000176

metaR r2511
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
name: Utilized transport
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_8c00b78a_e68e_4299_b862_ef9f82e676cb
is: SBO:0000252
name: NAE1
is encoded by: hsa:8883
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: A8MU28
boundary condition: true

metaR ANTHte
name: Transport of anthranilate
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110029#_4079d458_d90d_4750_bfe9_c42bbca364d8
initial concentration: NaN
name: GGT2
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:728441

metaR r0276
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
product: MODEL1310110029#

metaR GLYAMDTRc
is version of: http://identifiers.org/ec-code/2.1.4.1
fast: false
name: glycine amidinotransferase (c)
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
modifier: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c3aa2a5b_567c_4c2b_a731_a2f3fb2fdc16
type: Species
initial concentration: NaN
is: Q15147
constant: false
name: PLCB4
initial amount: NaN
boundary condition: true
is encoded by: hsa:5332
has only substance units: false
is: SBO:0000252

metaR r2356
kinetic law: MODEL1310110029#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
type: Reaction

metaM lnlccrn c
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: Linoleyl carnitine
is: HMDB06469
is: SBO:0000247
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_d8d59c53_27ab_4d95_bf0e_650c11bf7f38
is encoded by: hsa:29926
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: GMPPA
is: Q96IJ6
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM arachd x
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:32395
initial amount: NaN
is: HMDB01043
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
has only substance units: false
name: arachidonate

metaM HC01111 c
is: SBO:0000247
is: CHEBI:37480
initial concentration: 1.0
name: Galactose-1P
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6?/m1/s1
has only substance units: false

metaR COAtl
fast: false
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: CoA transport in lysosome via diffusion
product: MODEL1310110029#

metaR RAI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
fast: false
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110029#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_dddf3170_e3df_4458_8002_2e925de956c5
has only substance units: false
is encoded by: hsa:3098
type: Species
constant: false
name: HK1
boundary condition: true
initial concentration: NaN
is: Q59FD4
initial amount: NaN
is: SBO:0000252

metaR PTPATe
reactant: MODEL1310110029#
fast: false
type: Reaction
kinetic law: MODEL1310110029#
name: PTPATe
product: MODEL1310110029#
is described by: ECO:0000134
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR DURAD2
kinetic law: MODEL1310110029#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)

metaR r2510
name: Utilized transport
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110029#
fast: false

metaR RETH2e
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (11-cis), extracellular
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d5bcfebd_ebf9_43f9_9f07_74ff5ec408f9
is: SBO:0000252
name: _AA614647_1_c
initial concentration: NaN
is encoded by: hsa:AA614647
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR MGSA2
kinetic law: MODEL1310110029#
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110029#
name: methyglyoxylate synthase 2 (from g3p)
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD

metaR r1584
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
product: MODEL1310110029#

metaR PGDI
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.5.1.18
is version of: http://identifiers.org/ec-code/5.3.99.2
reversible: true
is: SBO:0000176
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR r2355
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#

metaR r0998
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110029#
fast: false
is: SBO:0000185

metaR GLYCTO1p
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.3.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_226f7646_f6be_40bf_a466_075ddb38e2e8
initial concentration: NaN
type: Species
is: P09417
constant: false
is encoded by: hsa:5860
name: QDPR
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false

metaM arab L c
name: L-arabinose
type: Species
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:30849
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_89b008f0_22da_4944_bc3b_517213b24c78
initial concentration: NaN
is encoded by: hsa:5169
initial amount: NaN
boundary condition: true
is: Q308M7
constant: false
is: SBO:0000252
type: Species
name: ENPP3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_78bc87c9_9b10_4504_914e_be92195ddcb4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:205
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: AK4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_8d91bb47_968e_4fe6_bf52_3d5b9ca0c6ea
constant: false
name: SLC6A10P
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:386757
type: Species
has only substance units: false
is: SBO:0000252

metaR r1585
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction

metaM h r
has only substance units: false
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
initial concentration: 1.0
name: proton
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaR r2354
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_b66c2fb7_e45e_467c_8305_8712db6952a5
type: Species
initial concentration: NaN
is encoded by: hsa:BF195998
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: _BF195998_1_x

metaM pchol hs g
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Phosphatidylcholine
is: CHEBI:16110
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

http://identifiers.org/biomodels.db/MODEL1310110029#_7fd2f97d_df31_43dd_9696_04b669db8774
is: P31645
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:6532
name: SLC6A4
is: SBO:0000252
constant: false

metaR r0129
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_043bc0c6_cff1_469e_a543_dcefa60df24f
initial concentration: NaN
name: HGD
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3081
type: Species
constant: false
initial amount: NaN
is: Q93099
has only substance units: false

metaR r0999
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110029#
name: Facilitated diffusion
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_9f580f01_0198_4596_8918_59b56464cbd1
has only substance units: false
type: Species
is: SBO:0000252
is: O00746
initial concentration: NaN
name: NME4
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4833

metaM dc2coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: trans-Dec-2-enoyl-CoA
type: Species
is: CHEBI:61406
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_23da8c5a_1392_447b_b041_b6e8602be564
initial amount: NaN
has only substance units: false
is: Q9BZV2
name: SLC19A3
boundary condition: true
is encoded by: hsa:80704
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaR GALSIDEtg
name: galactocerebroside intracellular transport
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c0ee621a_4f32_4b3f_9143_cb401a03d9a9
constant: false
type: Species
is: SBO:0000252
name: SLC24A4
is encoded by: hsa:123041
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM 4mop m
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
is: CHEBI:17865
is: HMDB00695
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
initial amount: NaN

metaR r0545
is: SBO:0000176
type: Reaction
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is described by: ECO:0000000

metaR r2058
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_58562f44_4ea8_49b2_b472_24726b018b2e
has only substance units: false
boundary condition: true
is encoded by: hsa:4710
constant: false
name: NDUFB4
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O95168

metaM glc D e
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: D-glucose
boundary condition: false
is: CHEBI:4167
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_1b615bdd_2c39_4aff_b410_f7a5baf697ee
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:377841
is: Q5MY95
constant: false
name: ENTPD8
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_55f6d667_4484_4358_8766_4f03b8611557
initial amount: NaN
name: HMOX2
boundary condition: true
is: P30519
is encoded by: hsa:3163
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_1352d168_de69_4d67_94de_18f0a8936b0a
is: SBO:0000252
type: Species
constant: false
is: B4DK61
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACOX1
is encoded by: hsa:51
initial concentration: NaN

metaM arab L e
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
name: L-arabinose
is: HMDB00646
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:30849

metaM hxan c
is: HMDB00157
is: SBO:0000247
is: CHEBI:17368
has only substance units: false
type: Species
name: Hypoxanthine
boundary condition: false
initial amount: NaN
is: C00262
initial concentration: 1.0
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262

http://identifiers.org/biomodels.db/MODEL1310110029#_91ed8a97_1d80_440e_8eec_f631b092b967
has only substance units: false
is: P42765
is encoded by: hsa:10449
name: ACAA2
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d6be3eed_a6a2_4a14_9ec2_e07710915df6
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: GPT
type: Species
is encoded by: hsa:2875
initial amount: NaN
has only substance units: false
is: P24298

metaM oh1 c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO CHARGE: -1
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01039
constant: false
is: C01328
name: hydroxide ion

metaR r0915
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110029#_4625247e_e111_4297_a073_4cede85bd9cc
has only substance units: false
initial concentration: NaN
is: C9JT23
boundary condition: true
name: NDUFA11
is encoded by: hsa:126328
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_9458da54_5a15_4ee6_9e8e_56456f317f68
initial amount: NaN
is: SBO:0000252
name: PAPSS2
has only substance units: false
is encoded by: hsa:9060
initial concentration: NaN
is: O95340
boundary condition: true
type: Species
constant: false

metaR PE HStm
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: phosphatidylethanolamine scramblase

metaR r0993
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d516b8f0_cfb0_4b99_ba1b_074065950292
initial concentration: NaN
is encoded by: hsa:1339
has only substance units: false
is: Q02221
type: Species
initial amount: NaN
name: COX6A2
constant: false
is: SBO:0000252
boundary condition: true

metaR RE2814R
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
name: RE2814
type: Reaction
kinetic law: MODEL1310110029#
reversible: true

metaR r0127
reversible: false
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_cc1a010a_dfcd_4394_a1c5_29e1d4617448
type: Species
is: O75251
is: SBO:0000252
initial amount: NaN
name: NDUFS7
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:374291

metaM leuktrC4 e
initial concentration: 1.0
is: SBO:0000247
is: HMDB01198
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57973
name: leukotriene C4(2-)
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM dhcholestanate c
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
is: HMDB00359
constant: false
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
is: CHEBI:16577
initial concentration: 1.0

metaR r1583
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_9253ed09_b4c5_4dfc_930a_708447137c07
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI222095
initial concentration: NaN
name: _AI222095_1_e
constant: false
type: Species
has only substance units: false

metaR TRPO2
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
is described by: ECO:0000269
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.11
type: Reaction
is: SBO:0000176

metaR r2079
modifier: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM fadh2 c
has only substance units: false
name: FADH2(2-)
constant: false
boundary condition: false
is: HMDB01197
is: SBO:0000247
initial amount: NaN
is: CHEBI:58307
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_83509aa4_e927_45f2_8aa2_76e57c05cd23
initial amount: NaN
is encoded by: hsa:218
name: ALDH3A1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: P30838
is: SBO:0000252
boundary condition: true

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaM lgt S c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57474
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1

metaM arachdcoa c
has only substance units: false
type: Species
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
initial amount: NaN
is: CHEBI:57368
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_967e98b6_449b_44e9_a117_7a5df44d6643
constant: false
type: Species
is encoded by: hsa:7167
name: TPI1
boundary condition: true
initial amount: NaN
is: Q53HE2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r0410
is described by: ECO:0000000
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110029#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR r2359
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110029#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR r0994
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
reversible: true
name: Facilitated diffusion

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM 7dhchsterol r
is: CHEBI:17759
type: Species
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: cholesta-5,7-dien-3beta-ol
is: HMDB00032
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_cb556088_7505_4fae_a61b_84c270a8cee6
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: ND4
is encoded by: hsa:4538
initial amount: NaN
is: P03905
boundary condition: true
constant: false

metaR r1580
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110029#

metaM HC02192 c
is: CHEBI:17179
constant: false
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: taurolithocholate
type: Species
boundary condition: false

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: hydroxide ion
is: C01328
type: Species
boundary condition: false
is: HMDB01039

metaM hxan e
has only substance units: false
type: Species
name: hypoxanthine
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00157
is: SBO:0000247
is: CHEBI:17368

metaM tchola x
constant: false
name: taurocholate
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36257
is: HMDB00036

metaR THRGLNexR
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110029#

metaR r0913
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
type: Reaction
reversible: true
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM h n
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
type: Species
boundary condition: false
is: CHEBI:24636

metaR r2358
product: MODEL1310110029#
is: SBO:0000185
fast: false
reactant: MODEL1310110029#
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_87bae9dc_bab6_45c8_a3d8_0a022208fde5
has only substance units: false
initial amount: NaN
is encoded by: hsa:9057
name: SLC7A6
is: Q92536
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaR r0339
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
kinetic law: MODEL1310110029#

metaR RE1898C
reversible: true
name: RE1898
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
type: Reaction

metaM pchol hs c
name: Phosphatidylcholine
has only substance units: false
initial concentration: 1.0
is: CHEBI:16110
initial amount: NaN
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247

metaM leuktrC4 c
initial concentration: 1.0
is: SBO:0000247
is: HMDB01198
type: Species
has only substance units: false
initial amount: NaN
name: leukotriene C4(2-)
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
constant: false

metaR r1581
fast: false
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5c41e8cf_2563_4b33_af73_0762b7be0184
constant: false
initial amount: NaN
is encoded by: hsa:6578
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLCO2A1
is: SBO:0000252
is: Q92959

http://identifiers.org/biomodels.db/MODEL1310110029#_d016f18c_b091_4622_ad98_68f99a4b2ed4
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:23057
name: NMNAT2
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM mi145p c
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: CHEBI:203600
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
has only substance units: false
is: HMDB01498
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaR RE0512M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512

metaR ASCBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
name: L-ascorbate transport via facilitated diffusion
type: Reaction
reversible: true

metaM arachd r
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:32395
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
is: HMDB01043
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_42f250a9_3612_4785_9c25_93fb58b8b072
name: NDUFA2
type: Species
is: SBO:0000252
is: O43678
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4695
constant: false

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM 34dhmald c
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903
is: HMDB06242
is: C05577
is: SBO:0000247
constant: false
initial amount: NaN

metaM mlthf c
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15636
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
is: C00143
is: HMDB01533
has only substance units: false

metaR 2MCITt
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
name: 2-methylcitrate transport via diffusion
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a2b6b81c_b65e_442b_b5fc_3c93677e6ef2
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACAA1
is: Q96CA6
is encoded by: hsa:30
constant: false
initial amount: NaN
initial concentration: NaN

metaR GLUDxm
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: glutamate dehydrogenase (NAD) (mitochondrial)

metaM msa m
boundary condition: false
initial concentration: 1.0
constant: false
name: 3-oxopropanoate
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: CHEBI:33190

http://identifiers.org/biomodels.db/MODEL1310110029#_15830851_5e96_4155_9897_1a61818490aa
has only substance units: false
type: Species
is encoded by: hsa:3612
constant: false
boundary condition: true
name: IMPA1
initial concentration: NaN
is: B7Z6Q4
initial amount: NaN
is: SBO:0000252

metaR FUMSO3tm
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_54a84366_24fc_4c1c_87ff_64b7c2d87787
boundary condition: true
initial amount: NaN
type: Species
is: P31040
initial concentration: NaN
constant: false
has only substance units: false
name: SDHA
is encoded by: hsa:6389
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_add7d222_94d1_4eaf_ab97_c4889e87dc2c
has only substance units: false
name: MBOAT2
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:129642
type: Species
is: Q6ZWT7
initial concentration: NaN
is: SBO:0000252

metaM dgtp c
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
boundary condition: false
is: CHEBI:16497
is: HMDB01440
name: dGTP
initial amount: NaN
type: Species
is: C00286

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
name: cholesterol intracellular transport
reversible: true
fast: false
product: MODEL1310110029#

metaR r0085
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7084f954_1e2d_4f67_9a23_dec38599ef25
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: OGDH
initial concentration: NaN
is encoded by: hsa:4967
constant: false
initial amount: NaN
is: Q02218

metaR BILIRUBt2
reversible: true
is described by: ECO:0000269
fast: false
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
modifier: MODEL1310110029#

metaR LEUt5m
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
name: leucine mitochondrial transport
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM rib D c
type: Species
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00283
is: CHEBI:16988
constant: false
name: D-ribose

http://identifiers.org/biomodels.db/MODEL1310110029#_e2508deb_2384_4f69_b52d_48d310f4446f
is: SBO:0000252
boundary condition: true
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaM HC01406 m
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28264
boundary condition: false
name: 3-Oxooctanoyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5ae2f005_fc54_4eff_9328_9e36dae1a723
boundary condition: true
is encoded by: hsa:126
name: ADH1C
type: Species
constant: false
is: P00326
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM accoa n
name: acetyl-CoA(4-)
is: HMDB01206
is: CHEBI:57288
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f95e5ea7_e323_4b60_bee7_babd20b026fb
is encoded by: hsa:206
boundary condition: true
name: _206_1_c
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM bilirub c
constant: false
initial concentration: 1.0
name: bilirubin(2-)
is: CHEBI:57977
boundary condition: false
is: HMDB00054
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM dhea r
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
initial amount: NaN
type: Species
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
is: HMDB00077
is: CHEBI:28689
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR CHSTEROLt1
product: MODEL1310110029#
is described by: ECO:0000304
reactant: MODEL1310110029#
type: Reaction
fast: false
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
modifier: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_80c51411_694d_48c1_9926_b55294d4c759
name: _AI285872_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI285872
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_d970af0f_0714_4c8d_a758_8928a1322800
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: Q674R7
is encoded by: hsa:285973
boundary condition: true
is: SBO:0000252
type: Species
name: ATG9B

metaM dhbpt c
has only substance units: false
name: 6,7-dihydrobiopterin
is: CHEBI:20680
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
type: Species
initial concentration: 1.0
initial amount: NaN

metaM 5fthf m
has only substance units: false
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
is: CHEBI:57457
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_2a29d17a_d676_4a7b_8f17_70d6cc81b5fb
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56894
name: AGPAT3
type: Species
is: Q9NRZ7
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR r0086
product: MODEL1310110029#
fast: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110029#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
type: Reaction

metaR r1453
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
product: MODEL1310110029#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8

metaR NTD9
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: 5'-nucleotidase (GMP)
reversible: false
is described by: ECO:0000134
product: MODEL1310110029#

metaM retinal cis 13 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 13-cis-retinal
is: CHEBI:45487
constant: false
type: Species
boundary condition: false
is: SBO:0000247

metaM chol m
initial amount: NaN
is: CHEBI:15354
name: choline
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0

metaR FADtru
name: FAD transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a2f2f7a3_7313_479b_89e4_5ee634369ebc
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6524
is: SBO:0000252
type: Species
is: P31639
name: SLC5A2
has only substance units: false
boundary condition: true

metaR CHOLt4
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000269
name: choline, sodium cotransport
fast: false
modifier: MODEL1310110029#

metaR Htr
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: H transporter, endoplasmic reticulum
type: Reaction

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
name: maleylacetoacetate isomerase
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: false
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172
type: Species
name: L-isoleucine
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:17191
constant: false
initial amount: NaN

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_50492b06_2a4b_4518_b870_43a438032047
is: O75874
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:3417
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: IDH1

metaR PIter
is described by: ECO:0000212
reversible: true
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
name: phosphate transport, endoplasmic reticulum

metaR NRPPHRtu
is described by: ECO:0000269
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
name: Norepinephrine uniport
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110029#

metaM rib D e
is: HMDB00283
name: D-ribose
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
is: CHEBI:16988
is: SBO:0000247
boundary condition: false

metaM chol n
name: choline
is: CHEBI:15354
initial amount: NaN
is: SBO:0000247
is: HMDB00097
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR r0083
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110029#

metaM dheas c
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: CHEBI:57905
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01032
type: Species
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM dtdp e
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
initial amount: NaN
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58369
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e0fbc3e7_6cc2_4908_b119_a4d76adc5921
boundary condition: true
is encoded by: hsa:10087
name: COL4A3BP
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9Y5P4

metaR HISyLATthc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR LTC4CP
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
fast: false
name: Leukotriene C4 carboxypeptidase
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110029#

metaR PPBNGS
product: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.24
modifier: MODEL1310110029#
name: porphobilinogen synthase
type: Reaction
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
reversible: false

metaR 34DHPLACOX
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reversible: false
product: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f8fec697_317a_4714_8671_03a71b27a418
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:BG035985
boundary condition: true
name: _BG035985_1_c
initial concentration: NaN

metaR 3MOBte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000134
product: MODEL1310110029#

metaR r1451
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
type: Reaction
is: SBO:0000176
fast: false
name: EC:1.3.3.6
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR CHSTEROLt3
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
product: MODEL1310110029#
name: cholesterol intracellular transport

metaR r0084
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110029#
type: Reaction

metaM orn m
is: CHEBI:46912
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00214
boundary condition: false
constant: false
initial concentration: 1.0
is: C01602
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110029#_3c72e213_450e_4abd_9d64_92bcf1878a76
type: Species
is encoded by: hsa:2678
boundary condition: true
is: P19440
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GGT1
constant: false
is: SBO:0000252

metaM HC02217 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
type: Species
constant: false
is: SBO:0000247
name: prostaglandin-g2
initial amount: NaN
is: CHEBI:27647
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a7d8e57b_ef0a_4fa1_9629_33886d211caa
name: SLC25A1
is encoded by: hsa:6576
type: Species
initial concentration: NaN
is: D9HTE9
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_1c7578cd_0555_42d4_a1bb_40f500dcd9f5
is: Q96T66
initial amount: NaN
is: SBO:0000252
name: NMNAT3
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:349565
boundary condition: true

metaR URIK1
modifier: MODEL1310110029#
is described by: ECO:0000269
name: uridine kinase (ATP:Uridine)
reversible: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.48
is: SBO:0000176
fast: false
type: Reaction

metaM HC02020 r
boundary condition: false
name: Cholesterol-ester-palm
is: CHEBI:3663
type: Species
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

metaM acald c
type: Species
constant: false
boundary condition: false
is: CHEBI:15343
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
name: acetaldehyde
is: SBO:0000247

metaM man6p c
has only substance units: false
is: SBO:0000247
is: CHEBI:17369
initial concentration: 1.0
name: D-Mannose 6-phosphate
initial amount: NaN
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
constant: false
boundary condition: false

metaR UMPKn
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: UMP kinase, nuclear
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5efdcfcf_7838_4b70_ab3f_62dee5b29414
constant: false
boundary condition: true
type: Species
has only substance units: false
is: F6KD01
name: PTEN
is encoded by: hsa:5728
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b98dde67_13dc_45c9_a18e_d3b9b0e0a5af
is encoded by: hsa:594
type: Species
name: BCKDHB
is: P21953
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM cholp c
initial amount: NaN
is: SBO:0000247
is: CHEBI:295975
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
has only substance units: false
type: Species
name: choline phosphate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_8ef3bf29_0350_4b6d_a409_f2cb1f65dfda
is: SBO:0000252
initial amount: NaN
type: Species
name: SDHC
initial concentration: NaN
constant: false
is encoded by: hsa:6391
is: Q99643
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9d1a0cb3_ae29_4218_b1d2_b72704f2b957
name: CA1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:759
is: P00915
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM CE5788 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
name: kinetensin 1-7
is: HMDB02710
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:27485

metaM dtdp c
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:58369
is: SBO:0000247
is: C00363
name: dTDP
type: Species
is: HMDB01274
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaR r2108
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_50571199_cdee_4ba2_b6c1_2fdbbf61c72c
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8WZ48
type: Species
name: CPT1A
is encoded by: hsa:1374
constant: false
initial concentration: NaN

metaM acetol c
type: Species
name: hydroxyacetone
is: CHEBI:27957
is: HMDB06961
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3

http://identifiers.org/biomodels.db/MODEL1310110029#_8cefde70_c175_446e_99ac_94fefa1de062
is: SBO:0000252
type: Species
is encoded by: hsa:64077
has only substance units: false
initial concentration: NaN
is: Q9H008
boundary condition: true
name: LHPP
initial amount: NaN
constant: false

metaM accoa m
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: HMDB01206
initial concentration: 1.0
constant: false
is: C00024
name: Acetyl-CoA
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57288
initial amount: NaN

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM dgtp e
type: Species
has only substance units: false
is: HMDB01440
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP

metaR CYTK12n
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110029#

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM acald e
name: acetaldehyde
is: SBO:0000247
has only substance units: false
is: CHEBI:15343
constant: false
type: Species
initial amount: NaN
is: HMDB00990
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
boundary condition: false

metaM dha e
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
is: CHEBI:16016
is: HMDB01882
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e340bd16_ef81_46e7_92f3_828acc1a99a3
is: P30043
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:645
has only substance units: false
name: BLVRB

metaM HC01434 m
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
is: CHEBI:58931
constant: false
name: oxalatosuccinate(3-)
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e9ce7b66_9d1d_4881_80f6_c91a8056df24
constant: false
boundary condition: true
name: DGKB
is encoded by: hsa:1607
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaR LEUKTRD4t
reactant: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110029#
name: leukotriene D4 transport
fast: false
type: Reaction
product: MODEL1310110029#

metaM fmn c
name: FMN
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: CHEBI:58210
constant: false
initial amount: NaN
is: HMDB01520
type: Species
initial concentration: 1.0
has only substance units: false
is: C00061
is: SBO:0000247

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM bilirub e
boundary condition: false
is: HMDB00054
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: CHEBI:57977
name: bilirubin(2-)

metaR CYSGLUexR
is: SBO:0000185
product: MODEL1310110029#
fast: false
name: L-cysteine/L-glutamine reversible exchanger
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000304

metaR RE0453N
reactant: MODEL1310110029#
is: SBO:0000176
name: RE0453
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ee4043eb_9eb6_4020_8901_f873275823be
is: SBO:0000252
boundary condition: true
is: A8K3L7
name: CDIPT
has only substance units: false
is encoded by: hsa:10423
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_13df85fc_5c56_4a53_89ed_bd3559f1a5d7
name: PKM2
constant: false
is encoded by: hsa:5315
initial amount: NaN
initial concentration: NaN
is: P14618
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR RE1448N
fast: false
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE1448
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaM 2obut c
name: 2-Oxobutanoate
initial concentration: 1.0
is: CHEBI:16763
constant: false
initial amount: NaN
type: Species
is: C00109
is: HMDB00005
boundary condition: false
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_2feec37c_ffd3_4361_be32_956e18dbf3fa
is: SBO:0000252
constant: false
is: Q4G1C4
type: Species
boundary condition: true
is encoded by: hsa:284273
name: ZADH2
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR ACOAD8m
kinetic law: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000176
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM glutcoa m
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01339
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378

metaR 34HPPOR
product: MODEL1310110029#
fast: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.27
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_adffc7ba_2c60_4d23_8adb_f7320e845faa
is encoded by: hsa:83549
boundary condition: true
name: UCK1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: Q5JT09
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_50493b74_1f23_480e_bf2a_8ab24578e827
boundary condition: true
type: Species
is: P04745
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AMY1C
constant: false
initial amount: NaN
is encoded by: hsa:278

metaM xylt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
type: Species
boundary condition: false
is: CHEBI:17151
is: SBO:0000247
name: xylitol
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR SUCOAS1m
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
product: MODEL1310110029#
is: SBO:0000176
name: Succinate--CoA ligase (GDP-forming)
reversible: true
fast: false

metaR r2105
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_5c8fd070_f4d3_4ab5_837b_d246886f857c
constant: false
name: _AI971036_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI971036
boundary condition: true
is: SBO:0000252
type: Species

metaM tag hs e
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
name: triglyceride
boundary condition: false
is: CHEBI:17855
initial amount: NaN
constant: false

metaM 13 cis retn c
type: Species
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
is: D00348
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial concentration: 1.0
constant: false
is: HMDB06219
boundary condition: false
initial amount: NaN
name: 13-cis-retinoate
is: SBO:0000247

metaM dtdp n
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:58369
type: Species
is: HMDB01274
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
initial concentration: 1.0

metaR 4HGLSDm
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110029#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_5d892b65_cb15_440c_82f3_7048493a4e06
has only substance units: false
constant: false
is encoded by: hsa:R06874
type: Species
is: SBO:0000252
initial concentration: NaN
name: _R06874_1_r
boundary condition: true
initial amount: NaN

metaM digalsgalside hs e
name: Digalactosylceramidesulfate
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
has only substance units: false
is: http://identifiers.org/pubchem.compound/8384
type: Species
boundary condition: false
is: C06127
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_671862d7_62c1_4263_a676_966c689d0926
is encoded by: hsa:9514
constant: false
name: GAL3ST1
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q99999
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_7569fefe_3815_460c_ab8c_7697fc86d6a4
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI653169
constant: false
name: _AI653169_1_c

metaR PCHOL HStg
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
name: phosphatidylcholine scramblase
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaR r2104
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
name: hexaglutamyl folate (THF)
constant: false

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaM glysar e
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/93131
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: Glycylsarcosine
notes: FORMULA: C5H10N2O3 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_5776fd8e_89a1_487e_a4b0_d9d4171402b7
boundary condition: true
constant: false
is: SBO:0000252
name: CDA
is: P32320
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:978
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_afe75273_e5c4_40ea_88ac_773f7f410bc6
is: O60488
is encoded by: hsa:2182
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACSL4
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7c91cd8f_9a05_4bd4_be8b_283536d02cda
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ALDH1B1
has only substance units: false
is: P30837
is encoded by: hsa:219

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
is: CHEBI:17151
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: xylitol
initial concentration: 1.0
is: HMDB02917

http://identifiers.org/biomodels.db/MODEL1310110029#_895de47e_248b_4185_875e_9f92b70bbcf2
name: NME2
boundary condition: true
type: Species
is encoded by: hsa:4831
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P22392
has only substance units: false
constant: false

metaM nadp c
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
is: CHEBI:58349
initial amount: NaN
is: SBO:0000247
constant: false
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
boundary condition: false
type: Species
is: C00006
is: HMDB00217

metaR r2107
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM alpam m
initial concentration: 1.0
is: SBO:0000247
name: S-aminomethyldihydrolipoamide
has only substance units: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
boundary condition: false
is: HMDB06239
type: Species
constant: false
initial amount: NaN

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_41151899_ba80_422c_9061_e4766eeda240
is: Q96CA6
name: ACAA1
constant: false
type: Species
is encoded by: hsa:30
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM 2maacoa m
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57335
is: HMDB01157
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
boundary condition: false
constant: false
has only substance units: false

metaM tag hs c
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
name: triglyceride
constant: false
is: CHEBI:17855

metaR NRPPHRt4 2 r
kinetic law: MODEL1310110029#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Norepinephrine reversible transport in via sodium symport (1:2)
type: Reaction
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_a20ebdb4_44fd_45b6_877b_4e638a4130a6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29922
is: Q9Y5B8
initial amount: NaN
name: NME7
type: Species
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_4f10ac24_d9f9_4d84_bf26_f24ff7fe5693
is: Q02318
initial concentration: NaN
name: CYP27A1
constant: false
has only substance units: false
is encoded by: hsa:1593
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_3ae562f5_1ccb_4a90_8d0b_9e6ac529335d
constant: false
has only substance units: false
is encoded by: hsa:2348
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: FOLR1
type: Species
is: SBO:0000252

metaM digalsgalside hs g
name: Digalactosylceramidesulfate
is: http://identifiers.org/pubchem.compound/8384
type: Species
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r1459
type: Reaction
fast: false
name: Transport reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_c04ca5a1_ee07_477a_8c27_0a443d9afbef
boundary condition: true
is encoded by: hsa:89869
constant: false
has only substance units: false
name: PLCZ1
initial amount: NaN
is: SBO:0000252
is: Q86YW0
type: Species
initial concentration: NaN

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r0560
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: false

metaR r2005
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction

metaR r2106
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#

metaR r0774
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110029#

metaR r0618
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

metaR ACACt2
reversible: true
product: MODEL1310110029#
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: acetoacetate transport via proton symport
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD

metaM frdp r
type: Species
name: Farnesyl diphosphate
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00448
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: CHEBI:175763
boundary condition: false

metaR PAIL45P HStn
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaM dtdp m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: HMDB01274
is: C00363
initial amount: NaN
constant: false
is: CHEBI:58369

metaM ps hs e
initial amount: NaN
is: CHEBI:18303
constant: false
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylserine
type: Species
boundary condition: false

metaR PROSTGI2tr
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
name: Prostaglandin I2 transport (ER)
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000269

MODEL1310110029#
stoichiometry: 0.279425
species: metaM HC02213 c
species: metaM HC01434 m
species: metaM HC02204 c
species: metaM crn e
species: metaM na1 e
species: metaM xol7aone r
species: metaM csn c
species: metaM succoa m
species: metaM 5fthf m
species: metaM nh4 n
species: metaM ppa c
species: metaM 4abut e
species: metaM hmgcoa m
species: metaM orot c
species: metaM 4aphdob c
species: metaM lys L e
species: metaM hLkynr c
species: metaM alpam m
species: metaM HC00591 m
species: metaM gthrd c
species: metaM dadp n
species: metaM ala L m
species: metaM o2s c
species: metaM dutp c
species: metaM xylu L c
species: metaM g6p c
species: metaM cgly c
species: metaM pap c
species: metaM HC00319 m
species: metaM HC01111 c
species: metaM abt e
species: metaM acac c
species: metaM 13dampp c
species: metaM gln L m
species: metaM HC01231 c
species: metaM HC02213 e
value: -100.0
species: metaM 2mcit e
species: metaM HC01522 c
has only substance units: false
species: metaM ac m
species: metaM dcacoa m
species: metaM bilglcur r
species: metaM ppi n
species: metaM ac e
species: metaM mal L c
species: metaM 2mop m
species: metaM ps hs c
species: metaM bilglcur c
species: metaM orn m
species: metaM nh4 e
species: metaM trdrd c
species: metaM orot e
species: metaM mercplaccys c
species: metaM his L e
species: metaM fol c
species: metaM prostge1 c
constant: false
species: metaM CE0693 m
species: metaM 2obut c
species: metaM ppi c
species: metaM nrpphr e
species: metaM glyc R c
stoichiometry: 3.0
species: metaM HC02121 c
species: metaM strdnc l
species: metaM urate e
species: metaM utp e
species: metaM nad c
stoichiometry: 1.5
species: metaM digalsgalside hs c
species: metaM ru5p D c
species: metaM h2o l
species: metaM pa hs m
species: metaM CE2421 m
species: metaM dpcoa l
species: metaM retinol 9 cis e
species: metaM CE1926 e
species: metaM arab L c

metaR r2101
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_753ccd16_adf9_4825_9902_47f2d3ae6c0b
boundary condition: true
name: ALDH3A2
constant: false
is: SBO:0000252
initial amount: NaN
is: P51648
is encoded by: hsa:224
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_9e7a6a45_85db_4ff5_b796_b37974025ac8
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:728226
initial concentration: NaN
name: _728226_1_e

metaR ARACHDt2
type: Reaction
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaM ile L e
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
is: HMDB00172
name: L-isoleucine
initial concentration: 1.0
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110029#_a560fb9b_3915_4240_93e6_5e01be4f06c2
constant: false
initial concentration: NaN
name: ALDH1A3
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: P47895
is encoded by: hsa:220

metaR ALAt2r
is: SBO:0000185
modifier: MODEL1310110029#
product: MODEL1310110029#
reversible: true
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110029#
type: Reaction
fast: false
reactant: MODEL1310110029#

metaR GLYCTDle
fast: false
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110029#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction

metaM CE2420 m
is: HMDB11123
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial concentration: 1.0
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false
constant: false
type: Species
is: CHEBI:28387
boundary condition: false

metaR r0437
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110029#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110029#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR r0082
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.2
product: MODEL1310110029#
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_9d077957_d0fc_44e1_827a_41a56e2e2344
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4048
initial concentration: NaN
constant: false
name: LTA4H
is: P09960

metaR Htx
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
name: H transporter, peroxisome
product: MODEL1310110029#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM udpgal e
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
constant: false
is: CHEBI:58439
name: UDP-D-galactose(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00302
type: Species
initial amount: NaN

metaR r2100
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaM dgtp n
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00286
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
has only substance units: false
is: HMDB01440
constant: false
is: CHEBI:16497

metaM dheas e
is: HMDB01032
type: Species
constant: false
has only substance units: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57905
is: SBO:0000247
initial amount: NaN

metaR 34DHXMANDACOX
reactant: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000269
reversible: false
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
kinetic law: MODEL1310110029#
is: SBO:0000176

metaR NTD4
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
reactant: MODEL1310110029#
name: 5'-nucleotidase (CMP)
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000254
modifier: MODEL1310110029#

metaM succ c
is: SBO:0000247
is: HMDB00254
name: Succinate
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:30031
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6d589f64_066d_4c3b_90c3_cbc6f67382cb
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: CHKA
is encoded by: hsa:1119
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_676625c8_a2c3_4d25_8e27_81b06cf6ae75
is: P52789
is encoded by: hsa:3099
boundary condition: true
name: HK2
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR AICART
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

metaR HMGCOASim
reversible: false
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
is: SBO:0000176
modifier: MODEL1310110029#

metaR r0081
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR r0616
reactant: MODEL1310110029#
is: SBO:0000176
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110029#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
fast: false

metaR r0779
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM ps hs c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
has only substance units: false
is: CHEBI:18303
name: ps_hs[c]
constant: false

metaR r2103
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110029#_bed8a8d6_b658_455d_a9fa_362f64054275
constant: false
name: PPAP2B
is encoded by: hsa:8613
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: O14495
boundary condition: true

metaR AHCYStd
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
fast: false
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine
kinetic law: MODEL1310110029#
is: SBO:0000185

metaR r2519
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
name: Utilized transport

metaR ALR2
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
name: aldose reductase (methylglyoxal)
fast: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
reversible: false
is described by: ECO:0000269

metaM e4hglu m
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
constant: false
is: CHEBI:6331
is: HMDB02273
initial concentration: 1.0
boundary condition: false
name: erythro-4-hydroxy-L-glutamate(1-)

metaM 3mb2coa m
boundary condition: false
is: HMDB01493
is: CHEBI:57344
name: 3-methylbut-2-enoyl-CoA(4-)
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2ef44ee9_bd96_47f5_89d2_9d366bd78605
has only substance units: false
name: TXNRD1
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:7296
boundary condition: true
type: Species

metaM malcoa c
has only substance units: false
name: Malonyl-CoA
is: C00083
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
type: Species
initial amount: NaN
is: CHEBI:57384

http://identifiers.org/biomodels.db/MODEL1310110029#_53b85770_093d_4785_8709_2f5dd6609fdd
type: Species
constant: false
boundary condition: true
has only substance units: false
is: Q9BXI2
name: SLC25A2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83884

metaR r0839
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.70
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_bbe99084_a2f8_4c11_861c_2ce87feb2856
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57127
is: SBO:0000252
constant: false
name: RHBG
is: Q9H310
boundary condition: true

metaM acald m
is: CHEBI:15343
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
name: acetaldehyde

metaR RE1691M
modifier: MODEL1310110029#
product: MODEL1310110029#
name: RE1691
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.1.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_a08cfe79_9f57_444b_a15d_c7c3f7461339
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: O75521
name: ECI2
is encoded by: hsa:10455
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaR DHCRD1
reactant: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
product: MODEL1310110029#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110029#
name: dihydroceramide desaturase
modifier: MODEL1310110029#

metaM 3hmp m
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
initial concentration: 1.0
is: HMDB00023
initial amount: NaN
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
constant: false
is: CHEBI:11805

http://identifiers.org/biomodels.db/MODEL1310110029#_245dc7eb_ff9c_4e55_b258_e815c3501aaf
is: SBO:0000252
is: P60891
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5631
type: Species
name: PRPS1
has only substance units: false

metaR HSD17B3r
fast: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: testicular 17-beta-hydroxysteroid dehydrogenase
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.64
reactant: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (3293.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12429500 NOTES:Human kidney cell line used and Km/Vmax quantified
is: SBO:0000176
type: Reaction
is described by: ECO:0000134

metaM udpgal g
is: HMDB00302
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58439
initial concentration: 1.0

metaR r0614
kinetic law: MODEL1310110029#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
reversible: true

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_97c69dbe_3d6d_4c85_99e4_87af6b85c2a8
constant: false
is encoded by: hsa:6555
boundary condition: true
has only substance units: false
name: SLC10A2
is: Q12908
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r2102
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_7f911677_6c05_4d8d_9709_143472a7b9a5
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: PANK4
is encoded by: hsa:55229
has only substance units: false
is: Q9NVE7

http://identifiers.org/biomodels.db/MODEL1310110029#_a74243d7_c4d4_4869_8e1d_71a17c061db4
type: Species
is: SBO:0000252
constant: false
name: TST
initial amount: NaN
boundary condition: true
is: Q16762
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7263

http://identifiers.org/biomodels.db/MODEL1310110029#_07dd3aaf_0331_41e7_a015_bad16f83e990
boundary condition: true
initial concentration: NaN
name: ACSL3
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2181
is: B3KMA6
type: Species
has only substance units: false

metaM digalsgalside hs c
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/8384
constant: false
has only substance units: false
name: Digalactosylceramidesulfate
boundary condition: false
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127

http://identifiers.org/biomodels.db/MODEL1310110029#_a8339b8b_17b4_4f33_90db_512d3daa0941
is: SBO:0000252
is encoded by: hsa:771
type: Species
boundary condition: true
constant: false
is: O43570
has only substance units: false
initial amount: NaN
name: CA12
initial concentration: NaN

metaR ALR3
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110029#
name: aldose reductase (acetol)
is: SBO:0000176
fast: false

metaM HC00718 c
boundary condition: false
constant: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
name: N-methylethanolaminium phosphate(1-)
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57781
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_0f8d18fe_ed47_41ad_a071_ca927f08f030
boundary condition: true
initial concentration: NaN
name: SLC24A4
type: Species
is encoded by: hsa:123041
is: SBO:0000252
constant: false
is: Q8NFF2
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_79ed3d94_d213_4987_aaa0_5abdda649581
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P49619
name: DGKG
constant: false
is encoded by: hsa:1608
type: Species
has only substance units: false

metaM succ e
is: HMDB00254
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: succinate(2-)
is: CHEBI:30031
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_308a5fe8_de25_414a_a5cc_6952491787d9
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: VNN3
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:55350

metaR r0838
reversible: true
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
name: Free diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110029#

metaM pro L c
name: L-proline
initial amount: NaN
is: SBO:0000247
is: CHEBI:17203
boundary condition: false
has only substance units: false
is: HMDB00162
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

http://identifiers.org/biomodels.db/MODEL1310110029#_5af9e75c_0c2b_4759_95f5_aa672a3ff606
has part: P15954
initial amount: NaN
is encoded by: hsa:4514
is encoded by: hsa:1339
is encoded by: hsa:1327
is encoded by: hsa:1346
is encoded by: hsa:1337
has part: Q53YB7
is encoded by: hsa:341947
has part: P20674
has only substance units: false
has part: Q7Z4L0
is encoded by: hsa:1349
has part: P00414
is encoded by: hsa:4512
is encoded by: hsa:4513
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:125965
is encoded by: hsa:1340
has part: Q7GXY8
boundary condition: true
has part: Q6YFQ2
is encoded by: hsa:1345
is encoded by: hsa:84701
has part: Q96KJ9
type: Species
has part: Q8TF08
has part: P24310
is encoded by: hsa:1347
has part: Q6FGA0
has part: P12074
constant: false
has part: P09669
has part: P24311
has part: Q02221
initial concentration: NaN
is encoded by: hsa:1351
has part: H0UI06
is encoded by: hsa:170712
is encoded by: hsa:9377
has part: P13073
has part: P14854
has part: Q53XN1
has part: Q7GXZ8
is: SBO:0000297
is encoded by: hsa:1329
is encoded by: hsa:9167
is encoded by: hsa:1350

metaR CYTD
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
name: cytidine deaminase
is: SBO:0000176
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
product: MODEL1310110029#
is described by: ECO:0000254
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_af66054f_0d53_4a51_9119_3d54dd6483b5
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:29925
initial concentration: NaN
has only substance units: false
name: GMPPB
is: SBO:0000252
is: Q9Y5P6

metaM thcholstoic c
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: HMDB03873
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:18402
constant: false
boundary condition: false
has only substance units: false

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
modifier: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r2322
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110029#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_c0174f92_e436_423a_a576_8eedfa104bad
is: Q14642
name: INPP5A
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3632
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_9cd855c2_3076_41d9_8022_e27ebd9f6e46
is: A8K596
is: SBO:0000252
is encoded by: hsa:1757
initial amount: NaN
type: Species
name: SARDH
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR NCKt
product: MODEL1310110029#
type: Reaction
fast: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange

metaR r0983
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110029#
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reactant: MODEL1310110029#
fast: false
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR r0558
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
modifier: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000

metaR FATP2t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
name: fatty acid electroneutral transport
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_82476dc7_1d07_4316_890d_5f3ae34993c4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AL525798
type: Species
has only substance units: false
constant: false
name: _AL525798_1_c
initial amount: NaN

metaM amp c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00045
constant: false
is: CHEBI:3322
boundary condition: false
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP

metaR TTDCAtr
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: tetradecanoate (transport)
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_15b2537c_b320_46af_b869_adbb2722bce8
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: TXNRD1
is: SBO:0000252
is encoded by: hsa:7296
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_049fea65_ec0d_4e73_8c5d_61736ac6b49a
is encoded by: hsa:1376
boundary condition: true
is: P23786
name: CPT2
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR r2525
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reversible: true

metaR CDSm
reversible: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000176
name: phosphatidate cytidylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_9560f5f7_6567_456d_847c_0a36caf4d96e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:763
name: CA5A
has only substance units: false
initial concentration: NaN
is: P35218
boundary condition: true
type: Species
constant: false

metaR r2323
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR LDH L
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reversible: true
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#

metaM nadp m
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00217
initial amount: NaN
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
boundary condition: false
is: C00006

metaR r0559
type: Reaction
fast: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaR RE2541E
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: RE2541
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C04677
type: Species
has only substance units: false
is: CHEBI:58475
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01517
is: SBO:0000247

metaM pro L e
initial amount: NaN
is: SBO:0000247
name: L-proline
is: CHEBI:17203
constant: false
is: HMDB00162
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR r2526
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false

metaM cpppg3 c
type: Species
has only substance units: false
is: CHEBI:57309
is: C03263
initial amount: NaN
boundary condition: false
is: HMDB01261
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
is: SBO:0000247
initial concentration: 1.0
name: Coproporphyrinogen III
constant: false

metaM 5mthf e
name: 5-Methyltetrahydrofolate
has only substance units: false
is: HMDB01396
boundary condition: false
is: C00440
type: Species
is: CHEBI:3729
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247

metaR r0186
reversible: false
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
fast: false

metaM udpgal c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00302
has only substance units: false
name: UDP-D-galactose(2-)
type: Species
is: CHEBI:58439
constant: false
boundary condition: false

metaM 5adtststerone c
has only substance units: false
initial amount: NaN
is: CHEBI:16330
is: SBO:0000247
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
is: HMDB02961

metaR r0556
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000176
fast: false

metaR G6Pter
modifier: MODEL1310110029#
fast: false
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5411171e_31aa_478d_9be8_80277ab7837d
is: Q9BWD1
is: SBO:0000252
name: ACAT2
has only substance units: false
is encoded by: hsa:39
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM 13 cis retn n
is: D00348
is: http://identifiers.org/pubchem.compound/7847414
type: Species
name: 13-cis-retinoate
is: HMDB06219
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaR r2324
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110029#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true

metaR r0835
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
product: MODEL1310110029#

metaM CE4872 c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial amount: NaN
constant: false
has only substance units: false

metaR GCC2bim
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110029#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
is: SBO:0000176

metaR LPS3
is: SBO:0000176
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.23
modifier: MODEL1310110029#
type: Reaction
name: lipase

http://identifiers.org/biomodels.db/MODEL1310110029#_d658cd00_e658_4c62_87d3_a6214743e103
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:F23536
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: _F23536_1_m

http://identifiers.org/biomodels.db/MODEL1310110029#_91fd3102_beb8_4402_a61e_d1d1d0b0c399
is: Q16739
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7357
boundary condition: true
name: UGCG

http://identifiers.org/biomodels.db/MODEL1310110029#_18e0c3fa_aa50_4329_8da9_25fdb59cc4b1
is encoded by: hsa:3628
is: P49441
initial concentration: NaN
initial amount: NaN
type: Species
name: INPP1
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_37d4b0c2_03ea_4625_8b54_4c3a72899913
is: Q674R7
name: ATG9B
initial amount: NaN
type: Species
is encoded by: hsa:285973
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_7bcee2ee_0549_42a5_8437_4b636af6c7c8
is: SBO:0000252
is encoded by: hsa:377841
is: Q5MY95
boundary condition: true
constant: false
type: Species
name: ENTPD8
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r1570
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
reversible: true
type: Reaction
fast: false

metaR RE1709C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
name: RE1709
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7b0f4dc8_7345_4721_aee8_bfaea780f951
boundary condition: true
is: SBO:0000252
name: NDUFB7
initial concentration: NaN
is encoded by: hsa:4713
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: P17568

metaM retn c
boundary condition: false
name: all-trans-retinoate
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01852
is: CHEBI:35291
type: Species
has only substance units: false

metaR r0557
fast: false
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
is: SBO:0000176
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false

metaM aicar e
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: C04677
has only substance units: false
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: HMDB01517

metaR r2325
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110029#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110029#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_e14575f0_0d3e_4d70_a302_8f58d7ebe445
name: SLC22A2
constant: false
is: SBO:0000252
is encoded by: hsa:6582
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: O15244

metaM ocdca c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827
initial concentration: 1.0
name: stearate
constant: false
type: Species
is: CHEBI:25629

http://identifiers.org/biomodels.db/MODEL1310110029#_4ba871f0_007f_41c9_99a7_7c680e415a11
initial amount: NaN
name: GBA
constant: false
initial concentration: NaN
is encoded by: hsa:2629
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: B7Z6S9

metaR r2520
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false

metaR r0834
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
product: MODEL1310110029#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
type: Reaction

metaR NADtx
reactant: MODEL1310110029#
name: transport of NAD into peroxisome
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134

metaR r0784
product: MODEL1310110029#
is described by: ECO:0000000
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR r2439
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110029#

metaR r1573
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaR UDPG4E
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
type: Reaction
reversible: true
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000134
modifier: MODEL1310110029#
name: UDPglucose 4-epimerase
fast: false

metaM val L c
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
name: L-valine
is: SBO:0000247
is: CHEBI:16414
initial amount: NaN
has only substance units: false
is: HMDB00883
boundary condition: false
type: Species

metaM 5mthf c
name: 5-Methyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
is: HMDB01396
initial amount: NaN
is: C00440
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0493504d_57d4_493d_a248_c76dd129c178
is encoded by: hsa:3158
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HMGCS2
type: Species
boundary condition: true
is: P54868
is: SBO:0000252

metaR r2521
kinetic law: MODEL1310110029#
fast: false
reversible: true
is: SBO:0000185
name: Utilized transport
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:

metaR DNDPt29m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
is: SBO:0000185
modifier: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
name: dCDP transport via dADP antiport

metaR FTHFL
name: Formate-tetrahydrofolate ligase
type: Reaction
product: MODEL1310110029#
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.5

metaM nadp r
is: HMDB00217
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: C00006
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
is: CHEBI:58349

metaR LPS4e
reactant: MODEL1310110029#
name: phospholipase
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is: SBO:0000176
reversible: false

metaR r1930
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_ed29cb85_9c5a_4f7f_9b67_48c88c0a78ea
initial amount: NaN
name: SLC22A1
is: SBO:0000252
type: Species
boundary condition: true
is: O15245
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6580

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR r0181
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM succ m
initial amount: NaN
is: SBO:0000247
is: HMDB00254
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:30031
name: Succinate
is: C00042
type: Species

metaR D3AIBTm
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false
reactant: MODEL1310110029#
type: Reaction
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM trp L c
name: L-tryptophan
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16828
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7a0f9cae_783b_4bc6_8c57_0f0362cf6356
is: SBO:0000297
name: SLC7A10:SLC3A2
constant: false
is encoded by: hsa:6520
has part: Q9NS82
initial amount: NaN
is encoded by: hsa:56301
has part: P08195
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR THRGLYexR
is described by: ECO:0000304
reactant: MODEL1310110029#
type: Reaction
name: L-threonine/glycine reversible exchange
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
reversible: true
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5a239c90_3781_4459_a694_a0c7f3b9bf90
boundary condition: true
is encoded by: hsa:170712
type: Species
name: COX7B2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q8TF08
constant: false

metaM glysar c
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Glycylsarcosine
constant: false
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/93131

http://identifiers.org/biomodels.db/MODEL1310110029#_150bc7f0_aaa8_4542_81bd_9486431a34f6
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728441
initial amount: NaN
name: GGT2
is: SBO:0000252
boundary condition: true
type: Species

metaR r1575
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 13 cis retn r
is: HMDB06219
is: D00348
name: 13-cis-retinoate
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
is: SBO:0000247
constant: false

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaM mal L m
name: (S)-malate(2-)
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00156
is: CHEBI:15589

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
product: MODEL1310110029#
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ba33cf93_985c_4728_a283_5cd16ed4bda5
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9H5J4
name: ELOVL6
constant: false
is encoded by: hsa:79071

metaM val L e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
initial amount: NaN
is: CHEBI:16414
has only substance units: false
is: HMDB00883
constant: false
boundary condition: false
type: Species

metaM retinal c
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:15035
is: SBO:0000247
initial amount: NaN
name: retinal
is: HMDB01358

metaR r2320
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR RE3347C
reactant: MODEL1310110029#
name: RE3347
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
reversible: true
type: Reaction

metaM fe2 m
name: Fe2+
initial amount: NaN
initial concentration: 1.0
is: C00023
type: Species
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
is: HMDB00692
is: CHEBI:29033
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_e3b70b5e_5581_4d60_af39_59a244dd914f
is encoded by: hsa:AI697028
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI697028_1_e
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_83749735_d11a_4f81_8a59_5a782a9e02e3
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4719
is: P28331
name: NDUFS1
is: SBO:0000252
constant: false
boundary condition: true

metaR RE1897C
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE1897
reversible: true
reactant: MODEL1310110029#

metaR RETFAt
product: MODEL1310110029#
reversible: false
is described by: ECO:0000000
name: fatty acid retinol efflux
is: SBO:0000185
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

metaM glcur e
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: HMDB00127
initial concentration: 1.0
has only substance units: false
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110029#_ea190399_4360_4d5f_b7e9_ae4efa6354c9
is encoded by: hsa:54963
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q53HM1
type: Species
initial amount: NaN
boundary condition: true
name: UCKL1

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5c0eb9cf_c9bc_4aaf_be10_e0f43dfa5c22
is: SBO:0000252
initial concentration: NaN
is: P16930
has only substance units: false
type: Species
boundary condition: true
name: FAH
is encoded by: hsa:2184
initial amount: NaN
constant: false

metaR ACACT10m
is described by: ECO:0000134
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110029#

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_53cbdb33_2882_4811_b202_becac9691a8b
constant: false
is encoded by: hsa:4698
type: Species
is: Q16718
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NDUFA5
initial concentration: NaN
has only substance units: false

metaR r0984
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reversible: true

metaR r0783
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_5776e4cc_cb2f_43a3_97ef_ff88f95b5cfe
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9Y217
name: MTMR6
type: Species
is encoded by: hsa:9107
boundary condition: true

metaR r2002
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110029#_d142faab_6a77_44b0_adab_eb96636ae284
type: Species
is encoded by: hsa:84532
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9NUB1
constant: false
is: SBO:0000252
has only substance units: false
name: ACSS1

metaR r2321
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR NDPK9n
is described by: ECO:0000269
modifier: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000185

metaM mlthf m
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
is: HMDB01533
is: C00143
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15636

metaM HC01223 m
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57340
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
type: Species

metaM citr L e
has only substance units: false
initial concentration: 1.0
is: CHEBI:16349
constant: false
is: HMDB00904
boundary condition: false
is: SBO:0000247
name: citr_L[e]
initial amount: NaN
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaR 4HOXPACDOX NADP
is: SBO:0000176
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110029#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR HSD3A2r
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
reversible: true
modifier: MODEL1310110029#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR r0226
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
modifier: MODEL1310110029#
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110029#

metaM 5adtststerones e
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
is: HMDB06278
type: Species
name: 5alpha-Dihydrotestosterone sulfate
initial concentration: 1.0

metaR RBFK
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.26
name: riboflavin kinase
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is: SBO:0000176

metaR DUTPDPn
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110029#
name: dUTP diphosphatase, nuclear

metaM ak2lgchol hs e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/6975
is: C04317
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
boundary condition: false
initial amount: NaN

metaR r0830
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_50035f7b_4c89_430e_af13_8fcf6e2f44ae
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9HAS3
is encoded by: hsa:64078
type: Species
initial amount: NaN
constant: false
name: SLC28A3
initial concentration: NaN

metaR DNDPt23m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: dTDP transport via dGTP antiport
product: MODEL1310110029#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269

metaM trp L e
is: CHEBI:16828
is: SBO:0000247
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00929
initial concentration: 1.0

metaM 9 cis retfa e
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: fatty acid 9-cis-retinol
initial amount: NaN
is: HMDB06559
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110029#_471c757f_0df9_4731_928b_222db3abd0e7
name: GPX1
has only substance units: false
boundary condition: true
is encoded by: hsa:2876
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a206739c_923f_4ecb_b681_87329c066768
initial concentration: NaN
name: ACP1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:52
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q59EH3

metaR NAIt
fast: false
reversible: true
is described by: ECO:0000269
name: Na+ / iodide cotransport
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5f27d279_72b9_4abf_9b22_dc96d92854de
initial concentration: NaN
is encoded by: hsa:7359
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: _7359_1_c
is: SBO:0000252

metaM s7p c
constant: false
is: C05382
initial amount: NaN
boundary condition: false
is: HMDB01068
has only substance units: false
initial concentration: 1.0
name: Sedoheptulose 7-phosphate
type: Species
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: SBO:0000247
is: CHEBI:57483

metaR r1576
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5092bb33_742c_4e49_9b6c_977ee217dd72
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:277
type: Species
is: P04745
constant: false
name: AMY1B
initial amount: NaN
is: SBO:0000252

metaR LDH D
fast: false
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reversible: true
name: D-lactate dehydrogenase
modifier: MODEL1310110029#
is described by: ECO:0000304
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176

metaR RE1709N
is: SBO:0000176
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a3eaef05_f10b_4bee_826a_ac8ccfae7306
type: Species
is: P54868
boundary condition: true
initial amount: NaN
is encoded by: hsa:3158
constant: false
has only substance units: false
is: SBO:0000252
name: HMGCS2
initial concentration: NaN

metaM dtmp e
boundary condition: false
type: Species
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
name: dTMP(2-)
is: CHEBI:26999
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d1f54f75_13f7_4f2a_b91b_c72b61f90cb6
is encoded by: hsa:27068
is: F8WDN9
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PPA2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c1222cd5_77e2_4874_a201_644c16f91808
type: Species
is encoded by: hsa:1633
initial concentration: NaN
name: DCK
constant: false
is: P27707
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r0330
kinetic law: MODEL1310110029#
reversible: false
type: Reaction
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaM citr L c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: L-citrulline
is: CHEBI:16349
boundary condition: false
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
type: Species
is: SBO:0000247

metaR r1684
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110029#
reversible: false
is: SBO:0000185
fast: false

metaM pro L m
is: HMDB00162
type: Species
name: L-proline
has only substance units: false
is: CHEBI:17203
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_a9d599b7_72fe_402a_b8e6_6b94dc441fe4
initial concentration: NaN
is: SBO:0000252
is: Q6PCB7
has only substance units: false
boundary condition: true
constant: false
name: SLC27A1
type: Species
is encoded by: hsa:376497
initial amount: NaN

metaM ahcys m
is: CHEBI:16680
initial concentration: 1.0
initial amount: NaN
is: C00021
has only substance units: false
boundary condition: false
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
is: SBO:0000247
constant: false
name: S-Adenosyl-L-homocysteine

metaM ak2lgchol hs c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/6975
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
boundary condition: false
is: C04317

metaM malttr e
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
is: C01835
is: CHEBI:27931
name: maltotriose
initial amount: NaN
type: Species
has only substance units: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM 5adtststerones c
is: HMDB06278
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM orn c
initial concentration: 1.0
constant: false
is: C01602
has only substance units: false
name: Ornithine
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
is: HMDB00214

metaR r1579
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_1dfdfc23_9fba_4883_aafe_e62f6443d56b
has only substance units: false
is encoded by: hsa:3157
constant: false
boundary condition: true
name: HMGCS1
is: SBO:0000252
initial amount: NaN
is: Q01581
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_37f2d4dc_914a_4398_84f2_c8741badf3bc
initial concentration: NaN
constant: false
name: _AI631997_1_m
is encoded by: hsa:AI631997
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_6d7fe243_5389_4e00_8b97_4c9340d9f0d1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_72228d97_ab3b_4df1_8c60_a4378a806d78
is: P31213
initial concentration: NaN
name: SRD5A2
type: Species
constant: false
is encoded by: hsa:6716
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_c1f68063_79b0_4339_bdd5_b0f141e9d686
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51251
constant: false
name: NT5C3
has only substance units: false
is: Q9H0P0
initial amount: NaN
boundary condition: true

metaR CSm
reversible: false
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
reactant: MODEL1310110029#
type: Reaction
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
name: citrate synthase
product: MODEL1310110029#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.3.1
modifier: MODEL1310110029#

metaM frdp c
initial concentration: 1.0
type: Species
name: Farnesyl diphosphate
is: CHEBI:175763
is: C00448
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00961
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247

metaR r1578
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR RE1517M
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
name: RE1517
fast: false
kinetic law: MODEL1310110029#

metaR CYSGLYexR
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
name: L-cysteine/glycine reversible exchanger
reversible: true
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:27647
name: prostaglandin-g2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d53ff831_a8c9_46ac_b132_78a5d4004532
name: NDUFB6
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4712
is: SBO:0000252
is: O95139

http://identifiers.org/biomodels.db/MODEL1310110029#_8b4774b1_d955_4a69_bcca_35bb533ffc7f
constant: false
is: E7ET30
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AK3
initial amount: NaN
type: Species
is encoded by: hsa:50808
boundary condition: true

metaM ru5p D c
is: CHEBI:58121
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
is: SBO:0000247
is: HMDB00618
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM csn c
is: SBO:0000247
type: Species
name: cytosine
initial amount: NaN
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
is: HMDB00630
has only substance units: false
is: CHEBI:16040
boundary condition: false

metaR CSND
kinetic law: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
name: Cytosine deaminase

http://identifiers.org/biomodels.db/MODEL1310110029#_0209b522_7ef9_4c2a_9696_4980a7f9e178
is: Q99798
boundary condition: true
is encoded by: hsa:50
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ACO2

metaR r2326
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d75c44b3_b0c0_4a33_bb46_c8c90acfa2f5
constant: false
is encoded by: hsa:956
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O75355
name: ENTPD3
is: SBO:0000252

metaR Htg
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: proton diffusion (Golgi)
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaM mi14p c
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
initial concentration: 1.0
is: CHEBI:58282
is: HMDB00968
has only substance units: false

metaM lpam m
is: HMDB00962
name: lipoamide
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17460
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b7cf80ba_b152_4ca9_bcb1_27d577a6c624
initial concentration: NaN
has only substance units: false
name: HADH
constant: false
is: SBO:0000252
is encoded by: hsa:3033
initial amount: NaN
type: Species
is: Q16836
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_53cc430a_3d9c_4ff7_a154_4b5a146e8dc4
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _U52111_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:U52111

http://identifiers.org/biomodels.db/MODEL1310110029#_208d64c4_753a_45f7_ba90_6c3a120895b6
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR UMPK4n
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR ADK3m
is described by: ECO:0000269
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110029#
name: adentylate kinase (GTP)
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#

metaR PAFS
is: SBO:0000176
kinetic law: MODEL1310110029#
reversible: false
name: alkyl glycerol phosphocholine acetyl transferase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR LNLCCPT2
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110029#
type: Reaction

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110029#
is described by: ECO:0000134
modifier: MODEL1310110029#
name: NADH dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ad08afe7_c303_421d_9eca_517c5de5191c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:124583
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: CANT1
type: Species
is: Q8WVQ1

metaR q10tm
is: SBO:0000185
kinetic law: MODEL1310110029#
reversible: true
fast: false
name: transport of ubiquinone into mitochondria
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110029#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110029#_caa92ae1_59ae_40cd_8c5d_fd292833ebee
name: TKT
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:7086
is: E7EPA7
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM triodthy e
is: CHEBI:18258
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
has only substance units: false
is: SBO:0000247

metaM mmcoa R m
has only substance units: false
is: HMDB01269
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial amount: NaN
type: Species
is: CHEBI:57326
constant: false
initial concentration: 1.0
boundary condition: false

metaM accoa c
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
has only substance units: false
name: Acetyl-CoA
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01206
boundary condition: false
is: CHEBI:57288
is: C00024
type: Species

metaM leuktrD4 e
is: CHEBI:28666
type: Species
is: HMDB03080
name: Leukotriene D4
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN

metaM prostgd2 r
is: SBO:0000247
boundary condition: false
name: prostaglandin D2(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57406
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false

metaR r2327
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110029#

metaM dnad c
boundary condition: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
initial amount: NaN
is: HMDB01179
is: CHEBI:18304
initial concentration: 1.0
has only substance units: false
is: C00857
is: SBO:0000247
type: Species
constant: false

metaR PAFt
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR PROSTGE1t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110029#
fast: false
type: Reaction
reversible: true
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_e9a5ee04_48bc_45d0_a04b_19529b657779
is encoded by: hsa:6536
initial amount: NaN
name: SLC6A9
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: P48067

metaM retinal cis 13 r
is: CHEBI:45487
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
type: Species
is: HMDB06220
name: 13-cis-retinal
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_2ee0d964_4d07_4feb_b326_2328ea3a3717
is: SBO:0000252
constant: false
is: Q5SYN6
initial concentration: NaN
name: SLC22A3
type: Species
is encoded by: hsa:6581
boundary condition: true
has only substance units: false
initial amount: NaN

metaM 13dpg c
is: C00236
is: HMDB01270
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3535
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 3-Phospho-D-glyceroyl phosphate
is: CHEBI:57604
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaM HC01434 c
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:58931
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
constant: false

metaR LNLCCPT1
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
reversible: false
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR GLNtN1
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110029#
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269

metaM csn e
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: cytosine
constant: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
is: CHEBI:16040
has only substance units: false
initial concentration: 1.0
type: Species

metaM acnam n
boundary condition: false
initial amount: NaN
is: CHEBI:35418
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00230
has only substance units: false
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM mi4p D c
initial concentration: 1.0
type: Species
name: 1D-myo-inositol 4-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
initial amount: NaN
is: CHEBI:58469
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01313
boundary condition: false

metaM orn e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
is: HMDB00214
type: Species
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
initial amount: NaN
constant: false
is: C01602

http://identifiers.org/biomodels.db/MODEL1310110029#_ab67e5d0_a794_479c_9ac1_38cd3ec290dc
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10400
name: PEMT
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR r2328
kinetic law: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000

metaM val L m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00883
type: Species
is: CHEBI:16414
constant: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_895d855b_4ad4_4cc6_b721_1d2117efa08c
has only substance units: false
is: Q9UBM1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: PEMT
boundary condition: true
is encoded by: hsa:10400
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_9d6e4b09_5610_4358_a349_0a163a7ee73a
is encoded by: hsa:26289
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: AK5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_62de598e_0224_4a80_92f9_74a2ef646d2e
initial concentration: NaN
is: O95168
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4710
initial amount: NaN
has only substance units: false
constant: false
name: NDUFB4
type: Species

metaR r0295
reactant: MODEL1310110029#
is: SBO:0000176
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110029#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaM fprica c
is: SBO:0000247
initial concentration: 1.0
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: C04734
initial amount: NaN
is: HMDB01439
constant: false
type: Species
is: CHEBI:58467
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
boundary condition: false
has only substance units: false

metaM triodthy c
is: HMDB00265
is: CHEBI:18258
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR DNDPt18m
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110029#
name: dUDP transport via ADP antiport
is described by: ECO:0000269
reactant: MODEL1310110029#
reversible: false

metaR TCYNTtm
name: Thiocyanate transport via diffusion (mitochondrial)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR r1937
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false

metaR r2329
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true

metaM leuktrD4 c
initial amount: NaN
is: CHEBI:28666
has only substance units: false
name: Leukotriene D4
type: Species
is: HMDB03080
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaR DOPAt4 2 r
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#

metaR DM anth
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR RE1527M
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
name: RE1527
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR RE2799C
name: RE2799
reversible: true
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110029#

metaM 13dampp c
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:57484
is: HMDB00002
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
name: trimethylenediaminium
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_fde27963_7e24_4b2d_a5f4_0a37ae5d4470
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ACOX3
is: O15254
is encoded by: hsa:8310
constant: false
initial amount: NaN

metaM nadp x
is: SBO:0000247
initial amount: NaN
is: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
initial concentration: 1.0
is: CHEBI:58349
is: HMDB00217

metaR DM 13 cis retn n
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaM dolglcp L c
is: SBO:0000247
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial concentration: 1.0
constant: false
is: CHEBI:15812

http://identifiers.org/biomodels.db/MODEL1310110029#_7baf0fb5_d31b_46a8_8bac_2e1810980df8
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: P36269
is encoded by: hsa:2687
name: GGT5
initial concentration: NaN
boundary condition: true

metaM nad m
constant: false
boundary condition: false
initial concentration: 1.0
is: C00003
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
initial amount: NaN
is: HMDB00902
has only substance units: false
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110029#_3646088d_9e62_4b88_94ec_6f2e113eea0b
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: _U37519_1_e
type: Species
initial concentration: NaN
is encoded by: hsa:U37519
is: SBO:0000252

metaR PI45P5Pn
reversible: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
type: Reaction
reactant: MODEL1310110029#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
is: SBO:0000176
is described by: ECO:0000000

metaR r1464
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
reversible: true
name: Active transport
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_348942e9_17f6_45e4_88f1_2d066d81d97d
constant: false
boundary condition: true
type: Species
name: RRM2
is encoded by: hsa:6241
is: P31350
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_9f6bdac1_b67a_4fac_881d_338567840c4d
is: O94788
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ALDH1A2
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8854

http://identifiers.org/biomodels.db/MODEL1310110029#_298b8c1c_d543_4a64_b9c8_6603cb8d7eeb
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:3948
name: LDHC
has only substance units: false
is: P07864
boundary condition: true

metaR LCADi D
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
kinetic law: MODEL1310110029#
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000304
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110029#

metaM amp r
is: HMDB00045
initial concentration: 1.0
initial amount: NaN
name: AMP
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: C00020
constant: false
is: CHEBI:456215
boundary condition: false

metaM CE2417 m
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: CHEBI:28387
is: HMDB11123
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_eb0fbed0_be44_4216_b151_907adc116b55
boundary condition: true
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55350
has part: O95498
type: Species
constant: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM oaa m
is: HMDB00223
initial concentration: 1.0
initial amount: NaN
name: Oxaloacetate
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
boundary condition: false
is: C00036
is: SBO:0000247
has only substance units: false
is: CHEBI:16452
constant: false

metaM HC01415 m
type: Species
initial concentration: 1.0
boundary condition: false
name: (2E)-Octenoyl-CoA
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:27537
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: SBO:0000247

metaR AMPtp
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
reactant: MODEL1310110029#
name: AMP transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000269

metaM gua e
initial amount: NaN
is: SBO:0000247
is: CHEBI:16235
constant: false
has only substance units: false
type: Species
name: guanine
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
initial concentration: 1.0
is: HMDB00132

metaR PHYCBOXL
is: SBO:0000176
reversible: false
name: L-Phenylalanine carboxy-lyase
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000212
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
fast: false

metaM C02528 r
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
type: Species
is: CHEBI:36234
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: chenodeoxycholate
is: HMDB00518

http://identifiers.org/biomodels.db/MODEL1310110029#_e88c40dd_0144_4189_8d36_f86812607f5a
is: SBO:0000252
type: Species
is encoded by: hsa:2879
initial concentration: NaN
boundary condition: true
name: GPX4
initial amount: NaN
has only substance units: false
is: P36969
constant: false

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_70160689_718e_43ea_9647_922530a98497
name: ACP2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:53
is: E9PCI1

metaR LEUKTRB4t
fast: false
name: leukotriene B4 transport
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM imp e
is: SBO:0000247
is: HMDB00175
name: IMP(2-)
has only substance units: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58053
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_25739737_a96a_4282_8a18_ec2ff975928e
is: O14521
boundary condition: true
name: SDHD
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110029#_6c0e6388_1d89_4b17_8f0b_55b6cedc72d9
initial concentration: NaN
is: B2ZGL7
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:11343
has only substance units: false
initial amount: NaN
name: MGLL
type: Species

metaM prostgh2 e
has only substance units: false
name: prostaglandin H2(1-)
is: HMDB01381
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
constant: false
boundary condition: false
type: Species
initial amount: NaN

metaM pheacgln e
is: HMDB06344
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58310
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM thp2c c
initial amount: NaN
name: 1-piperideine-6-carboxylate
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB12130
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false
type: Species

metaM 5adtststerone r
has only substance units: false
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR RE3218C
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
reactant: MODEL1310110029#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
name: RE3218
fast: false
product: MODEL1310110029#
is described by: ECO:0000000

metaR TSULt4 3
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reversible: true
fast: false
type: Reaction
product: MODEL1310110029#
name: thiosulfate transport via sodium symport
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR r0317
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000000
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110029#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110029#_c1dae8de_5f95_40da_9512_563a59ce1464
is: SBO:0000252
is encoded by: hsa:23517
boundary condition: true
initial amount: NaN
type: Species
is: Q3MHC9
has only substance units: false
constant: false
name: SKIV2L2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_146ea016_a479_42a1_a71a_4ba0cdaf3890
constant: false
name: NME1
type: Species
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR LTA4H
product: MODEL1310110029#
is described by: ECO:0000134
modifier: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110029#
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
fast: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6d546eab_a619_4a67_88ef_264c7a5b2b05
has only substance units: false
boundary condition: true
name: SLC25A15
initial amount: NaN
initial concentration: NaN
is: Q9Y619
is encoded by: hsa:10166
is: SBO:0000252
type: Species
constant: false

metaR 3HCO3 NAt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110029#
name: 3HCO3_NAt
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110029#

metaM ahcys c
initial concentration: 1.0
is: HMDB00939
type: Species
initial amount: NaN
is: CHEBI:16680
is: C00021
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
is: SBO:0000247

metaM lald D c
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17167
name: (R)-lactaldehyde

http://identifiers.org/biomodels.db/MODEL1310110029#_532442f5_ce90_4a57_bb5c_e70ec4432f34
is encoded by: hsa:55293
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: UEVLD
initial amount: NaN
is: Q8IX04
type: Species

metaM fe2 c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00692
is: C00023
has only substance units: false
type: Species
is: CHEBI:29033
name: Fe2+
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN

metaR HIStN1
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110029#
type: Reaction
fast: false
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_55cd93c1_a857_4ce1_8e7f_fa8fe02f0aac
has only substance units: false
is: O60331
constant: false
is: SBO:0000252
name: PIP5K1C
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23396
boundary condition: true

metaM acnam c
is: CHEBI:35418
initial amount: NaN
boundary condition: false
is: HMDB00230
name: N-acetylneuraminate
initial concentration: 1.0
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
has only substance units: false
type: Species

metaM Lkynr c
is: CHEBI:16946
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial concentration: 1.0
is: HMDB00684
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: L-kynurenine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_4137ce53_22ba_4028_b27e_6adfb6abc2cb
is: B4DG68
initial amount: NaN
name: NOS1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4842

metaR r0074
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_a4ffdfa7_8c0b_4b93_a4bc_1ec132c7c45f
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: _AL050025_1_c
is encoded by: hsa:AL050025
has only substance units: false
initial concentration: NaN

metaR THRD L
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
name: L-threonine deaminase
reversible: false
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.3.1.17
product: MODEL1310110029#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_8cc92e1b_7392_4c02_8eb1_8eab594246b7
type: Species
boundary condition: true
is encoded by: hsa:BE042354
initial concentration: NaN
name: _BE042354_1_m
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_84b75239_9849_4465_87ac_7c1c6836f8f1
constant: false
initial amount: NaN
is encoded by: hsa:6241
initial concentration: NaN
name: RRM2
type: Species
boundary condition: true
is: P31350
has only substance units: false
is: SBO:0000252

metaM 5aop c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
constant: false
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
is: HMDB01149
type: Species
has only substance units: false
boundary condition: false

metaM gua c
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
name: Guanine
initial concentration: 1.0
is: C00242
has only substance units: false
is: SBO:0000247
is: CHEBI:16235
constant: false
is: HMDB00132
type: Species
boundary condition: false

metaR r0009
kinetic law: MODEL1310110029#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_1cea37b6_5cf2_41d0_bf19_3721d1e76842
boundary condition: true
is: SBO:0000252
is: B4DUY1
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: STARD3
is encoded by: hsa:10948

http://identifiers.org/biomodels.db/MODEL1310110029#_f2bf37d3_b24b_4569_9ac4_a337e8e0c4ae
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:11343
name: MGLL
type: Species
is: Q99685

metaR MI13PP
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
fast: false
product: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000176
name: inositol-1,3-bisphosphate 3-phosphatase

metaM pheacgln c
is: HMDB06344
is: SBO:0000247
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
initial amount: NaN
initial concentration: 1.0
type: Species

metaR CHATn
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110029#
name: Choline O-acetyltransferase
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR ADPtx
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
reversible: true
name: ADP transporter, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110029#_a2d56ad2_fdb2_4fcb_983a_8fb0916210d1
boundary condition: true
initial amount: NaN
is: A8K761
name: NDUFB10
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4716
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4da49851_2e57_400d_a995_0659d43ffaa8
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2629
is: P04062
type: Species
initial amount: NaN
initial concentration: NaN
name: GBA

metaM prostgh2 c
initial amount: NaN
is: CHEBI:57405
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01381
initial concentration: 1.0
name: prostaglandin H2(1-)
constant: false

metaM cit c
is: C00158
boundary condition: false
type: Species
has only substance units: false
is: HMDB00094
name: Citrate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9452437f_e619_4bdf_8ed6_78504b61fae1
initial concentration: NaN
has only substance units: false
name: AMY2A
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P04746
constant: false
is encoded by: hsa:279
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_0a082866_3371_450f_9aa3_03ce5878caa0
is: SBO:0000252
initial concentration: NaN
name: NT5C2
type: Species
is encoded by: hsa:22978
is: P49902
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_686c5ad6_1023_49b5_acea_461b6f27315e
type: Species
is: SBO:0000252
initial amount: NaN
name: _J03866_1_m
has only substance units: false
is encoded by: hsa:J03866
constant: false
boundary condition: true
initial concentration: NaN

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_f0cf62e4_a409_49aa_b125_67805af4184a
is encoded by: hsa:4702
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFA8
is: B1AM93
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_cef139f0_90f6_47e6_b1f4_abf4d8d22c28
name: PKLR
is encoded by: hsa:5313
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P30613
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e6f43c5c_4f9d_4def_bf75_f45039fbdcb4
initial amount: NaN
is encoded by: hsa:AI971023
is: SBO:0000252
boundary condition: true
name: _AI971023_1_c
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_e0be3cb7_5d3c_49a9_8d81_aba520a3144e
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM gmp c
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01397
initial concentration: 1.0
is: C00144
initial amount: NaN
name: GMP
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR BHBt
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction

metaR r0208
modifier: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.4.1.1
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_0c6177b5_9a4d_4973_ac99_43bdc2e8073e
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1346
initial concentration: NaN
is: P24310
has only substance units: false
name: COX7A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_d4a2b513_7f64_4da7_9de2_3a94935c3f8a
initial concentration: NaN
is: P15328
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_64d05db6_9354_44b0_a97f_4b4983340239
name: RPE
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6120
is: SBO:0000252
type: Species
is: Q96AT9
boundary condition: true
constant: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR NACDe
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM amp m
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
initial amount: NaN
constant: false
is: CHEBI:456215
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: AMP(2-)

metaM o2 m
has only substance units: false
initial amount: NaN
is: C00007
is: CHEBI:15379
is: HMDB01377
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
constant: false
name: O2
initial concentration: 1.0

metaR CHOLATEt
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110029#
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ad436761_ffec_4f43_86b0_8d5983e43ef7
is: SBO:0000252
boundary condition: true
name: EHHADH
is: Q9NY65
has only substance units: false
is encoded by: hsa:1962
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaM retfa e
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false
is: HMDB00508
type: Species
is: CHEBI:15963
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: fatty acid retinol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_05b9f6ae_a795_40e1_9f5f_ac5822bcc840
has only substance units: false
is: O43678
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: NDUFA2
is encoded by: hsa:4695
initial concentration: NaN

metaR GLNtm
product: MODEL1310110029#
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
type: Reaction

metaM bhb e
is: HMDB00011
has only substance units: false
is: CHEBI:10983
is: SBO:0000247
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_0b9726e2_890d_4a01_90c1_28e1b2c15f43
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: _728226_1_m
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:728226

metaM e4p c
boundary condition: false
initial concentration: 1.0
is: HMDB01321
constant: false
has only substance units: false
is: SBO:0000247
name: D-Erythrose 4-phosphate
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species
is: C00279
is: CHEBI:16897

metaR ALDD2xm
kinetic law: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
product: MODEL1310110029#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
type: Reaction
reversible: false

metaM etha c
constant: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
initial concentration: 1.0
is: CHEBI:57603
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: etha[c]
is: HMDB00149

http://identifiers.org/biomodels.db/MODEL1310110029#_53e467a8_efa5_4cac_aece_48e339ff4ba4
initial amount: NaN
type: Species
is encoded by: hsa:7498
name: XDH
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P47989

http://identifiers.org/biomodels.db/MODEL1310110029#_80e23ae1_cbe7_418f_9bf0_cb42ae30c7af
is: SBO:0000252
type: Species
name: _T83654_1_e
constant: false
is encoded by: hsa:T83654
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR MDHm
is described by: ECO:0000134
name: malate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
modifier: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.37
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_d57a5c1d_e2a3_4fd4_a8a8_3cedca17ed9c
boundary condition: true
name: _AI915649_1_c
is encoded by: hsa:AI915649
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaM cit e
type: Species
boundary condition: false
is: HMDB00094
initial amount: NaN
has only substance units: false
name: citrate(3-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16947
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaM o2 n
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
constant: false
type: Species
is: HMDB01377
boundary condition: false
is: CHEBI:15379
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: dioxygen

metaR RE2649C
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
name: RE2649
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000

metaM amet m
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:15414
is: HMDB01185
name: S-Adenosyl-L-methionine
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6dd50baf_5843_40d2_a07a_078fe3d32c10
initial concentration: NaN
name: ABCA1
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O95477
constant: false
is encoded by: hsa:19

metaR CYTK13n
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
name: cytidylate kinase (dCMP,dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9757dc15_c23d_4860_82a1_eebac34b6659
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
is: A6NN98
is encoded by: hsa:8898
initial concentration: NaN
initial amount: NaN
name: MTMR2

metaM retfa c
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol
initial concentration: 1.0
is: HMDB00305
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:50211
has only substance units: false
type: Species
constant: false

metaM gmp e
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01397
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: CHEBI:58115
name: GMP(3-)
constant: false

metaR DCYTt
reversible: true
reactant: MODEL1310110029#
name: deoxycytidine transport via diffusion
product: MODEL1310110029#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaR SPH1Pte
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: sph1p transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_5dd672e3_46f4_488f_af74_0b9d2a6df279
name: ACP5
is: P13686
is encoded by: hsa:54
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_b3374e08_4d2c_41cd_af91_303c5abc063b
is: Q06830
name: PRDX1
initial concentration: NaN
is encoded by: hsa:5052
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0570
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.3.3.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true

metaR XYLTt
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
name: Xylitol transport via passive diffusion
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is: SBO:0000185

metaR SERATB0tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Serine into the intestinal cells by ATB0 transporter
type: Reaction

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
constant: false
is: CHEBI:57817
name: sphinganine(1+)
is: HMDB00269
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_24f8d60e_791a_4a0c_afc0_4438baf2f9b8
boundary condition: true
name: ALDH1A2
initial amount: NaN
constant: false
is: F5H2Y9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8854
type: Species
has only substance units: false

metaR DPCOAtl
type: Reaction
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: dephospho-CoA transport from lysosome via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR r2119
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaR r0787
reversible: false
reactant: MODEL1310110029#
is described by: ECO:0000000
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110029#
type: Reaction
fast: false
modifier: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_83dfadb9_2eff_4ec5_8ab2_83dff9830be3
boundary condition: true
initial amount: NaN
has only substance units: false
name: NME1
is encoded by: hsa:4830
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is: P15531

http://identifiers.org/biomodels.db/MODEL1310110029#_c56b5e22_641c_4d2b_b679_9f9d9dd13042
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3283
name: HSD3B1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: P14060

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5f693d8c_4953_406a_9d67_ea44c3186e2e
is encoded by: hsa:22305
name: _22305_1_c
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR PRPNCOAHYDm
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
name: Propenoyl-CoA hydrolase (m)
is described by: ECO:0000134
modifier: MODEL1310110029#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM glyb c
is: CHEBI:17750
boundary condition: false
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
type: Species
name: glycine betaine
is: HMDB00043
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR CYTK1n
modifier: MODEL1310110029#
fast: false
type: Reaction
product: MODEL1310110029#
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000269

metaR r2196
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_80360f5b_8d7d_4d84_abab_6bc86a3ca4c8
is encoded by: hsa:8875
boundary condition: true
type: Species
name: VNN2
initial concentration: NaN
has only substance units: false
is: A8K7W0
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_aca66476_9156_413b_8306_34489fe127c0
initial concentration: NaN
is encoded by: hsa:122970
is: SBO:0000252
name: ACOT4
initial amount: NaN
is: Q8N9L9
type: Species
has only substance units: false
constant: false
boundary condition: true

metaR r2118
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110029#

metaR ACHEe
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.7
fast: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Acetylcholinesterase
type: Reaction
is: SBO:0000176

metaM 5aop m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17549
name: 5-Amino-4-oxopentanoate
boundary condition: false
is: C00430
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
is: HMDB01149
has only substance units: false
constant: false

metaR PGLer
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
name: 6-phosphogluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_15318a6d_dcf9_42d9_a046_26d17fb36c96
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1808
is: B4DR31
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: DPYSL2

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r2197
reversible: true
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR CYTK1m
fast: false
type: Reaction
is described by: ECO:0000134
name: cytidylate kinase (CMP),mitochondrial
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_792bfd26_42a3_4342_8852_980c464208a0
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10201
name: NME6
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: O75414

http://identifiers.org/biomodels.db/MODEL1310110029#_24383ec7_befe_4496_a079_004fa77e28d1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8659
name: ALDH4A1
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_5f295684_f3a8_4751_98c8_13c3d2998318
is: SBO:0000252
is encoded by: hsa:81490
has only substance units: false
name: PTDSS2
is: Q9BVG9
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM ocdca e
is: C01530
type: Species
is: CHEBI:25629
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: HMDB00827
name: octadecanoate (n-C18:0)
boundary condition: false

metaM pail4p hs n
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58178
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_eb63ad76_bc4a_4b51_85c3_c5e523768739
is: O95167
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:4696
name: NDUFA3
initial concentration: NaN
type: Species
is: SBO:0000252

metaR GTHPm
reversible: true
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
name: glutathione peroxidase, mitochondria
fast: false
type: Reaction
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_4a1f4add_8139_428a_84be_eb9191ab940c
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4645
is: SBO:0000252
is: Q9H6Y6
initial concentration: NaN
boundary condition: true
name: MYO5B

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR CSNt
fast: false
modifier: MODEL1310110029#
name: cytosine transport via facilated diffusion
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaR r0752
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:

metaR r0789
modifier: MODEL1310110029#
product: MODEL1310110029#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110029#

metaR r0575
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48

metaR TYRt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: L-tyrosine transport
fast: false

metaR r0002
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_bb367de7_4716_4900_bfff_99115f85eb64
type: Species
name: ACOT1
boundary condition: true
has only substance units: false
constant: false
is: E9KL42
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:641371

http://identifiers.org/biomodels.db/MODEL1310110029#_d2c840f6_4139_4fca_bff5_8c6583ab0ded
is: SBO:0000252
name: SOD1
is: P00441
is encoded by: hsa:6647
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaM 4fumacac c
constant: false
type: Species
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18034
is: SBO:0000247
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
is: HMDB01268
has only substance units: false

metaR r2198
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
reversible: true

metaM glyb e
is: CHEBI:17750
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: glycine betaine

metaR MALTSULtm
reversible: true
modifier: MODEL1310110029#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Malate:thiosulfate antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110029#_1eebcd90_7b4d_402c_bbe3_c813916f70c4
name: ALDH4A1
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P30038
is encoded by: hsa:8659
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM pmtcoa c
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: C00154
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:3454
is: HMDB01338

http://identifiers.org/biomodels.db/MODEL1310110029#_49e230eb_8700_453c_9e82_33d74c6cae68
initial amount: NaN
boundary condition: true
name: GSTZ1
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2954

http://identifiers.org/biomodels.db/MODEL1310110029#_bcc26118_f0e4_4b2d_97ad_595d79df553c
constant: false
is: O75251
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:374291
is: SBO:0000252
has only substance units: false
name: NDUFS7

metaR 3MOPt2im
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110029#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5c9e2414_bb36_4734_90c8_09abe12bc7d6
has only substance units: false
type: Species
is: C9JZ62
constant: false
is encoded by: hsa:641649
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: TMEM91

metaR r2116
kinetic law: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR ALOX5
name: Arachidonate 5-lipoxygenase
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.34
is described by: ECO:0000269
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110029#

metaR LEUTAm
fast: false
product: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000176
name: leucine transaminase, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_1d42483b_6864_4bf9_b9d6_72436728edad
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O95167
is encoded by: hsa:4696
constant: false
type: Species
name: NDUFA3
has only substance units: false

metaR r0788
reactant: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR r0753
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_10590eb3_3acc_4883_abbe_e84ca6161446
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA419122
has only substance units: false
name: _AA419122_1_c
initial amount: NaN

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR r2199
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM mercplaccys c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
initial concentration: 1.0

metaR CYTK9n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP),nuclear
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM hmbil c
is: SBO:0000247
is: HMDB01137
initial concentration: 1.0
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: CHEBI:57845
is: C01024
constant: false
has only substance units: false
name: Hydroxymethylbilane
boundary condition: false
initial amount: NaN
type: Species

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaM Rtotalcoa c
has only substance units: false
is: HMDB00904
is: SBO:0000247
name: R total Coenzyme A
type: Species
is: CHEBI:16349
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

metaM Lpipecol x
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:30913
name: L-pipecolic acid
initial amount: NaN
type: Species
is: HMDB00716

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM galside hs e
has only substance units: false
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
is: CHEBI:12947
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_f06d33c8_fd6c_42dd_8a24_0b305afac789
has part: P31040
has part: O14521
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6391
is: SBO:0000297
is encoded by: hsa:6392
constant: false
has part: Q99643
has part: P21912
boundary condition: true
is encoded by: hsa:6390
initial amount: NaN
type: Species
is encoded by: hsa:6389
has only substance units: false
initial concentration: NaN

metaM clpn hs c
name: clpn_hs[c]
type: Species
is: CHEBI:15589
notes: FORMULA: CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00156
constant: false

metaR 5ADTSTSTERONEte
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
fast: false
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction

metaR r0424
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
fast: false

metaR TPI
reversible: true
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
name: triose-phosphate isomerase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000176

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110029#
reversible: true
fast: false
modifier: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110029#
type: Reaction

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
is described by: ECO:0000304

metaM o2 c
constant: false
is: HMDB01377
initial concentration: 1.0
is: CHEBI:15379
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
name: O2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_741751a1_6f69_45c7_b698_565907ad7370
initial concentration: NaN
boundary condition: true
name: GCH1
type: Species
has only substance units: false
is encoded by: hsa:2643
is: SBO:0000252
constant: false
is: Q8IZH9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_31d2e92e_bfa6_4d03_b090_29389d21eaa6
constant: false
initial concentration: NaN
name: DUOX2
is: SBO:0000252
initial amount: NaN
is: Q9NRD8
boundary condition: true
type: Species
is encoded by: hsa:50506
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b350a3bb_6353_4472_9baa_7aed4de776bd
has only substance units: false
boundary condition: true
type: Species
constant: false
is: G5E960
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PLCB3
is encoded by: hsa:5331

metaM amp e
is: SBO:0000247
constant: false
is: HMDB00045
initial amount: NaN
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: C00020
type: Species
has only substance units: false
name: AMP
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_88380c1d_170d_48b2_9094_de18258d24e7
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:X63359
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _X63359_1_c
constant: false

metaR LEUTA
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110029#
fast: false
name: leucine transaminase
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269

metaM imp c
has only substance units: false
initial amount: NaN
is: C00130
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58053
initial concentration: 1.0
name: IMP
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110029#_1b2c41aa_4bec_4b77_a7a8_63681a93db43
has only substance units: false
name: BAAT
is encoded by: hsa:570
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: Q14032

metaM bhb m
boundary condition: false
name: (R)-3-hydroxybutyrate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:10983
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR THYOXt
type: Reaction
name: T4 transport via bicarbonate countertransport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
product: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9b8e9f59_e3fd_4189_8082_bf6753cb3610
boundary condition: true
initial concentration: NaN
is: O76082
constant: false
is encoded by: hsa:6584
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC22A5
has only substance units: false

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110029#

metaR r2114
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: L-alanine
is: HMDB00161
type: Species
boundary condition: false
is: CHEBI:16977

http://identifiers.org/biomodels.db/MODEL1310110029#_aa2d94da_7acb_4f13_b44e_9bb565206f34
is encoded by: hsa:10400
is: SBO:0000252
has only substance units: false
name: PEMT
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_a236011e_d2f0_4c35_b0c8_6931a77d3dcd
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6392
initial amount: NaN
is: SBO:0000252
name: SDHD
has only substance units: false
is: O14521

metaR PI45PLC
product: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: false

metaM mercplaccys e
initial amount: NaN
initial concentration: 1.0
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
type: Species

metaM galside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:12947
initial concentration: 1.0
has only substance units: false
type: Species
name: D-galactosyl-N-acylsphingosine

metaM ditp c
initial amount: NaN
boundary condition: false
name: dITP(4-)
is: HMDB03537
type: Species
has only substance units: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: CHEBI:61382
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0cc80c6f_c487_4223_9da8_61ad5a3738d4
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4717
is: SBO:0000252
is: O43677
name: NDUFC1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_de8aaa94_4075_4a49_8d35_15a97fe3e802
constant: false
boundary condition: true
name: SCD
is: O00767
is encoded by: hsa:6319
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r2113
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_2af1b0b9_b910_4bf8_8bc6_4249c0d07772
name: GLO1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2739
is: Q04760
has only substance units: false

metaR PRODt2r
fast: false
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: D-proline reversible transport via proton symport
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
type: Reaction

metaR r0579
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.13.11.19
kinetic law: MODEL1310110029#
fast: false
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reversible: true

metaR r0426
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.34
reactant: MODEL1310110029#
fast: false
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3

metaR ATP2ter
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#

metaR r0603
reactant: MODEL1310110029#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176

metaM damp c
is: HMDB00905
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: dAMP(2-)
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
initial amount: NaN

metaR r1669
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction

metaM cit m
initial concentration: 1.0
boundary condition: false
constant: false
is: C00158
name: Citrate
type: Species
is: SBO:0000247
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4259ac83_19ff_44eb_a083_38cf4645a2c0
initial amount: NaN
name: HSD17B10
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: Q99714
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3028

metaR r0829
modifier: MODEL1310110029#
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false
is: SBO:0000185

metaR DNDPt11m
kinetic law: MODEL1310110029#
type: Reaction
name: dADP transport via dGDP antiport
is: SBO:0000185
modifier: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110029#

metaR ABTti
name: L-arabinitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110029#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaR r2193
reversible: true
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110029#

metaM o2 e
name: O2
is: C00007
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
is: CHEBI:15379
is: HMDB01377
has only substance units: false

metaR r2195
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR 3MOX4HOXPGALDOX NADP
kinetic law: MODEL1310110029#
is: SBO:0000176
fast: false
product: MODEL1310110029#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reversible: true
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r2112
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110029#
fast: false
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM mescon m
boundary condition: false
is: HMDB00749
type: Species
is: CHEBI:36986
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247
name: Mesaconate

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR RE1254C
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110029#
name: RE1254
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
fast: false

metaM nad r
is: SBO:0000247
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false
is: HMDB00902
has only substance units: false
is: CHEBI:57540
boundary condition: false
initial amount: NaN
name: NAD(1-)
type: Species
initial concentration: 1.0

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR SQLSr
product: MODEL1310110029#
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Squalene synthase
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reversible: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.5.1.21
is: SBO:0000176

metaR RE2269E
fast: false
modifier: MODEL1310110029#
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_036db9b8_db48_4f7b_9fc3_70dd3c70bb0e
is: SBO:0000252
type: Species
has only substance units: false
name: GGT7
constant: false
is encoded by: hsa:2686
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: A0PJJ9

metaR r0578
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_63769084_9576_4b6a_aff0_beb40e26d0a7
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI601100
is: SBO:0000252
name: _AI601100_1_m
boundary condition: true
initial amount: NaN

metaR r0604
fast: false
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
modifier: MODEL1310110029#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is described by: ECO:0000000
type: Reaction

metaR NADtpu
name: NAD transporter, peroxisome
is: SBO:0000185
reactant: MODEL1310110029#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
fast: false
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_2c46dab0_c96d_4380_b79a_4672ef241202
is: SBO:0000252
type: Species
is encoded by: hsa:51703
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: ACSL5
is: Q9ULC5
boundary condition: true

metaM 5adtststerone e
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial concentration: 1.0
is: CHEBI:16330
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
is: HMDB02961

W3 CDTF: Thu Aug 30 19:15:07 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110029#_832cb01f_e5c9_4a68_b743_b812a2e2a075
initial concentration: NaN
type: Species
name: SLC20A2
is: B2RBR4
is encoded by: hsa:6575
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_cb3759b5_c35e_4f4c_9a3c_edf7a5d23fc2
initial amount: NaN
type: Species
is encoded by: hsa:LOC727762
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _LOC727762_1_m
boundary condition: true

metaR C4CRNe
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_9a65ea51_59ff_4977_bfad_23c6f34f9441
initial amount: NaN
name: INPP5B
constant: false
is: P32019
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3633
initial concentration: NaN

metaR GLYSARCNc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6d30a8b3_8e0b_47ae_a1e3_2bd13fbc0121
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:4846
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: A0S0A7
name: NOS3

metaM dhea c
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
boundary condition: false
is: HMDB00077
is: CHEBI:28689
initial concentration: 1.0
has only substance units: false

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: HMDB00032
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN
is: CHEBI:17759

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6b882f11_e14e_4d93_9e64_fcfd185ed9fb
boundary condition: true
initial amount: NaN
name: _AI091231_1_c
is encoded by: hsa:AI091231
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaM prostge1 e
constant: false
boundary condition: false
is: CHEBI:57397
initial concentration: 1.0
is: HMDB01442
type: Species
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
has only substance units: false
initial amount: NaN

metaR RE1845C
product: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
modifier: MODEL1310110029#
name: RE1845
reversible: true
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary

metaM HC01609 e
constant: false
name: UroporphyrinogenI
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
is: CHEBI:28766
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_52b4b73d_b32e_4202_850a_023727b680c3
is: SBO:0000252
type: Species
constant: false
is: E9KL44
has only substance units: false
name: HADHA
initial amount: NaN
is encoded by: hsa:3030
initial concentration: NaN
boundary condition: true

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_628f3283_d004_4327_9b3a_957246941dc7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:11238
name: CA5B
initial amount: NaN
constant: false
is: Q9Y2D0

metaR r2110
modifier: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true

metaM C02528 c
is: SBO:0000247
name: chenodeoxycholate
initial concentration: 1.0
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:36234
boundary condition: false

W3 CDTF: Thu Aug 30 19:15:07 BST 2012

metaR FATP3t
name: fatty acid electroneutral transport
fast: false
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
product: MODEL1310110029#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6bf9245c_5244_4cab_8a19_5a49098ca761
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AV727634
constant: false
is: SBO:0000252
name: _AV727634_1_c

metaR RNDR1
is described by: ECO:0000254
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110029#
name: ribonucleoside-diphosphate reductase (ADP)

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaM co e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
name: carbon monoxide
type: Species
is: CHEBI:17245
constant: false

metaR r0791
is: SBO:0000176
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110029#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110029#
fast: false

metaR r2111
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction

W3 CDTF: Thu Aug 30 19:15:07 BST 2012

metaR INSTt2r
modifier: MODEL1310110029#
is described by: ECO:0000269
name: inositol transport in via proton symport
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#

metaM co c
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB01361
boundary condition: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
name: carbon monoxide
type: Species
is: CHEBI:17245
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_0ab4daac_21a3_450d_a30a_f1b08d4470e9
is encoded by: hsa:6240
initial concentration: NaN
has only substance units: false
is: P23921
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: RRM1

metaR TALA
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
name: transaldolase
modifier: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2
is described by: ECO:0000000

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_c781f39a_5812_43ea_981b_e1dd0c61a9e7
initial amount: NaN
is encoded by: hsa:4832
is: Q13232
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NME3
type: Species
constant: false
has only substance units: false

metaM o2s c
initial concentration: 1.0
constant: false
is: HMDB02168
is: SBO:0000247
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:18421
name: superoxide

http://identifiers.org/biomodels.db/MODEL1310110029#_97ab81b3_1f5c_4908_ae01_efd63155662e
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: NDUFA4
type: Species
is: SBO:0000252
is encoded by: hsa:4697
initial concentration: NaN
is: O00483

metaR r0196
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
is: SBO:0000176

metaR RE3346C
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110029#
name: RE3346
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
modifier: MODEL1310110029#
type: Reaction

metaM mi1p D c
initial amount: NaN
is: CHEBI:58433
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
constant: false
is: HMDB02985
type: Species
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR ACCOAC
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR PCm
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
product: MODEL1310110029#
modifier: MODEL1310110029#
name: pyruvate carboxylase
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
reversible: false
is: SBO:0000176

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_0d7bfff7_388f_4a55_803f_d780820816be
has only substance units: false
name: SLC35A2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: P78381
boundary condition: true
is encoded by: hsa:7355
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_abb60318_558f_4af6_8793_1b931968a2eb
is encoded by: hsa:257202
boundary condition: true
name: GPX6
is: P59796
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

W3 CDTF: Thu Aug 30 19:15:07 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110029#_aa669fc0_796a_405b_97bb_63dcf05c69b0
name: CHAT
boundary condition: true
type: Species
is: SBO:0000252
is: D3DX95
is encoded by: hsa:1103
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR DHFtm
name: dihydrofolate reversible mitochondrial transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#

metaM C02528 e
boundary condition: false
is: HMDB00518
has only substance units: false
initial concentration: 1.0
name: chenodeoxycholate
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_ab32e2e4_765e_4c2b_9c32_82ca8dde1fc9
name: TREH
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:11181
is: O43280
type: Species

metaR ACACt2m
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is: SBO:0000185
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Acetoacetate mitochondrial transport via H+ symport
product: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110029#

metaR 5AOPtm
fast: false
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
type: Reaction
name: 5-Aminolevulinate mitochondrial transport
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM cdpdag hs c
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
is: SBO:0000247

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR r2335
is: SBO:0000185
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR r0434
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9d4ecbf1_63c4_44f1_a317_1b18896f6c1a
name: _728637_1_c
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:728637

metaM C05279 m
has only substance units: false
is: CHEBI:28387
boundary condition: false
is: HMDB11123
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

metaM galside hs g
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
is: CHEBI:12947
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaM glyb m
constant: false
is: CHEBI:17750
type: Species
has only substance units: false
is: HMDB00043
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247

metaM dolglcp L r
constant: false
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:15812

metaR MAN6PI
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
reversible: true
name: mannose-6-phosphate isomerase
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/5.3.1.8

http://identifiers.org/biomodels.db/MODEL1310110029#_52b8afb4_2272_4128_ba76_e5b704b945db
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: P23743
name: DGKA
is encoded by: hsa:1606
is: SBO:0000252
initial amount: NaN

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6d9d7596_54ad_4930_a887_012a9ce2977e
name: HADHB
initial concentration: NaN
is: P55084
constant: false
is encoded by: hsa:3032
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaM ala L c
name: L-alanine
has only substance units: false
is: SBO:0000247
is: CHEBI:16977
type: Species
is: HMDB00161
initial concentration: 1.0
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e27134b7_eafe_4e14_9ddc_7828fa663ff6
type: Species
name: NDUFA9
is encoded by: hsa:4704
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q16795
initial concentration: NaN
boundary condition: true

metaR ALAtN1
is described by: ECO:0000269
reactant: MODEL1310110029#
product: MODEL1310110029#
name: Alanine transport (Na, H coupled)
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false

metaM dhlam m
constant: false
is: SBO:0000247
is: CHEBI:17694
initial amount: NaN
is: HMDB00985
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
boundary condition: false
type: Species
name: dihydrolipoamide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_7a987473_5ccb_4315_86bb_3985a1ca0361
initial concentration: NaN
constant: false
is encoded by: hsa:D29675
has only substance units: false
is: SBO:0000252
type: Species
name: _D29675_1_e
boundary condition: true
initial amount: NaN

metaR PGISr
modifier: MODEL1310110029#
type: Reaction
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.4
is: SBO:0000176
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
name: Prostaglandin I2 synthase
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#

metaR PRPPS
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.1
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6e9ee5db_75d7_4388_b829_72c04586e499
is encoded by: hsa:224
is: P51648
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: ALDH3A2
initial concentration: NaN
has only substance units: false
constant: false

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM hpyr c
boundary condition: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01352
type: Species
name: 3-hydroxypyruvate
is: CHEBI:17180
has only substance units: false
initial amount: NaN

metaR 34DHPLACOX NADP
is described by: ECO:0000269
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: true
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reactant: MODEL1310110029#
fast: false

metaR r2332
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
fast: false
product: MODEL1310110029#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM mescoa m
constant: false
initial concentration: 1.0
boundary condition: false
name: Mesaconyl-CoA
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: C06028
is: SBO:0000247
is: CHEBI:27969
initial amount: NaN
type: Species
has only substance units: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r1563
is: SBO:0000185
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000

metaR r0973
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
name: Facilitated diffusion
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
type: Reaction

metaR ACALDt
type: Reaction
name: acetaldehyde reversible transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_305d438e_7162_46b3_882f_9bae037388ae
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000297
is encoded by: hsa:7991
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaR UPP3S
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.75
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
reversible: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
name: uroporphyrinogen-III synthase
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR r2535
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110029#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR DNDPt33m
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
name: dGDP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is: SBO:0000185

metaR GTHRDt
name: Glutathione transport into mitochondria
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_0747b863_8ece_43bc_9c0e_a5198ca27d83
type: Species
initial amount: NaN
is: O95470
is encoded by: hsa:8879
constant: false
has only substance units: false
initial concentration: NaN
name: SGPL1
boundary condition: true
is: SBO:0000252

metaR r2333
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#

metaM cytd m
is: CHEBI:17562
type: Species
name: cytidine
is: HMDB00089
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r1835
fast: false
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM met L c
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
is: CHEBI:16643
initial concentration: 1.0
is: HMDB00696
has only substance units: false
initial amount: NaN
name: L-methionine
is: SBO:0000247
type: Species

metaM frdp x
name: farnesyl pyrophosphate(3-)
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00961
boundary condition: false
initial amount: NaN
is: CHEBI:175763

metaM ala L e
name: L-alanine
is: CHEBI:16977
is: HMDB00161
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM mi134p c
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: SBO:0000247
is: HMDB01143
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaM 11 cis retfa e
is: SBO:0000247
has only substance units: false
boundary condition: false
name: fatty acid 11-cis-retinol
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00108
is: CHEBI:16236
initial amount: NaN
type: Species
constant: false

metaM nicrnt c
type: Species
name: Nicotinate D-ribonucleotide
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57502
initial concentration: 1.0
has only substance units: false
is: HMDB01132
constant: false
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110029#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM oaa c
is: CHEBI:3338
type: Species
is: C00036
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00223
is: SBO:0000247
name: Oxaloacetate
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110029#_6d2e0001_77ec_4f74_bc18_3a8b2b115242
is: Q53YE7
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4128
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: MAOA

metaR q10h2tc
kinetic law: MODEL1310110029#
fast: false
type: Reaction
name: transport of ubiquinol into cytosol
reactant: MODEL1310110029#
is described by: ECO:0000134
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR r1561
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_ece95e12_a988_4c5d_b02f_ebef610e1f93
is: SBO:0000252
is encoded by: hsa:AI620219
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _AI620219_1_c
boundary condition: true

metaM dhcrm hs c
initial amount: NaN
is: SBO:0000247
type: Species
name: dihydroceramide
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126

metaR GGT6
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Gamma-glutamyltransferase
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
type: Reaction
is: SBO:0000176
fast: false

metaM thp2c x
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
initial amount: NaN
is: CHEBI:16987
is: SBO:0000247
is: HMDB12130
constant: false
has only substance units: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110029#
fast: false

metaM 3odcoa m
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
boundary condition: false
name: 3-Oxodecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28528
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_cfde0276_46ed_4d4c_b6ef_74ab9774f2f7
is: SBO:0000252
is: E7EQF2
initial concentration: NaN
is encoded by: hsa:54677
initial amount: NaN
type: Species
boundary condition: true
name: CROT
constant: false
has only substance units: false

metaM prostge1 c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57397
constant: false
is: HMDB01442
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
name: prostaglandin E1(1-)
type: Species

metaR r0796
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
type: Reaction
product: MODEL1310110029#

metaR CYSGLTH
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000176
reactant: MODEL1310110029#
name: Glutathione:cystine oxidoreductase

metaM 2mcit e
initial amount: NaN
is: CHEBI:15598
name: 2-methylcitrate(3-)
is: SBO:0000247
is: HMDB00379
boundary condition: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

metaR PI34P5K
product: MODEL1310110029#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is: SBO:0000176

metaM ile L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
is: HMDB00172
is: CHEBI:17191
is: SBO:0000247
name: L-isoleucine
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR RE0935E
kinetic law: MODEL1310110029#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0935
product: MODEL1310110029#
modifier: MODEL1310110029#

metaR RE1233C
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
type: Reaction
name: RE1233
modifier: MODEL1310110029#
is: SBO:0000176

metaR NCCt
reactant: MODEL1310110029#
type: Reaction
fast: false
name: Na+-Cl- cotransport
modifier: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6559.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110029#
is: SBO:0000185

metaM chol c
initial concentration: 1.0
is: HMDB00097
is: CHEBI:15354
is: C00114
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR r1560
reactant: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2331
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaR r0193
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_27d3ce21_b51d_4522_a517_87acc2395762
name: CDS1
initial concentration: NaN
boundary condition: true
is: Q92903
type: Species
has only substance units: false
is encoded by: hsa:1040
constant: false
is: SBO:0000252
initial amount: NaN

metaM prostgh2 r
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: prostaglandin H2(1-)
is: SBO:0000247
is: CHEBI:57405
is: HMDB01381
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaR r0974
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: true
name: Active transport
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reactant: MODEL1310110029#
fast: false

metaR GGH 7THFe
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
fast: false
reversible: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction

metaM CE2433 m
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: http://identifiers.org/pubchem.compound/5041
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
constant: false
initial concentration: 1.0
boundary condition: false
is: C01936

metaR r1942
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
type: Reaction
name: Y+LAT2 Utilized transport

metaR r0797
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#

metaR r1567
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110029#
fast: false

metaM HC01162 c
is: CHEBI:58376
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_cbf7c494_b4fd_435d_b196_fbb7a40297ac
name: DUOX1
is: Q9NRD9
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:53905
constant: false
boundary condition: true

metaM Lcystin e
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16283
name: L-cystine
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00192
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_d2f09c79_4936_49a1_9327_807f8c073911
is encoded by: hsa:HG2846-HT2983
has only substance units: false
name: _HG2846_HT2983_1_m
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

metaR SERGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: L-Serine/Glutamine reversible exchange
reactant: MODEL1310110029#
is described by: ECO:0000304
fast: false
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
reversible: true

metaM HC02216 c
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:28922
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta

http://identifiers.org/biomodels.db/MODEL1310110029#_97295ad0_91c4_4dd7_a565_cd2a663cf434
is encoded by: hsa:1716
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: DGUOK
is: E5KSL6
has only substance units: false
is: SBO:0000252

metaR NDPK8
modifier: MODEL1310110029#
is: SBO:0000176
fast: false
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110029#
name: Nucleoside-diphosphate kinase (ATP:dADP)
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_4832df22_dbce_4dee_a314_c1287e23211f
is encoded by: hsa:788
initial concentration: NaN
name: SLC25A20
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: O43772
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b168fa16_000f_48ee_bb39_a5a7ef8555a2
constant: false
initial concentration: NaN
name: EARS2
is: SBO:0000252
is: Q5JPH6
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:124454
initial amount: NaN

metaR PNP
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110029#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110029#
name: purine-nucleoside phosphorylase
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
product: MODEL1310110029#
modifier: MODEL1310110029#

metaR r1566
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_f56c08de_4cc7_4b1c_8406_9d0c555de33f
name: ALDH3B1
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: P43353
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110029#_887b1726_aac7_4c2e_87b3_1ac900d5bb9e
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q96I99
constant: false
type: Species
is encoded by: hsa:8801
name: SUCLG2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_9ef2d9d1_cc5a_4f3d_b662_a42cc15b27d2
initial amount: NaN
has only substance units: false
is encoded by: hsa:5167
boundary condition: true
type: Species
is: P22413
is: SBO:0000252
name: ENPP1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_80d42784_160a_47db_aaf6_28471a4a4c99
is: SBO:0000252
is encoded by: hsa:23475
is: Q15274
initial amount: NaN
type: Species
name: QPRT
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r1671
product: MODEL1310110029#
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaM 2mcit c
is: SBO:0000247
constant: false
is: HMDB00379
name: 2-methylcitrate(3-)
type: Species
has only substance units: false
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15598

http://identifiers.org/biomodels.db/MODEL1310110029#_95622aab_283f_4af9_84ee_7dcdf0cb1d8e
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: NDUFV2
is: SBO:0000252
initial amount: NaN
is: P19404
is encoded by: hsa:4729

metaM peamn c
is: HMDB12275
initial amount: NaN
is: CHEBI:225237
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
name: 2-phenylethanaminium
is: SBO:0000247
type: Species
boundary condition: false

metaM chol e
is: HMDB00097
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
constant: false
type: Species
has only substance units: false
name: Choline
is: CHEBI:15354

metaR NDPK7
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dCDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaR UPPDC1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.37
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000176
reversible: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
reactant: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_86f32241_5e04_4fc7_bcae_fa51ff72de1b
type: Species
is: SBO:0000252
has only substance units: false
name: TM7SF2
is encoded by: hsa:7108
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O76062

metaM HC01405 m
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:28632
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM ditp n
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
is: CHEBI:61382
constant: false
initial amount: NaN
name: dITP(4-)
initial concentration: 1.0

metaR NDPK10n
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is described by: ECO:0000304
modifier: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110029#
reversible: true

metaR r1565
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
fast: false

metaM Lcystin c
is: HMDB00192
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
name: L-cystine

metaR r1670
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport

metaR VITD3t2
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
name: Vitamin D3 uptake
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a18eaf29_594e_4c78_b28f_c60f2340c24f
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC17A4
is: Q9Y2C5
is encoded by: hsa:10050
initial amount: NaN

metaM akg x
boundary condition: false
initial concentration: 1.0
is: CHEBI:16810
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-oxoglutarate(2-)
type: Species
constant: false

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_31137edb_ded5_4e9d_a95c_856c92e92aa2
name: ENTPD4
is encoded by: hsa:9583
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q9Y227
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_c20c07e8_3779_4e1d_a451_197038fe9636
initial concentration: NaN
is: O95861
name: BPNT1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:10380

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ac1553a4_b1cd_44af_b905_bb45b5334856
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:160728
name: SLC5A8
is: Q8N695
has only substance units: false

metaR RE2659R
name: RE2659
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000176
fast: false

metaM bhb c
constant: false
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2e516d85_0696_4631_9746_e8b16a58bfd6
is: SBO:0000252
type: Species
is encoded by: hsa:3939
initial amount: NaN
constant: false
is: P00338
name: LDHA
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_3df9cd98_97db_4d76_b306_ef1249ccf6c0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q7GXZ1
constant: false
name: ND6
is encoded by: hsa:4541
boundary condition: true
type: Species

metaR LYStm
reactant: MODEL1310110029#
name: Lysine mitochondrial transport via ornithine carrier
modifier: MODEL1310110029#
reversible: true
type: Reaction
product: MODEL1310110029#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM biliverd c
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial concentration: 1.0
is: CHEBI:57991
is: HMDB01008
constant: false
name: biliverdin(2-)
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

metaR DHCR72r
kinetic law: MODEL1310110029#
fast: false
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
is: SBO:0000176
product: MODEL1310110029#

metaR r0321
reactant: MODEL1310110029#
reversible: false
kinetic law: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
modifier: MODEL1310110029#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR r1898
reactant: MODEL1310110029#
fast: false
reversible: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
modifier: MODEL1310110029#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction

metaR r1564
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
reversible: true

metaR RE1516M
name: RE1516
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
fast: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaM met L e
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
is: CHEBI:16643
is: HMDB00696
constant: false
initial concentration: 1.0
has only substance units: false
name: L-methionine
boundary condition: false
initial amount: NaN

metaR NDPK8n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110029#
fast: false
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110029#_11694fb7_d81e_485a_8775_95a97d6306e6
type: Species
initial amount: NaN
is: SBO:0000252
is: P13716
has only substance units: false
is encoded by: hsa:210
initial concentration: NaN
constant: false
name: ALAD
boundary condition: true

metaR MAGt
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
fast: false
reversible: true
name: monoacylglycerol 2 transport
is described by: ECO:0000269

metaM thym c
has only substance units: false
is: CHEBI:17821
initial amount: NaN
name: Thymine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
is: C00178
type: Species

metaR PETOHMm hs
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reactant: MODEL1310110029#
name: phosphatidylethanolamine N-methyltransferase
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: false

metaM dhap e
is: HMDB01473
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: glycerone phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110029#_ca83fba6_48d9_46ee_9931_150a4cf56b73
initial concentration: NaN
name: NDUFA10
boundary condition: true
constant: false
is: O95299
is encoded by: hsa:4705
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR NDPK9
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269

metaM chol g
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: choline
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
boundary condition: false
is: HMDB00097
initial amount: NaN

metaM HC01522 c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Gentisate aldehyde
constant: false
type: Species
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_0a60ba52_2396_4513_950a_c44160cb8fa4
is: SBO:0000252
constant: false
has only substance units: false
name: RRM2B
boundary condition: true
initial amount: NaN
is encoded by: hsa:50484
initial concentration: NaN
type: Species
is: Q7LG56

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaM o2s e
boundary condition: false
initial amount: NaN
is: CHEBI:18421
name: superoxide
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
is: HMDB02168

metaR UMPK3n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
type: Reaction
name: UMP kinase (UTP),nuclear
reversible: true
is described by: ECO:0000269

metaM cytd e
is: CHEBI:17562
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
is: C00475
name: Cytidine
is: HMDB00089
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_40216007_edb9_4732_b902_855d8963e557
is encoded by: hsa:2593
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: GAMT
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_1ae93bd3_988e_47de_a616_a94d9ef6ca61
initial amount: NaN
has only substance units: false
name: _H77542_1_r
boundary condition: true
is encoded by: hsa:H77542
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR UMPK7
type: Reaction
name: UMP kinase (dGTP)
modifier: MODEL1310110029#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR NDPK4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
fast: false
reversible: true
name: nucleoside-diphosphate kinase (ATP:dTDP)
type: Reaction

metaR CERT1rt
reactant: MODEL1310110029#
name: ceramide transport protein
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000304
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110029#_293bc732_b96f_422c_92b1_4b5202c02954
initial amount: NaN
is: Q9NRX3
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:56901
name: NDUFA4L2
has only substance units: false
type: Species

metaR PROSTGE2t
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_1724c10c_e907_4eaf_9242_eb4dca5cb32b
is: SBO:0000252
name: PPA1
is encoded by: hsa:5464
constant: false
is: Q15181
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR RE1530C
product: MODEL1310110029#
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#

metaR CBR2
reversible: false
fast: false
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
kinetic law: MODEL1310110029#
name: Carbonyl reductase [NADPH] 1
modifier: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.189

metaM thbpt4acam n
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: HMDB02281
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247

metaM dhap c
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57642
name: Dihydroxyacetone phosphate
initial amount: NaN
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00111

http://identifiers.org/biomodels.db/MODEL1310110029#_964352e4_94c0_4a28_a77d_d8d23c8b6b40
is: P22830
constant: false
has only substance units: false
is: SBO:0000252
name: FECH
initial amount: NaN
is encoded by: hsa:2235
initial concentration: NaN
boundary condition: true
type: Species

metaR UMPK6
name: UMP kinase (dCTP)
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#

metaR NDPK3
name: nucleoside-diphosphate kinase (ATP:CDP)
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaM sql r
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: squalene
is: HMDB00256
is: CHEBI:15440
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR LALDO
modifier: MODEL1310110029#
fast: false
type: Reaction
product: MODEL1310110029#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c65f390d_11c5_4cf6_ba1b_c6666a70ec6d
has only substance units: false
is encoded by: hsa:1337
constant: false
boundary condition: true
type: Species
is: P12074
initial concentration: NaN
name: COX6A1
initial amount: NaN
is: SBO:0000252

metaR VALt5m
name: Valine reversible mitochondrial transport
product: MODEL1310110029#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110029#

metaM uri e
initial amount: NaN
is: CHEBI:16704
name: Uridine
is: C00299
initial concentration: 1.0
boundary condition: false
is: HMDB00296
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false

metaR r2443
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
type: Reaction
product: MODEL1310110029#

metaR 5ADTSTSTERONEtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
name: 5 alpha dihydrotesterone intracellular transport
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaR NADPHtru
is: SBO:0000185
reversible: false
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_800cdeac_9ba4_4fc6_a566_4bc6c0ef4f76
is encoded by: hsa:1351
initial amount: NaN
type: Species
boundary condition: true
name: COX8A
constant: false
is: Q53XN1
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR VALLAT1tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_58cd6cdf_31dc_4c04_a464_e8fbc52038cd
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:50
constant: false
name: ACO2
is: Q99798
has only substance units: false
is: SBO:0000252

metaR r1569
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110029#
fast: false
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_ea7ee730_39ba_4224_8bdf_3e5a6ce25c0f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4726
initial concentration: NaN
name: NDUFS6
constant: false
is: Q6IBC4
type: Species
boundary condition: true
initial amount: NaN

metaR r2338
product: MODEL1310110029#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_3b430d79_8849_42a2_89cf_151fadc1fbfa
is: E7EUT4
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:2597
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: GAPDH

metaR OCDCEAtr
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction

metaR ALCD2yf
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110029#
is described by: ECO:0000134
kinetic law: MODEL1310110029#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
type: Reaction
modifier: MODEL1310110029#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
reactant: MODEL1310110029#
is: SBO:0000176

metaR NDPK6
is: SBO:0000176
modifier: MODEL1310110029#
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dUDP)
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_95b24e4f_5ac1_40cf_a310_436ae01bcc46
has only substance units: false
name: NDUFS8
is: SBO:0000252
is encoded by: hsa:4728
boundary condition: true
is: O00217
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b6f7a7fe_b26e_4dbe_8fed_7e71d907cf71
type: Species
initial concentration: NaN
name: CHAT
is encoded by: hsa:1103
is: P28329
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM HC02216 e
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28922
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial concentration: 1.0
name: prostaglandin-f2beta

metaR UMPK5
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: true
name: UMP kinase (dATP)

http://identifiers.org/biomodels.db/MODEL1310110029#_415a7abd_d3d4_4d8c_a331_f27b7de68363
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: HPGDS
initial concentration: NaN
is encoded by: hsa:27306
is: O60760

http://identifiers.org/biomodels.db/MODEL1310110029#_e6896873_5447_4251_9f46_43aadd511f8a
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q5QPH3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55902
is: SBO:0000252
name: ACSS2

metaR r1568
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
fast: false

metaM amp x
initial amount: NaN
type: Species
is: SBO:0000247
is: C00020
is: HMDB00045
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:456215
name: AMP

metaR NDPK5
name: Nucleoside-diphosphate kinase (ATP:dGDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM HC01104 e
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
has only substance units: false

metaM nad c
is: http://identifiers.org/pubchem.compound/3305
is: C00003
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00902
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57540
initial amount: NaN
name: Nicotinamide adenine dinucleotide

http://identifiers.org/biomodels.db/MODEL1310110029#_ef794360_19df_4c6d_bef8_1862bd471515
type: Species
is: SBO:0000252
is encoded by: hsa:NOS2A
initial concentration: NaN
name: _NOS2A_1_c
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM uri c
is: SBO:0000247
initial amount: NaN
is: C00299
boundary condition: false
constant: false
is: CHEBI:16704
name: Uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
has only substance units: false
is: HMDB00296
type: Species

metaR UMPK4
is described by: ECO:0000269
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
modifier: MODEL1310110029#
name: UMP kinase (GTP)

http://identifiers.org/biomodels.db/MODEL1310110029#_26cbf64a_91c3_496f_a423_77f174d7c994
constant: false
initial concentration: NaN
is: P15104
name: GLUL
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2752
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_fdcc0c32_6ba6_4861_8598_b3544dd08a34
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80271
is: Q96DU7
has only substance units: false
name: ITPKC
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e6e48c83_e350_43dd_9924_a9f75ef3138f
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:H77542
initial concentration: NaN
has only substance units: false
name: _H77542_1_c

metaR CREATt4 2 r
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110029#

metaM o2s n
initial amount: NaN
is: CHEBI:18421
initial concentration: 1.0
name: superoxide
constant: false
has only substance units: false
type: Species
is: HMDB02168
boundary condition: false
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM atp m
boundary condition: false
is: C00002
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57299
is: HMDB00538
initial amount: NaN
is: SBO:0000247
name: ATP(4-)

http://identifiers.org/biomodels.db/MODEL1310110029#_7491ceb9_91ed_4b19_99f6_50da1b6a36c3
is: Q53F23
initial amount: NaN
is encoded by: hsa:6916
initial concentration: NaN
name: TBXAS1
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_485a01c2_91cc_464e_a56b_20483bef794e
initial amount: NaN
is encoded by: hsa:AI926493
constant: false
type: Species
name: _AI926493_1_c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR ACNAMtn
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
name: N-acetylneuraminate nuclear import
product: MODEL1310110029#

metaR ARABR
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
name: arabinose reductase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9ba18d23_daa3_4bea_b906_382f47a28ed5
is: SBO:0000252
is encoded by: hsa:160851
initial concentration: NaN
constant: false
name: DGKH
type: Species
is: Q86XP1
boundary condition: true
has only substance units: false
initial amount: NaN

metaR GLCMter
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
reversible: false
fast: false
reactant: MODEL1310110029#
type: Reaction
name: glucose transport via membrane vesicle
is: SBO:0000185

metaR r0399
reactant: MODEL1310110029#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
kinetic law: MODEL1310110029#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c7a8adfd_1c42_4111_91df_f6e0077c1504
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AA664770
initial amount: NaN
is: SBO:0000252
name: _AA664770_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_056a3b24_9a3a_4b75_8c33_807efdc16a29
name: SLC24A2
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9UI40
type: Species
is encoded by: hsa:25769
has only substance units: false

metaM h2o r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
type: Species
boundary condition: false
is: C00001
name: H2O
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110029#_04ef7ef7_736d_4899_9ddb_c8fcb2d536a8
is: Q59EA4
initial concentration: NaN
constant: false
name: PLD1
boundary condition: true
is encoded by: hsa:5337
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9a1b6319_ff3b_46ff_888d_646931821c6c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103
type: Species
constant: false
initial concentration: NaN
is: P28329
initial amount: NaN
boundary condition: true
name: CHAT

metaR ORNt3m
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
name: ornithine mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

metaM tyr L c
is: HMDB00158
type: Species
name: L-tyrosine
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM cl c
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
constant: false
name: Chloride
is: C00115
is: CHEBI:3966
initial concentration: 1.0
is: HMDB00492
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR PI45P3Kn
reactant: MODEL1310110029#
type: Reaction
fast: false
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate 3-kinase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reversible: false

metaR r0308
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
fast: false

metaR ALDD2x
reversible: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaM uppg3 c
name: Uroporphyrinogen III
has only substance units: false
is: CHEBI:57308
is: SBO:0000247
is: HMDB01086
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C01051
type: Species
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
constant: false

metaR FAS160COA
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110029#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_730b909e_f7cb_48e1_ac80_1d94aa1e27c4
has only substance units: false
type: Species
name: SLC23A1
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9963
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_85a132ce_5c54_4789_a33d_799acf2f509e
is: B2R6S5
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:51727
name: CMPK1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_13c4c6e2_a718_41c1_8fc8_47b5fdfb2111
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:64077
name: LHPP
is: Q9H008

metaR DNDPt14m
modifier: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
name: dUDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_e3c4f9fc_b4d8_4756_a350_2ac3fb77046b
initial concentration: NaN
type: Species
is encoded by: hsa:LOC647190
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: _LOC647190_1_c

http://identifiers.org/biomodels.db/MODEL1310110029#_9d5e874f_3258_4d9c_9d64_ab17162afa39
has only substance units: false
type: Species
is: P61457
initial amount: NaN
initial concentration: NaN
name: PCBD1
is encoded by: hsa:5092
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7de662f4_61dc_438e_842c_8f63b392a0eb
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: AK2
is: SBO:0000252
is encoded by: hsa:204
has only substance units: false

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110029#
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
name: L-Kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is described by: ECO:0000269
reactant: MODEL1310110029#

metaR r0630
type: Reaction
is described by: ECO:0000000
product: MODEL1310110029#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2

http://identifiers.org/biomodels.db/MODEL1310110029#_a889f531_5781_4e4d_9c4f_f4f6ff6e62fd
boundary condition: true
name: DDC
is: SBO:0000252
is encoded by: hsa:1644
initial amount: NaN
constant: false
has only substance units: false
is: Q53Y41
initial concentration: NaN
type: Species

metaR BTNt4i
product: MODEL1310110029#
reactant: MODEL1310110029#
name: Biotin uptake (antiport)
is described by: ECO:0000269
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ede0bb87_4711_43b9_bada_abd6453a4de2
is: O43252
name: PAPSS1
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9061
constant: false
has only substance units: false
is: SBO:0000252

metaR TSTSTERONEt
name: Testosterone transport
product: MODEL1310110029#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#

metaM atp n
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB00538
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110029#_6341f91a_cff6_4db2_ae7a_c1b5b758b5ef
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: Q99643
is encoded by: hsa:6391
initial amount: NaN
is: SBO:0000252
name: SDHC

metaM 2mb2coa m
is: SBO:0000247
is: HMDB02054
is: CHEBI:57337
constant: false
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 2-methylcrotonoyl-CoA(4-)

metaR r0580
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
modifier: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

metaM o2s m
is: CHEBI:18421
has only substance units: false
boundary condition: false
name: Superoxide anion
is: HMDB02168
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: C00704
is: SBO:0000247
initial amount: NaN

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_abb5affa_f386_4e11_ab99_1db859161937
name: NDUFV1
has only substance units: false
is: E5KNH5
type: Species
is encoded by: hsa:4723
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_b3cb8fec_9c33_44f9_a9ce_cb0d3eef447d
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:60490
boundary condition: true
initial concentration: NaN
is: Q96CD2
constant: false
initial amount: NaN
name: PPCDC

http://identifiers.org/biomodels.db/MODEL1310110029#_3d7bec13_156a_4108_9d89_1497e8229311
is encoded by: hsa:56895
is: SBO:0000252
initial amount: NaN
is: Q9NRZ5
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: AGPAT4

metaR MI1PP
reactant: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reversible: false
name: myo-inositol 1-phosphatase
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25

metaM cl e
constant: false
has only substance units: false
is: C00115
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: HMDB00492
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_1a363d02_4634_409c_8a37_6f83c0e5f73e
has only substance units: false
type: Species
name: PPT2
initial amount: NaN
is: Q9UMR5
initial concentration: NaN
is encoded by: hsa:9374
is: SBO:0000252
constant: false
boundary condition: true

metaR r0394
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is: SBO:0000176
product: MODEL1310110029#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110029#

metaM adp n
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: CHEBI:456216
is: HMDB01341
initial concentration: 1.0
has only substance units: false
name: ADP(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_4744126a_c819_422e_847c_3db5fa1c5530
name: PLCG1
constant: false
boundary condition: true
has only substance units: false
is: Q9UFY1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5335

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110029#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110029#
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#

metaM gtp c
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
has only substance units: false
is: CHEBI:37565
constant: false
initial concentration: 1.0
is: HMDB01273
name: GTP
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00044

metaR r1548
reversible: true
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DCYTDn
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110029#
is described by: ECO:0000254
product: MODEL1310110029#
type: Reaction
name: deoxycytidine deaminase, nuclear
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176
reversible: false
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0d037464_9eed_4dc1_8944_7730979232e9
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3098
has only substance units: false
is: P19367
name: HK1

metaM fad r
initial concentration: 1.0
is: HMDB01248
is: SBO:0000247
constant: false
name: Flavin adenine dinucleotide oxidized
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
is: CHEBI:16238

metaM xan c
name: Xanthine
constant: false
is: SBO:0000247
is: C00385
initial amount: NaN
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
type: Species
is: CHEBI:17712
has only substance units: false
boundary condition: false
is: HMDB00292
initial concentration: 1.0

metaM HC01115 c
has only substance units: false
name: NeuNGc
is: SBO:0000247
is: CHEBI:29025
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial amount: NaN
boundary condition: false

metaR CERT1gt
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110029#
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110029#_c4152470_94f6_4074_8af9_faae2ecf76fc
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23657
type: Species
boundary condition: true
name: SLC7A11:SLC3A2
has part: Q9UPY5
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110029#_49becbf4_899f_4b2d_8f6b_b1a1fd0e9ef3
has part: Q9UM01
is encoded by: hsa:9056
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:6519
name: SLC3A1:SLC7A7
initial amount: NaN
boundary condition: true
initial concentration: NaN
has part: Q07837
type: Species

metaM HC02180 c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:28728
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaM HC02210 c
has only substance units: false
initial amount: NaN
is: CHEBI:34939
boundary condition: false
name: prostaglandin-d3
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_473fe582_1c29_4667_869f_7e157ece8cb0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: A8K0I1
name: DGKH
type: Species
constant: false
is encoded by: hsa:160851

metaR NDPK1
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:GDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_8d330b60_13ad_4520_b036_c0bdb1bcb074
has only substance units: false
constant: false
is: SBO:0000252
name: CA8
is encoded by: hsa:767
initial amount: NaN
is: P35219
type: Species
boundary condition: true
initial concentration: NaN

metaM dump n
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
name: dUMP(2-)
constant: false
is: CHEBI:246422
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01409

metaR OCDCAtr
type: Reaction
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110029#
kinetic law: MODEL1310110029#
name: fatty acid transport via diffusion
is: SBO:0000185

metaM h2o m
initial amount: NaN
is: SBO:0000247
is: HMDB02111
has only substance units: false
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
boundary condition: false
is: C00001
is: CHEBI:15377
name: H2O
type: Species

metaM adp m
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01341
is: C00008
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: ADP
is: CHEBI:456216

metaR r0395
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
type: Reaction
reversible: true

metaM dpcoa e
is: SBO:0000247
type: Species
is: CHEBI:57328
is: C00882
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
constant: false
is: HMDB01373
name: Dephospho-CoA
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_edf7b863_20cc_418a_a1c9_7dc4b46ecb9b
is encoded by: hsa:R39999
has only substance units: false
initial concentration: NaN
name: _R39999_1_c
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR TXA2tr
reversible: true
name: thromboxane A2 intracellular transport
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
kinetic law: MODEL1310110029#

metaR r1549
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_060ddf68_c147_4845_bec6_0476543cc9e9
constant: false
is: SBO:0000297
initial amount: NaN
name: RRM1:RRM2
is encoded by: hsa:6241
initial concentration: NaN
is encoded by: hsa:6240
has part: P23921
boundary condition: true
has part: P31350
has only substance units: false
type: Species

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR PACCOAL
kinetic law: MODEL1310110029#
reversible: false
name: phenylacetate-CoA ligase
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR

metaR CH25H
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: cholesterol 25-hydroxylase
modifier: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.38
reversible: false

metaM 4hpro LT m
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
name: trans-4-hydroxy-L-proline
initial concentration: 1.0
is: HMDB00725

http://identifiers.org/biomodels.db/MODEL1310110029#_2950861b_4741_4bd0_87b8_047b3b4967c3
has only substance units: false
boundary condition: true
initial concentration: NaN
name: FOLR1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2348
type: Species

metaR NDPK2
name: nucleoside-diphosphate kinase (ATP:UDP)
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110029#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110029#

metaM btcoa c
name: Butanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01088
is: SBO:0000247
type: Species
constant: false
is: C00136
is: CHEBI:57371

http://identifiers.org/biomodels.db/MODEL1310110029#_246b4bdf_7dbc_4e56_8ad7_88490865401a
initial concentration: NaN
initial amount: NaN
is: P07864
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: LDHC
type: Species
is encoded by: hsa:3948

metaM dump m
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP(2-)
is: CHEBI:246422
has only substance units: false
type: Species
is: HMDB01409
initial concentration: 1.0
boundary condition: false

metaM h2o n
is: CHEBI:15377
has only substance units: false
constant: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: water
boundary condition: false

metaR EX c4crn
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ede838ed_13d9_4af9_b321_55fdb2921d39
initial amount: NaN
type: Species
is encoded by: hsa:291
name: SLC25A4
boundary condition: true
initial concentration: NaN
is: P12235
is: SBO:0000252
constant: false
has only substance units: false

metaM gtp e
is: HMDB01273
is: CHEBI:37565
name: GTP(4-)
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaR GAL3ST12
modifier: MODEL1310110029#
reversible: false
product: MODEL1310110029#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.11
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
name: Galactosylceramide sulfotransferase
fast: false
is: SBO:0000176

metaR ITPtn
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true
name: ITP nuclear transport
kinetic law: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_c9951575_2ebf_40c0_8d4d_53b98dcab305
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:197257
name: LDHD
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_1b9cee31_476d_4817_a2c5_05e7cf35a28a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:216
is: P00352
initial amount: NaN
name: ALDH1A1
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR SPODMn
product: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, nuclear
reversible: false
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
is: SBO:0000176
modifier: MODEL1310110029#

metaR CYTK10n
kinetic law: MODEL1310110029#
is described by: ECO:0000269
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
is: SBO:0000176
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM CE0693 m
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28387
is: SBO:0000247
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
type: Species
initial concentration: 1.0

metaR r0633
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.3
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
modifier: MODEL1310110029#
is: SBO:0000176

metaM HC02210 e
is: CHEBI:34939
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
has only substance units: false
name: prostaglandin-d3
constant: false
initial amount: NaN
boundary condition: false

metaR GLYC St
type: Reaction
name: L-glycerate export
fast: false
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185

metaR SUCD1m
modifier: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
fast: false
name: succinate dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#

metaR UMPK2
reversible: true
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: UMP kinase (CTP)
is described by: ECO:0000269
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaR MMSAD1m
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is: SBO:0000176
kinetic law: MODEL1310110029#
name: methylmalonate-semialdehyde dehydrogenase
modifier: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#

metaM dpcoa c
type: Species
is: SBO:0000247
is: CHEBI:57328
has only substance units: false
is: C00882
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
constant: false
boundary condition: false
is: HMDB01373
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_cce810ed_dbf4_467f_b9e5_bd69303dcf3e
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _AA526438_1_c
constant: false
is encoded by: hsa:AA526438
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_6c4bc018_3f1c_466f_8d1f_b163c03057f1
is encoded by: hsa:23236
is: Q9NQ66
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: PLCB1
has only substance units: false

metaR r0634
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_72e7dd3c_aea8_4a77_a30f_4f41d09e2c49
has only substance units: false
name: _AU149534_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AU149534

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM 4hglusa m
has only substance units: false
constant: false
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial amount: NaN
is: HMDB06556
initial concentration: 1.0
name: L-4-hydroxyglutamic semialdehyde
type: Species
boundary condition: false
is: SBO:0000247

metaM HC02180 e
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28728
initial amount: NaN
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_31b84e58_1b8e_419d_8ff6_8ac34ac534a2
is encoded by: hsa:1719
has only substance units: false
initial amount: NaN
name: DHFR
is: P00374
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR CHOLtu
is: SBO:0000185
product: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
reactant: MODEL1310110029#
type: Reaction
fast: false
modifier: MODEL1310110029#
name: Choline uniport

metaM so4 c
is: HMDB01448
constant: false
name: sulfate
is: CHEBI:16189
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0ceaa2b5_88aa_4eda_a4df_1163f2398938
boundary condition: true
constant: false
initial concentration: NaN
is: P26439
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HSD3B2
type: Species
is encoded by: hsa:3284

metaM h2o l
is: SBO:0000247
is: CHEBI:15377
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
type: Species
initial concentration: 1.0
boundary condition: false
name: water
initial amount: NaN
has only substance units: false

metaR PAIL HStn
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110029#
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000

metaR UMPK3
product: MODEL1310110029#
type: Reaction
fast: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: UMP kinase (UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR UGT1A10r
is: SBO:0000176
fast: false
product: MODEL1310110029#
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.4.1.17
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reversible: true

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR ASCBt4
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110029#
name: L-ascorbate transport via proton symport

metaR ACACT1rm
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_a2613515_2225_4109_ad97_103a7a07c92b
boundary condition: true
constant: false
name: AOC2
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:314
has only substance units: false

metaM tym c
is: SBO:0000247
is: CHEBI:327995
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
constant: false
initial amount: NaN
is: HMDB00306
initial concentration: 1.0
name: tyraminium

http://identifiers.org/biomodels.db/MODEL1310110029#_73253bad_2906_4b52_a1bf_a6d03b20c3eb
is: SBO:0000252
is encoded by: hsa:151531
initial concentration: NaN
constant: false
name: UPP2
initial amount: NaN
has only substance units: false
type: Species
is: O95045
boundary condition: true

metaM sphmyln hs c
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:15589
type: Species
boundary condition: false
name: sphmyln_hs[c]
notes: FORMULA: CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: HMDB00156

metaR C14STRr
is: SBO:0000176
reactant: MODEL1310110029#
name: C-14 sterol reductase
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110029#
is described by: ECO:0000134
type: Reaction
reversible: false

metaM atp e
initial amount: NaN
name: ATP(4-)
is: HMDB00538
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: C00002
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110029#_78a6f8b6_1499_4ae1_b3c0_0f5d659dca4d
initial concentration: NaN
is: Q14353
is encoded by: hsa:2593
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
name: GAMT
has only substance units: false

metaM sucsal m
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
constant: false
name: Succinic semialdehyde
initial amount: NaN
is: HMDB01259
boundary condition: false
has only substance units: false
is: CHEBI:57706
is: SBO:0000247
type: Species

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_d7a8883a_b665_453c_961f_28aa5e578b8d
boundary condition: true
is: Q13613
type: Species
is: SBO:0000252
constant: false
name: MTMR1
initial concentration: NaN
is encoded by: hsa:8776
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_52f8bbf6_eb63_4757_89be_7a08743ecd57
has only substance units: false
constant: false
is encoded by: hsa:29926
is: SBO:0000252
initial concentration: NaN
name: GMPPA
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_a8a05e9b_b853_4402_a916_92b039691d58
type: Species
name: COX5A
has only substance units: false
is encoded by: hsa:9377
boundary condition: true
constant: false
is: P20674
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM dctp n
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
type: Species
is: HMDB00998
is: SBO:0000247
is: CHEBI:16311
constant: false
name: dCTP
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM cala c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:11892
initial concentration: 1.0
is: HMDB00026
name: N-carbamoyl-beta-alaninate
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642

metaR HSD3B7P
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110029#
reversible: false
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000269
type: Reaction
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

metaR RE2147C
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: false
name: RE2147
is described by: ECO:0000000
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (54658.1) SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10702251 NOTES:
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_a677af2d_d9b8_4a87_b02e_72028f782432
name: SLC4A5
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9BY07
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57835
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0d9144ac_4cc5_4907_823f_7c47c4530784
has only substance units: false
is encoded by: hsa:28976
constant: false
initial amount: NaN
name: ACAD9
type: Species
boundary condition: true
is: Q9H845
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_d452477e_373d_4a80_b2bd_a4b070e74734
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: _PRO1933_1_m
boundary condition: true
is: SBO:0000252
is encoded by: hsa:PRO1933

http://identifiers.org/biomodels.db/MODEL1310110029#_09c4f243_8974_4794_9146_f337f3cd1cb2
boundary condition: true
has only substance units: false
name: NT5C3
is encoded by: hsa:51251
type: Species
initial amount: NaN
is: Q9H0P0
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_26ea72fc_fb4f_4595_876d_b5a47b0fd7e4
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:9162
is: O75912
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: DGKI

http://identifiers.org/biomodels.db/MODEL1310110029#_2d026421_e88a_4f00_a888_5d5726da958d
initial amount: NaN
is: E9PAY8
type: Species
boundary condition: true
is encoded by: hsa:8612
has only substance units: false
is: SBO:0000252
name: PPAP2C
initial concentration: NaN
constant: false

metaR DNDPt40m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: dUTP transport via dADP antiport
kinetic law: MODEL1310110029#
type: Reaction
fast: false

metaM stcoa c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01114
type: Species
is: SBO:0000247
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
is: C00412
constant: false

metaM cholate c
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
name: Cholate
is: HMDB00619
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:29747

metaM 3mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
initial concentration: 1.0
is: CHEBI:28654
type: Species
is: SBO:0000247
has only substance units: false
name: 3-methyl-2-oxopentanoate
initial amount: NaN
is: HMDB00491
boundary condition: false

metaR r1116
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
is: SBO:0000185
is described by: ECO:0000000

metaR PItx
type: Reaction
name: Phosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

metaM akg m
is: CHEBI:16810
type: Species
is: HMDB00208
name: 2-Oxoglutarate
is: C00026
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_251c39e9_8c41_4f48_958b_3460ba862cb5
type: Species
initial concentration: NaN
is encoded by: hsa:FLJ44968
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _FLJ44968_1_m
constant: false
boundary condition: true

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM h2o x
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
constant: false
initial amount: NaN
name: H2O
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0
is: HMDB02111

metaR DIDPtn
name: dIDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_d7481712_a3a7_4ace_a5ec_9f1d4c4b95c3
is encoded by: hsa:8867
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: SYNJ1
constant: false
is: C9JFZ1

metaM adp c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01341
name: ADP
is: C00008
boundary condition: false
is: CHEBI:16761
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN

metaM hmgcoa m
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
is: CHEBI:15467
is: HMDB01375

metaR RE2626C
is: SBO:0000176
name: RE2626
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaR NCNt
is: SBO:0000185
product: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
reversible: true
type: Reaction
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_8f5c581c_684f_4e62_b03d_1f83526b9bf9
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:60481
is: SBO:0000252
initial concentration: NaN
name: ELOVL5
constant: false
is: F6SH78

metaM h2o2 c
is: HMDB03125
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: Hydrogen peroxide
is: CHEBI:16240
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027

metaM r1p c
is: HMDB01489
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
constant: false
name: alpha-D-Ribose 1-phosphate
is: C00442
type: Species
is: CHEBI:57720

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110029#
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
fast: false
name: Postulated transport reaction
is described by: ECO:0000000

metaM pac c
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00209
constant: false
initial amount: NaN
is: CHEBI:18401
initial concentration: 1.0
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
name: phenylacetate

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: SBO:0000247
has only substance units: false
type: Species
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial amount: NaN
boundary condition: false
is: HMDB06842
constant: false
initial concentration: 1.0
is: CHEBI:16290

metaM dpcoa m
is: HMDB01373
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM icit c
name: Isocitrate
is: C00311
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00193
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9a15a2b2_8d47_447d_adfd_2e9de6a5a95b
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:27068
initial concentration: NaN
name: PPA2
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_c2e19627_80f2_4445_9535_d6bdc2da977c
is encoded by: hsa:57665
initial concentration: NaN
is: Q9HBH5
name: RDH14
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_0c519efe_bdb5_4046_a1b5_c059e8fc2929
has only substance units: false
is: Q16853
is encoded by: hsa:8639
name: AOC3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaR LPS2e
reversible: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.1.3
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110029#
name: lipase, extracellular

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110029#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
product: MODEL1310110029#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110029#
reversible: true
fast: false

metaR GTHOm
product: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
reversible: false
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000254
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_04ebe5d4_24ee_4a69_ae64_4302279b88ba
initial concentration: NaN
name: ADH1A
is encoded by: hsa:124
has only substance units: false
type: Species
is: P07327
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM nac e
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false
is: HMDB01488
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: C00253
initial concentration: 1.0
is: CHEBI:0
name: Nicotinate
initial amount: NaN

metaM retinal cis 9 c
constant: false
initial concentration: 1.0
is: HMDB01358
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
boundary condition: false
initial amount: NaN
name: all-trans-retinal
is: SBO:0000247
type: Species
is: CHEBI:17898

http://identifiers.org/biomodels.db/MODEL1310110029#_3da7886f_f52a_4c46_8a57_0232638f6dbd
has only substance units: false
type: Species
name: CAD
is encoded by: hsa:790
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P27708
boundary condition: true
constant: false

metaM HC00695 m
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:17432
boundary condition: false
constant: false
type: Species

metaR RTOTAL2t
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
name: RTOTAL2 transport
fast: false
is: SBO:0000185

metaR PHACCOAGLNAC
reversible: false
fast: false
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR RE3524R
reversible: true
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110029#
name: RE3524

http://identifiers.org/biomodels.db/MODEL1310110029#_db3676c2_c373_4759_8df2_f191ae36617f
type: Species
name: MYO5B
boundary condition: true
is: Q9H6Y6
is: SBO:0000252
is encoded by: hsa:4645
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_c716b401_f323_47ed_9e17_fe6147928995
is: SBO:0000252
type: Species
name: _AI378339_1_m
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AI378339
boundary condition: true
initial concentration: NaN

metaR KYN
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.3
reversible: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: kynureninase
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_3e46a593_253e_4149_b489_4bd9f084f5f3
name: SLC26A6
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:65010
initial amount: NaN
is: Q548A7

http://identifiers.org/biomodels.db/MODEL1310110029#_32cfe26b_5ade_4797_937a_3c3b80143639
initial concentration: NaN
boundary condition: true
type: Species
name: _AI191472_1_c
constant: false
initial amount: NaN
is encoded by: hsa:AI191472
is: SBO:0000252
has only substance units: false

metaM tcynt m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:18022
name: thiocyanate
constant: false
is: HMDB01453
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_d67285ae_a97d_4e5f_a3a8_0733f949fccd
is encoded by: hsa:53
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: E9PCI1
boundary condition: true
name: ACP2
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_82a6f08a_5991_4c79_8434_4429f082fecd
is: SBO:0000252
type: Species
is encoded by: hsa:AI222095
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AI222095_1_m

metaM o2s x
is: HMDB02168
name: superoxide
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
type: Species
is: CHEBI:18421
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR BILDGLCURt
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
reversible: true
product: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
kinetic law: MODEL1310110029#

metaR RE2666C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: RE2666
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#

metaM 2mpdhl m
constant: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
initial concentration: 1.0
is: CHEBI:17577
is: SBO:0000247

metaM gtp n
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: HMDB01273
constant: false
name: GTP(4-)
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR FADH2tru
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110029#
name: FADH2 transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_772407dd_459c_4140_aa54_96df2c900a00
boundary condition: true
has only substance units: false
name: ALDH7A1
type: Species
constant: false
initial amount: NaN
is: E7EPT3
is encoded by: hsa:501
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_904b72a4_964d_4f2a_a999_59b52b99e72e
is: SBO:0000252
is: P55084
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3032
name: HADHB

metaM crn x
is: HMDB00062
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:16347

metaM atp c
name: ATP(4-)
is: CHEBI:30616
is: C00002
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00538
type: Species
constant: false

metaM txa2 r
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57445
constant: false
is: HMDB01452
name: thromboxane A2(1-)

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM fad x
has only substance units: false
type: Species
is: CHEBI:16238
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01248
constant: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM tyr L e
is: CHEBI:17895
name: L-tyrosine
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM nac c
boundary condition: false
initial amount: NaN
is: HMDB01488
name: Nicotinate
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00253
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110029#_16fdd7e7_d555_4830_98e3_206522480c16
is: SBO:0000252
is encoded by: hsa:AI291895
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AI291895_1_c
initial amount: NaN

metaM gtp m
is: C00044
has only substance units: false
is: CHEBI:37565
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01273
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM thbpt4acam c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15374
is: HMDB02281
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false

metaM dpcoa l
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
name: 3'-dephospho-CoA(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01373
is: CHEBI:57328

metaR DURIK1
type: Reaction
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
name: deoxyuridine kinase (ATP:Deoxyuridine)
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false

metaR RDH2a
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
name: retinol dehydrogenase (9-cis,NADPH)
is: SBO:0000176
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_ddfcc1da_990b_4405_9fd4_d0a50dddf1cf
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P32119
is encoded by: hsa:7001
name: PRDX2
is: SBO:0000252
constant: false
type: Species

metaR COt
name: CO transporter via diffusion
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_f1ba5256_afa1_4e0f_a306_0e462f748fef
constant: false
initial amount: NaN
is encoded by: hsa:491
is: SBO:0000252
name: ATP2B2
boundary condition: true
type: Species
initial concentration: NaN
is: Q4J699
has only substance units: false

metaM paf hs e
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine

metaR r2029
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is: SBO:0000185

metaR r0584
kinetic law: MODEL1310110029#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
modifier: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM glyc3p x
is: HMDB00126
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57597
name: Glycerol 3-phosphate
constant: false
has only substance units: false

metaM CE2422 m
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: CHEBI:28387
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB11123
initial amount: NaN
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422

metaM dump c
boundary condition: false
has only substance units: false
constant: false
is: C00365
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
is: CHEBI:246422
initial concentration: 1.0
is: HMDB01409

http://identifiers.org/biomodels.db/MODEL1310110029#_383b7144_c1e8_4c97_8013_c25e43a210f0
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:1431
is: O75390
initial concentration: NaN
initial amount: NaN
name: CS
type: Species
boundary condition: true

metaM ptth c
is: CHEBI:16753
is: SBO:0000247
boundary condition: false
name: pantetheine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
constant: false
is: HMDB03426
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_de289f7b_dde8_48e8_a1cd_11d8174502ff
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1956
name: EGFR
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: P00533

metaM coa e
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
name: Coenzyme A
is: C00010
is: CHEBI:57287
is: HMDB01423
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_65cbfa87_7d6a_4612_b887_b8d5778485cb
is encoded by: hsa:6519
is: SBO:0000252
name: SLC3A1
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q07837

http://identifiers.org/biomodels.db/MODEL1310110029#_320883db_b8f3_46e7_822f_5cd74b5f6c90
is encoded by: hsa:AF080579
initial amount: NaN
name: _AF080579_1_c
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM paf hs c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
is: CHEBI:36707
boundary condition: false
has only substance units: false
constant: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_fb1ec2e3_2ff2_424a_8f80_011e751d78c5
is: E9PB82
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:3295
initial concentration: NaN
constant: false
name: HSD17B4
is: SBO:0000252

metaM HC02208 c
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
name: prostaglandin-d1
is: CHEBI:27696
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_ca057cd9_1c9d_4576_87ef_02aa3452a343
is: SBO:0000252
name: RPE
initial concentration: NaN
boundary condition: true
is: Q53TV9
constant: false
is encoded by: hsa:6120
type: Species
initial amount: NaN
has only substance units: false

metaM akg c
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: C00026
name: 2-Oxoglutarate
is: SBO:0000247
is: HMDB00208
is: CHEBI:16810
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_fab74bef_2abb_4f03_9dd0_a69ee3d74020
name: CA2
initial amount: NaN
is: P00918
is encoded by: hsa:760
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR r1619
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 13 cis retnglc c
name: 13-cis-retinoyl glucuronide
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:28870
type: Species
is: HMDB03141
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f0ba7cb2_9887_4d1e_9cd7_e8c05ee2b560
constant: false
type: Species
initial concentration: NaN
name: NT5C2
is: SBO:0000252
is: P49902
boundary condition: true
has only substance units: false
is encoded by: hsa:22978
initial amount: NaN

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_cc1a84bb_6a3a_442c_bb5f_fc01bc8cd583
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HSD3B2
is encoded by: hsa:3284
boundary condition: true
type: Species
is: P26439

http://identifiers.org/biomodels.db/MODEL1310110029#_2c772aa6_80ab_4b01_b46e_af6ae5f9eb22
is: E7EML0
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:9498
is: SBO:0000252
name: SLC4A8
constant: false

metaR r1801
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR RE1573M
fast: false
modifier: MODEL1310110029#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
name: RE1573
product: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM fad e
initial concentration: 1.0
is: CHEBI:16238
is: C00016
constant: false
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: Flavin adenine dinucleotide oxidized

metaM q10h2 c
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB13111
type: Species
name: Ubiquinol-10
boundary condition: false

metaM so4 m
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: CHEBI:16189
is: HMDB01448
has only substance units: false
name: sulfate

metaM sbt D c
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: CHEBI:17924
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
is: HMDB00247
is: SBO:0000247

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR r1090
kinetic law: MODEL1310110029#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_a4e42a81_1230_4d01_a335_aa6ac67c0f9b
is: SBO:0000252
initial concentration: NaN
is: Q6UWQ5
is encoded by: hsa:84569
name: LYZL1
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR CYTK2n
modifier: MODEL1310110029#
reversible: true
type: Reaction
name: cytidylate kinase (dCMP),nuclear
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a211d912_a0a3_4fe2_a8c8_ce6167fc75f8
is: P11310
type: Species
initial amount: NaN
name: ACADM
is encoded by: hsa:34
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR MI134P4P
type: Reaction
name: inositol-1,3,4-trisphosphate 4-phosphatase
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
reactant: MODEL1310110029#
fast: false

metaR DCK1n
modifier: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
reversible: true
reactant: MODEL1310110029#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110029#
is described by: ECO:0000269
name: Deoxycytidine kinase, nuclear (ATP)

http://identifiers.org/biomodels.db/MODEL1310110029#_acfce31b_2194_4017_88ce_8336e21ddf34
has only substance units: false
constant: false
is: SBO:0000252
name: NADSYN1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:55191
is: Q6IA69

metaR GLYSNAT5tc
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_d7949651_9aec_47b2_bc1a_fc165ff2455d
initial amount: NaN
is encoded by: hsa:54576
is: SBO:0000252
constant: false
is: Q5DSZ6
name: UGT1A8
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaR DAGK hs
product: MODEL1310110029#
name: Diacylglycerol phosphate kinase (homo sapiens)
fast: false
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110029#

metaM coa c
constant: false
type: Species
initial amount: NaN
name: Coenzyme A
initial concentration: 1.0
is: CHEBI:3312
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR ALCD21 L
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
modifier: MODEL1310110029#
name: alcohol dehydrogenase (L-1,2-propanediol)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.24

metaR CHOLD2m
reversible: false
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.99.1
name: choline dehydrogenase (FAD acceptor), mitochondrial
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
type: Reaction
reactant: MODEL1310110029#
fast: false

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaR r1551
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#

metaM 42A3HP24DB c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7956
is: HMDB04083
has only substance units: false
is: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR CO2ter
reversible: true
name: CO2 endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaM HC02208 e
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
is: CHEBI:27696
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM dhcholoylcoa x
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06895
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
is: CHEBI:27393

metaR r1617
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_ccf96bf7_08ce_4c17_8e11_b0a3ac900eb6
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: _100287639_1_c
boundary condition: true
is encoded by: hsa:100287639

metaM akg e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
is: HMDB00208
constant: false
is: CHEBI:16810
name: 2-oxoglutarate(2-)

http://identifiers.org/biomodels.db/MODEL1310110029#_27098331_cacb_4eb0_8cfc_3d5976320a70
type: Species
name: NDUFS4
is encoded by: hsa:4724
boundary condition: true
initial amount: NaN
is: O43181
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_650fcb73_f64f_454c_947a_eab087455909
is: O75106
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:314
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: AOC2

metaR r0960
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
reactant: MODEL1310110029#
fast: false

metaR r0464
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#

metaR RE1519M
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
name: RE1519
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110029#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d8b996e8_172f_42a2_a525_4e0934bbc639
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P10696
is encoded by: hsa:251
name: ALPPL2
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_3b82eb3b_b4f3_4a1c_8356_6b43876d9d7f
has only substance units: false
boundary condition: true
constant: false
name: PTGDS
initial concentration: NaN
type: Species
is: SBO:0000252
is: P41222
is encoded by: hsa:5730
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_10acbab2_5210_4cac_b23e_ad317649f515
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:4700
name: NDUFA6
constant: false
is: P56556
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR RE1531M
type: Reaction
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110029#
name: RE1531
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM fad c
is: CHEBI:16238
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
has only substance units: false
constant: false
name: Flavin adenine dinucleotide oxidized
type: Species
is: HMDB01248
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR SADT
is described by: ECO:0000269
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
type: Reaction
product: MODEL1310110029#
reversible: false
fast: false
name: sulfate adenylyltransferase

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01051
is: SBO:0000247
name: D-glyceraldehyde
initial concentration: 1.0
is: CHEBI:17378

metaR ACt2r
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
product: MODEL1310110029#
reactant: MODEL1310110029#
name: acetate reversible transport via proton symport
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM pail345p hs c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
has only substance units: false
constant: false
is: CHEBI:57836
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
type: Species
initial concentration: 1.0
initial amount: NaN

metaM cgly e
is: CHEBI:4047
name: L-cysteinylglycine
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00078
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_40d217e4_1286_41ad_9211_c369e157fd1a
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SYNJ1
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8867
is: O43426
constant: false

metaR GUAt
is described by: ECO:0000269
modifier: MODEL1310110029#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110029#
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR r1618
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_07dc1c46_2e90_48ec_8947_a8519393b4f0
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q6NVY1
name: HIBCH
has only substance units: false
boundary condition: true
is encoded by: hsa:26275
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_8667e70c_cf1f_4577_af95_a35179c28ab8
is: B3KVI7
name: IVD
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:3712
initial amount: NaN
is: SBO:0000252

metaR r0242
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaR r2381
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r0160
type: Reaction
is: SBO:0000176
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110029#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_c43d45c9_c225_4bd7_8b02_d6890457fd95
boundary condition: true
is: P06132
initial amount: NaN
name: UROD
has only substance units: false
is encoded by: hsa:7389
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f07ca80e_4da7_4893_8e3e_90ea402828bf
type: Species
constant: false
is: Q8NFW8
is: SBO:0000252
boundary condition: true
name: CMAS
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55907

metaR DHEAtr
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
kinetic law: MODEL1310110029#
name: Dehydroepiandrosterone transport
type: Reaction
is described by: ECO:0000269
product: MODEL1310110029#
fast: false

metaM mercppyr c
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: HMDB01368
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57678
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_a097b841_3896_43c6_8cb5_ae2664faa595
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC5A10
constant: false
type: Species
has only substance units: false
is encoded by: hsa:125206
is: A0PJK1
boundary condition: true

metaM duri n
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 2'-deoxyuridine
is: CHEBI:16450
is: HMDB00012

metaR CYTDK2m
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110029#
name: cytidine kinase (ATP), mitochondrial

metaR r1017
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
name: Vesicular transport
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110029#
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_12bfe4fc_8739_47f8_ac78_4e987438b6a5
has only substance units: false
name: GGT7
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2686
initial concentration: NaN
type: Species
initial amount: NaN
is: A0PJJ9

metaR r2380
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR CYSTA
fast: false
is: SBO:0000176
modifier: MODEL1310110029#
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
kinetic law: MODEL1310110029#
name: cysteine transaminase
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_31007289_87e7_4b06_8dd2_ab37aec9a45e
boundary condition: true
constant: false
is encoded by: hsa:4967
name: OGDH
initial amount: NaN
is: SBO:0000252
is: Q02218
type: Species
initial concentration: NaN
has only substance units: false

metaM Rtotal2coa c
is: C00055
boundary condition: false
is: HMDB00095
name: R total 2 coenzyme A
is: CHEBI:60377
has only substance units: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaR ASPTA
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110029#
product: MODEL1310110029#
reversible: true
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1

metaM 44mctr r
is: SBO:0000247
is: HMDB01023
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
constant: false
boundary condition: false
is: CHEBI:17813
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455

http://identifiers.org/biomodels.db/MODEL1310110029#_51e1c0f9_ec74_44dd_a188_a44a59361cd0
is encoded by: hsa:23057
boundary condition: true
type: Species
is: Q9BZQ4
name: NMNAT2
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR SERDGLNexR
name: D-Serine/Glutamine reversible exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110029#
is described by: ECO:0000304
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_692be08f_0a32_4ff1_bc06_3d8c7e1fe4e3
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: DLD
is: P09622
initial amount: NaN
type: Species
is encoded by: hsa:1738
constant: false

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR r1018
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
name: Transport reaction
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5e9e4899_2408_4212_a2d0_bf8478688c74
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:11136
boundary condition: true
is: P82251
name: SLC7A9

metaM cgly c
boundary condition: false
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00078
is: SBO:0000247
constant: false
initial amount: NaN

metaM for c
is: CHEBI:15740
is: C00058
is: HMDB00142
type: Species
name: Formate
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_11002811_3c72_4763_a7aa_67e7c00c348b
boundary condition: true
is encoded by: hsa:376497
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: SLC27A1
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_cf6e5a14_15a1_41af_83cb_624b9ae6da61
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: Q96KH8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6530
name: SLC6A2
has only substance units: false

metaR 3MOX4HOXPGALDOX
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110029#
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110029#_28fc635c_5c2a_460b_b33e_155143e58880
is: P51648
initial amount: NaN
name: ALDH3A2
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:224
boundary condition: true

metaR r2021
kinetic law: MODEL1310110029#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#
is: SBO:0000185
reversible: false
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction

metaR THP2Ctp
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: true
kinetic law: MODEL1310110029#

metaR CO2t
reversible: true
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction
is: SBO:0000185
name: CO2 transporter via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_8cd36bb3_f046_4ca2_a633_1e3e2ad72e70
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:89874
name: SLC25A21
is: G3V4L5
initial amount: NaN
boundary condition: true

metaR ALAGLNexR
fast: false
reversible: true
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110029#

metaR ITCOAL1m
modifier: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is described by: ECO:0000304
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110029#_8785a8c7_c533_49c3_990d_bb0296cd11c3
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6569
has only substance units: false
constant: false
is: Q7Z725
name: SLC34A1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_9837814d_397d_47cf_9a73_e09ebd9ae503
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: _642502_1_c
type: Species
is encoded by: hsa:642502
initial amount: NaN

metaM icit m
is: HMDB00193
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00311
type: Species
is: CHEBI:16087
name: Isocitrate
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR ASPPROASCT1
name: aspartate intake by system ASCT-1 transporter
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
fast: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000134

metaM sbt D e
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: HMDB00247
name: D-glucitol
initial concentration: 1.0

metaM andrstrn r
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species
has only substance units: false
is: HMDB00031
is: SBO:0000247
name: androsterone
boundary condition: false
is: CHEBI:16032

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ec335c28_11c6_4ed1_9f51_e957bb4788e3
is encoded by: hsa:343
has only substance units: false
name: AQP8
initial amount: NaN
boundary condition: true
constant: false
is: O94778
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_de510efb_6dde_4506_81ed_ed487f6e4ac8
type: Species
constant: false
is: P15121
is: SBO:0000252
name: AKR1B1
is encoded by: hsa:231
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_83fa36b7_7a01_4cf5_ac39_37a6fb74c6f1
name: _U37519_1_m
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR CDPDAGtm
kinetic law: MODEL1310110029#
name: intracellular transport
product: MODEL1310110029#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_15ee9d6f_35cc_4850_9d82_d864c58e67bf
is: SBO:0000252
name: GCDH
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2639
constant: false
type: Species
initial concentration: NaN
is: Q92947

http://identifiers.org/biomodels.db/MODEL1310110029#_5016c1d6_3584_46dd_bb1c_f1d4b9130a47
is: A6NFM2
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5831
is: SBO:0000252
has only substance units: false
name: PYCR1

metaR URATEt
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
name: urate export from cytosol
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_6738d9b1_56f4_48d7_9ad1_bbb557b7b22e
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: _H17063_1_m
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:H17063

metaM bamppald c
has only substance units: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
name: beta-Aminopropion aldehyde
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/7975
is: C05665
type: Species
initial concentration: 1.0
is: HMDB01106
initial amount: NaN

metaM txa2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
name: thromboxane A2(1-)
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01452
initial concentration: 1.0

metaM coa m
boundary condition: false
initial amount: NaN
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: CHEBI:57287
constant: false
is: C00010
has only substance units: false
type: Species
name: Coenzyme A
is: SBO:0000247

metaM mthgxl c
is: CHEBI:17158
type: Species
initial concentration: 1.0
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f541cc94_84df_453b_bfca_896890b2b12e
is: SBO:0000252
is encoded by: hsa:3293
boundary condition: true
constant: false
is: P37058
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: HSD17B3
type: Species

metaM glx x
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
constant: false
is: CHEBI:36655
is: HMDB00119
boundary condition: false
initial concentration: 1.0
name: glyoxylate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_1722d8b6_13e4_4ad8_bfff_f1f2e76ccd6e
boundary condition: true
initial amount: NaN
is encoded by: hsa:N63787
is: SBO:0000252
initial concentration: NaN
name: _N63787_1_c
constant: false
has only substance units: false
type: Species

metaR r1557
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000

metaM pail345p hs n
type: Species
has only substance units: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57836

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110029#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
reversible: false

metaR r1611
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 7dhf e
initial amount: NaN
boundary condition: false
is: HMDB06559
is: SBO:0000247
name: heptaglutamyl folate (DHF)
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species

metaR r0391
reversible: true
is: SBO:0000176
reactant: MODEL1310110029#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_06096722_c0af_4043_bd12_28042a0b0439
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1717
is: Q9UBM7
name: DHCR7
initial amount: NaN
has only substance units: false

metaR r2385
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110029#

metaM so4 e
initial amount: NaN
has only substance units: false
is: HMDB01448
type: Species
constant: false
initial concentration: 1.0
name: sulfate
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_588677a7_a0de_4ea7_860f_203ce351eca1
is encoded by: hsa:8527
name: DGKD
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: Q16760

metaR ITCOALm
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000212
type: Reaction
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_b6343a44_9059_4de5_bd65_3c3e2fe19471
initial concentration: NaN
name: BCKDHB
is encoded by: hsa:594
is: SBO:0000252
has only substance units: false
type: Species
is: P21953
initial amount: NaN
boundary condition: true
constant: false

metaM cholcoa c
is: CHEBI:57373
is: HMDB01374
initial amount: NaN
type: Species
name: choloyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR TCYNTt
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110029#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is described by: ECO:0000000

metaM icit x
has only substance units: false
is: HMDB00193
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: isocitrate(3-)
initial concentration: 1.0
type: Species

metaM coa n
constant: false
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
is: HMDB01423
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57287
name: coenzyme A(4-)

metaR MTHFDm
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR CHOLtg
is: SBO:0000185
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
name: choline intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
type: Reaction

metaR GLYt7 311 r
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110029#
is described by: ECO:0000006
is: SBO:0000185
product: MODEL1310110029#
fast: false

metaR RE3566C
product: MODEL1310110029#
name: RE3566
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110029#

metaR r1612
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
type: Reaction
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110029#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_30cc003d_0c6b_4158_9ae8_926353add6e9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51557
boundary condition: true
is: Q5TDP6
constant: false
type: Species
name: LGSN
initial amount: NaN

metaM cmpacna c
constant: false
is: HMDB01176
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_28141c2d_0411_4c85_a489_118ee2f779e4
initial amount: NaN
is: SBO:0000252
name: _AI620219_1_m
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI620219
constant: false
boundary condition: true

metaR r0245
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reversible: true
modifier: MODEL1310110029#

metaR r1556
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false

metaR r2384
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110029#
type: Reaction
fast: false
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR r0390
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110029#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000

metaR HPACtr
fast: false
name: hydroxyphenylacetate transport via diffusion
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB

metaR PROSTGD2t
reversible: true
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#
type: Reaction

metaM xol27oh r
is: HMDB02103
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17703
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol

metaM fad m
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
is: HMDB01248
is: SBO:0000247
is: CHEBI:16238
constant: false
initial amount: NaN
is: C00016
boundary condition: false
has only substance units: false
type: Species

metaR PSt3
name: phosphatidylserine transport
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaM ptth m
type: Species
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
initial amount: NaN
constant: false
is: SBO:0000247
name: pantetheine
has only substance units: false
boundary condition: false
is: HMDB03426

metaM lthstrl r
type: Species
initial amount: NaN
is: CHEBI:17168
is: SBO:0000247
boundary condition: false
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false
is: HMDB01170
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

http://identifiers.org/biomodels.db/MODEL1310110029#_9de7314c_dd94_4ced_bcd9_ee576f8324e3
initial amount: NaN
name: ACAA1
constant: false
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR GAPD
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.12
reversible: true
is: SBO:0000176
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000134
fast: false

metaM rbt e
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:15963

metaM 2oxoadp m
initial amount: NaN
is: SBO:0000247
is: CHEBI:57499
constant: false
name: 2-oxoadipate(2-)
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
boundary condition: false
is: HMDB00225
has only substance units: false
type: Species
initial concentration: 1.0

metaR UDPGALtg
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false
name: UDP-Gal Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#

metaR r1559
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM h2o g
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
is: CHEBI:15377
boundary condition: false
initial concentration: 1.0
is: HMDB02111
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM glyald c
is: SBO:0000247
is: CHEBI:17378
is: HMDB01051
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
is: C00577
boundary condition: false
name: D-Glyceraldehyde

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR PPPGOm
fast: false
name: protoporphyrinogen oxidase, mitochondrial
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.3.4
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_3a9a83a2_0382_42b8_98a3_17daa7489d46
boundary condition: true
initial concentration: NaN
constant: false
is: Q5FC00
is encoded by: hsa:765
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: CA6
type: Species

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR r0393
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

metaM for e
is: HMDB00142
initial amount: NaN
boundary condition: false
is: CHEBI:15740
constant: false
name: formate
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058

metaM atp x
is: CHEBI:57299
initial amount: NaN
is: C00002
is: SBO:0000247
is: HMDB00538
type: Species
name: ATP(4-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM tdcoa c
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
constant: false
type: Species
is: CHEBI:57385
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN

metaM coa l
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
type: Species
is: HMDB01423
is: CHEBI:57287
is: SBO:0000247
name: coenzyme A(4-)
initial amount: NaN

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110029#

metaR ALCD21 D
reactant: MODEL1310110029#
name: alcohol dehydrogenase (D-1,2-propanediol)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.99.24
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110029#

metaR BILIRUBtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reversible: true
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_e6357443_87b7_473c_92ca_1eb9a38797be
is: SBO:0000252
name: ACSL6
initial amount: NaN
boundary condition: true
is: B2RB13
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:23305

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR r0311
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
reactant: MODEL1310110029#

metaM btcoa m
boundary condition: false
type: Species
has only substance units: false
constant: false
is: C00136
name: Butanoyl-CoA
is: CHEBI:57371
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_5cb520dd_8b74_4a20_a3b8_50e9c73aea88
name: PPCDC
initial amount: NaN
is encoded by: hsa:60490
is: Q96CD2
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_85564037_ffe2_4049_a2f1_bae3eb94bcbb
is encoded by: hsa:1103
is: Q6LEN5
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: CHAT
type: Species
initial amount: NaN

metaR r0392
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: true

metaR r2382
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_39e26ae9_bf23_4eb6_bfb1_3812341a10ab
initial concentration: NaN
type: Species
name: ACOT7
is encoded by: hsa:11332
is: SBO:0000252
constant: false
is: O00154
initial amount: NaN
boundary condition: true
has only substance units: false

metaR TXASr
name: Thromboxane-A synthase
type: Reaction
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.5
product: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
reactant: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_2edb1818_70e5_4495_8dab_1b1610e8efb8
has only substance units: false
constant: false
name: NDUFA12
is: F8VQS7
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55967

http://identifiers.org/biomodels.db/MODEL1310110029#_21121d5c_77b1_43be_9f94_dbcadaff594b
name: NDUFV1
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4723
initial amount: NaN
is: E5KNH5

metaR SPODMx
fast: false
reversible: false
name: superoxide dismutase, peroxisome
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110029#
is: SBO:0000176
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_123724d8_e747_4187_9348_d852d1558317
name: CHAT
is encoded by: hsa:1103
constant: false
is: Q6LEN5
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM 4abut m
has only substance units: false
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species
is: C00334
initial concentration: 1.0
name: 4-Aminobutanoate
is: HMDB00112
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaM hco3 m
is: CHEBI:17544
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
name: Bicarbonate
is: HMDB00595
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: C00288

metaM rbt c
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
is: HMDB00508
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: D-ribitol
is: SBO:0000247
is: CHEBI:15963

metaM h2o e
is: HMDB02111
is: C00001
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
boundary condition: false
type: Species
name: H2O
is: CHEBI:15377
initial amount: NaN

metaR UMPK6n
name: UMP kinase (dCTP),nuclear
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110029#

metaR r2389
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
reversible: false

metaR 5MTHFt
fast: false
reversible: true
modifier: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
product: MODEL1310110029#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction

metaR ALDD2y
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110029#_dba4bdfd_42c2_4e95_842d_58cc5bc490e5
boundary condition: true
is: Q9H999
initial concentration: NaN
has only substance units: false
name: PANK3
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:79646
initial amount: NaN

metaR ADK1m
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
name: adenylate kinase, mitochondrial
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD

metaR r1615
modifier: MODEL1310110029#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110029#

metaR r1553
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
fast: false
reversible: true
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#

metaM focytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Ferrocytochrome C
has only substance units: false
type: Species
is: CHEBI:16928
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_fdb3a2ca_2faf_4c35_9ae4_a9c472530cb1
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR DNDPt36m
name: dGDP transport via dCDP antiport
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_67ba5635_bb86_45d7_a623_8bcf16bcaba8
has only substance units: false
is encoded by: hsa:5335
initial amount: NaN
is: P19174
boundary condition: true
name: PLCG1
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_b1ee1c96_d613_41b2_ab0f_28cc0fe59016
initial amount: NaN
constant: false
boundary condition: true
name: _AI480132_1_c
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI480132

metaR r1616
product: MODEL1310110029#
is: SBO:0000185
modifier: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_6a5a0506_392c_4d8d_89ad_3288c3312ffc
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q6IBC0
constant: false
is encoded by: hsa:3155
initial concentration: NaN
is: SBO:0000252
name: HMGCL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_72b49d85_dfdd_4171_aead_d552fe764cf4
is: P00374
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1719
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: DHFR

http://identifiers.org/biomodels.db/MODEL1310110029#_ca5f1f89_d84c_4fb4_b4d0_b18ba99d33e7
type: Species
boundary condition: true
is: B7Z2M9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8525
has only substance units: false
name: DGKZ
constant: false
is: SBO:0000252

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaM dgmp e
boundary condition: false
is: SBO:0000247
is: CHEBI:57673
type: Species
initial amount: NaN
is: HMDB01044
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)

metaR r1552
type: Reaction
kinetic law: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000

metaR r2388
modifier: MODEL1310110029#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
kinetic law: MODEL1310110029#

metaM dctp c
type: Species
initial amount: NaN
name: dCTP
initial concentration: 1.0
constant: false
is: CHEBI:16311
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
is: HMDB00998
has only substance units: false
boundary condition: false
is: C00458

http://identifiers.org/biomodels.db/MODEL1310110029#_26dda6b7_e57e_4c2a_8834_4fc61bfa0fb4
type: Species
is: Q96QE2
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC2A13
has only substance units: false
initial amount: NaN
is encoded by: hsa:114134

metaR r0853
kinetic law: MODEL1310110029#
fast: false
name: Facilitated diffusion
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_55cb1b59_976b_4eb4_b08f_4b7830bff18d
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI697028_1_m
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:AI697028
type: Species

metaM 13 cis retnglc e
has only substance units: false
initial amount: NaN
is: CHEBI:28870
is: HMDB03141
is: SBO:0000247
boundary condition: false
name: 13-cis-retinoyl glucuronide
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1

metaM mthgxl e
boundary condition: false
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
is: HMDB01167
initial concentration: 1.0
constant: false
is: CHEBI:17158
has only substance units: false
is: SBO:0000247
type: Species

metaR DNDPt16m
name: dUDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM txa2 c
name: thromboxane A2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01452
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ba8b361e_53bf_43ec_b3c9_b868c0bc595e
initial amount: NaN
initial concentration: NaN
has part: Q86U05
boundary condition: true
name: SLC7A8:SLC3A2
is: SBO:0000297
type: Species
constant: false
has only substance units: false
is encoded by: hsa:23428

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5df7d114_f630_4046_94b8_ee5131a0c2f4
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AU149534
name: _AU149534_1_e
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_48ede8fa_7af0_4dd1_a2d0_ed5d797947cc
name: LDHAL6B
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:92483
initial amount: NaN
is: Q9BYZ2

http://identifiers.org/biomodels.db/MODEL1310110029#_18fdcf55_cbae_4ec0_893c_e9ec8d617e87
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: O95497
boundary condition: true
is encoded by: hsa:8876
has only substance units: false
name: VNN1
initial amount: NaN

metaR GLYt4
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
name: glycine transport via sodium symport
kinetic law: MODEL1310110029#
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
fast: false
product: MODEL1310110029#

metaM atp r
has only substance units: false
is: CHEBI:57299
name: ATP(4-)
is: SBO:0000247
is: C00002
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00538
constant: false

metaR r2387
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
modifier: MODEL1310110029#
product: MODEL1310110029#

metaM h2o c
initial concentration: 1.0
is: C00001
initial amount: NaN
is: HMDB02111
constant: false
boundary condition: false
is: CHEBI:3303
is: SBO:0000247
type: Species
name: H2O
has only substance units: false
notes: FORMULA: H2O CHARGE: 0

metaR r1318
is described by: ECO:0000000
product: MODEL1310110029#
type: Reaction
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
reactant: MODEL1310110029#
fast: false

metaR HOXG
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000134
name: Heme oxygenase 1
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is: SBO:0000176
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.14.99.3

http://identifiers.org/biomodels.db/MODEL1310110029#_6364a325_c9d0_4de4_a9a5_2bbecaca01e0
initial amount: NaN
has only substance units: false
is encoded by: hsa:2030
is: Q99808
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC29A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_e245e32e_2f61_4b76_b1b9_7ef288750a69
initial amount: NaN
is encoded by: hsa:286016
name: TPI1P2
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaR r2308
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110029#
is: SBO:0000185

metaR PNTOte
name: Transport of (R)-Pantothenate
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000185
type: Reaction

metaM amet c
name: S-Adenosyl-L-methionine
has only substance units: false
is: C00019
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01185
constant: false
initial concentration: 1.0
is: CHEBI:15414
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

http://identifiers.org/biomodels.db/MODEL1310110029#_be957559_a17d_4821_a774_b400759f8b55
is: SBO:0000252
is: O75038
name: PLCH2
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9651
initial concentration: NaN
boundary condition: true

metaR CHOLtn
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
name: Choline transport, nuclear through pores
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#

metaR FRDPtr
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: lipid, flip-flop intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_05868360_b559_456e_9b29_8165b53a3655
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC35B2
is encoded by: hsa:347734
is: Q8TB61

metaM adp x
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
has only substance units: false
is: CHEBI:456216
type: Species
is: SBO:0000247
name: ADP(3-)
is: HMDB01341
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_a7a1a21f_cb09_43b6_ba04_1110ad28a3d0
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI694761
boundary condition: true
has only substance units: false
constant: false
name: _AI694761_1_c
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_88297f75_7b5a_45ce_9a77_15fa038c872f
name: ECI1
is encoded by: hsa:1632
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P42126
boundary condition: true
constant: false

metaR r2386
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110029#
reactant: MODEL1310110029#

metaR NDPK7n
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110029#
type: Reaction
is: SBO:0000176

metaM q10h2 e
is: HMDB13111
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species

metaR r1554
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
is: SBO:0000185
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false

metaR r1956
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110029#
reversible: false
fast: false
type: Reaction

metaM phaccoa c
initial concentration: 1.0
is: SBO:0000247
is: HMDB06503
boundary condition: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
has only substance units: false
initial amount: NaN
constant: false
name: phenylacetyl-CoA(4-)
type: Species
is: CHEBI:57390

metaR RE0344C
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is described by: ECO:0000000
type: Reaction
name: RE0344
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110029#
fast: false
is: SBO:0000176

metaR r1614
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110029#
fast: false
type: Reaction
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110029#_d7832d6d_aa1b_4cae_90d5_e7737cd885f5
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: _W74642_1_c
is: SBO:0000252
is encoded by: hsa:W74642
constant: false

metaR DHFR
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: dihydrofolate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
fast: false
is described by: ECO:0000254
reversible: true

metaR MI4PP
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
is described by: ECO:0000269
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110029#
fast: false
reversible: false
is: SBO:0000176

metaR PGK
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.2.3
is: SBO:0000176
name: phosphoglycerate kinase
reversible: true
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4d29f617_7851_4a19_9b27_427dee93e1b9
has only substance units: false
is: E9PB82
constant: false
name: HSD17B4
boundary condition: true
is encoded by: hsa:3295
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM gdp c
is: C00035
type: Species
name: GDP
initial concentration: 1.0
is: HMDB01201
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM 3mob e
boundary condition: false
is: HMDB00019
is: CHEBI:11851
initial amount: NaN
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_bc6179b0_5994_4466_a248_8febd8617036
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:3417
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O75874
type: Species
name: IDH1

http://identifiers.org/biomodels.db/MODEL1310110029#_ef18f62e_3881_4556_b2bc_4e1a517d9dd2
initial amount: NaN
name: PLCXD2
is encoded by: hsa:257068
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q0VAA5
type: Species

metaM creat c
is: CHEBI:16919
boundary condition: false
initial amount: NaN
name: creatine
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00064
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false

metaM crn c
is: CHEBI:16347
has only substance units: false
is: HMDB00062
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
name: L-Carnitine
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: C00318

metaM tre e
boundary condition: false
name: Trehalose
type: Species
is: C01083
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: SBO:0000247
is: HMDB00975
constant: false
initial concentration: 1.0
is: CHEBI:16551

metaM leuktrA4 e
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)
has only substance units: false
is: HMDB01337
type: Species

metaR NDP7g
type: Reaction
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110029#
is described by: ECO:0000269
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_be869c12_59b6_4396_a54c_7a92099d2cfb
has only substance units: false
constant: false
is: SBO:0000252
name: AFMID
initial concentration: NaN
boundary condition: true
is: Q63HM1
is encoded by: hsa:125061
type: Species
initial amount: NaN

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR CLOXAtex2
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000304
name: chloride transport via oxalate countertransport (2:1)
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_b47c2b94_909c_4070_b56f_03a86b8506dd
boundary condition: true
is: SBO:0000252
is: Q9NRR6
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56623
initial amount: NaN
constant: false
name: INPP5E
type: Species

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_fe7c3c21_0418_4f4c_934c_e891168fd5f4
is: SBO:0000252
initial concentration: NaN
is: E5KS60
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8803
type: Species
name: SUCLA2
boundary condition: true

metaR r0027
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110029#

metaM retinol 9 cis c
is: CHEBI:17336
type: Species
is: HMDB06217
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
name: 9-cis-retinol

http://identifiers.org/biomodels.db/MODEL1310110029#_36e1987b_0069_48de_b4e2_a934036538e4
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:203
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: P00568
name: AK1

http://identifiers.org/biomodels.db/MODEL1310110029#_b4618fd4_564e_4bd2_89a6_2b010b305d0e
boundary condition: true
name: NDUFAB1
has only substance units: false
initial amount: NaN
is: O14561
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4706

metaM dudp c
is: HMDB01000
name: dUDP
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
has only substance units: false
is: C01346
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:60471

metaM HC01496 m
constant: false
type: Species
initial amount: NaN
name: 2-Amino-3-oxoadipate
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28095

metaR LYStip
kinetic law: MODEL1310110029#
name: L-lysine transport, peroxisomal (irreversible)
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110029#
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110029#

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: SBO:0000247
initial concentration: 1.0
name: cis-deca-4-enoyl-CoA
is: http://identifiers.org/pubchem.compound/5041
is: C01936
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaM pan4p c
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:47942
is: SBO:0000247
boundary condition: false
is: C01134
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: HMDB01416
name: Pantetheine 4'-phosphate

metaR PGI
is version of: http://identifiers.org/ec-code/5.3.1.9
type: Reaction
modifier: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110029#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110029#
is: SBO:0000176
name: glucose-6-phosphate isomerase
reversible: true

metaM creat e
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
name: creatine
type: Species
is: SBO:0000247
is: HMDB00064
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16919

metaM crm hs r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
name: N-acylsphingosine
initial amount: NaN
type: Species
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110029#_888e59ee_8dbe_4566_8e13_4e844911bef8
type: Species
initial amount: NaN
is: SBO:0000252
name: DEGS1
is encoded by: hsa:8560
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_cf525e4e_48af_4215_8d0f_306e56f46125
boundary condition: true
constant: false
has only substance units: false
name: NDUFA8
initial concentration: NaN
initial amount: NaN
is: B1AM93
type: Species
is: SBO:0000252
is encoded by: hsa:4702

metaM dttp c
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
name: dTTP
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:37568
is: C00459
boundary condition: false
is: HMDB01342
initial amount: NaN

metaM gdp e
is: CHEBI:58189
initial concentration: 1.0
name: GDP(3-)
type: Species
boundary condition: false
is: HMDB01201
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
has only substance units: false

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16240
name: Hydrogen peroxide
is: C00027
has only substance units: false
is: HMDB03125

metaR PPDOy
modifier: MODEL1310110029#
is: SBO:0000176
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110029#
reversible: false
is described by: ECO:0000269
product: MODEL1310110029#

metaM leuktrA4 c
constant: false
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57463
boundary condition: false
type: Species
name: leukotriene A4(1-)
initial amount: NaN

metaR FMNAT
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
is described by: ECO:0000134
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
type: Reaction
fast: false
name: FMN adenylyltransferase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_e0ff8b95_4291_49aa_93ed_011be3602193
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC25A1
has only substance units: false
is encoded by: hsa:6576
is: SBO:0000252
is: D9HTE9
boundary condition: true

metaR r0594
fast: false
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
is: SBO:0000176
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_99335f3a_cd60_4a41_816d_423fecda536d
initial amount: NaN
name: NDUFAB1
is encoded by: hsa:4706
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: O14561

metaM Rtotal3 e
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: CHEBI:3554
is: SBO:0000247
name: R total 3 position
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00244
is: C00255
initial amount: NaN
type: Species

metaM acac e
initial amount: NaN
name: acetoacetate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: HMDB00060
type: Species
is: SBO:0000247
is: CHEBI:13705
has only substance units: false

metaM dgchol e
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00637
has only substance units: false
name: glycochenodeoxycholate
is: CHEBI:36252
is: SBO:0000247

metaM pmtcrn x
is: SBO:0000247
name: L-palmitoylcarnitine
is: HMDB00222
is: CHEBI:17490
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_7c5ec635_8ad3_4ef9_9108_b2c72c8f58a1
has only substance units: false
is encoded by: hsa:29085
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PHPT1
is: Q9P019

http://identifiers.org/biomodels.db/MODEL1310110029#_e156f983_4d18_457c_9278_a1f0ecd305fe
is: SBO:0000252
boundary condition: true
is encoded by: hsa:280
name: AMY2B
is: P19961
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaM dttp e
type: Species
initial concentration: 1.0
is: HMDB01342
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)
constant: false
is: CHEBI:37568
is: SBO:0000247
initial amount: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
reactant: MODEL1310110029#
modifier: MODEL1310110029#
name: RE0926
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM andrstndn r
is: CHEBI:16422
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB00053
boundary condition: false
name: androst-4-ene-3,17-dione

http://identifiers.org/biomodels.db/MODEL1310110029#_5039612c_ec9c_4e08_8283_d600c27216ac
type: Species
is: Q16348
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6565
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: SLC15A2

metaR RE3421R
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE3421
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110029#
reversible: true

metaR r1538
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110029#
fast: false

metaM ser L c
is: CHEBI:17115
constant: false
boundary condition: false
name: L-serine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_a696e47a_9399_48dc_b1e8_179105122436
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P30838
initial concentration: NaN
name: ALDH3A1
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110029#_971ae868_3e05_44ec_a919_4f0b208ee176
name: CDS2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: O95674
is encoded by: hsa:8760
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_db1b3ed3_ca84_4553_92ba_2ba7e4baba62
is: P49189
initial amount: NaN
name: ALDH9A1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:223
type: Species
is: SBO:0000252

metaR RE1525M
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: RE1525

http://identifiers.org/biomodels.db/MODEL1310110029#_80eece2c_4dfa_4cf1_87c8_3c3574dbabb4
initial amount: NaN
constant: false
is: P23677
boundary condition: true
is encoded by: hsa:3706
type: Species
is: SBO:0000252
initial concentration: NaN
name: ITPKA
has only substance units: false

metaR OCCOAtm
name: Octanoyl-CoA transport, diffusion
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110029#_333db56a_131a_4a72_85da_d08eca3f07f1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: GPT2
is: Q8TD30
is encoded by: hsa:84706
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r0734
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110029#
type: Reaction
reversible: false
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR r0384
product: MODEL1310110029#
is described by: ECO:0000000
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110029#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110029#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_f944d672_1e50_4921_b6b3_d2b58f6db566
type: Species
boundary condition: true
initial concentration: NaN
name: LDHAL6A
is encoded by: hsa:160287
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q6ZMR3
constant: false

metaM q10h2 m
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
constant: false
has only substance units: false
initial concentration: 1.0
name: Ubiquinol-10
type: Species
boundary condition: false
is: HMDB13111

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110029#
fast: false
name: L-carnitine reversible transport
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#

metaM 12ppd R c
has only substance units: false
is: HMDB01881
initial amount: NaN
type: Species
name: (R)-propane-1,2-diol
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28972
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
boundary condition: false

metaR GLUDym
type: Reaction
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110029#
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_a1bd3bc3_c9ab_4e41_9062_51b6239658ac
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8802
has part: P53597
boundary condition: true
is encoded by: hsa:8801
has part: Q96I99
name: SUCLG2:SUCLG1
has only substance units: false
is: SBO:0000297
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_61d1e461_7d54_4252_8b43_69f0a9c0eb41
type: Species
initial amount: NaN
is encoded by: hsa:4711
has only substance units: false
name: NDUFB5
is: O43674
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR FE2tm
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
fast: false
name: iron (II) transport
is described by: ECO:0000000
product: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
is: SBO:0000185
type: Reaction

metaM CE5586 c
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58732

metaR DHPM1
reactant: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.5.2.2
kinetic law: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
type: Reaction
name: dihydropyrimidinase (5,6-dihydrouracil)
is described by: ECO:0000269
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_6ec2b3cd_b592_41f5_a14d_fcd24d34d907
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2629
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GBA
is: B7Z6S1
constant: false
type: Species

metaM acac m
has only substance units: false
is: HMDB00060
constant: false
name: acetoacetate
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:13705
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM ppa c
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00237
has only substance units: false
is: CHEBI:17272
type: Species
initial concentration: 1.0
name: propionate

metaR PI4PP
type: Reaction
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
name: phosphatidylinositol-4-phosphate 4-phosphatase
is: SBO:0000176
reversible: false
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_382796bb_4b7a_48cf_8891_8317f81d1dc1
type: Species
is encoded by: hsa:26289
is: Q9Y6K8
boundary condition: true
initial concentration: NaN
constant: false
name: AK5
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM Rtotal3 c
is: CHEBI:16349
is: HMDB00904
type: Species
name: R total 3 position
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1

metaR r0735
modifier: MODEL1310110029#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR LYSOXp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal
reversible: false
fast: false
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#

metaM retn r
type: Species
constant: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: all-trans-retinoate
is: HMDB01852
boundary condition: false
is: SBO:0000247

metaR r0385
reactant: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110029#
reversible: false

metaM 2mp2coa m
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01011
name: 2-Methylprop-2-enoyl-CoA
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:27754
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_4a6b7ead_6ed4_4cfe_a58c_90895a94456a
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AI440329
initial concentration: NaN
boundary condition: true
type: Species
name: _AI440329_1_r
initial amount: NaN

metaM Sfglutth c
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: S-formylglutathionate(1-)
is: HMDB01550
has only substance units: false
is: CHEBI:57688
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
type: Species

metaR CYTDt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110029#
type: Reaction
reversible: true
is described by: ECO:0000269
name: cytidine facilated transport in cytosol
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ba9a93ff_dff7_41a1_8e7f_1ebb80c423b4
is encoded by: hsa:55350
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: VNN3

metaR CYTK11n
product: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: cytidylate kinase (dCMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0097
reversible: false
type: Reaction
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_08b81ced_366e_45e0_a83e_97ba81b33586
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AGPAT7
type: Species
boundary condition: true
name: _AGPAT7_1_c

http://identifiers.org/biomodels.db/MODEL1310110029#_4f6bb061_373b_4890_80ec_da6b8ec9f566
is: Q8NFF5
is: SBO:0000252
is encoded by: hsa:80308
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: FLAD1

http://identifiers.org/biomodels.db/MODEL1310110029#_9c8d9b5b_e1ec_4de0_8e79_bdf8f47e1acb
type: Species
initial amount: NaN
is encoded by: hsa:AI090874
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI090874_1_c
has only substance units: false

metaR r0591
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is: SBO:0000176
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_1d4b8295_b3bb_4ca9_bb7b_52c8ee97baf4
type: Species
initial concentration: NaN
name: NDUFV3
is: SBO:0000252
is encoded by: hsa:4731
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_3e03c538_9bef_485e_8828_3cdc7a5a7439
type: Species
is: P22392
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NME2
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110029#_f1ce4ab6_6885_4d9e_93a1_1643511f9ecd
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4720
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: B7Z792
name: NDUFS2

http://identifiers.org/biomodels.db/MODEL1310110029#_14483888_2409_4bd9_bbec_648b92a97274
is: Q6P1K9
name: PANK2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80025
constant: false
initial amount: NaN
type: Species

metaR DRPA
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false
fast: false
name: deoxyribose-phosphate aldolase
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_08dd97e1_378d_4398_8c98_39b0ad1b9086
is encoded by: hsa:2653
is encoded by: hsa:275
has only substance units: false
is encoded by: hsa:2731
name: DLD:GCSH:GLDC:AMT
constant: false
has part: P23434
has part: P09622
boundary condition: true
is: SBO:0000297
initial amount: NaN
has part: P48728
is encoded by: hsa:1738
initial concentration: NaN
has part: P23378
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_be1f2912_2baa_43b3_8d8e_66e03af5088e
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7001
constant: false
initial concentration: NaN
name: PRDX2
type: Species

metaM ppa e
initial amount: NaN
name: propionate
is: SBO:0000247
boundary condition: false
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4994a257_d2dd_415f_8bd4_80aee96ba2ac
name: SLC6A5
boundary condition: true
constant: false
is: Q9Y345
is encoded by: hsa:9152
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM coa r
type: Species
is: C00010
is: CHEBI:57287
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
boundary condition: false
name: Coenzyme A
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_794a724d_ca0f_47ba_9598_56c76a47767d
name: AK2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:204
type: Species
has only substance units: false
constant: false
boundary condition: true
is: P54819
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_169c8721_fef8_4c41_923c_d7446f1edbc6
is: Q9UIG8
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:28232
boundary condition: true
name: SLCO3A1
constant: false

metaR BHBtm
type: Reaction
reactant: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
fast: false
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
kinetic law: MODEL1310110029#

metaM bilglcur c
is: SBO:0000247
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
is: CHEBI:57767

metaM HC02203 e
is: CHEBI:27820
initial concentration: 1.0
name: prostaglandin-a2
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
boundary condition: false
constant: false

metaR TYRTA
fast: false
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110029#
name: tyrosine transaminase
kinetic law: MODEL1310110029#
reversible: true
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110029#_85b15384_b734_40e6_9db1_44b94746822e
has only substance units: false
initial amount: NaN
is: Q9Y6M9
initial concentration: NaN
type: Species
is encoded by: hsa:4715
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFB9

metaR r0590
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000

metaM pan4p e
is: HMDB01416
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
type: Species
has only substance units: false
is: SBO:0000247
is: C01134
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b098184f_27a6_451b_8065_ecfa1f9af95f
initial amount: NaN
has only substance units: false
is: P24752
initial concentration: NaN
is encoded by: hsa:38
boundary condition: true
name: ACAT1
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_ab20575a_5203_4cbc_bf5c_54de8299ccaf
is: SBO:0000252
is: Q9P0J0
initial concentration: NaN
type: Species
name: NDUFA13
is encoded by: hsa:51079
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a3d6dfef_2621_4ed8_bd83_adb4021bc1cd
name: RDH14
has only substance units: false
boundary condition: true
is encoded by: hsa:57665
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q9HBH5

metaR RETNGLCt2
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
name: retinoyl glucuronide efflux (13-cis)
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:14704335,PMID:2324641 NOTES:IT
reactant: MODEL1310110029#

metaM prostgd2 c
initial amount: NaN
is: CHEBI:57406
name: prostaglandin D2(1-)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB01403
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaM HC02202 e
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin A1(1-)

metaR ABUTD
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reversible: false
name: Aminobutyraldehyde dehydrogenase
reactant: MODEL1310110029#
is described by: ECO:0000269
fast: false
product: MODEL1310110029#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM dttp n
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: C00459
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01342
constant: false
initial amount: NaN
name: dTTP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_ce23b968_b8ca_4827_8b88_df70e0fe7952
is encoded by: hsa:3030
name: HADHA
boundary condition: true
is: E9KL44
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR r1257
product: MODEL1310110029#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
is: SBO:0000176
name: EC:6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110029#_433acf03_f201_4599_b045_a587200846a0
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:586
initial amount: NaN
name: BCAT1
is: P54687
is: SBO:0000252

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
name: b-ureidopropionase

http://identifiers.org/biomodels.db/MODEL1310110029#_95e38fb5_4b6a_4981_8a0e_28ffd5ea2b58
is: B7Z4Y6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:249
name: ALPL
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_0daed76a_3d55_4bc8_9200_787f96067e2c
initial amount: NaN
is: Q7GXY9
boundary condition: true
constant: false
initial concentration: NaN
name: ND2
is encoded by: hsa:4536
has only substance units: false
is: SBO:0000252
type: Species

metaR r0730
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110029#
is: SBO:0000176
reversible: false
modifier: MODEL1310110029#
type: Reaction
fast: false
reactant: MODEL1310110029#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
kinetic law: MODEL1310110029#

metaR FCLTm
reversible: false
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.99.1.1
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false
modifier: MODEL1310110029#
name: Ferrochelatase, mitochondrial

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM cdp n
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
is: HMDB01546
is: CHEBI:58069
is: SBO:0000247
initial amount: NaN

metaM 3hpp m
name: 3-hydroxypropionate
constant: false
is: HMDB00700
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16510

metaM 3mob m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
name: 3-methyl-2-oxobutanoate
boundary condition: false
type: Species
is: CHEBI:11851
initial concentration: 1.0
constant: false
is: HMDB00019

metaR r0179
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
product: MODEL1310110029#
reversible: true

metaM HC01408 m
is: SBO:0000247
is: CHEBI:27648
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 3-Oxohexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110029#_af213d41_d598_4aab_9e5d_2ec53a53aa62
is: SBO:0000297
constant: false
is encoded by: hsa:4831
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
has part: P15531
has part: P22392
name: NME1:NME2
initial concentration: NaN
has only substance units: false
type: Species

metaR RTOTAL3t
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
name: RTOTAL3 transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
fast: false
reversible: true

metaM HC00250 e
type: Species
has only substance units: false
is: CHEBI:29919
is: SBO:0000247
boundary condition: false
name: hydrosulfide
constant: false
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_98a2bf05_0935_476d_a8f8_1055c5cb1aa9
is encoded by: hsa:1036
name: CDO1
is: Q16878
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR FRUt4
fast: false
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
name: D-fructose transport via sodium cotransport
modifier: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
type: Reaction

metaM cdp m
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01546
type: Species
is: CHEBI:58069
has only substance units: false
constant: false
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_37af4a8c_811b_4f3f_b198_562b31fea351
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: INPP5D
is encoded by: hsa:3635
boundary condition: true
constant: false
is: Q92835

metaR r0731
fast: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reversible: false

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
product: MODEL1310110029#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.5.1.21

metaM HC02203 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27820
is: SBO:0000247
name: prostaglandin-a2
initial concentration: 1.0
type: Species
initial amount: NaN

metaM his L m
type: Species
name: L-histidine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15971
is: HMDB00177
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false

metaR r0627
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
reversible: true
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
is described by: ECO:0000000
fast: false

metaM gdp m
is: CHEBI:58189
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: C00035
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
name: GDP
initial amount: NaN
boundary condition: false

metaR GLYtm
type: Reaction
reversible: true
name: glycine passive transport to mitochondria
product: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110029#_2b2075b8_0a9b_4eda_b6eb_861753f4eea6
constant: false
initial amount: NaN
name: NDUFA13
is: Q9P0J0
is encoded by: hsa:51079
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM 3hibutcoa m
constant: false
is: CHEBI:28259
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species

metaR r1106
fast: false
type: Reaction
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_7795e43f_d1ff_4d3d_a945_fd395785cc64
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR FRDPtc
reversible: true
product: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
fast: false
is: SBO:0000185

metaM retn e
has only substance units: false
is: HMDB01852
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:35291
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
is: SBO:0000247

metaM asp L c
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
boundary condition: false
has only substance units: false
is: HMDB00191
type: Species
is: CHEBI:29991
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r0732
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110029#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000

metaM ru5p D r
is: HMDB00618
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58121
is: SBO:0000247
type: Species
name: D-ribulose 5-phosphate(2-)
boundary condition: false

metaM gly x
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00123
type: Species
is: CHEBI:15428
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine

metaM ser L e
boundary condition: false
type: Species
initial amount: NaN
name: L-serine
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
has only substance units: false
initial concentration: 1.0
is: HMDB00187

metaR r0022
product: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
reactant: MODEL1310110029#
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_f6fe1cbf_65fb_48d6_8e9e_24554d3e3972
is: SBO:0000252
has only substance units: false
name: NDUFA5
is: Q16718
is encoded by: hsa:4698
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_59ec28ae_8ce9_4c0a_ba19_83ca6a97c2bb
constant: false
initial concentration: NaN
is encoded by: hsa:1431
is: SBO:0000252
boundary condition: true
name: CS
type: Species
initial amount: NaN
has only substance units: false

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: L-aspartate(1-)
boundary condition: false
is: CHEBI:29991
initial amount: NaN

metaM gdp n
is: HMDB01201
constant: false
boundary condition: false
name: GDP(3-)
is: CHEBI:58189
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_97ec1333_1506_4abd_8441_a02ccd3083d2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51
type: Species
constant: false
name: ACOX1
initial amount: NaN
is: B4DK61

metaM HC00250 c
type: Species
is: CHEBI:29919
boundary condition: false
name: hydrosulfide
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r0733
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110029#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110029#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110029#_ec4263b2_d057_42f7_bcdc_17b6534fc30e
constant: false
has only substance units: false
is: O95169
is encoded by: hsa:4714
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFB8

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_41173128_0b71_44a1_9975_2e461f544a64
initial amount: NaN
is: SBO:0000252
name: OCRL
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4952
type: Species
constant: false

metaR r0021
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is: SBO:0000176
kinetic law: MODEL1310110029#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110029#
modifier: MODEL1310110029#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaR DCK2n
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction
is described by: ECO:0000269
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
kinetic law: MODEL1310110029#
reversible: true

metaM coa x
name: Coenzyme A
boundary condition: false
is: CHEBI:57287
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
type: Species
initial amount: NaN
is: C00010
constant: false
is: SBO:0000247
has only substance units: false

metaM glyclt c
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
is: HMDB00115
type: Species
initial amount: NaN
name: glycolate
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:29805

metaR r0629
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
type: Reaction
reactant: MODEL1310110029#
is: SBO:0000176
modifier: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
fast: false

metaM dopa e
has only substance units: false
is: HMDB00073
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: CHEBI:59905
name: dopaminium(1+)
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_858f4127_f85c_4d6d_bead_91600fa399dc
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:873
name: CBR1
is: P16152

metaM odecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: CHEBI:3793
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB01322

metaM CE2424 m
type: Species
initial concentration: 1.0
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN
is: HMDB11123
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424

http://identifiers.org/biomodels.db/MODEL1310110029#_45923dcf_e817_433e_aacf_2554b9f401f2
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI761708
name: _AI761708_1_m
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR GLYCt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
name: glycerol transport via channel
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110029#_4eb5e1bd_f9df_4cd9_a3c9_6b393882d174
has only substance units: false
name: SLC25A19
boundary condition: true
constant: false
is: Q9HC21
is: SBO:0000252
is encoded by: hsa:60386
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_85e5776c_9cd1_454b_a2d2_e05b2395c543
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110029#_34bc6eb2_56bb_4709_b322_6de7e92e46fa
is encoded by: hsa:219
boundary condition: true
is: P30837
name: ALDH1B1
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false

metaM dgchol c
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
is: SBO:0000247
is: HMDB00637
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:36252
name: glycochenodeoxycholate
constant: false

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: CHEBI:15991
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: Ferricytochrome c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_03fed411_d867_4f24_b11d_5a0e3bb01486
name: BDH1
is encoded by: hsa:622
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r0596
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
fast: false
is: SBO:0000176
modifier: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#

metaR r1254
fast: false
type: Reaction
name: EC:6.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
reactant: MODEL1310110029#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110029#_9d3ce112_8cbf_4b36_8e27_0a91100025da
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: Q7GXY8
type: Species
initial concentration: NaN
name: COX1
is encoded by: hsa:4512

metaR r1109
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
kinetic law: MODEL1310110029#
fast: false
reversible: true
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
is described by: ECO:0000000
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction

metaM acac c
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:13705
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00060

metaM HC02202 c
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57398
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

http://identifiers.org/biomodels.db/MODEL1310110029#_a5981383_a28a_4e6d_91b5_1540e552bde7
has only substance units: false
is encoded by: hsa:1120
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: CHKB
is: A0PJM6
constant: false

metaM prostgd2 e
is: CHEBI:57406
name: prostaglandin D2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
boundary condition: false
constant: false
is: HMDB01403
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dcdp m
has only substance units: false
initial concentration: 1.0
name: dCDP(3-)
type: Species
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:58593
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_4a8e1db7_8fef_4d27_8bc8_4a5d34d79fd0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA576959
initial concentration: NaN
boundary condition: true
name: _AA576959_1_c
has only substance units: false
type: Species
constant: false

metaR DATPtn
type: Reaction
fast: false
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
name: dATP diffusion in nucleus
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true

metaR TCHOLAtx
is: SBO:0000185
reactant: MODEL1310110029#
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
type: Reaction
fast: false

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
fast: false
name: Prostaglandin I2 transport
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000269
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_96fdbbf2_5fe3_448c_92a0_97907b542e06
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: SLC34A2
boundary condition: true
is: SBO:0000252
is: O95436
initial amount: NaN
is encoded by: hsa:10568

http://identifiers.org/biomodels.db/MODEL1310110029#_a88fef5e_5c4e_48e2_b15f_42d24614c15c
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: PYCR1
is: SBO:0000252
is: A6NFM2
is encoded by: hsa:5831

http://identifiers.org/biomodels.db/MODEL1310110029#_109dfd7e_06e1_4c76_815f_223c3bce6b61
boundary condition: true
is: P48728
has only substance units: false
type: Species
is encoded by: hsa:275
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AMT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_162f839d_6b60_4ae0_92bf_974b75ff0b6c
constant: false
boundary condition: true
is encoded by: hsa:7084
initial concentration: NaN
name: TK2
is: O00142
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_09adbc90_749e_40bc_8526_7c24ea60d281
is: SBO:0000252
name: DGKD
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8527
boundary condition: true
constant: false
type: Species

metaR 34DHXMANDACOX NADP
reversible: true
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
modifier: MODEL1310110029#
is described by: ECO:0000269
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_ed6602e4_3983_406a_a03d_5354b33a369f
type: Species
has only substance units: false
is: H7C5B8
constant: false
is encoded by: hsa:4708
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NDUFB2

metaR ICDHyrm
name: Isocitrate dehydrogenase (NADP+)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is: SBO:0000176
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110029#
product: MODEL1310110029#
reversible: true

metaM dcdp n
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58593
constant: false
is: HMDB01245
has only substance units: false
boundary condition: false
name: dCDP(3-)

metaM cmpacna n
type: Species
boundary condition: false
constant: false
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: SBO:0000247
is: HMDB01176
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_29ffe705_0faf_4f4e_9c7d_749a1917361b
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI824319
initial concentration: NaN
name: _AI824319_1_r
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_cca31d1d_6ff7_44f9_b8b4_d8464f92f7e3
initial concentration: NaN
initial amount: NaN
constant: false
name: HSD3B1
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P14060
type: Species
is encoded by: hsa:3283

metaM dcholcoa c
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
boundary condition: false
type: Species
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: HMDB06292
is: CHEBI:28701
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a146da99_fc29_48fd_9d73_94d195f5f9d4
is: P00491
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:4860
is: SBO:0000252
name: PNP
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM dcacoa m
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
initial amount: NaN
is: HMDB06404
type: Species
is: C05274
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:61430
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a398472a_efc7_48ba_823b_c18419ce6285
is encoded by: hsa:1376
boundary condition: true
constant: false
is: P23786
is: SBO:0000252
name: CPT2
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR GBA
fast: false
product: MODEL1310110029#
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.2.1.45
name: Glucosylceramidase
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
reversible: false
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ

metaM thcholoylcoa x
constant: false
type: Species
is: HMDB12456
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27403
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247

metaM 4hoxpacd c
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: (4-hydroxyphenyl)acetaldehyde
is: HMDB03767
boundary condition: false
is: CHEBI:15621
initial concentration: 1.0
constant: false

metaR MALSO4tm
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
name: Malate:sulfate antiport, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d8edc89e_99ba_4a12_a9b3_b578452eb162
name: SLCO4A1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:28231
is: Q96BD0
initial amount: NaN
constant: false

metaM his L e
has only substance units: false
boundary condition: false
is: CHEBI:15971
is: HMDB00177
is: SBO:0000247
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r0170
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
product: MODEL1310110029#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_bb1eb728_db67_4c4b_9103_f1b4b92a7d79
boundary condition: true
has only substance units: false
is: P33897
constant: false
initial amount: NaN
is encoded by: hsa:215
type: Species
name: ABCD1
is: SBO:0000252
initial concentration: NaN

metaM malthx e
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: C01936
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose

metaR DTDPtn
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
name: dTDP nuclear transport
type: Reaction
reversible: true
is described by: ECO:0000000

metaR r0451
is: SBO:0000176
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110029#
type: Reaction
reversible: false
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#

metaM HC01602 c
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
is: CHEBI:57454
boundary condition: false
constant: false
name: 10-Formyltetrahydrofolate
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaM cdp e
is: SBO:0000247
initial concentration: 1.0
is: HMDB01546
initial amount: NaN
type: Species
is: CHEBI:58069
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
boundary condition: false

metaM HC02187 e
constant: false
name: reverse-triiodthyronine
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
is: SBO:0000247

metaR r1812
reversible: false
fast: false
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
product: MODEL1310110029#

metaR r1965
reversible: false
modifier: MODEL1310110029#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#

metaM gal e
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:0
is: C00124

http://identifiers.org/biomodels.db/MODEL1310110029#_fbe3bb7b_8f4c_4b24_b43b_05e862b8dbda
type: Species
has only substance units: false
name: PCBD2
is: SBO:0000252
is: Q9H0N5
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:84105
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_fc5c0084_4eec_4e0d_abce_4921769a6551
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: SLC12A6
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9UHW9
is encoded by: hsa:9990

metaR RADH
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal dehydrogenase
product: MODEL1310110029#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
reversible: true

metaM mag hs c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
has only substance units: false
constant: false
is: HMDB12130
is: CHEBI:16987
initial amount: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_5b4d65a3_647f_442f_95f3_85d601c5e2d8
is encoded by: hsa:84649
is: Q96PD7
name: DGAT2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true

metaM pail34p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57658

metaR r2013
is: SBO:0000185
modifier: MODEL1310110029#
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM HC01410 m
has only substance units: false
name: (2E)-Hexenoyl-CoA
initial amount: NaN
is: CHEBI:28706
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
constant: false

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
product: MODEL1310110029#
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-

metaR r0509
is: SBO:0000176
reversible: false
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
kinetic law: MODEL1310110029#

metaM r5p c
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: C00117
initial amount: NaN
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:18189

metaR r1605
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110029#

metaM ascb L e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
is: HMDB00044
boundary condition: false
name: L-ascorbate
type: Species
is: CHEBI:38290

metaR URIt
name: uridine facilated transport in cytosol
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_635e38bb_6993_465c_8cc7_05fdf7ca7f44
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: _NOS2A_1_e
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:NOS2A

http://identifiers.org/biomodels.db/MODEL1310110029#_ed44fca8_25ce_44f4_80de_059a199b4f91
type: Species
is: Q9NVS9
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:55163
name: PNPO
has only substance units: false

metaR TRIOK
fast: false
is: SBO:0000176
reversible: false
name: triokinase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD

metaM pglyc hs c
initial amount: NaN
is: CHEBI:15589
has only substance units: false
notes: FORMULA: CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: pglyc_hs[c]
is: HMDB00156

metaM pglyc hs e
initial amount: NaN
constant: false
boundary condition: false
name: phosphatidylglycerol(1-)
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60523

http://identifiers.org/biomodels.db/MODEL1310110029#_0a6151ff_2bfd_44c6_910b_102a35f5f909
is: SBO:0000252
is: Q16719
is encoded by: hsa:8942
initial amount: NaN
name: KYNU
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM CE1944 c
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
is: SBO:0000247
name: 1-pyrrolinium
has only substance units: false
initial amount: NaN
is: CHEBI:36781
type: Species

metaR CYTK3n
reactant: MODEL1310110029#
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110029#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110029#
reversible: true
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110029#_4832df0e_4a20_4a2f_8da3_568ebb6498a7
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: FLAD1
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:80308

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1964
kinetic law: MODEL1310110029#
fast: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#
product: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_9c595548_6350_4594_ac3f_9260fb23415c
constant: false
type: Species
name: SGPP2
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:130367
is: SBO:0000252
is: Q8IWX5

metaR r2014
type: Reaction
is: SBO:0000185
modifier: MODEL1310110029#
reversible: false
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR RE0830N
product: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
reactant: MODEL1310110029#
is: SBO:0000176
kinetic law: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
name: RE0830

metaM dadp c
initial concentration: 1.0
is: C00206
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
is: CHEBI:57667
type: Species
name: dADP
is: HMDB01508
initial amount: NaN

metaM 34dhpha c
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: CHEBI:17612
name: (3,4-dihydroxyphenyl)acetate
initial concentration: 1.0
is: HMDB01336

metaR r1606
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110029#
reversible: true

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57917
is: HMDB01232
name: 4-nitrophenolate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_e59e43d6_6e1b_4e9e_a86f_96b503d3eab0
name: AADAT
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51166
is: Q4W5N8

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaM ca2 c
name: calcium(2+)
initial concentration: 1.0
is: CHEBI:29108
is: HMDB00464
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaR RE3050R
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110029#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
name: RE3050

metaM HC02187 c
initial concentration: 1.0
name: reverse-triiodthyronine
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaM cdp c
has only substance units: false
initial concentration: 1.0
name: CDP
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
is: HMDB01546
constant: false
initial amount: NaN
is: C00112
is: CHEBI:58069
is: SBO:0000247

metaR r1764
fast: false
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110029#

metaR ALADGLYexR
is: SBO:0000185
name: D-alanine/glycine reversible exchange
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
is described by: ECO:0000304
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#

metaR RE2079R
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
reversible: true
name: RE2079
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110029#
type: Reaction
fast: false

metaM mag hs e
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: HMDB00673
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: monoacylglycerol 2
boundary condition: false
is: SBO:0000247
is: CHEBI:30245
type: Species
constant: false

metaR RE3326M
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110029#
is described by: ECO:0000000
name: RE3326
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110029#
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true

metaM gal c
is: C00124
name: D-Galactose
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
modifier: MODEL1310110029#
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is: SBO:0000176
reactant: MODEL1310110029#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.18

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR r1607
kinetic law: MODEL1310110029#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ascb L c
is: HMDB00044
is: CHEBI:38290
constant: false
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
name: L-ascorbate
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaR NDP8ex
kinetic law: MODEL1310110029#
name: nucleoside-diphosphatase (UTP), extracellular
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
product: MODEL1310110029#
reactant: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
reversible: false
fast: false

metaR FADH2tx
name: FADH2 transporter, peroxisomal
reversible: true
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110029#_55f8d9ac_f6ac_4af2_b63b_7613c9f4390a
has only substance units: false
boundary condition: true
initial amount: NaN
is: A8K0S7
name: SLC37A4
is encoded by: hsa:2542
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_81978554_07f2_4526_962c_d27becbfdb8c
initial amount: NaN
name: PRDX2
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7001
has only substance units: false
boundary condition: true
type: Species

metaR THYOXt2
product: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction
name: T4 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_7c132b60_8de6_4b19_b54f_7b53a1eb1056
initial concentration: NaN
is: SBO:0000252
is: O14732
type: Species
constant: false
name: IMPA2
initial amount: NaN
is encoded by: hsa:3613
boundary condition: true
has only substance units: false

metaR TRDR
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110029#

metaR NADS2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
name: NAD synthase (glutamine-hydrolysing)
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
fast: false

metaM crn r
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
name: (R)-carnitine
is: SBO:0000247
has only substance units: false
is: CHEBI:16347
is: HMDB00062
initial concentration: 1.0

metaR RE1532M
reversible: true
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1532
type: Reaction
product: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is: SBO:0000176
reactant: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_d524bd7b_1d2e_4c24_b1e3_4c9f375528d9
is: Q308M7
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ENPP3
boundary condition: true
is encoded by: hsa:5169

http://identifiers.org/biomodels.db/MODEL1310110029#_a9969c84_b4ab_4f90_9bc1_3801c91cf81e
is: SBO:0000252
is: P35557
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2645
name: GCK

metaR CLOHtex2
reversible: false
modifier: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
type: Reaction
fast: false
reactant: MODEL1310110029#
name: chloride transport via hydroxide countertransport (2:1)

metaR KYNATESYN
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000176
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#

metaR ADKd
modifier: MODEL1310110029#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110029#
reactant: MODEL1310110029#
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110029#

metaR RE1518M
reversible: true
product: MODEL1310110029#
type: Reaction
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR DGK1
is: SBO:0000176
type: Reaction
name: deoxyguanylate kinase (dGMP:ATP)
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
kinetic law: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_424ae565_d6ea_4a0d_9b40_08230dad9323
has only substance units: false
constant: false
boundary condition: true
name: _AI373818_1_m
initial concentration: NaN
is encoded by: hsa:AI373818
initial amount: NaN
is: SBO:0000252
type: Species

metaM dopa c
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
is: HMDB00073
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:59905

metaR ABTD
product: MODEL1310110029#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
name: L-arabinitol 4-dehydrogenase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD

metaM 34dhpac c
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB03791
initial concentration: 1.0
is: CHEBI:27978
name: 3,4-Dihydroxyphenylacetaldehyde
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_65328e9c_7524_4828_bec8_7d6a11659718
is encoded by: hsa:125
boundary condition: true
initial amount: NaN
is: P00325
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: ADH1B
is: SBO:0000252

metaM ca2 e
is: SBO:0000247
is: HMDB00464
initial concentration: 1.0
has only substance units: false
is: CHEBI:29108
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaM 34hpp c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f9f25017_ef2c_4bb0_98dd_5d088c99e3c4
is encoded by: hsa:10588
is: SBO:0000252
name: MTHFS
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: P49914

metaR r1608
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
type: Reaction
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110029#
reversible: true

metaR GLYOp
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
product: MODEL1310110029#
reversible: false
is: SBO:0000176
reactant: MODEL1310110029#
fast: false
name: glycine oxidase, perixosomal
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM 3mop c
name: 3-methyl-2-oxopentanoate
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
type: Species
is: HMDB00491
is: CHEBI:28654
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_840a34ff_e41b_4a03_a765_13eb7e59a42e
is encoded by: hsa:51179
has only substance units: false
name: HAO2
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9NYQ3
initial concentration: NaN
boundary condition: true
type: Species

metaR CITt4 2
product: MODEL1310110029#
is: SBO:0000185
fast: false
reactant: MODEL1310110029#
name: citrate transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reversible: true
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000269

metaM HC00229 e
name: Isomaltose
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:28189

metaR r2312
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_75a15cbd_5822_4a25_a339_4038892919cc
has only substance units: false
is encoded by: hsa:AL048840
boundary condition: true
name: _AL048840_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_51692dbd_832d_4a12_b84a_b9d0d4636ab6
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ESCO2
constant: false
initial amount: NaN
is encoded by: hsa:157570
boundary condition: true
is: Q56NI9

http://identifiers.org/biomodels.db/MODEL1310110029#_ce4e1f40_c417_4ce2_b1b3_82c105191a4a
initial amount: NaN
is: P00338
type: Species
is encoded by: hsa:3939
has only substance units: false
name: LDHA
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR CMPACNAtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110029#
type: Reaction
name: CMP-Sia nuclear export
is described by: ECO:0000000
reversible: false
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#

metaM crm hs e
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:52639
boundary condition: false
initial amount: NaN
constant: false
name: N-acylsphingosine

metaM Lfmkynr c
is: SBO:0000247
is: HMDB01200
boundary condition: false
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
name: N-formyl-L-kynurenine
constant: false
has only substance units: false
is: CHEBI:30249
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110029#_40866e61_656a_45c3_abd5_8177fe1bb951
name: MIA3
is encoded by: hsa:375056
initial amount: NaN
boundary condition: true
is: Q5JRA6
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110029#_d6ad0ef0_f47e_4d0a_bcd7_62dbc07551c6
initial concentration: NaN
name: NDUFA7
is: SBO:0000252
is encoded by: hsa:4701
initial amount: NaN
constant: false
is: Q6FG42
has only substance units: false
type: Species
boundary condition: true

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_f814a367_9ff2_4393_8964_337d554f29ac
has only substance units: false
name: INPP5J
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:27124

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM lcts e
type: Species
name: Lactose
is: CHEBI:17716
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
is: HMDB00186
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00243
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110029#_4e2f9a53_37ad_4816_b4e5_f2797174415d
is encoded by: hsa:4537
boundary condition: true
constant: false
initial concentration: NaN
is: P03897
is: SBO:0000252
initial amount: NaN
type: Species
name: ND3
has only substance units: false

metaR RE0691C
type: Reaction
name: RE0691
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a70925dd_1c6d_47a6_bfec_613e5c1f0e4d
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: O75489
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFS3
is encoded by: hsa:4722

metaR r1609
kinetic law: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110029#
type: Reaction
is: SBO:0000185
reversible: true

metaR r0504
modifier: MODEL1310110029#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110029#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_0e99df5f_f1da_42a5_ba8f_aaf555982274
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: HPD
has only substance units: false
boundary condition: true
is encoded by: hsa:3242
is: B3KQ63
constant: false

metaM pail hs c
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
initial concentration: 1.0
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN

metaR r2313
fast: false
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
product: MODEL1310110029#

metaR r0456
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110029#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
modifier: MODEL1310110029#
is: SBO:0000176
is described by: ECO:0000000

metaR r1960
fast: false
reactant: MODEL1310110029#
reversible: false
product: MODEL1310110029#
modifier: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110029#_bf395ddd_880c_4f41_b9cb_608bef990cc5
is: SBO:0000252
is encoded by: hsa:126129
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q8TCG5
name: CPT1C
initial amount: NaN

metaR TXA2te
kinetic law: MODEL1310110029#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
name: thromboxane A2 transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110029#
product: MODEL1310110029#

metaR RE1807C
reactant: MODEL1310110029#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
product: MODEL1310110029#

metaM crm hs c
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:52639
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
name: N-acylsphingosine
initial amount: NaN

metaR PEt
reversible: true
reactant: MODEL1310110029#
fast: false
is described by: ECO:0000000
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
name: phosphatidylethanolamine transport
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_a92631cc_4fa5_41d0_b8b5_43de55f7ba14
has only substance units: false
is: P00558
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5230
boundary condition: true
name: PGK1
constant: false

metaM bilirub r
initial concentration: 1.0
is: HMDB00054
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
is: CHEBI:57977
name: bilirubin(2-)
boundary condition: false
has only substance units: false
type: Species
constant: false

metaM na1 e
has only substance units: false
boundary condition: false
is: CHEBI:4541
initial concentration: 1.0
is: C01330
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: Sodium

metaM 34hpp e
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: CHEBI:36242

http://identifiers.org/biomodels.db/MODEL1310110029#_3b9f403c_4232_4957_bade_ef871b8a3440
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR CITt4 4
fast: false
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: citrate transport via sodium symport
reversible: true
is described by: ECO:0000006
modifier: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_c58ac0f6_8068_4d69_9536_396d01c5b838
is: SBO:0000252
is: P08842
boundary condition: true
is encoded by: hsa:412
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: STS

metaM 5thf e
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:48999
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: HMDB00020
type: Species
initial amount: NaN
initial concentration: 1.0
name: pentaglutamyl folate (THF)

metaR r2393
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction

metaM crm hs g
name: N-acylsphingosine
type: Species
is: CHEBI:52639
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_ff3e808e_c909_47f6_b112_420963ad5d3e
has only substance units: false
boundary condition: true
initial amount: NaN
name: SUOX
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6821
is: P51687
constant: false

metaM h2o2 e
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16240
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: HMDB03125
type: Species
is: SBO:0000247
has only substance units: false

metaR r2310
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110029#
reversible: true
type: Reaction
product: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR BILGLCURtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
name: glucuronidated compound transport
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false
reversible: true

metaR RE3245C
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
is described by: ECO:0000000
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is: SBO:0000176
reactant: MODEL1310110029#
fast: false
type: Reaction

metaM 3aib D m
has only substance units: false
is: SBO:0000247
name: D-3-Amino-isobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB02299
constant: false
boundary condition: false
is: C03265

metaR DUMPtn
name: dUMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110029#
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
reversible: true

metaR HEX1
reactant: MODEL1310110029#
fast: false
name: hexokinase (D-glucose:ATP)
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: false
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2

http://identifiers.org/biomodels.db/MODEL1310110029#_ffba44fd_23e4_420c_9a6c_497ba002302a
name: ALDOC
is: P09972
initial concentration: NaN
has only substance units: false
is encoded by: hsa:230
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_ba086738_cf7f_4aa8_b43f_549d40a51a45
is: SBO:0000252
has only substance units: false
name: PC
is: P11498
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5091

metaR CHLtm
fast: false
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
name: choline transport via diffusion (cytosol to mitochondria)
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
is described by: ECO:0000000
product: MODEL1310110029#

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110029#
fast: false
kinetic law: MODEL1310110029#
is described by: ECO:0000000

metaR BETALDHxm
name: betaine-aldehyde dehydrogenase, mitochondrial
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reversible: false

metaM bilglcur r
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57767
initial concentration: 1.0
type: Species

metaM pacald c
initial amount: NaN
is: HMDB06236
has only substance units: false
is: SBO:0000247
boundary condition: false
name: phenylacetaldehyde
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
constant: false
initial concentration: 1.0
is: CHEBI:16424
type: Species

metaM C05957 r
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
is: HMDB02710
initial amount: NaN
has only substance units: false
is: CHEBI:27485
is: SBO:0000247
boundary condition: false
name: Prostaglandin J2

metaM crn m
is: C00318
type: Species
constant: false
is: HMDB00062
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
name: L-Carnitine
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM na1 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
is: C01330
is: HMDB00588
name: Sodium
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM HC01434 x
is: CHEBI:58931
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaM cholate e
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
is: SBO:0000247
type: Species
name: Cholate
is: HMDB00619
is: CHEBI:29747
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_7b05d08c_db1a_4e54_a35c_87f5426ed801
name: SLC3A2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6520
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: P08195

http://identifiers.org/biomodels.db/MODEL1310110029#_101934ae_0571_4377_943e_b27b8c5c2839
is: SBO:0000252
name: ALDH2
is encoded by: hsa:217
is: P05091
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_a23ba9dd_6604_4f2c_b226_73cf1b684544
is: SBO:0000252
type: Species
boundary condition: true
name: _U37519_1_c
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:U37519
initial concentration: NaN

metaM mi13p c
is: CHEBI:18225
initial concentration: 1.0
is: SBO:0000247
name: 1D-myo-Inositol 1,3-bisphosphate
is: HMDB06234
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
has only substance units: false
boundary condition: false

metaR UDPGLCter
reversible: true
reactant: MODEL1310110029#
type: Reaction
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185

metaM ade e
name: adenine
initial concentration: 1.0
constant: false
is: CHEBI:16708
is: SBO:0000247
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r2395
product: MODEL1310110029#
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#

metaR r2316
fast: false
kinetic law: MODEL1310110029#
type: Reaction
is: SBO:0000185
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110029#
is described by: ECO:0000000

metaM dcdp c
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
boundary condition: false
is: C00705
has only substance units: false
name: dCDP
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58593
is: HMDB01245
constant: false

metaR TCHOLAte
reversible: true
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
product: MODEL1310110029#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
name: bile acid intracellular transport

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
name: Glycerol 3-phosphate
has only substance units: false
is: HMDB00126
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57597
type: Species

metaR r0236
type: Reaction
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_f66ceab4_7bbf_4aca_b946_1d093ba55cca
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: G3V0F6
has only substance units: false
name: DGKZ
is encoded by: hsa:8525
is: SBO:0000252

metaR HEX4
name: hexokinase (D-mannose:ATP)
product: MODEL1310110029#
reversible: false
fast: false
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is described by: ECO:0000304
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_022f711e_793f_4e73_a22a_a0faed73dfa1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC38A4
is encoded by: hsa:55089
initial amount: NaN
constant: false
boundary condition: true
is: Q969I6
type: Species

metaR r1547
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110029#
reversible: true

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57767

http://identifiers.org/biomodels.db/MODEL1310110029#_c1e76733_8a1f_40a9_9d19_739cb66eb415
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50484
type: Species
is: SBO:0000252
is: Q7LG56
name: RRM2B
constant: false

metaR FOLt2le
is: SBO:0000185
reactant: MODEL1310110029#
is described by: ECO:0000134
kinetic law: MODEL1310110029#
reversible: true
fast: false
product: MODEL1310110029#
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR PItg
is described by: ECO:0000000
name: phosphate transport, Golgi apparatus
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110029#
is: SBO:0000185
product: MODEL1310110029#

metaM 2mop c
is: CHEBI:57700
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01172
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
constant: false
name: 2-methyl-3-oxopropanoate
boundary condition: false

metaR MMSAD3m
is: SBO:0000176
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110029#
fast: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
product: MODEL1310110029#
type: Reaction
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD

metaM c4crn e
is: HMDB02013
name: butyryl carnitine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
type: Species
has only substance units: false
is: C02862
constant: false

metaM CE2418 m
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: HMDB11123
is: CHEBI:28387
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110029#_38f7a752_ffc0_4c56_ada4_a0b36f699724
is: SBO:0000252
initial concentration: NaN
name: RDH16
constant: false
type: Species
is: O75452
is encoded by: hsa:8608
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r2394
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110029#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM 6pgl r
constant: false
is: CHEBI:57955
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_b646d92d_31e3_480d_a0bc_ee4e53989f46
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55349
name: CHDH
type: Species
boundary condition: true
is: Q8NE62

http://identifiers.org/biomodels.db/MODEL1310110029#_11044ad8_beec_407d_8bec_4bc422deeea1
initial amount: NaN
name: SLC16A7
type: Species
is encoded by: hsa:9194
constant: false
is: SBO:0000252
is: Q8NEM3
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r2317
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1546
product: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110029#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dadp m
constant: false
name: dADP(3-)
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01508
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_9efd708d_52f8_4502_9afe_adac7db5ab3a
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ACP6
type: Species
is: Q9NPH0
initial concentration: NaN
is encoded by: hsa:51205

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_994ce0cd_1dc7_4cbe_aade_cf0f7323217a
initial amount: NaN
is encoded by: hsa:2954
is: SBO:0000252
constant: false
boundary condition: true
name: GSTZ1
initial concentration: NaN
type: Species
has only substance units: false
is: A6NED0

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110029#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110029#
fast: false
product: MODEL1310110029#

metaR NDPK6m
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110029#
is: SBO:0000176
fast: false
reversible: true

metaR DGCHOLte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
kinetic law: MODEL1310110029#
product: MODEL1310110029#
is: SBO:0000185
reactant: MODEL1310110029#
type: Reaction
name: bile acid intracellular transport
is described by: ECO:0000000

metaM dudp m
is: SBO:0000247
is: HMDB01000
initial concentration: 1.0
has only substance units: false
name: dUDP(3-)
initial amount: NaN
type: Species
is: CHEBI:60471
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR SUCOASm
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Succinate--CoA ligase (ADP-forming)
is: SBO:0000176
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
type: Reaction
product: MODEL1310110029#
modifier: MODEL1310110029#
fast: false

metaR r2314
product: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110029#

metaR GK1
is: SBO:0000176
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction

metaR HACD1m
is: SBO:0000176
reactant: MODEL1310110029#
modifier: MODEL1310110029#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reversible: true
product: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM dadp n
has only substance units: false
name: dADP(3-)
type: Species
initial amount: NaN
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57667

metaR CYSO
is: SBO:0000176
name: cysteine oxidase
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110029#
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reactant: MODEL1310110029#

metaR NDPK6n
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000304
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
reversible: true
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR 2HBO
type: Reaction
fast: false
reactant: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reversible: true
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_c8bb657b_3e3b_401a_ae4b_4463cb7ce6ff
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1345
is: P09669
type: Species
name: COX6C

metaM dudp n
boundary condition: false
has only substance units: false
name: dUDP(3-)
initial amount: NaN
type: Species
constant: false
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60471

metaR r2396
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
product: MODEL1310110029#
type: Reaction

metaR RE1526M
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE1526
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110029#

metaR r2315
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110029#
is described by: ECO:0000000
fast: false

metaR r0502
reversible: true
fast: false
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.113
product: MODEL1310110029#
type: Reaction
kinetic law: MODEL1310110029#

metaR r1600
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
product: MODEL1310110029#

metaM kynate c
constant: false
is: HMDB00715
has only substance units: false
type: Species
name: kynurenate
initial concentration: 1.0
boundary condition: false
is: CHEBI:58454
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247

metaR r0233
product: MODEL1310110029#
reversible: false
is: SBO:0000176
reactant: MODEL1310110029#
is described by: ECO:0000000
kinetic law: MODEL1310110029#
name: UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase Galactose metabolism / Nucleotide sugars metabolism EC:2.7.7.12
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.22
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:10993714 NOTES:
fast: false
modifier: MODEL1310110029#

http://identifiers.org/biomodels.db/MODEL1310110029#_7f4b9110_90c7_4971_b4d7_f013c6cf37d9
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:2936
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: GSR
is: P00390
constant: false

metaM trdox c
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Oxidized thioredoxin
initial concentration: 1.0
type: Species
boundary condition: false
is: C00343
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110029#
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_2a1c71ae_6fdd_4023_9a87_5705177c1c10
is encoded by: hsa:6647
name: SOD1
is: SBO:0000252
is: P00441
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR L LACDcm
reversible: false
product: MODEL1310110029#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110029#
reactant: MODEL1310110029#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_4c0e0125_5a10_4629_8335_854db0c36fa8
type: Species
constant: false
is encoded by: hsa:43
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ACHE
boundary condition: true
is: SBO:0000252

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01123
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16567
name: anthranilate

metaM hLkynr c
is: CHEBI:17380
type: Species
is: HMDB11631
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxy-L-kynurenine
constant: false
initial amount: NaN
has only substance units: false

metaR r1969
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_b5eeafbd_1d86_4f67_a8b4_4271457a0c14
is: P51178
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PLCD1
is encoded by: hsa:5333
has only substance units: false
initial concentration: NaN
type: Species

metaR UMPK5n
name: UMP kinase (dATP),nuclear
modifier: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000176
fast: false
product: MODEL1310110029#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_5990915e_fc37_4fce_ba27_0a81d64ab6ad
is: P49189
name: ALDH9A1
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:223
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2399
kinetic law: MODEL1310110029#
reversible: false
reactant: MODEL1310110029#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110029#_49d97d3b_bed8_40af_af17_771c5975c8ec
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q96KJ9
name: COX4I2
constant: false
is encoded by: hsa:84701
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_64afed58_71f1_4f7e_b237_af082badbef3
is encoded by: hsa:3098
name: HK1
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P78542
initial amount: NaN

metaR DGAT
kinetic law: MODEL1310110029#
is: SBO:0000176
product: MODEL1310110029#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
modifier: MODEL1310110029#
name: diacylglycerol acyltransferase
reactant: MODEL1310110029#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110029#_725e8c39_d023_4ff7_bb34_6537e9e9d30a
constant: false
name: HADHA:HADHB
has part: E9KL44
is: SBO:0000297
boundary condition: true
has part: P55084
type: Species
is encoded by: hsa:3032
is encoded by: hsa:3030
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR 34HPPte
type: Reaction
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000185
fast: false
product: MODEL1310110029#
is described by: ECO:0000134
kinetic law: MODEL1310110029#
reversible: true
reactant: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_5003a9e6_0ce5_447e_8b5e_5585dd8d2f25
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: Q9NTF0
is encoded by: hsa:875
type: Species
name: CBS
has only substance units: false
initial concentration: NaN

metaR HEX7
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110029#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
product: MODEL1310110029#
fast: false
name: hexokinase (D-fructose:ATP)
is described by: ECO:0000304
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.7.1.1

metaM h2o2 n
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
name: hydrogen peroxide
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110029#_a570d1ad_32b8_4ae6_a2f6_1855931ca4ad
initial concentration: NaN
is encoded by: hsa:4594
name: MUT
is: P22033
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR PVD3
is: SBO:0000176
reactant: MODEL1310110029#
name: Previtamin D3 formation
product: MODEL1310110029#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
kinetic law: MODEL1310110029#
is described by: ECO:0000134
reversible: true

metaR r1602
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110029#
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110029#

metaM fol c
has only substance units: false
name: Folate
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1

metaR r1401
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.3.1.51
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110029#
product: MODEL1310110029#
reversible: false
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.35

metaM dcholcoa r
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: HMDB06292
is: CHEBI:28701
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110029#_86a1d2ca_3788_45ec_90fe_2db7f82b85b5
is encoded by: hsa:1103
is: Q6LEN6
name: CHAT
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110029#_9e2d303c_09d3_4bb3_a1e6_882b28d2447f
constant: false
name: LEFTY1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10637
type: Species
initial amount: NaN
is: O75610
has only substance units: false

metaR PItn
product: MODEL1310110029#
kinetic law: MODEL1310110029#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110029#
name: phosphate transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110029#_6e875ec0_9cfe_4d78_98e5_64b1704dd461
initial concentration: NaN
type: Species
initial amount: NaN
name: _AI684467_1_m
is encoded by: hsa:AI684467
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110029#_b76fc23b_4883_4063_8328_27c1d5f7263c
constant: false
name: ADH1B:ADH1C
is encoded by: hsa:126
boundary condition: true
has part: P00326
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000297

metaM pail hs n
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57880
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR DOLPMT4 Ler
product: MODEL1310110029#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110029#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110029#

metaM anth c
initial concentration: 1.0
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01123
has only substance units: false
boundary condition: false
constant: false
name: anthranilate
is: CHEBI:16567

metaR r0842
reversible: true
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110029#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
modifier: MODEL1310110029#
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:

metaR r1603
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110029#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110029#
reversible: true
is: SBO:0000185

metaM h2o2 m
is: SBO:0000247
is: C00027
name: Hydrogen peroxide
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: CHEBI:16240
has only substance units: false
initial amount: NaN
constant: false
is: HMDB03125

metaR r2318
fast: false
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110029#

metaR DUDPtn
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110029#
name: dUDP nuclear transport
is described by: ECO:0000000
kinetic law: MODEL1310110029#
product: MODEL1310110029#
fast: false

metaM his L c
constant: false
is: HMDB00177
is: SBO:0000247
is: CHEBI:15971
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
name: L-histidine
boundary condition: false

metaM gly m
is: HMDB00123
name: Glycine
constant: false
is: CHEBI:15428
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00037
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
reversible: true
fast: false
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
product: MODEL1310110029#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110029#
modifier: MODEL1310110029#

metaR BAMPPALDOX
is: SBO:0000176
product: MODEL1310110029#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110029#
type: Reaction
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
kinetic law: MODEL1310110029#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB

metaM pan4p m
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
type: Species
has only substance units: false
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r1400
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
kinetic law: MODEL1310110029#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110029#_04d955e6_5883_4eb0_bd64_726049ebda8a
initial concentration: NaN
name: CPT1B
has only substance units: false
type: Species
is: Q53FV7
boundary condition: true
is encoded by: hsa:1375
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110029#_17c65a76_c784_4ca5_9556_8bc74a8615d4
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: TUSC3
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:7991

metaM c4crn c
is: SBO:0000247
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: butyryl carnitine
is: C02862

metaR RE0830C
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110029#
product: MODEL1310110029#
type: Reaction
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000176
name: RE0830

metaM crn e
boundary condition: false
name: L-Carnitine
initial amount: NaN
constant: false
is: HMDB00062
type: Species
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: C00318
has only substance units: false
initial concentration: 1.0

metaM retinol 9 cis e
initial amount: NaN
boundary condition: false
is: CHEBI:17336
constant: false
is: HMDB06217
is: SBO:0000247
type: Species
name: 9-cis-retinol
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110029#_4b876381_950f_4827_b995_c576d87f79cf
name: SLC29A2
type: Species
is encoded by: hsa:3177
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q14542
initial amount: NaN

metaR r1604
is: SBO:0000185
kinetic law: MODEL1310110029#
is described by: ECO:0000000
reactant: MODEL1310110029#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110029#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r2319
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
reversible: true
product: MODEL1310110029#
is: SBO:0000185
kinetic law: MODEL1310110029#
reactant: MODEL1310110029#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0841
name: Free diffusion
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110029#
product: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.1.1.271
fast: false
reactant: MODEL1310110029#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110029#_5b3cdce6_a1d7_4982_9767_d865c50e0e8c
is: O00767
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: SCD
boundary condition: true
is encoded by: hsa:6319
initial concentration: NaN

metaR r1540
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
modifier: MODEL1310110029#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
kinetic law: MODEL1310110029#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
fast: false
product: MODEL1310110029#
reactant: MODEL1310110029#
is: SBO:0000185

metaR r0450
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reactant: MODEL1310110029#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
product: MODEL1310110029#
modifier: MODEL1310110029#
reversible: true
kinetic law: MODEL1310110029#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM fol e
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
name: Folate
is: SBO:0000247
is: HMDB00121
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaR CAATPS
product: MODEL1310110029#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is described by: ECO:0000269
reactant: MODEL1310110029#
kinetic law: MODEL1310110029#
is version of: http://identifiers.org/ec-code/3.6.3.8
is: SBO:0000185
modifier: MODEL1310110029#
fast: false
name: Ca ATPase

metaM 3mob c
initial amount: NaN
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:11851
initial concentration: 1.0
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston